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Overview

ID MAG01667
Name HFD2_bin.64
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Gemmatimonadota
Class Gemmatimonadetes
Order Gemmatimonadales
Family GWC2-71-9
Genus DASTHG01
Species
Assembly information
Completeness (%) 75.89
Contamination (%) 2.02
GC content (%) 70.0
N50 (bp) 5,028
Genome size (bp) 2,621,050

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2544

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1001489_0 efflux transmembrane transporter activity - - - 3.74e-201 662.0
HFD2_k127_1001489_1 TonB dependent receptor K16089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008315 413.0
HFD2_k127_1001489_2 tRNA wobble cytosine modification - - - 0.0000000000000000000000000000000000000000000000000000000008195 213.0
HFD2_k127_1001489_3 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000000000000002795 179.0
HFD2_k127_1001489_4 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000001386 128.0
HFD2_k127_1001489_5 sulfuric ester hydrolase activity - - - 0.000000000000001269 82.0
HFD2_k127_1003344_0 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 346.0
HFD2_k127_1003344_1 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000001334 220.0
HFD2_k127_1003344_2 Dihydrodipicolinate synthetase family - - - 0.000000000000000000000000000000000000000000000005685 179.0
HFD2_k127_1003344_3 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000001099 70.0
HFD2_k127_1009054_0 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 415.0
HFD2_k127_1009054_1 Conserved hypothetical protein (DUF2461) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004935 279.0
HFD2_k127_1009054_2 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000003244 99.0
HFD2_k127_1009054_3 Flavin-binding monooxygenase-like K07222 - - 0.00000000001712 65.0
HFD2_k127_1009819_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000789 378.0
HFD2_k127_1009819_1 - - - - 0.0000000000000003854 85.0
HFD2_k127_1009819_2 Predicted membrane protein (DUF2231) - - - 0.000000001682 70.0
HFD2_k127_1012842_0 TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01539 - 3.6.3.9 0.0 1042.0
HFD2_k127_1012842_1 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 3.426e-201 647.0
HFD2_k127_1012842_2 COG0840 Methyl-accepting chemotaxis protein - - - 0.0000000000000000000000000000000000000000000000000000000000002498 224.0
HFD2_k127_1012842_3 PFAM Cytochrome c oxidase, subunit I K04561 - 1.7.2.5 0.00000000000000000000000000000000000000000000000000004713 194.0
HFD2_k127_1012842_4 cytochrome c K02305 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000003135 144.0
HFD2_k127_1013252_0 COG1680 Beta-lactamase class C and other penicillin binding proteins K01286 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 406.0
HFD2_k127_1013252_1 Multicopper oxidase K00368 - 1.7.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000005877 272.0
HFD2_k127_1013252_2 Oligoendopeptidase f - - - 0.0000004799 63.0
HFD2_k127_1016818_0 ABC transporter, ATP-binding protein K01990,K09691,K09693 - 3.6.3.40 0.00000000000000000000000000000000000000000000000000000000000000006733 230.0
HFD2_k127_1016818_1 ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000000000000007146 173.0
HFD2_k127_1022777_0 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 359.0
HFD2_k127_1022777_1 pfkB family carbohydrate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004788 354.0
HFD2_k127_1022777_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007093 332.0
HFD2_k127_1022777_3 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 284.0
HFD2_k127_1022777_4 Lumazine binding domain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000001325 185.0
HFD2_k127_1022777_5 - - - - 0.00000000000000000004722 101.0
HFD2_k127_1024604_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 2.283e-277 860.0
HFD2_k127_1024604_1 3-phosphoshikimate 1-carboxyvinyltransferase activity K00800 GO:0003674,GO:0003824,GO:0003866,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:0071944,GO:1901576 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009509 367.0
HFD2_k127_1024604_2 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001694 278.0
HFD2_k127_1024604_3 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.000000000000000000000000000000000000000001435 166.0
HFD2_k127_1024604_4 PFAM NHL repeat containing protein K13735 - - 0.00006758 55.0
HFD2_k127_102668_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 325.0
HFD2_k127_102668_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000003547 99.0
HFD2_k127_102984_0 heavy metal translocating P-type ATPase K01533 - 3.6.3.4 1.644e-252 792.0
HFD2_k127_102984_1 Glycine cleavage T-protein C-terminal barrel domain K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006369 447.0
HFD2_k127_102984_2 Cation transport ATPase (P-type) K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000584 287.0
HFD2_k127_1030939_0 TonB dependent receptor - - - 5.401e-214 701.0
HFD2_k127_1030939_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 310.0
HFD2_k127_1030939_2 cell adhesion involved in biofilm formation - - - 0.00000000000000000000000000000000000000000000000000000001502 215.0
HFD2_k127_1030939_3 TPM domain K06872 - - 0.000000000000000000000000000000000006718 147.0
HFD2_k127_1030939_4 LemA family K03744 - - 0.00000000000000000000176 96.0
HFD2_k127_1030939_5 tRNA cytidylyltransferase activity - - - 0.000000000009117 74.0
HFD2_k127_1030939_6 PFAM TonB-dependent Receptor Plug K21573 - - 0.000004676 56.0
HFD2_k127_1052555_0 - - - - 0.0000000000000000000000000000000000000000000000000000001194 204.0
HFD2_k127_1052555_1 Biotin-lipoyl like K07799 - - 0.0000000000000000000000000000000000000007406 155.0
HFD2_k127_1052555_2 - - - - 0.00000000000001971 86.0
HFD2_k127_1071394_0 Penicillin binding protein transpeptidase domain K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 442.0
HFD2_k127_1071394_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 302.0
HFD2_k127_1071394_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 291.0
HFD2_k127_1071394_3 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003177 284.0
HFD2_k127_1071394_4 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.00000000000000000000000000000000001841 141.0
HFD2_k127_1071394_5 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000002137 125.0
HFD2_k127_1071394_6 Two component signalling adaptor domain K03408 - - 0.0000000000000000000000001329 118.0
HFD2_k127_1071394_7 Two component signalling adaptor domain K03408 - - 0.00000000001587 77.0
HFD2_k127_1071394_8 - - - - 0.00002869 48.0
HFD2_k127_1074162_0 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 307.0
HFD2_k127_1074162_1 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000004003 87.0
HFD2_k127_1074162_2 ThiS family K03154 - - 0.0000000000002318 74.0
HFD2_k127_1074162_3 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000328 64.0
HFD2_k127_1074162_4 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788,K10810 - 2.5.1.3,5.3.99.10 0.0000002805 57.0
HFD2_k127_1074162_5 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0040007,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.0008989 42.0
HFD2_k127_1075859_0 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 490.0
HFD2_k127_1075859_1 Putative neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000605 340.0
HFD2_k127_1075859_2 Anthranilate synthase K01665 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006237 285.0
HFD2_k127_1075859_3 Amino-transferase class IV K00826 - 2.6.1.42 0.000000000000000002202 94.0
HFD2_k127_1075859_4 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.00000005252 61.0
HFD2_k127_1078686_0 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 396.0
HFD2_k127_1078686_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.000000000000000000000000000000000000000001129 178.0
HFD2_k127_1078686_2 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000003059 127.0
HFD2_k127_1082558_0 Glycosyl hydrolase 36 superfamily, catalytic domain K00702,K13688 - 2.4.1.20 0.0 2837.0
HFD2_k127_1091392_0 transmembrane transporter activity K18138 - - 0.0 1619.0
HFD2_k127_1091392_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 408.0
HFD2_k127_1091392_2 efflux transmembrane transporter activity K18300,K18308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 383.0
HFD2_k127_1091392_3 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000408 168.0
HFD2_k127_1091392_4 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000002128 65.0
HFD2_k127_1091392_5 Ig domain protein group 1 domain protein - - - 0.00000001143 63.0
HFD2_k127_1091392_6 - - - - 0.0009052 47.0
HFD2_k127_1093841_0 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 591.0
HFD2_k127_1093841_1 N,N-dimethylaniline monooxygenase activity K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 481.0
HFD2_k127_1093841_2 Protein of unknown function (DUF2167) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000146 280.0
HFD2_k127_1093841_3 DinB superfamily - - - 0.00000000000000000000004889 99.0
HFD2_k127_1097564_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1581.0
HFD2_k127_1097564_1 UDP binding domain K13015 - 1.1.1.136 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 554.0
HFD2_k127_1097564_10 O-acyltransferase activity K13018 - 2.3.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000002801 276.0
HFD2_k127_1097564_11 cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000001052 247.0
HFD2_k127_1097564_12 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000000000001557 211.0
HFD2_k127_1097564_13 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000005513 222.0
HFD2_k127_1097564_14 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000001465 196.0
HFD2_k127_1097564_15 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000000000002802 188.0
HFD2_k127_1097564_16 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000001938 164.0
HFD2_k127_1097564_17 Ribosomal protein L17 K02879 - - 0.000000000000000000000000000000000002059 140.0
HFD2_k127_1097564_18 Nad-dependent epimerase dehydratase K15856,K22252 - 1.1.1.135,1.1.1.281 0.000000000000000000000000000000002351 147.0
HFD2_k127_1097564_19 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000003007 98.0
HFD2_k127_1097564_2 Fumarase C C-terminus K01744 - 4.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005365 512.0
HFD2_k127_1097564_20 Ribosomal protein L36 K02919 - - 0.0000000000002624 70.0
HFD2_k127_1097564_3 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 488.0
HFD2_k127_1097564_4 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 486.0
HFD2_k127_1097564_5 domain protein K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 475.0
HFD2_k127_1097564_6 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008723 466.0
HFD2_k127_1097564_7 Oxidoreductase family, NAD-binding Rossmann fold K13018 - 2.3.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 320.0
HFD2_k127_1097564_8 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000275 304.0
HFD2_k127_1097564_9 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006516 302.0
HFD2_k127_1122885_0 E1-E2 ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004684 477.0
HFD2_k127_1122885_1 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006724 346.0
HFD2_k127_1122885_2 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003254 254.0
HFD2_k127_1122885_3 Histidine kinase K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000001829 214.0
HFD2_k127_1122885_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07644 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000001409 209.0
HFD2_k127_1122885_5 CoA binding domain - - - 0.000000000000000000000000000000001233 145.0
HFD2_k127_1122885_6 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00004157 53.0
HFD2_k127_1123590_0 ATP binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006358 341.0
HFD2_k127_1123590_1 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000007164 120.0
HFD2_k127_1147199_0 cAMP biosynthetic process K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 520.0
HFD2_k127_1147199_1 PFAM AMP-dependent synthetase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 285.0
HFD2_k127_1147199_2 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738,K01883,K12339 - 2.5.1.47,6.1.1.16 0.0000000000000000000000006841 110.0
HFD2_k127_1148526_0 RNA polymerase binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 342.0
HFD2_k127_1148526_1 Peptidase M28 - - - 0.000000000000000000000000000000000000000000000001364 184.0
HFD2_k127_1152212_0 Response regulator receiver - - - 5.243e-195 618.0
HFD2_k127_1152212_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006321 489.0
HFD2_k127_1152212_2 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009472 368.0
HFD2_k127_1152212_3 Protein kinase domain K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000001943 214.0
HFD2_k127_1152212_4 23S rRNA-intervening sequence protein - - - 0.00000000000000000000000000000002548 132.0
HFD2_k127_1152212_5 secondary active sulfate transmembrane transporter activity - - - 0.0000000000000001907 88.0
HFD2_k127_1152212_6 Protein of unknown function (DUF1569) - - - 0.0000004437 60.0
HFD2_k127_1156748_0 Transporter associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 299.0
HFD2_k127_1156748_1 Cation efflux family K16264 - - 0.0000000000000000000000000002159 131.0
HFD2_k127_1197160_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002171 477.0
HFD2_k127_1197160_1 Bacterial Ig-like domain - - - 0.0000000000000000000000001261 124.0
HFD2_k127_1200156_0 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01667,K01668 - 4.1.99.1,4.1.99.2 3.647e-204 645.0
HFD2_k127_1200156_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K09461 - 1.14.13.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 496.0
HFD2_k127_1200156_2 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009394 471.0
HFD2_k127_1200156_3 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000896 267.0
HFD2_k127_1200156_4 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.000000000000000000000000000000000000000000000000001585 190.0
HFD2_k127_1200156_5 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.00000000000000000000000000000000000000002289 162.0
HFD2_k127_1200156_6 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000167 128.0
HFD2_k127_1200156_7 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0000000000000000000000000001639 117.0
HFD2_k127_1200156_8 - - - - 0.000000000001111 74.0
HFD2_k127_1200156_9 Recombinase zinc beta ribbon domain K06400 - - 0.00001591 47.0
HFD2_k127_1200452_0 Sodium:solute symporter family K14393 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003868 511.0
HFD2_k127_1200452_1 - - - - 0.00000000000000000000000000000000000004291 158.0
HFD2_k127_1200452_2 Membrane - - - 0.00000001611 64.0
HFD2_k127_120686_0 COG0433 Predicted ATPase K06915 - - 2.934e-209 660.0
HFD2_k127_120686_1 AAA domain K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007312 568.0
HFD2_k127_120686_2 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005893 342.0
HFD2_k127_120686_3 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006148 327.0
HFD2_k127_120686_4 Arsenical pump membrane protein - - - 0.00000000000000000000000000000000000000001007 159.0
HFD2_k127_1208793_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1023.0
HFD2_k127_1208793_1 Tetratricopeptide repeat K08309 - - 0.0000000000000000000000000000000000168 148.0
HFD2_k127_1208793_2 Cold shock K03704 - - 0.00000000000000000000000000000003369 130.0
HFD2_k127_1208793_3 Prokaryotic N-terminal methylation motif - - - 0.00000000177 59.0
HFD2_k127_120931_0 Beta-L-arabinofuranosidase, GH127 K09955 - - 8.428e-201 647.0
HFD2_k127_120931_1 hydrolase activity, hydrolyzing O-glycosyl compounds K00689 GO:0005575,GO:0005576 2.4.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 414.0
HFD2_k127_120931_2 PFAM VanZ like family - - - 0.00007111 51.0
HFD2_k127_1210970_0 PFAM alpha beta hydrolase fold - - - 0.00000000000000000000000000000008902 141.0
HFD2_k127_1210970_1 Bacterial regulatory proteins, tetR family K09017 - - 0.00000000000000008277 89.0
HFD2_k127_1210970_2 Sugar-specific transcriptional regulator TrmB - - - 0.000000005018 66.0
HFD2_k127_1210970_3 - - - - 0.000007018 51.0
HFD2_k127_1211751_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 452.0
HFD2_k127_1211751_1 Cellulose biosynthesis protein BcsQ K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 346.0
HFD2_k127_1211751_2 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003123 256.0
HFD2_k127_1233603_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07306,K08352 - 1.8.5.3,1.8.5.5 6.564e-244 769.0
HFD2_k127_1233603_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 357.0
HFD2_k127_1233603_2 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 339.0
HFD2_k127_1233603_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 325.0
HFD2_k127_1233603_4 Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells K03649 - 3.2.2.28 0.00000000000000000000000000000000000000000000000000000000000000007064 238.0
HFD2_k127_1233603_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000335 221.0
HFD2_k127_1233603_6 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000323 121.0
HFD2_k127_1233603_7 HAD-hyrolase-like - - - 0.0000000000000000000001151 108.0
HFD2_k127_1233603_9 Domain of unknown function (DUF4440) - - - 0.0000001856 60.0
HFD2_k127_123820_0 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006787 262.0
HFD2_k127_123820_2 transcriptional regulator - - - 0.00000000000000000000000000185 119.0
HFD2_k127_123820_3 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000006871 99.0
HFD2_k127_1256477_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 612.0
HFD2_k127_1256477_1 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000261 492.0
HFD2_k127_1256477_2 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006869 370.0
HFD2_k127_1256477_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 362.0
HFD2_k127_1256477_4 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 375.0
HFD2_k127_1256477_5 Aminoacyl tRNA synthetase class II, N-terminal domain K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 355.0
HFD2_k127_1256477_6 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000002201 241.0
HFD2_k127_1256477_7 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.00000000000000000000000000000000000000000000004488 171.0
HFD2_k127_1256477_8 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.00000000000000008128 86.0
HFD2_k127_1256477_9 Ribosomal protein L35 K02916 - - 0.000000001061 64.0
HFD2_k127_1268232_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006386 544.0
HFD2_k127_1268232_1 PFAM binding-protein-dependent transport systems inner membrane component K05773 - - 0.00000000000000000000000000000000000000000000000000002424 203.0
HFD2_k127_1268232_2 - - - - 0.00000000000003595 82.0
HFD2_k127_1282167_0 Aldehyde dehydrogenase family K00128 - 1.2.1.3 3.331e-223 702.0
HFD2_k127_1282167_1 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 496.0
HFD2_k127_1282167_2 Calcineurin-like phosphoesterase K03269 - 3.6.1.54 0.0000000000000000000000000003132 119.0
HFD2_k127_13066_0 Dihydrodipicolinate synthetase family - - - 0.0000000000000000000000472 104.0
HFD2_k127_13066_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000006871 88.0
HFD2_k127_1316714_0 Tricorn protease PDZ domain K08676 - - 0.0 1528.0
HFD2_k127_1316714_1 beta-galactosidase activity K01190 - 3.2.1.23 1.749e-247 797.0
HFD2_k127_1316714_2 Glycogen debranching enzyme, glucanotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 371.0
HFD2_k127_1316714_3 hydroperoxide reductase activity - - - 0.000000000000000000000000000004446 122.0
HFD2_k127_1316714_4 hydroperoxide reductase activity - - - 0.000000000000000000003341 97.0
HFD2_k127_1321314_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000092 460.0
HFD2_k127_1321314_1 Rhodanese Homology Domain K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007112 342.0
HFD2_k127_132137_0 - - - - 0.000000000000000000000000000005052 126.0
HFD2_k127_132137_1 Di-haem oxidoreductase, putative peroxidase - - - 0.000000000000000000003708 96.0
HFD2_k127_1343503_0 Atp-dependent helicase - - - 6.2e-314 982.0
HFD2_k127_1343503_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 468.0
HFD2_k127_1343503_2 methyl-accepting chemotaxis protein K03406 - - 0.000000000000000002525 100.0
HFD2_k127_1343503_3 Belongs to the ompA family K03286 - - 0.000000000000007695 89.0
HFD2_k127_1343503_4 Rdx family K07401 - - 0.0000000001802 63.0
HFD2_k127_1343503_5 Kelch repeat-containing protein - - - 0.00001774 58.0
HFD2_k127_134605_0 PFAM glycosyl hydrolase BNR repeat-containing protein - - - 7.845e-226 718.0
HFD2_k127_1351046_0 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000002047 228.0
HFD2_k127_1351046_1 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.00000000000000000000000000000000000000000000000000000000000007763 220.0
HFD2_k127_1351046_2 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.0000000000000000000000000000000005298 141.0
HFD2_k127_1351046_3 Curli production assembly/transport component CsgG - - - 0.00000000000000000000000000000008241 136.0
HFD2_k127_1351046_4 Binds the 23S rRNA K02909 - - 0.000000000000000000000001205 105.0
HFD2_k127_1351046_5 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.0000000000199 73.0
HFD2_k127_1353132_0 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 424.0
HFD2_k127_1353132_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003401 345.0
HFD2_k127_1353132_2 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000000007693 185.0
HFD2_k127_1381729_0 AcrB/AcrD/AcrF family K07787,K15726 - - 0.0 1302.0
HFD2_k127_1381729_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 327.0
HFD2_k127_1381729_2 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000009786 145.0
HFD2_k127_1381729_3 efflux transmembrane transporter activity - - - 0.000001164 51.0
HFD2_k127_1422506_0 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 401.0
HFD2_k127_1422506_1 - - - - 0.000000000000000000000002635 111.0
HFD2_k127_1434596_0 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 397.0
HFD2_k127_1434596_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000007265 266.0
HFD2_k127_1434596_2 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.00000000000000000000000000000000000001773 153.0
HFD2_k127_153757_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007079 499.0
HFD2_k127_153757_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 414.0
HFD2_k127_153757_2 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000007185 120.0
HFD2_k127_155224_0 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003258 421.0
HFD2_k127_155224_1 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 297.0
HFD2_k127_155224_2 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000554 270.0
HFD2_k127_155224_3 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000007005 244.0
HFD2_k127_155224_4 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000001641 165.0
HFD2_k127_155224_5 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000004779 148.0
HFD2_k127_155224_6 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000003524 81.0
HFD2_k127_1566605_0 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 563.0
HFD2_k127_1566605_1 Cell cycle protein K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 456.0
HFD2_k127_1566605_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006142 389.0
HFD2_k127_1566605_3 rod shape-determining protein MreD K03571 - - 0.0000000000000000000000000001551 121.0
HFD2_k127_161976_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 326.0
HFD2_k127_161976_1 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000007691 259.0
HFD2_k127_161976_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000008372 271.0
HFD2_k127_161976_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000006906 264.0
HFD2_k127_161976_4 Adenylosuccinate lyase C-terminus K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000004657 222.0
HFD2_k127_1755421_0 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005432 556.0
HFD2_k127_1755421_1 Cold shock K03704 - - 0.0000000000000000000000000000001575 124.0
HFD2_k127_1755421_2 domain protein K13735,K20276 - - 0.00000000008993 74.0
HFD2_k127_1760397_0 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 471.0
HFD2_k127_1760397_1 P2 response regulator binding domain K03407 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 457.0
HFD2_k127_1760397_10 Prokaryotic dksA/traR C4-type zinc finger - - - 0.0000000000000000000000000000000000000000000000000000000000003311 214.0
HFD2_k127_1760397_11 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000000000004448 170.0
HFD2_k127_1760397_12 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000003163 153.0
HFD2_k127_1760397_13 isoleucyl-tRNA aminoacylation K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 0.0000000000000000000000002964 105.0
HFD2_k127_1760397_14 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.000000000000000000009898 105.0
HFD2_k127_1760397_15 Roadblock/LC7 domain - - - 0.0000000004471 67.0
HFD2_k127_1760397_16 CheW-like domain - - - 0.0001203 51.0
HFD2_k127_1760397_17 Roadblock/LC7 domain K07131 - - 0.0001936 52.0
HFD2_k127_1760397_18 Tetratricopeptide repeat - - - 0.000572 52.0
HFD2_k127_1760397_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000361 460.0
HFD2_k127_1760397_3 Bacterial dnaA protein K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009417 439.0
HFD2_k127_1760397_4 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 361.0
HFD2_k127_1760397_5 Small GTP-binding protein K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005656 282.0
HFD2_k127_1760397_6 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001411 290.0
HFD2_k127_1760397_7 CheC-like family K03410 - - 0.000000000000000000000000000000000000000000000000000000000000000004645 231.0
HFD2_k127_1760397_8 protein-glutamate O-methyltransferase activity K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000001714 246.0
HFD2_k127_1760397_9 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000000000000000000000000000003285 218.0
HFD2_k127_1763162_0 AcrB/AcrD/AcrF family - - - 2.071e-240 760.0
HFD2_k127_1763162_1 cation efflux system protein (Heavy metal efflux pump) - - - 2.182e-220 707.0
HFD2_k127_1763162_2 - - - - 0.0000000000000000000002635 102.0
HFD2_k127_176561_0 heat shock protein binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006808 243.0
HFD2_k127_1769086_0 Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002665 286.0
HFD2_k127_1769086_1 Protein involved in formate dehydrogenase formation K02380 - - 0.000000000000000000000000000000000000000000000000000007588 201.0
HFD2_k127_1769086_2 - - - - 0.0000000000000000001413 96.0
HFD2_k127_1769086_3 4Fe-4S binding domain K00124 - - 0.000000000006262 66.0
HFD2_k127_1769086_4 - - - - 0.0001323 54.0
HFD2_k127_1775638_0 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000006602 216.0
HFD2_k127_1775638_1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000008144 175.0
HFD2_k127_1775638_2 Domain of unknown function (DUF374) K09778 - - 0.0000000000000000000000000000000000001401 153.0
HFD2_k127_1775638_3 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.00000000000000000000379 96.0
HFD2_k127_1775995_0 Sortilin, neurotensin receptor 3, - - - 2.747e-206 664.0
HFD2_k127_177770_0 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 3.571e-232 732.0
HFD2_k127_177770_1 Polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000000001584 145.0
HFD2_k127_177770_2 Glycosyl transferases group 1 - - - 0.000000000000248 75.0
HFD2_k127_177770_3 lysyltransferase activity K07027 - - 0.00005459 55.0
HFD2_k127_1783585_0 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006366 414.0
HFD2_k127_1783585_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 405.0
HFD2_k127_1783585_2 Transcriptional regulatory protein, C terminal K02483,K07665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000281 318.0
HFD2_k127_1783585_3 COG0348 Polyferredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008022 291.0
HFD2_k127_1783585_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001884 283.0
HFD2_k127_1783585_5 cytochrome oxidase maturation protein cbb3-type - - - 0.00005595 55.0
HFD2_k127_1786996_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 2.714e-274 857.0
HFD2_k127_1786996_1 cellulose binding - - - 0.000000004353 59.0
HFD2_k127_1790693_0 Glycolate oxidase subunit GlcE K11472 - - 0.0000000000000000000000000000000000000001487 165.0
HFD2_k127_1790693_1 4Fe-4S binding domain K11473 - - 0.000000000000000000000000000000000000459 149.0
HFD2_k127_1796156_0 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000005799 235.0
HFD2_k127_1796156_1 Belongs to the peptidase S8 family - - - 0.000000000005666 80.0
HFD2_k127_1798854_0 - - - - 0.00000000000000000000000000000000000000000000000000000002558 220.0
HFD2_k127_1798854_1 Domain of unknown function (DUF4442) - - - 0.0004171 51.0
HFD2_k127_1799412_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005793 574.0
HFD2_k127_1799412_1 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008441 317.0
HFD2_k127_1799412_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001038 273.0
HFD2_k127_1799412_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000127 166.0
HFD2_k127_1801311_0 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 391.0
HFD2_k127_1801311_1 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 300.0
HFD2_k127_1801311_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000001175 157.0
HFD2_k127_1801311_3 BON domain - - - 0.0000000000001203 76.0
HFD2_k127_1802658_0 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.000000000000000000000000000000000000000000000000000000000000000000000000008159 264.0
HFD2_k127_1802658_1 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000001854 237.0
HFD2_k127_1802658_2 Mazg nucleotide pyrophosphohydrolase K00800 - 2.5.1.19 0.0000000000000000000000000000000000000003254 152.0
HFD2_k127_1802658_3 - - - - 0.0000000000002376 73.0
HFD2_k127_1802658_4 - - - - 0.00000000006104 66.0
HFD2_k127_1807055_0 Sodium:solute symporter family - - - 8.978e-275 853.0
HFD2_k127_1807055_1 PFAM Glycoside hydrolase, family 20, catalytic core K12373 - 3.2.1.52 2.179e-204 656.0
HFD2_k127_1807055_2 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.0000000001271 64.0
HFD2_k127_1809048_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 7.38e-283 894.0
HFD2_k127_1809048_1 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000000000000000000000000000000000000000000000000000000000001279 214.0
HFD2_k127_1809048_2 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000004891 156.0
HFD2_k127_1809527_0 tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 573.0
HFD2_k127_1809527_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008945 345.0
