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Overview

ID MAG01672
Name HFD2_bin.9
Sample SMP0044
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family SG8-39
Genus SCGC-AG-212-J23
Species
Assembly information
Completeness (%) 84.2
Contamination (%) 6.44
GC content (%) 69.0
N50 (bp) 12,753
Genome size (bp) 3,318,053

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3529

Gene name Description KEGG GOs EC E-value Score Sequence
HFD2_k127_1003066_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005361 351.0
HFD2_k127_1003066_1 Isocitrate lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005419 285.0
HFD2_k127_1003066_2 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000001616 265.0
HFD2_k127_1003066_3 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000000000005218 181.0
HFD2_k127_1003066_4 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000001833 188.0
HFD2_k127_1005783_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 0.0 1391.0
HFD2_k127_1005783_1 Peptidase family M3 K01414 - 3.4.24.70 2.333e-311 981.0
HFD2_k127_1005783_10 Domain of unknown function (DUF4124) - - - 0.0000000000000000004198 89.0
HFD2_k127_1005783_2 Belongs to the malate synthase family K01638 - 2.3.3.9 2.427e-237 744.0
HFD2_k127_1005783_3 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 1.62e-213 677.0
HFD2_k127_1005783_4 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 487.0
HFD2_k127_1005783_5 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 392.0
HFD2_k127_1005783_6 PFAM luciferase family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 388.0
HFD2_k127_1005783_7 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 353.0
HFD2_k127_1005783_8 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 342.0
HFD2_k127_1005783_9 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 347.0
HFD2_k127_1084097_0 Belongs to the thiolase family K00626 - 2.3.1.9 7.427e-213 671.0
HFD2_k127_1084097_1 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 - 2.7.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 371.0
HFD2_k127_1084097_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001306 256.0
HFD2_k127_1103168_0 protein conserved in bacteria K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 489.0
HFD2_k127_1103168_1 surface antigen K07278 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008109 404.0
HFD2_k127_1103168_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008644 358.0
HFD2_k127_1103168_3 Lytic murein transglycosylase K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 301.0
HFD2_k127_1103168_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000002107 253.0
HFD2_k127_1103168_5 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000976 236.0
HFD2_k127_1103168_6 peptidase K06194 - - 0.000000000000000000000000000000000000000000000002443 192.0
HFD2_k127_1103168_7 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000008045 56.0
HFD2_k127_1126823_0 histidine kinase HAMP region domain protein K03406,K03776,K05875 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006135 393.0
HFD2_k127_1126823_1 Two component signalling adaptor domain K03408 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002334 249.0
HFD2_k127_1126823_2 histidine kinase HAMP region domain protein K03406,K03776,K05874 - - 0.0000000000000106 75.0
HFD2_k127_1147327_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1193.0
HFD2_k127_1147327_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 2.008e-200 633.0
HFD2_k127_1147327_10 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 432.0
HFD2_k127_1147327_11 luciferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 365.0
HFD2_k127_1147327_12 histidine kinase HAMP region domain protein K07649 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004257 372.0
HFD2_k127_1147327_13 COG0501 Zn-dependent protease with chaperone function K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008553 372.0
HFD2_k127_1147327_14 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 331.0
HFD2_k127_1147327_15 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 313.0
HFD2_k127_1147327_16 Molybdenum cofactor biosynthesis protein K03831 - 2.7.7.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008929 305.0
HFD2_k127_1147327_17 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006614 308.0
HFD2_k127_1147327_18 COG0501 Zn-dependent protease with chaperone function K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 311.0
HFD2_k127_1147327_19 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 294.0
HFD2_k127_1147327_2 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 544.0
HFD2_k127_1147327_20 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008839 292.0
HFD2_k127_1147327_21 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001191 269.0
HFD2_k127_1147327_22 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007303 262.0
HFD2_k127_1147327_23 PFAM LemA family protein K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002978 257.0
HFD2_k127_1147327_24 Phospholipase/Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001188 268.0
HFD2_k127_1147327_25 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002658 242.0
HFD2_k127_1147327_26 metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain K07050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003565 249.0
HFD2_k127_1147327_27 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000008892 238.0
HFD2_k127_1147327_28 Sulfatase-modifying factor enzyme 1 K11912 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000003156 229.0
HFD2_k127_1147327_29 Belongs to the arginase family K01476,K01480,K12255,K18459 - 3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7 0.0000000000000000000000000000000000000000000000000000000000000004762 233.0
HFD2_k127_1147327_3 Ferrous iron transport protein B K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 479.0
HFD2_k127_1147327_30 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000000000000000000005642 226.0
HFD2_k127_1147327_32 Lumazine binding domain K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000000000001629 211.0
HFD2_k127_1147327_33 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000002379 200.0
HFD2_k127_1147327_34 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000005515 200.0
HFD2_k127_1147327_35 carbon monoxide dehydrogenase subunit g K09386 - - 0.000000000000000000000000000000000000000000000000004379 188.0
HFD2_k127_1147327_36 Forkhead associated domain - - - 0.00000000000000000000000000000000000000000000000002209 197.0
HFD2_k127_1147327_37 Protein of unknown function (DUF3237) - - - 0.00000000000000000000000000000000000000000000000005012 181.0
HFD2_k127_1147327_38 Molybdopterin-guanine dinucleotide biosynthesis protein MobA K07141 - 2.7.7.76 0.0000000000000000000000000000000000000000002107 177.0
HFD2_k127_1147327_39 TIGRFAM ATP-dependent helicase HrpA K03578 - 3.6.4.13 0.00000000000000000000000000000000000000006406 171.0
HFD2_k127_1147327_4 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 443.0
HFD2_k127_1147327_40 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000001793 145.0
HFD2_k127_1147327_41 Belongs to the UPF0307 family K09889 - - 0.0000000000000000000000000000000009416 150.0
HFD2_k127_1147327_42 Nitrous oxide-stimulated promoter - - - 0.00000000000000000000000000001874 124.0
HFD2_k127_1147327_44 - - - - 0.00000000000000002399 87.0
HFD2_k127_1147327_45 Neurogenic locus notch homolog protein K20996 GO:0000139,GO:0000902,GO:0000904,GO:0001525,GO:0001568,GO:0001569,GO:0001709,GO:0001763,GO:0001885,GO:0001886,GO:0001944,GO:0002009,GO:0002064,GO:0002376,GO:0002520,GO:0003158,GO:0003382,GO:0003674,GO:0005102,GO:0005112,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005783,GO:0005789,GO:0005794,GO:0005829,GO:0005886,GO:0005887,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006357,GO:0006366,GO:0006367,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0007219,GO:0007221,GO:0007275,GO:0008150,GO:0008152,GO:0008593,GO:0009058,GO:0009059,GO:0009653,GO:0009888,GO:0009889,GO:0009891,GO:0009893,GO:0009966,GO:0009968,GO:0009986,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010646,GO:0010648,GO:0012505,GO:0016020,GO:0016021,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022603,GO:0023051,GO:0023052,GO:0023057,GO:0030097,GO:0030154,GO:0030162,GO:0030855,GO:0030856,GO:0030857,GO:0030879,GO:0031090,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031984,GO:0032501,GO:0032502,GO:0032774,GO:0032879,GO:0032880,GO:0032989,GO:0034641,GO:0034645,GO:0034654,GO:0035239,GO:0035295,GO:0038023,GO:0042175,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044431,GO:0044432,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0045165,GO:0045446,GO:0045595,GO:0045596,GO:0045601,GO:0045602,GO:0045746,GO:0045765,GO:0045766,GO:0045893,GO:0045935,GO:0045944,GO:0046483,GO:0046872,GO:0046982,GO:0046983,GO:0048468,GO:0048513,GO:0048514,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048583,GO:0048585,GO:0048646,GO:0048729,GO:0048731,GO:0048732,GO:0048754,GO:0048845,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051093,GO:0051094,GO:0051171,GO:0051173,GO:0051239,GO:0051240,GO:0051246,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0060429,GO:0060562,GO:0060841,GO:0061138,GO:0065007,GO:0070013,GO:0070613,GO:0071704,GO:0071840,GO:0071944,GO:0072358,GO:0072359,GO:0080090,GO:0090304,GO:0097659,GO:0097708,GO:0098588,GO:0098791,GO:0098827,GO:1901342,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903317,GO:1903506,GO:1903508,GO:1903847,GO:1903849,GO:1904018,GO:1905651,GO:1905653,GO:2000026,GO:2000112,GO:2001141 - 0.000000000000001962 83.0
HFD2_k127_1147327_46 SPW repeat - - - 0.00000000000001588 81.0
HFD2_k127_1147327_47 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000003496 75.0
HFD2_k127_1147327_5 XdhC and CoxI family K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 418.0
HFD2_k127_1147327_6 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 428.0
HFD2_k127_1147327_7 Malonyl-CoA decarboxylase N-terminal domain K01578 - 4.1.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 423.0
HFD2_k127_1147327_8 ATP ADP translocase K03301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 434.0
HFD2_k127_1147327_9 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 415.0
HFD2_k127_1181369_0 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 2.014e-267 850.0
HFD2_k127_1181369_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 466.0
HFD2_k127_1181369_2 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 356.0
HFD2_k127_1181369_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006629 282.0
HFD2_k127_1181369_4 HAD-superfamily hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000003622 230.0
HFD2_k127_1181369_5 Low molecular weight phosphotyrosine protein phosphatase K01104 GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 0.000000000000000000000000000000000000000000002903 175.0
HFD2_k127_1181369_6 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000006639 138.0
HFD2_k127_1202445_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 9.915e-199 625.0
HFD2_k127_1202445_1 Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 339.0
HFD2_k127_1202445_2 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000001085 261.0
HFD2_k127_1217499_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.214e-197 623.0
HFD2_k127_1217499_1 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 482.0
HFD2_k127_1217499_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002755 426.0
HFD2_k127_1217499_3 PFAM Uroporphyrinogen decarboxylase (URO-D) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003317 372.0
HFD2_k127_1217499_4 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 327.0
HFD2_k127_1217499_5 Methionine synthase B12-binding module cap domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005445 306.0
HFD2_k127_1217499_6 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007494 264.0
HFD2_k127_1217499_7 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000000001926 196.0
HFD2_k127_1248241_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1420.0
HFD2_k127_1248241_1 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 393.0
HFD2_k127_1248241_10 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000001693 125.0
HFD2_k127_1248241_11 - - - - 0.00006296 55.0
HFD2_k127_1248241_2 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007279 336.0
HFD2_k127_1248241_3 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000002922 250.0
HFD2_k127_1248241_4 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000000000000000000000000000000000000009566 233.0
HFD2_k127_1248241_5 glyoxalase K07032 - - 0.000000000000000000000000000000000000000000000000000000000000002335 227.0
HFD2_k127_1248241_6 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000000007967 221.0
HFD2_k127_1248241_7 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000002932 205.0
HFD2_k127_1248241_8 transcriptional regulator K07734 - - 0.0000000000000000000000000000000000000000000001494 175.0
HFD2_k127_1248241_9 Haem-degrading - - - 0.000000000000000000000000000000000000000000001543 178.0
HFD2_k127_1261111_0 glutaminyl-tRNA K01886 - 6.1.1.18 1.987e-247 773.0
HFD2_k127_1261111_1 FtsX-like permease family K02004 - - 2.462e-214 692.0
HFD2_k127_1261111_10 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007797 276.0
HFD2_k127_1261111_11 Class II Aldolase and Adducin N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001016 281.0
HFD2_k127_1261111_12 TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001612 287.0
HFD2_k127_1261111_13 Phenazine biosynthesis protein PhzF K06998 - 5.3.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000005624 267.0
HFD2_k127_1261111_14 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006933 274.0
HFD2_k127_1261111_15 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001198 254.0
HFD2_k127_1261111_16 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000004877 250.0
HFD2_k127_1261111_17 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000002188 235.0
HFD2_k127_1261111_18 Glycine zipper - - - 0.0000000000000000000000000000000000000000000000000004335 193.0
HFD2_k127_1261111_19 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000022 175.0
HFD2_k127_1261111_2 Amidohydrolase family - - - 8.771e-195 621.0
HFD2_k127_1261111_20 transport system periplasmic component K01989 - - 0.0000000000000000000000000000000001035 145.0
HFD2_k127_1261111_21 Protein of unknown function (DUF3568) - - - 0.000000000000000000000109 104.0
HFD2_k127_1261111_22 S4 RNA-binding domain - - - 0.0000000000000000000008904 97.0
HFD2_k127_1261111_23 Protein of unknown function (DUF3617) - - - 0.0000000000000000000124 104.0
HFD2_k127_1261111_24 Rubrerythrin - - - 0.00000000004744 70.0
HFD2_k127_1261111_25 Protein tyrosine kinase K11912,K12132 - 2.7.11.1 0.000000003819 68.0
HFD2_k127_1261111_3 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 573.0
HFD2_k127_1261111_4 Chitin synthase K14666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009331 467.0
HFD2_k127_1261111_5 Fungal trichothecene efflux pump (TRI12) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007052 472.0
HFD2_k127_1261111_6 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 407.0
HFD2_k127_1261111_7 Lipocalin-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000057 373.0
HFD2_k127_1261111_8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005632 341.0
HFD2_k127_1261111_9 Ketopantoate reductase K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000607 306.0
HFD2_k127_1317161_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 8.568e-235 737.0
HFD2_k127_1317161_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 4.345e-213 669.0
HFD2_k127_1332160_0 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000044 453.0
HFD2_k127_1332160_1 PFAM ATP-binding region, ATPase domain protein K02668 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000001143 243.0
HFD2_k127_1364520_0 PLD-like domain K06132 - - 3.079e-210 663.0
HFD2_k127_1364520_1 PFAM carboxyl transferase K01615 - 4.1.1.70 4.384e-206 649.0
HFD2_k127_1364520_10 Domain of unknown function (DUF4034) - - - 0.00000000000000000000000025 124.0
HFD2_k127_1364520_11 Biotin-requiring enzyme - - - 0.0000000000000000000174 93.0
HFD2_k127_1364520_12 - - - - 0.000000000000002511 80.0
HFD2_k127_1364520_13 Belongs to the UPF0301 (AlgH) family K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000001068 70.0
HFD2_k127_1364520_14 - K15383 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0016020,GO:0016021,GO:0031224,GO:0042802,GO:0044425 - 0.00007484 49.0
HFD2_k127_1364520_2 PFAM Acyl-CoA dehydrogenase K16173 - 1.3.99.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 563.0
HFD2_k127_1364520_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004136 379.0
HFD2_k127_1364520_4 Membrane protein TerC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000974 341.0
HFD2_k127_1364520_5 COG0563 Adenylate kinase and related kinases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009989 254.0
HFD2_k127_1364520_6 Bacterial protein of unknown function (DUF898) - - - 0.000000000000000000000000000000000000000000000000000000000000000002158 240.0
HFD2_k127_1364520_7 COG0501 Zn-dependent protease with chaperone function - - - 0.00000000000000000000000000000000000000000000000000000000000000281 248.0
HFD2_k127_1364520_8 2OG-Fe(II) oxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000002417 190.0
HFD2_k127_1364520_9 TspO/MBR family K05770 - - 0.0000000000000000000000000000000000004825 151.0
HFD2_k127_1369822_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1197.0
HFD2_k127_1369822_1 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 1.185e-274 862.0
HFD2_k127_1369822_10 Protein of unknown function (DUF3106) - - - 0.0000000000000000000000000894 116.0
HFD2_k127_1369822_11 RDD family - - - 0.00000000000000000000000354 109.0
HFD2_k127_1369822_12 Protein of unknown function (DUF3619) - - - 0.000000000000000006831 88.0
HFD2_k127_1369822_13 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0002247 54.0
HFD2_k127_1369822_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 592.0
HFD2_k127_1369822_3 Peptidase M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009114 436.0
HFD2_k127_1369822_4 Permease, YjgP YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003502 396.0
HFD2_k127_1369822_5 Permease YjgP YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006874 379.0
HFD2_k127_1369822_6 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000001017 259.0
HFD2_k127_1369822_7 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000000000000000000000000000000004343 236.0
HFD2_k127_1369822_8 Haem-degrading - - - 0.0000000000000000000000000000000000000000000000003644 182.0
HFD2_k127_1369822_9 dna polymerase III (Chi subunit) K02339 - 2.7.7.7 0.000000000000000000000000000000001466 149.0
HFD2_k127_1392934_0 xanthine dehydrogenase activity K04108 - 1.3.7.9 3.289e-203 647.0
HFD2_k127_1392934_1 ribosomal rna small subunit methyltransferase - - - 3.827e-200 633.0
HFD2_k127_1392934_10 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000001856 170.0
HFD2_k127_1392934_11 Domain of unknown function (DUF1330) - - - 0.0000000000000000000000000000000000001146 157.0
HFD2_k127_1392934_12 Transposase K07483 - - 0.000000000000000000000000009561 113.0
HFD2_k127_1392934_13 PFAM bifunctional deaminase-reductase domain protein - - - 0.00000000000001759 73.0
HFD2_k127_1392934_14 - - - - 0.00000000002082 70.0
HFD2_k127_1392934_15 - - - - 0.00000003508 60.0
HFD2_k127_1392934_2 Cystathionine beta-synthase K01697 - 4.2.1.22 1.289e-194 617.0
HFD2_k127_1392934_3 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01758 - 4.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006238 554.0
HFD2_k127_1392934_4 Aldo Keto reductase K05275 - 1.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 325.0
HFD2_k127_1392934_5 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009058 302.0
HFD2_k127_1392934_6 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000081 289.0
HFD2_k127_1392934_7 DDE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001082 274.0
HFD2_k127_1392934_8 Domain of Unknown Function (DUF1080) - - - 0.000000000000000000000000000000000000000000000000000000000000002065 223.0
HFD2_k127_1392934_9 COG0685 5,10-methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000003847 207.0
HFD2_k127_1404_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005812 315.0
HFD2_k127_1404_1 NUDIX domain - - - 0.000000000000000000000000000000000000000000002295 168.0
HFD2_k127_1404_2 HNH nucleases - - - 0.00000000000000000000000000000001852 134.0
HFD2_k127_1404_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K01768 - 4.6.1.1 0.0000000000000001329 87.0
HFD2_k127_1421212_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 617.0
HFD2_k127_1421212_1 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000009195 252.0
HFD2_k127_1421212_2 Glutathione S-transferase, C-terminal domain K07393 - 1.8.5.7 0.000000000000000000000000000000000000000000000000000000711 209.0
HFD2_k127_1421212_3 [2Fe-2S] binding domain K18029 - 1.17.2.1 0.0000000000000000000000000000000000000000000000002457 187.0
HFD2_k127_1421212_4 Glutathione S-transferase - - - 0.0000000000000000000000000000000000002163 152.0
HFD2_k127_1524879_0 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 7.947e-199 629.0
HFD2_k127_1524879_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 501.0
HFD2_k127_1524879_10 enzyme of heme biosynthesis K02496,K13543 - 2.1.1.107,4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000001733 271.0
HFD2_k127_1524879_11 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000000000000001138 254.0
HFD2_k127_1524879_12 PFAM Fructosamine - - - 0.0000000000000000000000000000000000000000000000000000000000000000001991 255.0
HFD2_k127_1524879_13 HemY domain protein K02498 - - 0.0000000000000000000000000000000000000000000000000000001957 207.0
HFD2_k127_1524879_14 Uroporphyrinogen-III synthase HemD - - - 0.00000000000000000000000000000000000000000000000001378 189.0
HFD2_k127_1524879_15 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000000000015 169.0
HFD2_k127_1524879_16 PFAM Cyclic nucleotide-binding - - - 0.0000000000000000000000000000000000002082 163.0
HFD2_k127_1524879_17 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000008315 132.0
HFD2_k127_1524879_18 EamA-like transporter family - - - 0.00000000000000000000000000002989 131.0
HFD2_k127_1524879_19 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00001781 58.0
HFD2_k127_1524879_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 511.0
HFD2_k127_1524879_3 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 461.0
HFD2_k127_1524879_4 Beta-ketoacyl synthase, C-terminal domain K09458,K14660 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008697 390.0
HFD2_k127_1524879_5 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009209 389.0
HFD2_k127_1524879_6 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007508 363.0
HFD2_k127_1524879_7 Histidine kinase K08082 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 297.0
HFD2_k127_1524879_8 Alginate biosynthesis regulatory protein AlgR K08083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002573 283.0
HFD2_k127_1524879_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009604 274.0
HFD2_k127_1582814_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009497 540.0
HFD2_k127_1582814_1 NADPH quinone oxidoreductase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004242 440.0
HFD2_k127_1582814_10 Protein of unknown function (DUF1499) - - - 0.000000000000000000000000000000004333 135.0
HFD2_k127_1582814_11 NMT1-like family - - - 0.00000000000000000000000000001153 130.0
HFD2_k127_1582814_12 alpha beta - - - 0.000000000000006846 87.0
HFD2_k127_1582814_13 Protein of unknown function (DUF2917) - - - 0.00006941 51.0
HFD2_k127_1582814_2 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 455.0
HFD2_k127_1582814_3 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 395.0
HFD2_k127_1582814_4 PFAM short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 398.0
HFD2_k127_1582814_5 Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006437 392.0
HFD2_k127_1582814_6 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008894 406.0
HFD2_k127_1582814_7 2-nitropropane dioxygenase K00459 GO:0000166,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0007623,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0012505,GO:0016192,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0032940,GO:0034404,GO:0034641,GO:0034654,GO:0034774,GO:0036094,GO:0036230,GO:0042119,GO:0042278,GO:0042451,GO:0042455,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046903,GO:0048511,GO:0050896,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0060205,GO:0070013,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097708,GO:0099503,GO:0101002,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1904813 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 307.0
HFD2_k127_1582814_8 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000287 280.0
HFD2_k127_1582814_9 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000004012 177.0
HFD2_k127_1586392_0 Protein of unknown function (DUF933) K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 535.0
HFD2_k127_1586392_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009293 497.0
HFD2_k127_1586392_10 cell division K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 295.0
HFD2_k127_1586392_11 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 317.0
HFD2_k127_1586392_12 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001208 248.0
HFD2_k127_1586392_13 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.000000000000000000000000000000000000000000000000000000000000000000004218 253.0
HFD2_k127_1586392_14 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000000003897 229.0
HFD2_k127_1586392_15 oxidase assembly K02258 - - 0.000000000000000000000000000000000000000000000000000000000000001383 224.0
HFD2_k127_1586392_16 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000000000000001445 223.0
HFD2_k127_1586392_17 Involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.0000000000000000000000000000000000000000000000000000000093 205.0
HFD2_k127_1586392_18 SURF1-like protein K14998 - - 0.0000000000000000000000000000000000000000000000001097 185.0
HFD2_k127_1586392_19 methyltransferase K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000006759 175.0
HFD2_k127_1586392_2 SMART Tetratricopeptide domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 453.0
HFD2_k127_1586392_20 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000001035 152.0
HFD2_k127_1586392_21 signal sequence binding - - - 0.00000000000000000000000000000000000003039 151.0
HFD2_k127_1586392_22 Outer membrane lipoprotein LolB - - - 0.000000000000000000000000002782 125.0
HFD2_k127_1586392_24 Protein of unknown function (DUF2970) - - - 0.0001136 53.0
HFD2_k127_1586392_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 404.0
HFD2_k127_1586392_4 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 398.0
HFD2_k127_1586392_5 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009871 397.0
HFD2_k127_1586392_6 RNA polymerase sigma K03089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005963 369.0
HFD2_k127_1586392_7 COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3 K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 364.0
HFD2_k127_1586392_8 Fatty acid desaturase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 303.0
HFD2_k127_1586392_9 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005757 312.0
HFD2_k127_1622069_0 PAS fold - - - 3.72e-208 669.0
HFD2_k127_1622069_1 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749,K14471,K14472 - 2.8.3.16,2.8.3.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 531.0
HFD2_k127_1622069_2 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000000000000001639 192.0
HFD2_k127_1622069_3 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000007359 184.0
HFD2_k127_1622069_4 PFAM Gp37Gp68 family protein - - - 0.000000000001381 69.0
HFD2_k127_1622069_5 Predicted membrane protein (DUF2243) - - - 0.0006089 44.0
HFD2_k127_1749768_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000504 385.0
HFD2_k127_1749768_1 Transcriptional regulatory protein, C terminal K07657 - - 0.000000000000000000000000000000000000000000000000000000000000006989 235.0
HFD2_k127_1749768_2 Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis K03411 - 3.5.1.44 0.0000000000000000000000000000000000000000000000000003097 198.0
HFD2_k127_1749768_3 Histidine kinase - - - 0.000000000000000000000000000000000000000236 168.0
HFD2_k127_1749768_4 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000000000000000000000006144 147.0
HFD2_k127_1749768_5 histidine kinase A domain protein - - - 0.0000000000000000000000000000002919 139.0
HFD2_k127_1749768_6 Chemotaxis protein CheY - - - 0.00000000000000000000000146 117.0
HFD2_k127_1749768_7 FOG HPt domain K20976 - - 0.00003848 52.0
HFD2_k127_1794443_0 PrkA AAA domain K07180 - - 1.114e-216 677.0
HFD2_k127_1794443_1 SpoVR like protein K06415 - - 4.556e-203 642.0
HFD2_k127_1794443_2 Protein of unknown function (DUF444) K09786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 434.0
HFD2_k127_1794443_3 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 350.0
HFD2_k127_1794443_4 PFAM conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001477 249.0
HFD2_k127_1794443_5 - - - - 0.00000001549 61.0
HFD2_k127_1817624_0 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 4.285e-217 715.0
HFD2_k127_1817624_1 PFAM monooxygenase FAD-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 340.0
HFD2_k127_1817624_2 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006571 281.0
HFD2_k127_1817624_3 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001445 300.0
HFD2_k127_1817624_4 PAS fold K02484 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000002419 253.0
HFD2_k127_1817624_5 protein histidine kinase activity - - - 0.0000000000000000004407 97.0
HFD2_k127_1817624_6 GAF domain - - - 0.0000000000001437 83.0
HFD2_k127_1817624_7 Polyphosphate kinase 2 (PPK2) K22468 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008976,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0044237 2.7.4.1 0.00007105 46.0
HFD2_k127_1830186_0 helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009523 477.0
HFD2_k127_1830186_1 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000007073 229.0
HFD2_k127_1830186_2 Sporulation related domain - - - 0.0000000000000000000000000000000000000000000000000000000006416 213.0
HFD2_k127_1830186_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.00002848 47.0
HFD2_k127_1835252_0 aminopeptidase N K01256 - 3.4.11.2 1.642e-304 953.0
HFD2_k127_1835252_1 Tetrapyrrole (Corrin/Porphyrin) Methylases K02303 - 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000002482 252.0
HFD2_k127_1835252_2 Formate/nitrite transporter K02598,K06212,K21993 - - 0.0000000000000000000000000000000000000117 154.0
HFD2_k127_1835252_3 Citrate transporter - - - 0.0000000000000000000000000000009306 138.0
HFD2_k127_1835252_4 Helix-turn-helix XRE-family like proteins K21498 - - 0.000000000000000000000000000001094 123.0
HFD2_k127_184325_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 1.794e-235 761.0
HFD2_k127_184325_1 GcpE protein K03526 - 1.17.7.1,1.17.7.3 7.456e-198 623.0
HFD2_k127_184325_10 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000001165 265.0
HFD2_k127_184325_11 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000002519 252.0
HFD2_k127_184325_12 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000000002042 240.0
HFD2_k127_184325_13 COG0477 Permeases of the major facilitator superfamily K05820 - - 0.00000000000000000000000000000000000000000000000000000000000000000006116 244.0
HFD2_k127_184325_14 type 4 pilus biogenesis protein K02656 - - 0.000000000000000000000000000000000000000000000000000000008495 221.0
HFD2_k127_184325_15 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000001241 203.0
HFD2_k127_184325_16 HNH endonuclease - - - 0.000000000000000000000000000000000000002283 148.0
HFD2_k127_184325_17 Domain of unknown function (DUF4115) K15539 - - 0.00000000000000000000000000000001125 141.0
HFD2_k127_184325_2 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006067 559.0
HFD2_k127_184325_3 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000378 519.0
HFD2_k127_184325_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009707 512.0
HFD2_k127_184325_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009922 393.0
HFD2_k127_184325_6 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003003 406.0
HFD2_k127_184325_7 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 340.0
HFD2_k127_184325_8 Peptidase M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 312.0
HFD2_k127_184325_9 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002682 291.0