HFD2_k127_1809527_2 PQQ-like domain K17713 - - 0.00000000000003091 87.0
HFD2_k127_1809527_3 - - - - 0.000000001414 65.0
HFD2_k127_1810261_0 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 472.0
HFD2_k127_1810261_1 Putative esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 301.0
HFD2_k127_1810261_2 dimethylhistidine N-methyltransferase activity K18911 - 2.1.1.44 0.0000000000000000000000000000000000000000000000000000000003869 219.0
HFD2_k127_1810261_3 Aldo/keto reductase family K06607 - - 0.000000000000000000000000000000000000000000000000001223 198.0
HFD2_k127_1810261_4 Beta-lactamase - - - 0.000000000000000000000000000000003781 133.0
HFD2_k127_1810261_5 belongs to the UPF0276 family K09930 - - 0.00000000000000332 85.0
HFD2_k127_1810261_6 ABC transporter K05847 - - 0.0001104 48.0
HFD2_k127_1819338_0 Creatinase/Prolidase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000001474 232.0
HFD2_k127_1819338_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000002383 188.0
HFD2_k127_1819338_2 COGs COG2380 conserved K09785 - - 0.00000000000000000000000000003173 133.0
HFD2_k127_1821642_0 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000001799 118.0
HFD2_k127_1821642_1 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.0000000005616 67.0
HFD2_k127_1825497_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004531 407.0
HFD2_k127_1825497_1 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000001947 258.0
HFD2_k127_1825497_2 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000004359 139.0
HFD2_k127_1825497_3 GHMP kinase - - - 0.000000001868 70.0
HFD2_k127_1832174_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016020,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0040007,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 7.533e-195 615.0
HFD2_k127_1832174_1 Enoyl-CoA hydratase K07539,K18570 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.0000000000000000000000000000000000000000007658 166.0
HFD2_k127_1832174_2 PFAM Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000005904 147.0
HFD2_k127_1832174_3 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000003705 141.0
HFD2_k127_1832174_4 protein with SCP PR1 domains - - - 0.0000000000000000000000000009515 118.0
HFD2_k127_1832174_5 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.000000000000000000001003 104.0
HFD2_k127_1837455_0 Heparinase II/III-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005243 426.0
HFD2_k127_1837455_1 GHMP kinase - - - 0.000000000000000000000000000000000000000000000000002314 192.0
HFD2_k127_1837741_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.586e-247 788.0
HFD2_k127_1844714_0 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 460.0
HFD2_k127_1844714_1 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000004511 265.0
HFD2_k127_1844714_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007268 274.0
HFD2_k127_1844714_3 PFAM Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000006542 239.0
HFD2_k127_1844714_4 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000001143 202.0
HFD2_k127_1844714_5 Protein of unknown function (DUF456) K09793 - - 0.00000000000000000000000000000001117 133.0
HFD2_k127_1844714_6 ferredoxin-NADP+ reductase activity - - - 0.0000000000000001725 86.0
HFD2_k127_1863656_0 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004043 484.0
HFD2_k127_1863656_1 Glycosyl transferases group 1 K13668 - 2.4.1.346 0.000000000000000000000000000000000000000000000000000146 201.0
HFD2_k127_1863656_2 glycosyl transferase group 1 K13668 - 2.4.1.346 0.00000000000000000000000000000000000000000000000005177 196.0
HFD2_k127_1863656_3 Glycosyl transferase family 2 K12984 - - 0.000000000000000000000000000000000000000000002413 171.0
HFD2_k127_1871567_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005392 580.0
HFD2_k127_1871567_1 V-type ATPase 116kDa subunit family K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004927 280.0
HFD2_k127_1871567_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.000000000000000000000003579 105.0
HFD2_k127_1871567_3 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.000000000001076 80.0
HFD2_k127_1871567_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000004444 72.0
HFD2_k127_1871567_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131 - 0.00000005133 63.0
HFD2_k127_1871567_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000004375 56.0
HFD2_k127_1874212_0 LVIVD repeat - - - 6.984e-242 763.0
HFD2_k127_1874212_1 Penicillin amidase - - - 0.000000000000000000000000000000000000000000000005067 173.0
HFD2_k127_1874549_0 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005011 548.0
HFD2_k127_1874549_1 Transcriptional regulatory protein, C terminal K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006136 290.0
HFD2_k127_1874549_2 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000007077 178.0
HFD2_k127_1874549_3 DNA-binding transcription factor activity K03892 GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0046685,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.000003272 61.0
HFD2_k127_1882126_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 8.249e-223 696.0
HFD2_k127_1882126_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006872 485.0
HFD2_k127_1882126_2 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00240,K00245 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 393.0
HFD2_k127_1882126_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639,K20967 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0040007,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0071944,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 0.000000000000000000000000000000000000000000004102 166.0
HFD2_k127_190415_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 500.0
HFD2_k127_190415_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000001507 106.0
HFD2_k127_1907883_0 GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006163 283.0
HFD2_k127_1907883_1 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000001693 218.0
HFD2_k127_1907883_2 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000000004241 193.0
HFD2_k127_1907883_3 Peptidase family M23 K19304 GO:0000270,GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0006022,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008219,GO:0008233,GO:0008237,GO:0009987,GO:0012501,GO:0016787,GO:0019538,GO:0030203,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901564 - 0.00000000000001026 88.0
HFD2_k127_1917342_0 radical SAM domain protein - - - 1.101e-225 709.0
HFD2_k127_1917342_1 Divalent cation transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004554 550.0
HFD2_k127_1917342_2 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 529.0
HFD2_k127_1917342_3 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 472.0
HFD2_k127_1917342_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005038 404.0
HFD2_k127_1917342_5 lipoprotein transporter activity K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007677 338.0
HFD2_k127_1917342_6 Protein of unknown function (DUF445) - - - 0.00000000000000000000000000000002846 130.0
HFD2_k127_1917342_7 Belongs to the universal stress protein A family - - - 0.0000000005008 70.0
HFD2_k127_1924223_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 625.0
HFD2_k127_1924223_1 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008035 530.0
HFD2_k127_1924223_2 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 390.0
HFD2_k127_1924223_3 Elongator protein 3, MiaB family, Radical SAM K22226,K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 374.0
HFD2_k127_1924223_4 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004567 287.0
HFD2_k127_1924223_5 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004902 285.0
HFD2_k127_1924223_6 M61 glycyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000003633 198.0
HFD2_k127_1925720_0 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 601.0
HFD2_k127_1925720_1 Regulator of chromosome condensation (RCC1) repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002766 269.0
HFD2_k127_1925720_2 COGs COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.0000000000000000000000000000000000000000000000000007354 190.0
HFD2_k127_1934779_0 NmrA-like family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000002121 216.0
HFD2_k127_1934779_1 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000008342 192.0
HFD2_k127_1934779_2 PAP2 superfamily - - - 0.000000000000009848 87.0
HFD2_k127_1941505_0 Hydrogenase formation hypA family K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002204 266.0
HFD2_k127_1941505_1 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.000000000000000000000000000000000000000000000000000000000000009341 223.0
HFD2_k127_1941505_2 Hemerythrin HHE cation binding K07322 - - 0.000000000000000000000000000000000000000000147 165.0
HFD2_k127_1941505_3 carbon dioxide binding K04653,K04654 - - 0.00000000000000000000000000000009049 126.0
HFD2_k127_1941505_4 hydrogenase maturation protease K03605 - - 0.00000000000000004 84.0
HFD2_k127_1941505_5 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.00009894 49.0
HFD2_k127_1942671_0 PFAM Na dependent nucleoside transporter K03317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 451.0
HFD2_k127_1942671_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000004803 231.0
HFD2_k127_1942671_2 Cytochrome C oxidase, cbb3-type, subunit III K19713 - 1.8.2.2 0.00000000000000000000000000000000000000000000000000000000000001112 239.0
HFD2_k127_1942671_3 transport - - - 0.000004603 53.0
HFD2_k127_1947442_0 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001269 269.0
HFD2_k127_1947442_1 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000746 151.0
HFD2_k127_1947442_2 Periplasmic component of the Tol biopolymer transport system - - - 0.00000000000000000000000001597 113.0
HFD2_k127_1951212_0 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 464.0
HFD2_k127_1951212_1 PFAM NADP oxidoreductase coenzyme F420-dependent - - - 0.00000000000000000000000000000000000273 158.0
HFD2_k127_1951212_2 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000000000000000000000002989 147.0
HFD2_k127_1951212_3 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.0000000000000000000000000000002491 131.0
HFD2_k127_1951212_4 Control of competence regulator ComK, YlbF/YmcA - - - 0.00000839 48.0
HFD2_k127_1951212_5 PFAM DAHP synthetase I K03856 - 2.5.1.54 0.0008989 42.0
HFD2_k127_1961383_0 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 421.0
HFD2_k127_1961383_1 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 339.0
HFD2_k127_1961383_2 PFAM Rieske 2Fe-2S domain protein K00479,K00499 - 1.14.15.7 0.000003126 53.0
HFD2_k127_1963119_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 358.0
HFD2_k127_1963119_1 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000001136 194.0
HFD2_k127_1963119_2 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000000003964 173.0
HFD2_k127_1972570_0 - - - - 5.102e-254 814.0
HFD2_k127_1972570_1 homoserine kinase activity K02204,K13059 - 2.7.1.162,2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008287 328.0
HFD2_k127_1972570_2 Nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001556 256.0
HFD2_k127_1977256_0 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 583.0
HFD2_k127_1977256_1 tRNA (Uracil-5-)-methyltransferase K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000004974 274.0
HFD2_k127_1977256_2 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000163 189.0
HFD2_k127_1977256_3 Biotin-requiring enzyme - - - 0.00000000000000000000000002054 120.0
HFD2_k127_1977256_4 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 0.0000000000000000002328 87.0
HFD2_k127_1977256_5 Ribosomal protein S9/S16 K02996 - - 0.000000002217 63.0
HFD2_k127_1981942_0 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 484.0
HFD2_k127_1981942_1 oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 370.0
HFD2_k127_1981942_2 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 360.0
HFD2_k127_1981942_3 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000009521 117.0
HFD2_k127_1981942_4 Alpha/beta hydrolase family - - - 0.000000000000006788 85.0
HFD2_k127_1981942_5 cyclic nucleotide-binding K10914 - - 0.0000068 53.0
HFD2_k127_1995272_0 Predicted permease YjgP/YjgQ family K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000171 275.0
HFD2_k127_1999953_0 3'-5' exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001827 371.0
HFD2_k127_1999953_1 Ndr family - - - 0.0000000000000000000000000000000000000000000000000000000007638 210.0
HFD2_k127_1999953_2 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000399 169.0
HFD2_k127_1999953_3 Bacterial regulatory proteins, tetR family - - - 0.0000000000006248 72.0
HFD2_k127_2002180_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1192.0
HFD2_k127_2002180_1 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 336.0
HFD2_k127_2002180_2 Putative ABC exporter - - - 0.00000000000000000000000000000000000000000000000000000001303 219.0
HFD2_k127_2002180_3 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.000000000000000000000000000000000000000000000000001478 196.0
HFD2_k127_2002180_4 - - - - 0.000000000000000000000000000000000000000004019 167.0
HFD2_k127_2012390_0 Glycogen debranching enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 548.0
HFD2_k127_2012390_1 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008505 537.0
HFD2_k127_2012390_2 radical SAM domain protein - - - 0.000000000000000000000000000000000000004664 157.0
HFD2_k127_2012390_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000002356 166.0
HFD2_k127_2012390_4 Calcium/calmodulin dependent protein kinase II association domain - - - 0.0000000000000000000006176 103.0
HFD2_k127_2051645_0 COG1055 Na H antiporter NhaD and related arsenite - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 483.0
HFD2_k127_2051645_1 NAD synthase K01916 - 6.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007181 347.0
HFD2_k127_2051645_2 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000003379 186.0
HFD2_k127_2051645_3 4Fe-4S single cluster domain K07001 - - 0.0000000000000000000000001161 115.0
HFD2_k127_2059268_0 ATPases associated with a variety of cellular activities K16786,K16787 - - 0.0000000000000000000000000000000000000000000001803 176.0
HFD2_k127_2083810_0 amine dehydrogenase activity K17285 - - 3.103e-233 739.0
HFD2_k127_2083810_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 567.0
HFD2_k127_2083810_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000747 216.0
HFD2_k127_2083810_3 ECF sigma factor - - - 0.0000000000000000000000000000000000000000000000000000002652 200.0
HFD2_k127_2083810_4 - - - - 0.0000000000000000000000000000003835 139.0
HFD2_k127_2083810_5 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000211 118.0
HFD2_k127_2096876_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 518.0
HFD2_k127_2096876_1 Peptidase family S41 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007729 374.0
HFD2_k127_2096876_10 - - - - 0.000000000000000000000000000009146 121.0
HFD2_k127_2096876_11 Lanthionine synthetase C family protein - - - 0.000000000000000000000000000498 123.0
HFD2_k127_2096876_13 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000005304 61.0
HFD2_k127_2096876_15 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000002167 58.0
HFD2_k127_2096876_16 Copper binding proteins, plastocyanin/azurin family - - - 0.000007965 58.0
HFD2_k127_2096876_2 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001244 273.0
HFD2_k127_2096876_3 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000001406 261.0
HFD2_k127_2096876_4 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000000000000000000001899 195.0
HFD2_k127_2096876_5 NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000273 181.0
HFD2_k127_2096876_6 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000003569 153.0
HFD2_k127_2096876_7 Peptidyl-prolyl cis-trans isomerase K01802,K03772,K03773 - 5.2.1.8 0.00000000000000000000000000000000000001576 147.0
HFD2_k127_2096876_8 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000002528 145.0
HFD2_k127_2096876_9 - - - - 0.0000000000000000000000000000001335 138.0
HFD2_k127_2097872_0 lysine 2,3-aminomutase activity K01843 - 5.4.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 451.0
HFD2_k127_2097872_1 TIGRFAM Ammonium transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 368.0
HFD2_k127_2097872_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000005608 199.0
HFD2_k127_2097872_3 Nitrogen regulatory protein P-II K04751 - - 0.000000000000000000000000000000000000000000000000002512 189.0
HFD2_k127_2097872_4 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000002149 135.0
HFD2_k127_2097872_5 ATP-grasp domain K01921 - 6.3.2.4 0.00000000000000000000003065 100.0
HFD2_k127_209938_0 HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 331.0
HFD2_k127_2104816_0 Glycosyl transferase family 21 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005736 288.0
HFD2_k127_2104816_1 H( )-stimulated, divalent metal cation uptake system K03322 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002683 255.0
HFD2_k127_2104816_2 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.00000000000000000000000000000000000000000000000000000000000000001439 231.0
HFD2_k127_2104816_3 thiolester hydrolase activity K01179,K06889,K10773,K15853 - 3.2.1.4,4.2.99.18 0.00000000000000000000000000000000000000000000000000000009684 205.0
HFD2_k127_2104816_4 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000000001407 199.0
HFD2_k127_2104816_5 NUDIX domain - - - 0.00000000000000000000000000000000001032 146.0
HFD2_k127_2104816_6 Belongs to the NiCoT transporter (TC 2.A.52) family - - - 0.00000000000000000000000000000005528 144.0
HFD2_k127_2104816_7 - - - - 0.00000000002691 72.0
HFD2_k127_2113301_0 lysine biosynthetic process via aminoadipic acid - - - 1.073e-236 756.0
HFD2_k127_2113301_1 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000006274 229.0
HFD2_k127_2137502_0 Ftsk_gamma K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 565.0
HFD2_k127_2170383_0 Domain of unknown function (DUF4153) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001273 287.0
HFD2_k127_2170383_1 Amino acid permease K03294,K19540 GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006040,GO:0006082,GO:0006520,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008152,GO:0008509,GO:0008514,GO:0009056,GO:0009063,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0016054,GO:0019752,GO:0022804,GO:0022857,GO:0030389,GO:0030392,GO:0030393,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046348,GO:0046395,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0098656,GO:1901135,GO:1901136,GO:1901281,GO:1901564,GO:1901565,GO:1901575,GO:1902475,GO:1903825,GO:1905039 - 0.00000000000000000000000000000000000000000000000001019 182.0
HFD2_k127_2191893_0 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 405.0
HFD2_k127_2191893_1 3' exoribonuclease, RNase T-like K03656,K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 386.0
HFD2_k127_2191893_2 glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000003486 253.0
HFD2_k127_2191893_3 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000005691 241.0
HFD2_k127_2191893_4 Thioredoxin-like - - - 0.000000000000000000000000000000000001497 155.0
HFD2_k127_2195577_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003872 478.0
HFD2_k127_2195577_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000005774 187.0
HFD2_k127_2197021_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1152.0
HFD2_k127_2197021_1 diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 455.0
HFD2_k127_2197021_2 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007301 308.0
HFD2_k127_2197021_3 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000001543 260.0
HFD2_k127_2197021_4 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000007922 241.0
HFD2_k127_2197021_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000007572 200.0
HFD2_k127_2197021_6 Protein of unknown function (DUF983) - - - 0.00000000004846 66.0
HFD2_k127_219935_0 LysM domain - - - 0.000000000000000000000000000000000000000000000000000000000003233 216.0
HFD2_k127_219935_1 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000005688 203.0
HFD2_k127_219935_2 GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000009812 173.0
HFD2_k127_219935_3 COGs COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs K00375 - - 0.00000000004749 69.0
HFD2_k127_2201985_0 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 292.0
HFD2_k127_2201985_1 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006161 259.0
HFD2_k127_2201985_2 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.200,3.5.1.19,6.1.1.16 0.00000000000000000000000000000000000000000000003871 178.0
HFD2_k127_2228934_0 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000394 154.0
HFD2_k127_2228934_1 Serine aminopeptidase, S33 - - - 0.000000000000000000000001562 111.0
HFD2_k127_2228934_2 Patatin-like phospholipase - - - 0.00000000000006192 81.0
HFD2_k127_2270785_0 PFAM regulator of chromosome condensation, RCC1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004321 267.0
HFD2_k127_2270785_1 Protein of unknown function (DUF3761) - - - 0.0000000000000000006842 92.0
HFD2_k127_2276441_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 526.0
HFD2_k127_2276441_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009571 425.0
HFD2_k127_2276441_10 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000005065 181.0
HFD2_k127_2276441_11 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000001016 165.0
HFD2_k127_2276441_12 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000641 151.0
HFD2_k127_2276441_13 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000009536 145.0
HFD2_k127_2276441_14 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000000005097 143.0
HFD2_k127_2276441_15 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000000000001327 141.0
HFD2_k127_2276441_16 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0008150,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000006396 131.0
HFD2_k127_2276441_17 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.0000000000000000000000000002561 116.0
HFD2_k127_2276441_18 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000001722 98.0
HFD2_k127_2276441_19 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000004055 98.0
HFD2_k127_2276441_2 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003528 359.0
HFD2_k127_2276441_20 Ribosomal protein L30p/L7e K02907 - - 0.0000000000001745 75.0
HFD2_k127_2276441_21 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000006902 59.0
HFD2_k127_2276441_3 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003512 256.0
HFD2_k127_2276441_4 Forms part of the polypeptide exit tunnel K02926 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007392 251.0
HFD2_k127_2276441_5 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005942 252.0
HFD2_k127_2276441_6 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000333 241.0
HFD2_k127_2276441_7 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000009491 231.0
HFD2_k127_2276441_8 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.0000000000000000000000000000000000000000000000000000000000008152 213.0
HFD2_k127_2276441_9 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000003155 201.0
HFD2_k127_2345732_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 9.295e-215 692.0
HFD2_k127_2345732_1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 585.0
HFD2_k127_2345732_2 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 367.0
HFD2_k127_2345732_3 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000005561 262.0
HFD2_k127_2345732_4 Bacillithiol biosynthesis BshC K22136 - - 0.00000000000000000000000000000000000000000000000000000000005413 229.0
HFD2_k127_2345732_5 methyltransferase activity - - - 0.000000000000000000000000000000000000000000000002872 184.0
HFD2_k127_2345732_6 AMMECR1 K09141 - - 0.000000000000000000000000000000000000000009911 160.0
HFD2_k127_2345732_7 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000001733 126.0
HFD2_k127_2348900_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 437.0
HFD2_k127_2348900_1 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007243 250.0
HFD2_k127_2348900_2 PFAM Inosine uridine-preferring nucleoside hydrolase K01250 - - 0.0000000000000000000000000000000000000000000000000001492 197.0
HFD2_k127_2348900_3 3-hydroxyacyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000001929 195.0
HFD2_k127_237178_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 5.633e-228 733.0
HFD2_k127_237178_1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000667 600.0
HFD2_k127_237178_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 493.0
HFD2_k127_237178_3 Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00334,K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 447.0
HFD2_k127_237178_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001833 289.0
HFD2_k127_237178_5 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000000001247 131.0
HFD2_k127_237178_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000003267 120.0
HFD2_k127_237178_7 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00342 - 1.6.5.3 0.00000005758 61.0
HFD2_k127_237363_0 Beta-eliminating lyase K00639,K00652 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005951 510.0
HFD2_k127_237363_1 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000001589 227.0
HFD2_k127_237363_2 Acid phosphatase homologues - - - 0.00041 49.0
HFD2_k127_2401271_0 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000005112 168.0
HFD2_k127_2401271_1 positive regulation of acetylcholine metabolic process K06910 - - 0.000000000000000000000000000000000000000006398 156.0
HFD2_k127_254749_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004025 289.0
HFD2_k127_2630633_0 cation efflux system protein (Heavy metal efflux pump) - - - 0.0 1037.0
HFD2_k127_2630633_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 1.293e-237 749.0
HFD2_k127_2630633_2 AcrB/AcrD/AcrF family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006654 559.0
HFD2_k127_2630633_3 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004659 284.0
HFD2_k127_2630633_4 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000001412 179.0
HFD2_k127_2630633_5 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000001667 177.0
HFD2_k127_2630633_6 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000005032 168.0
HFD2_k127_2630633_7 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000005953 154.0
HFD2_k127_2630633_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000003354 122.0
HFD2_k127_2630633_9 bacterial-type flagellum-dependent cell motility - - - 0.000000000000004381 90.0
HFD2_k127_2634640_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006634 312.0
HFD2_k127_2634640_1 Thioredoxin-like - - - 0.0000000000000000000000000001806 117.0
HFD2_k127_2634640_2 PFAM YbbR family protein - - - 0.000007753 57.0
HFD2_k127_2634768_0 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 387.0
HFD2_k127_2634768_1 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 368.0
HFD2_k127_2634768_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000003988 213.0
HFD2_k127_2634768_3 Bacterial regulatory proteins, tetR family K16137 - - 0.00000000000000000000000000000000000000008391 153.0
HFD2_k127_2634768_4 DinB superfamily - - - 0.000000000000000000008781 103.0
HFD2_k127_2639087_0 Domain of unknown function (DUF3536) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006754 492.0
HFD2_k127_2639087_1 Domain of unknown function (DUF1925) K22451 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 441.0
HFD2_k127_2639087_2 Belongs to the glycosyl hydrolase 57 family K03406,K16149 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 429.0
HFD2_k127_2639087_3 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000859 206.0
HFD2_k127_2640133_0 diguanylate cyclase - - - 0.00000000000000000000000000008821 131.0
HFD2_k127_2640133_1 - - - - 0.0007044 46.0
HFD2_k127_2650933_0 lysine biosynthetic process via aminoadipic acid - - - 3.722e-237 759.0
HFD2_k127_2650933_1 AcrB/AcrD/AcrF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003252 363.0
HFD2_k127_2650933_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001184 270.0
HFD2_k127_2650933_3 Fibronectin type 3 domain - - - 0.0000000002164 74.0
HFD2_k127_2652092_0 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005706 257.0
HFD2_k127_2652092_1 DNA polymerase III alpha subunit K02337,K14162 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 0.000000000000000000000001903 107.0
HFD2_k127_2652092_2 Bacterial Ig-like domain 2 - - - 0.000005515 58.0
HFD2_k127_2655774_0 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 424.0
HFD2_k127_2655774_1 TonB-dependent Receptor Plug K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002876 401.0
HFD2_k127_2655774_2 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000001168 181.0
HFD2_k127_2655774_3 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.00000000000000000000000000005673 116.0
HFD2_k127_2655774_4 PFAM Class III cytochrome C family - - - 0.0000000000000005669 83.0
HFD2_k127_2655774_5 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000002262 76.0
HFD2_k127_2655774_6 - - - - 0.00000008327 64.0
HFD2_k127_2655774_7 YceI-like domain - - - 0.000002802 58.0
HFD2_k127_2659981_0 aminopeptidase N - - - 1.817e-282 887.0
HFD2_k127_2659981_1 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 7.099e-241 752.0
HFD2_k127_2659981_10 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000007509 190.0
HFD2_k127_2659981_11 Pathogenicity locus K07343 - - 0.00000000000000000000000001588 119.0
HFD2_k127_2659981_12 lactoylglutathione lyase activity - - - 0.0000000000000000000107 103.0
HFD2_k127_2659981_13 Protein of unknown function (DUF2914) - - - 0.0000000000000001687 88.0
HFD2_k127_2659981_14 Outer membrane efflux protein - - - 0.00000006231 66.0
HFD2_k127_2659981_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 540.0
HFD2_k127_2659981_3 HlyD family secretion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006385 505.0
HFD2_k127_2659981_4 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006011 412.0
HFD2_k127_2659981_5 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000632 377.0
HFD2_k127_2659981_6 Polysaccharide biosynthesis C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007405 377.0
HFD2_k127_2659981_7 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007849 300.0
HFD2_k127_2659981_8 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003324 273.0
HFD2_k127_2659981_9 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000000000000000254 241.0
HFD2_k127_2660162_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000009615 232.0
HFD2_k127_2660162_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000001338 217.0
HFD2_k127_2661156_0 peptidase K01415,K07386 - 3.4.24.71 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 505.0
HFD2_k127_2661156_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 455.0
HFD2_k127_2661156_2 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 417.0
HFD2_k127_2661156_3 CorA-like Mg2+ transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003645 348.0
HFD2_k127_2661156_4 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001689 270.0
HFD2_k127_2661156_5 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000007558 238.0
HFD2_k127_2661156_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000001072 124.0
HFD2_k127_2661156_7 - - - - 0.00000000000279 79.0
HFD2_k127_2661156_8 - - - - 0.000001661 60.0
HFD2_k127_2661156_9 - - - - 0.000002471 56.0
HFD2_k127_2661401_0 TonB-dependent receptor K16089 - - 0.00000000000000000000000001502 122.0
HFD2_k127_2661401_1 Transglycosylase associated protein - - - 0.00000000000000003155 83.0
HFD2_k127_2675962_0 TonB dependent receptor K02014,K16087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007386 367.0
HFD2_k127_2677255_0 SIS domain K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 368.0
HFD2_k127_2677255_1 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.00000000000000000000379 96.0
HFD2_k127_2677455_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 390.0
HFD2_k127_2677455_1 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 317.0
HFD2_k127_2677455_2 Fe-S protein K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000001992 267.0
HFD2_k127_2677455_3 - - - - 0.00000000000000000000000000001864 121.0
HFD2_k127_2677455_4 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000001214 114.0
HFD2_k127_2682090_0 denitrification pathway K02569,K15876 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007817 394.0
HFD2_k127_2682090_1 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 298.0
HFD2_k127_2682090_2 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 287.0
HFD2_k127_2682090_3 Cytochrome b/b6/petB K00412,K03888 - - 0.000000000000000000000000000000000000000000000000000000002122 216.0
HFD2_k127_2682090_4 Cytochrome c554 and c-prime K03620 - - 0.0000000000000000000000000000000000000000000000000000002066 220.0
HFD2_k127_2682090_5 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.000004297 57.0
HFD2_k127_2682090_6 PFAM Rieske 2Fe-2S K02636 - 1.10.9.1 0.0005288 51.0
HFD2_k127_2682960_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000857 561.0
HFD2_k127_2682960_1 HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 342.0
HFD2_k127_2682960_2 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 307.0
HFD2_k127_2682960_3 Belongs to the TrpC family K01609,K13498 - 4.1.1.48,5.3.1.24 0.0000000000000000000000000000000000000000000000000000000005995 211.0
HFD2_k127_2682960_4 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00002199 52.0
HFD2_k127_269155_0 Ftsk_gamma K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 620.0
HFD2_k127_269155_1 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 580.0
HFD2_k127_269155_2 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 503.0
HFD2_k127_269155_3 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 355.0
HFD2_k127_269155_4 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000003442 134.0
HFD2_k127_269155_5 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000003617 132.0
HFD2_k127_269155_6 Uncharacterised protein family UPF0102 K07460 - - 0.0000000000000000000000000001029 119.0
HFD2_k127_269155_7 2-phosphosulpholactate phosphatase - - - 0.000000000000000000001981 104.0
HFD2_k127_269155_8 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000001576 74.0
HFD2_k127_2698600_0 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008828 383.0
HFD2_k127_2698600_1 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 373.0
HFD2_k127_2698600_2 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 309.0
HFD2_k127_2698600_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001943 248.0
HFD2_k127_2698600_4 DinB superfamily - - - 0.0002646 46.0
HFD2_k127_2698705_0 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.0000000000000000000000000000000000000000000000000000000000006844 228.0
HFD2_k127_2698705_1 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000005925 176.0
HFD2_k127_2698705_2 Lipopolysaccharide-assembly - - - 0.000000000000000000000000000000000000001338 154.0
HFD2_k127_2698705_3 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000001914 153.0
HFD2_k127_2698705_4 - - - - 0.00000002517 66.0
HFD2_k127_2699741_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 4.603e-225 726.0
HFD2_k127_2699741_2 - - - - 0.000000006457 64.0
HFD2_k127_2701227_0 DALR_2 K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 533.0
HFD2_k127_2701227_1 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 405.0
HFD2_k127_2701227_2 PspA/IM30 family K03969 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001768 279.0
HFD2_k127_2701227_3 mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000101 218.0
HFD2_k127_2701227_4 permease - - - 0.0000000000000000000000000000000000000000000000000000001397 216.0
HFD2_k127_2701227_5 Yip1 domain - - - 0.0000000000000000000000000000000000000007293 152.0
HFD2_k127_2701227_6 ATPases associated with a variety of cellular activities K01990,K19340 - - 0.0000000000000000000003824 111.0
HFD2_k127_2710534_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1257.0
HFD2_k127_2710534_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 387.0
HFD2_k127_2710534_2 RadC-like JAB domain K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007038 246.0
HFD2_k127_2710534_3 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000005596 151.0
HFD2_k127_2710534_4 Outer membrane lipoprotein K05807 - - 0.00000000000000000000000000000001154 138.0
HFD2_k127_2713930_0 serine-type peptidase activity K08676 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 8.59e-197 628.0
HFD2_k127_2713930_1 transcriptional activator domain - - - 0.00000000000000000000000000001405 137.0
HFD2_k127_2713972_0 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 392.0
HFD2_k127_2713972_1 Poly (ADP-ribose) glycohydrolase (PARG) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001612 241.0
HFD2_k127_2713972_2 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000005361 140.0
HFD2_k127_2715451_0 Aminotransferase class I and II K00812,K10907 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000001059 250.0
HFD2_k127_2715451_1 Belongs to the peptidase M24B family - - - 0.00000000000006565 72.0
HFD2_k127_2715451_2 23S rRNA-intervening sequence protein - - - 0.0000000000001346 75.0
HFD2_k127_271972_0 Large extracellular alpha-helical protein K06894 - - 0.0 1751.0
HFD2_k127_2727642_0 Fimbrial assembly protein (PilN) - - - 0.00000000000000000000000000000000002374 143.0
HFD2_k127_2727642_1 Pilus assembly protein, PilO K02664 - - 0.000000000000000000000000002958 119.0
HFD2_k127_2727642_2 - - - - 0.00000000000000000000001833 105.0
HFD2_k127_2733098_0 VWA domain containing CoxE-like protein K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003586 378.0
HFD2_k127_2733098_1 Pfam Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000003192 207.0
HFD2_k127_2733098_2 XdhC and CoxI family K07402 - - 0.000000000000000000000000000000000000000001262 170.0
HFD2_k127_2733098_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000005524 160.0
HFD2_k127_2733098_4 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000001181 135.0
HFD2_k127_2733098_5 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000003319 74.0
HFD2_k127_2733098_6 von Willebrand factor type A domain K07114 - - 0.0000001507 63.0
HFD2_k127_2734727_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009374 380.0
HFD2_k127_2734727_1 Domain of unknown function(DUF2779) - - - 0.0000000000000000000000000000000000000000001594 165.0
HFD2_k127_2734727_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.000000000000000000000000000000001528 150.0
HFD2_k127_2734727_3 PFAM outer membrane efflux protein - - - 0.000000000000000000000000000000005228 145.0
HFD2_k127_2734727_4 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000001082 99.0
HFD2_k127_2738914_0 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 374.0
HFD2_k127_2738914_1 amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 385.0
HFD2_k127_2738914_2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 321.0
HFD2_k127_2738914_3 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.0000000000000000000000000000000000000000000000000000000004009 216.0
HFD2_k127_2738914_4 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000006488 168.0
HFD2_k127_2738914_5 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000007116 180.0
HFD2_k127_2738914_6 Peptidase M16 - - - 0.000000005637 66.0
HFD2_k127_2743024_0 PFAM peptidase M18 aminopeptidase I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008815 426.0
HFD2_k127_2743024_1 oligopeptide transporter, OPT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 317.0
HFD2_k127_2743024_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000006284 235.0
HFD2_k127_2743024_3 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000001052 205.0
HFD2_k127_2747131_0 Aminotransferase class-III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 565.0
HFD2_k127_2747131_1 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000164 227.0
HFD2_k127_2747131_2 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000003011 215.0
HFD2_k127_2751239_0 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003063 407.0
HFD2_k127_2751239_1 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004294 280.0
HFD2_k127_2751239_2 Belongs to the short-chain dehydrogenases reductases (SDR) family K05886 - 1.1.1.276 0.000000000000000000000000000000000000000000000000000000000000000000000000005343 276.0
HFD2_k127_27548_0 Competence-damaged protein K03742 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008778 419.0
HFD2_k127_27548_1 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000000000000000000000000000000001027 143.0
HFD2_k127_27548_2 Serine aminopeptidase, S33 - - - 0.00000000000003115 76.0
HFD2_k127_2776126_0 WD40-like Beta Propeller Repeat K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006367 314.0
HFD2_k127_2776126_1 MotA/TolQ/ExbB proton channel family K03562 - - 0.00000000000000000000000000000000000000000000000000000004664 205.0
HFD2_k127_2776126_2 OmpA family K03640 - - 0.00000000000000000000000000000000000000000786 162.0
HFD2_k127_2776126_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000008966 161.0
HFD2_k127_2776126_4 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.000000000000000000000000000000000000004636 149.0
HFD2_k127_2776126_5 Outer membrane lipoprotein - - - 0.0000000000000000000000000000000000002547 150.0
HFD2_k127_2776126_6 TonB C terminal K03832 - - 0.00000000000000000000003943 115.0
HFD2_k127_2776126_7 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0001812 44.0
HFD2_k127_2779434_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007906 274.0
HFD2_k127_2779434_1 Rhodanese Homology Domain K01069,K03797 - 3.1.2.6,3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000004267 255.0
HFD2_k127_2779434_2 Putative tRNA binding domain K06878 - - 0.00000000000000000000000000000000000000001195 158.0
HFD2_k127_2779434_3 - - - - 0.000000000000000008269 93.0
HFD2_k127_27846_0 response to heat K03695,K03696,K03697,K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007045 332.0
HFD2_k127_27846_1 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001435 276.0
HFD2_k127_27846_2 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000000000002499 230.0
HFD2_k127_27846_3 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.00000000000000000000000000000000000000000000002205 192.0
HFD2_k127_27846_4 Uncharacterized conserved protein (COG2071) K09166 - - 0.00000000000000000000000000000000001652 153.0
HFD2_k127_27846_5 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000005552 94.0
HFD2_k127_2790355_0 ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 319.0
HFD2_k127_2790355_1 Glycosyltransferase family 87 - - - 0.000000000000000000005329 106.0
HFD2_k127_2790355_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000002121 87.0
HFD2_k127_2792144_0 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 1.966e-205 646.0
HFD2_k127_2792144_1 major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 493.0
HFD2_k127_2792144_2 Zincin-like metallopeptidase - - - 0.0000000000000003017 88.0
HFD2_k127_2792144_3 Domain of unknown function (DUF4404) - - - 0.0000002162 63.0
HFD2_k127_2792624_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004761 581.0
HFD2_k127_2792624_1 4-vinyl reductase, 4VR - - - 0.0000000265 61.0
HFD2_k127_2801956_0 LVIVD repeat - - - 1.471e-220 708.0
HFD2_k127_2801956_1 Domain of unknown function (DUF305) - - - 0.0000000000000000000000000000000000000000000000000000000000000004866 225.0
HFD2_k127_2801956_2 LVIVD repeat - - - 0.0000000002287 63.0
HFD2_k127_2810819_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004082 578.0
HFD2_k127_2810819_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000001378 147.0
HFD2_k127_2846543_0 COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase K05350 - 3.2.1.21 2.314e-197 627.0
HFD2_k127_2846543_1 ABC transporter K10112,K11072,K17324 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005346 353.0
HFD2_k127_2846543_2 COG3459 Cellobiose phosphorylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006039 270.0
HFD2_k127_2858375_0 Glycosyl hydrolase family 9 K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 415.0
HFD2_k127_2872728_0 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 481.0
HFD2_k127_2872728_1 Dihydrodipicolinate synthetase family - - - 0.0000000000000000000000000000000001777 151.0
HFD2_k127_2873092_0 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 599.0
HFD2_k127_2873092_1 tRNA processing K06864 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002657 261.0
HFD2_k127_2873092_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531 3.1.4.58 0.00000000000000000000000000003048 129.0
HFD2_k127_2873092_3 - - - - 0.00000000000000005916 95.0
HFD2_k127_2873092_4 Aldehyde dehydrogenase family K22187 - - 0.0000000000000001084 79.0
HFD2_k127_2873092_5 helix_turn_helix ASNC type - - - 0.000000000003767 68.0
HFD2_k127_2884979_0 acyl-CoA transferases carnitine dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003957 556.0
HFD2_k127_2884979_1 Thymidine kinase K00857 - 2.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004454 291.0
HFD2_k127_2884979_2 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000000000004325 204.0
HFD2_k127_2884979_3 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000003576 102.0
HFD2_k127_2884979_4 - - - - 0.00000000000001022 80.0
HFD2_k127_2884979_5 aminopeptidase activity K01266 - 3.4.11.19 0.00001148 48.0
HFD2_k127_2884979_6 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0033554,GO:0033592,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112 3.6.4.13 0.00005036 55.0
HFD2_k127_2891131_0 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005827 278.0
HFD2_k127_2891131_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000652 188.0
HFD2_k127_2891131_2 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000003837 167.0
HFD2_k127_289312_0 PFAM Uncharacterised ACR, YagE family COG1723 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 385.0
HFD2_k127_289312_1 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 378.0
HFD2_k127_289312_2 DinB superfamily - - - 0.000000000000000000000000000000001842 137.0
HFD2_k127_289312_3 PFAM Pentapeptide repeats (8 copies) - - - 0.00000000000004909 79.0
HFD2_k127_2895229_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.461e-280 877.0
HFD2_k127_2895229_1 Aromatic amino acid lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 544.0
HFD2_k127_2895229_2 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007189 469.0
HFD2_k127_2895229_3 Amidohydrolase family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009016 333.0
HFD2_k127_2895229_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.000000000000000000000000000000000000000000000001152 201.0
HFD2_k127_2895229_5 OmpA family K03640 - - 0.0000000000000000000000000000000000000000009977 158.0
HFD2_k127_2895229_6 Outer membrane lipoprotein - - - 0.00000000000000000000000000000000000005367 152.0
HFD2_k127_2909799_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 5.762e-236 753.0
HFD2_k127_2909799_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000003791 277.0
HFD2_k127_2909799_2 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000008314 217.0
HFD2_k127_2909799_3 - - - - 0.00000000000000000000000000000003925 145.0
HFD2_k127_2909799_4 - - - - 0.0000000000000000000000000002188 115.0
HFD2_k127_2909799_5 Hsp20/alpha crystallin family K13993 - - 0.00000003565 57.0
HFD2_k127_2920876_0 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 372.0
HFD2_k127_2920876_1 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000001085 245.0
HFD2_k127_2920876_2 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000003051 254.0
HFD2_k127_2920876_3 Peptidyl-prolyl cis-trans isomerase K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000005773 211.0
HFD2_k127_2920876_4 - - - - 0.0000000000000000001799 94.0
HFD2_k127_2926471_0 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001166 291.0
HFD2_k127_2926471_1 Endonuclease related to archaeal Holliday junction resolvase - - - 0.00000000000000000000000000002108 123.0
HFD2_k127_2926471_2 TonB-dependent receptor - - - 0.0000000000005329 82.0
HFD2_k127_2926471_3 EamA-like transporter family - - - 0.0000005213 61.0
HFD2_k127_2932917_0 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009645 391.0
HFD2_k127_2932917_1 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000000000008585 187.0
HFD2_k127_2932917_2 Glycosyl transferase family 2 K08301 - - 0.000000000000000000000000000000000000000000004325 182.0
HFD2_k127_2932917_3 FAD dependent oxidoreductase K03153 - 1.4.3.19 0.0000000000000000000000000000006254 135.0
HFD2_k127_2932917_4 - - - - 0.0000006023 54.0
HFD2_k127_2948924_0 Alkaline phosphatase K01113 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 606.0
HFD2_k127_2948924_1 - - - - 0.0002798 45.0
HFD2_k127_2987363_0 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 3.54e-216 679.0
HFD2_k127_2987363_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 599.0
HFD2_k127_2987363_2 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 348.0
HFD2_k127_2987363_3 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 295.0
HFD2_k127_2987363_4 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007268 252.0
HFD2_k127_2987363_5 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000001483 241.0
HFD2_k127_2987363_6 DinB family - - - 0.000000000000000000000000000000000009091 143.0
HFD2_k127_2987363_7 30S ribosomal protein Thx K19033 - - 0.0008753 49.0
HFD2_k127_3030725_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000326 257.0
HFD2_k127_3036921_0 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 358.0
HFD2_k127_3055192_0 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000001338 184.0
HFD2_k127_3055192_1 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000004893 171.0
HFD2_k127_3055192_2 Helix-turn-helix domain - - - 0.000000000000000000000003305 113.0
HFD2_k127_3055192_3 Outer membrane protein beta-barrel domain - - - 0.0000000000004451 78.0
HFD2_k127_3111034_0 Dehydrogenase - - - 6.263e-207 653.0
HFD2_k127_3111034_1 DinB family - - - 0.0000000000000000000000000000000000000000000000000000003165 214.0
HFD2_k127_3111034_2 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.000000000000000000000001068 115.0
HFD2_k127_3154721_0 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006806 579.0
HFD2_k127_3154721_1 Bacterial sugar transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000003035 239.0
HFD2_k127_3154721_2 PFAM formyl transferase domain protein - - - 0.000000000000000000000000000000004451 135.0
HFD2_k127_3267496_0 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 391.0
HFD2_k127_3267496_1 Enoyl-(Acyl carrier protein) reductase K00059,K07535 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000005179 205.0
HFD2_k127_3267496_2 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.0000000000000000000000000000000000000000002539 169.0
HFD2_k127_3267496_3 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 0.000000000000000000008821 96.0
HFD2_k127_3278799_0 peptidase S45, penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000002223 189.0
HFD2_k127_3278799_1 Glycerate kinase family K00865 - 2.7.1.165 0.0000000000000000000000000142 115.0
HFD2_k127_32806_0 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 374.0
HFD2_k127_32806_1 ABC nitrate sulphonate bicarbonate family transporter, ATPase subunit K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000558 351.0
HFD2_k127_32806_2 Uncharacterised conserved protein (DUF2156) K14205 - 2.3.2.3 0.000000000000000000000000000000000000004681 161.0
HFD2_k127_32806_3 SNARE associated Golgi protein - - - 0.000000000000002145 89.0
HFD2_k127_3331984_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 406.0
HFD2_k127_3331984_1 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000004689 179.0
HFD2_k127_3331984_2 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000001226 162.0
HFD2_k127_3341435_0 Phosphoesterase family K21302 - 3.1.3.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 304.0
HFD2_k127_3341435_1 Domain of unknown function (DUF5117) - - - 0.000000000000000000000000000000000000000000000000000000000000000001078 237.0
HFD2_k127_3341435_2 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000005482 191.0
HFD2_k127_33587_0 Belongs to the aldehyde dehydrogenase family K00128,K00146 - 1.2.1.3,1.2.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 535.0
HFD2_k127_33587_1 Belongs to the enoyl-CoA hydratase isomerase family K01692,K08299,K15866 GO:0003674,GO:0003824,GO:0004300,GO:0005488,GO:0005515,GO:0006082,GO:0006575,GO:0006577,GO:0006579,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006805,GO:0006807,GO:0008150,GO:0008152,GO:0008809,GO:0009056,GO:0009062,GO:0009404,GO:0009407,GO:0009410,GO:0009437,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019439,GO:0019748,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0034641,GO:0042178,GO:0042219,GO:0042221,GO:0042413,GO:0042445,GO:0042447,GO:0042537,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097164,GO:0098754,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 4.2.1.149,4.2.1.17,5.3.3.18 0.0000000000000000000000000000000000000000002815 168.0
HFD2_k127_33587_2 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000006774 129.0
HFD2_k127_3509984_0 7TM receptor with intracellular HD hydrolase K07037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 509.0
HFD2_k127_3509984_1 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009881 422.0
HFD2_k127_3509984_2 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 326.0
HFD2_k127_3509984_3 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000004869 109.0
HFD2_k127_3521943_0 DNA ligase (ATP) activity K01971 - 6.5.1.1 6.984e-308 980.0
HFD2_k127_3521943_1 Belongs to the peptidase S1B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001923 548.0
HFD2_k127_3521943_2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008849 383.0
HFD2_k127_3521943_3 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 342.0
HFD2_k127_3521943_4 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 297.0
HFD2_k127_3521943_5 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004401 261.0
HFD2_k127_3521943_6 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000004461 232.0
HFD2_k127_3521943_7 EVE domain - - - 0.0000000000000000000000000000000000000000007455 162.0
HFD2_k127_3521943_8 PFAM Rhomboid family - - - 0.0000000000000000000000000009918 123.0
HFD2_k127_3523480_0 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 8.823e-255 807.0
HFD2_k127_3523480_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 585.0
HFD2_k127_3523480_2 peptidase S9B dipeptidylpeptidase IV domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 353.0
HFD2_k127_3524386_0 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004296 487.0
HFD2_k127_3524386_1 POT family K03305 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 458.0
HFD2_k127_3524386_2 Family of unknown function (DUF1028) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006057 302.0
HFD2_k127_3524386_3 - - - - 0.0000000000000000002481 95.0
HFD2_k127_3524386_4 Regulatory protein, FmdB family - - - 0.000000000001315 69.0
HFD2_k127_3527894_0 Protein kinase domain K08884 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 349.0
HFD2_k127_3527894_1 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 314.0
HFD2_k127_3527894_2 Forkhead associated domain - - - 0.00003964 56.0
HFD2_k127_3527894_3 Ami_3 K01448 - 3.5.1.28 0.0005288 51.0
HFD2_k127_3531429_0 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000002786 138.0
HFD2_k127_3531429_1 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000293 132.0
HFD2_k127_3531429_2 1,4-alpha-glucan branching enzyme activity K00700 - 2.4.1.18 0.00000000000000008693 93.0
HFD2_k127_3531429_3 Tetratricopeptide repeat - - - 0.000000004619 57.0
HFD2_k127_3531429_4 - - - - 0.00000001476 64.0
HFD2_k127_3531457_0 X-Pro dipeptidyl-peptidase domain protein K06978 - - 5.025e-258 841.0
HFD2_k127_3531457_1 FtsX-like permease family K02004 - - 2.872e-198 654.0
HFD2_k127_3531457_2 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006404 483.0
HFD2_k127_3531457_3 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000003245 227.0
HFD2_k127_3531457_4 - - - - 0.000000000000000000000000000000000000000000000000000000000003033 218.0
HFD2_k127_3531457_5 heme binding - - - 0.00000000000000000000000000000000000000000000000007072 189.0
HFD2_k127_3531457_6 Fibronectin type 3 domain - - - 0.00000000000000001074 95.0
HFD2_k127_3531457_7 PFAM regulatory protein, ArsR - - - 0.00000000000000001829 91.0
HFD2_k127_3536723_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138,K18307 - - 4.919e-237 758.0
HFD2_k127_3536723_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K18306 - - 0.0000000000000000000000000000000000003461 161.0
HFD2_k127_3536723_2 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000586 159.0
HFD2_k127_3537155_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 3.822e-265 827.0
HFD2_k127_3537155_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 4.861e-234 751.0
HFD2_k127_3537155_2 N-Acetylmuramoyl-L-alanine amidase K01187 - 3.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 561.0
HFD2_k127_3537155_3 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000001127 230.0
HFD2_k127_3537155_4 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000002781 136.0
HFD2_k127_3537155_5 - - - - 0.0000000000008535 73.0
HFD2_k127_3538129_0 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 8.434e-240 748.0
HFD2_k127_3538129_1 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006213 306.0
HFD2_k127_3538129_2 Thioesterase-like superfamily - - - 0.000000000000000000000000000000000001782 142.0
HFD2_k127_3556103_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 593.0
HFD2_k127_3557746_0 DNA restriction-modification system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000539 255.0
HFD2_k127_3557746_1 SNF2 family N-terminal domain - - - 0.0000000000000000000437 101.0
HFD2_k127_3561689_0 Peptidase S46 - GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009986,GO:0009987,GO:0016020,GO:0016049,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030154,GO:0030312,GO:0030313,GO:0031975,GO:0032502,GO:0033218,GO:0034641,GO:0040007,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048869,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007554 558.0
HFD2_k127_3563338_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 437.0
HFD2_k127_3563338_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 432.0
HFD2_k127_3563338_2 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 305.0
HFD2_k127_3563338_3 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000003198 244.0
HFD2_k127_3563338_4 Belongs to the SEDS family K03588 - - 0.0000000000000000000000000000000000000000007648 174.0
HFD2_k127_3566607_0 Elongation factor G, domain IV K02355 - - 2.032e-269 846.0
HFD2_k127_3566607_1 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 625.0
HFD2_k127_3566607_2 of the major facilitator superfamily K08151 - - 0.000000000000000000000000000000000000000000000000000000000000000009175 237.0
HFD2_k127_3566607_3 gluconolactonase activity K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000005483 223.0
HFD2_k127_3573886_0 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.00000000000000000000000000000000000000000000000000000001682 199.0
HFD2_k127_3573886_1 Phage integrase, N-terminal SAM-like domain K04763 - - 0.000000000000000000000000000000000000000000000000004509 196.0
HFD2_k127_3573886_2 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.0000000000000000000000000000000000000000000001538 178.0
HFD2_k127_3573886_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000206 144.0
HFD2_k127_3573886_4 SNARE associated Golgi protein - - - 0.0000000006553 71.0
HFD2_k127_3594403_0 - - - - 0.0000000000000000000000000007657 126.0
HFD2_k127_3594403_1 type II secretion system protein E K02243,K02652 - - 0.000000000003393 74.0
HFD2_k127_3613020_0 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 309.0
HFD2_k127_3613020_1 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006159 280.0
HFD2_k127_3613020_2 glyoxalase III activity - - - 0.00000000000000000000000000000000000000000000000000000000000003378 225.0
HFD2_k127_3613020_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000006734 160.0
HFD2_k127_3613020_4 Adenylyl- / guanylyl cyclase, catalytic domain K01768,K01769 - 4.6.1.1,4.6.1.2 0.00000000000000000000000000007695 121.0
HFD2_k127_3613020_5 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000006818 69.0
HFD2_k127_3623361_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 517.0
HFD2_k127_3623361_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 416.0
HFD2_k127_3623361_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 372.0
HFD2_k127_3623361_3 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000004465 203.0
HFD2_k127_3635971_0 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide - - - 8.35e-232 747.0
HFD2_k127_3635971_1 Nucleoside H+ symporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 560.0
HFD2_k127_3635971_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007703 300.0
HFD2_k127_3635971_3 Bax inhibitor 1 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001653 248.0
HFD2_k127_3635971_4 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002286 246.0