HFD2_k127_1852900_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 3.494e-235 752.0
HFD2_k127_1852900_1 (ABC) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 327.0
HFD2_k127_1852900_2 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.000000000000000000000000000000000000000000000000000001291 194.0
HFD2_k127_1852900_3 Helix-hairpin-helix domain K04477 - - 0.000000000000000000000000000000000000002581 151.0
HFD2_k127_1852900_4 CoA-binding domain protein K09181 - - 0.00000000000000000000000000000000003705 144.0
HFD2_k127_1852900_5 Bacterial protein of unknown function (DUF883) - - - 0.000000000000000003328 88.0
HFD2_k127_1852900_6 PFAM Nitroreductase K04719,K19286 - 1.13.11.79,1.5.1.39 0.0000000000004482 76.0
HFD2_k127_1852900_7 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000000007842 63.0
HFD2_k127_1860882_0 DEAD/H associated K03724 - - 6.672e-258 807.0
HFD2_k127_1860882_1 ICC-like phosphoesterases K06953 - - 0.000000000000000000000000000000000000000000003186 171.0
HFD2_k127_191108_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 542.0
HFD2_k127_191108_1 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 392.0
HFD2_k127_191108_2 Pyruvate synthase K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002121 400.0
HFD2_k127_191108_3 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170,K19071 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006039 312.0
HFD2_k127_191108_4 domain protein K00528,K16951 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003951 276.0
HFD2_k127_191108_5 ferredoxin K00172 - 1.2.7.1 0.0000000000000000000000000000000000000001996 160.0
HFD2_k127_1927562_0 general L-amino acid-binding periplasmic protein AapJ K09969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 449.0
HFD2_k127_1927562_1 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000087 266.0
HFD2_k127_1927562_2 Gram-negative-bacterium-type cell wall biogenesis - GO:0000270,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0030203,GO:0031224,GO:0042546,GO:0043164,GO:0043170,GO:0044085,GO:0044425,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000004826 233.0
HFD2_k127_1927562_3 Predicted metal-dependent hydrolase K07044 - - 0.0000000000000000000000000000000000000000000000000000000001253 214.0
HFD2_k127_1927562_4 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000004111 50.0
HFD2_k127_1929708_0 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 495.0
HFD2_k127_1929708_1 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 473.0
HFD2_k127_1929708_2 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 427.0
HFD2_k127_1929708_3 branched-chain amino acid K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009723 349.0
HFD2_k127_1929708_4 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000003371 161.0
HFD2_k127_1958322_0 Transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 0.0 1277.0
HFD2_k127_1958322_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000006127 164.0
HFD2_k127_1972196_0 Tripartite tricarboxylate transporter TctA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 344.0
HFD2_k127_1972196_1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000006542 227.0
HFD2_k127_1972196_2 Tripartite tricarboxylate transporter TctB family - - - 0.000000000000000000000000000000000000000000000000003323 186.0
HFD2_k127_2022835_0 PFAM amidohydrolase K01464,K01466 - 3.5.2.2,3.5.2.5 7.301e-254 791.0
HFD2_k127_2022835_1 PFAM AMP-dependent synthetase and ligase K20034 - 6.2.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002593 618.0
HFD2_k127_2022835_10 PFAM ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000001385 236.0
HFD2_k127_2022835_11 Branched-chain amino acid ATP-binding cassette transporter K01995 GO:0003333,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015807,GO:0015808,GO:0015818,GO:0015829,GO:0015849,GO:0015893,GO:0032328,GO:0034220,GO:0042221,GO:0042493,GO:0042940,GO:0042941,GO:0043090,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903805,GO:1903806,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000006536 202.0
HFD2_k127_2022835_12 Domain of unknown function (DUF1330) - - - 0.00000000000000001258 86.0
HFD2_k127_2022835_13 Branched-chain amino acid transport system / permease component K01997,K01998 - - 0.000000000000004682 79.0
HFD2_k127_2022835_2 Cysteine synthase K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 504.0
HFD2_k127_2022835_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 487.0
HFD2_k127_2022835_4 FAD dependent oxidoreductase K00244 - 1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 479.0
HFD2_k127_2022835_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006408 443.0
HFD2_k127_2022835_6 Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 383.0
HFD2_k127_2022835_7 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 299.0
HFD2_k127_2022835_8 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002885 255.0
HFD2_k127_2022835_9 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003808 244.0
HFD2_k127_2032323_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1302.0
HFD2_k127_2032323_1 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 4.412e-225 717.0
HFD2_k127_2032323_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003696 467.0
HFD2_k127_2032323_3 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 463.0
HFD2_k127_2032323_4 Neisseria PilC beta-propeller domain K02674 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 359.0
HFD2_k127_2032323_5 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 306.0
HFD2_k127_2032323_6 SMART metal-dependent phosphohydrolase, HD region K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000001518 257.0
HFD2_k127_2032323_7 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001755 243.0
HFD2_k127_2032323_8 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000000000000003244 174.0
HFD2_k127_2051329_0 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 581.0
HFD2_k127_2051329_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 576.0
HFD2_k127_2051329_10 transport system fused permease components - - - 0.00000007278 55.0
HFD2_k127_2051329_11 Protein of unknown function (DUF2799) - - - 0.0000007086 54.0
HFD2_k127_2051329_12 Major facilitator superfamily - - - 0.000003812 59.0
HFD2_k127_2051329_13 Protein of unknown function (DUF2799) - - - 0.00008333 51.0
HFD2_k127_2051329_14 DNA-sulfur modification-associated - - - 0.00009233 54.0
HFD2_k127_2051329_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 557.0
HFD2_k127_2051329_3 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003691 505.0
HFD2_k127_2051329_4 C-terminal region of band_7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009917 397.0
HFD2_k127_2051329_5 dUTPase K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 347.0
HFD2_k127_2051329_6 2-Keto-4-pentenoate hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002767 246.0
HFD2_k127_2051329_7 Protein of unknown function (DUF1223) - - - 0.000000000000000000000000000000000000000000000000000000001638 213.0
HFD2_k127_2051329_8 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.000000000000000000000000000000000000000000000000000001191 196.0
HFD2_k127_2051329_9 NfeD-like C-terminal, partner-binding - - - 0.000000002353 65.0
HFD2_k127_2137871_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 533.0
HFD2_k127_2137871_1 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003124 276.0
HFD2_k127_2137871_2 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000001459 206.0
HFD2_k127_2141091_0 Required for chromosome condensation and partitioning K03529 - - 6.672e-292 931.0
HFD2_k127_2141091_1 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007095 494.0
HFD2_k127_2141091_11 - - - - 0.0001425 55.0
HFD2_k127_2141091_2 Aminotransferase class I and II K14267 - 2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 501.0
HFD2_k127_2141091_3 twitching motility protein K02670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007121 469.0
HFD2_k127_2141091_4 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007202 423.0
HFD2_k127_2141091_5 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 305.0
HFD2_k127_2141091_6 Belongs to the protein N5-glutamine methyltransferase family K07320 - 2.1.1.298 0.00000000000000000000000000000000000000000000000000000000000000000001131 250.0
HFD2_k127_2141091_7 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000000000000000000000000000000000000000001265 230.0
HFD2_k127_2141091_8 PFAM CHAD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000001169 233.0
HFD2_k127_2141091_9 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000001299 202.0
HFD2_k127_2144177_0 AMP-binding enzyme C-terminal domain - - - 1.657e-248 790.0
HFD2_k127_2144177_1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005416 560.0
HFD2_k127_2144177_10 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 379.0
HFD2_k127_2144177_11 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004026 354.0
HFD2_k127_2144177_12 dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 341.0
HFD2_k127_2144177_13 Dioxygenases related to 2-nitropropane dioxygenase K00459,K02371 - 1.13.12.16,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 352.0
HFD2_k127_2144177_14 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 343.0
HFD2_k127_2144177_15 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003671 327.0
HFD2_k127_2144177_16 ABC transporter, phosphonate, periplasmic substrate-binding protein K02051,K15553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 314.0
HFD2_k127_2144177_17 Belongs to the enoyl-CoA hydratase isomerase family K01692,K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005686 278.0
HFD2_k127_2144177_18 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001647 277.0
HFD2_k127_2144177_19 Bacterial extracellular solute-binding protein, family 7 K21395 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000697 275.0
HFD2_k127_2144177_2 III protein, CoA-transferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006477 546.0
HFD2_k127_2144177_20 4,5-dihydroxyphthalate decarboxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008215 268.0
HFD2_k127_2144177_21 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002558 271.0
HFD2_k127_2144177_22 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006428 264.0
HFD2_k127_2144177_23 protocatechuate 3,4-dioxygenase, beta subunit K00449 - 1.13.11.3 0.00000000000000000000000000000000000000000000000000000000000005824 220.0
HFD2_k127_2144177_24 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000004791 139.0
HFD2_k127_2144177_25 protocatechuate 3,4-dioxygenase K00448 - 1.13.11.3 0.000000000000000000000000000000001907 146.0
HFD2_k127_2144177_26 Ndr family K01055,K14727 - 3.1.1.24,4.1.1.44 0.000000000000000000000000008058 127.0
HFD2_k127_2144177_27 Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols K04099,K04101 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0036238,GO:0042537,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 1.13.11.57,1.13.11.8 0.0000000000000000002154 102.0
HFD2_k127_2144177_28 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000007083 87.0
HFD2_k127_2144177_29 EamA-like transporter family - - - 0.0000000003902 73.0
HFD2_k127_2144177_3 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 523.0
HFD2_k127_2144177_4 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 483.0
HFD2_k127_2144177_5 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component K11690 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007916 492.0
HFD2_k127_2144177_6 HMGL-like K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004259 445.0
HFD2_k127_2144177_7 PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B K04101 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 411.0
HFD2_k127_2144177_8 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 407.0
HFD2_k127_2144177_9 ATPases associated with a variety of cellular activities K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 362.0
HFD2_k127_2146449_0 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006949 407.0
HFD2_k127_2146449_1 (ABC) transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 351.0
HFD2_k127_2146449_2 Cupin 2, conserved barrel - - - 0.000000000000000000000000000000000000000000000000000001123 200.0
HFD2_k127_2146449_3 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000009059 192.0
HFD2_k127_2146449_4 response regulator - - - 0.000000000000000000000000000000000008724 145.0
HFD2_k127_2146449_5 PFAM conserved - - - 0.00000000000000000000000000000003196 129.0
HFD2_k127_2146449_6 SMART Cold shock protein K03704 - - 0.00000000000000000000000000001088 118.0
HFD2_k127_2146449_7 - - - - 0.0000035 58.0
HFD2_k127_2168963_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0 1032.0
HFD2_k127_2168963_1 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 542.0
HFD2_k127_2168963_2 coenzyme F390 K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007581 402.0
HFD2_k127_2168963_3 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 319.0
HFD2_k127_2168963_4 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000002264 252.0
HFD2_k127_2168963_5 [2Fe-2S] binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002047 229.0
HFD2_k127_2168963_6 - - - - 0.000000000000000000000000000000000000000000000000001231 194.0
HFD2_k127_2190947_0 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 494.0
HFD2_k127_2190947_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 344.0
HFD2_k127_2190947_2 Nodulation protein S (NodS) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 310.0
HFD2_k127_2190947_3 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000002837 125.0
HFD2_k127_2236982_0 ATP-binding cassette protein, ChvD family K06020 - 3.6.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005908 558.0
HFD2_k127_2236982_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 512.0
HFD2_k127_2236982_2 Transposase IS200 like K07491 - - 0.000000000000000000000000000000000000000000000000000000006462 225.0
HFD2_k127_2236982_3 Glucose dehydrogenase C-terminus - - - 0.00000000000000000000000000000000000000001581 156.0
HFD2_k127_2274311_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 4.246e-210 660.0
HFD2_k127_2274311_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000007253 186.0
HFD2_k127_2275283_0 belongs to the bacterial solute-binding protein 3 family K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009741 474.0
HFD2_k127_2275283_1 polar amino acid transport system K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 372.0
HFD2_k127_2275283_2 Asp/Glu/Hydantoin racemase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 308.0
HFD2_k127_2275283_3 Flavin reductase like domain - - - 0.0007058 43.0
HFD2_k127_2281693_0 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 372.0
HFD2_k127_2281693_1 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000561 329.0
HFD2_k127_2281693_10 Ring hydroxylating subunit beta family protein 1 - - - 0.00000000000000000000000002389 114.0
HFD2_k127_2281693_11 helix_turn_helix, Lux Regulon K07684,K07693 - - 0.0000000000008578 75.0
HFD2_k127_2281693_2 Belongs to the HpcH HpaI aldolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 314.0
HFD2_k127_2281693_3 protein deglycase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005547 249.0
HFD2_k127_2281693_4 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000001032 225.0
HFD2_k127_2281693_5 thiamine-containing compound biosynthetic process K02051,K15553 - - 0.0000000000000000000000000000000000000000000000000000000000001019 224.0
HFD2_k127_2281693_6 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component - - - 0.000000000000000000000000000000000000000000000000000000004114 218.0
HFD2_k127_2281693_7 Evidence 4 Homologs of previously reported genes of K09700 - - 0.00000000000000000000000000000000000000000000000002218 182.0
HFD2_k127_2281693_8 COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050 - - 0.00000000000000000000000000000000000000000005075 174.0
HFD2_k127_2281693_9 Rieske 2Fe-2S domain protein - - - 0.00000000000000000000000000000000000006655 146.0
HFD2_k127_2289904_0 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 449.0
HFD2_k127_2289904_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 340.0
HFD2_k127_2289904_2 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000002087 233.0
HFD2_k127_2289904_3 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.000000000000000115 82.0
HFD2_k127_2313865_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K11747 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007505 538.0
HFD2_k127_2313865_1 - - - - 0.000000000000000000000000000000000000000000000000000486 191.0
HFD2_k127_2313865_2 Flavin reductase like domain K00484 - 1.5.1.36 0.0000000000000000000000000000000009727 138.0
HFD2_k127_2313865_3 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000009717 77.0
HFD2_k127_2313865_4 Major Facilitator Superfamily - - - 0.00000000000008566 85.0
HFD2_k127_2357009_0 PAS fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 488.0
HFD2_k127_2357009_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 366.0
HFD2_k127_2357009_2 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001221 278.0
HFD2_k127_2357009_3 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.0000000000000000000000000000000000000000000003609 169.0
HFD2_k127_2357009_4 - - - - 0.0000000000000000000000003922 117.0
HFD2_k127_2357009_5 Protein of unknown function (DUF3301) - - - 0.000000000000000000001141 98.0
HFD2_k127_2371405_0 glycolate oxidase iron-sulfur subunit K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002895 554.0
HFD2_k127_2371405_1 PFAM FAD linked oxidase domain protein K00102,K00104,K03777 - 1.1.2.4,1.1.3.15,1.1.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 510.0
HFD2_k127_2371405_2 FAD binding domain K11472 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 403.0
HFD2_k127_2371405_3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000002471 183.0
HFD2_k127_2418226_0 ornithine cyclodeaminase K01750 - 4.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 522.0
HFD2_k127_2418226_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 428.0
HFD2_k127_2418226_2 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K05712 - 1.14.13.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 386.0
HFD2_k127_2418226_3 C-terminal domain of 1-Cys peroxiredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 311.0
HFD2_k127_2418226_4 proline dipeptidase activity K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 321.0
HFD2_k127_2418226_5 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 289.0
HFD2_k127_2418226_6 Glycine-zipper domain - - - 0.000000000000000000000000000000000003452 154.0
HFD2_k127_2418226_7 Calcium/calmodulin dependent protein kinase II association domain - - - 0.0000000000756 66.0
HFD2_k127_2469897_0 twitching motility protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 588.0
HFD2_k127_2469897_1 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 - 2.7.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004992 484.0
HFD2_k127_2469897_2 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000912 249.0
HFD2_k127_2469897_3 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000009292 255.0
HFD2_k127_2469897_4 integral membrane protein K02221 - - 0.000000000000000000000000000000000000006029 153.0
HFD2_k127_2469897_5 Belongs to the UPF0235 family K09131 - - 0.00000000000000003797 91.0
HFD2_k127_2469897_6 membrane - - - 0.0000000001631 65.0
HFD2_k127_2484944_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.0 1012.0
HFD2_k127_2484944_1 glutamine synthetase K01915,K20712 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 1.107e-244 763.0
HFD2_k127_2484944_10 rhodanese-related sulfurtransferase - - - 0.000000000000000000000000000000000002155 140.0
HFD2_k127_2484944_11 Glycosyl transferase family 2 - - - 0.00000000000000000003323 93.0
HFD2_k127_2484944_12 Domain of unknown function (DUF4124) - - - 0.0006574 46.0
HFD2_k127_2484944_2 type I secretion outer membrane protein, TolC K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004075 442.0
HFD2_k127_2484944_3 3-Deoxy-D-manno-octulosonic-acid transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008222 381.0
HFD2_k127_2484944_4 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 326.0
HFD2_k127_2484944_5 PFAM Metal-dependent phosphohydrolase, HD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 317.0
HFD2_k127_2484944_6 Glycosyltransferase family 9 (heptosyltransferase) K02841 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 308.0
HFD2_k127_2484944_7 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001259 279.0
HFD2_k127_2484944_8 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000001848 190.0
HFD2_k127_2484944_9 alpha beta - - - 0.000000000000000000000000000000000000000000000000003223 191.0
HFD2_k127_2548932_0 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000418 578.0
HFD2_k127_2548932_1 Cobalamin-independent synthase, Catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 480.0
HFD2_k127_2548932_10 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - 0.000000000000000000000002836 111.0
HFD2_k127_2548932_11 membrane - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000005145 100.0
HFD2_k127_2548932_12 - - - - 0.0000000000007383 74.0
HFD2_k127_2548932_2 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002997 434.0
HFD2_k127_2548932_3 Belongs to the binding-protein-dependent transport system permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 411.0
HFD2_k127_2548932_4 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 376.0
HFD2_k127_2548932_5 ATPases associated with a variety of cellular activities K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004614 352.0
HFD2_k127_2548932_6 Branched-chain amino acid ATP-binding cassette transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 328.0
HFD2_k127_2548932_7 mandelate racemase muconate lactonizing K01781 - 5.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000005469 238.0
HFD2_k127_2548932_8 - - - - 0.000000000000000000000000000000000000000000000000000007088 198.0
HFD2_k127_2548932_9 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000001163 170.0
HFD2_k127_2556371_0 Domain of unknown function (DUF4445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 594.0
HFD2_k127_2556371_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007642 304.0
HFD2_k127_2556371_2 Pterin binding enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 293.0
HFD2_k127_2556371_3 PFAM Uroporphyrinogen decarboxylase (URO-D) - - - 0.000000000000000000000000000000000000000000000000000000000001248 211.0
HFD2_k127_2556371_4 methionine synthase K00548 - 2.1.1.13 0.000000000000006788 85.0
HFD2_k127_2556371_5 Pterin binding enzyme - - - 0.000002335 49.0
HFD2_k127_2561821_0 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.0 1071.0
HFD2_k127_2561821_1 PLD-like domain - - - 3.271e-247 775.0
HFD2_k127_2561821_2 Bifunctional enoyl-CoA hydratase phosphate acetyltransferase K00625 - 2.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 385.0
HFD2_k127_2561821_3 NAD NADP octopine nopaline dehydrogenase K04940 - 1.5.1.28 0.0000000000000000000000000000000000000000000003147 169.0
HFD2_k127_2561821_4 - - - - 0.000000000000000001378 89.0
HFD2_k127_2564566_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 1.643e-237 751.0
HFD2_k127_2564566_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 1.084e-211 675.0
HFD2_k127_2564566_2 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0000000000000000000000000000001348 125.0
HFD2_k127_25861_0 CoA binding domain K09181 - - 1.085e-273 869.0
HFD2_k127_25861_1 Heavy-metal-associated domain K01533 - 3.6.3.4 7.772e-201 656.0
HFD2_k127_25861_10 Protein of unknown function (DUF3096) - - - 0.00000001634 57.0
HFD2_k127_25861_2 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005767 445.0
HFD2_k127_25861_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 325.0
HFD2_k127_25861_4 Belongs to the heme-copper respiratory oxidase family K00404 GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 297.0
HFD2_k127_25861_5 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001751 255.0
HFD2_k127_25861_6 Cysteine-rich domain - - - 0.0000000000000000000000000000000000000000000000001452 177.0
HFD2_k127_25861_7 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000005659 139.0
HFD2_k127_25861_8 Universal stress protein - - - 0.0000000000000000000000000000000001033 155.0
HFD2_k127_25861_9 cytochrome oxidase maturation protein cbb3-type - - - 0.0000000003478 70.0
HFD2_k127_258901_0 Exonuclease VII, large subunit K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 385.0
HFD2_k127_258901_1 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 308.0
HFD2_k127_258901_10 phosphorelay signal transduction system K07667 - - 0.0000000000181 74.0
HFD2_k127_258901_2 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007883 287.0
HFD2_k127_258901_3 MotA/TolQ/ExbB proton channel family K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003299 280.0
HFD2_k127_258901_4 Cobalamin adenosyltransferase K00798 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000002475 231.0
HFD2_k127_258901_5 oxidation-reduction process - - - 0.000000000000000000000000000000000000000000000002764 177.0
HFD2_k127_258901_6 Biopolymer transport protein ExbD TolR K03559 - - 0.0000000000000000000000000000000000000000121 156.0
HFD2_k127_258901_7 protein conserved in bacteria K07793 - - 0.000000000000000000000000054 108.0
HFD2_k127_258901_8 Belongs to the UPF0434 family K09791 - - 0.0000000000000000001545 90.0
HFD2_k127_258901_9 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.00000000000000001236 82.0
HFD2_k127_2619860_0 Pyridine nucleotide-disulphide oxidoreductase - - - 1.701e-289 897.0
HFD2_k127_2619860_1 Cytochrome c K02198 - - 9.11e-282 879.0
HFD2_k127_2619860_10 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 368.0
HFD2_k127_2619860_11 Histidine kinase K10125 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 301.0
HFD2_k127_2619860_12 Cytochrome c-type biogenesis protein K02200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002611 299.0
HFD2_k127_2619860_13 Pyruvate ferredoxin/flavodoxin oxidoreductase K18357 - 1.2.1.58 0.000000000000000000000000000000000000000000000000000000000000000000000000000001979 270.0
HFD2_k127_2619860_14 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002101 268.0
HFD2_k127_2619860_15 Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002403 252.0
HFD2_k127_2619860_16 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000002611 240.0
HFD2_k127_2619860_17 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000000000000000000000000000000000005613 201.0
HFD2_k127_2619860_18 Redoxin K02199 - - 0.000000000000000000000000000000000000000000000000000000008224 224.0
HFD2_k127_2619860_19 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000000000000000000008342 192.0
HFD2_k127_2619860_2 TRAP transporter, 4TM 12TM fusion protein - - - 2.209e-245 775.0
HFD2_k127_2619860_20 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000002789 207.0
HFD2_k127_2619860_21 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.000000000000000000000000000000000000000001276 167.0
HFD2_k127_2619860_22 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000000000004092 158.0
HFD2_k127_2619860_23 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000002506 125.0
HFD2_k127_2619860_24 Universal stress protein - - - 0.000000000000000000006758 93.0
HFD2_k127_2619860_25 - - - - 0.0000000342 65.0
HFD2_k127_2619860_26 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - 0.000003333 58.0
HFD2_k127_2619860_3 Ethylbenzene dehydrogenase - - - 1.409e-217 682.0
HFD2_k127_2619860_4 Cysteine-rich domain - - - 5.532e-214 671.0
HFD2_k127_2619860_5 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004517 605.0
HFD2_k127_2619860_6 Pyruvate:ferredoxin oxidoreductase core domain II K18355 - 1.2.1.58 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004971 605.0
HFD2_k127_2619860_7 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K18356 - 1.2.1.58 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 510.0
HFD2_k127_2619860_8 amino acid transport system, ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 421.0
HFD2_k127_2619860_9 TRAP transporter, solute receptor (TAXI family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 372.0
HFD2_k127_263721_0 Glycosyl transferase family 41 - - - 0.00000000000000000000000000000000000000000000000000653 194.0
HFD2_k127_263721_1 Tetratricopeptide repeat - - - 0.0000000000000000000000000000003701 140.0
HFD2_k127_2655177_0 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 597.0
HFD2_k127_2655177_1 Vitamin k epoxide reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003258 277.0
HFD2_k127_2655177_2 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000004646 158.0
HFD2_k127_2655177_3 Pfam:DUF59 - - - 0.000000000000000000000000000009136 121.0
HFD2_k127_2664623_0 Pyruvate ferredoxin/flavodoxin oxidoreductase K04090 - 1.2.7.8 0.0 1603.0
HFD2_k127_2664623_1 Outer membrane usher protein K07347 - - 2.404e-282 890.0
HFD2_k127_2664623_10 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000002162 216.0
HFD2_k127_2664623_11 Spore Coat Protein U domain - - - 0.00000000000000000000000000000000000000000000000003069 190.0
HFD2_k127_2664623_12 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000002564 164.0
HFD2_k127_2664623_13 lactoylglutathione lyase activity K08234 - - 0.00000000000000000000000000000001064 135.0
HFD2_k127_2664623_14 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000002452 73.0
HFD2_k127_2664623_15 Spore Coat Protein U domain - - - 0.0002032 51.0
HFD2_k127_2664623_2 General secretory system II protein E domain protein K02454,K02652,K12276 - - 4.215e-240 759.0
HFD2_k127_2664623_3 4-Hydroxyphenylpyruvate dioxygenase K00457 - 1.13.11.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003638 549.0
HFD2_k127_2664623_4 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 354.0
HFD2_k127_2664623_5 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 293.0
HFD2_k127_2664623_6 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008988 286.0
HFD2_k127_2664623_7 Pili and flagellar-assembly chaperone, PapD N-terminal domain K07346 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009652 272.0
HFD2_k127_2664623_8 Type II secretion system (T2SS), protein F K02455,K12278 - - 0.00000000000000000000000000000000000000000000000000000000000000000161 254.0
HFD2_k127_2664623_9 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000007242 214.0
HFD2_k127_2691910_0 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 614.0
HFD2_k127_2691910_1 Belongs to the GPI family K01810 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009656 452.0
HFD2_k127_2691910_10 Evidence 4 Homologs of previously reported genes of - - - 0.000000000000000004837 86.0
HFD2_k127_2691910_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 367.0
HFD2_k127_2691910_3 Helix-turn-helix type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008034 354.0
HFD2_k127_2691910_4 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008631 326.0
HFD2_k127_2691910_5 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 312.0
HFD2_k127_2691910_6 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.00000000000000000000000000000000000000000000000000000000001257 211.0
HFD2_k127_2691910_7 Sel1 domain protein repeat-containing protein K07126 - - 0.0000000000000000000000000000000000000000000000000000001405 222.0
HFD2_k127_2691910_8 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K03520 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000004487 195.0
HFD2_k127_2691910_9 PFAM ribosomal protein L31 K02909 - - 0.00000000000000000000000003724 119.0
HFD2_k127_2695694_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 2.124e-273 855.0
HFD2_k127_2695694_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 1.411e-257 812.0
HFD2_k127_2695694_10 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 452.0
HFD2_k127_2695694_11 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 430.0
HFD2_k127_2695694_12 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006902 419.0
HFD2_k127_2695694_13 HD domain K13815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005707 411.0
HFD2_k127_2695694_14 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007097 406.0
HFD2_k127_2695694_15 COG0765 ABC-type amino acid transport system, permease component K09971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004068 421.0
HFD2_k127_2695694_16 PFAM aminotransferase, class I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 387.0
HFD2_k127_2695694_17 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007188 377.0
HFD2_k127_2695694_18 acid transport system permease K09970 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002299 346.0