HFD2_k127_3635971_5 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000005973 202.0
HFD2_k127_3635971_6 acetyltransferase - - - 0.00000000000000000000000000000000000000002658 166.0
HFD2_k127_3635971_7 Protein of Unknown function (DUF2784) - - - 0.0000000000000000000000000000000001921 147.0
HFD2_k127_3635971_8 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.0000000000000004703 91.0
HFD2_k127_3635971_9 PFAM RNA-binding S4 K04762 - - 0.00001476 48.0
HFD2_k127_3654304_0 PFAM cytochrome bd ubiquinol oxidase subunit II K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000001306 226.0
HFD2_k127_3654304_1 YGGT family K02221 - - 0.0000000000000000000000000000004136 130.0
HFD2_k127_3654304_2 Belongs to the UPF0235 family K09131 - - 0.0000000000000000008123 89.0
HFD2_k127_3663143_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 366.0
HFD2_k127_3663143_1 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000003969 243.0
HFD2_k127_3663143_2 CO dehydrogenase flavoprotein C-terminal domain K13479 - 1.17.1.4 0.0000000000000000000000000000000000000000000001127 179.0
HFD2_k127_3663143_3 [2Fe-2S] binding domain K03518,K13483 - 1.2.5.3 0.0000000000000000000000000000000000000001391 155.0
HFD2_k127_367501_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000003861 144.0
HFD2_k127_367501_1 Septum formation initiator K05589 - - 0.00000001734 63.0
HFD2_k127_367501_2 PEGA domain - - - 0.0000187 56.0
HFD2_k127_3676442_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 329.0
HFD2_k127_3676442_1 Appr-1'-p processing enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000003116 230.0
HFD2_k127_3676442_2 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000005269 210.0
HFD2_k127_3676442_3 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000008965 194.0
HFD2_k127_3676442_4 Protein kinase domain K12132 - 2.7.11.1 0.00000000000004881 75.0
HFD2_k127_3682749_0 Amidinotransferase K01482 - 3.5.3.18 0.0000000000000000000000000000000000000000000000002908 179.0
HFD2_k127_3686494_0 cellulose binding - - - 1.02e-208 681.0
HFD2_k127_3686494_1 CarboxypepD_reg-like domain K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 404.0
HFD2_k127_3686494_10 - - - - 0.0005894 52.0
HFD2_k127_3686494_2 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008652 374.0
HFD2_k127_3686494_3 PFAM magnesium chelatase ChlI subunit K07391 - - 0.0000000000000000000000000000000000000000000000000000000000001385 217.0
HFD2_k127_3686494_4 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000001083 207.0
HFD2_k127_3686494_5 phosphorelay signal transduction system K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000006601 183.0
HFD2_k127_3686494_6 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000001235 183.0
HFD2_k127_3686494_7 Carboxypeptidase regulatory-like domain K02014 - - 0.0000000000000000000001198 108.0
HFD2_k127_3686494_8 PEGA domain - - - 0.000001854 58.0
HFD2_k127_3686494_9 - - - - 0.00007083 53.0
HFD2_k127_3687002_0 Serine hydrolase (FSH1) - - - 6.117e-194 614.0
HFD2_k127_3687002_1 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 383.0
HFD2_k127_3687002_2 Major facilitator Superfamily K00943,K08217,K18833 - 2.7.4.9 0.00000000000000000000000000000000000000000000001227 174.0
HFD2_k127_3687002_3 Squalene phytoene synthase K00801 - 2.5.1.21 0.0000000003849 72.0
HFD2_k127_3687337_0 Drug exporters of the RND superfamily K06994,K07003,K20466,K20470 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009273,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0040007,GO:0042546,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071766,GO:0071840,GO:0071944,GO:1901264 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 582.0
HFD2_k127_3687337_1 PFAM GH3 auxin-responsive promoter - - - 0.000000000000000000000000000000000000000000000000000003914 210.0
HFD2_k127_3687337_2 Formate/nitrite transporter K06212,K21993 - - 0.0000000000000000000000000000000000000000000000000006588 196.0
HFD2_k127_3687337_3 Formate/nitrite transporter K06212,K21993 - - 0.0000000000000000000000000000000000000000000000004971 185.0
HFD2_k127_3687337_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000728 99.0
HFD2_k127_3687337_5 Psort location Cytoplasmic, score 9.97 K00661 - 2.3.1.79 0.0002404 51.0
HFD2_k127_3700166_0 aminopeptidase K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 365.0
HFD2_k127_3700166_1 - - - - 0.000000000000000000000000000000000000003942 154.0
HFD2_k127_3702673_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007561 465.0
HFD2_k127_3702673_1 DoxX K15977 - - 0.00000001141 66.0
HFD2_k127_3702673_2 Cyclic nucleotide-monophosphate binding domain - - - 0.00007463 45.0
HFD2_k127_3702673_3 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.0002601 51.0
HFD2_k127_3707940_0 Ferrous iron transport protein B K04759 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 541.0
HFD2_k127_3707940_1 - - - - 0.000000000000000000000000000000001705 149.0
HFD2_k127_3707940_2 FeoA K04758 - - 0.0000000000000000001475 90.0
HFD2_k127_3709273_0 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate - - - 0.00000000000000000000000000000000000004092 151.0
HFD2_k127_3709273_1 SNF2 family N-terminal domain - - - 0.0000000000000000000001658 113.0
HFD2_k127_3709273_2 Hydrolyzes pyrophosphate formed during P-Ser-HPr dephosphorylation by HPrK P. Might play a role in controlling the intracellular pyrophosphate pool K06019 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.1 0.000000000000000003357 87.0
HFD2_k127_3711142_0 Belongs to the bacterial solute-binding protein 9 family K02077,K09815,K09818 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 324.0
HFD2_k127_3711142_1 ABC 3 transport family K02075,K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003929 247.0
HFD2_k127_3711142_2 Tfp pilus assembly protein FimV K00694 - 2.4.1.12 0.0000000000000000000000000000000000000000000000000001863 202.0
HFD2_k127_3711142_3 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000002692 162.0
HFD2_k127_3711142_4 malic enzyme K00027,K00029 - 1.1.1.38,1.1.1.40 0.0000002493 52.0
HFD2_k127_3711142_5 Zinc-dependent metalloprotease - - - 0.000791 51.0
HFD2_k127_3721243_0 Dipeptidyl peptidase IV (DPP IV) K01278 - 3.4.14.5 1.15e-265 835.0
HFD2_k127_3721243_1 Amino acid permease K03294 - - 0.00000000000000000000003533 109.0
HFD2_k127_3748534_0 epimerase dehydratase K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000008302 204.0
HFD2_k127_3748534_1 Domain of unknown function (DUF4382) - - - 0.000000000000004821 87.0
HFD2_k127_3761876_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 458.0
HFD2_k127_3761876_1 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004436 267.0
HFD2_k127_3761876_2 ABC transporter, ATP-binding protein K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001236 257.0
HFD2_k127_3761876_3 MlaD protein K02067 - - 0.00000000000000000000000000005152 123.0
HFD2_k127_3761876_4 Belongs to the 'phage' integrase family - - - 0.000002684 51.0
HFD2_k127_3762840_0 protein import - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009366 527.0
HFD2_k127_3762840_1 peptidyl-tyrosine sulfation K13992 - - 0.0000000000000000000000000000000000000000000000000001974 194.0
HFD2_k127_3762840_2 Carbohydrate family 9 binding domain-like - - - 0.0000000000000000000000000000000000000000001671 166.0
HFD2_k127_3763493_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1109.0
HFD2_k127_3763493_1 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000002 286.0
HFD2_k127_3763493_2 EamA-like transporter family - - - 0.000000000000000000000000000004993 135.0
HFD2_k127_3763493_3 integral membrane protein K07027 - - 0.0000000000000000000002998 110.0
HFD2_k127_3763493_4 FHA modulated ABC efflux pump with fused ATPase and integral membrane subunits - - - 0.000000000000000004235 98.0
HFD2_k127_3767353_0 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000006341 274.0
HFD2_k127_3767353_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000004295 207.0
HFD2_k127_3767353_2 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000001653 81.0
HFD2_k127_3771307_0 Helicase K03724 - - 9.882e-316 984.0
HFD2_k127_3788724_0 Aldehyde dehydrogenase family K22187 - - 2.387e-263 817.0
HFD2_k127_3788724_1 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000002407 180.0
HFD2_k127_3788724_2 - - - - 0.00000000000000006846 91.0
HFD2_k127_3799898_0 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01761 - 4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000315 584.0
HFD2_k127_3799898_1 Oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 547.0
HFD2_k127_3799898_2 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 385.0
HFD2_k127_3799898_3 redox protein regulator of disulfide bond formation K04063 - - 0.000000000000000000000000000000002998 134.0
HFD2_k127_3799898_4 Glyoxalase-like domain - - - 0.0000005857 58.0
HFD2_k127_3816456_0 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 452.0
HFD2_k127_3816456_1 - - - - 0.0000000000000000000000000000000000000002138 154.0
HFD2_k127_3816456_2 hydroperoxide reductase activity K01607 - 4.1.1.44 0.0004362 43.0
HFD2_k127_3817375_0 heme-copper terminal oxidase activity K02274 - 1.9.3.1 2.498e-205 654.0
HFD2_k127_3817375_1 Methyl-viologen-reducing hydrogenase, delta subunit K02572,K02573,K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003662 274.0
HFD2_k127_3817375_2 cytochrome c oxidase (Subunit II) - - - 0.0000000000000000000000000000000000000000000000000000000003339 207.0
HFD2_k127_3817375_3 Transcriptional regulator - - - 0.00000000000000000000000008615 111.0
HFD2_k127_3845718_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 450.0
HFD2_k127_3845718_1 pyrroloquinoline quinone binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 417.0
HFD2_k127_3845718_2 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004159 379.0
HFD2_k127_3845718_3 alginic acid biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000008533 218.0
HFD2_k127_3845718_4 alginic acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000001938 209.0
HFD2_k127_3845718_5 Protein of unknown function (DUF1565) - - - 0.00000000000000000005664 106.0
HFD2_k127_3845718_6 VanZ like family - - - 0.00009613 54.0
HFD2_k127_3876873_0 ATPase with chaperone activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 405.0
HFD2_k127_3876873_1 type II secretion system protein K12511 - - 0.0000000000000000000000000000000000000000000000000000005675 205.0
HFD2_k127_3876873_2 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.00000000000000000000000000000000000000000000000000007751 188.0
HFD2_k127_3876873_3 positive regulation of proteasomal protein catabolic process - - - 0.0000000000000000000000000001343 133.0
HFD2_k127_3876873_4 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000008451 100.0
HFD2_k127_3876873_5 23S rRNA-intervening sequence protein - - - 0.00000000000000306 80.0
HFD2_k127_3876873_6 Type II secretion system K12510 - - 0.00000000001881 66.0
HFD2_k127_3876873_7 - - - - 0.00000000002884 72.0
HFD2_k127_3886923_0 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006852 421.0
HFD2_k127_3886923_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 430.0
HFD2_k127_3886923_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006722 288.0
HFD2_k127_3886923_3 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003295 288.0
HFD2_k127_3886923_4 phosphorelay signal transduction system K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000004944 279.0
HFD2_k127_3886923_5 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000001419 253.0
HFD2_k127_3886923_6 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000005546 191.0
HFD2_k127_3886923_7 PFAM Biotin lipoate A B protein ligase K03800 - 6.3.1.20 0.00000000000000000000000000002238 133.0
HFD2_k127_3893191_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007499 350.0
HFD2_k127_3893191_1 Oxygen tolerance - - - 0.0000000000000000000000000000000000000325 165.0
HFD2_k127_3922392_0 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 306.0
HFD2_k127_3922392_1 PFAM thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 290.0
HFD2_k127_3922392_2 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00177 - 1.2.7.3 0.0000000000000000000000000001278 130.0
HFD2_k127_3922392_3 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000001198 109.0
HFD2_k127_3922392_4 Protein of unknown function (DUF2934) - - - 0.00000000000000000005105 98.0
HFD2_k127_3952803_0 Transposase DDE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 479.0
HFD2_k127_3952803_1 - - - - 0.000000000000000000000000000000000000000000000000000005291 197.0
HFD2_k127_3952803_2 - - - - 0.0000000000000000000000001835 111.0
HFD2_k127_3952803_3 Acetyltransferase (GNAT) domain - - - 0.000000000000001328 78.0
HFD2_k127_3971966_0 Protein of unknown function (DUF1194) K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002492 340.0
HFD2_k127_3971966_1 von Willebrand factor type A domain K07114 - - 0.000000000000000000000000000000000000000000000000000000002326 227.0
HFD2_k127_4014700_0 alpha,alpha-trehalase activity K01194,K03931 GO:0003674,GO:0003824,GO:0004553,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015926,GO:0016787,GO:0016798,GO:0033554,GO:0050896,GO:0051716 3.2.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 357.0
HFD2_k127_4015539_0 Protein involved in DNA binding, transposase activity and DNA transposition - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 517.0
HFD2_k127_4015539_1 Involved in chromosome partitioning - - - 0.000000000000000000000000000000000000000000000001886 187.0
HFD2_k127_4101119_0 lysine biosynthetic process via aminoadipic acid - - - 1.714e-240 777.0
HFD2_k127_4101119_1 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 528.0
HFD2_k127_4101119_2 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000007789 268.0
HFD2_k127_4101119_3 Domain of unknown function (DUF3471) K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000002519 231.0
HFD2_k127_4101119_4 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000000001813 209.0
HFD2_k127_4101119_5 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000005533 152.0
HFD2_k127_4141209_0 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000000000000005024 226.0
HFD2_k127_4141209_1 PFAM Cold-shock protein, DNA-binding K03704 - - 0.00000000000000000000000000133 113.0
HFD2_k127_4179994_0 PFAM Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003946 300.0
HFD2_k127_4179994_1 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000001096 238.0
HFD2_k127_4179994_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000009514 214.0
HFD2_k127_4179994_3 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.000000000000000000003582 94.0
HFD2_k127_435333_0 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000008968 229.0
HFD2_k127_435333_1 DNA polymerase alpha chain like domain K02347 - - 0.00000000000000000000000000000000000000000000000008356 187.0
HFD2_k127_435333_2 Bacterial transcription activator, effector binding domain - - - 0.0000000000001032 72.0
HFD2_k127_4395182_0 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 0.00000000000000000000000000000000000000000000000000000000000000002394 230.0
HFD2_k127_4395182_1 domain, Protein K13735 - - 0.000000001819 70.0
HFD2_k127_4396164_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 322.0
HFD2_k127_4396164_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000009276 56.0
HFD2_k127_4396164_2 - - - - 0.00005834 50.0
HFD2_k127_4397051_0 Peptidase dimerisation domain K01439,K13049 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007868 503.0
HFD2_k127_4397051_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 338.0
HFD2_k127_4397051_2 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000005722 106.0
HFD2_k127_4397051_3 Protein kinase domain K12132 - 2.7.11.1 0.000000000000676 72.0
HFD2_k127_4402298_0 RDD family K06384 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009962 330.0
HFD2_k127_4402298_1 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000391 83.0
HFD2_k127_4402298_2 Domain of unknown function (DUF4129) - - - 0.00001612 55.0
HFD2_k127_4402298_3 - - - - 0.0001673 53.0
HFD2_k127_4402352_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 488.0
HFD2_k127_4402352_1 Amino acid kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000003217 162.0
HFD2_k127_4402352_2 UPF0182 protein K09118 - - 0.000000000000000000003017 111.0
HFD2_k127_4405334_0 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 555.0
HFD2_k127_4405334_1 PFAM Glycosyl transferase, group 1 K08256 - 2.4.1.345 0.0000000000000000000000000000000009642 138.0
HFD2_k127_4406833_0 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 1.848e-220 705.0
HFD2_k127_4406833_1 Thiolase, C-terminal domain K00632 - 2.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006768 542.0
HFD2_k127_4406833_2 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006914 501.0
HFD2_k127_4406833_3 Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000005746 161.0
HFD2_k127_4406833_4 PFAM inositol monophosphatase - - - 0.00000000000000000000001569 106.0
HFD2_k127_4407605_0 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005572 610.0
HFD2_k127_4407605_1 beta' subunit K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000001042 174.0
HFD2_k127_4414382_0 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000000000000000006116 171.0
HFD2_k127_4414382_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000002571 138.0
HFD2_k127_4415732_0 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008888 527.0
HFD2_k127_4415732_1 PFAM LemA family K03744 - - 0.0000000000000000000000000000000000000000000001018 174.0
HFD2_k127_4427990_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001508 360.0
HFD2_k127_4427990_1 STAS domain K04749 - - 0.00000000000000000000000000000000000000002582 154.0
HFD2_k127_4427990_2 COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase) K04757 - 2.7.11.1 0.00000000000000000000504 98.0
HFD2_k127_4427990_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000000000001681 83.0
HFD2_k127_4428855_0 ABC transporter K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008129 390.0
HFD2_k127_4428855_1 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 307.0
HFD2_k127_443022_0 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 321.0
HFD2_k127_443022_1 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000004775 177.0
HFD2_k127_4430812_0 BON domain K04065 - - 0.00000000000000000000000000000000000000000000000000001405 201.0
HFD2_k127_4430812_3 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.00003115 55.0
HFD2_k127_4430812_4 PFAM Coenzyme PQQ synthesis protein D (PqqD) - - - 0.0002219 53.0
HFD2_k127_4430812_5 Transglutaminase-like superfamily - - - 0.0005671 49.0
HFD2_k127_4434907_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 2105.0
HFD2_k127_4434907_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043,K13797 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.0 1392.0
HFD2_k127_4434907_2 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005841 330.0
HFD2_k127_4434907_3 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005449 284.0
HFD2_k127_4434907_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000111 204.0
HFD2_k127_4434907_5 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000001781 177.0
HFD2_k127_4434907_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000005344 149.0
HFD2_k127_4434907_7 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000006455 139.0
HFD2_k127_4434907_8 Ribosomal protein L33 K02913 - - 0.000000000000000008861 84.0
HFD2_k127_4434907_9 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.000005122 53.0
HFD2_k127_4456572_0 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 466.0
HFD2_k127_4456572_1 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 332.0
HFD2_k127_4456572_2 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 317.0
HFD2_k127_4464840_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000104 286.0
HFD2_k127_4464840_1 Belongs to the MtfA family K09933 - - 0.000000000000000000000000000000000000000000000000000000000001599 223.0
HFD2_k127_4464840_2 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K16319 - 1.14.12.1 0.0000000000000000000000000000000000000000001001 164.0
HFD2_k127_4470078_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 1.536e-224 705.0
HFD2_k127_4470078_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000061 242.0
HFD2_k127_4470078_2 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000001644 160.0
HFD2_k127_4470078_3 SMART RNA-processing protein HAT helix repeating-containing protein - - - 0.00000006193 64.0
HFD2_k127_4470078_4 PFAM Tetratricopeptide repeat - - - 0.0000004185 62.0
HFD2_k127_4470974_0 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002579 306.0
HFD2_k127_4470974_1 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000001509 271.0
HFD2_k127_4470974_2 SIS domain K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000009912 205.0
HFD2_k127_4470974_3 ZIP Zinc transporter K07238,K16267 - - 0.00000000000000000000000000000000006952 139.0
HFD2_k127_4470974_4 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.00000000000001376 77.0
HFD2_k127_4482828_0 COG0798 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 470.0
HFD2_k127_4482828_1 Belongs to the PstS family K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 366.0
HFD2_k127_4482828_2 HAMP domain K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000003646 199.0
HFD2_k127_4482828_3 - - - - 0.000000000001072 79.0
HFD2_k127_4483675_0 Beta-eliminating lyase K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008678 488.0
HFD2_k127_4483675_1 OST-HTH/LOTUS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 389.0
HFD2_k127_4483675_2 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000006949 225.0
HFD2_k127_4483675_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000103 189.0
HFD2_k127_4483675_4 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000000000000000000000000000008713 175.0
HFD2_k127_44851_0 Glycogen debranching enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 343.0
HFD2_k127_44851_1 Bacterial Ig-like domain (group 2) - - - 0.0000000208 66.0
HFD2_k127_4490067_0 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 491.0
HFD2_k127_4490067_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008896 399.0
HFD2_k127_4490067_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009602 387.0
HFD2_k127_4490067_3 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.000000000000000000000008088 107.0
HFD2_k127_4496133_0 PFAM Glycosyl transferase family 2 - - - 6.305e-274 864.0
HFD2_k127_4496133_1 N-terminal TM domain of oligopeptide transport permease C K02034,K15582 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009876 335.0
HFD2_k127_4496133_2 4Fe-4S single cluster domain K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 298.0
HFD2_k127_4521479_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.926e-229 734.0
HFD2_k127_4521479_1 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 - 5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 323.0
HFD2_k127_4521479_2 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000002544 98.0
HFD2_k127_4523916_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 351.0
HFD2_k127_4523916_1 Cytochrome c K07243 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000551 285.0
HFD2_k127_4523916_2 Zn_pept - - - 0.0000000000000000000000000000000000000000000000000000000000000000606 253.0
HFD2_k127_4523916_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000001003 233.0
HFD2_k127_4523916_4 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000001301 203.0
HFD2_k127_4523916_5 CYTH domain K01768,K05873 - 4.6.1.1 0.0000000000000000000000000001642 130.0
HFD2_k127_4523916_6 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000007517 106.0
HFD2_k127_4523916_7 NlpC/P60 family - - - 0.0000001086 55.0
HFD2_k127_4524133_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 0.0 1062.0
HFD2_k127_4524133_1 cellular manganese ion homeostasis - - - 0.000000000000000000000000000000000000000000000005449 175.0
HFD2_k127_4524133_2 Methyl-accepting chemotaxis protein K02660,K11525 - - 0.00000000002417 78.0
HFD2_k127_4531973_0 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.0 1089.0
HFD2_k127_4531973_1 Alpha-amylase domain K01176 - 3.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007505 372.0
HFD2_k127_4531973_2 beta-galactosidase activity K01190 - 3.2.1.23 0.0000000000000000000000000000000000000000000000000000000000002131 217.0
HFD2_k127_4532778_0 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000002335 203.0
HFD2_k127_4532778_1 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.0000000000000000000000000000000000006216 157.0
HFD2_k127_4532778_2 PFAM Glycosyl transferase, group 1 K00754 - - 0.0000000000000000000000000000000006824 132.0
HFD2_k127_4532778_3 PFAM UbiA prenyltransferase K17105 - 2.5.1.42 0.000000000004129 77.0
HFD2_k127_4534541_0 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 347.0
HFD2_k127_4534541_1 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.00000000000000000000000000000000001434 139.0
HFD2_k127_4534541_2 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000004442 79.0
HFD2_k127_4534541_3 Forkhead associated domain - - - 0.000000006383 68.0
HFD2_k127_4539963_0 Hydrogenase formation hypA family K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 490.0
HFD2_k127_4539963_1 hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 463.0
HFD2_k127_4539963_2 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.0000000000000000000000000000000000000000000000000000000000001992 219.0
HFD2_k127_4539963_3 - - - - 0.000000000000000000000000000000000000000000001658 171.0
HFD2_k127_4539963_4 Enoyl-CoA hydratase carnithine racemase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000004107 172.0
HFD2_k127_4539963_5 carbon dioxide binding K04653,K04654 - - 0.00000000000000000000000000000006594 126.0
HFD2_k127_4539963_6 PFAM peptidase M52 hydrogen uptake protein K03605 - - 0.0000000000000000000000000000003397 129.0
HFD2_k127_4539963_7 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 GO:0000287,GO:0003674,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0034641,GO:0042558,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0046653,GO:0046872,GO:0051186,GO:0071704,GO:1901360,GO:1901564 2.1.2.2 0.0000000000000000431 91.0
HFD2_k127_4539963_8 SNARE associated Golgi protein - - - 0.0000000000000004815 81.0
HFD2_k127_4539963_9 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0001851 48.0
HFD2_k127_4552335_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 4.663e-304 945.0
HFD2_k127_4552335_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000438 338.0
HFD2_k127_4552335_2 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005362 275.0
HFD2_k127_4552335_3 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000004184 252.0
HFD2_k127_4552335_4 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000009885 239.0
HFD2_k127_4552335_5 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000001866 116.0
HFD2_k127_4562700_0 impB/mucB/samB family K02346 - 2.7.7.7 0.000000000000000000000003244 107.0
HFD2_k127_4562700_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000005847 97.0
HFD2_k127_4562700_2 Cupin 2, conserved barrel domain protein - - - 0.000000000001529 73.0
HFD2_k127_4562700_3 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000000002074 70.0
HFD2_k127_4572890_0 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 289.0
HFD2_k127_4572890_1 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000007192 194.0
HFD2_k127_4572890_2 Adenylate cyclase - - - 0.00000000000000000003595 104.0
HFD2_k127_4572890_3 Carboxymuconolactone decarboxylase - - - 0.00008255 53.0
HFD2_k127_4574178_0 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 525.0
HFD2_k127_4574178_1 Modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006149 396.0
HFD2_k127_4574178_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000004138 188.0
HFD2_k127_4574178_3 Phosphoribosyl transferase domain K07101 - - 0.000000000000000000000000000000000000000000006412 177.0
HFD2_k127_4574178_4 - - - - 0.00000000000000004565 89.0
HFD2_k127_4574178_5 Modulator of DNA gyrase K03592 - - 0.0006962 51.0
HFD2_k127_4587171_0 iron ion homeostasis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071 334.0
HFD2_k127_4587171_1 DNA-templated transcription, initiation - - - 0.00000000000000000000000000006091 119.0
HFD2_k127_4592129_0 lysine biosynthetic process via aminoadipic acid - - - 6.208e-275 867.0
HFD2_k127_4592129_1 ROK family K00847 - 2.7.1.4 0.00000000000000000000000000000000000000000000000000000000000000000004113 236.0
HFD2_k127_4592129_2 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000006967 200.0
HFD2_k127_4596927_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 3.158e-224 718.0
HFD2_k127_4596927_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 520.0
HFD2_k127_4596927_10 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000001148 67.0
HFD2_k127_4596927_2 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 473.0
HFD2_k127_4596927_3 Nucleotidyl transferase K00971 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001055 298.0
HFD2_k127_4596927_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002188 266.0
HFD2_k127_4596927_5 Sugar nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006208 273.0
HFD2_k127_4596927_6 Roadblock/LC7 domain K07131 - - 0.0000000000000000000000000005564 116.0
HFD2_k127_4596927_7 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.00000000000000005503 91.0
HFD2_k127_4596927_8 cheY-homologous receiver domain - - - 0.00000000000000006376 89.0
HFD2_k127_4596927_9 - - - - 0.000000000000002086 83.0
HFD2_k127_4603137_0 Carbohydrate family 9 binding domain-like - - - 5.273e-259 812.0
HFD2_k127_4603137_1 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 322.0
HFD2_k127_4603137_2 Peptidase dimerisation domain K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000008357 258.0
HFD2_k127_4603137_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000006323 261.0
HFD2_k127_4603137_4 Belongs to the ATCase OTCase family K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0043857,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000002139 231.0
HFD2_k127_4603137_5 Regulates arginine biosynthesis genes K03402 - - 0.000000000000000000000005176 107.0
HFD2_k127_4616456_0 protein secretion by the type I secretion system K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004289 564.0
HFD2_k127_4616456_1 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008137 497.0
HFD2_k127_4624893_0 homoserine kinase activity K00823,K07250 - 2.6.1.19,2.6.1.22 0.0 1042.0
HFD2_k127_4624893_1 MafB19-like deaminase K01485 - 3.5.4.1 0.00000000000000000000000000000000000000000000000000000000000002278 233.0
HFD2_k127_4624893_10 Outer membrane protein beta-barrel domain - - - 0.000009895 55.0