HFD2_k127_2695694_19 Nicotinamidase K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003744 316.0
HFD2_k127_2695694_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 1.233e-252 792.0
HFD2_k127_2695694_20 Pfam Enoyl-CoA hydratase isomerase K13816 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 312.0
HFD2_k127_2695694_21 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009 318.0
HFD2_k127_2695694_22 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002578 296.0
HFD2_k127_2695694_23 Uracil DNA glycosylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001804 279.0
HFD2_k127_2695694_24 Deoxynucleoside kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004297 284.0
HFD2_k127_2695694_25 Belongs to the MtfA family K09933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000252 284.0
HFD2_k127_2695694_26 COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009408 263.0
HFD2_k127_2695694_27 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000002009 237.0
HFD2_k127_2695694_28 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000001164 237.0
HFD2_k127_2695694_29 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000005188 216.0
HFD2_k127_2695694_3 Belongs to the TPP enzyme family K01652 - 2.2.1.6 1.132e-217 717.0
HFD2_k127_2695694_30 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) - - - 0.00000000000000000000000000000000000000000000001211 178.0
HFD2_k127_2695694_31 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.00000000000000000000000000000000000000000001108 187.0
HFD2_k127_2695694_32 Belongs to the DnaA family K10763 - - 0.00000000000000000000000000000000000000000009222 168.0
HFD2_k127_2695694_33 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000001298 164.0
HFD2_k127_2695694_34 Preprotein translocase, YajC subunit K03210 - - 0.000000000000000000000000000000000000001034 149.0
HFD2_k127_2695694_35 Transcriptional regulator - - - 0.0000000000001832 85.0
HFD2_k127_2695694_4 O-methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000434 619.0
HFD2_k127_2695694_5 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000852 584.0
HFD2_k127_2695694_6 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004061 556.0
HFD2_k127_2695694_7 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 537.0
HFD2_k127_2695694_8 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009568 532.0
HFD2_k127_2695694_9 Histidine Phosphotransfer domain K10715 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 540.0
HFD2_k127_2718670_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1089.0
HFD2_k127_2718670_1 Translation, ribosomal structure and biogenesis K08301 - - 4.299e-219 700.0
HFD2_k127_2718670_10 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.0000000000000000000000000000000005838 150.0
HFD2_k127_2718670_11 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000001049 145.0
HFD2_k127_2718670_2 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 585.0
HFD2_k127_2718670_3 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007097 537.0
HFD2_k127_2718670_4 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 438.0
HFD2_k127_2718670_5 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 426.0
HFD2_k127_2718670_6 DNA polymerase III K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 296.0
HFD2_k127_2718670_7 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000000003917 215.0
HFD2_k127_2718670_8 COG3245 Cytochrome c5 - - - 0.0000000000000000000000000000000000000000000000000000000004861 212.0
HFD2_k127_2718670_9 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000000000000003745 160.0
HFD2_k127_2736884_0 Transport of potassium into the cell K03549 - - 1.261e-213 672.0
HFD2_k127_2736884_1 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 450.0
HFD2_k127_2736884_2 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001443 270.0
HFD2_k127_2736884_3 aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001152 268.0
HFD2_k127_2736884_4 Domain of unknown function (DUF4337) - - - 0.000000000000000000000000000000000000000000000000002772 187.0
HFD2_k127_2736884_5 Histidine kinase K14986 - 2.7.13.3 0.00000446 57.0
HFD2_k127_275706_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.327e-232 724.0
HFD2_k127_275706_1 Peptidase family M48 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004336 283.0
HFD2_k127_2764472_0 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 327.0
HFD2_k127_2764472_1 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008512 277.0
HFD2_k127_2764472_2 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182,K16874 - 4.1.1.98 0.000000000000000000000000000000000000000000000000000001165 199.0
HFD2_k127_2764472_3 Pfam:Pyridox_oxidase K09979 - - 0.00000000000000000000000000000000475 132.0
HFD2_k127_2788862_0 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 527.0
HFD2_k127_2788862_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 379.0
HFD2_k127_2788862_2 PFAM conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 317.0
HFD2_k127_2788862_3 COG2513 PEP phosphonomutase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000001443 211.0
HFD2_k127_2788862_4 Hydantoin racemase K16841 - 5.1.99.3 0.000000000000000000000000000000000000000000000000001486 193.0
HFD2_k127_2788862_5 Lactoylglutathione lyase - - - 0.00000000000000000000000000000000000307 141.0
HFD2_k127_2788862_6 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000001626 133.0
HFD2_k127_2788862_7 Asparaginase K01424 - 3.5.1.1 0.0000000000000000000000000006076 116.0
HFD2_k127_2788862_8 - - - - 0.000000000000001832 80.0
HFD2_k127_2796129_0 Aminoacyl tRNA synthetase class II, N-terminal domain K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006542 397.0
HFD2_k127_2796129_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000005387 263.0
HFD2_k127_2796129_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000000002051 201.0
HFD2_k127_2796129_3 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000001253 133.0
HFD2_k127_2796129_4 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0002187 46.0
HFD2_k127_2810845_0 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 6.194e-236 748.0
HFD2_k127_2810845_1 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000009415 190.0
HFD2_k127_2822603_0 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 528.0
HFD2_k127_2822603_1 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000965 357.0
HFD2_k127_2822603_2 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000229 168.0
HFD2_k127_2822603_3 Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily K01661,K07536 - 4.1.3.36 0.00000000000000000000000000000000000008587 142.0
HFD2_k127_2855075_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 1.015e-282 883.0
HFD2_k127_2855075_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 3.573e-201 640.0
HFD2_k127_2855075_10 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000002573 210.0
HFD2_k127_2855075_11 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.00000000000000000000000000000000000000000000000000000003704 204.0
HFD2_k127_2855075_12 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000000000000000000003422 183.0
HFD2_k127_2855075_13 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 - - 0.000000000000000000000000000000000000000000001022 175.0
HFD2_k127_2855075_14 - - - - 0.00000000000000000000000000000000000000000001209 169.0
HFD2_k127_2855075_15 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000002183 173.0
HFD2_k127_2855075_16 Ferredoxin, 2Fe-2S type, ISC system K04755 - - 0.0000000000000000000000000000000000000000754 173.0
HFD2_k127_2855075_17 PFAM Appr-1-p processing domain protein - - - 0.000000000000000000000000000000001882 138.0
HFD2_k127_2855075_18 FeS assembly protein IscX - - - 0.000000000000000000000001603 110.0
HFD2_k127_2855075_19 BolA-like protein K05527 - - 0.000000000000000000004598 103.0
HFD2_k127_2855075_2 AMP-binding enzyme K12508 - 6.2.1.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 532.0
HFD2_k127_2855075_20 - - - - 0.00000000000003459 74.0
HFD2_k127_2855075_21 - - - - 0.00003261 50.0
HFD2_k127_2855075_3 TIGRFAM Serine O-acetyltransferase K00640 - 2.3.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006437 304.0
HFD2_k127_2855075_4 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009761 303.0
HFD2_k127_2855075_5 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000004377 262.0
HFD2_k127_2855075_6 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.000000000000000000000000000000000000000000000000000000000000000000005525 236.0
HFD2_k127_2855075_7 probably involved in intracellular septation K06190 - - 0.00000000000000000000000000000000000000000000000000000000000000006376 226.0
HFD2_k127_2855075_8 Rrf2 family transcriptional regulator, iron-sulfur cluster assembly K13643 - - 0.0000000000000000000000000000000000000000000000000000000000000004228 223.0
HFD2_k127_2855075_9 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000006193 222.0
HFD2_k127_2857219_0 3-keto-5-aminohexanoate cleavage protein K18013 - 2.3.1.247 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004514 496.0
HFD2_k127_2857219_1 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 378.0
HFD2_k127_2857219_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 290.0
HFD2_k127_2857219_3 Transcriptional regulator, MarR family - - - 0.00000000000000000000000000000000000000000000000000000003323 203.0
HFD2_k127_2857219_4 BON domain - - - 0.0000000000000000000000000000000000000000244 158.0
HFD2_k127_2857219_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046 - 1.1.1.69 0.0000000000003999 71.0
HFD2_k127_2857667_0 Belongs to the TPP enzyme family K01576 - 4.1.1.7 6.373e-194 620.0
HFD2_k127_2857667_1 Receptor family ligand binding region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 586.0
HFD2_k127_2857667_10 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000003322 235.0
HFD2_k127_2857667_11 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000009649 190.0
HFD2_k127_2857667_12 - - - - 0.000000000000000000000000000000000000000003326 174.0
HFD2_k127_2857667_13 carbon monoxide dehydrogenase subunit G K09386 - - 0.0000000000000000000000000000000000000002645 155.0
HFD2_k127_2857667_14 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0000000000000000000000000000000001275 143.0
HFD2_k127_2857667_15 Domain of unknown function (DUF1330) - - - 0.0000000000000000000000000000001657 135.0
HFD2_k127_2857667_16 pfam nlp p60 K13695 - - 0.0000000000000000000000000000005739 130.0
HFD2_k127_2857667_17 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000005054 119.0
HFD2_k127_2857667_18 Belongs to the UPF0337 (CsbD) family - - - 0.000000000000054 76.0
HFD2_k127_2857667_19 - - - - 0.000004342 55.0
HFD2_k127_2857667_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 465.0
HFD2_k127_2857667_3 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 412.0
HFD2_k127_2857667_4 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 394.0
HFD2_k127_2857667_5 ATPases associated with a variety of cellular activities K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 312.0
HFD2_k127_2857667_6 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000055 288.0
HFD2_k127_2857667_7 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001961 291.0
HFD2_k127_2857667_8 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001303 267.0
HFD2_k127_2857667_9 Branched-chain amino acid ABC transporter, ATP-binding protein K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006678 246.0
HFD2_k127_2888924_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 3.66e-218 682.0
HFD2_k127_2888924_1 Histidine kinase-like ATPases - - - 0.000000000000000000001534 110.0
HFD2_k127_2893318_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1421.0
HFD2_k127_2893318_1 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 1.109e-237 749.0
HFD2_k127_2893318_10 Belongs to the SOS response-associated peptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001518 239.0
HFD2_k127_2893318_11 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K03438,K13292 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009249,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000002437 238.0
HFD2_k127_2893318_12 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000001267 127.0
HFD2_k127_2893318_13 - - - - 0.00000000000000000000002518 113.0
HFD2_k127_2893318_15 - - - - 0.00000000000504 70.0
HFD2_k127_2893318_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0000183,GO:0001302,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007568,GO:0007569,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0016874,GO:0016879,GO:0018130,GO:0019219,GO:0019222,GO:0019357,GO:0019358,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032502,GO:0034641,GO:0034654,GO:0040029,GO:0043094,GO:0043173,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046497,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0051276,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008037 595.0
HFD2_k127_2893318_3 Extracellular liganD-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 561.0
HFD2_k127_2893318_4 Permeases of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 410.0
HFD2_k127_2893318_5 Acetyl-CoA hydrolase/transferase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 394.0
HFD2_k127_2893318_6 Dimerisation domain of Zinc Transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 352.0
HFD2_k127_2893318_7 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 324.0
HFD2_k127_2893318_8 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001532 259.0
HFD2_k127_2893318_9 NADH dehydrogenase NAD(P)H nitroreductase K09019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002189 251.0
HFD2_k127_2910319_0 PFAM nitrite and sulphite reductase 4Fe-4S K00366 - 1.7.7.1 3.866e-208 669.0
HFD2_k127_2910319_1 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 556.0
HFD2_k127_2910319_2 Oxidoreductase NAD-binding domain K00380,K02641,K14338 - 1.14.14.1,1.18.1.2,1.6.2.4,1.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 496.0
HFD2_k127_2910319_3 Formate/nitrite transporter K02598,K06212,K21993 - - 0.00000000000000000000000000000000000000000000000000000007336 198.0
HFD2_k127_2910319_4 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000003617 116.0
HFD2_k127_291088_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 543.0
HFD2_k127_291088_1 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 360.0
HFD2_k127_291088_2 Belongs to the UPF0271 (lamB) family K07160 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 330.0
HFD2_k127_291088_3 Allophanate hydrolase subunit 2 K06350 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001007 263.0
HFD2_k127_291088_4 Allophanate hydrolase subunit 1 K06351 - - 0.000000000000000000000000000000000000000000000000000004584 198.0
HFD2_k127_291088_5 Nitrile hydratase, alpha chain K01721,K20807 - 4.2.1.84 0.000000000000000000000000000000000000000000000007658 172.0
HFD2_k127_291088_6 - - - - 0.00000000000000002978 91.0
HFD2_k127_2911214_0 Belongs to the ABC transporter superfamily K02031,K02032,K13896 - - 2.841e-195 638.0
HFD2_k127_2911214_1 PFAM extracellular solute-binding protein, family 5 K02035,K13893 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 590.0
HFD2_k127_2911214_2 transport system permease component K02033,K13894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 500.0
HFD2_k127_2911214_3 PFAM binding-protein-dependent transport systems inner membrane component K13895 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008573 475.0
HFD2_k127_2911214_4 Voltage-dependent anion channel - - - 0.0000000000000117 75.0
HFD2_k127_2911966_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1386.0
HFD2_k127_2911966_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 5.842e-279 867.0
HFD2_k127_2911966_10 depolymerase K05973 - 3.1.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007616 331.0
HFD2_k127_2911966_11 Endonuclease Exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007136 306.0
HFD2_k127_2911966_12 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002929 272.0
HFD2_k127_2911966_13 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000551 271.0
HFD2_k127_2911966_14 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001185 263.0
HFD2_k127_2911966_15 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000003635 216.0
HFD2_k127_2911966_16 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000385 225.0
HFD2_k127_2911966_17 Bacterial regulatory proteins, tetR family K16137 - - 0.0000000000000000000000000000000000000000000000000000000009436 207.0
HFD2_k127_2911966_18 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000000000000000000000000000000001301 196.0
HFD2_k127_2911966_19 Belongs to the ComB family K05979 - 3.1.3.71 0.00000000000000000000000000000000000000000000000000000582 198.0
HFD2_k127_2911966_2 Acetyl-coenzyme A synthetase N-terminus K01907 - 6.2.1.16 1.114e-245 781.0
HFD2_k127_2911966_20 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000002028 190.0
HFD2_k127_2911966_21 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000001995 175.0
HFD2_k127_2911966_22 PFAM NUDIX hydrolase K08310 - 3.6.1.67 0.000000000000000000000000000000000000000000009007 177.0
HFD2_k127_2911966_23 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000000000000000000000000001224 166.0
HFD2_k127_2911966_24 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000001425 166.0
HFD2_k127_2911966_25 Phospholipase/Carboxylesterase K06999 - - 0.00000000000000000000000000000000000001376 153.0
HFD2_k127_2911966_26 Protein of unknown function (DUF2946) - - - 0.0000000000000000000000000000000000001179 147.0
HFD2_k127_2911966_27 Ribonuclease K01167 - 3.1.27.3 0.0000000000000000000000000000000001062 137.0
HFD2_k127_2911966_28 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000001323 129.0
HFD2_k127_2911966_29 PFAM cobalamin (vitamin B12) biosynthesis CbiX protein K03795 - 4.99.1.3 0.0000000000000000000000000000005833 127.0
HFD2_k127_2911966_3 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 1.042e-212 675.0
HFD2_k127_2911966_30 Putative regulatory protein - - - 0.00000000000000000000000007357 109.0
HFD2_k127_2911966_31 Oxidizes proline to glutamate for use as a carbon and nitrogen source K00249,K00294,K13821 - 1.2.1.88,1.3.8.7,1.5.5.2 0.000000000000002613 80.0
HFD2_k127_2911966_32 Barstar (barnase inhibitor) - - - 0.000000000000008337 84.0
HFD2_k127_2911966_4 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 1.698e-203 638.0
HFD2_k127_2911966_5 PFAM ABC transporter K02471 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 622.0
HFD2_k127_2911966_6 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005158 400.0
HFD2_k127_2911966_7 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004089 389.0
HFD2_k127_2911966_8 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009071 380.0
HFD2_k127_2911966_9 ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 342.0
HFD2_k127_2924630_0 Malic enzyme K00029 - 1.1.1.40 0.0 1055.0
HFD2_k127_2924630_1 PFAM aminotransferase, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008472 416.0
HFD2_k127_2924630_10 - - - - 0.000000000000000000005388 96.0
HFD2_k127_2924630_11 Protein of unknown function (DUF2442) - - - 0.00000006166 63.0
HFD2_k127_2924630_12 Histone H1-like nucleoprotein HC2 K11275 - - 0.00001486 51.0
HFD2_k127_2924630_2 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 424.0
HFD2_k127_2924630_3 reductase subunit beta K00526 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005047 308.0
HFD2_k127_2924630_4 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003511 291.0
HFD2_k127_2924630_5 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.000000000000000000000000000000000000000000000000000000000003706 215.0
HFD2_k127_2924630_6 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000002621 186.0
HFD2_k127_2924630_7 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000004684 163.0
HFD2_k127_2924630_8 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.000000000000000000000000000000003716 138.0
HFD2_k127_2924630_9 - - - - 0.0000000000000000000000071 106.0
HFD2_k127_2926906_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000439 470.0
HFD2_k127_2926906_1 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 301.0
HFD2_k127_2926906_2 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005869 284.0
HFD2_k127_2926906_3 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004271 275.0
HFD2_k127_2926906_4 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000001271 273.0
HFD2_k127_2926906_5 COG1512 Beta-propeller domains of methanol dehydrogenase type K06872 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002591 257.0
HFD2_k127_2926906_6 Pfam:TPM - - - 0.0000000000000000000000000000000000000000000009449 182.0
HFD2_k127_2926906_7 paraquat-inducible protein A K03808 - - 0.0000000000000000000000000000000000000002112 157.0
HFD2_k127_2926906_8 Paraquat-inducible protein B K06192 - - 0.00000000000000000000004515 103.0
HFD2_k127_2926906_9 PFAM thioesterase superfamily - - - 0.000000000000001892 86.0
HFD2_k127_2933531_0 Belongs to the glycosyl hydrolase 57 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002822 518.0
HFD2_k127_2933531_1 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 486.0
HFD2_k127_2986253_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1332.0
HFD2_k127_2986253_1 Dehydrogenase E1 component K00164 - 1.2.4.2 0.0 1321.0
HFD2_k127_2986253_10 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 555.0
HFD2_k127_2986253_11 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 563.0
HFD2_k127_2986253_12 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004701 550.0
HFD2_k127_2986253_13 FAD binding domain K00480 - 1.14.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 526.0
HFD2_k127_2986253_14 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006261 491.0
HFD2_k127_2986253_15 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 481.0
HFD2_k127_2986253_16 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002794 519.0
HFD2_k127_2986253_17 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K01841,K03417 - 4.1.3.30,5.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000692 455.0
HFD2_k127_2986253_18 binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 423.0
HFD2_k127_2986253_19 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006902 419.0
HFD2_k127_2986253_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1016.0
HFD2_k127_2986253_20 PFAM AFG1-family ATPase K06916 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 427.0
HFD2_k127_2986253_21 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00001 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007716 402.0
HFD2_k127_2986253_22 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 397.0
HFD2_k127_2986253_23 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008075 381.0
HFD2_k127_2986253_24 HMGL-like K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 354.0
HFD2_k127_2986253_25 NAD(P)H-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002727 321.0
HFD2_k127_2986253_26 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 308.0
HFD2_k127_2986253_27 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 300.0
HFD2_k127_2986253_28 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 297.0
HFD2_k127_2986253_29 PFAM conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004648 300.0
HFD2_k127_2986253_3 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 2.275e-293 914.0
HFD2_k127_2986253_30 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 289.0
HFD2_k127_2986253_31 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001319 278.0
HFD2_k127_2986253_32 SMART Tetratricopeptide domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001593 256.0
HFD2_k127_2986253_33 Belongs to the GbsR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003129 252.0
HFD2_k127_2986253_34 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000000000000002653 168.0
HFD2_k127_2986253_35 Histidine phosphatase superfamily (branch 1) - - - 0.000000000000000000000000000000000000000000003863 171.0
HFD2_k127_2986253_36 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.00000000000000000000000000000000000000000002087 174.0
HFD2_k127_2986253_37 Protein of unknown function, DUF393 - - - 0.0000000000000000000000000000000000000001524 163.0
HFD2_k127_2986253_38 Haem-degrading K11477 - - 0.0000000000000000000000000000000000004252 143.0
HFD2_k127_2986253_39 Domain of unknown function (DUF4212) - - - 0.00000000000000000000000000000003709 128.0
HFD2_k127_2986253_4 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 2.971e-258 803.0
HFD2_k127_2986253_40 Haem-degrading - - - 0.0000000000000000000000000000001526 135.0
HFD2_k127_2986253_41 Exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000006456 132.0
HFD2_k127_2986253_42 membrane K15977 - - 0.00000000000000000000000000005203 122.0
HFD2_k127_2986253_43 Succinate dehydrogenase, hydrophobic K00242 - - 0.0000000000000000000000000003754 123.0
HFD2_k127_2986253_44 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.00000000000000000000000000057 119.0
HFD2_k127_2986253_45 Tetratricopeptide repeat - - - 0.00000000000000000000000003621 119.0
HFD2_k127_2986253_46 COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) K04762 - - 0.000000000000001959 78.0
HFD2_k127_2986253_47 - - - - 0.000000000000003727 79.0
HFD2_k127_2986253_48 - - - - 0.0000000000001247 76.0
HFD2_k127_2986253_5 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 7.551e-257 814.0
HFD2_k127_2986253_50 Flavinator of succinate dehydrogenase K09159 - - 0.00000000005071 73.0
HFD2_k127_2986253_52 - - - - 0.0000001466 53.0
HFD2_k127_2986253_53 Protein of unknown function (DUF3460) - - - 0.0000001764 57.0
HFD2_k127_2986253_6 2-methylcitrate dehydratase K01720 - 4.2.1.79 1.061e-250 786.0
HFD2_k127_2986253_7 Belongs to the citrate synthase family K01647 - 2.3.3.1 2.961e-229 715.0
HFD2_k127_2986253_8 Protein involved in oxidation-reduction process K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 2.209e-201 638.0
HFD2_k127_2986253_9 Belongs to the citrate synthase family K01659 - 2.3.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 599.0
HFD2_k127_2991410_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 6.986e-204 649.0
HFD2_k127_2991410_1 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 1.327e-199 649.0
HFD2_k127_2991410_10 BadF/BadG/BcrA/BcrD ATPase family K04115 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000006675 208.0
HFD2_k127_2991410_11 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.000000000000000000000000000000000000000000004214 165.0
HFD2_k127_2991410_12 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000000005856 167.0
HFD2_k127_2991410_13 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.000000000000000000000000000000000000000000006695 173.0
HFD2_k127_2991410_14 Rubrerythrin - - - 0.000000000000000000000000000000005987 135.0
HFD2_k127_2991410_2 Enoyl-CoA hydratase/isomerase K07539 - 3.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 583.0
HFD2_k127_2991410_3 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 558.0
HFD2_k127_2991410_4 Benzoyl-CoA reductase subunit K04114 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008988 573.0
HFD2_k127_2991410_5 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009042 432.0
HFD2_k127_2991410_6 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 402.0
HFD2_k127_2991410_7 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 307.0
HFD2_k127_2991410_8 Enoyl-(Acyl carrier protein) reductase K00059,K07535 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 292.0
HFD2_k127_2991410_9 Vitamin k epoxide reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001346 265.0
HFD2_k127_3110725_0 twitching motility protein K02670 - - 2.822e-200 628.0
HFD2_k127_3110725_1 Belongs to the methyltransferase superfamily K07444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 444.0
HFD2_k127_3110725_10 PFAM type II secretion system protein E K02669 - - 0.0000000000000000000000000000005975 122.0
HFD2_k127_3110725_11 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14392 - - 0.00000000000000000000007326 100.0
HFD2_k127_3110725_2 PFAM ABC transporter related K01990,K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005666 428.0
HFD2_k127_3110725_3 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000965 372.0
HFD2_k127_3110725_4 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 348.0
HFD2_k127_3110725_5 Transport permease protein K09694 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001997 276.0
HFD2_k127_3110725_6 VanZ like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000005351 244.0
HFD2_k127_3110725_7 Serine aminopeptidase, S33 K07018 - - 0.0000000000000000000000000000000000000000000000000000000000000001829 232.0
HFD2_k127_3110725_8 lipid kinase activity - - - 0.000000000000000000000000000000000000000000000000000009945 210.0
HFD2_k127_3110725_9 Ferredoxin - - - 0.00000000000000000000000000000000000000000099 173.0
HFD2_k127_3135890_0 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007983 342.0
HFD2_k127_3135890_1 Large terminal subunit K16319 - 1.14.12.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001056 284.0
HFD2_k127_3135890_10 Receptor family ligand binding region K01999 - - 0.00000000000000000000000004912 120.0
HFD2_k127_3135890_11 Tripartite tricarboxylate transporter family receptor - - - 0.0001221 50.0
HFD2_k127_3135890_2 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004163 256.0
HFD2_k127_3135890_3 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000347 236.0
HFD2_k127_3135890_4 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000002223 217.0
HFD2_k127_3135890_5 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000002712 213.0
HFD2_k127_3135890_6 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000008253 186.0
HFD2_k127_3135890_7 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000333 156.0
HFD2_k127_3135890_8 dioxygenase K16320,K18243 - 1.14.12.1,1.14.13.172 0.0000000000000000000000000000000001399 143.0
HFD2_k127_3135890_9 - - - - 0.0000000000000000000000000002296 118.0
HFD2_k127_3139713_0 ABC transporter transmembrane region K06147 - - 5.184e-234 739.0
HFD2_k127_3139713_1 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 3.594e-213 672.0
HFD2_k127_3139713_10 SMP-30/Gluconolaconase/LRE-like region K13874,K14274 - 3.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000003643 261.0
HFD2_k127_3139713_11 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000003862 256.0
HFD2_k127_3139713_12 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000005537 229.0
HFD2_k127_3139713_13 - - - - 0.0001465 48.0
HFD2_k127_3139713_2 AcyL-CoA dehydrogenase K06445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000553 559.0
HFD2_k127_3139713_3 Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 518.0
HFD2_k127_3139713_4 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 K15461 - 2.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 511.0
HFD2_k127_3139713_5 PDZ DHR GLGF domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 360.0
HFD2_k127_3139713_6 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 338.0
HFD2_k127_3139713_7 Histidine-specific methyltransferase, SAM-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 326.0
HFD2_k127_3139713_8 Beta-lactamase enzyme family K07262 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 292.0
HFD2_k127_3139713_9 carboxylic acid catabolic process K01856 - 5.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001201 263.0
HFD2_k127_315497_0 carbohydrate phosphatase activity K01086 - 3.1.3.11,3.1.3.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004394 473.0
HFD2_k127_315497_1 Phosphoribulokinase / Uridine kinase family K00855 - 2.7.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 375.0
HFD2_k127_315497_2 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - 0.0000000000000000000000000000000000000000000000005392 187.0
HFD2_k127_315497_3 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000003955 124.0
HFD2_k127_3172607_0 Bifunctional transglycosylase second domain K05365 - 2.4.1.129,3.4.16.4 1.363e-266 838.0
HFD2_k127_3172607_1 Belongs to the UbiD family K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 603.0
HFD2_k127_3172607_2 Benzoate membrane transport protein K05782 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 454.0
HFD2_k127_3172607_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 432.0
HFD2_k127_3172607_4 TRAP transporter, 4TM 12TM fusion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005563 409.0
HFD2_k127_3172607_5 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007234 371.0
HFD2_k127_3172607_6 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000002133 186.0
HFD2_k127_3172607_7 MaoC like domain - - - 0.000000000000000000000000000000000000000007842 175.0
HFD2_k127_3172607_8 TRAP transporter solute receptor TAXI family protein - - - 0.000000000000000000000009932 114.0