HFD2_k127_4624893_2 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.0000000000000000000000000000000000000000000000000000000000003495 222.0
HFD2_k127_4624893_3 L-lysine catabolic process to acetate K18013 - 2.3.1.247 0.00000000000000000000000000000000000000000000000000000000008509 222.0
HFD2_k127_4624893_4 HAD-hyrolase-like K19270 - 3.1.3.23 0.0000000000000000000000000000000000000000000000003894 189.0
HFD2_k127_4624893_5 - - - - 0.00000000000000000000000000000000000000000000001305 178.0
HFD2_k127_4624893_6 Protein of unknown function (DUF3303) - - - 0.00000000000000000000000000000005128 126.0
HFD2_k127_4624893_7 TonB dependent receptor K02014 - - 0.000000000000000000000006795 115.0
HFD2_k127_4624893_8 Acetyltransferase (GNAT) domain - - - 0.00000000000004039 76.0
HFD2_k127_4626538_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009187 594.0
HFD2_k127_4626538_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 415.0
HFD2_k127_4626538_2 protein kinase activity - - - 0.000000000000000000000000000000000000000000000001045 181.0
HFD2_k127_4626538_3 Peptidase family M28 K06016 - 3.5.1.6,3.5.1.87 0.0000000000000000000000000000000000000000181 155.0
HFD2_k127_4636294_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 595.0
HFD2_k127_4636294_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003837 572.0
HFD2_k127_4636294_2 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 460.0
HFD2_k127_4636294_3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007806 433.0
HFD2_k127_4636294_4 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009537 404.0
HFD2_k127_4636294_5 Phage integrase, N-terminal SAM-like domain K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 326.0
HFD2_k127_4636294_6 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000000004334 269.0
HFD2_k127_4636294_7 Probable molybdopterin binding domain K03831 - 2.7.7.75 0.00000000000000000000000000000000000000000000006571 183.0
HFD2_k127_4636294_8 Thioesterase K07107 - - 0.000000000000000000000000000000000000001033 161.0
HFD2_k127_4642000_0 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006781 306.0
HFD2_k127_4668770_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001399 262.0
HFD2_k127_4668770_1 Regulator of chromosome condensation (RCC1) repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006594 259.0
HFD2_k127_4668770_2 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000004135 117.0
HFD2_k127_4668770_3 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000004731 122.0
HFD2_k127_4682245_0 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004378 256.0
HFD2_k127_4682245_1 Uncharacterized conserved protein (DUF2249) - - - 0.0000000000000000000000000003546 116.0
HFD2_k127_4682245_2 Dehydrogenase E1 component K00164,K01616 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0030312,GO:0032991,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0050439,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 0.00000000000000000001676 97.0
HFD2_k127_4682245_3 Iron-sulfur cluster assembly protein - - - 0.000000000000000002465 99.0
HFD2_k127_4682245_4 Transcriptional regulator - - - 0.000000000001748 73.0
HFD2_k127_4682245_5 Uncharacterized conserved protein (DUF2249) - - - 0.00000000001048 75.0
HFD2_k127_4686254_0 HELICc2 K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003031 361.0
HFD2_k127_4686254_1 Endoribonuclease L-PSP - - - 0.000000000000001483 83.0
HFD2_k127_4700951_0 Pyridoxal-dependent decarboxylase conserved domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 581.0
HFD2_k127_4700951_1 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087,K16055 GO:0003674,GO:0003824,GO:0004805,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044464,GO:0046351,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:1901576 2.4.1.15,3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007919 568.0
HFD2_k127_4700951_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 346.0
HFD2_k127_4700951_3 CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000001443 112.0
HFD2_k127_4720972_0 with chaperone activity ATP-binding K03696 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 518.0
HFD2_k127_4720972_1 ATP:guanido phosphotransferase, C-terminal catalytic domain K19405 - 2.7.14.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 441.0
HFD2_k127_4720972_2 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.0000000000000000000000000000000000000000000000000000002713 197.0
HFD2_k127_4720972_3 UvrB/uvrC motif K19411 - - 0.0000000000000000000000000000000000000002543 161.0
HFD2_k127_4756141_0 Formate dehydrogenase alpha subunit K00123,K05299 - 1.17.1.10,1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004842 603.0
HFD2_k127_4756141_1 Zinc-binding dehydrogenase K00060 - 1.1.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 458.0
HFD2_k127_4756141_2 Beta-eliminating lyase K00639 - 2.3.1.29 0.00000000000000000000000000000000000000001045 168.0
HFD2_k127_4773143_0 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004771 313.0
HFD2_k127_4773143_1 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000002739 157.0
HFD2_k127_4773143_2 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.0000000000000002554 85.0
HFD2_k127_4791767_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007183 513.0
HFD2_k127_4795838_0 fatty acid desaturase K10255 - 1.14.19.23,1.14.19.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 374.0
HFD2_k127_4795838_1 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.000000000000000000000000000000000000000000000000000000001778 215.0
HFD2_k127_4795838_2 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000003546 202.0
HFD2_k127_4795838_3 Ribonuclease B OB domain K03704 - - 0.0000000000000000000000000000001432 127.0
HFD2_k127_4795838_4 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000009373 122.0
HFD2_k127_4795838_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000127 93.0
HFD2_k127_4795838_6 Ribosomal protein S21 K02970 - - 0.0000000003843 64.0
HFD2_k127_4796483_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000008231 221.0
HFD2_k127_4796483_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000009463 198.0
HFD2_k127_4797370_0 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001141 283.0
HFD2_k127_4797370_1 Ankyrin repeats (many copies) - - - 0.000000000000000000000000000000000000004884 153.0
HFD2_k127_4797370_2 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000001583 73.0
HFD2_k127_4797370_3 AP2 domain - - - 0.0005155 46.0
HFD2_k127_4858151_1 cellulose binding - - - 0.000000000000000000000000000000000006939 141.0
HFD2_k127_4858151_2 ERAP1-like C-terminal domain K01256 - 3.4.11.2 0.00000000000000000000001341 101.0
HFD2_k127_4858151_3 Virulence activator alpha C-term - - - 0.0000000000000000000165 101.0
HFD2_k127_4872788_0 ADP binding - - - 0.00000000000000000000000000000005016 144.0
HFD2_k127_4872788_1 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000003754 60.0
HFD2_k127_4890987_0 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 464.0
HFD2_k127_4890987_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009112 449.0
HFD2_k127_4890987_10 Peptidase family S41 K03797 - 3.4.21.102 0.000000000000000000000003809 112.0
HFD2_k127_4890987_11 Transcriptional regulator K22106 - - 0.000000000003297 74.0
HFD2_k127_4890987_12 metallophosphoesterase - - - 0.00000000167 71.0
HFD2_k127_4890987_2 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 404.0
HFD2_k127_4890987_3 Asparaginase K01444 - 3.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 376.0
HFD2_k127_4890987_4 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008997 312.0
HFD2_k127_4890987_5 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004224 258.0
HFD2_k127_4890987_6 Thrombospondin type 3 repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000005873 246.0
HFD2_k127_4890987_7 Thioredoxin - - - 0.0000000000000000000000000000000000000000000002571 174.0
HFD2_k127_4890987_8 Belongs to the ompA family K03286 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000000000000000002683 129.0
HFD2_k127_4890987_9 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281 - 3.5.1.19 0.00000000000000000000000003155 125.0
HFD2_k127_4925479_0 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006575 529.0
HFD2_k127_4925479_1 iron-sulfur cluster assembly K07400 - - 0.0000000000000000000000000000000000000007258 156.0
HFD2_k127_4925479_2 ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp - - - 0.000000000000000000000000000000000001099 145.0
HFD2_k127_4949017_0 Bacterial membrane protein YfhO - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002211 299.0
HFD2_k127_4949017_1 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001366 239.0
HFD2_k127_4949017_2 Hexapeptide repeat of succinyl-transferase K00661 - 2.3.1.79 0.0000000000000000000000000000000000006098 146.0
HFD2_k127_4949017_3 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000001356 141.0
HFD2_k127_4949017_4 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000000001786 133.0
HFD2_k127_4949017_5 40-residue YVTN family beta-propeller repeat protein - - - 0.00000000000000004554 94.0
HFD2_k127_4949017_6 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.0000000000002804 83.0
HFD2_k127_4949017_7 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000004832 72.0
HFD2_k127_4949017_8 40-residue YVTN family beta-propeller repeat - - - 0.000000004964 69.0
HFD2_k127_4978381_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 560.0
HFD2_k127_4978381_1 Insulinase (Peptidase family M16) K07263 - - 0.000000000000004841 87.0
HFD2_k127_4979844_0 Peptidase family S58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003229 252.0
HFD2_k127_4979844_1 lipid kinase activity - - - 0.00000000000000000000000000000000000001587 158.0
HFD2_k127_4979844_2 NlpC/P60 family - - - 0.0000000000000000000000000000000000345 152.0
HFD2_k127_4979844_3 HD domain - - - 0.0000000000000000000000000000328 128.0
HFD2_k127_4979844_4 response regulator K07714 - - 0.00001389 54.0
HFD2_k127_4979844_5 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.0007059 49.0
HFD2_k127_4990354_0 cellulose binding - - - 4.053e-206 656.0
HFD2_k127_5053588_0 long-chain fatty acid transport protein - - - 0.0000000000000000000000000008524 127.0
HFD2_k127_5053588_1 Peptidase M56 - - - 0.00000000000000000000000466 118.0
HFD2_k127_5053588_3 cytochrome oxidase assembly K02259 - - 0.0000156 51.0
HFD2_k127_5109049_0 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 523.0
HFD2_k127_5109049_1 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008363 375.0
HFD2_k127_5109049_2 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000001378 149.0
HFD2_k127_5109049_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000008751 99.0
HFD2_k127_511808_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000975 482.0
HFD2_k127_511808_1 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005892 483.0
HFD2_k127_5144150_0 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005322 528.0
HFD2_k127_5144150_1 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 300.0
HFD2_k127_5144150_2 lipoprotein transporter activity K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001711 258.0
HFD2_k127_525646_0 Sigma-70, region 4 K03088 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000001957 220.0
HFD2_k127_525646_1 PFAM pentapeptide repeat protein - - - 0.0000000000000006411 85.0
HFD2_k127_5265303_0 helicase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 382.0
HFD2_k127_5265303_1 COG0577 ABC-type antimicrobial peptide transport system permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000003018 233.0
HFD2_k127_5265303_2 TIGRFAM Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000007065 209.0
HFD2_k127_5265303_3 Putative restriction endonuclease - - - 0.0000000000000000000000000000000000000000009613 165.0
HFD2_k127_5265303_4 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000003417 152.0
HFD2_k127_5265303_5 helicase K03580 - - 0.00003472 57.0
HFD2_k127_5271290_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 411.0
HFD2_k127_5271290_1 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000039 287.0
HFD2_k127_5271290_2 Zn peptidase - - - 0.00000000000000000000000000004848 125.0
HFD2_k127_5271290_3 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000154 102.0
HFD2_k127_5276956_0 LytB protein K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 530.0
HFD2_k127_5276956_1 DEAD DEAH box helicase K03724 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 287.0
HFD2_k127_5276956_2 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000103 250.0
HFD2_k127_5276956_3 Thioesterase superfamily K07107 - - 0.000000000000000000000001541 108.0
HFD2_k127_5276956_4 Positively regulates the dhaKLM operon from a sigma-70 promoter K05880 GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.00000008695 57.0
HFD2_k127_5285232_0 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 4.483e-198 629.0
HFD2_k127_5285232_1 ABC transporter K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009252 426.0
HFD2_k127_5285232_2 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008441 351.0
HFD2_k127_5285232_3 - - - - 0.00000000000000000000000000000000000000000000276 182.0
HFD2_k127_5285232_4 Lipopolysaccharide-assembly, LptC-related - - - 0.000000000000000000000000000001222 126.0
HFD2_k127_5290062_0 protein secretion by the type I secretion system K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 579.0
HFD2_k127_5300165_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004854 570.0
HFD2_k127_5300165_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006493 560.0
HFD2_k127_5300165_2 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 422.0
HFD2_k127_5300165_3 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 383.0
HFD2_k127_5300165_4 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000002059 143.0
HFD2_k127_5300165_5 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000002699 122.0
HFD2_k127_5300165_6 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000007999 110.0
HFD2_k127_5300165_7 Ribosomal protein L34 K02914 - - 0.00000000000000003571 89.0
HFD2_k127_5300165_8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 GO:0008150,GO:0040007 3.1.26.5 0.000003436 55.0
HFD2_k127_5301235_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 388.0
HFD2_k127_5301235_1 PFAM histone deacetylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 356.0
HFD2_k127_5301235_2 Yip1 domain - - - 0.000000000001277 78.0
HFD2_k127_5317642_0 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004843 378.0
HFD2_k127_5317642_1 peptidyl-tyrosine sulfation - - - 0.000000003582 70.0
HFD2_k127_5317642_2 Histidine kinase K07677 - 2.7.13.3 0.0001812 44.0
HFD2_k127_5330858_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1211.0
HFD2_k127_5330858_1 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 387.0
HFD2_k127_5330858_2 - - - - 0.000000000000000000000000000000000000000000001669 175.0
HFD2_k127_5330858_3 Bacterial periplasmic substrate-binding proteins - - - 0.000000000000000000000000000004901 128.0
HFD2_k127_5338701_0 Polyprenyl synthetase K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002724 380.0
HFD2_k127_5338701_1 SurA N-terminal domain K03770 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000496 376.0
HFD2_k127_5338701_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001346 293.0
HFD2_k127_5338701_3 Amidohydrolase family K01468 - 3.5.2.7 0.000000000000000000000001994 105.0
HFD2_k127_5338701_4 Domain of unknown function (DUF4321) - - - 0.000000000000000000002514 104.0
HFD2_k127_5338701_5 Tetratricopeptide repeat - - - 0.0000000008438 61.0
HFD2_k127_5338701_6 protein secretion K03116 GO:0008150,GO:0040007 - 0.00000002304 63.0
HFD2_k127_5339904_0 mannose metabolic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000003503 255.0
HFD2_k127_5339904_1 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000003883 166.0
HFD2_k127_5344369_0 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008853 323.0
HFD2_k127_5344369_1 Protein of unknown function, DUF - - - 0.000000000000000000000000000000000000000000005738 169.0
HFD2_k127_5344369_2 Cysteine-rich CPXCG - - - 0.00000000000000000000000009204 116.0
HFD2_k127_5344369_3 Redoxin K03564 - 1.11.1.15 0.000000000000000000002239 97.0
HFD2_k127_5344369_4 Poly(hydroxyalcanoate) granule associated protein (phasin) - - - 0.00000000000000001207 86.0
HFD2_k127_5344369_5 PHB/PHA accumulation regulator DNA-binding domain - - - 0.00000000000006308 79.0
HFD2_k127_5346754_0 PFAM Glycosyl transferase family 2 - - - 1.657e-219 695.0
HFD2_k127_5346754_1 ABC-type multidrug transport system ATPase and permease K06147 - - 7.324e-195 623.0
HFD2_k127_5346754_2 peptidoglycan turnover - - - 0.0000001638 63.0
HFD2_k127_5351260_0 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007851 317.0
HFD2_k127_5351260_1 nuclear chromosome segregation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 335.0
HFD2_k127_5351260_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000002416 257.0
HFD2_k127_5351260_3 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000002839 234.0
HFD2_k127_5351260_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.00000000000000000000000000000000000000000228 158.0
HFD2_k127_5351260_5 Thioredoxin-like domain K03671 - - 0.0000000000000000000000000000000000000474 154.0
HFD2_k127_5351260_6 - - - - 0.00000000000000000002642 102.0
HFD2_k127_53573_0 PBP superfamily domain K05772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007465 296.0
HFD2_k127_53573_1 Putative phosphatase (DUF442) - - - 0.000000000001507 74.0
HFD2_k127_53573_2 Domain of unknown function (DUF1772) - - - 0.00001029 52.0
HFD2_k127_53573_3 PFAM PEGA domain - - - 0.0007801 47.0
HFD2_k127_5368246_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 546.0
HFD2_k127_5368246_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006096 458.0
HFD2_k127_5368246_2 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000000000000000000000006123 258.0
HFD2_k127_5368246_3 Protein of unknown function (DUF520) K09767 - - 0.000000000000000000000000000000000000000000000000000000005946 209.0
HFD2_k127_5368246_4 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.00000000000000000000000000000000003881 137.0
HFD2_k127_5368246_5 Homoserine dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000002357 131.0
HFD2_k127_5368246_6 - - - - 0.00000000000000002932 96.0
HFD2_k127_5375843_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001161 279.0
HFD2_k127_5375843_1 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007572 272.0
HFD2_k127_5375843_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000004881 177.0
HFD2_k127_5375843_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000001194 117.0
HFD2_k127_5375843_4 PFAM Flavin - - - 0.00000000000001428 81.0
HFD2_k127_5385823_0 - - - - 0.000000000000000000000000000000000005273 151.0
HFD2_k127_5385823_1 protein transport across the cell outer membrane K02246,K08084 - - 0.0001064 52.0
HFD2_k127_5385823_2 pilus assembly protein PilW K02672 - - 0.0007822 51.0
HFD2_k127_5387381_0 PAS domain K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008279 392.0
HFD2_k127_5387381_1 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000004732 166.0
HFD2_k127_5413837_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006513 529.0
HFD2_k127_5413837_1 Transcription factor zinc-finger K09981 - - 0.0000000000000005321 84.0
HFD2_k127_5424153_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 480.0
HFD2_k127_5424153_1 COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 0.000000000000000000006753 100.0
HFD2_k127_5430031_0 Voltage gated chloride channel - - - 2.394e-194 619.0
HFD2_k127_5430031_1 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 434.0
HFD2_k127_5430031_2 - - - - 0.00000000004749 64.0
HFD2_k127_5430031_3 - - - - 0.00000002174 64.0
HFD2_k127_5432620_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006904 411.0
HFD2_k127_5432620_1 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K00857,K01920,K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.21,6.3.2.3,6.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009188 334.0
HFD2_k127_5432620_2 23S rRNA-intervening sequence protein - - - 0.0000000000000005865 87.0
HFD2_k127_5432620_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde - - - 0.00005899 51.0
HFD2_k127_5433729_0 malic enzyme K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 4.865e-269 848.0
HFD2_k127_5433729_1 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 5.79e-237 744.0
HFD2_k127_5433729_2 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 421.0
HFD2_k127_5434691_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000001526 217.0
HFD2_k127_5434691_1 luxR family - - - 0.000000000000000000000000000007288 122.0
HFD2_k127_5434691_2 Iron-regulated membrane protein - - - 0.000000000000000000000000002143 126.0
HFD2_k127_5457666_0 xanthine dehydrogenase activity K04108 - 1.3.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 588.0
HFD2_k127_5457666_1 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000003454 220.0
HFD2_k127_5457666_2 Dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000002807 188.0
HFD2_k127_5469231_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 546.0
HFD2_k127_5469231_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000001066 182.0
HFD2_k127_5469231_2 Lumazine binding domain K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000003432 182.0
HFD2_k127_5504334_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 564.0
HFD2_k127_5504334_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 539.0
HFD2_k127_5504334_10 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000008196 137.0
HFD2_k127_5504334_11 Cytochrome c - - - 0.00000000000000000000000000007386 130.0
HFD2_k127_5504334_12 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000866 121.0
HFD2_k127_5504334_13 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000001152 125.0
HFD2_k127_5504334_14 PTS HPr component phosphorylation site K11189 - - 0.000000000000000000001506 107.0
HFD2_k127_5504334_15 PTS system sorbose-specific iic component K02795 - - 0.000000000000000009958 94.0
HFD2_k127_5504334_16 system, fructose subfamily IIA component K02793,K02794 - 2.7.1.191 0.000000004435 63.0
HFD2_k127_5504334_2 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 410.0
HFD2_k127_5504334_3 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 399.0
HFD2_k127_5504334_4 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01007,K08483 - 2.7.3.9,2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 394.0
HFD2_k127_5504334_5 PTS system sorbose subfamily IIB component K19507 - - 0.000000000000000000000000000000000000000000000000000000001883 208.0
HFD2_k127_5504334_6 PTS system mannose/fructose/sorbose family IID component K02796 - - 0.00000000000000000000000000000000000000000000000001481 199.0
HFD2_k127_5504334_7 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000007212 181.0
HFD2_k127_5504334_8 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000004597 169.0
HFD2_k127_5504334_9 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000003521 154.0
HFD2_k127_5508075_0 Putative aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002968 291.0
HFD2_k127_5508075_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000005717 152.0
HFD2_k127_5508075_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000001956 147.0
HFD2_k127_5520514_0 Esterase PHB depolymerase K03932 - - 0.000000000000000000000000000000000000000000004566 177.0
HFD2_k127_5520514_1 acetyltransferase K03827 - - 0.0000000000000000000000000000000000000001296 154.0
HFD2_k127_5520514_2 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000123 129.0
HFD2_k127_5520514_3 Thioesterase-like superfamily K07107 - - 0.00000000000000001139 85.0
HFD2_k127_5520514_4 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000002928 86.0
HFD2_k127_5528272_0 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 282.0
HFD2_k127_5528272_1 thiolester hydrolase activity K06889 - - 0.000000000000000000000000000638 127.0
HFD2_k127_5528272_2 - - - - 0.000000000001025 70.0
HFD2_k127_5529525_0 LacI family K02529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006969 319.0
HFD2_k127_5529525_1 HTH domain - - - 0.0000002052 55.0
HFD2_k127_5554332_0 Curli production assembly/transport component CsgG - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001591 275.0
HFD2_k127_5556773_0 Domain of unknown function (DUF3471) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000589 489.0
HFD2_k127_5556773_1 Domain of unknown function (DUF4112) - - - 0.000000000000000000000000001361 115.0
HFD2_k127_5566431_0 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008353 500.0
HFD2_k127_5566431_1 Glycine cleavage T-protein C-terminal barrel domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000588 453.0
HFD2_k127_5569594_0 Fibronectin type 3 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000123 313.0
HFD2_k127_5569594_1 aminopeptidase N - - - 0.00000000000000000000000000000007955 139.0
HFD2_k127_5569594_2 Belongs to the peptidase S8 family K14645 GO:0005575,GO:0005576 - 0.00000000001145 79.0
HFD2_k127_5581173_0 regulation of response to stimulus - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007347 508.0
HFD2_k127_5581173_1 response to abiotic stimulus K03086,K06867 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 430.0
HFD2_k127_5581173_2 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000004962 113.0
HFD2_k127_5587316_0 Clp amino terminal domain, pathogenicity island component K03696 - - 2.271e-244 760.0
HFD2_k127_5587316_1 Surface antigen K07277 - - 1.003e-241 771.0
HFD2_k127_5587316_2 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 484.0
HFD2_k127_5587316_3 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 341.0
HFD2_k127_5587316_4 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000645 333.0
HFD2_k127_5587316_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 324.0
HFD2_k127_5587316_6 Outer membrane protein (OmpH-like) K06142 - - 0.000000000000001459 86.0
HFD2_k127_5598765_0 Ami_2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 404.0
HFD2_k127_5598765_1 peptidase - - - 0.000000000000000000000000000000000000001756 162.0
HFD2_k127_5605190_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 3.218e-252 785.0
HFD2_k127_5610165_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007742 466.0
HFD2_k127_5610165_1 ABC transporter K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004069 366.0
HFD2_k127_5610165_2 ABC-2 family transporter protein K01992 - - 0.0000000000001637 75.0
HFD2_k127_5619595_0 beta-galactosidase activity K15855 GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044238,GO:0071704,GO:1901575 3.2.1.165 1.277e-262 824.0
HFD2_k127_5641921_0 aminotransferase class I and II K00375 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000877 475.0
HFD2_k127_5641921_1 HD domain K07023 - - 0.00000000000000000000002393 102.0
HFD2_k127_5643077_0 Zn-dependent protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 361.0
HFD2_k127_5643077_1 Domain in cystathionine beta-synthase and other proteins. K01697 - 4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 349.0
HFD2_k127_5643077_2 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000591 336.0
HFD2_k127_5643077_3 Rhomboid family - - - 0.00000000000000000000000000000000000009988 153.0
HFD2_k127_5643077_4 peptidyl-tyrosine sulfation - - - 0.0000001258 65.0
HFD2_k127_5645956_0 Fibronectin type 3 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000813 459.0
HFD2_k127_5665321_0 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009975 346.0
HFD2_k127_5665321_1 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000003932 126.0
HFD2_k127_5665321_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000004969 123.0
HFD2_k127_5674935_0 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000003979 269.0
HFD2_k127_5674935_1 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002609 268.0
HFD2_k127_5674935_2 D-aminopeptidase K16203 - - 0.00000000000000000000000000000000000000000000000000000000000000000001312 238.0
HFD2_k127_5674935_3 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000002833 200.0
HFD2_k127_5674935_4 Phenazine biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000004233 196.0
HFD2_k127_5674935_5 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000004554 147.0
HFD2_k127_5674935_6 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000002232 143.0
HFD2_k127_5696844_0 ASPIC UnbV domain protein - - - 0.0 1318.0
HFD2_k127_5696844_1 PAP2 superfamily - - - 0.0000000000000000000000000000001363 126.0
HFD2_k127_5707739_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.376e-319 989.0
HFD2_k127_5729379_0 Peptidase family M13 K07386 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 592.0
HFD2_k127_5729379_1 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00499,K16319 - 1.14.12.1,1.14.15.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 349.0
HFD2_k127_5729379_2 SMART helix-turn-helix- domain containing protein, AraC type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006124 327.0
HFD2_k127_5729379_3 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007522 328.0
HFD2_k127_5729379_4 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004613 286.0
HFD2_k127_5729379_5 Evidence 4 Homologs of previously reported genes of K15977 - - 0.0000000000000000000000000000000000000000002362 162.0
HFD2_k127_5729379_6 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000001698 128.0
HFD2_k127_5729379_7 transport - - - 0.000000000000000004987 95.0
HFD2_k127_5729379_8 - - - - 0.00000000000000001708 88.0
HFD2_k127_5738784_0 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006383 409.0
HFD2_k127_5738784_1 - - - - 0.00000000000000000000000000000000000000002466 165.0
HFD2_k127_5767791_0 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 304.0
HFD2_k127_5767791_1 DinB family - - - 0.0001062 51.0
HFD2_k127_5767791_2 WG containing repeat - - - 0.0002344 52.0
HFD2_k127_5772_0 Beta-eliminating lyase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000003321 198.0
HFD2_k127_5772_1 proteolysis K03665 - - 0.0000009057 61.0
HFD2_k127_5819971_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007782 363.0
HFD2_k127_5819971_1 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 326.0
HFD2_k127_5828990_0 PFAM extracellular solute-binding protein family 1 K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005375 332.0
HFD2_k127_5828990_1 COG1176 ABC-type spermidine putrescine transport system, permease component I K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 328.0
HFD2_k127_5828990_2 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052,K11072 - 3.6.3.31 0.0000000000000000000000002152 110.0
HFD2_k127_5847725_0 Amylo-alpha-1,6-glucosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 410.0
HFD2_k127_5847725_1 Belongs to the ABC transporter superfamily K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 357.0