HFD2_k127_3172607_9 - - - - 0.0000000000000000000009495 108.0
HFD2_k127_3194951_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 3.842e-204 642.0
HFD2_k127_3194951_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 614.0
HFD2_k127_3194951_10 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000002031 248.0
HFD2_k127_3194951_11 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.0000000000000000000000000000000000000000000000000000000000000213 218.0
HFD2_k127_3194951_12 Bacterial regulatory proteins, tetR family K05501 - - 0.00000000000000000000000000000000000000000000000000000000002259 211.0
HFD2_k127_3194951_13 Phosphoribosyl transferase domain - - - 0.0000000000000000000000000000000000000000000000000000001086 205.0
HFD2_k127_3194951_14 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.00000000000000000000000000000000000000000000000596 181.0
HFD2_k127_3194951_15 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000001572 169.0
HFD2_k127_3194951_16 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000001475 154.0
HFD2_k127_3194951_17 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000247 147.0
HFD2_k127_3194951_18 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.0000000000000000000000000000146 119.0
HFD2_k127_3194951_19 Integral membrane protein (DUF2244) - - - 0.00000000000000000000844 98.0
HFD2_k127_3194951_2 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 460.0
HFD2_k127_3194951_20 Cysteine-rich CWC - - - 0.0001682 46.0
HFD2_k127_3194951_3 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009679 446.0
HFD2_k127_3194951_4 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 448.0
HFD2_k127_3194951_5 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 383.0
HFD2_k127_3194951_6 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 356.0
HFD2_k127_3194951_7 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004906 329.0
HFD2_k127_3194951_8 Pyrimidine 5''-nucleotidase K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000001063 236.0
HFD2_k127_3194951_9 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000003198 239.0
HFD2_k127_3220802_0 Phospholipase D Active site motif K01115 - 3.1.4.4 1.317e-252 797.0
HFD2_k127_3220802_1 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 494.0
HFD2_k127_3220802_10 - - - - 0.000000000000000000001563 99.0
HFD2_k127_3220802_2 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 384.0
HFD2_k127_3220802_3 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 299.0
HFD2_k127_3220802_4 Catechol dioxygenase N terminus K03381 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006725,GO:0008150,GO:0008152,GO:0008199,GO:0009056,GO:0009712,GO:0009987,GO:0016491,GO:0016701,GO:0016702,GO:0018576,GO:0018958,GO:0019114,GO:0019336,GO:0019439,GO:0019614,GO:0019615,GO:0042952,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 1.13.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000001059 255.0
HFD2_k127_3220802_5 Protein of unknown function (DUF3300) - - - 0.00000000000000000000000000000000000000000000002067 184.0
HFD2_k127_3220802_6 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000008983 169.0
HFD2_k127_3220802_7 protein histidine kinase activity - - - 0.000000000000000000000000000000005571 138.0
HFD2_k127_3220802_9 - - - - 0.000000000000000000000003633 110.0
HFD2_k127_3236336_0 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000719 475.0
HFD2_k127_3236336_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006179 421.0
HFD2_k127_3236336_10 DoxX K15977 - - 0.000000000006261 73.0
HFD2_k127_3236336_11 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000006197 57.0
HFD2_k127_3236336_2 PFAM ABC transporter related K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004818 369.0
HFD2_k127_3236336_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 326.0
HFD2_k127_3236336_4 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 307.0
HFD2_k127_3236336_5 PFAM ABC transporter related K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 297.0
HFD2_k127_3236336_6 Methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002416 304.0
HFD2_k127_3236336_7 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000001656 238.0
HFD2_k127_3236336_8 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain K02479 - - 0.0000000000000000000000000000000000000000000000000008071 190.0
HFD2_k127_3236336_9 Luciferase-like monooxygenase K15854 - 1.14.14.3 0.000000000000000000000000000000000000000538 154.0
HFD2_k127_3244509_0 PFAM Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 563.0
HFD2_k127_3244509_1 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006691 357.0
HFD2_k127_3244509_2 Leucyl/phenylalanyl-tRNA protein transferase K00684 - 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002426 273.0
HFD2_k127_3244509_3 AMP-binding enzyme K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000107 268.0
HFD2_k127_3244509_4 Nudix N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002787 259.0
HFD2_k127_3244509_5 plastoquinol--plastocyanin reductase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004632 254.0
HFD2_k127_3244509_6 Haloacid dehalogenase-like hydrolase K01560 - 3.8.1.2 0.0000000000000000000000000000000000000000000000000000000001787 215.0
HFD2_k127_3244509_7 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.00000000000001143 85.0
HFD2_k127_3264405_0 Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002455 643.0
HFD2_k127_3264405_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 553.0
HFD2_k127_3264405_10 peptidase S16 K07157 - - 0.00000000000000000000000000000000000000000000000000023 202.0
HFD2_k127_3264405_11 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000000000003712 183.0
HFD2_k127_3264405_12 Prokaryotic N-terminal methylation motif - - - 0.00000000000000000000000000000000000000000000000005006 186.0
HFD2_k127_3264405_14 Prokaryotic N-terminal methylation motif - - - 0.00000000000000000000000000000000000000001241 169.0
HFD2_k127_3264405_15 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.00000000000000000000000000000000006928 149.0
HFD2_k127_3264405_16 seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing K05808 - - 0.000000000000000000000000000002403 134.0
HFD2_k127_3264405_17 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.000000000000000000000000007513 128.0
HFD2_k127_3264405_18 - - - - 0.00000000000000000003026 106.0
HFD2_k127_3264405_19 - - - - 0.0000000000000000005327 95.0
HFD2_k127_3264405_2 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008611 421.0
HFD2_k127_3264405_20 Conserved hypothetical protein 698 - - - 0.0000000000000939 79.0
HFD2_k127_3264405_21 - - - - 0.00000000009646 74.0
HFD2_k127_3264405_3 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 412.0
HFD2_k127_3264405_4 Lipopolysaccharide export system ATP-binding protein K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 372.0
HFD2_k127_3264405_5 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004889 324.0
HFD2_k127_3264405_6 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 316.0
HFD2_k127_3264405_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000007389 237.0
HFD2_k127_3264405_9 COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) K02806 - - 0.0000000000000000000000000000000000000000000000000000000000001033 216.0
HFD2_k127_327952_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.084e-225 711.0
HFD2_k127_327952_1 Polyphosphate kinase 2 (PPK2) - - - 3.256e-211 668.0
HFD2_k127_327952_10 - - - - 0.0000137 58.0
HFD2_k127_327952_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006022 400.0
HFD2_k127_327952_3 Cytochrome c bacterial - - - 0.00000000000000000000000000000000000000000000000000000000000000000003133 243.0
HFD2_k127_327952_4 Universal stress protein UspA - - - 0.00000000000000000000000000000000000000000000000000000000000000002572 238.0
HFD2_k127_327952_5 OsmC-like protein - - - 0.00000000000000000000000000000000000001146 149.0
HFD2_k127_327952_6 Aminoacyl-tRNA editing domain K19055 - - 0.000000000000000000000000000000000000321 161.0
HFD2_k127_327952_7 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000009551 126.0
HFD2_k127_327952_8 - - - - 0.0000000000000000001377 104.0
HFD2_k127_327952_9 universal stress protein - - - 0.000000000000000002803 91.0
HFD2_k127_3287929_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007531 569.0
HFD2_k127_3287929_1 Amidohydrolase K01686 - 4.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 492.0
HFD2_k127_3287929_2 Divalent cation transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 422.0
HFD2_k127_3287929_3 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003483 414.0
HFD2_k127_3287929_4 Phospholipase A1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000282 287.0
HFD2_k127_3287929_5 CBS domain - - - 0.000000000000000000000000000000000000000000002318 169.0
HFD2_k127_3287929_6 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000000000000000000002777 141.0
HFD2_k127_3287929_7 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000002612 135.0
HFD2_k127_3287929_8 LysR family transcription regulator protein - - - 0.00000000000000000000009695 100.0
HFD2_k127_3308498_0 Bacterial extracellular solute-binding protein K02027 - - 1.922e-208 656.0
HFD2_k127_3308498_1 ABC-type sugar K02025,K10237 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 501.0
HFD2_k127_3308498_10 BFD-like [2Fe-2S] binding domain K02192 - - 0.000000000002031 69.0
HFD2_k127_3308498_11 Hemin uptake protein hemP - - - 0.000001828 51.0
HFD2_k127_3308498_2 ABC-type sugar transport system, permease component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 491.0
HFD2_k127_3308498_3 ATPase component of ABC-type sugar transporter K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009844 474.0
HFD2_k127_3308498_4 Belongs to the IlvD Edd family K01687,K22186 - 4.2.1.82,4.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 345.0
HFD2_k127_3308498_5 D-isomer specific 2-hydroxyacid dehydrogenase catalytic region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009616 319.0
HFD2_k127_3308498_6 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 307.0
HFD2_k127_3308498_7 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000001065 236.0
HFD2_k127_3308498_8 high-affinity ferrous iron transmembrane transporter activity K07243 - - 0.000000000000000000000000000000000000000000000000000000002385 208.0
HFD2_k127_3308498_9 phosphate-selective porin O and P - - - 0.00000000000003306 78.0
HFD2_k127_3392021_0 AMP-binding enzyme K12508 - 6.2.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005155 410.0
HFD2_k127_3392021_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 344.0
HFD2_k127_3396216_0 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 458.0
HFD2_k127_3396216_1 Predicted membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 374.0
HFD2_k127_3396216_2 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001073 257.0
HFD2_k127_3396216_3 Protein chain release factor B K15034 - - 0.0000000000000000000000000000000000000000001742 162.0
HFD2_k127_3396216_4 peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000001248 180.0
HFD2_k127_3396216_5 LemA family K03744 - - 0.0000000000000000000000000004128 120.0
HFD2_k127_3396216_6 diguanylate cyclase - - - 0.0000000000000000000000004841 109.0
HFD2_k127_3396216_7 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0004605 44.0
HFD2_k127_3496054_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1125.0
HFD2_k127_3496054_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 7.952e-297 946.0
HFD2_k127_3496054_10 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004671 365.0
HFD2_k127_3496054_11 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 362.0
HFD2_k127_3496054_12 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 351.0
HFD2_k127_3496054_13 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 341.0
HFD2_k127_3496054_14 Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002159 274.0
HFD2_k127_3496054_15 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009054 269.0
HFD2_k127_3496054_16 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000001149 263.0
HFD2_k127_3496054_17 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000006159 240.0
HFD2_k127_3496054_18 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.000000000000000000000000000000000000000000000000000000000003014 221.0
HFD2_k127_3496054_19 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000000000005704 198.0
HFD2_k127_3496054_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 1.175e-277 896.0
HFD2_k127_3496054_20 Belongs to the skp family K06142 - - 0.00000000000000000000000000000000000000000000000000006236 191.0
HFD2_k127_3496054_21 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000005532 179.0
HFD2_k127_3496054_22 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.00000000000000000000000000000000000000001192 172.0
HFD2_k127_3496054_23 Psort location Cytoplasmic, score 8.96 - - - 0.000000000000000000000000000000000000000309 153.0
HFD2_k127_3496054_24 Belongs to the UPF0125 (RnfH) family K09801 - - 0.00000000000002697 79.0
HFD2_k127_3496054_3 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006157 492.0
HFD2_k127_3496054_4 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 456.0
HFD2_k127_3496054_5 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 454.0
HFD2_k127_3496054_6 Methionine aminopeptidase K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 439.0
HFD2_k127_3496054_7 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 385.0
HFD2_k127_3496054_8 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 382.0
HFD2_k127_3496054_9 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 376.0
HFD2_k127_3524739_0 Bacterial DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1364.0
HFD2_k127_3524739_1 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 470.0
HFD2_k127_3524739_2 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009742 400.0
HFD2_k127_3524739_3 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 354.0
HFD2_k127_3524739_4 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007797 269.0
HFD2_k127_3524739_5 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002754 265.0
HFD2_k127_3524739_6 Type IV pilus biogenesis stability protein PilW - - - 0.000000000000000000000000000000000009173 147.0
HFD2_k127_3524739_7 Acylphosphatase K01512 - 3.6.1.7 0.000000000000000000001226 97.0
HFD2_k127_3524739_8 FAD binding domain K09828 - 1.3.1.72 0.00000000000003519 87.0
HFD2_k127_3524739_9 Belongs to the DnaA family K10763 - - 0.000000000004216 68.0
HFD2_k127_3551835_0 asparaginyl-tRNA synthetase K01893 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.22 3.512e-213 673.0
HFD2_k127_3551835_1 Putative modulator of DNA gyrase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 541.0
HFD2_k127_3551835_10 Staphylococcal nuclease homologues - - - 0.0000000000000000000000000000006932 129.0
HFD2_k127_3551835_11 Cell Wall Hydrolase - - - 0.0000000000000000000000002217 111.0
HFD2_k127_3551835_13 Spore Coat Protein U domain - - - 0.00000157 56.0
HFD2_k127_3551835_14 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.000007411 49.0
HFD2_k127_3551835_2 Uncharacterised MFS-type transporter YbfB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 507.0
HFD2_k127_3551835_3 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000623 501.0
HFD2_k127_3551835_4 ABC transporter K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 462.0
HFD2_k127_3551835_5 Putative modulator of DNA gyrase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 422.0
HFD2_k127_3551835_6 transport, permease protein K01992 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002741 413.0
HFD2_k127_3551835_7 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 372.0
HFD2_k127_3551835_8 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000246 186.0
HFD2_k127_3551835_9 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000001928 162.0
HFD2_k127_3566842_0 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003632 499.0
HFD2_k127_3566842_1 AMP-binding enzyme K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000001982 254.0
HFD2_k127_3566842_2 Amino acid amide ABC transporter substrate-binding protein, HAAT family K01999 - - 0.00000000000000000000000000000000001903 135.0
HFD2_k127_3580571_0 peptidase, M20 - - - 2.891e-203 642.0
HFD2_k127_3580571_1 PFAM D-galactarate dehydratase Altronate hydrolase domain protein K01685,K01708,K16846 - 4.2.1.42,4.2.1.7,4.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 473.0
HFD2_k127_3580571_2 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007948 468.0
HFD2_k127_3580571_3 RNA methyltransferase K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000002055 222.0
HFD2_k127_3580571_4 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000000000001914 191.0
HFD2_k127_3580571_5 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.000000000000000000000000000000000000008291 162.0
HFD2_k127_3580571_6 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000001286 86.0
HFD2_k127_3626339_0 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 543.0
HFD2_k127_3626339_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 324.0
HFD2_k127_3626339_2 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000001025 228.0
HFD2_k127_3626339_3 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000004227 84.0
HFD2_k127_3649325_0 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001014 304.0
HFD2_k127_3649325_1 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001806 275.0
HFD2_k127_3649325_2 PFAM Metal-dependent phosphohydrolase, HD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002444 276.0
HFD2_k127_3649325_3 Domain of unknown function (DUF4142) K08995 - - 0.0000000000000000002698 94.0
HFD2_k127_3649325_4 - - - - 0.00000000000000000236 89.0
HFD2_k127_3685398_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 8.888e-237 740.0
HFD2_k127_3685398_1 Soluble lytic murein transglycosylase L domain K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002769 572.0
HFD2_k127_3685398_10 Protein of unknown function (DUF2877) - - - 0.00000000000000000000006391 113.0
HFD2_k127_3685398_11 Protein of unknown function (DUF2905) - - - 0.00000002141 57.0
HFD2_k127_3685398_2 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 376.0
HFD2_k127_3685398_3 epimerase dehydratase K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001271 304.0
HFD2_k127_3685398_4 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000007684 252.0
HFD2_k127_3685398_5 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000001791 228.0
HFD2_k127_3685398_6 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - 0.000000000000000000000000000000000000000000000000000000000002292 215.0
HFD2_k127_3685398_7 Urate oxidase N-terminal - - - 0.00000000000000000000000000000000000000000000000004617 186.0
HFD2_k127_3685398_8 membrane - - - 0.00000000000000000000000000000005581 130.0
HFD2_k127_3685398_9 FAD binding domain K00481 - 1.14.13.2 0.000000000000000000000000000289 118.0
HFD2_k127_3763982_0 Indolepyruvate ferredoxin oxidoreductase K00179 - 1.2.7.8 7.156e-303 942.0
HFD2_k127_3763982_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 5.226e-232 723.0
HFD2_k127_3763982_10 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 350.0
HFD2_k127_3763982_11 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 333.0
HFD2_k127_3763982_12 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 321.0
HFD2_k127_3763982_13 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 298.0
HFD2_k127_3763982_14 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 291.0
HFD2_k127_3763982_15 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006647 283.0
HFD2_k127_3763982_16 Forms part of the polypeptide exit tunnel K02926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001745 281.0
HFD2_k127_3763982_17 esterase K01432 - 3.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000735 281.0
HFD2_k127_3763982_18 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000491 258.0
HFD2_k127_3763982_19 Ribosomal protein L16p/L10e K02878 - - 0.00000000000000000000000000000000000000000000000000000000000000000002905 233.0
HFD2_k127_3763982_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding K00179 - 1.2.7.8 7.082e-208 658.0
HFD2_k127_3763982_20 Cysteine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000941 251.0
HFD2_k127_3763982_21 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000000000000000000000000000000000007951 251.0
HFD2_k127_3763982_22 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000009717 223.0
HFD2_k127_3763982_23 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000000000000008849 219.0
HFD2_k127_3763982_24 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000000000000000000000002286 225.0
HFD2_k127_3763982_25 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000001486 211.0
HFD2_k127_3763982_26 Ribosomal protein L17 K02879 - - 0.0000000000000000000000000000000000000000000000000000000004468 204.0
HFD2_k127_3763982_27 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000004824 195.0
HFD2_k127_3763982_28 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000002848 188.0
HFD2_k127_3763982_29 Binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000000007512 192.0
HFD2_k127_3763982_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009907 551.0
HFD2_k127_3763982_30 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000004496 183.0
HFD2_k127_3763982_31 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000000000000000000000000008591 175.0
HFD2_k127_3763982_32 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000005893 160.0
HFD2_k127_3763982_33 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.00000000000000000000000000000000000003051 145.0
HFD2_k127_3763982_34 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000006088 142.0
HFD2_k127_3763982_35 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.000000000000000000000000000000004766 140.0
HFD2_k127_3763982_36 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000006894 136.0
HFD2_k127_3763982_37 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000001425 114.0
HFD2_k127_3763982_38 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000003199 87.0
HFD2_k127_3763982_39 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000000000121 88.0
HFD2_k127_3763982_4 Histidine Phosphotransfer domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 537.0
HFD2_k127_3763982_40 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000000002292 72.0
HFD2_k127_3763982_41 Ribosomal protein L30 K02907 - - 0.000000000003467 79.0
HFD2_k127_3763982_42 Histidine Phosphotransfer domain - - - 0.0008164 48.0
HFD2_k127_3763982_5 Domain of unknown function (DUF4147) K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004649 501.0
HFD2_k127_3763982_6 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003706 443.0
HFD2_k127_3763982_7 Gentisate 1,2-dioxygenase K00450 - 1.13.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 441.0
HFD2_k127_3763982_8 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004653 449.0
HFD2_k127_3763982_9 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008286 360.0
HFD2_k127_3769452_0 dna topoisomerase III K03169 - 5.99.1.2 0.0 1108.0
HFD2_k127_3769452_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1072.0
HFD2_k127_3769452_10 DNA recombination-mediator protein A K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008075 381.0
HFD2_k127_3769452_11 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 374.0
HFD2_k127_3769452_12 Cobyrinic acid ac-diamide synthase K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 367.0
HFD2_k127_3769452_13 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 331.0
HFD2_k127_3769452_14 PFAM Peptidoglycan-binding LysM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 318.0
HFD2_k127_3769452_15 Formyl transferase, C-terminal domain K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006295 314.0
HFD2_k127_3769452_16 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000003581 232.0
HFD2_k127_3769452_17 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000000000000000000000007218 209.0
HFD2_k127_3769452_18 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109 - - 0.00000000000000000000000000000000000000000000000008187 181.0
HFD2_k127_3769452_19 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000423 189.0
HFD2_k127_3769452_2 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 1.899e-293 911.0
HFD2_k127_3769452_20 Domain of unknown function (DUF4390) - - - 0.0000000000000000000000000000000000000000000001265 175.0
HFD2_k127_3769452_21 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000000000001909 174.0
HFD2_k127_3769452_22 Belongs to the Smg family K03747 - - 0.0000000000000000000000000000000001958 137.0
HFD2_k127_3769452_23 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000000000000000000001349 141.0
HFD2_k127_3769452_24 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0000000000000000000000000009355 112.0
HFD2_k127_3769452_25 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000001686 110.0
HFD2_k127_3769452_26 ATP synthase I chain K02116 - - 0.00000000000006944 83.0
HFD2_k127_3769452_27 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000008664 69.0
HFD2_k127_3769452_28 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000147 63.0
HFD2_k127_3769452_29 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - 0.0000002279 62.0
HFD2_k127_3769452_3 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 4.99e-290 900.0
HFD2_k127_3769452_30 PFAM Sugar isomerase (SIS) K02082 - - 0.000007628 50.0
HFD2_k127_3769452_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.716e-263 815.0
HFD2_k127_3769452_5 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 580.0
HFD2_k127_3769452_6 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 566.0
HFD2_k127_3769452_7 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 483.0
HFD2_k127_3769452_8 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006322 458.0
HFD2_k127_3769452_9 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 418.0
HFD2_k127_37862_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 6.981e-236 733.0
HFD2_k127_37862_1 - - - - 0.000000000000000000000000000000000000000000000003181 183.0
HFD2_k127_37862_2 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.00000000000000003675 85.0
HFD2_k127_3816234_0 Respiratory nitrate reductase alpha N-terminal K00370 - 1.7.5.1 0.0 2004.0
HFD2_k127_3816234_1 Respiratory nitrate reductase beta C-terminal K00371,K17051 - 1.7.5.1 2.556e-289 900.0
HFD2_k127_3816234_10 - - - - 0.0000000000000000000000000000000000000000234 158.0
HFD2_k127_3816234_2 nitrite reductase K00368 - 1.7.2.1 2.414e-214 680.0
HFD2_k127_3816234_3 PFAM NnrS family protein K07234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 364.0
HFD2_k127_3816234_4 Nitrate reductase K00374 - 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002766 283.0
HFD2_k127_3816234_5 protein involved in response to NO - - - 0.00000000000000000000000000000000000000000000000000000000000003107 226.0
HFD2_k127_3816234_6 Nitrate reductase, delta subunit K00373 - - 0.000000000000000000000000000000000000000000000004188 179.0
HFD2_k127_3816234_7 CRP FNR family K21563 - - 0.0000000000000000000000000000000000000000000005018 175.0
HFD2_k127_3816234_8 - - - - 0.00000000000000000000000000000000000000000007828 179.0
HFD2_k127_3816234_9 nitrite transporter K02575 - - 0.000000000000000000000000000000000000000001304 157.0
HFD2_k127_3817608_0 Single-stranded-DNA-specific exonuclease K07462 - - 1.543e-206 673.0
HFD2_k127_3817608_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009064 536.0
HFD2_k127_3817608_2 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007812 521.0
HFD2_k127_3817608_3 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000003643 198.0
HFD2_k127_3817608_4 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000001743 183.0
HFD2_k127_3817608_5 Cyclophilin-like K09143 - - 0.000000000000000000000000000000005563 143.0
HFD2_k127_3817608_6 KTSC domain - - - 0.000000004097 66.0
HFD2_k127_3874383_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 5.598e-282 888.0
HFD2_k127_3874383_1 helix_turn_helix gluconate operon transcriptional repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 494.0
HFD2_k127_388106_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 9.461e-216 692.0
HFD2_k127_388106_1 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 612.0
HFD2_k127_388106_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 394.0
HFD2_k127_388106_3 [2Fe-2S] binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000002957 248.0
HFD2_k127_388106_4 OmpA-like transmembrane domain - - - 0.00000000000000000000000000000000005491 143.0
HFD2_k127_388106_5 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.000000000000000000000000000009207 136.0
HFD2_k127_388106_6 OmpA-like transmembrane domain - - - 0.0000000000000000000002621 105.0
HFD2_k127_388106_7 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000001051 103.0
HFD2_k127_388106_8 OmpA-like transmembrane domain K03286 - - 0.000000000000000000004267 103.0
HFD2_k127_3895133_0 Radical SAM K01012 - 2.8.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003216 475.0
HFD2_k127_3895133_1 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000000000000000000000000000001286 218.0
HFD2_k127_3895133_2 GMP synthase (glutamine-hydrolyzing) activity - - - 0.00000000000000000000000000000000000000000000000000000000002829 219.0
HFD2_k127_3895133_3 4Fe-4S dicluster domain K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000006411 85.0
HFD2_k127_3923427_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 9.448e-290 901.0
HFD2_k127_3923427_1 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003844 428.0
HFD2_k127_3923427_2 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001077 289.0
HFD2_k127_3926616_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531,K12955 - 3.6.3.2 6.028e-241 771.0
HFD2_k127_3926616_1 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 3.234e-203 658.0
HFD2_k127_3926616_10 B12 binding domain K01849 - 5.4.99.2 0.0000000000000000000000000000000000003986 145.0
HFD2_k127_3926616_11 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000001009 141.0
HFD2_k127_3926616_12 adenylylsulfate kinase activity K00860,K00955 - 2.7.1.25,2.7.7.4 0.0000000000000000000000000000007126 140.0
HFD2_k127_3926616_13 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.000000000000000000000000002969 114.0
HFD2_k127_3926616_14 PFAM zinc finger, DksA TraR C4-type - - - 0.000000000000000000000000003389 115.0
HFD2_k127_3926616_15 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000004017 85.0
HFD2_k127_3926616_16 PFAM Nitroreductase family - - - 0.0000000000000007306 80.0
HFD2_k127_3926616_17 - - - - 0.000000000000001567 79.0
HFD2_k127_3926616_18 Pfam Response regulator receiver - - - 0.000000000007295 71.0
HFD2_k127_3926616_2 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000791 544.0
HFD2_k127_3926616_3 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 494.0
HFD2_k127_3926616_4 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 480.0
HFD2_k127_3926616_5 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 372.0
HFD2_k127_3926616_6 Belongs to the Glu Leu Phe Val dehydrogenases family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001509 263.0
HFD2_k127_3926616_7 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000000000000000000000000000000000004877 169.0
HFD2_k127_3926616_8 amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000008776 173.0
HFD2_k127_3926616_9 ribosomal large subunit export from nucleus - - - 0.0000000000000000000000000000000000000000001263 169.0
HFD2_k127_3936268_0 type II secretion system protein K02653 - - 1.171e-194 615.0
HFD2_k127_3936268_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 425.0
HFD2_k127_3936268_2 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008358 425.0
HFD2_k127_3936268_3 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 349.0
HFD2_k127_3936268_4 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 338.0
HFD2_k127_3936268_5 PFAM Cytochrome c assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000004412 243.0
HFD2_k127_3936268_6 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000000000003289 241.0
HFD2_k127_3936268_7 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000001094 85.0
HFD2_k127_3968511_0 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 5.164e-275 883.0
HFD2_k127_3968511_1 FAD dependent oxidoreductase K07077 - - 9.494e-259 833.0
HFD2_k127_3968511_10 Alpha/beta hydrolase of unknown function (DUF900) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 353.0
HFD2_k127_3968511_11 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007343 353.0
HFD2_k127_3968511_12 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003216 321.0
HFD2_k127_3968511_13 peptidase S1 and S6, chymotrypsin Hap - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 295.0
HFD2_k127_3968511_14 peptidase S1 and S6, chymotrypsin Hap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001899 289.0
HFD2_k127_3968511_15 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001286 265.0
HFD2_k127_3968511_16 PFAM MaoC domain protein dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000005105 228.0
HFD2_k127_3968511_17 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000001097 215.0
HFD2_k127_3968511_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000002372 175.0
HFD2_k127_3968511_19 CBS domain - - - 0.0000000000000000000000000000000000000972 150.0
HFD2_k127_3968511_2 Aldehyde dehydrogenase family K00128 - 1.2.1.3 1.955e-202 668.0
HFD2_k127_3968511_20 Response regulator receiver K02485 - - 0.0000000000000000000000000001249 125.0
HFD2_k127_3968511_21 PFAM thioesterase superfamily protein K01075 - 3.1.2.23 0.000000000000000000000000004932 122.0
HFD2_k127_3968511_22 Protein of unknown function (DUF2721) - - - 0.00000000000000000000000005935 114.0
HFD2_k127_3968511_23 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000001551 65.0
HFD2_k127_3968511_24 Protein of unknown function (DUF2799) - - - 0.0000001901 57.0
HFD2_k127_3968511_26 Belongs to the N-Me-Phe pilin family K02650,K02682 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.0002177 44.0
HFD2_k127_3968511_3 ACT domain K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 606.0
HFD2_k127_3968511_4 Membrane-associated sensor, integral membrane domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007019 533.0
HFD2_k127_3968511_5 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 514.0
HFD2_k127_3968511_6 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007578 515.0
HFD2_k127_3968511_7 Von Willebrand factor type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 419.0
HFD2_k127_3968511_8 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 413.0
HFD2_k127_3968511_9 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 415.0
HFD2_k127_3968558_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 477.0
HFD2_k127_3968558_1 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006769 286.0
HFD2_k127_3968558_2 abc transporter K02003,K05685 - - 0.00000000000000000000000000000000000000002599 155.0
HFD2_k127_3968558_3 Belongs to the N-Me-Phe pilin family K02650,K02682 GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - 0.0002177 44.0
HFD2_k127_3973048_0 transport system, large permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009407 565.0
HFD2_k127_3973048_1 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 433.0
HFD2_k127_3973048_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 331.0
HFD2_k127_3973048_3 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008328 333.0
HFD2_k127_3973048_4 hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001212 257.0
HFD2_k127_3973048_5 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000001316 191.0
HFD2_k127_3973048_6 TRAP-type C4-dicarboxylate transport system small permease component - - - 0.000000000000000000000000000000000000000000000004068 177.0
HFD2_k127_3973048_7 Adenosine specific kinase K09129 - - 0.000000000000000000000000000000002974 136.0
HFD2_k127_3973048_8 Pyridoxamine 5'-phosphate oxidase K07006 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000008267 111.0
HFD2_k127_3978484_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 9.135e-267 828.0
HFD2_k127_3978484_1 poly(R)-hydroxyalkanoic acid synthase K03821 - - 3.486e-256 802.0
HFD2_k127_3978484_10 COG0119 Isopropylmalate homocitrate citramalate synthases K01640 - 4.1.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008987 324.0
HFD2_k127_3978484_11 enoyl-CoA hydratase K13766,K15312 - 4.2.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 293.0
HFD2_k127_3978484_12 EVE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006193 242.0
HFD2_k127_3978484_13 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001912 256.0
HFD2_k127_3978484_14 cell division protein - - - 0.00000000000000000000000000000000000000000000002391 176.0
HFD2_k127_3978484_15 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000009327 172.0
HFD2_k127_3978484_16 TonB-dependent Receptor Plug Domain K02014 - - 0.0000000000000000000000000000000000000000001046 167.0
HFD2_k127_3978484_17 Thiol disulfide interchange protein K03673 - - 0.0000000000000000000000000000000000000000001371 175.0
HFD2_k127_3978484_18 transcriptional - - - 0.0000000000000000000000000000000000004828 143.0
HFD2_k127_3978484_19 OsmC-like protein - - - 0.000000000000000000000000000000002047 144.0
HFD2_k127_3978484_2 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 3.051e-233 739.0
HFD2_k127_3978484_20 thiolester hydrolase activity K17362 - - 0.00000000000000000000000000001942 132.0
HFD2_k127_3978484_21 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000000000000000009515 118.0
HFD2_k127_3978484_23 Receptor family ligand binding region K01999 - - 0.0000007452 50.0
HFD2_k127_3978484_24 Nitronate monooxygenase K00459 - 1.13.12.16 0.00004456 48.0
HFD2_k127_3978484_3 Arginyl-tRNA synthetase K01887 - 6.1.1.19 5.561e-218 697.0
HFD2_k127_3978484_4 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 2.296e-214 686.0
HFD2_k127_3978484_5 Acyl-CoA dehydrogenase, N-terminal domain K00253 - 1.3.8.4 8.98e-198 622.0
HFD2_k127_3978484_6 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004646 607.0
HFD2_k127_3978484_7 COG1960 Acyl-CoA dehydrogenases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 507.0
HFD2_k127_3978484_8 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 455.0
HFD2_k127_3978484_9 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 363.0
HFD2_k127_4001517_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 449.0
HFD2_k127_4001517_1 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 327.0
HFD2_k127_4001517_2 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000000000007885 197.0
HFD2_k127_4001517_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000005099 196.0
HFD2_k127_4001517_4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.000000000000000000000000000000008162 134.0
HFD2_k127_4001517_5 COG1463 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.00000000000000000000000000009346 132.0
HFD2_k127_4001517_6 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000000000000419 115.0
HFD2_k127_4001517_7 Permease MlaE K02066 - - 0.000000000000000000000005287 116.0
HFD2_k127_4001517_8 ABC transporter - - - 0.000000000002584 79.0
HFD2_k127_400760_0 AAA domain (Cdc48 subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003361 490.0
HFD2_k127_400760_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 402.0
HFD2_k127_400760_10 Cytochrome c class I - - - 0.000000000000000000000000009869 113.0
HFD2_k127_400760_11 Part of a membrane complex involved in electron transport K03616 - - 0.000000000000000000000001007 110.0
HFD2_k127_400760_12 Cytochrome c - - - 0.000000000000000000001431 103.0
HFD2_k127_400760_13 acr, cog1678 K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000001023 60.0
HFD2_k127_400760_2 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 342.0
HFD2_k127_400760_3 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 321.0
HFD2_k127_400760_4 Polysaccharide deacetylase K22278 - 3.5.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007682 290.0
HFD2_k127_400760_5 alanine dehydrogenase K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001592 270.0
HFD2_k127_400760_6 Flavodoxin domain K00230 - 1.3.5.3 0.000000000000000000000000000000000000000000000000000000000000001042 222.0
HFD2_k127_400760_7 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000002936 203.0
HFD2_k127_400760_8 Domain of unknown function (DUF1841) - - - 0.00000000000000000000000000000000000000000000003298 173.0
HFD2_k127_400760_9 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000003641 118.0
HFD2_k127_4040324_0 Sulfate transporter antisigma-factor antagonist STAS K03321 - - 5.055e-231 736.0
HFD2_k127_4040324_1 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 608.0
HFD2_k127_4040324_2 Dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 425.0
HFD2_k127_4040324_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 380.0
HFD2_k127_4066073_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520 - 1.2.5.3 0.0 1042.0
HFD2_k127_4066073_1 Prolyl oligopeptidase family K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006045 389.0
HFD2_k127_4066073_2 Dehydrogenase K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000004845 245.0
HFD2_k127_4066073_3 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000001691 242.0
HFD2_k127_4066073_4 Uncharacterized protein conserved in bacteria (DUF2330) - - - 0.0000000000000000000000000000000000000000000000000000000001057 233.0
HFD2_k127_4066073_5 [2Fe-2S] binding domain - - - 0.0000000000000000000000000000000000000000000000000000000002534 218.0
HFD2_k127_4066073_6 protein conserved in bacteria - - - 0.00000000000004652 84.0
HFD2_k127_4072673_0 CO dehydrogenase flavoprotein C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007194 406.0
HFD2_k127_4072673_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 359.0
HFD2_k127_4072673_2 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 316.0
HFD2_k127_4072673_3 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 332.0
HFD2_k127_4072673_4 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 317.0
HFD2_k127_4072673_5 2Fe-2S -binding domain K03518,K13480,K13483 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000007143 236.0
HFD2_k127_4072673_6 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.00000000000000000000000000000000000000000000000000000005762 200.0
HFD2_k127_4072673_7 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000005687 212.0
HFD2_k127_4072673_8 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000002627 180.0
HFD2_k127_4072673_9 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000007096 86.0
HFD2_k127_41017_0 ABC-type dipeptide transport system, periplasmic component K02035 - - 5.916e-196 642.0
HFD2_k127_41017_1 Metal-dependent amidase aminoacylase carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 479.0
HFD2_k127_41017_2 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 459.0
HFD2_k127_41017_3 family UPF0324 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 406.0
HFD2_k127_41017_4 A G-specific K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004354 349.0
HFD2_k127_4110376_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007698 491.0
HFD2_k127_4110376_1 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009284 312.0
HFD2_k127_4110376_2 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000002047 229.0
HFD2_k127_4110376_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000003601 233.0
HFD2_k127_4151239_0 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 394.0
HFD2_k127_4151239_1 Protein of unknown function (DUF1847) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000347 346.0
HFD2_k127_4151239_2 abc transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006213 307.0
HFD2_k127_4152060_0 COG1008 NADH ubiquinone oxidoreductase subunit 4 (chain M) K00342 - 1.6.5.3 3.776e-234 750.0
HFD2_k127_4152060_1 chain 5 L K00341 - 1.6.5.3 4.03e-197 625.0
HFD2_k127_4152060_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 547.0
HFD2_k127_4152060_3 NUDIX domain K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000001054 205.0
HFD2_k127_4244726_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046487,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 2.829e-286 908.0
HFD2_k127_4244726_1 Amidohydrolase family K01464,K01465,K01466 - 3.5.2.2,3.5.2.3,3.5.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000772 609.0
HFD2_k127_4244726_2 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 338.0
HFD2_k127_4244726_3 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009603 274.0
HFD2_k127_4244726_4 Cobalamin synthesis protein cobW C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000001381 229.0
HFD2_k127_4244726_5 flavin adenine dinucleotide binding - - - 0.00000000000000000000000982 104.0
HFD2_k127_4244726_6 PFAM Isochorismatase - - - 0.000000000000001898 84.0
HFD2_k127_4330273_0 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 2.816e-215 680.0
HFD2_k127_4330273_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999,K11959 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 491.0
HFD2_k127_4330273_10 - - - - 0.000000000000000000000000001244 118.0
HFD2_k127_4330273_11 Acetyltransferase (GNAT) family K00619 - 2.3.1.1 0.000000000000000000000000002159 116.0
HFD2_k127_4330273_12 Tripartite ATP-independent periplasmic transporters, DctQ component K21394 - - 0.0000000000303 76.0
HFD2_k127_4330273_2 Branched-chain amino acid transport system permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 414.0
HFD2_k127_4330273_3 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 372.0
HFD2_k127_4330273_4 ATPases associated with a variety of cellular activities K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006565 305.0
HFD2_k127_4330273_5 COG1593 TRAP-type C4-dicarboxylate transport system large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003769 306.0
HFD2_k127_4330273_6 COG1538 Outer membrane protein K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002098 284.0
HFD2_k127_4330273_7 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000001929 217.0
HFD2_k127_4330273_8 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000001836 186.0
HFD2_k127_4330273_9 transporter solute receptor, DctP family - - - 0.00000000000000000000000000000000000000000008813 176.0
HFD2_k127_4333779_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.0000000000000000000000000000000000000000000000000000000000000003118 236.0
HFD2_k127_4333779_1 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000003901 163.0
HFD2_k127_4333779_2 - - - - 0.000000000000000000000000000000000003849 148.0
HFD2_k127_4368220_0 Pfam Sulfatase K01133 - 3.1.6.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 603.0
HFD2_k127_4368220_1 AAA family ATPase, CDC48 subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007687 411.0
HFD2_k127_4368220_11 - - - - 0.00001275 47.0
HFD2_k127_4368220_2 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009991 402.0
HFD2_k127_4368220_3 PFAM NAD binding domain of 6-phosphogluconate dehydrogenase K00020,K00042,K19647 - 1.1.1.291,1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 371.0
HFD2_k127_4368220_4 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001015 271.0
HFD2_k127_4368220_5 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006472 271.0
HFD2_k127_4368220_6 Activator of Hsp90 ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001628 250.0
HFD2_k127_4368220_7 Sulphur transport K07112 - - 0.00000000000000000000000000000000000000000000000000000000000000000258 229.0
HFD2_k127_4368220_8 Glyoxalase-like domain K08234 - - 0.00000000000000000000000000000000000000000000000000000002975 200.0
HFD2_k127_4368220_9 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000444 93.0
HFD2_k127_4393120_0 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005547 249.0
HFD2_k127_4393120_1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.000000000000000000000000000000000000000000000000000000000000003292 225.0
HFD2_k127_4393120_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000006098 124.0
HFD2_k127_4419104_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 602.0
HFD2_k127_4419104_1 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 509.0
HFD2_k127_4419104_10 small protein containing a coiled-coil domain - - - 0.00000000000002869 74.0
HFD2_k127_4419104_2 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 473.0
HFD2_k127_4419104_3 aminotransferase class V K01556 - 3.7.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004065 350.0
HFD2_k127_4419104_4 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000172 253.0
HFD2_k127_4419104_5 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000006331 235.0
HFD2_k127_4419104_6 Haloacid dehalogenase-like hydrolase K20866 - 3.1.3.10 0.0000000000000000000000000000000000000000000000004715 187.0
HFD2_k127_4419104_7 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000000000001121 178.0
HFD2_k127_4419104_8 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000002571 174.0
HFD2_k127_4419104_9 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000007421 145.0
HFD2_k127_4451453_0 Protein of unknown function (DUF560) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006829 351.0
HFD2_k127_4451453_1 FecR protein - - - 0.0000000000000000000000000000000000000000005575 162.0
HFD2_k127_4452807_0 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 520.0
HFD2_k127_4452807_1 Ethanolamine utilisation protein EutA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006924 442.0
HFD2_k127_4452807_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006716 383.0
HFD2_k127_4452807_3 Amidohydrolase K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005462 376.0
HFD2_k127_4452807_4 Sir2 family K12410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 311.0
HFD2_k127_4452807_5 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009832 291.0
HFD2_k127_4452807_6 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.0000000000000000000000000000000000000000001386 160.0
HFD2_k127_4452807_7 - - - - 0.000000000000000000000000000000009319 131.0
HFD2_k127_4470033_0 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 6.931e-234 731.0
HFD2_k127_4470033_1 Aminotransferase class I and II K14261 - - 6.797e-223 694.0
HFD2_k127_4470033_10 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 390.0
HFD2_k127_4470033_11 hydrolase activity, acting on ester bonds K01561 - 3.8.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 346.0
HFD2_k127_4470033_12 PFAM Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003513 327.0
HFD2_k127_4470033_13 PFAM formyl transferase domain protein K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 337.0
HFD2_k127_4470033_14 Histone methylation protein DOT1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000003426 243.0
HFD2_k127_4470033_15 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000002602 241.0
HFD2_k127_4470033_16 - - - - 0.00000000000000000000000000000000000000000000000004134 196.0
HFD2_k127_4470033_17 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.000000000000000000000000000000000000001501 166.0
HFD2_k127_4470033_18 Hemerythrin HHE cation binding domain - - - 0.00000000000000000000000000000000000001341 150.0
HFD2_k127_4470033_19 Protein of unknown function (DUF498/DUF598) - - - 0.000000000000000000000000000000000001016 145.0
HFD2_k127_4470033_2 Cytochrome c554 and c-prime - - - 2.883e-213 689.0
HFD2_k127_4470033_20 Cytochrome c - - - 0.0000000000000000000000000000000008903 143.0
HFD2_k127_4470033_21 Iron-binding zinc finger CDGSH type - - - 0.00000000000000000000000000000003709 128.0
HFD2_k127_4470033_22 Response regulator, receiver - - - 0.00000000000000000000001926 104.0
HFD2_k127_4470033_23 Cytochrome c - - - 0.0000000000000000000001944 110.0
HFD2_k127_4470033_24 Cyclic nucleotide-monophosphate binding domain K21563 - - 0.000000000000000000004849 102.0
HFD2_k127_4470033_25 cytochrome - - - 0.000000000000000000005515 106.0
HFD2_k127_4470033_26 - - - - 0.0000000000000000001777 100.0
HFD2_k127_4470033_27 cytochrome c5 - - - 0.0000000000000000159 92.0
HFD2_k127_4470033_28 COG2863 Cytochrome c553 - - - 0.00000000000000003212 94.0
HFD2_k127_4470033_29 Redoxin K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0000000000000001508 81.0
HFD2_k127_4470033_3 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 627.0
HFD2_k127_4470033_30 Cytochrome c K08738 - - 0.00000000000001464 77.0
HFD2_k127_4470033_31 PFAM cytochrome c, class I K08738 - - 0.000000000001943 81.0
HFD2_k127_4470033_32 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000002339 78.0
HFD2_k127_4470033_33 cytochrome C K08738 - - 0.0000000004143 67.0
HFD2_k127_4470033_34 Cytochrome c - - - 0.0000283 56.0
HFD2_k127_4470033_35 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0002654 48.0
HFD2_k127_4470033_4 Threonine synthase K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 578.0
HFD2_k127_4470033_5 Nad-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 538.0
HFD2_k127_4470033_6 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 507.0
HFD2_k127_4470033_7 Pfam Glycosyl transferase family 2 K10012 - 2.4.2.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009504 459.0
HFD2_k127_4470033_8 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 409.0
HFD2_k127_4470033_9 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 391.0
HFD2_k127_448736_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00244 - 1.3.5.4 2.53e-278 874.0
HFD2_k127_448736_1 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000422 508.0
HFD2_k127_448736_2 2Fe-2S iron-sulfur cluster binding domain K00245 - 1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 381.0
HFD2_k127_448736_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000252 257.0
HFD2_k127_448736_4 Fumarate reductase subunit D K00247 - - 0.0000000000000000000000000000005398 131.0
HFD2_k127_448736_5 Fumarate reductase subunit C K00246 - - 0.0000000000000000000000007975 117.0
HFD2_k127_448736_6 cytochrome C K08738 - - 0.0000000000001293 75.0
HFD2_k127_448736_7 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.00000000001196 77.0
HFD2_k127_4502386_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006161 476.0
HFD2_k127_4502386_1 Belongs to the peptidase S16 family - - - 0.000000000000000000000000000000000000000000000000000000000000122 221.0
HFD2_k127_450879_0 benzoyl-CoA oxygenase K15512 - 1.14.13.208 8.782e-244 759.0
HFD2_k127_450879_1 enoyl-CoA hydratase K15513 - 4.1.2.44 2.274e-228 734.0
HFD2_k127_450879_10 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000001491 116.0
HFD2_k127_450879_11 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.000000000000000004422 88.0
HFD2_k127_450879_12 LysR family K21703 - - 0.000000000000000005134 92.0
HFD2_k127_450879_13 Universal stress protein family - - - 0.0000000000000002955 93.0
HFD2_k127_450879_14 PFAM 2-nitropropane dioxygenase NPD K00459 - 1.13.12.16 0.000000000000009449 80.0
HFD2_k127_450879_15 Haem-degrading - - - 0.000001227 59.0
HFD2_k127_450879_2 AsmA family K07289,K07290 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 578.0
HFD2_k127_450879_3 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 503.0
HFD2_k127_450879_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 441.0
HFD2_k127_450879_5 membrane protein, TerC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001683 263.0
HFD2_k127_450879_6 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K15546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002983 257.0
HFD2_k127_450879_7 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000003521 225.0
HFD2_k127_450879_8 Flavodoxin - - - 0.00000000000000000000000000000000000000000000000000001484 193.0
HFD2_k127_450879_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000003337 153.0
HFD2_k127_4512539_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 5.654e-278 862.0
HFD2_k127_4512539_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 510.0
HFD2_k127_4512539_2 D-alanyl-D-alanine carboxypeptidase K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 404.0
HFD2_k127_4512539_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000000000003026 174.0
HFD2_k127_4518527_0 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336 - 1.6.5.3 1.186e-273 860.0
HFD2_k127_4518527_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 8.297e-225 711.0
HFD2_k127_4518527_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 529.0
HFD2_k127_4518527_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009938 278.0
HFD2_k127_4518527_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002276 296.0
HFD2_k127_4518527_5 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000008334 267.0
HFD2_k127_4518527_6 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000008198 250.0
HFD2_k127_4518527_7 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000005003 244.0
HFD2_k127_4518527_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000000000001093 165.0
HFD2_k127_4546853_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 4.347e-320 994.0
HFD2_k127_4546853_1 4Fe-4S dicluster domain - - - 9.856e-237 751.0
HFD2_k127_4546853_10 Nitrate reductase delta subunit - - - 0.00000000000000000000000000000001203 147.0
HFD2_k127_4546853_11 Cysteine dioxygenase type I - - - 0.0000000000000000006857 101.0
HFD2_k127_4546853_12 Protein of unknown function (DUF3306) - - - 0.00000000000000002238 93.0
HFD2_k127_4546853_13 - - - - 0.0000001106 56.0
HFD2_k127_4546853_2 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 525.0
HFD2_k127_4546853_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006666 496.0
HFD2_k127_4546853_4 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K00850 - 2.7.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007193 432.0
HFD2_k127_4546853_5 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004828 386.0
HFD2_k127_4546853_6 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000044 385.0
HFD2_k127_4546853_7 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000000436 241.0
HFD2_k127_4546853_8 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000001057 231.0
HFD2_k127_4546853_9 Protein of unknown function (DUF3305) - - - 0.000000000000000000000000000000000000000001947 160.0
HFD2_k127_4549414_0 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 478.0
HFD2_k127_4549414_1 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 411.0
HFD2_k127_4549414_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009697 319.0
HFD2_k127_4549414_3 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 311.0
HFD2_k127_4549414_4 Membrane - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000001483 241.0
HFD2_k127_4549414_5 TIGRFAM Urea carboxylase-associated protein 1 K09967 - - 0.000000000000000000000000000000000000000000000000000000000000012 221.0
HFD2_k127_4549414_6 Protein of unknown function (DUF1328) - - - 0.00000000001862 74.0
HFD2_k127_4575863_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1325.0
HFD2_k127_4575863_1 Peptidase family M41 K03798 - - 6.92e-255 799.0
HFD2_k127_4575863_10 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000001443 194.0
HFD2_k127_4575863_11 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000007037 188.0
HFD2_k127_4575863_12 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000003124 141.0
HFD2_k127_4575863_13 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.0000000000000000000000000000000004186 148.0
HFD2_k127_4575863_14 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000004283 136.0
HFD2_k127_4575863_15 Uncharacterized ACR, COG1678 - - - 0.00000000000000000000348 104.0
HFD2_k127_4575863_16 Uncharacterized ACR, COG1678 K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000006512 102.0
HFD2_k127_4575863_2 PFAM Alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003621 619.0
HFD2_k127_4575863_3 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005907 535.0
HFD2_k127_4575863_4 Bacterial extracellular solute-binding protein K05772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009675 420.0
HFD2_k127_4575863_5 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 425.0
HFD2_k127_4575863_6 Methyltransferase small domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005242 297.0
HFD2_k127_4575863_7 ABC-type polar amino acid transport system ATPase component K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007818 280.0
HFD2_k127_4575863_8 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000001778 228.0
HFD2_k127_4575863_9 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.00000000000000000000000000000000000000000000000000000000000003989 229.0
HFD2_k127_4582572_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 3.968e-209 664.0
HFD2_k127_4582572_1 Major facilitator superfamily K08218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004858 607.0
HFD2_k127_4582572_2 Exodeoxyribonuclease III xth K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 365.0
HFD2_k127_4582572_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005909 342.0
HFD2_k127_4582572_4 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000002084 161.0
HFD2_k127_4582572_5 - - - - 0.000000000000000000000001228 112.0
HFD2_k127_4591591_0 Serine aminopeptidase, S33 - - - 1.341e-259 811.0
HFD2_k127_4591591_1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 1.207e-246 779.0
HFD2_k127_4591591_10 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006894 407.0
HFD2_k127_4591591_11 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 414.0
HFD2_k127_4591591_12 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007434 363.0
HFD2_k127_4591591_13 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 376.0
HFD2_k127_4591591_14 dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 319.0
HFD2_k127_4591591_15 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000674 302.0
HFD2_k127_4591591_16 Enoyl-CoA hydratase carnithine racemase K01692,K11264 - 4.1.1.41,4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000001954 278.0
HFD2_k127_4591591_17 synthase K01719 - 4.2.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000001339 254.0
HFD2_k127_4591591_18 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001007 270.0
HFD2_k127_4591591_19 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003059 251.0
HFD2_k127_4591591_2 FAD dependent oxidoreductase - - - 5.294e-230 737.0
HFD2_k127_4591591_20 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000007142 244.0
HFD2_k127_4591591_21 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000004986 231.0
HFD2_k127_4591591_22 Cupin domain - - - 0.00000000000000000000000000000000000004583 148.0
HFD2_k127_4591591_23 PFAM CHRD domain containing protein - - - 0.000000000000000000000000000000000007546 141.0
HFD2_k127_4591591_24 Transcriptional regulator K05799 - - 0.0000000000000000000000000000000001736 143.0
HFD2_k127_4591591_25 - - - - 0.00000000000000000000000000000000187 147.0
HFD2_k127_4591591_26 Amidohydrolase K03392 - 4.1.1.45 0.00000000000000000003086 90.0
HFD2_k127_4591591_27 EF hand - - - 0.00002967 53.0
HFD2_k127_4591591_28 - - - - 0.0002848 53.0
HFD2_k127_4591591_3 Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats - - - 1.707e-199 631.0
HFD2_k127_4591591_4 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 519.0
HFD2_k127_4591591_5 phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 496.0
HFD2_k127_4591591_6 III protein, CoA-transferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 488.0
HFD2_k127_4591591_7 gluconolactonase K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006497 468.0
HFD2_k127_4591591_8 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 440.0
HFD2_k127_4591591_9 Belongs to the amidase family K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 429.0
HFD2_k127_460644_0 Transmembrane secretion effector - - - 8.552e-215 687.0
HFD2_k127_460644_1 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 5.782e-212 667.0
HFD2_k127_460644_10 ChrR Cupin-like domain - - - 0.000000000000000000000000000000000000000000000006914 177.0
HFD2_k127_460644_11 PFAM MaoC like domain - - - 0.0000000000000000000000000000008345 136.0
HFD2_k127_460644_12 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.0000000006372 69.0
HFD2_k127_460644_13 NMT1/THI5 like K02051 - - 0.00000004475 55.0
HFD2_k127_460644_2 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 533.0