HFD2_k127_5847725_2 Regulator of chromosome condensation (RCC1) repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000003682 246.0
HFD2_k127_5847725_3 Extracellular solute-binding protein K02027 - - 0.000000000000000000000000002313 128.0
HFD2_k127_5941692_0 PglZ domain - - - 4.409e-197 631.0
HFD2_k127_5941692_1 ABC transporter transmembrane region K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 505.0
HFD2_k127_5941692_10 transferase activity, transferring glycosyl groups K00754 - - 0.00000000003291 70.0
HFD2_k127_5941692_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007888 394.0
HFD2_k127_5941692_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 323.0
HFD2_k127_5941692_4 transferase activity, transferring glycosyl groups K00713,K06338 - - 0.000000000000000000000000000000000000000000000000000001302 203.0
HFD2_k127_5941692_5 DnaB-like helicase C terminal domain K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000378 200.0
HFD2_k127_5941692_6 PFAM glycosyl transferase family 9 K02843 - - 0.00000000000000000000000000000000000000000000000000006053 199.0
HFD2_k127_5941692_7 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000002225 207.0
HFD2_k127_5941692_8 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000004636 179.0
HFD2_k127_5941692_9 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000004548 168.0
HFD2_k127_5974853_0 Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001253 259.0
HFD2_k127_5974853_1 PDZ domain - - - 0.00000000000000000000009084 108.0
HFD2_k127_60736_0 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000000000000000000000000000005511 197.0
HFD2_k127_60736_1 NmrA-like family - - - 0.0000000000000000000000000000000000000000000000000004089 197.0
HFD2_k127_60736_2 - - - - 0.00000000000000000003223 91.0
HFD2_k127_60736_3 Protein of unknown function (DUF1697) - - - 0.0009359 48.0
HFD2_k127_6136936_0 DNA restriction-modification system - - - 0.000000000000000000000000000000000000000000000000000000000001076 228.0
HFD2_k127_6136936_1 - - - - 0.00000000000000000000000000000000000000000000012 179.0
HFD2_k127_6136936_2 Putative adhesin - - - 0.00000000000000000000000004594 117.0
HFD2_k127_6145039_0 PFAM Mo-dependent nitrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000168 256.0
HFD2_k127_6145039_1 methylated-DNA-[protein]-cysteine S-methyltransferase activity K00567,K10778 GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.63 0.000000000000000000000000000000000000000000000000003955 197.0
HFD2_k127_6145039_2 helix_turn_helix, Arsenical Resistance Operon Repressor K03892,K21903 - - 0.000000000000000000000000000001313 123.0
HFD2_k127_6145039_3 Patatin-like phospholipase - - - 0.000000000000000000000002966 118.0
HFD2_k127_6147435_0 Metallopeptidase family M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 342.0
HFD2_k127_6147435_1 transport - - - 0.000000000000002268 81.0
HFD2_k127_6147984_0 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor K00404,K00405,K15862 GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 2.233e-201 648.0
HFD2_k127_6147984_1 PFAM binding-protein-dependent transport systems inner membrane component K02025,K17242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000114 301.0
HFD2_k127_6147984_2 glycerophosphodiester transmembrane transport K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001091 263.0
HFD2_k127_6147984_3 Belongs to the heme-copper respiratory oxidase family K15862 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000806 269.0
HFD2_k127_6147984_4 N-terminal domain of cytochrome oxidase-cbb3, FixP K00406 - - 0.000000000000000000000000000000001896 136.0
HFD2_k127_6147984_5 biogenesis protein K09792 - - 0.000000000000001866 89.0
HFD2_k127_6148878_0 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 8.778e-249 781.0
HFD2_k127_6148878_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002847 291.0
HFD2_k127_6148878_2 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003697 271.0
HFD2_k127_6148878_3 PFAM Na dependent nucleoside transporter K03317 - - 0.00000000000000000000000000000000000000000000000000000000000000000009256 233.0
HFD2_k127_6148878_4 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000000000000000000000000000008813 239.0
HFD2_k127_6148878_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000001778 233.0
HFD2_k127_6148878_6 - - - - 0.0000000000000000000000000000000000000000000000000000002165 202.0
HFD2_k127_6148878_7 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000007489 189.0
HFD2_k127_6149041_0 Putative ATP-binding cassette K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 360.0
HFD2_k127_6149041_1 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002098 257.0
HFD2_k127_6149041_2 PFAM transglutaminase domain protein - - - 0.000000000000000000000000000007536 137.0
HFD2_k127_6149041_3 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.0000000000005049 80.0
HFD2_k127_6149041_4 Tetratricopeptide repeat - - - 0.000000003314 64.0
HFD2_k127_6160398_0 amino acid K03294,K13868 - - 0.0000000000000000000000000000000000000000000000000000000000009595 229.0
HFD2_k127_6160398_1 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000000000004661 149.0
HFD2_k127_6160398_2 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000002762 96.0
HFD2_k127_6160398_3 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000006813 79.0
HFD2_k127_6165370_0 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 321.0
HFD2_k127_6168976_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 5.92e-245 767.0
HFD2_k127_6168976_1 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000002657 95.0
HFD2_k127_6168976_2 PFAM Peptidase M22, glycoprotease K14742 - - 0.0000000000000000004078 99.0
HFD2_k127_6168976_3 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.000000000000008187 79.0
HFD2_k127_6171088_0 Amidohydrolase family - - - 2.24e-308 968.0
HFD2_k127_6171774_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261,K00262 - 1.4.1.3,1.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 449.0
HFD2_k127_6171774_1 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 436.0
HFD2_k127_6171774_2 - - - - 0.0000000000000000000000000000000000000000000000000003798 196.0
HFD2_k127_6171774_3 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000000000000001989 194.0
HFD2_k127_6171774_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000719 129.0
HFD2_k127_6171774_5 cAMP biosynthetic process K12132 - 2.7.11.1 0.0000000001504 74.0
HFD2_k127_6171774_6 Tetratricopeptide repeats - - - 0.000006045 59.0
HFD2_k127_6172716_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005256 454.0
HFD2_k127_6172716_1 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004693 340.0
HFD2_k127_6172716_2 HIT domain K02503 - - 0.00000000000000000000000000000000002753 150.0
HFD2_k127_6172716_3 Yqey-like protein K09117 - - 0.000000000000000000000000000000001165 134.0
HFD2_k127_6172716_4 Ribosomal protein S21 K02970 - - 0.00000000000000000000007741 101.0
HFD2_k127_6172716_5 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000002488 91.0
HFD2_k127_6183387_0 Peptidase family M1 domain - - - 9.521e-235 742.0
HFD2_k127_6183387_1 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001046 256.0
HFD2_k127_6183387_2 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide - - - 0.00009787 45.0
HFD2_k127_6185964_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.059e-205 655.0
HFD2_k127_6186006_0 HypF finger K04656 - - 8.953e-308 960.0
HFD2_k127_6186006_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 436.0
HFD2_k127_6186006_10 - - - - 0.000000000000000000000000000003601 133.0
HFD2_k127_6186006_11 Trm112p-like protein K09791 - - 0.00000000000000096 80.0
HFD2_k127_6186006_12 COG NOG15344 non supervised orthologous group - - - 0.000009069 47.0
HFD2_k127_6186006_13 - - - - 0.00005272 48.0
HFD2_k127_6186006_14 long-chain fatty acid transport protein - - - 0.0003892 52.0
HFD2_k127_6186006_2 Diguanylate cyclase, GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006241 336.0
HFD2_k127_6186006_3 Integral membrane protein TerC family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 316.0
HFD2_k127_6186006_4 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006894 319.0
HFD2_k127_6186006_5 PFAM Sodium calcium exchanger protein K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 301.0
HFD2_k127_6186006_6 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002821 282.0
HFD2_k127_6186006_7 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008869 273.0
HFD2_k127_6186006_8 COG NOG14600 non supervised orthologous group - - - 0.0000000000000000000000000000000000000000000000000000003518 196.0
HFD2_k127_6186006_9 - - - - 0.0000000000000000000000000000000000000000000001412 184.0
HFD2_k127_6189191_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 499.0
HFD2_k127_6189191_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006938 416.0
HFD2_k127_6189191_2 PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000003746 244.0
HFD2_k127_6189191_3 Surface antigen K07277,K07278 - - 0.00000000001335 74.0
HFD2_k127_6202118_0 WD40-like Beta Propeller Repeat - - - 8.209e-213 694.0
HFD2_k127_6205876_0 MacB-like periplasmic core domain - - - 3.646e-290 930.0
HFD2_k127_6205876_1 Peptidase family M1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006511 596.0
HFD2_k127_6205876_2 (ABC) transporter K06147,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007103 239.0
HFD2_k127_6205876_3 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000001266 208.0
HFD2_k127_6205876_4 Zinc carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000001137 183.0
HFD2_k127_6205876_5 Domain of unknown function (DUF1854) - - - 0.000000008372 63.0
HFD2_k127_6206718_0 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008048 528.0
HFD2_k127_6206718_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000001639 192.0
HFD2_k127_6217901_0 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 1.526e-252 795.0
HFD2_k127_6217901_1 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 586.0
HFD2_k127_6217901_2 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000000000000001301 168.0
HFD2_k127_6217901_3 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000008767 146.0
HFD2_k127_6217901_4 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.000000000000000000000002002 104.0
HFD2_k127_6217901_5 - - - - 0.0000000000000000000001376 111.0
HFD2_k127_6217901_6 subunit of a heme lyase K02200 - - 0.0000000000000000000002898 108.0
HFD2_k127_6219734_0 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 361.0
HFD2_k127_6219734_1 peptidase activity, acting on L-amino acid peptides K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005972 330.0
HFD2_k127_6219734_2 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001795 276.0
HFD2_k127_6219734_3 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004333 298.0
HFD2_k127_6219734_4 xylanase chitin deacetylase - - - 0.0000000000000000000000000000000000000000000006023 175.0
HFD2_k127_6219734_5 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000003796 154.0
HFD2_k127_6222393_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 7.193e-267 843.0
HFD2_k127_6222393_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002444 287.0
HFD2_k127_6222393_2 DNA-directed DNA polymerase activity K02347,K03581,K04477 - 3.1.11.5 0.0000000000000000000000001955 107.0
HFD2_k127_6223415_0 PFAM Formylglycine-generating sulfatase enzyme - - - 0.000000000000000000000000000000001454 141.0
HFD2_k127_6223415_1 - - - - 0.0000000000004097 76.0
HFD2_k127_6234819_0 DNA polymerase X family K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 586.0
HFD2_k127_6234819_1 - - - - 0.00000000000000000000000000000000000000000000000000000000468 209.0
HFD2_k127_6234819_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000002186 203.0
HFD2_k127_6234819_3 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000001447 156.0
HFD2_k127_6234819_4 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000001338 74.0
HFD2_k127_6234819_5 Carboxypeptidase regulatory-like domain - - - 0.0002881 46.0
HFD2_k127_6234887_0 Band 7 protein K07192 - - 0.0000000000000000000000000000000000000000000000000000000000001137 223.0
HFD2_k127_6234887_1 Disulphide isomerase - - - 0.0000000000000000000000000000000000000000000000008939 178.0
HFD2_k127_6236075_0 PFAM Beta-lactamase K18988 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 423.0
HFD2_k127_6236075_1 FES K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001942 268.0
HFD2_k127_6236075_2 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000002372 246.0
HFD2_k127_6236075_3 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000562 208.0
HFD2_k127_6236075_4 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.00000002699 63.0
HFD2_k127_6236075_5 Cbs domain - - - 0.0000003937 58.0
HFD2_k127_6272435_0 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003592 261.0
HFD2_k127_6272435_1 DNA-templated transcription, initiation - - - 0.00000000000000000000000000000000000000000000000002752 191.0
HFD2_k127_6272435_2 - - - - 0.000000000000002735 78.0
HFD2_k127_6272435_3 Belongs to the ompA family - - - 0.000000000155 67.0
HFD2_k127_6282807_0 Glucose inhibited division protein A K21401 - 1.3.99.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005584 294.0
HFD2_k127_6282807_1 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000002807 188.0
HFD2_k127_6282807_2 Integral membrane protein DUF92 - - - 0.000000000000000000000000000000000007331 147.0
HFD2_k127_6282807_3 PFAM flavin reductase domain protein, FMN-binding - - - 0.0000000000000000000000000000000002645 150.0
HFD2_k127_6282807_4 - - - - 0.0000000000000000000000000000000004779 138.0
HFD2_k127_6282807_5 Putative zinc-finger - - - 0.00000000000001797 77.0
HFD2_k127_6282807_6 PFAM Metallopeptidase family M24 K01262 - 3.4.11.9 0.00000004169 56.0
HFD2_k127_6282807_7 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000006605 54.0
HFD2_k127_6303097_0 Asparagine synthase K01953 - 6.3.5.4 4.064e-220 715.0
HFD2_k127_6303097_1 ATP binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003475 291.0
HFD2_k127_6307913_0 Phosphoglycerate kinase K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000465 505.0
HFD2_k127_6307913_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000001246 237.0
HFD2_k127_6307913_2 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000003018 184.0
HFD2_k127_6307913_3 Preprotein translocase SecG subunit K03075 - - 0.0000000002171 64.0
HFD2_k127_6316573_0 Capsule assembly protein Wzi - - - 0.00000000000000000005289 104.0
HFD2_k127_6316573_1 PFAM Amidohydrolase 2 K01686 - 4.2.1.8 0.000000000000000006792 96.0
HFD2_k127_6316573_2 amino acid activation for nonribosomal peptide biosynthetic process K06045 - 4.2.1.129,5.4.99.17 0.0007705 50.0
HFD2_k127_6318026_0 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000000000002245 214.0
HFD2_k127_6318026_1 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000005469 162.0
HFD2_k127_6318026_2 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000001529 156.0
HFD2_k127_6325308_0 DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004675 252.0
HFD2_k127_6325308_1 Histidine kinase K00936,K02030 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000004156 251.0
HFD2_k127_6325308_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000508 222.0
HFD2_k127_6325308_3 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000002772 51.0
HFD2_k127_6327419_0 (ABC) transporter K06147,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003689 486.0
HFD2_k127_6327530_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 5.102e-230 745.0
HFD2_k127_6327530_1 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 301.0
HFD2_k127_6327530_2 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000146 229.0
HFD2_k127_6327530_3 HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000002585 229.0
HFD2_k127_6327530_4 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000002176 195.0
HFD2_k127_6327530_5 Sporulation related domain K03749 - - 0.0002417 53.0
HFD2_k127_6335737_0 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 477.0
HFD2_k127_6335737_1 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002032 286.0
HFD2_k127_6335737_2 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.000000000000000000000000000000000000000000000000002767 188.0
HFD2_k127_6335737_3 hydrogenase 4 membrane K12140 - - 0.0000000000000000000000000000000000000000000000003672 194.0
HFD2_k127_6335737_4 PFAM NADH Ubiquinone plastoquinone (complex I) K12141 - - 0.000000000000000000000000000000001709 145.0
HFD2_k127_6348342_0 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 338.0
HFD2_k127_6348342_1 positive regulation of growth rate - - - 0.0000000000001207 83.0
HFD2_k127_6363540_0 Cytochrome b/b6/petB K00412,K03888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009022 349.0
HFD2_k127_6363540_1 Rieske [2Fe-2S] domain K02636,K03886 - 1.10.9.1 0.0000000000000000000000000000000006117 137.0
HFD2_k127_6363540_2 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000001452 120.0
HFD2_k127_6363540_3 - - - - 0.000000724 61.0
HFD2_k127_6363540_4 Iron permease FTR1 family K07243 - - 0.0000007764 55.0
HFD2_k127_6363540_5 PFAM cytochrome - - - 0.00005329 50.0
HFD2_k127_6371055_0 cobalamin-transporting ATPase activity K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001491 253.0
HFD2_k127_6371055_1 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000009091 84.0
HFD2_k127_6371055_2 Translation elongation factor K03833 - - 0.00000001172 63.0
HFD2_k127_6389680_0 curli production assembly transport component CsgG K04087 - - 0.000000000000000000000000000000000000000000008323 183.0
HFD2_k127_6389680_1 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.000000000000002608 76.0
HFD2_k127_6389680_2 - - - - 0.00000000001109 74.0
HFD2_k127_6391870_0 Acetamidase/Formamidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 389.0
HFD2_k127_6391870_1 beta-lactamase - - - 0.00000000000000000000000000000000000001407 151.0
HFD2_k127_6391870_2 general secretion pathway protein G K02456 - - 0.00005682 53.0
HFD2_k127_6400451_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 415.0
HFD2_k127_6400451_1 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002122 244.0
HFD2_k127_6400451_2 PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000002873 246.0
HFD2_k127_6400451_3 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000001868 201.0
HFD2_k127_6400451_4 diguanylate cyclase - - - 0.00000000000000000000000000000001181 147.0
HFD2_k127_6400451_5 PFAM S23 ribosomal protein - - - 0.00000000000002505 78.0
HFD2_k127_6417233_0 - - - - 0.00000000000000000000000000000000000000000000000000008146 203.0
HFD2_k127_6417233_1 PFAM peptidase M55 D-aminopeptidase K16203 - - 0.000000000000000000000000000000000009867 149.0
HFD2_k127_6417233_2 D-aminopeptidase K16203 - - 0.00000000000000000000000001259 121.0
HFD2_k127_6430955_0 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000000000000005673 192.0
HFD2_k127_6430955_1 1,4-alpha-glucan branching enzyme activity K00700 - 2.4.1.18 0.0000000000000000000000009509 109.0
HFD2_k127_6430955_2 Domain of unknown function (DUF4382) - - - 0.000000000005106 77.0
HFD2_k127_6442111_0 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 427.0
HFD2_k127_6442111_1 secreted acid phosphatase - - - 0.000000000000000000000159 109.0
HFD2_k127_6443078_0 C-terminus of AA_permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 404.0
HFD2_k127_6443078_1 PFAM Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 324.0
HFD2_k127_6443078_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003462 291.0
HFD2_k127_6443078_3 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000002 207.0
HFD2_k127_6443078_4 Copper amine oxidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000002532 204.0
HFD2_k127_6443704_0 Protein kinase domain K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000001157 250.0
HFD2_k127_6443704_1 peptidyl-tyrosine sulfation - - - 0.00000000000000006612 96.0
HFD2_k127_6444964_0 Transglycosylase SLT domain K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003933 289.0
HFD2_k127_6444964_1 Transglycosylase SLT domain - - - 0.00000000002138 66.0
HFD2_k127_6444964_2 - - - - 0.000000000317 64.0
HFD2_k127_6469829_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1091.0
HFD2_k127_6469829_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 2.948e-226 729.0
HFD2_k127_6469829_2 Transketolase, pyrimidine binding domain K00167,K11381,K21417 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004562 501.0
HFD2_k127_6469829_3 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009031 428.0
HFD2_k127_6469829_4 Cupredoxin-like domain - - - 0.0000000000000000000000000000005247 128.0
HFD2_k127_6469829_5 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.00000000000000000000000000505 110.0
HFD2_k127_6469829_6 - - - - 0.0000000000000000002024 92.0
HFD2_k127_6469829_7 Heavy metal transport detoxification protein - - - 0.000000003622 69.0
HFD2_k127_6473910_0 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 3.004e-219 691.0
HFD2_k127_6473910_1 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.0000000000000000000000000000000000000000000000004617 177.0
HFD2_k127_6478366_0 Histidine Phosphotransfer domain K03413,K07662,K07667,K11443 - - 0.00000000000000000000000000000000000000000000000000007116 211.0
HFD2_k127_6478366_1 histidine kinase A domain protein domain protein - - - 0.000000000000000000000000000000000302 152.0
HFD2_k127_6478366_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000001888 139.0
HFD2_k127_6497019_0 efflux transmembrane transporter activity K02004 - - 2.476e-201 654.0
HFD2_k127_6497019_1 FtsX-like permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 377.0
HFD2_k127_65050_0 Involved in the tonB-independent uptake of proteins K03641,K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000001628 248.0
HFD2_k127_65050_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000004024 179.0
HFD2_k127_65050_2 DNA-templated transcription, initiation - - - 0.000000000000000000000000000000000000000000000634 182.0
HFD2_k127_65050_3 Uncharacterized protein conserved in bacteria (DUF2062) - - - 0.0000000000000000002486 92.0
HFD2_k127_65050_4 Protein involved in outer membrane biogenesis - - - 0.00000000000000002776 96.0
HFD2_k127_6543988_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1014.0
HFD2_k127_654491_0 Hypothetical methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000009874 219.0
HFD2_k127_654491_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K15975 - - 0.00000000000000000000000000000000000000000000042 177.0
HFD2_k127_654491_2 synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000005212 162.0
HFD2_k127_6565189_0 Type I phosphodiesterase / nucleotide pyrophosphatase K01113 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 431.0
HFD2_k127_6565189_1 40-residue YVTN family beta-propeller repeat - - - 0.00000000000004822 76.0
HFD2_k127_6581864_0 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 565.0
HFD2_k127_6581864_1 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 468.0
HFD2_k127_6601678_0 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000007115 224.0
HFD2_k127_6626358_0 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052,K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007002 361.0
HFD2_k127_6626358_1 LysM domain K08307,K12204 - - 0.000000000000000000000000000001782 131.0
HFD2_k127_6629857_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 5.307e-266 836.0
HFD2_k127_6629857_1 DAHP synthetase I family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006169 347.0
HFD2_k127_6629857_2 Peptidase C26 K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000001866 249.0
HFD2_k127_6629857_3 SIS domain K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000004734 220.0
HFD2_k127_6629857_4 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000003231 219.0
HFD2_k127_6629857_5 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000000001762 180.0
HFD2_k127_6629857_6 Transglycosylase associated protein - - - 0.00000000000000002526 82.0
HFD2_k127_6629857_7 - - - - 0.000002323 57.0
HFD2_k127_6694446_0 Ribosomal protein S2 K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 361.0
HFD2_k127_6694446_1 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 323.0
HFD2_k127_6694446_2 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 313.0
HFD2_k127_6694446_3 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000000004079 226.0
HFD2_k127_6694446_4 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000004706 213.0
HFD2_k127_6694446_5 Ribosomal protein S9/S16 K02996 - - 0.00000000000000000000000000000000000000000000000000005455 189.0
HFD2_k127_6712059_0 5TM C-terminal transporter carbon starvation CstA K06200 - - 2.715e-211 666.0
HFD2_k127_6712059_1 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000002093 219.0
HFD2_k127_6770268_0 response regulator K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 393.0
HFD2_k127_6770268_1 pilus assembly protein PilW - - - 0.0000009178 61.0
HFD2_k127_6770268_2 Type II secretion system (T2SS), protein G K02456 - - 0.0003206 49.0
HFD2_k127_6817937_0 3-isopropylmalate dehydratase activity K01681,K01703,K01704,K17749 - 4.2.1.3,4.2.1.33,4.2.1.35 9.76e-244 770.0
HFD2_k127_6817937_1 pilus organization K07004 - - 0.00000000000000000000000000000000000002822 166.0
HFD2_k127_6817937_2 - - - - 0.000000000000000000000000000000001634 141.0
HFD2_k127_6829082_0 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002862 349.0
HFD2_k127_6829082_1 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 - 5.4.2.8 0.000000000000000000000000000000000000000000000000000001533 196.0
HFD2_k127_6829082_2 Cys/Met metabolism PLP-dependent enzyme K01758 - 4.4.1.1 0.000000000002801 68.0
HFD2_k127_7018095_0 secondary active sulfate transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 494.0
HFD2_k127_7018095_1 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007485 439.0
HFD2_k127_7018095_2 aminopeptidase K01256 - 3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 372.0
HFD2_k127_7020051_0 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 491.0
HFD2_k127_7020051_1 O-acyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004882 263.0
HFD2_k127_7020051_2 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001509 255.0
HFD2_k127_7020051_3 Helix-hairpin-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000000002636 232.0
HFD2_k127_7020051_4 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000005764 156.0
HFD2_k127_7020051_5 Dodecin K09165 - - 0.0000000000000000003396 95.0
HFD2_k127_7020051_6 PFAM CBS domain containing protein - - - 0.000000000000347 79.0
HFD2_k127_7020051_7 Belongs to the universal stress protein A family - - - 0.00000000001829 75.0
HFD2_k127_7020051_8 PFAM CBS domain containing protein K07182 - - 0.000000004551 68.0
HFD2_k127_7020051_9 Universal stress protein family - - - 0.000007937 57.0
HFD2_k127_7029213_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006568 393.0
HFD2_k127_7029213_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004232 340.0
HFD2_k127_7029213_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007077 284.0
HFD2_k127_7029213_3 Acyl transferase domain K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000003458 235.0
HFD2_k127_7029213_4 NDK K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000003843 177.0
HFD2_k127_7029213_5 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000000000000000000000001159 153.0
HFD2_k127_7029213_6 Ribosomal L32p protein family K02911 - - 0.000000000000000000005923 93.0
HFD2_k127_7031364_0 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006071 259.0
HFD2_k127_7031364_1 Glycine zipper - - - 0.00000000000000000000000000000000000000000000000000000000000009874 219.0
HFD2_k127_7031364_2 - - - - 0.0000000000002988 75.0
HFD2_k127_7034302_0 CarboxypepD_reg-like domain - - - 6.343e-290 928.0
HFD2_k127_7034302_1 CarboxypepD_reg-like domain - - - 1.532e-239 779.0
HFD2_k127_7034302_2 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 389.0
HFD2_k127_7034302_3 Pfam:SusD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005385 394.0
HFD2_k127_7034302_4 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000000000000000008785 155.0
HFD2_k127_7034302_5 Domain of unknown function (DUF4397) - - - 0.000000000000000000000000000000005182 139.0
HFD2_k127_7034302_6 transport - - - 0.00000000000000000000000000000001193 136.0
HFD2_k127_7034302_7 PFAM DSBA oxidoreductase - - - 0.00000000000000000000000000000442 127.0
HFD2_k127_7034302_8 transport - - - 0.0000000000000000000001098 107.0
HFD2_k127_7034302_9 - - - - 0.0000000000001215 82.0
HFD2_k127_7040461_0 Biotin-lipoyl like K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 409.0
HFD2_k127_7040461_1 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001001 267.0
HFD2_k127_7040461_2 creatininase K01470,K22232 - 3.5.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000287 246.0
HFD2_k127_7040461_3 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000001365 87.0
HFD2_k127_7041497_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004452 554.0
HFD2_k127_7041497_1 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000003659 259.0
HFD2_k127_7041497_2 IMP dehydrogenase activity K07182 - - 0.000000000007915 72.0
HFD2_k127_7041497_3 Archease protein family (MTH1598/TM1083) - - - 0.000000006475 63.0
HFD2_k127_7048259_0 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 429.0
HFD2_k127_7048259_1 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 363.0
HFD2_k127_7048259_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000001743 200.0
HFD2_k127_7048259_3 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000001105 201.0
HFD2_k127_7048259_4 - - - - 0.000003131 60.0
HFD2_k127_7048259_5 Putative stress-induced transcription regulator - - - 0.000004853 51.0
HFD2_k127_70508_0 Malate synthase K01638 - 2.3.3.9 1.298e-230 725.0
HFD2_k127_70508_1 Isocitrate lyase K01637 - 4.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 594.0
HFD2_k127_70508_2 protein secretion by the type I secretion system K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004031 249.0
HFD2_k127_7059343_0 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005548 462.0
HFD2_k127_7060177_0 amino acid K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 342.0
HFD2_k127_7060177_1 AI-2E family transporter - - - 0.000000000000000000000000000000000007367 141.0
HFD2_k127_7060177_2 PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - 0.0000002191 60.0
HFD2_k127_7060177_3 PFAM Hemolysin-type calcium-binding repeat (2 copies) - - - 0.0005888 50.0
HFD2_k127_7064963_0 aconitate hydratase K01681 - 4.2.1.3 1.18e-198 626.0
HFD2_k127_7064963_1 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000001857 192.0
HFD2_k127_7064963_2 - - - - 0.0000000000000000000000000000000000000000001522 162.0