HFD2_k127_460644_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0000226,GO:0001817,GO:0001819,GO:0001906,GO:0001907,GO:0002376,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0004365,GO:0004857,GO:0004866,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006417,GO:0006464,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007010,GO:0007017,GO:0008017,GO:0008092,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009435,GO:0009605,GO:0009607,GO:0009620,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009987,GO:0010033,GO:0010466,GO:0010468,GO:0010506,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010941,GO:0010942,GO:0010951,GO:0012501,GO:0012505,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016241,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016769,GO:0016903,GO:0017014,GO:0017144,GO:0017148,GO:0018119,GO:0018130,GO:0018193,GO:0018198,GO:0019222,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019538,GO:0019637,GO:0019674,GO:0019693,GO:0019730,GO:0019752,GO:0019828,GO:0019904,GO:0030162,GO:0030234,GO:0030414,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031341,GO:0031343,GO:0031640,GO:0031647,GO:0031965,GO:0031967,GO:0031975,GO:0032268,GO:0032269,GO:0032787,GO:0032879,GO:0032880,GO:0032991,GO:0034097,GO:0034248,GO:0034249,GO:0034341,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035605,GO:0035606,GO:0035821,GO:0036094,GO:0036211,GO:0042221,GO:0042802,GO:0042866,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043086,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0043436,GO:0043891,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044364,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0045087,GO:0045861,GO:0046031,GO:0046034,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050662,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050790,GO:0050794,GO:0050821,GO:0050832,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051287,GO:0051336,GO:0051346,GO:0051402,GO:0051701,GO:0051702,GO:0051704,GO:0051707,GO:0051709,GO:0051712,GO:0051716,GO:0051817,GO:0051818,GO:0051851,GO:0051852,GO:0051873,GO:0051883,GO:0052040,GO:0052042,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0061134,GO:0061135,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0061844,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070887,GO:0070997,GO:0071310,GO:0071345,GO:0071346,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090087,GO:0090407,GO:0097159,GO:0097452,GO:0097718,GO:0098542,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:1990904,GO:2000112,GO:2000113 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 533.0
HFD2_k127_460644_4 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 440.0
HFD2_k127_460644_5 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 413.0
HFD2_k127_460644_6 Cobalamin-independent synthase, Catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009305 404.0
HFD2_k127_460644_7 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000855 367.0
HFD2_k127_460644_8 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000001196 207.0
HFD2_k127_460644_9 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000001932 190.0
HFD2_k127_4688171_0 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004064 269.0
HFD2_k127_4688171_1 cyclase dehydrase - - - 0.00000000000000000000000000000000000000000000000000000000000000234 220.0
HFD2_k127_4688171_2 Cys/Met metabolism PLP-dependent enzyme K01760 - 4.4.1.8 0.000000000000000000000000000000000000000000000000000003083 193.0
HFD2_k127_4688171_3 Domain of unknown function (DUF4124) - - - 0.00000000000000000000000000000000000001925 151.0
HFD2_k127_4688171_4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.0000000000000000000000000000165 118.0
HFD2_k127_4688171_5 Belongs to the UPF0125 (RnfH) family K09801 - - 0.0000000000000000000000015 106.0
HFD2_k127_4711874_0 TIGRFAM ATP-dependent Clp protease ATP-binding subunit clpA K03694 - - 0.0 1195.0
HFD2_k127_4711874_1 Isocitrate dehydrogenase K00031 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 9.089e-224 698.0
HFD2_k127_4711874_2 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 454.0
HFD2_k127_4711874_3 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000000000000000006766 166.0
HFD2_k127_4711874_4 Cold shock protein K03704 - - 0.000000000000000000000000007213 114.0
HFD2_k127_4711874_5 peptidyl-tyrosine sulfation - - - 0.00000000000000000006856 91.0
HFD2_k127_4711874_6 - - - - 0.000000006889 70.0
HFD2_k127_4736020_0 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 1.538e-207 652.0
HFD2_k127_4736020_1 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000915 266.0
HFD2_k127_4736020_2 - - - - 0.000000000000000000000000000000000000000005661 160.0
HFD2_k127_4736020_3 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.000000000001938 68.0
HFD2_k127_4774793_0 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 381.0
HFD2_k127_4774793_1 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 341.0
HFD2_k127_4774793_2 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 335.0
HFD2_k127_4774793_3 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 295.0
HFD2_k127_4774793_4 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000002885 209.0
HFD2_k127_4777418_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003781 444.0
HFD2_k127_4777418_1 Bacterial regulatory helix-turn-helix protein, lysR family K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003915 286.0
HFD2_k127_4777418_2 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000000000000006837 143.0
HFD2_k127_4779075_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 9.195e-264 821.0
HFD2_k127_4779075_1 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 1.193e-257 799.0
HFD2_k127_4779075_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 2.053e-237 747.0
HFD2_k127_4779075_3 Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 611.0
HFD2_k127_4779075_4 ABC-type glycine betaine transport system K05845,K05846 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000578 537.0
HFD2_k127_4779075_5 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 467.0
HFD2_k127_4779075_6 Peptidase C26 K07010 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 288.0
HFD2_k127_4779075_7 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.00000000000000000000000000007331 121.0
HFD2_k127_4781162_0 PFAM conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004086 445.0
HFD2_k127_4781162_1 Dehydrogenase K15054 - 1.1.99.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007087 399.0
HFD2_k127_4781162_2 FAD binding domain K00480,K16839,K20940,K22270 - 1.14.13.1,1.14.13.113,1.14.13.218,1.14.13.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008903 369.0
HFD2_k127_4781162_3 Belongs to the DapA family K01714 - 4.3.3.7 0.000000000000000000005639 94.0
HFD2_k127_4781162_4 Ring hydroxylating subunit beta family protein 1 - - - 0.000000000000000000005705 98.0
HFD2_k127_4781162_5 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.000703 42.0
HFD2_k127_4786722_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1198.0
HFD2_k127_4786722_1 ABC transporter K06020 - 3.6.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000488 392.0
HFD2_k127_4786722_2 PFAM Outer membrane efflux protein K15725 - - 0.0000000000000000000000000000000000002744 156.0
HFD2_k127_4786722_3 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K12976 - - 0.00000000000000000000000000000002637 131.0
HFD2_k127_4790634_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 1.681e-197 622.0
HFD2_k127_4790634_1 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 540.0
HFD2_k127_4790634_11 Transcriptional regulator - - - 0.00000000000000000000000000000000001047 138.0
HFD2_k127_4790634_12 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000000000000000000001013 135.0
HFD2_k127_4790634_13 DegT/DnrJ/EryC1/StrS aminotransferase family K13010 - 2.6.1.102 0.000000000003363 71.0
HFD2_k127_4790634_2 (ABC) transporter K02022,K06147,K06148 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008032 523.0
HFD2_k127_4790634_3 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 518.0
HFD2_k127_4790634_4 Belongs to the DegT DnrJ EryC1 family K13017 - 2.6.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 499.0
HFD2_k127_4790634_5 ADP-glyceromanno-heptose 6-epimerase activity K01710,K01784 - 4.2.1.46,5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 503.0
HFD2_k127_4790634_6 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005301 437.0
HFD2_k127_4790634_7 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008492 307.0
HFD2_k127_4790634_8 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008357 281.0
HFD2_k127_4790634_9 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000000002091 253.0
HFD2_k127_48226_0 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 535.0
HFD2_k127_48226_1 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 470.0
HFD2_k127_48226_2 histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 419.0
HFD2_k127_48226_3 PFAM ATPase associated with various cellular activities AAA_3 K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 414.0
HFD2_k127_48226_4 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA K06917 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 398.0
HFD2_k127_48226_5 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000001871 152.0
HFD2_k127_48226_6 Thioredoxin-like - - - 0.0000000000000001855 90.0
HFD2_k127_4834818_0 General secretory system II protein E domain protein K02454,K02652,K12276 - - 0.0 1134.0
HFD2_k127_4834818_1 CHASE2 K01768 - 4.6.1.1 1.676e-265 836.0
HFD2_k127_4834818_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. K01120 - 3.1.4.17 1.517e-238 749.0
HFD2_k127_4834818_3 cAMP phosphodiesterases class-II K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 368.0
HFD2_k127_4834818_4 cyclic nucleotide-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007794 296.0
HFD2_k127_4834818_5 O-linked N-acetylglucosamine transferase SPINDLY family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005818 254.0
HFD2_k127_4834818_6 (FHA) domain - - - 0.000000000000000000000000000000000004593 141.0
HFD2_k127_483554_0 aminopeptidase K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 603.0
HFD2_k127_483554_1 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 558.0
HFD2_k127_483554_2 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005341 446.0
HFD2_k127_483554_3 Nucleotidyl transferase K00992 - 2.7.7.99 0.0000000000000000000000000000000000000000000000000000000000000000000008614 252.0
HFD2_k127_483554_4 UbiH UbiF VisC COQ6 family K03185 - - 0.00000000000000000000000000000000000000000000000000000000000000000001902 245.0
HFD2_k127_483554_5 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00000000000000008374 82.0
HFD2_k127_4849801_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1109.0
HFD2_k127_4854750_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 8.842e-216 676.0
HFD2_k127_4854750_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004966 606.0
HFD2_k127_4854750_10 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000006479 175.0
HFD2_k127_4854750_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 536.0
HFD2_k127_4854750_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 489.0
HFD2_k127_4854750_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 441.0
HFD2_k127_4854750_5 COG3170 Tfp pilus assembly protein FimV K08086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009964 454.0
HFD2_k127_4854750_6 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007342 346.0
HFD2_k127_4854750_7 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008468 361.0
HFD2_k127_4854750_8 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 292.0
HFD2_k127_4854750_9 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000002983 231.0
HFD2_k127_4867538_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.512e-300 930.0
HFD2_k127_4867538_1 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 384.0
HFD2_k127_4867538_2 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000007296 250.0
HFD2_k127_4867538_3 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000789 228.0
HFD2_k127_4867538_4 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000001215 181.0
HFD2_k127_4867538_5 Domain of unknown function (DUF4845) - - - 0.00000000000000001313 89.0
HFD2_k127_4867538_6 PFAM glutaredoxin 2 - - - 0.0000000000000001237 81.0
HFD2_k127_4889725_0 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007834 406.0
HFD2_k127_4889725_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 406.0
HFD2_k127_4889725_10 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000000000000009198 109.0
HFD2_k127_4889725_2 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005851 374.0
HFD2_k127_4889725_3 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 339.0
HFD2_k127_4889725_4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005248 341.0
HFD2_k127_4889725_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 291.0
HFD2_k127_4889725_6 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000001436 201.0
HFD2_k127_4889725_7 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 - - 0.000000000000000000000000000000000000000000009671 168.0
HFD2_k127_4889725_8 Psort location Cytoplasmic, score K01523 - 3.6.1.31 0.0000000000000000000000000000004389 132.0
HFD2_k127_4889725_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.000000000000000000000000002044 116.0
HFD2_k127_4915981_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1266.0
HFD2_k127_4915981_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 488.0
HFD2_k127_4915981_2 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 482.0
HFD2_k127_4915981_3 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 427.0
HFD2_k127_4915981_4 General function prediction only K06923 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009549 375.0
HFD2_k127_4915981_5 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 331.0
HFD2_k127_4915981_6 Peptidase family M23 K08259 - 3.4.24.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 303.0
HFD2_k127_4915981_7 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000001149 230.0
HFD2_k127_4915981_8 Protein of unknown function (DUF721) - - - 0.0000000001133 68.0
HFD2_k127_4917707_0 Belongs to the glutamine synthetase family K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 613.0
HFD2_k127_4917707_1 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009826 481.0
HFD2_k127_4917707_10 - - - - 0.000000002085 72.0
HFD2_k127_4917707_2 Aldo/keto reductase family K05275 - 1.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002038 426.0
HFD2_k127_4917707_3 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002664 268.0
HFD2_k127_4917707_4 Protein of unknown function (DUF2848) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004962 246.0
HFD2_k127_4917707_5 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000003192 182.0
HFD2_k127_4917707_6 Protein conserved in bacteria K09984 - - 0.0000000000000000000000000000000000000000000004164 178.0
HFD2_k127_4917707_7 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000011 164.0
HFD2_k127_4917707_8 Drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000002494 172.0
HFD2_k127_4917707_9 Protein of unknown function (DUF2846) - - - 0.0000000000000000000000000000000000000000001446 163.0
HFD2_k127_4930709_0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 391.0
HFD2_k127_4930709_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000002155 213.0
HFD2_k127_4930709_2 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000004517 153.0
HFD2_k127_4932960_0 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 541.0
HFD2_k127_4932960_1 OmpA-like transmembrane domain - - - 0.0000000000000000000000000004232 123.0
HFD2_k127_4932960_2 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K03286 - - 0.00000000000000000000000002146 118.0
HFD2_k127_4932960_3 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K03286 - - 0.000000000000000000003311 102.0
HFD2_k127_4932960_4 Amidohydrolase K14333 - 4.1.1.46 0.00000000000000001892 83.0
HFD2_k127_4934714_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009798 562.0
HFD2_k127_4934714_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 550.0
HFD2_k127_4934714_10 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000007507 221.0
HFD2_k127_4934714_11 MlaC protein K07323 - - 0.00000000000000000000000000000000000000000000000000000000000004584 227.0
HFD2_k127_4934714_12 PFAM Mammalian cell entry related domain protein K02067 - - 0.000000000000000000000000000000000000000000000000000000002691 216.0
HFD2_k127_4934714_13 Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5- (5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000288 198.0
HFD2_k127_4934714_14 Belongs to the BolA IbaG family - - - 0.000000000000000000000000008669 122.0
HFD2_k127_4934714_15 STAS domain K07122 - - 0.00000000109 69.0
HFD2_k127_4934714_2 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 413.0
HFD2_k127_4934714_3 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005362 411.0
HFD2_k127_4934714_4 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005769 395.0
HFD2_k127_4934714_5 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 349.0
HFD2_k127_4934714_6 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009613 312.0
HFD2_k127_4934714_7 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 314.0
HFD2_k127_4934714_8 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001324 278.0
HFD2_k127_4934714_9 VacJ family lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000000000002127 246.0
HFD2_k127_4950932_0 DNA ligase K01971 - 6.5.1.1 7.117e-239 765.0
HFD2_k127_4950932_1 Transport of potassium into the cell K03549 - - 6.265e-221 696.0
HFD2_k127_4950932_10 Belongs to the UPF0337 (CsbD) family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000001487 109.0
HFD2_k127_4950932_11 - - - - 0.000000000000000000000002871 119.0
HFD2_k127_4950932_12 - - - - 0.0000000000000001305 86.0
HFD2_k127_4950932_13 BON domain - - - 0.000000000000000633 81.0
HFD2_k127_4950932_15 Protein of unknown function (DUF1328) - - - 0.0000000000001705 71.0
HFD2_k127_4950932_16 ribosome binding - - - 0.000000004276 61.0
HFD2_k127_4950932_17 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000003492 62.0
HFD2_k127_4950932_2 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 3.201e-210 661.0
HFD2_k127_4950932_3 His Kinase A (phosphoacceptor) domain - - - 1.33e-204 670.0
HFD2_k127_4950932_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006768 426.0
HFD2_k127_4950932_5 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 412.0
HFD2_k127_4950932_6 Bacterioferritin (cytochrome b1) K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001535 263.0
HFD2_k127_4950932_7 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000001152 241.0
HFD2_k127_4950932_8 Protein of unknown function (DUF421) - - - 0.00000000000000000000000000000000000000000000000001668 188.0
HFD2_k127_4950932_9 PAS fold - - - 0.000000000000000000000000000000000000000216 163.0
HFD2_k127_4982657_0 histidine kinase A domain protein - - - 0.0 1058.0
HFD2_k127_4982657_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.022e-250 792.0
HFD2_k127_4982657_2 COG2148 Sugar transferases involved in lipopolysaccharide synthesis K03606 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 509.0
HFD2_k127_4982657_3 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003761 516.0
HFD2_k127_4982657_4 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 329.0
HFD2_k127_4982657_5 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001335 278.0
HFD2_k127_4982657_6 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000003564 119.0
HFD2_k127_4982657_7 PFAM VanZ like family - - - 0.000000002186 63.0
HFD2_k127_5021552_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 392.0
HFD2_k127_5021552_1 FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000001193 262.0
HFD2_k127_5078494_0 4Fe-4S single cluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007074 599.0
HFD2_k127_5078494_1 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 424.0
HFD2_k127_5078494_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007293 343.0
HFD2_k127_5078494_3 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001264 282.0
HFD2_k127_5078494_4 Protein of unknown function (DUF938) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002088 252.0
HFD2_k127_5078494_5 Competence-damaged protein K03743 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000004132 189.0
HFD2_k127_5078494_6 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000000000000000000000000000000003729 188.0
HFD2_k127_5078494_7 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.00000000000000000000000000000000000000000000001126 184.0
HFD2_k127_5078494_8 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000001406 151.0
HFD2_k127_5078494_9 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000004395 141.0
HFD2_k127_5156467_0 protein synthesis factor, GTP-binding K06207 - - 9.423e-303 937.0
HFD2_k127_5156467_1 Tripartite tricarboxylate transporter TctA family K07793 - - 8.545e-210 672.0
HFD2_k127_5156467_10 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000002347 233.0
HFD2_k127_5156467_11 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000001514 201.0
HFD2_k127_5156467_12 Tripartite tricarboxylate transporter TctB family K07794 - - 0.00000000000000000001735 106.0
HFD2_k127_5156467_13 Domain of unknown function (DUF4340) - - - 0.0000000000000004944 92.0
HFD2_k127_5156467_2 PhoD-like phosphatase, N-terminal domain K01113 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 488.0
HFD2_k127_5156467_3 phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 450.0
HFD2_k127_5156467_4 Fructose-bisphosphate aldolase class-I K01623 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 381.0
HFD2_k127_5156467_5 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 370.0
HFD2_k127_5156467_6 ABC-type uncharacterized transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 368.0
HFD2_k127_5156467_7 PFAM conserved K07795 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003811 347.0
HFD2_k127_5156467_8 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000824 333.0
HFD2_k127_5156467_9 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003112 295.0
HFD2_k127_5180438_0 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases K00174 - 1.2.7.11,1.2.7.3 1.55e-209 666.0
HFD2_k127_5180438_1 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 479.0
HFD2_k127_5180438_2 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 343.0
HFD2_k127_5180438_3 Bifunctional enoyl-CoA hydratase phosphate acetyltransferase K00625 - 2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000001032 267.0
HFD2_k127_5180438_4 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009491 266.0
HFD2_k127_5180438_5 electron transfer activity K03737,K05337 - 1.2.7.1 0.000005355 59.0
HFD2_k127_5207744_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 4.469e-209 668.0
HFD2_k127_5207744_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009771 514.0
HFD2_k127_5207744_2 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 492.0
HFD2_k127_5207744_3 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007534 386.0
HFD2_k127_5207744_4 PFAM PTS system fructose subfamily IIA component K02821 - 2.7.1.194 0.00000000000000000000000000000008135 141.0
HFD2_k127_5207744_5 Phosphotransferase System K11189 - - 0.0000000000000000000000000000004147 124.0
HFD2_k127_5207744_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00001248 47.0
HFD2_k127_5219441_0 Protein of unknown function - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 392.0
HFD2_k127_5219441_1 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01501,K11206 - 3.5.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 328.0
HFD2_k127_5219441_2 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006174 285.0
HFD2_k127_5220518_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 4.719e-226 710.0
HFD2_k127_5220518_1 response regulator K02481 - - 2.969e-205 674.0
HFD2_k127_5220518_10 response regulator - - - 0.0000000001698 70.0
HFD2_k127_5220518_11 Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) K03620,K08354 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000002064 64.0
HFD2_k127_5220518_2 Histidine kinase K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 544.0
HFD2_k127_5220518_3 2 iron, 2 sulfur cluster binding K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 458.0
HFD2_k127_5220518_4 denitrification pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004229 285.0
HFD2_k127_5220518_5 cytochrome - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002643 265.0
HFD2_k127_5220518_6 Transposase IS200 like K07491 - - 0.0000000000000000000000000000000000000000000000000000000000001948 220.0
HFD2_k127_5220518_7 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000004777 207.0
HFD2_k127_5220518_8 Pfam Response regulator receiver - - - 0.0000000000000000000000000000000000000000006277 165.0
HFD2_k127_5220518_9 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000002922 100.0
HFD2_k127_5236130_0 Alanine dehydrogenase/PNT, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000574 493.0
HFD2_k127_5236130_1 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003557 490.0
HFD2_k127_5236130_10 Acyl-CoA dehydrogenase, C-terminal domain K16047 - 1.14.14.12 0.0000000000000000000000000000000000002109 148.0
HFD2_k127_5236130_11 - - - - 0.00000000000000000000000000000000009286 139.0
HFD2_k127_5236130_12 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000008642 142.0
HFD2_k127_5236130_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000002374 111.0
HFD2_k127_5236130_14 Rubredoxin - - - 0.00000000000000006962 95.0
HFD2_k127_5236130_15 PFAM Acyl-CoA dehydrogenase type 2 K16047 - 1.14.14.12 0.0000000000000001617 80.0
HFD2_k127_5236130_16 Sel1-like repeats. K07126,K13582 - - 0.0000001234 56.0
HFD2_k127_5236130_2 Acyl-CoA dehydrogenase, C-terminal domain K16047 - 1.14.14.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 362.0
HFD2_k127_5236130_3 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001565 285.0
HFD2_k127_5236130_4 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001691 238.0
HFD2_k127_5236130_5 TIGRFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000007782 227.0
HFD2_k127_5236130_6 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000000000000007841 223.0
HFD2_k127_5236130_7 CBS domain - - - 0.00000000000000000000000000000000000000000000000000001561 192.0
HFD2_k127_5236130_8 Cold shock K03704 - - 0.0000000000000000000000000000000000000001038 158.0
HFD2_k127_5236130_9 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000868 159.0
HFD2_k127_5246108_0 Zn-dependent protease with chaperone function K06013 - 3.4.24.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 475.0
HFD2_k127_5246108_1 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002524 265.0
HFD2_k127_5246108_2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000004079 200.0
HFD2_k127_5246108_3 diol metabolic process K01724 - 4.2.1.96 0.00000000000000000000000000000000000000001014 173.0
HFD2_k127_5246108_4 Putative prokaryotic signal transducing protein - - - 0.00000000000000000003142 99.0
HFD2_k127_5260381_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K02021,K11085 - - 1.211e-203 668.0
HFD2_k127_5260381_1 Glycosyltransferase family 9 (heptosyltransferase) K02849 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 410.0
HFD2_k127_5260381_2 Glycosyltransferase Family 4 K02844 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004278 353.0
HFD2_k127_5260381_3 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 329.0
HFD2_k127_5260381_4 Methyltransferase domain - - - 0.0000000000000000000000000000002281 130.0
HFD2_k127_5266883_0 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 505.0
HFD2_k127_5266883_1 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 394.0
HFD2_k127_5266883_2 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 325.0
HFD2_k127_5266883_3 Ring hydroxylating beta subunit K16303 - 1.14.12.25 0.00000000000000000000000000000000000000000000009768 174.0
HFD2_k127_5272467_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454,K02652 - - 1.609e-234 760.0
HFD2_k127_5272467_1 type II secretion system protein K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005251 496.0
HFD2_k127_5272467_2 Type II and III secretion system protein K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 456.0
HFD2_k127_5272467_3 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003993 416.0
HFD2_k127_5272467_4 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 385.0
HFD2_k127_5272467_5 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000003081 198.0
HFD2_k127_5272467_6 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000667 133.0
HFD2_k127_5279316_0 Cysteine synthase A K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 422.0
HFD2_k127_5279316_1 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004533 298.0
HFD2_k127_5279316_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000001009 205.0
HFD2_k127_5279316_3 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000005833 127.0
HFD2_k127_5279316_4 - - - - 0.0000000000000000000000000211 118.0
HFD2_k127_5279316_5 Histidine kinase - - - 0.00000000000000000000003127 111.0
HFD2_k127_5279316_6 EF-hand domain pair - - - 0.0004084 48.0
HFD2_k127_5317027_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.0 1092.0
HFD2_k127_5317027_1 Belongs to the TPP enzyme family K01577 - 4.1.1.8 7.68e-309 954.0
HFD2_k127_5317027_10 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000001476 146.0
HFD2_k127_5317027_2 Tripartite tricarboxylate transporter TctA family K07793 - - 2.716e-242 760.0
HFD2_k127_5317027_3 CoA-transferase family III K07749,K14471,K14472 - 2.8.3.16,2.8.3.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005684 598.0
HFD2_k127_5317027_4 PFAM formyl transferase domain protein K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007252 430.0
HFD2_k127_5317027_5 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007053 349.0
HFD2_k127_5317027_6 (FHA) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 317.0
HFD2_k127_5317027_7 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003412 260.0
HFD2_k127_5317027_8 CHASE2 K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000001125 164.0
HFD2_k127_5317027_9 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000000000000000000000000009488 156.0
HFD2_k127_5329818_0 Methionine synthase K00549 - 2.1.1.14 9.729e-201 634.0
HFD2_k127_5329818_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01857 - 5.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 573.0
HFD2_k127_5329818_2 Glucose inhibited division protein A - - - 0.0000000000000000000000000000000000000000000007181 167.0
HFD2_k127_5349363_0 mandelate racemase muconate lactonizing K01856 - 5.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 548.0
HFD2_k127_5349363_1 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006322 412.0
HFD2_k127_5349363_10 Periplasmic binding protein K01999 - - 0.0000000000000000000000000000000000007648 142.0
HFD2_k127_5349363_11 Cupin domain - - - 0.000000000000000000000000000000000001015 156.0
HFD2_k127_5349363_12 ABC transporter K01995 - - 0.00000000000000000000000000000000001564 154.0
HFD2_k127_5349363_13 Voltage-dependent anion channel K03304 - - 0.0000000000000000000000000000000003456 151.0
HFD2_k127_5349363_2 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 413.0
HFD2_k127_5349363_3 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009971 398.0
HFD2_k127_5349363_4 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000082 331.0
HFD2_k127_5349363_5 PFAM intradiol ring-cleavage dioxygenase K04098 - 1.13.11.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004756 306.0
HFD2_k127_5349363_6 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003185 266.0
HFD2_k127_5349363_7 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004545 261.0
HFD2_k127_5349363_8 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004345 254.0
HFD2_k127_5349363_9 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000001996 210.0
HFD2_k127_5351704_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 601.0
HFD2_k127_5351704_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004028 434.0
HFD2_k127_5351704_10 metal-binding, possibly nucleic acid-binding protein K07040 - - 0.000000000000000000000000009858 116.0
HFD2_k127_5351704_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007894 424.0
HFD2_k127_5351704_3 signal peptide peptidase K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003888 401.0
HFD2_k127_5351704_4 malonyl CoA-acyl carrier protein transacylase K00645,K15355 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 383.0
HFD2_k127_5351704_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 330.0
HFD2_k127_5351704_6 Uroporphyrin-iii c tetrapyrrole (Corrin porphyrin) methyltransferase K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000000000006136 246.0
HFD2_k127_5351704_7 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000001134 210.0
HFD2_k127_5351704_8 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000000000000003485 136.0
HFD2_k127_5351704_9 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000000000000006813 113.0
HFD2_k127_5385955_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1200.0
HFD2_k127_5385955_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006408 331.0
HFD2_k127_5385955_10 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000000004451 180.0
HFD2_k127_5385955_11 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K13053,K14160 - - 0.0000000000000000000000000000000000000000000000002891 184.0
HFD2_k127_5385955_12 Large exoproteins involved in heme utilization or adhesion - - - 0.00000000000000000000000000000000000000002397 174.0
HFD2_k127_5385955_13 Serine/threonine phosphatases, family 2C, catalytic domain K11890 - - 0.00000000000000000000000000000000000005542 154.0
HFD2_k127_5385955_14 Forkhead associated domain K07169,K11913 - - 0.0000000000000000000000000000000001837 147.0
HFD2_k127_5385955_15 cheY-homologous receiver domain - - - 0.00000000000000000000000000003453 121.0
HFD2_k127_5385955_16 peptidyl-tyrosine sulfation - - - 0.00000000000000000000009216 104.0
HFD2_k127_5385955_2 type VI secretion protein K11891 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006073 287.0
HFD2_k127_5385955_3 adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002361 275.0
HFD2_k127_5385955_4 Type VI secretion system protein DotU K11892 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002149 278.0
HFD2_k127_5385955_5 COG2202 FOG PAS PAC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004262 283.0
HFD2_k127_5385955_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K10715 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000008316 271.0
HFD2_k127_5385955_7 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000002343 240.0
HFD2_k127_5385955_8 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.000000000000000000000000000000000000000000000000000000000000003135 231.0
HFD2_k127_5385955_9 type VI secretion protein K11891 - - 0.0000000000000000000000000000000000000000000000000001199 199.0
HFD2_k127_5414982_0 formate-tetrahydrofolate ligase activity K01938 - 6.3.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 302.0
HFD2_k127_5414982_1 membrane protein, terc - - - 0.0000000000000000000000000000000000000000000000000000000000000000001067 238.0
HFD2_k127_5414982_2 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000001766 180.0
HFD2_k127_5423751_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K03520,K04108 - 1.2.5.3,1.3.7.9 1.766e-286 905.0
HFD2_k127_5423751_1 PFAM AMP-dependent synthetase and ligase K04116 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000533 541.0
HFD2_k127_5423751_10 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002803 278.0
HFD2_k127_5423751_11 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003406 274.0
HFD2_k127_5423751_12 [2Fe-2S] binding domain K04107 - 1.3.7.9 0.00000000000000000000000000000000000000000000000000000000000000004646 226.0
HFD2_k127_5423751_13 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000004697 186.0
HFD2_k127_5423751_14 Glyoxalase-like domain K01759,K08234 - 4.4.1.5 0.0000000000000000000000000000001483 127.0
HFD2_k127_5423751_15 Methylmuconolactone methyl-isomerase - - - 0.0000000000000000000003848 107.0
HFD2_k127_5423751_16 Pfam Hemerythrin HHE - - - 0.00000000001216 71.0
HFD2_k127_5423751_2 COG1960 Acyl-CoA dehydrogenases K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008015 467.0
HFD2_k127_5423751_3 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007841 460.0
HFD2_k127_5423751_4 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 448.0
HFD2_k127_5423751_5 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 373.0
HFD2_k127_5423751_6 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 351.0
HFD2_k127_5423751_7 KR domain K07535 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004811 338.0
HFD2_k127_5423751_8 CO dehydrogenase flavoprotein C-terminal domain K04109 - 1.3.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005833 312.0
HFD2_k127_5423751_9 abc transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 308.0
HFD2_k127_5431611_0 GXGXG motif K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 2349.0
HFD2_k127_5431611_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0 1253.0
HFD2_k127_5431611_10 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 393.0
HFD2_k127_5431611_11 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007716 360.0
HFD2_k127_5431611_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 329.0
HFD2_k127_5431611_13 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 297.0
HFD2_k127_5431611_14 epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008483 280.0
HFD2_k127_5431611_15 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002056 272.0
HFD2_k127_5431611_16 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001592 257.0
HFD2_k127_5431611_17 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001114 244.0
HFD2_k127_5431611_18 Pilus assembly protein, PilO K02664 - - 0.0000000000000000000000000000000000000000000000000000000000000008412 230.0
HFD2_k127_5431611_19 cytochrome - - - 0.00000000000000000000000000000000000000000000000000000000000001183 221.0
HFD2_k127_5431611_2 penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 4.502e-315 981.0
HFD2_k127_5431611_20 Shikimate kinase K00891 - 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000000002253 220.0
HFD2_k127_5431611_21 Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and the mispaired base. The complementary strand guanine functions in substrate recognition. Required for DNA damage lesion repair in stationary-phase cells K03649 - 3.2.2.28 0.000000000000000000000000000000000000000000000000000000008135 205.0
HFD2_k127_5431611_22 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000000000000000001092 199.0
HFD2_k127_5431611_23 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000002526 211.0
HFD2_k127_5431611_24 fimbrial biogenesis protein PilN K02663 - - 0.00000000000000000000000000000000000000000000000000002606 204.0
HFD2_k127_5431611_25 Protein of unknown function (DUF2891) - - - 0.000000000000000000000000000000000000000000001369 171.0
HFD2_k127_5431611_26 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000001246 175.0
HFD2_k127_5431611_27 protein involved in tolerance to divalent cations K03926 - - 0.000000000000000000000000000000000000006386 148.0
HFD2_k127_5431611_28 pilus assembly protein PilP K02665 - - 0.0000000000000000000000000000000000000996 158.0
HFD2_k127_5431611_29 Protein of unknown function (DUF2891) - - - 0.00000000000000000000000000000000003241 137.0
HFD2_k127_5431611_3 glutamate synthase K00266 - 1.4.1.13,1.4.1.14 8.233e-242 754.0
HFD2_k127_5431611_30 Belongs to the frataxin K06202 - - 0.0000000000000000000000000000000003669 133.0
HFD2_k127_5431611_31 PFAM Cytochrome C - - - 0.000000000000000000001499 105.0
HFD2_k127_5431611_32 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000003226 75.0
HFD2_k127_5431611_4 type II and III secretion system protein K02666 - - 8.728e-239 764.0
HFD2_k127_5431611_5 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 615.0
HFD2_k127_5431611_6 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 501.0
HFD2_k127_5431611_7 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 498.0
HFD2_k127_5431611_8 Type IV pilus assembly protein PilM K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004228 477.0
HFD2_k127_5431611_9 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006762 427.0
HFD2_k127_5460224_0 Histidine kinase K02487,K06596 - - 1.058e-301 989.0
HFD2_k127_5460224_1 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01907 - 6.2.1.16 2.785e-291 912.0
HFD2_k127_5460224_10 Oxidoreductase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 617.0
HFD2_k127_5460224_11 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 526.0
HFD2_k127_5460224_12 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 516.0
HFD2_k127_5460224_13 DAHP synthetase I family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008408 452.0
HFD2_k127_5460224_14 PFAM Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 448.0
HFD2_k127_5460224_15 Electron transfer flavoprotein K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 444.0
HFD2_k127_5460224_16 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin K10674 - 1.14.11.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 438.0
HFD2_k127_5460224_17 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000975 438.0
HFD2_k127_5460224_18 MscS Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 444.0
HFD2_k127_5460224_19 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 408.0
HFD2_k127_5460224_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.697e-288 892.0
HFD2_k127_5460224_20 Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009965 393.0
HFD2_k127_5460224_21 Receptor family ligand binding region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 401.0
HFD2_k127_5460224_22 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003716 380.0
HFD2_k127_5460224_23 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 374.0
HFD2_k127_5460224_24 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002493 368.0
HFD2_k127_5460224_25 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 339.0
HFD2_k127_5460224_26 citrate synthase K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 306.0
HFD2_k127_5460224_27 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003923 261.0
HFD2_k127_5460224_28 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000005477 250.0
HFD2_k127_5460224_29 PFAM response regulator receiver K02657 - - 0.0000000000000000000000000000000000000000000000000000000008098 204.0
HFD2_k127_5460224_3 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 1.575e-285 896.0
HFD2_k127_5460224_30 cheY-homologous receiver domain K02658 - - 0.0000000000000000000000000000000000000000000000000000235 191.0
HFD2_k127_5460224_31 Cupin 2, conserved barrel - - - 0.00000000000000000000000000000000000000000000000000003018 200.0
HFD2_k127_5460224_32 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000000000003278 164.0
HFD2_k127_5460224_33 Protein of unknown function (DUF962) - - - 0.000000000000000000000000000000000000005703 152.0
HFD2_k127_5460224_34 Chemotaxis signal transduction protein K02659 - - 0.00000000000000000000000000000000000008012 153.0
HFD2_k127_5460224_35 Thioesterase superfamily K07107 - - 0.00000000000000000000000000000002142 145.0
HFD2_k127_5460224_36 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.00000000000000000000000001245 125.0
HFD2_k127_5460224_37 [2Fe-2S] binding domain - - - 0.0000000000000001268 79.0
HFD2_k127_5460224_38 ABC transporter, ATP-binding protein K01996 - - 0.00000003861 56.0
HFD2_k127_5460224_4 electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 6.716e-248 783.0
HFD2_k127_5460224_5 Acyl-CoA dehydrogenase N terminal K20035 - - 2.671e-240 771.0
HFD2_k127_5460224_6 PFAM CoA-binding domain protein - - - 6.453e-225 718.0
HFD2_k127_5460224_7 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 1.067e-211 664.0
HFD2_k127_5460224_8 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 3.401e-205 644.0
HFD2_k127_5460224_9 Methyl-accepting chemotaxis protein K02660 - - 1.215e-203 676.0
HFD2_k127_5466243_0 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 620.0
HFD2_k127_5466243_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 327.0
HFD2_k127_5466243_2 negative regulator of sigma E activity K03598 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005499 269.0
HFD2_k127_5466243_3 Anti sigma-E protein RseA, N-terminal domain K03597 - - 0.00000000000000000000000001802 115.0
HFD2_k127_5488613_0 Carbamoyltransferase K00612 - - 7.377e-270 840.0
HFD2_k127_5488613_1 transferase activity, transferring glycosyl groups K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000101 231.0
HFD2_k127_5488613_2 - - - - 0.000000000000000000000000000005956 130.0
HFD2_k127_5488613_3 - - - - 0.00000000000002166 73.0
HFD2_k127_5494646_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006229 475.0
HFD2_k127_5494646_1 Methyl-accepting chemotaxis sensory transducer with Pas Pac sensor K02660 - - 0.0000000000000000000000000000000000000000000000000008315 190.0
HFD2_k127_5494646_2 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000004734 63.0
HFD2_k127_5497044_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.0 1055.0
HFD2_k127_5497044_1 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003776 587.0
HFD2_k127_5497044_2 Ribosomal RNA adenine dimethylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005376 246.0
HFD2_k127_5497044_3 Thioesterase-like superfamily - - - 0.0000000000000000000182 97.0
HFD2_k127_5497044_5 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.000003874 59.0
HFD2_k127_5497044_6 4 iron, 4 sulfur cluster binding - - - 0.00006354 54.0
HFD2_k127_5509898_0 Sodium Bile acid symporter family K03325 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 520.0
HFD2_k127_5509898_1 Methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 479.0
HFD2_k127_5509898_10 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K03520 - 1.2.5.3 0.00000001195 59.0
HFD2_k127_5509898_2 Hypothetical methyltransferase K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 397.0
HFD2_k127_5509898_3 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004958 297.0
HFD2_k127_5509898_4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000007527 266.0
HFD2_k127_5509898_5 ArsC family K00537,K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000001886 210.0
HFD2_k127_5509898_6 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000001818 162.0
HFD2_k127_5509898_7 Regulatory protein ArsR K03892 - - 0.0000000000000000000000000000000000001717 149.0
HFD2_k127_5509898_8 - - - - 0.0000000000000000000000000000000011 136.0
HFD2_k127_5509898_9 Domain of unknown function (DUF4440) - - - 0.000000000000000003919 94.0
HFD2_k127_5511528_0 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003855 440.0
HFD2_k127_5511528_1 Pyrimidine 5''-nucleotidase K07025 - - 0.00000000000000000000000000000000000000000000000000000000000000000001125 239.0
HFD2_k127_5511528_2 Bacterial regulatory proteins, tetR family K05501 - - 0.00000000000000000000000000000000000000000000000001545 182.0
HFD2_k127_5530972_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 4.365e-210 692.0
HFD2_k127_5530972_1 NMT1-like family K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 364.0
HFD2_k127_5530972_2 Pfam Transposase IS66 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 328.0
HFD2_k127_5530972_3 PFAM FMN-binding domain protein - - - 0.000000000000000000000000000000000000000000000000007509 190.0
HFD2_k127_5530972_4 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000001988 164.0
HFD2_k127_5530972_5 - - - - 0.0000000000000000002983 93.0
HFD2_k127_5536081_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1206.0
HFD2_k127_5536081_1 PFAM AAA ATPase central domain protein K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 422.0
HFD2_k127_5536081_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000008623 221.0
HFD2_k127_5536081_3 Modulates RecA activity K03565 - - 0.00000000000000000000001395 105.0
HFD2_k127_5536081_4 - - - - 0.0000000000000000189 87.0
HFD2_k127_55427_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 1.523e-273 859.0
HFD2_k127_55427_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 422.0
HFD2_k127_55427_2 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 301.0
HFD2_k127_55427_3 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 301.0
HFD2_k127_55427_4 binds to the 23S rRNA K02939 - - 0.00000000000000000000000000000000000000000000000000000000008023 211.0
HFD2_k127_55427_5 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000000000000000000000000000000000000005229 209.0
HFD2_k127_55427_6 - - - - 0.00000000000000000000000000000000000000000005915 170.0
HFD2_k127_55427_7 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000000000000000185 137.0
HFD2_k127_55427_8 His Kinase A (phospho-acceptor) domain - - - 0.00000000000000000001838 102.0
HFD2_k127_5545318_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 0.0 1089.0
HFD2_k127_5545318_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 1.064e-199 638.0
HFD2_k127_5545318_2 Glutathione S-transferase K03599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 323.0
HFD2_k127_5545318_3 LPPG Fo 2-phospho-L-lactate transferase K11212 - 2.7.8.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005646 283.0
HFD2_k127_5545318_4 Cytochrome C1 family K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000036 277.0
HFD2_k127_5545318_5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000004384 244.0
HFD2_k127_5545318_6 PFAM EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000005504 206.0
HFD2_k127_5545318_7 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.00000000000000000000000000000000000000000000000005452 183.0
HFD2_k127_5545318_8 stringent starvation protein B K03600 - - 0.0000000000000000000000000000000000000003879 162.0
HFD2_k127_5545318_9 cold-shock protein K03704 - - 0.000000000000000000000000000003563 121.0
HFD2_k127_5571562_0 Belongs to the peptidase M16 family K07263 - - 9.729e-265 842.0
HFD2_k127_5571562_1 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 557.0
HFD2_k127_5571562_10 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.0000000000000000000000000000000000000002378 161.0
HFD2_k127_5571562_11 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000009169 147.0
HFD2_k127_5571562_12 Domain of unknown function (DUF4112) - - - 0.0000000000000000000000000000000000001781 149.0
HFD2_k127_5571562_14 nuclear chromosome segregation - - - 0.00000000000004919 81.0
HFD2_k127_5571562_15 - - - - 0.000000000000183 77.0
HFD2_k127_5571562_16 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000002724 61.0
HFD2_k127_5571562_17 Domain of unknown function (DUF4398) - - - 0.00000157 56.0
HFD2_k127_5571562_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004329 410.0
HFD2_k127_5571562_3 Redoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000001557 245.0
HFD2_k127_5571562_4 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000001912 225.0
HFD2_k127_5571562_5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000000000000000000000000000000000000000000000000729 221.0
HFD2_k127_5571562_6 mannitol 2-dehydrogenase activity K11690 - - 0.000000000000000000000000000000000000000000000000000007281 192.0
HFD2_k127_5571562_7 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000001389 194.0
HFD2_k127_5571562_8 response to abiotic stimulus K06867 - - 0.00000000000000000000000000000000000000000000000584 181.0
HFD2_k127_5571562_9 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000001223 171.0
HFD2_k127_5574423_0 AcrB/AcrD/AcrF family K03296,K18138 - - 3.96e-257 802.0
HFD2_k127_5574423_1 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009711 457.0
HFD2_k127_5574423_10 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000003094 182.0
HFD2_k127_5574423_11 - - - - 0.0005852 48.0
HFD2_k127_5574423_2 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002784 457.0
HFD2_k127_5574423_3 e1 component (alpha subunit) K00161 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 415.0
HFD2_k127_5574423_4 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003812 386.0
HFD2_k127_5574423_5 abc transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007112 342.0
HFD2_k127_5574423_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 339.0
HFD2_k127_5574423_7 Phosphoenolpyruvate phosphomutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008376 252.0
HFD2_k127_5574423_8 SelR domain K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000003525 237.0
HFD2_k127_5574423_9 - - - - 0.0000000000000000000000000000000000000000000000000000002729 206.0
HFD2_k127_5587493_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 597.0
HFD2_k127_5587493_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 346.0
HFD2_k127_5587493_2 Lipid A Biosynthesis K02517,K12974 - 2.3.1.241,2.3.1.242 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 342.0
HFD2_k127_5587493_3 Lipid A Biosynthesis K02517,K12974 - 2.3.1.241,2.3.1.242 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007161 283.0
HFD2_k127_5587493_4 PFAM oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001138 271.0
HFD2_k127_5587493_5 Protein of unknown function, DUF484 K09921 - - 0.0000000000000000000005859 108.0
HFD2_k127_5614397_0 Poly-beta-hydroxybutyrate K03821 - - 5.202e-242 763.0
HFD2_k127_5614397_1 Bifunctional enoyl-CoA hydratase phosphate acetyltransferase K00625 - 2.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004143 600.0
HFD2_k127_5614397_2 GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 491.0
HFD2_k127_5614397_3 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 395.0
HFD2_k127_5614397_4 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007645 381.0
HFD2_k127_5614397_5 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001664 253.0
HFD2_k127_5614397_6 PFAM ATP-binding region, ATPase domain protein - - - 0.000000000000000000000000000000000007877 149.0
HFD2_k127_5614397_7 cheY-homologous receiver domain K03413 - - 0.000000000000006875 79.0
HFD2_k127_5614397_8 cheY-homologous receiver domain - - - 0.0000000000004144 78.0
HFD2_k127_5658651_0 Glycosyltransferase family 28 C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 572.0
HFD2_k127_5658651_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 507.0
HFD2_k127_5658651_10 glycosyl transferase - - - 0.000000000000000000000002255 116.0
HFD2_k127_5658651_11 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) - - - 0.0000000000000000006304 94.0
HFD2_k127_5658651_12 PFAM thioesterase superfamily protein - - - 0.000000000000002926 90.0
HFD2_k127_5658651_13 Acyl-CoA dehydrogenase, middle domain - - - 0.0000000000002244 70.0
HFD2_k127_5658651_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007811 357.0
HFD2_k127_5658651_3 PFAM Alcohol dehydrogenase zinc-binding domain protein K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000823 346.0
HFD2_k127_5658651_4 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 331.0
HFD2_k127_5658651_5 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 324.0
HFD2_k127_5658651_6 COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase) K00046 - 1.1.1.69 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 316.0
HFD2_k127_5658651_7 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 314.0
HFD2_k127_5658651_8 Phosphoglycerate mutase family - - - 0.000000000000000000000000000000000000000000000000000007759 196.0
HFD2_k127_5658651_9 - - - - 0.0000000000000000000000000000000000000000000000003011 191.0
HFD2_k127_5687326_0 Heparinase II/III N-terminus - - - 1.185e-207 666.0
HFD2_k127_5687326_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 6.974e-201 635.0
HFD2_k127_5687326_2 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 473.0
HFD2_k127_5687326_3 - Amino acid transport and metabolism K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 429.0
HFD2_k127_5687326_4 ROK family K00845,K00886 - 2.7.1.2,2.7.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001559 281.0
HFD2_k127_5687326_5 Methyltransferase domain - - - 0.00000000008569 76.0
HFD2_k127_5687326_6 T COG0642 Signal transduction histidine kinase - - - 0.0000000008487 66.0
HFD2_k127_5687326_7 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000003528 56.0
HFD2_k127_5712208_0 Tripartite tricarboxylate transporter TctA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 611.0
HFD2_k127_5712208_1 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 596.0
HFD2_k127_5712208_10 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.0000004287 53.0
HFD2_k127_5712208_2 Enolase C-terminal domain-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 508.0
HFD2_k127_5712208_3 Dihydrodipicolinate synthetase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 494.0
HFD2_k127_5712208_4 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 397.0
HFD2_k127_5712208_5 PFAM ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 350.0
HFD2_k127_5712208_6 Xylose isomerase-like TIM barrel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008799 330.0
HFD2_k127_5712208_7 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000000000000000000000000007561 244.0
HFD2_k127_5712208_8 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.0000000000000000000000000000000000000000000000000006618 205.0
HFD2_k127_5712208_9 Protein of unknown function (DUF993) - - - 0.0000000001614 73.0
HFD2_k127_5715189_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 492.0
HFD2_k127_5715189_1 Formamidopyrimidine-DNA glycosylase N-terminal domain K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005429 378.0
HFD2_k127_5715189_2 Methylenetetrahydrofolate reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004675 366.0
HFD2_k127_5715189_3 DsrE/DsrF-like family K09004 - - 0.0000000000000000000000000000000000001366 146.0
HFD2_k127_578292_0 Secretin and TonB N terminus short domain K02453 - - 5.144e-194 629.0
HFD2_k127_578292_1 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 317.0
HFD2_k127_578292_10 - - - - 0.000000000000001497 80.0
HFD2_k127_578292_2 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000132 295.0
HFD2_k127_578292_3 WbqC-like protein family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000003269 196.0
HFD2_k127_578292_4 Pfam:N_methyl_2 K02456 - - 0.000000000000000000000000000000000000000000000001876 190.0
HFD2_k127_578292_5 Type II secretory pathway, pseudopilin - - - 0.000000000000000000000000000000000000000000002697 169.0
HFD2_k127_578292_6 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000000000000000000000000000000007198 183.0
HFD2_k127_578292_7 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000000000000157 135.0
HFD2_k127_578292_8 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000001945 126.0
HFD2_k127_578292_9 Response regulator receiver - - - 0.0000000000000000002633 101.0
HFD2_k127_5789556_0 FAD dependent oxidoreductase - - - 9.909e-202 638.0
HFD2_k127_5789556_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009744 582.0
HFD2_k127_5789556_10 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000000000000000000000000000000000000002322 237.0
HFD2_k127_5789556_11 CoA binding domain K09181 - - 0.0000000000000000000000000000000000000000000008835 171.0
HFD2_k127_5789556_12 Alpha/beta hydrolase family K07020 - - 0.0000000000000000000000000000000000004265 147.0
HFD2_k127_5789556_13 histidine kinase A domain protein - - - 0.00000000000000000000000000000000004771 143.0
HFD2_k127_5789556_14 - - - - 0.000000000000000000004727 94.0
HFD2_k127_5789556_15 - - - - 0.0000000000000001212 89.0
HFD2_k127_5789556_16 - - - - 0.00000001171 61.0
HFD2_k127_5789556_2 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007137 468.0
HFD2_k127_5789556_3 Polysaccharide pyruvyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 455.0
HFD2_k127_5789556_4 Peptidase dimerisation domain K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 376.0
HFD2_k127_5789556_5 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003437 380.0
HFD2_k127_5789556_6 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007629 366.0
HFD2_k127_5789556_7 Histidine kinase K02484,K07645 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009905 300.0
HFD2_k127_5789556_8 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 290.0
HFD2_k127_5789556_9 response regulator K02483,K07666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005071 278.0
HFD2_k127_586913_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 9.526e-261 818.0
HFD2_k127_586913_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.275e-210 664.0
HFD2_k127_586913_2 Rod shape-determining protein MreB K03569 - - 1.79e-201 630.0
HFD2_k127_586913_3 Isocitrate lyase K01637 - 4.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 548.0
HFD2_k127_586913_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007937 532.0
HFD2_k127_586913_5 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002871 491.0
HFD2_k127_586913_6 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007591 311.0
HFD2_k127_586913_7 Rod shape-determining protein MreD K03571 - - 0.0000000000000000000000000000000000005833 151.0
HFD2_k127_586913_8 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000004455 116.0
HFD2_k127_6004204_0 Belongs to the peptidase S1C family K04691,K04772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 480.0
HFD2_k127_6004204_1 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003757 464.0
HFD2_k127_6004204_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006014 386.0
HFD2_k127_6004204_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005578 344.0
HFD2_k127_6004204_4 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000003693 255.0
HFD2_k127_6004204_5 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000000000005296 210.0
HFD2_k127_6004204_6 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 - - 0.0000000000000000000000000000000000000000000000147 179.0
HFD2_k127_6004204_7 PFAM Phosphoribosyl-ATP pyrophosphohydrolase K01523 GO:0000105,GO:0003674,GO:0003824,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.6.1.31 0.00000000000000000000000000000001024 136.0
HFD2_k127_6004204_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.00000000000000000000000002979 111.0
HFD2_k127_6004204_9 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000000000000003721 106.0
HFD2_k127_6024268_0 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006093 506.0
HFD2_k127_6024268_1 III protein, CoA-transferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006266 466.0
HFD2_k127_6024268_10 Transmembrane secretion effector - - - 0.0000000001711 62.0
HFD2_k127_6024268_2 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007532 461.0
HFD2_k127_6024268_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 432.0
HFD2_k127_6024268_4 HlyD family K01993 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005678 305.0
HFD2_k127_6024268_5 Methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000007932 258.0
HFD2_k127_6024268_6 Phosphoribosyl transferase domain - - - 0.00000000000000000000000000000000000000000000000000000001658 207.0
HFD2_k127_6024268_7 Thioesterase-like superfamily - - - 0.000000000000000000000000000000005261 146.0
HFD2_k127_6024268_8 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000001899 126.0
HFD2_k127_6031947_0 Glucose sorbosone K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005925 520.0
HFD2_k127_6031947_1 4,5-dihydroxyphthalate decarboxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 440.0
HFD2_k127_6031947_2 Oxidoreductase family, C-terminal alpha/beta domain K18067 - 1.3.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009778 398.0
HFD2_k127_6031947_3 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006117 288.0
HFD2_k127_6031947_4 ABC transporter substrate-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003945 277.0
HFD2_k127_6031947_5 Uncharacterized protein family UPF0016 - - - 0.000000000000000000000000000000000000000000000000000000000007458 210.0
HFD2_k127_6031947_6 membrane K15977 - - 0.000000000000000000000000000000000000000000000001776 179.0
HFD2_k127_6031947_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000001498 162.0
HFD2_k127_6031947_8 Protein of unknown function (DUF2799) - - - 0.0000000000000000000000000000283 127.0
HFD2_k127_6061266_0 Fumarate hydratase (Fumerase) K01677,K03779 - 4.2.1.2,4.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 443.0
HFD2_k127_6061266_1 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 346.0
HFD2_k127_6061266_2 Fumarase C-terminus K01678,K03780 - 4.2.1.2,4.2.1.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 316.0
HFD2_k127_6061266_3 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003917 256.0
HFD2_k127_6061266_4 Chalcone isomerase-like - - - 0.000000000000000000000000000000000000000000000000007205 194.0
HFD2_k127_6061266_5 Chalcone isomerase-like - - - 0.0000000000000000000000000000000000000009025 155.0
HFD2_k127_6061266_6 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00245 - 1.3.5.4 0.0000000000000000000000000000000002599 132.0
HFD2_k127_6061266_7 Succinate dehydrogenase/Fumarate reductase transmembrane subunit - - - 0.00000000000000000000000000000001463 132.0
HFD2_k127_6061266_8 Succinate dehydrogenase/Fumarate reductase transmembrane subunit - - - 0.0000000000000000000000000003741 122.0
HFD2_k127_608387_0 COG1271 Cytochrome bd-type quinol oxidase, subunit 1 K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 555.0
HFD2_k127_608387_1 AMP-binding enzyme C-terminal domain K04116 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004958 390.0
HFD2_k127_608387_2 cytochrome d ubiquinol oxidase, subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009492 370.0
HFD2_k127_608387_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 303.0
HFD2_k127_608387_4 Ser Thr phosphatase family protein K07098 - - 0.000000000000000000000000000000000000000000000000000000000000000000009471 246.0
HFD2_k127_608387_5 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000000000000006592 190.0
HFD2_k127_608387_6 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.00000000000000000000000000000000000000000000000002086 188.0
HFD2_k127_608387_7 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000003529 66.0
HFD2_k127_611523_0 TIGRFAM TRAP transporter, DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 598.0
HFD2_k127_611523_1 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 456.0
HFD2_k127_611523_2 Shikimate dehydrogenase substrate binding domain K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000002601 216.0
HFD2_k127_611523_3 - - - - 0.00000000000000000000000000000000000000000000000000000000001568 214.0