HFD2_k127_7064963_3 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000007529 159.0
HFD2_k127_7064963_4 ArsC family - - - 0.0000000000000000000000000000000004175 133.0
HFD2_k127_7064963_5 Thioesterase superfamily - - - 0.0000000000000000000000000000003513 131.0
HFD2_k127_7065765_0 Nicastrin K01301 - 3.4.17.21 1.39e-231 740.0
HFD2_k127_7065765_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007928 473.0
HFD2_k127_7065765_2 amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 464.0
HFD2_k127_7065765_3 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 424.0
HFD2_k127_7065765_4 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000009883 248.0
HFD2_k127_7065765_5 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000001854 237.0
HFD2_k127_7065765_6 - - - - 0.00002038 50.0
HFD2_k127_7070435_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.038e-196 621.0
HFD2_k127_7070435_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006879 254.0
HFD2_k127_7070575_0 heat shock protein binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002136 265.0
HFD2_k127_7070575_1 heat shock protein binding - - - 0.000000000000000000000000000000000000002827 156.0
HFD2_k127_7077069_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 333.0
HFD2_k127_7077069_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006395 273.0
HFD2_k127_7077069_2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000008872 198.0
HFD2_k127_7077069_3 phosphorelay signal transduction system K07713 - - 0.000000000000000000000008226 115.0
HFD2_k127_7089585_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.059e-226 713.0
HFD2_k127_7089585_1 Pyridoxal phosphate biosynthetic protein PdxA K00097 - 1.1.1.262 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 333.0
HFD2_k127_7089585_2 SurA N-terminal domain K03771 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000001056 273.0
HFD2_k127_7089585_3 PPIC-type PPIASE domain K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000001724 236.0
HFD2_k127_7097009_0 major facilitator K16211 - - 1.065e-205 652.0
HFD2_k127_7097009_1 Alpha-amylase domain K01176 - 3.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 355.0
HFD2_k127_7097009_2 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007809 280.0
HFD2_k127_7101334_0 isocitrate dehydrogenase activity K00031 GO:0003674,GO:0003824,GO:0003862,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007735 538.0
HFD2_k127_7101334_1 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 439.0
HFD2_k127_7101334_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 439.0
HFD2_k127_7101334_3 Fibronectin type 3 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 327.0
HFD2_k127_7102172_0 Small subunit K06282 - 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 436.0
HFD2_k127_7102172_1 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 - 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000859 387.0
HFD2_k127_7102172_2 PFAM V-type ATPase 116 kDa K02123 - - 0.0000000001571 72.0
HFD2_k127_7108528_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.00000000000000000000000000000000000000000000000000000000000239 215.0
HFD2_k127_7108528_1 Pyrimidine nucleoside phosphorylase C-terminal domain K00756 - 2.4.2.2 0.000000000000000000000000000000000000001319 150.0
HFD2_k127_7108528_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000005943 139.0
HFD2_k127_7108528_3 Phosphodiesterase 11A K13298 GO:0000166,GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0004118,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005829,GO:0006091,GO:0006119,GO:0006122,GO:0006123,GO:0006139,GO:0006163,GO:0006195,GO:0006198,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007186,GO:0008081,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009154,GO:0009161,GO:0009166,GO:0009167,GO:0009187,GO:0009199,GO:0009205,GO:0009214,GO:0009259,GO:0009261,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0010604,GO:0010646,GO:0010648,GO:0010752,GO:0010754,GO:0010941,GO:0010942,GO:0010950,GO:0010952,GO:0015980,GO:0016310,GO:0016787,GO:0016788,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019222,GO:0019438,GO:0019439,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0023051,GO:0023052,GO:0023057,GO:0030162,GO:0030551,GO:0030552,GO:0030553,GO:0030554,GO:0031323,GO:0031325,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0032268,GO:0032270,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0036477,GO:0042578,GO:0042773,GO:0042775,GO:0042981,GO:0043025,GO:0043065,GO:0043067,GO:0043068,GO:0043085,GO:0043167,GO:0043168,GO:0043204,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043280,GO:0043281,GO:0043949,GO:0043951,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044297,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0045862,GO:0046034,GO:0046058,GO:0046068,GO:0046069,GO:0046434,GO:0046483,GO:0046700,GO:0047555,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0051716,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0065007,GO:0065009,GO:0070013,GO:0071704,GO:0072521,GO:0072523,GO:0080090,GO:0097159,GO:0097367,GO:0097458,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1902531,GO:1902532,GO:2000116,GO:2001056 3.1.4.17,3.1.4.35 0.0005265 51.0
HFD2_k127_7115110_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 342.0
HFD2_k127_7115110_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 335.0
HFD2_k127_7115303_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004733 321.0
HFD2_k127_7115303_1 Aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 291.0
HFD2_k127_7119699_0 Glycosyl hydrolase family 3 C-terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000954 406.0
HFD2_k127_7119699_1 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 317.0
HFD2_k127_7119699_2 Protein of unknown function (DUF1343) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001348 252.0
HFD2_k127_7119699_3 Iron-sulphur cluster biosynthesis - - - 0.00000000000000000000000000000000000003308 149.0
HFD2_k127_7119699_4 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.00000000000000000000000000000000002452 138.0
HFD2_k127_7121168_0 histidine kinase A domain protein K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 313.0
HFD2_k127_7121168_1 - - - - 0.000000000000000000000000000001692 132.0
HFD2_k127_7121168_2 response regulator, receiver - - - 0.00000000000000000000000000001762 121.0
HFD2_k127_7121168_3 NUDIX domain K08310 - 3.6.1.67 0.00000000000000000000000000005278 127.0
HFD2_k127_7121168_4 enzyme binding K00567,K07443 - 2.1.1.63 0.00000000000000000000004361 104.0
HFD2_k127_7121168_5 transferase activity, transferring glycosyl groups - - - 0.000000004323 61.0
HFD2_k127_7121453_0 4Fe-4S dicluster domain K00184 - - 3.048e-235 762.0
HFD2_k127_7121453_1 carboxylic acid catabolic process K02549 GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.2.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000003268 272.0
HFD2_k127_7121453_2 dihydroorotate dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000009409 241.0
HFD2_k127_7121453_3 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000001924 142.0
HFD2_k127_7121453_4 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000003964 93.0
HFD2_k127_7126115_0 Exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 563.0
HFD2_k127_7126115_1 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000032 377.0
HFD2_k127_7126115_2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009665 275.0
HFD2_k127_7126115_3 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005799 251.0
HFD2_k127_7126115_4 Dienelactone hydrolase family K07100 - - 0.0000000000000000000000000000000000000000000000000000000000000003198 228.0
HFD2_k127_7126115_5 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760,K04075,K15780 GO:0003674,GO:0003824,GO:0004422,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0052657,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.8,6.3.4.19 0.00000000000000000000000000000000000000000000000000000009394 200.0
HFD2_k127_7126115_6 L,D-transpeptidase catalytic domain K21470 - - 0.0000000000000001061 89.0
HFD2_k127_7126115_7 Belongs to the universal stress protein A family - - - 0.000000000001579 78.0
HFD2_k127_7126669_0 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005986 477.0
HFD2_k127_7126669_1 Amidohydrolase family K01466 - 3.5.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 457.0
HFD2_k127_7126669_2 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003448 433.0
HFD2_k127_7126669_3 DinB family - - - 0.0004458 49.0
HFD2_k127_7147290_0 efflux transmembrane transporter activity - - - 1.436e-223 722.0
HFD2_k127_7147290_1 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 3.181e-208 670.0
HFD2_k127_7147290_2 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 483.0
HFD2_k127_7147290_3 nucleotidyltransferase activity - - - 0.000000000000000000000000000000000000000692 152.0
HFD2_k127_7147290_4 negative regulation of transcription, DNA-templated - - - 0.000000000000000000000000000000000000004076 149.0
HFD2_k127_7147290_5 Transglycosylase associated protein - - - 0.0000000000000000000000001515 109.0
HFD2_k127_7157754_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 377.0
HFD2_k127_7157754_1 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000000000007828 135.0
HFD2_k127_7157754_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000001904 65.0
HFD2_k127_7170708_0 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 493.0
HFD2_k127_7170708_1 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001487 272.0
HFD2_k127_7170708_2 Amidohydrolase family - - - 0.0003189 45.0
HFD2_k127_7175651_0 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006871 357.0
HFD2_k127_7175651_1 Putative porin - - - 0.00000000000000000000000000000001136 130.0
HFD2_k127_7175651_2 cell redox homeostasis - - - 0.000000000000000001807 100.0
HFD2_k127_7175651_3 Putative beta-lactamase-inhibitor-like, PepSY-like - - - 0.0000000000000008325 88.0
HFD2_k127_7175651_5 SnoaL-like domain - - - 0.000000007269 64.0
HFD2_k127_7177662_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000004803 98.0
HFD2_k127_7177662_1 creatininase K01470,K22232 - 3.5.2.10 0.00000000001302 78.0
HFD2_k127_7188502_0 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 496.0
HFD2_k127_7188502_1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002443 269.0
HFD2_k127_7188502_2 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000004771 176.0
HFD2_k127_7188502_3 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.00000000000000001239 88.0
HFD2_k127_7189653_0 Aminotransferase class I and II K10907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 473.0
HFD2_k127_7189653_1 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003782 407.0
HFD2_k127_7189653_2 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.000000000000000000000000000000000000000000000000000002912 211.0
HFD2_k127_7189653_3 Fibronectin type 3 domain - - - 0.000000000000000000000000000000000000000000004036 186.0
HFD2_k127_7189653_4 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000001708 91.0
HFD2_k127_7190244_0 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 8.433e-205 651.0
HFD2_k127_7190244_1 MatE K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006341 393.0
HFD2_k127_7190244_2 Cache domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001659 292.0
HFD2_k127_7190244_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000002054 243.0
HFD2_k127_7190244_4 PFAM SH3, type 3 - - - 0.0000000000000494 82.0
HFD2_k127_7196896_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 6.574e-319 994.0
HFD2_k127_7196896_1 Binding-protein-dependent transport system inner membrane component K02011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 410.0
HFD2_k127_7196896_2 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 346.0
HFD2_k127_7196896_3 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009009 306.0
HFD2_k127_7196896_4 Belongs to the ABC transporter superfamily K02010,K02052 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000006007 274.0
HFD2_k127_7196896_5 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00124 - - 0.00000000000000000000000000000000000000000000000000000000000000003965 232.0
HFD2_k127_7196896_6 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000005133 197.0
HFD2_k127_7196896_7 Prokaryotic cytochrome b561 - - - 0.00000000000000000000001783 112.0
HFD2_k127_7196896_8 Necessary for formate dehydrogenase activity K02380 - - 0.000000000000000000009671 106.0
HFD2_k127_7198495_0 Cytochrome C assembly protein K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000001145 234.0
HFD2_k127_7198495_1 CcmB protein K02194 - - 0.000000000000000000000000000000000000000000000000000000005204 208.0
HFD2_k127_7198495_2 water channel activity K02440,K06188,K09874 - - 0.000000000000000000000000000000000000000000000000000003904 198.0
HFD2_k127_7198495_3 AAA domain, putative AbiEii toxin, Type IV TA system K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000323 166.0
HFD2_k127_7198495_4 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.000000000000000000000005805 103.0
HFD2_k127_7198495_5 response regulator K02483 - - 0.0000000000000003079 86.0
HFD2_k127_7200735_0 penicillin binding K05367 - 2.4.1.129 4.882e-264 847.0
HFD2_k127_7200735_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 370.0
HFD2_k127_7200735_2 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000816 215.0
HFD2_k127_7200735_3 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines - - - 0.00000000008467 65.0
HFD2_k127_7204060_0 Aminotransferase class-III K00822 - 2.6.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 612.0
HFD2_k127_7204060_1 Peptidase family M20/M25/M40 - - - 0.0000000000000000000002012 101.0
HFD2_k127_7213390_0 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008167 421.0
HFD2_k127_7213390_1 Glycosyltransferase like family 2 K20534 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 334.0
HFD2_k127_7213390_2 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000677 189.0
HFD2_k127_7213390_4 methyltransferase activity - - - 0.0000000000000188 87.0
HFD2_k127_7213390_6 Small integral membrane protein 24 - - - 0.00006941 51.0
HFD2_k127_7213390_7 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000109 55.0
HFD2_k127_7213390_8 COG1910 Periplasmic molybdate-binding protein domain - - - 0.0003791 49.0
HFD2_k127_72164_0 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 307.0
HFD2_k127_72164_1 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009508 294.0
HFD2_k127_7217771_0 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009098 340.0
HFD2_k127_7217771_1 GAF domain-containing protein K08968 - 1.8.4.14 0.0000000000000000000000000277 115.0
HFD2_k127_7217771_2 Putative zinc ribbon domain - - - 0.000000000000411 72.0
HFD2_k127_7217771_3 phosphorelay sensor kinase activity K16923 - - 0.00002766 52.0
HFD2_k127_7226729_0 serine-type peptidase activity K08676 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 5.136e-238 749.0
HFD2_k127_7226729_1 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000007291 226.0
HFD2_k127_7239223_0 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.0000000000000000000000000000000000000000001334 172.0
HFD2_k127_7239223_1 PFAM CoA-binding domain protein K06929 - - 0.000000000000000000000000000000002519 136.0
HFD2_k127_7239223_2 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000006686 134.0
HFD2_k127_7239223_3 PFAM binding-protein-dependent transport systems inner membrane component K05773,K06857 - 3.6.3.55 0.000000000000000000001015 96.0
HFD2_k127_7239223_4 6-pyruvoyl tetrahydrobiopterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000009953 100.0
HFD2_k127_72557_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 619.0
HFD2_k127_72557_1 RibD C-terminal domain - - - 0.0000000000000000000000001525 110.0
HFD2_k127_7258422_0 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 358.0
HFD2_k127_7258422_1 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000005794 156.0
HFD2_k127_7260910_0 Zinc carboxypeptidase - - - 2.519e-235 754.0
HFD2_k127_7260910_1 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 321.0
HFD2_k127_7260910_2 Putative glycosyl hydrolase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001407 265.0
HFD2_k127_7260910_3 Thrombospondin type 3 repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000001318 235.0
HFD2_k127_7277261_0 Thrombospondin type 3 repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000003313 236.0
HFD2_k127_7277261_1 Thrombospondin type 3 repeat - - - 0.00000000000000000000000000000000000000000000000000000000000001724 232.0
HFD2_k127_7291822_0 Aldo/keto reductase family K05275 - 1.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 484.0
HFD2_k127_7291822_1 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000000000000000000001764 221.0
HFD2_k127_7291822_2 Putative zinc-finger - - - 0.00000000000000000000000000000000000000000000000000001491 205.0
HFD2_k127_7291822_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000006278 187.0
HFD2_k127_7291822_4 NADPH quinone reductase K00344 - 1.6.5.5 0.0000000000000000000001302 105.0
HFD2_k127_7306563_0 HNH nucleases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 295.0
HFD2_k127_7306563_1 - - - - 0.0000000000000000000000000000000000000000000000000006152 195.0
HFD2_k127_7306563_2 - - - - 0.00000000000000000001019 106.0
HFD2_k127_7306563_4 Argininosuccinate lyase K01755 GO:0000050,GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000007971 50.0
HFD2_k127_7310499_0 Sugar (and other) transporter K03446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 593.0
HFD2_k127_7310499_1 PFAM metallophosphoesterase K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000418 330.0
HFD2_k127_7310499_2 Biotin-lipoyl like K03543 - - 0.0000000000000000000000000000000000000000000000000000000000009678 218.0
HFD2_k127_7310499_3 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000004813 188.0
HFD2_k127_7310499_4 Cupin 2, conserved barrel - - - 0.000000000000000000000000000000000000000000003253 177.0
HFD2_k127_7310499_5 glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.00000000000000000000000000004711 117.0
HFD2_k127_7314824_0 Zinc carboxypeptidase - - - 0.0 1030.0
HFD2_k127_7314824_1 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000001308 183.0
HFD2_k127_7314824_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000003279 85.0
HFD2_k127_7314824_3 MacB-like periplasmic core domain - - - 0.0000000001614 62.0
HFD2_k127_7323490_0 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005455 391.0
HFD2_k127_7323490_1 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.0000000000000003054 79.0
HFD2_k127_7323490_2 Membrane - - - 0.000003198 58.0
HFD2_k127_7324751_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005105 537.0
HFD2_k127_7326105_0 ferredoxin oxidoreductase, subunit alpha K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 376.0
HFD2_k127_7326105_1 PFAM thiamine pyrophosphate enzyme K00175 - 1.2.7.11,1.2.7.3 0.0000000000005482 72.0
HFD2_k127_7326105_2 4Fe-4S dicluster domain K00176 - 1.2.7.3 0.000000000002869 72.0
HFD2_k127_7326105_3 Pyridine nucleotide-disulphide oxidoreductase K00266,K00528,K17722 - 1.18.1.2,1.19.1.1,1.3.1.1,1.4.1.13,1.4.1.14 0.000000001024 60.0
HFD2_k127_7332469_0 Ankyrin repeats (3 copies) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 568.0
HFD2_k127_7332469_1 Bacterial regulatory proteins, tetR family - - - 0.0000001005 55.0
HFD2_k127_7342716_0 cyclopropane-fatty-acyl-phospholipid synthase K00574,K20238 - 2.1.1.317,2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 459.0
HFD2_k127_7342716_1 fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000001088 227.0
HFD2_k127_7342716_2 peptidase dimerisation domain protein - - - 0.000000000000001411 82.0
HFD2_k127_7359510_0 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000000000000000005141 235.0
HFD2_k127_7359510_1 TonB-dependent Receptor Plug Domain - - - 0.000000000005783 78.0
HFD2_k127_7360708_0 Leishmanolysin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001331 268.0
HFD2_k127_7370880_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000003493 254.0
HFD2_k127_7370880_1 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.000000000000000000000000000000000000000000000000000000003192 213.0
HFD2_k127_7370880_2 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000121 198.0
HFD2_k127_7376319_0 Prolyl oligopeptidase family K01303 - 3.4.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 558.0
HFD2_k127_7376319_1 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 368.0
HFD2_k127_7376319_2 DinB superfamily - - - 0.0000000000000000000000000000000000000006855 155.0
HFD2_k127_7381138_0 Histidine kinase K02482 - 2.7.13.3 0.0000000000000000000000064 115.0
HFD2_k127_7381138_1 Peptidase family M28 - - - 0.00000000000000000000002857 106.0
HFD2_k127_7381138_2 Inverse autotransporter, beta-domain K13735 - - 0.00008324 55.0
HFD2_k127_7393853_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 401.0
HFD2_k127_7393853_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 309.0
HFD2_k127_7393853_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005327 278.0
HFD2_k127_7393853_3 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000002789 147.0
HFD2_k127_7393853_4 HD superfamily hydrolase involved in NAD metabolism K00950 - 2.7.6.3 0.0000000000000000000000000000000004839 150.0
HFD2_k127_7402382_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 4.642e-239 758.0
HFD2_k127_7402382_1 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 317.0
HFD2_k127_7402382_2 - - - - 0.000000000000000007981 87.0
HFD2_k127_74035_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 435.0
HFD2_k127_74035_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004153 295.0
HFD2_k127_7424917_0 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001543 295.0
HFD2_k127_7430097_0 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 574.0
HFD2_k127_7430097_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006053 531.0
HFD2_k127_7430097_10 Phosphoribosyl transferase domain - - - 0.0000000000000000000000000000000002065 145.0
HFD2_k127_7430097_11 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits - - - 0.000000000000000008292 85.0
HFD2_k127_7430097_2 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 365.0
HFD2_k127_7430097_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005855 363.0
HFD2_k127_7430097_4 Telomere recombination K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000002226 206.0
HFD2_k127_7430097_5 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000003586 198.0
HFD2_k127_7430097_6 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000006331 185.0
HFD2_k127_7430097_7 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.000000000000000000000000000000000000000000000001585 183.0
HFD2_k127_7430097_8 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.00000000000000000000000000000000000000005096 166.0
HFD2_k127_7430097_9 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000008469 164.0
HFD2_k127_7433348_0 Chain length determinant protein K16554 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 492.0
HFD2_k127_7433348_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 381.0
HFD2_k127_7433363_0 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002813 410.0
HFD2_k127_7433363_1 Domain of unknown function (DUF4442) - - - 0.0000000000000000000000000000000000000003798 153.0
HFD2_k127_7436420_0 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004038 441.0
HFD2_k127_7436420_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000005028 208.0
HFD2_k127_7436420_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000002412 194.0
HFD2_k127_7436420_3 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000002074 158.0
HFD2_k127_7436420_4 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - 0.0000000000000000000000000003586 126.0
HFD2_k127_7470340_0 DEAD DEAH box helicase K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 486.0
HFD2_k127_7470340_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000003353 222.0
HFD2_k127_7470340_2 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000002006 180.0
HFD2_k127_7518403_0 Helix-hairpin-helix motif K02337 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001789 281.0
HFD2_k127_7518403_1 Sodium/hydrogen exchanger family - - - 0.000000000000000002958 98.0
HFD2_k127_7534_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001199 280.0
HFD2_k127_7534_1 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000001781 245.0
HFD2_k127_7534_2 Protein of unknown function (DUF721) - - - 0.000000000000000001022 90.0
HFD2_k127_75659_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 472.0
HFD2_k127_75659_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 463.0
HFD2_k127_75659_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 403.0
HFD2_k127_75659_3 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 380.0
HFD2_k127_75659_4 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000001068 195.0
HFD2_k127_75659_5 BioY family K03523 - - 0.0000000000000000000000000000000006363 137.0
HFD2_k127_75659_6 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000002928 123.0
HFD2_k127_75659_7 CAAX protease self-immunity K07052 - - 0.000000000000000000000000001052 124.0
HFD2_k127_7618418_0 Trypsin K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003181 355.0
HFD2_k127_7618418_1 Belongs to the MSOX MTOX family. MTOX subfamily K02846 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016647,GO:0033554,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050131,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0097159,GO:1901265,GO:1901363 - 0.00002507 46.0
HFD2_k127_762093_0 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 512.0
HFD2_k127_762093_1 peptidase S9B dipeptidylpeptidase IV domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000008381 216.0
HFD2_k127_7630856_0 Radical SAM superfamily K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 464.0
HFD2_k127_7630856_1 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000001266 195.0
HFD2_k127_7630856_2 Matrixin - - - 0.000000000000000000000000000000000005731 147.0
HFD2_k127_7657447_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 372.0
HFD2_k127_7657447_1 - - - - 0.00000000000000000000000000000000005807 136.0
HFD2_k127_7657447_2 - - - - 0.00000000002168 71.0
HFD2_k127_7714379_0 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 358.0
HFD2_k127_7714379_1 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001496 276.0
HFD2_k127_7714379_2 LemA family K03744 - - 0.000000000000000000000000000000000000000000000001178 188.0
HFD2_k127_7714379_3 MerR HTH family regulatory protein - - - 0.00000000000000000000000000000000001977 148.0
HFD2_k127_7714379_4 - - - - 0.00000000000000000000000000002032 126.0
HFD2_k127_7714379_5 general secretion pathway protein K02457 - - 0.000006934 53.0
HFD2_k127_7798474_0 associated with various cellular activities K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 324.0
HFD2_k127_7798474_1 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.00000000000000000000000000000001624 142.0
HFD2_k127_7798474_2 Domain of unknown function (DUF4350) - - - 0.0000009629 57.0
HFD2_k127_7891005_0 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 393.0
HFD2_k127_7891005_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.000000000000000000000000000000000000000000000000000001161 193.0
HFD2_k127_7891005_2 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000000000000007167 181.0
HFD2_k127_7891005_3 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - 0.000000000000000000000000000000000000000000000000313 183.0
HFD2_k127_7893709_0 Methylmalonyl-CoA mutase K01848,K11942 - 5.4.99.13,5.4.99.2 1.219e-259 811.0
HFD2_k127_7893709_1 Carboxyl transferase domain - - - 3.877e-236 751.0
HFD2_k127_7893709_2 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008829 366.0
HFD2_k127_7893709_3 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001667 271.0
HFD2_k127_7893709_4 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000007913 228.0
HFD2_k127_7893709_5 translation release factor activity K03265 GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.000000000000000000000000000000000000000673 167.0
HFD2_k127_7893709_6 Transporter associated domain K03699 - - 0.00000000000000000000000000001519 133.0
HFD2_k127_7894058_0 Cys/Met metabolism PLP-dependent enzyme K01758 - 4.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 527.0
HFD2_k127_7894058_1 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 347.0
HFD2_k127_7894058_2 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008901 300.0
HFD2_k127_7894396_0 Rho termination factor, RNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006369 337.0
HFD2_k127_7894396_1 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008497 304.0
HFD2_k127_7894396_2 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000007908 226.0
HFD2_k127_7894396_3 Aerotolerance regulator N-terminal - - - 0.000000000000000000000000000000000000000000000000001338 203.0
HFD2_k127_7894396_4 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000003651 78.0
HFD2_k127_7894396_5 OmpA family K03286 - - 0.000000346 63.0
HFD2_k127_7894396_6 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.000002783 56.0
HFD2_k127_7898279_0 aconitate hydratase K01681 - 4.2.1.3 2.926e-230 724.0
HFD2_k127_7898279_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 482.0
HFD2_k127_7898279_2 Nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009993 334.0
HFD2_k127_7898279_3 4Fe-4S binding domain K08358 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007571 317.0
HFD2_k127_7898279_4 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K22110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002371 292.0
HFD2_k127_7898279_5 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K04013,K15876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001166 269.0
HFD2_k127_7898279_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000019 120.0
HFD2_k127_7898279_7 - - - - 0.000000000000000001378 94.0
HFD2_k127_7900889_0 Heat shock 70 kDa protein K04043 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007373 412.0
HFD2_k127_7900889_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009495 332.0
HFD2_k127_7900889_2 Rhomboid family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001403 268.0
HFD2_k127_7900889_3 negative regulation of phosphate transmembrane transport K02039 GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000000000000000000000001104 228.0
HFD2_k127_7909746_0 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005292 376.0
HFD2_k127_7909746_1 PFAM NAD-dependent epimerase dehydratase K01784,K10011,K12449 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016741,GO:0016742,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0022607,GO:0033319,GO:0033320,GO:0034214,GO:0034641,GO:0034654,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046349,GO:0046483,GO:0046677,GO:0048037,GO:0048040,GO:0050662,GO:0050896,GO:0051259,GO:0051287,GO:0055086,GO:0055114,GO:0065003,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:0099618,GO:0099619,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:2001313,GO:2001315 1.1.1.305,2.1.2.13,5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 363.0
HFD2_k127_7909746_2 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001618 256.0
HFD2_k127_7909746_3 Roadblock/LC7 domain - - - 0.00000000000000000000000000000000000000000000000000000003752 209.0
HFD2_k127_7909746_4 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000002424 91.0
HFD2_k127_7909746_5 Polysaccharide biosynthesis protein - - - 0.00000000005568 74.0
HFD2_k127_7909746_6 Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.0002523 53.0
HFD2_k127_7946744_0 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005621 427.0
HFD2_k127_7946744_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 302.0
HFD2_k127_7946744_10 Domain of unknown function (DUF309) K09763 - - 0.00000000004076 68.0
HFD2_k127_7946744_11 Ferredoxin K04755 - - 0.0000000008855 67.0
HFD2_k127_7946744_12 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000005519 61.0
HFD2_k127_7946744_13 Redoxin K03564 - 1.11.1.15 0.0000537 52.0
HFD2_k127_7946744_2 KR domain K03793 - 1.5.1.33 0.0000000000000000000000000000000000000000000000000000000000000000002583 236.0
HFD2_k127_7946744_3 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.00000000000000000000000000000000000000000000000000000000000000001218 234.0
HFD2_k127_7946744_4 - - - - 0.00000000000000000000000000000000000000000000000000004549 203.0
HFD2_k127_7946744_5 COGs COG0491 Zn-dependent hydrolase including glyoxylase - - - 0.00000000000000000000000000000000000000000000000000005269 205.0
HFD2_k127_7946744_6 Fumarase C C-terminus K01744 - 4.3.1.1 0.0000000000000000000000000000000000000000004492 160.0
HFD2_k127_7946744_7 KR domain - - - 0.0000000000000000000000000001026 126.0
HFD2_k127_7946744_8 - - - - 0.000000000000000005524 91.0
HFD2_k127_7946744_9 Redoxin - - - 0.0000000000000006063 81.0
HFD2_k127_7952288_0 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 314.0
HFD2_k127_7952288_1 - - - - 0.00000000000000000000000000000000000004039 155.0
HFD2_k127_7952288_2 DNA-binding transcription factor activity - - - 0.000000000000000000000000000008252 127.0
HFD2_k127_7954164_0 Melibiase K07407 - 3.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007856 455.0
HFD2_k127_7954164_1 - - - - 0.0000000000000006587 89.0
HFD2_k127_7954164_2 PFAM blue (type 1) copper domain protein K00728 - 2.4.1.109 0.0000000000001239 82.0
HFD2_k127_7954164_3 repeat protein - - - 0.0000002493 54.0
HFD2_k127_7954164_4 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000001289 53.0
HFD2_k127_7960733_0 DoxX - - - 0.0000000000000000000000000000000000000000000001999 180.0
HFD2_k127_7960733_1 Transcriptional regulator PadR-like family - - - 0.00000000000000000000006774 101.0
HFD2_k127_7960733_2 - - - - 0.0000000002492 73.0
HFD2_k127_7960733_3 Histidine kinase - - - 0.00007062 45.0
HFD2_k127_7964330_0 Participates in both transcription termination and antitermination K02600 - - 2.635e-199 629.0
HFD2_k127_7964330_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000006218 80.0
HFD2_k127_7964330_2 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family - - - 0.00000000009615 68.0
HFD2_k127_7965732_0 Integrase core domain K07497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 291.0
HFD2_k127_7965732_1 Transposase K07483 - - 0.00000000000003556 76.0
HFD2_k127_7965732_3 Uncharacterized conserved protein (DUF2164) - - - 0.0000009189 52.0
HFD2_k127_7970942_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 359.0
HFD2_k127_7970942_1 PFAM Cache K08738 - - 0.0000000000000000000000000000000000000000000000000000000000001796 238.0
HFD2_k127_7970942_2 MotA/TolQ/ExbB proton channel family K03562 - - 0.000000000000000000000000000000000000000000000000002256 190.0
HFD2_k127_7970942_3 Uncharacterised protein family UPF0066 - - - 0.000000000000000000000000000000000000000000000000003665 185.0
HFD2_k127_7970942_4 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000000000000000000000008047 153.0
HFD2_k127_7970942_5 PFAM Cache type 2 domain protein - - - 0.000000000000000000000004729 119.0
HFD2_k127_7970942_6 Biopolymer transport protein ExbD/TolR K03559 - - 0.000000000000000000009441 101.0
HFD2_k127_7970942_7 Biopolymer transport protein ExbD/TolR K03560 - - 0.00000000000000004717 89.0
HFD2_k127_7970942_8 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000297 89.0
HFD2_k127_7970942_9 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.0000000000000009291 84.0
HFD2_k127_7973371_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 608.0
HFD2_k127_7973371_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000000000000000000000000000000000000000000000000000000000000000000002967 265.0
HFD2_k127_7973371_2 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000001621 244.0
HFD2_k127_7973371_3 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000612 195.0
HFD2_k127_7973371_4 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000003242 111.0
HFD2_k127_7975827_0 phosphorelay signal transduction system K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 409.0
HFD2_k127_7975827_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002559 277.0
HFD2_k127_7975827_2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000004132 198.0
HFD2_k127_7998455_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006118 400.0
HFD2_k127_7998455_1 - - - - 0.00001106 55.0
HFD2_k127_8000062_0 Carbohydrate family 9 binding domain-like - - - 1.04e-251 795.0
HFD2_k127_8000062_1 DHH family K06881 - 3.1.13.3,3.1.3.7 0.00000000000000000000005509 100.0
HFD2_k127_8008400_0 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006921 400.0
HFD2_k127_8008400_1 - - - - 0.00000000003727 70.0
HFD2_k127_8012617_0 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005852 368.0
HFD2_k127_8012617_1 COG1668 ABC-type Na efflux pump, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000132 283.0
HFD2_k127_8012617_2 SUF system FeS assembly protein K04488 - - 0.00000000000000000000000000000000000000000000001795 178.0
HFD2_k127_8012617_3 Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under specific conditions such as oxidative stress and iron limitation. Acts as a potent selenocysteine lyase in vitro, that mobilizes selenium from L-selenocysteine. Selenocysteine lyase activity is however unsure in vivo K01766,K11717 GO:0001887,GO:0003674,GO:0003824,GO:0005488,GO:0006464,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009000,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0019538,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031162,GO:0031163,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564 2.8.1.7,4.4.1.16 0.000000000000000000000000000008756 119.0
HFD2_k127_8012617_4 PFAM Flp Fap pilin component K02651 - - 0.00004824 51.0
HFD2_k127_8022468_0 histidine kinase A domain protein K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 324.0
HFD2_k127_8022468_1 - - - - 0.000000000000000000000000000000000000001438 153.0
HFD2_k127_8033452_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 407.0
HFD2_k127_8033452_1 ABC transporter K09817 - - 0.0000000000000000000000000000000000000000000000000000000000000000002027 241.0
HFD2_k127_8033452_2 GYD domain - - - 0.0000000000000000000000000000000000001048 145.0
HFD2_k127_8033452_3 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.0000000000000000000000007286 109.0
HFD2_k127_8041831_0 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 2.559e-232 741.0
HFD2_k127_8041831_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008796 370.0
HFD2_k127_8041831_2 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 325.0
HFD2_k127_8041831_3 HNH nucleases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004732 290.0
HFD2_k127_8041831_4 Amidohydrolase family K12960,K20810 - 3.5.4.28,3.5.4.31,3.5.4.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005568 293.0
HFD2_k127_8041831_5 - - - - 0.00000000000000000000000000006622 126.0
HFD2_k127_8041831_6 surface antigen K07001 - - 0.00000228 51.0
HFD2_k127_8044131_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1101.0
HFD2_k127_8044131_1 Carboxypeptidase - - - 0.0000007178 51.0
HFD2_k127_8046640_0 BNR Asp-box repeat - - - 5.825e-253 791.0
HFD2_k127_8048002_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003555 455.0
HFD2_k127_8048002_1 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 349.0
HFD2_k127_8048002_2 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000007778 243.0
HFD2_k127_8048002_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000001926 239.0
HFD2_k127_8048002_4 ECF sigma factor K03088 - - 0.000000000000000000000000000002066 128.0
HFD2_k127_8049456_0 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 357.0
HFD2_k127_8049456_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008588 270.0
HFD2_k127_8049456_2 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000005727 239.0
HFD2_k127_8049456_3 MacB-like periplasmic core domain K02004 - - 0.0000000000001082 78.0
HFD2_k127_8049931_0 chaperone-mediated protein folding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 390.0
HFD2_k127_8049931_1 SnoaL-like domain - - - 0.000000000001142 75.0
HFD2_k127_8060129_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 338.0
HFD2_k127_8060129_1 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000003671 244.0
HFD2_k127_8060129_2 Membrane - - - 0.000000000000004534 79.0
HFD2_k127_8062711_0 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 499.0
HFD2_k127_8062711_1 - - - - 0.000000003792 69.0
HFD2_k127_8065469_0 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 5.514e-207 657.0
HFD2_k127_8065469_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 567.0
HFD2_k127_8065469_10 S4 RNA-binding domain K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000006911 196.0
HFD2_k127_8065469_11 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.0000000000000000000000000000000000000000001294 172.0
HFD2_k127_8065469_12 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000008933 122.0
HFD2_k127_8065469_13 Zinc finger domain - - - 0.00000000000000002513 93.0
HFD2_k127_8065469_14 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000002406 76.0
HFD2_k127_8065469_15 - K01822 - 5.3.3.1 0.00000004229 64.0
HFD2_k127_8065469_16 HEAT repeats - - - 0.0000006747 62.0
HFD2_k127_8065469_17 deoxyhypusine monooxygenase activity - - - 0.0002297 54.0
HFD2_k127_8065469_2 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 518.0
HFD2_k127_8065469_3 Polysaccharide biosynthesis protein K02851 - 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006357 452.0
HFD2_k127_8065469_4 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 434.0
HFD2_k127_8065469_5 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004298 293.0
HFD2_k127_8065469_6 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K00090 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000008211 263.0
HFD2_k127_8065469_7 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004469 250.0
HFD2_k127_8065469_8 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000482 247.0
HFD2_k127_8065469_9 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000326 254.0
HFD2_k127_8078776_0 Metallopeptidase family M24 K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005315 336.0
HFD2_k127_8078776_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.0000000000000000000000000000000000000000000000003094 182.0
HFD2_k127_8078776_2 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000001045 68.0
HFD2_k127_8086790_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 7.067e-245 771.0
HFD2_k127_8086790_1 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 467.0
HFD2_k127_8086790_10 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000001392 245.0
HFD2_k127_8086790_11 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000005958 230.0
HFD2_k127_8086790_12 Biotin-lipoyl like K01993 - - 0.0000000000000000000000000000000000000000000000000007589 195.0
HFD2_k127_8086790_13 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000003399 188.0
HFD2_k127_8086790_14 - - - - 0.000000000004099 75.0
HFD2_k127_8086790_15 Rho termination factor, RNA-binding domain K03628 - - 0.000003426 52.0
HFD2_k127_8086790_2 ROK family K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 406.0
HFD2_k127_8086790_3 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 351.0
HFD2_k127_8086790_4 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 341.0
HFD2_k127_8086790_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006888 337.0
HFD2_k127_8086790_6 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 330.0
HFD2_k127_8086790_7 ABC transporter K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 291.0
HFD2_k127_8086790_8 Part of the ABC transporter FtsEX involved in K09811 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007022 275.0
HFD2_k127_8086790_9 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005647 270.0
HFD2_k127_8089553_0 cyclic nucleotide binding K12132,K20074 - 2.7.11.1,3.1.3.16 0.00000000000000000000000000000000000000000000000000004275 214.0
HFD2_k127_8089553_1 Bacterial transcriptional activator domain - - - 0.000000000000000000000000581 121.0
HFD2_k127_8089553_2 Copper binding proteins, plastocyanin/azurin family K02638 - - 0.000000000000000000000002771 109.0
HFD2_k127_8095099_0 epimerase dehydratase K08679 - 5.1.3.6 0.0000000000000000000000000000000000000000000000000000006494 198.0
HFD2_k127_8095099_1 TPR repeat - - - 0.0000000000000000000000000003532 124.0
HFD2_k127_8095425_0 ABC transporter K01990,K21397 - - 0.0000000000000001386 94.0
HFD2_k127_8095425_1 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0000000000002531 83.0
HFD2_k127_8105359_0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002166 443.0
HFD2_k127_8105359_2 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.000000000003564 79.0
HFD2_k127_8111765_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008309 505.0
HFD2_k127_8111765_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000006708 230.0
HFD2_k127_8111765_2 Amino acid kinase family K00926 - 2.7.2.2 0.0000000000000000000000000000000000006601 144.0
HFD2_k127_8114618_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004164 271.0
HFD2_k127_8114618_1 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000757 246.0
HFD2_k127_8114618_2 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000000000000000000002373 228.0
HFD2_k127_8114618_3 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000001258 218.0
HFD2_k127_8114618_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000002275 102.0
HFD2_k127_8126326_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005026 439.0
HFD2_k127_8126326_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 373.0
HFD2_k127_8143986_0 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001128 251.0
HFD2_k127_8143986_1 Bacterial transcriptional repressor C-terminal K09017 - - 0.0000000000000000000000000000000000000000000000000000000000000000005588 234.0
HFD2_k127_8143986_2 Biotin-lipoyl like K03543 - - 0.00000000000000000000000001275 116.0
HFD2_k127_8143986_3 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00973 - 2.7.7.24 0.00009384 47.0
HFD2_k127_8156213_0 metallocarboxypeptidase activity K14054 - - 0.0 1169.0
HFD2_k127_8156213_1 PFAM aldo keto reductase K19265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 481.0
HFD2_k127_8156213_2 SMART ATP-binding region ATPase domain protein - - - 0.000000000000000000000003751 115.0
HFD2_k127_8156213_3 cell adhesion involved in biofilm formation K01186 - 3.2.1.18 0.0003206 49.0
HFD2_k127_8168441_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 2.829e-201 644.0
HFD2_k127_8168441_1 LVIVD repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 383.0
HFD2_k127_8168441_2 dUTPase K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004396 319.0
HFD2_k127_8168441_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 293.0
HFD2_k127_8168441_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000001693 242.0
HFD2_k127_8168441_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000002149 138.0
HFD2_k127_8168441_6 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000015 128.0
HFD2_k127_8169389_0 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 385.0
HFD2_k127_8169389_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007774 291.0
HFD2_k127_8169389_2 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000296 173.0
HFD2_k127_8169389_3 LVIVD repeat - - - 0.000000000000000000000000000000000000001142 166.0
HFD2_k127_8169389_4 Molybdopterin guanine dinucleotide synthesis protein B K03750,K03753,K13818 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.10.1.1,2.7.7.77 0.00000000000000008608 92.0
HFD2_k127_8193938_0 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000000000000000000004714 196.0
HFD2_k127_8193938_1 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000004852 194.0
HFD2_k127_8193938_2 OsmC-like protein - - - 0.00000000000000000000000000000000004305 138.0
HFD2_k127_8206473_0 Helix-hairpin-helix motif K02337 - 2.7.7.7 0.0 1118.0
HFD2_k127_8206473_1 tRNA synthetases class I (M) K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004665 557.0
HFD2_k127_8206473_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 425.0
HFD2_k127_8206473_3 PSP1 C-terminal conserved region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002906 353.0
HFD2_k127_8206473_4 Peptidase family M23 - - - 0.0000000000000000000000000000000000000215 156.0
HFD2_k127_8217920_0 MMPL family K03296 - - 1.43e-252 799.0
HFD2_k127_8217920_1 Biotin-lipoyl like K07799 - - 0.0000000000000000000000000000000000000000000000000000008589 199.0
HFD2_k127_8227126_0 PFAM Glycoside hydrolase 15-related - - - 7.004e-272 854.0
HFD2_k127_8227126_1 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 0.0000000000000000000000000000000000000000000000000000005183 194.0
HFD2_k127_8227126_2 Hsp20/alpha crystallin family - - - 0.0000000001139 69.0
HFD2_k127_8255083_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 8.201e-194 638.0
HFD2_k127_8255083_1 Amino acid permease - - - 0.000000000000000000000000000000000003791 150.0
HFD2_k127_8255083_2 Acid phosphatase homologues - - - 0.00000000000004975 85.0
HFD2_k127_8275918_0 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 417.0
HFD2_k127_8275918_1 PFAM Cytochrome c oxidase, subunit I K04561 - 1.7.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000118 286.0
HFD2_k127_8275918_2 Copper binding proteins, plastocyanin/azurin family - - - 0.0000000000000000000000000000000000000000000000002318 181.0
HFD2_k127_8275918_3 - - - - 0.00000000000000000000000000000000000000000573 160.0
HFD2_k127_8275918_4 Dehydrogenase - - - 0.000000000000000000000000000000002097 133.0
HFD2_k127_8275918_5 cytochrome c K02305 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000003522 113.0
HFD2_k127_8321887_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008257 397.0
HFD2_k127_8321887_1 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000284 291.0
HFD2_k127_8321887_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000006722 141.0
HFD2_k127_8321887_3 Cell division protein FtsQ K03589 - - 0.00000000000000000000000000005558 126.0
HFD2_k127_8354707_0 Hsp70 protein K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008242 594.0
HFD2_k127_8354707_1 geranylgeranyl reductase activity K10960,K17830 - 1.3.1.101,1.3.1.111,1.3.1.83,1.3.7.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003123 290.0
HFD2_k127_8354707_2 rod shape-determining protein MreC K03570 - - 0.00000000000000000000000000000000000000000000000007809 192.0
HFD2_k127_8354707_3 Glucose inhibited division protein A K03388,K16885 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000002181 63.0
HFD2_k127_8435729_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 421.0
HFD2_k127_8435729_1 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006881 292.0
HFD2_k127_8435729_2 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000002316 225.0
HFD2_k127_8435729_3 Amidohydrolase family - - - 0.0000000001995 74.0
HFD2_k127_8493753_0 efflux transmembrane transporter activity - - - 1.632e-305 962.0
HFD2_k127_8493753_1 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 8.467e-211 666.0
HFD2_k127_8493753_2 Bacterial transcriptional repressor C-terminal K16137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000299 240.0
HFD2_k127_8493753_3 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000000000000000000005952 180.0
HFD2_k127_8493753_4 - - - - 0.00000000000000000000000000000000000000000000002449 176.0
HFD2_k127_8493753_5 Amino acid permease - - - 0.00000000000000000000000000000000009459 137.0
HFD2_k127_8493753_6 Cupin domain - - - 0.00000000000000000001799 94.0
HFD2_k127_8493753_7 Regulatory protein, FmdB family - - - 0.0000000000000000007453 89.0
HFD2_k127_8494464_0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 448.0
HFD2_k127_8494464_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 429.0
HFD2_k127_8494464_2 Zinc dependent phospholipase C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 361.0
HFD2_k127_8525900_0 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 460.0
HFD2_k127_8525900_1 Homoserine dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000153 276.0
HFD2_k127_8525900_2 Carbon-nitrogen hydrolase K03820 - - 0.000000000000000000000000000000000000000000000000000000000000002224 244.0
HFD2_k127_876825_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 568.0
HFD2_k127_876825_1 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 395.0
HFD2_k127_876825_2 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000216 282.0
HFD2_k127_876825_3 Regulator of chromosome condensation (RCC1) repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000009702 253.0
HFD2_k127_876825_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000002291 102.0
HFD2_k127_877009_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 307.0
HFD2_k127_877009_1 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0030312,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.000000000000000000000000000000000000000000000000006127 194.0
HFD2_k127_877009_2 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000003009 107.0
HFD2_k127_877009_3 Protein of unknown function (DUF503) K09764 - - 0.0000000000000000000008904 97.0
HFD2_k127_88569_0 Alpha mannosidase, middle domain K01191 - 3.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 516.0
HFD2_k127_88569_1 Belongs to the GPI family K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000002496 232.0
HFD2_k127_88569_2 Serine hydrolase (FSH1) - - - 0.0000000000000000000000000000000000000000000000003772 189.0
HFD2_k127_88569_3 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000003032 176.0
HFD2_k127_897712_0 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K06898,K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009726 313.0
HFD2_k127_897712_1 Biopterin-dependent aromatic amino acid hydroxylase K00500 - 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001031 273.0
HFD2_k127_897712_2 chaperone-mediated protein folding - - - 0.00000000000000000001347 106.0
HFD2_k127_897712_3 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.00000000000000000005997 92.0
HFD2_k127_897712_4 chaperone-mediated protein folding K02660 - - 0.000000000007982 78.0
HFD2_k127_897712_5 - - - - 0.0004026 45.0
HFD2_k127_90513_0 Protein of unknown function (DUF512) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 455.0
HFD2_k127_90513_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000675 456.0
HFD2_k127_90513_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 332.0
HFD2_k127_90513_3 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 334.0
HFD2_k127_90513_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000005554 232.0
HFD2_k127_90513_5 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000002336 222.0
HFD2_k127_90513_6 helix_turn_helix, mercury resistance - - - 0.00000000000000000000000000000000000000000000001679 174.0
HFD2_k127_90513_7 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000001346 166.0
HFD2_k127_90513_8 Glycosyl transferase family 2 - - - 0.0000000000000000000000001489 115.0
HFD2_k127_90513_9 PFAM acylphosphatase K01512 - 3.6.1.7 0.0000000004351 64.0
HFD2_k127_918182_0 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 372.0
HFD2_k127_918182_1 Sodium:dicarboxylate symporter family K03309 - - 0.000000000000000000000000000000000000000000000002771 176.0
HFD2_k127_918182_2 BadF/BadG/BcrA/BcrD ATPase family K18676 - 2.7.1.8 0.000000000000000000000000000000000000001075 160.0
HFD2_k127_918182_3 Ribonuclease B OB domain K03704 - - 0.00000000000008366 75.0
HFD2_k127_918480_0 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 1.082e-217 700.0
HFD2_k127_918480_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009016 279.0
HFD2_k127_918480_2 PFAM Acetyltransferase (GNAT) family K06976 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005394 259.0
HFD2_k127_918480_3 Large extracellular alpha-helical protein K06894 - - 0.0000000000000000000000000000000000327 136.0
HFD2_k127_918480_4 PFAM Transglycosylase-associated protein - - - 0.00000000000000000664 86.0
HFD2_k127_919089_0 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 494.0
HFD2_k127_919089_1 Membrane dipeptidase (Peptidase family M19) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003974 279.0
HFD2_k127_919089_2 Sulfotransferase family - - - 0.0000000004079 74.0
HFD2_k127_928509_0 diguanylate cyclase - - - 0.00000000000000000000000000000001056 132.0
HFD2_k127_928509_1 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.00000000001269 77.0
HFD2_k127_934055_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003748 458.0
HFD2_k127_934055_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 316.0
HFD2_k127_934055_2 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000002078 108.0
HFD2_k127_935360_0 DDE superfamily endonuclease K07494 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007419 298.0
HFD2_k127_935360_1 Winged helix-turn helix K07499 - - 0.000000000000000000000000000000000001875 143.0
HFD2_k127_935360_2 uridine kinase K00876 - 2.7.1.48 0.0000006355 52.0
HFD2_k127_935613_0 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000176 164.0
HFD2_k127_935613_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000005057 88.0
HFD2_k127_93752_0 Oxygenase, catalysing oxidative methylation of damaged DNA K09990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000319 366.0
HFD2_k127_93752_1 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009038 321.0
HFD2_k127_93752_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005514 262.0
HFD2_k127_93752_3 Protein of unknown function (DUF1706) - - - 0.00000000000000000000000000000000000000000000000000001929 193.0
HFD2_k127_93752_5 - - - - 0.000001416 52.0
HFD2_k127_941616_0 FAD binding domain K09828 - 1.3.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004134 592.0
HFD2_k127_941616_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 412.0
HFD2_k127_941616_2 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 338.0
HFD2_k127_941616_3 hydrolase activity, hydrolyzing O-glycosyl compounds K00689 GO:0005575,GO:0005576 2.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 306.0
HFD2_k127_941616_4 NIPSNAP - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006463 292.0
HFD2_k127_941616_5 HD domain K07023 - - 0.00000000000000000000000000000000000000000000000000006914 190.0
HFD2_k127_941616_6 - - - - 0.0000000000000000000000001762 124.0
HFD2_k127_946235_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 8.207e-292 910.0
HFD2_k127_946235_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 5.133e-204 637.0
HFD2_k127_946235_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002098 248.0
HFD2_k127_946235_3 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000006681 220.0
HFD2_k127_949135_0 Bacterial protein of unknown function (DUF853) K06915 - - 0.00000000000000000000000000000000000000000000000000303 193.0
HFD2_k127_949135_1 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000005467 190.0
HFD2_k127_949135_2 - - - - 0.0000000000000001223 88.0
HFD2_k127_949135_3 - - - - 0.0000007989 58.0
HFD2_k127_950443_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000011 267.0
HFD2_k127_950443_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.000000000000007758 88.0
HFD2_k127_966447_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 378.0
HFD2_k127_966447_1 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000001959 194.0
HFD2_k127_966447_2 His Kinase A (phosphoacceptor) domain - - - 0.0000009869 57.0
HFD2_k127_974828_0 PFAM amidohydrolase - - - 2.366e-194 623.0
HFD2_k127_974828_1 RDD family - - - 0.0000000000000000000000000000000000000000009258 165.0
HFD2_k127_974828_2 COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - 0.0000000000000000000000000000401 121.0
HFD2_k127_975810_0 type II secretion system protein E K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003594 531.0
HFD2_k127_975810_1 Belongs to the GSP D family K02280 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000611 286.0
HFD2_k127_975810_2 Flp pilus polar localization response receiver ATPase TadZ, FlhG domain-containing K02282 - - 0.000000000000000000000000000000000000000000000005705 188.0
HFD2_k127_975810_3 Putative Flp pilus-assembly TadE/G-like - - - 0.000000000000000000000000000000008424 142.0
HFD2_k127_975810_4 Type II secretion system (T2SS), protein F K12510 - - 0.00000000000000001378 89.0
HFD2_k127_978678_0 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 410.0
HFD2_k127_978678_1 Protein kinase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009717 363.0
HFD2_k127_978678_2 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000000000000000000000000000000000000000000000000000001653 223.0
HFD2_k127_98780_0 aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002981 299.0
HFD2_k127_98780_1 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000229 265.0
HFD2_k127_98780_2 Penicillinase repressor - - - 0.0000000000000000000000000000000002806 135.0
HFD2_k127_98780_3 - - - - 0.00000000003542 74.0
HFD2_k127_98780_4 endoribonuclease L-PSP - - - 0.000001223 62.0
HFD2_k127_996405_0 MacB-like periplasmic core domain - - - 3.268e-260 819.0
HFD2_k127_996405_1 PFAM Protein kinase K03413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 426.0
HFD2_k127_99641_0 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000053 336.0
HFD2_k127_99641_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003929 275.0
HFD2_k127_99641_2 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000002157 229.0
HFD2_k127_99641_3 extracellular matrix structural constituent - - - 0.000001933 61.0