HFD2_k127_611523_4 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000003188 200.0
HFD2_k127_611523_5 Bacterial regulatory proteins, tetR family K09017 - - 0.0000000000000000000000000000000000000000000000000167 187.0
HFD2_k127_611523_6 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 0.000000001024 60.0
HFD2_k127_6149517_0 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 454.0
HFD2_k127_6149517_1 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006242 338.0
HFD2_k127_6149517_2 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000000000000000000000000001312 199.0
HFD2_k127_6149517_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000000000006593 190.0
HFD2_k127_6208842_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 607.0
HFD2_k127_6208842_1 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005698 553.0
HFD2_k127_6208842_2 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001227 274.0
HFD2_k127_6208842_3 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003426 259.0
HFD2_k127_6237854_0 Formate dehydrogenase, alpha subunit K00123,K22015 - 1.17.1.9,1.17.99.7 4.329e-250 778.0
HFD2_k127_6237854_1 Formate--tetrahydrofolate ligase K01938 - 6.3.4.3 8.949e-218 680.0
HFD2_k127_6237854_2 Cytidylate kinase-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000216 227.0
HFD2_k127_6245704_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 3.667e-295 924.0
HFD2_k127_6245704_1 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 3.328e-268 841.0
HFD2_k127_6245704_10 Peptidogalycan biosysnthesis/recognition K09919 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 415.0
HFD2_k127_6245704_11 Tripartite ATP-independent periplasmic - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 332.0
HFD2_k127_6245704_12 PFAM Short-chain dehydrogenase reductase SDR K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006939 336.0
HFD2_k127_6245704_13 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001309 281.0
HFD2_k127_6245704_14 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008051 280.0
HFD2_k127_6245704_15 Transcriptional regulator crp fnr family K10914 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003506 264.0
HFD2_k127_6245704_16 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000001307 252.0
HFD2_k127_6245704_17 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.000000000000000000000000000000000000000000000000000000000000008761 221.0
HFD2_k127_6245704_18 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000006656 201.0
HFD2_k127_6245704_19 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K21345 - 2.7.7.70 0.000000000000000000000000000000000000000000000000000007249 208.0
HFD2_k127_6245704_2 radical SAM domain protein K22318 - - 1.172e-236 745.0
HFD2_k127_6245704_20 periplasmic or secreted lipoprotein - - - 0.000000000000000000000000000000000000000000000000001752 202.0
HFD2_k127_6245704_21 Protein of unknown function (DUF3025) - - - 0.0000000000000000000000000000000000000000000004356 186.0
HFD2_k127_6245704_22 Small MutS-related domain - - - 0.00000000000000000000000000000000000000000004393 168.0
HFD2_k127_6245704_23 HIRAN - - - 0.000000000000000000000000000005073 124.0
HFD2_k127_6245704_24 - - - - 0.00000000000000000000000000002281 128.0
HFD2_k127_6245704_25 - - - - 0.000000000000000001448 92.0
HFD2_k127_6245704_26 Diguanylate cyclase - - - 0.0000000003601 67.0
HFD2_k127_6245704_3 DNA replication, recombination, and repair K07478 - - 3.146e-194 617.0
HFD2_k127_6245704_4 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 525.0
HFD2_k127_6245704_5 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007869 524.0
HFD2_k127_6245704_6 DEAD DEAH box helicase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005638 505.0
HFD2_k127_6245704_7 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 494.0
HFD2_k127_6245704_8 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 499.0
HFD2_k127_6245704_9 abc transporter K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 463.0
HFD2_k127_6300523_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 6.913e-209 656.0
HFD2_k127_6300523_1 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006577 490.0
HFD2_k127_6300523_2 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 392.0
HFD2_k127_6300523_3 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000599 400.0
HFD2_k127_6300523_4 Bacterial transcriptional repressor C-terminal - - - 0.0000000000000000000000000000000000000000000001061 174.0
HFD2_k127_6300523_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000312 151.0
HFD2_k127_6300523_6 protein conserved in bacteria K09937 - - 0.000000000000000001448 86.0
HFD2_k127_6318035_0 Adenylate and Guanylate cyclase catalytic domain - - - 5.992e-255 824.0
HFD2_k127_6318035_1 Thiamine pyrophosphate enzyme, central domain - - - 3.224e-214 696.0
HFD2_k127_6318035_10 NADPH-dependent FMN reductase K19784 - - 0.0000000000000000000000000000000000000000000000000463 186.0
HFD2_k127_6318035_11 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000001219 177.0
HFD2_k127_6318035_12 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity - - - 0.000000000000005172 77.0
HFD2_k127_6318035_13 EF-hand domain pair - - - 0.00009115 53.0
HFD2_k127_6318035_2 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 509.0
HFD2_k127_6318035_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 469.0
HFD2_k127_6318035_4 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 392.0
HFD2_k127_6318035_5 Chromate resistance exported protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002133 281.0
HFD2_k127_6318035_6 Pyruvate phosphate dikinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006439 266.0
HFD2_k127_6318035_7 Class II Aldolase and Adducin N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006173 264.0
HFD2_k127_6318035_8 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000001939 232.0
HFD2_k127_6318035_9 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000003747 231.0
HFD2_k127_6369509_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 4.496e-275 849.0
HFD2_k127_6369509_1 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.000000000000005817 80.0
HFD2_k127_6374125_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 2.47e-253 786.0
HFD2_k127_6374125_1 CHASE2 K01768 - 4.6.1.1 1.438e-212 691.0
HFD2_k127_6374125_2 methylenetetrahydrofolate reductase (NAD(P)H) activity K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 294.0
HFD2_k127_6374125_3 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 289.0
HFD2_k127_6374125_4 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000003936 279.0
HFD2_k127_6374125_5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003573 254.0
HFD2_k127_6374125_6 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.00000000000000000000000000000000000000000000006155 171.0
HFD2_k127_6374125_7 Bacterial SH3 domain - - - 0.000000000000000000000000000989 118.0
HFD2_k127_6374125_8 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000000000284 70.0
HFD2_k127_6415484_0 Competence protein ComEC Rec2 K02238 - - 6.836e-210 676.0
HFD2_k127_6415484_1 Protein of unknown function (DUF1538) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 591.0
HFD2_k127_6415484_2 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 352.0
HFD2_k127_6415484_3 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 339.0
HFD2_k127_6415484_4 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 300.0
HFD2_k127_6415484_5 protein conserved in bacteria K09928 - - 0.0000000000000000000000000000000000000000000000000007867 189.0
HFD2_k127_6415484_6 Nitrogen regulatory protein P-II - - - 0.000000000000000000000000000000000001816 158.0
HFD2_k127_6415484_7 - - - - 0.00000000000000001501 87.0
HFD2_k127_6416377_0 ABC transporter - - - 3.678e-246 770.0
HFD2_k127_6416377_1 Patatin phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004821 431.0
HFD2_k127_6416377_10 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000000000002574 209.0
HFD2_k127_6416377_11 YCII-related domain - - - 0.000000000000000000000000000000000000000000000005698 175.0
HFD2_k127_6416377_12 KR domain - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - 0.00000000000000000000000000000000000000000000001063 181.0
HFD2_k127_6416377_13 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000001509 80.0
HFD2_k127_6416377_2 Enoyl-(Acyl carrier protein) reductase K00019 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 359.0
HFD2_k127_6416377_3 Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 338.0
HFD2_k127_6416377_4 Methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003559 327.0
HFD2_k127_6416377_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 294.0
HFD2_k127_6416377_6 Domain of unknown function (DUF2437) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000559 278.0
HFD2_k127_6416377_7 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004458 256.0
HFD2_k127_6416377_8 TIGRFAM SagB-type dehydrogenase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002182 249.0
HFD2_k127_6416377_9 PFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000000000001755 226.0
HFD2_k127_6419675_0 Permease, YjgP YjgQ - - - 0.000000000000000000000000000000000000000000000000000000002577 223.0
HFD2_k127_6441387_0 elongation factor G K02355 - - 1.353e-287 897.0
HFD2_k127_6441387_1 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 451.0
HFD2_k127_6441387_2 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000001009 231.0
HFD2_k127_6441387_3 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000002056 135.0
HFD2_k127_6452826_0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 1.62e-245 760.0
HFD2_k127_6452826_1 Amidohydrolase K03392,K10220 - 4.1.1.45,4.2.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 601.0
HFD2_k127_6452826_10 nitrate reductase molybdenum cofactor assembly chaperone K00373 - - 0.00000000000000000000007094 100.0
HFD2_k127_6452826_11 SPW repeat - - - 0.0000000000000000001182 96.0
HFD2_k127_6452826_12 (Lipo)protein - - - 0.00000003936 61.0
HFD2_k127_6452826_2 CoA-transferase family III K07544 - 2.8.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006281 486.0
HFD2_k127_6452826_3 alcohol dehydrogenase K00148 - 1.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 451.0
HFD2_k127_6452826_4 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 405.0
HFD2_k127_6452826_5 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006267 362.0
HFD2_k127_6452826_6 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008042 264.0
HFD2_k127_6452826_7 Aldolase/RraA K02553,K10218 - 4.1.3.17 0.0000000000000000000000000000000000000000000000000000000000000000004413 248.0
HFD2_k127_6452826_8 Bacterial extracellular solute-binding proteins, family 3 - - - 0.0000000000000000000000000000000000000000000000000000001183 206.0
HFD2_k127_6452826_9 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.000000000000000000000000000000000000000000000000002828 193.0
HFD2_k127_6511292_0 PFAM amidohydrolase 2 K03392 - 4.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004965 345.0
HFD2_k127_6511292_1 ATPases associated with a variety of cellular activities K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 293.0
HFD2_k127_6511292_2 ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000003807 242.0
HFD2_k127_6511292_3 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000005729 126.0
HFD2_k127_6513591_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 1.486e-261 830.0
HFD2_k127_6513591_1 Phosphoglucomutase K15778 - 5.4.2.2,5.4.2.8 3.014e-207 669.0
HFD2_k127_6513591_10 Low affinity iron permease - - - 0.000000000000000000000000000000000000000000002749 169.0
HFD2_k127_6513591_11 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000000000000000000000000000002967 165.0
HFD2_k127_6513591_12 SnoaL-like domain - - - 0.0000000000000000000000000000000134 144.0
HFD2_k127_6513591_13 Extracellular solute-binding protein K02027,K05813 - - 0.00000000000000000000000000000007316 144.0
HFD2_k127_6513591_14 PFAM Sporulation domain protein - - - 0.00000000000000000000000000000008135 141.0
HFD2_k127_6513591_15 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000001707 106.0
HFD2_k127_6513591_16 PFAM response regulator receiver K03413 - - 0.00000000000000000000006442 103.0
HFD2_k127_6513591_17 Domain of unknown function (DUF4124) - - - 0.0000000000000000000002404 112.0
HFD2_k127_6513591_18 Zinc-finger domain - - - 0.00000000000000000001688 98.0
HFD2_k127_6513591_19 PFAM PsiF repeat protein - - - 0.000000000000000005525 94.0
HFD2_k127_6513591_2 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 576.0
HFD2_k127_6513591_3 Protein of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 517.0
HFD2_k127_6513591_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 498.0
HFD2_k127_6513591_5 heptosyltransferase II K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 336.0
HFD2_k127_6513591_6 alpha/beta hydrolase fold K07019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 327.0
HFD2_k127_6513591_7 Glutathione peroxidase K00432 - 1.11.1.9 0.0000000000000000000000000000000000000000000000000000000000004616 216.0
HFD2_k127_6513591_8 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000006667 216.0
HFD2_k127_6513591_9 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.00000000000000000000000000000000000000000000000000000007635 205.0
HFD2_k127_6553177_0 PFAM AMP-dependent synthetase and ligase K20034 - 6.2.1.44 1.463e-260 811.0
HFD2_k127_6553177_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 1.228e-199 636.0
HFD2_k127_6553177_10 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000002505 222.0
HFD2_k127_6553177_11 N-terminal half of MaoC dehydratase - - - 0.00000000000000000000000000000000000000000000002545 177.0
HFD2_k127_6553177_2 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004705 567.0
HFD2_k127_6553177_3 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 482.0
HFD2_k127_6553177_4 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 460.0
HFD2_k127_6553177_5 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005565 430.0
HFD2_k127_6553177_6 GMC oxidoreductase K00108 - 1.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006423 372.0
HFD2_k127_6553177_7 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005126 329.0
HFD2_k127_6553177_8 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009899 327.0
HFD2_k127_6553177_9 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000165 243.0
HFD2_k127_6593307_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 5.731e-307 956.0
HFD2_k127_6593307_1 Tripartite tricarboxylate transporter TctA family - - - 2.294e-213 671.0
HFD2_k127_6593307_2 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 521.0
HFD2_k127_6593307_3 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005096 251.0
HFD2_k127_6593307_4 GDSL-like Lipase/Acylhydrolase family - - - 0.000000000000000000000000000000000000000000000000000000001805 207.0
HFD2_k127_6593307_5 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000000000000000000000000005194 150.0
HFD2_k127_6593307_6 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000001139 136.0
HFD2_k127_6593307_7 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000000000003061 116.0
HFD2_k127_6593307_8 Thioesterase superfamily - - - 0.0000000000000000000004222 96.0
HFD2_k127_6594442_0 4-alpha-glucanotransferase K00705,K06044 - 2.4.1.25,5.4.99.15 0.0 1247.0
HFD2_k127_6594442_1 SMART alpha amylase catalytic sub domain K05343 - 3.2.1.1,5.4.99.16 5.529e-200 640.0
HFD2_k127_6594442_2 Alpha amylase, catalytic domain K01236 - 3.2.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 641.0
HFD2_k127_6594442_3 Asparaginase K13051 - 3.4.19.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000009335 267.0
HFD2_k127_6594442_4 PFAM Conserved TM helix repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000048 261.0
HFD2_k127_6594442_5 Protein of unknown function (DUF3750) - - - 0.00000000000000000000000000000004779 129.0
HFD2_k127_6594442_7 SMART Extracellular solute-binding protein, family 3 K02030 - - 0.000007089 57.0
HFD2_k127_6603518_0 NADH flavin oxidoreductase NADH oxidase K09461 - 1.14.13.40 0.0 1030.0
HFD2_k127_6603518_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.018e-266 839.0
HFD2_k127_6603518_10 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000001851 180.0
HFD2_k127_6603518_11 ACT domain - - - 0.00000000000000000000000000000001495 136.0
HFD2_k127_6603518_12 - - - - 0.00000000005968 71.0
HFD2_k127_6603518_2 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 6.933e-230 728.0
HFD2_k127_6603518_3 Cobalamin-independent synthase, Catalytic domain K00549,K22363 - 2.1.1.14,4.4.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008755 545.0
HFD2_k127_6603518_4 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 504.0
HFD2_k127_6603518_5 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 431.0
HFD2_k127_6603518_6 Belongs to the DapA family K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 291.0
HFD2_k127_6603518_7 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000003692 228.0
HFD2_k127_6603518_8 PFAM regulatory protein, MarR - - - 0.000000000000000000000000000000000000000000000000002549 186.0
HFD2_k127_6603518_9 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000001523 192.0
HFD2_k127_6635990_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004933 565.0
HFD2_k127_6635990_1 FAD binding domain K00481 - 1.14.13.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 568.0
HFD2_k127_6635990_10 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004658 294.0
HFD2_k127_6635990_11 Protein of unknown function (DUF1232) - - - 0.000000000000000000000000000001072 130.0
HFD2_k127_6635990_12 membrane - - - 0.000000000000000000000000005263 115.0
HFD2_k127_6635990_2 DNA helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005845 541.0
HFD2_k127_6635990_3 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 453.0
HFD2_k127_6635990_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 415.0
HFD2_k127_6635990_5 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000915 434.0
HFD2_k127_6635990_6 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003562 409.0
HFD2_k127_6635990_7 phosphate transport system permease K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 380.0
HFD2_k127_6635990_8 Transcriptional regulatory protein, C terminal K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 333.0
HFD2_k127_6635990_9 MgtC family K07507 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 321.0
HFD2_k127_6647527_0 Belongs to the TPP enzyme family K01576 - 4.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008999 600.0
HFD2_k127_6647527_1 PFAM Aminotransferase, class V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006182 467.0
HFD2_k127_6647527_2 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004928 413.0
HFD2_k127_6647527_3 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003604 389.0
HFD2_k127_6647527_4 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001487 285.0
HFD2_k127_6647527_5 Protein of unknown function (DUF3750) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000174 266.0
HFD2_k127_6647527_6 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000001195 239.0
HFD2_k127_6647527_7 Mechanosensitive ion channel - - - 0.000000000000000000000000006687 116.0
HFD2_k127_6671322_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 3.687e-257 798.0
HFD2_k127_6671322_1 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 554.0
HFD2_k127_6671322_2 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 531.0
HFD2_k127_6671322_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006585 437.0
HFD2_k127_6671322_4 hydrolases of the HAD superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001275 286.0
HFD2_k127_6671322_5 membrane transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000883 285.0
HFD2_k127_6671322_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000000000000000000000000000000000000002063 198.0
HFD2_k127_6671322_7 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.0000000000000000000000000000006457 123.0
HFD2_k127_6671322_8 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000006346 79.0
HFD2_k127_6671322_9 - - - - 0.000000000000003558 78.0
HFD2_k127_6684403_0 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 2.656e-228 717.0
HFD2_k127_6684403_1 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001894 361.0
HFD2_k127_6684403_2 major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002573 287.0
HFD2_k127_6684403_3 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000009647 182.0
HFD2_k127_6726810_0 binding domain K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1559.0
HFD2_k127_6726810_1 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738,K19515 - 1.2.7.5 3.121e-249 774.0
HFD2_k127_6726810_2 NADH dehydrogenase K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 397.0
HFD2_k127_6726810_3 PFAM methyl-viologen-reducing hydrogenase delta subunit K14127 - 1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001569 282.0
HFD2_k127_6726810_4 4 iron, 4 sulfur cluster binding K03522,K13795,K15511,K19516 - 1.14.13.208 0.000000000000000000000000000000000000000000000000000000000000000000000000000001533 275.0
HFD2_k127_6726810_5 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000001041 193.0
HFD2_k127_6751420_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K18361 - 1.17.5.1,3.1.2.25 0.0 1191.0
HFD2_k127_6751420_1 Belongs to the heme-copper respiratory oxidase family K04561 - 1.7.2.5 1.403e-200 633.0
HFD2_k127_6751420_10 Vitamin k epoxide reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000619 268.0
HFD2_k127_6751420_11 Cytochrome c K02305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004091 269.0
HFD2_k127_6751420_12 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001703 247.0
HFD2_k127_6751420_13 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000002505 211.0
HFD2_k127_6751420_14 - - - - 0.00000000000000000000000000000000000000000000000000000000455 205.0
HFD2_k127_6751420_15 transcriptional regulator, Rrf2 family K13771 - - 0.0000000000000000000000000000000000000000008043 160.0
HFD2_k127_6751420_16 Thioesterase - - - 0.000000000000000000000000000000000000000006728 157.0
HFD2_k127_6751420_17 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000002404 154.0
HFD2_k127_6751420_18 Thioesterase - - - 0.00000000000000000000000000000000000007917 149.0
HFD2_k127_6751420_19 - - - - 0.000000000000000000000000000000000002062 141.0
HFD2_k127_6751420_2 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 7.793e-199 629.0
HFD2_k127_6751420_20 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000005289 143.0
HFD2_k127_6751420_21 DMSO reductase anchor subunit (DmsC) K18363 - - 0.00000000000000000000000000000000001633 151.0
HFD2_k127_6751420_22 transcriptional regulator - - - 0.0000000000000000000000000000000005077 141.0
HFD2_k127_6751420_23 Ferredoxin K05337 - - 0.0000000000000000000000000000000009149 133.0
HFD2_k127_6751420_24 Uncharacterized conserved protein (DUF2249) K07322 - - 0.000000000000000000000000000001396 126.0
HFD2_k127_6751420_25 Benzoyl-CoA reductase subunit K04115 - 1.3.7.8 0.00000000000000000000000000002133 119.0
HFD2_k127_6751420_26 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000002257 122.0
HFD2_k127_6751420_27 Benzoyl-CoA reductase subunit K04115 - 1.3.7.8 0.0000000000000000000000000001183 115.0
HFD2_k127_6751420_28 Pfam:DUF59 - - - 0.000000000000000000000000001316 114.0
HFD2_k127_6751420_29 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000003528 115.0
HFD2_k127_6751420_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005937 589.0
HFD2_k127_6751420_30 Universal stress protein family - - - 0.00000000000000000000000005158 115.0
HFD2_k127_6751420_31 Phosphate starvation-inducible protein, PSIF - - - 0.000000000000000000007216 100.0
HFD2_k127_6751420_32 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000007594 107.0
HFD2_k127_6751420_33 Hemerythrin HHE cation binding domain - - - 0.0000000000000000007378 94.0
HFD2_k127_6751420_34 Mercury scavenger that specifically binds to one mercury ion and which passes it to the mercuric reductase (MerA) via the MerT protein K08364 - - 0.0000000000000001471 81.0
HFD2_k127_6751420_37 DGC domain protein - - - 0.00004955 49.0
HFD2_k127_6751420_4 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 507.0
HFD2_k127_6751420_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 376.0
HFD2_k127_6751420_6 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 372.0
HFD2_k127_6751420_7 COG0437 Fe-S-cluster-containing hydrogenase components 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 329.0
HFD2_k127_6751420_8 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008124 279.0
HFD2_k127_6751420_9 Hemerythrin HHE cation binding domain K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002881 287.0
HFD2_k127_6755416_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 7.933e-235 750.0
HFD2_k127_6755416_1 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005701 370.0
HFD2_k127_6755416_2 luxR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002407 255.0
HFD2_k127_6755416_3 Histidine kinase K07675 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000001519 201.0
HFD2_k127_6755416_4 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000001391 169.0
HFD2_k127_6755416_5 TPR repeat - - - 0.000000000000000000000000008504 114.0
HFD2_k127_6755416_6 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 0.000000000000009594 83.0
HFD2_k127_6755416_7 helix_turn_helix, Lux Regulon - - - 0.00001046 53.0
HFD2_k127_6918564_0 Orn/Lys/Arg decarboxylase, C-terminal domain K01583 - 4.1.1.19 0.0 1079.0
HFD2_k127_6918564_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.009e-284 892.0
HFD2_k127_6918564_10 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 406.0
HFD2_k127_6918564_11 Polyprenyl synthetase K00795 - 2.5.1.1,2.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 379.0
HFD2_k127_6918564_12 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 349.0
HFD2_k127_6918564_13 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 345.0
HFD2_k127_6918564_14 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 315.0
HFD2_k127_6918564_15 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 321.0
HFD2_k127_6918564_16 PFAM Transposase IS200 like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004354 299.0
HFD2_k127_6918564_17 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006297 302.0
HFD2_k127_6918564_18 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 298.0
HFD2_k127_6918564_19 Short-chain dehydrogenase reductase sdr - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 316.0
HFD2_k127_6918564_2 Belongs to the argininosuccinate synthase family. Type 2 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 7.704e-240 746.0
HFD2_k127_6918564_20 PFAM SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001755 260.0
HFD2_k127_6918564_21 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000004211 256.0
HFD2_k127_6918564_22 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000001276 251.0
HFD2_k127_6918564_23 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000002288 236.0
HFD2_k127_6918564_24 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.00000000000000000000000000000000000000000000000000000000000001124 220.0
HFD2_k127_6918564_25 Belongs to the UPF0234 family K09767 - - 0.000000000000000000000000000000000000000000000000000000000008345 222.0
HFD2_k127_6918564_26 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000005432 207.0
HFD2_k127_6918564_27 decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000000000001212 205.0
HFD2_k127_6918564_28 gag-polyprotein putative aspartyl protease K06985 - - 0.000000000000000000000000000000000000000000000000002337 189.0
HFD2_k127_6918564_29 Shikimate kinase K00851 - 2.7.1.12 0.0000000000000000000000000000000000000000000005007 171.0
HFD2_k127_6918564_3 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000091 627.0
HFD2_k127_6918564_30 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000000000000000000000000002068 166.0
HFD2_k127_6918564_31 Protein of unknown function (DUF3579) - - - 0.000000000000000000000000000005046 123.0
HFD2_k127_6918564_32 - - - - 0.0000000000000000000000008298 111.0
HFD2_k127_6918564_33 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000000007793 97.0
HFD2_k127_6918564_34 Protein of Unknown function (DUF2784) - - - 0.000000000000000001161 97.0
HFD2_k127_6918564_35 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000000000001401 82.0
HFD2_k127_6918564_36 helix_turn_helix, Lux Regulon - - - 0.00000001497 65.0
HFD2_k127_6918564_4 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004197 600.0
HFD2_k127_6918564_5 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007317 510.0
HFD2_k127_6918564_6 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 505.0
HFD2_k127_6918564_7 Domain of unknown function (DUF1730) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 497.0
HFD2_k127_6918564_8 rieske 2fe-2s K00499 - 1.14.15.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 492.0
HFD2_k127_6918564_9 N-Acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 466.0
HFD2_k127_6919841_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 1.187e-290 918.0
HFD2_k127_6919841_1 2Fe-2S -binding domain K07302 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000002627 226.0
HFD2_k127_6919841_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000002859 186.0
HFD2_k127_6921665_0 Thiamine pyrophosphate enzyme, central domain - - - 5.104e-294 920.0
HFD2_k127_6921665_1 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases K08319 - 1.1.1.411 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009156 307.0
HFD2_k127_6921665_2 ATPases associated with a variety of cellular activities K02010 - 3.6.3.30 0.0000000000000000000000000000000000000000000000000000000000000000004081 233.0
HFD2_k127_695277_0 FAD binding domain - - - 6.425e-229 720.0
HFD2_k127_695277_1 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007816 605.0
HFD2_k127_695277_10 Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331,K03940 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000797 237.0
HFD2_k127_695277_11 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.00000000000000000000000000000000000522 154.0
HFD2_k127_695277_12 preprotein translocase K03075 - - 0.0000000000000000000000001064 111.0
HFD2_k127_695277_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003854 582.0
HFD2_k127_695277_3 C4-dicarboxylate transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 507.0
HFD2_k127_695277_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002531 499.0
HFD2_k127_695277_5 dehydrogenase, E1 component K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 430.0
HFD2_k127_695277_6 PFAM Transketolase central region K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 422.0
HFD2_k127_695277_7 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 333.0
HFD2_k127_695277_8 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000346 310.0
HFD2_k127_695277_9 Cation efflux family K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 299.0
HFD2_k127_6954489_0 UDP binding domain K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000219 612.0
HFD2_k127_6954489_1 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 536.0
HFD2_k127_6954489_2 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 427.0
HFD2_k127_6954489_3 pfkB family carbohydrate kinase K03272,K21344 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003966 359.0
HFD2_k127_6954489_4 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 295.0
HFD2_k127_6954489_5 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.000000000000000000000000000000000000000000001135 167.0
HFD2_k127_6954489_6 Lipopolysaccharide assembly protein A domain K08992 - - 0.000000000000001906 79.0
HFD2_k127_6964230_0 Cysteine-rich domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 584.0
HFD2_k127_6964230_1 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005178 540.0
HFD2_k127_6964230_2 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002556 248.0
HFD2_k127_6964230_3 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 0.000000000000000000000000000000000000000000009094 171.0
HFD2_k127_6964230_4 Sortase family K07284 - 3.4.22.70 0.0000000000000000000000000000000000000000005429 182.0
HFD2_k127_6964230_5 ATP synthesis coupled electron transport K00123,K00336 - 1.17.1.9,1.6.5.3 0.0000000000000000000000000000002113 124.0
HFD2_k127_6964230_6 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000005009 109.0
HFD2_k127_6964230_7 - - - - 0.0000000000000002168 81.0
HFD2_k127_6967586_0 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 452.0
HFD2_k127_6967586_1 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 373.0
HFD2_k127_6967586_2 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 291.0
HFD2_k127_6967586_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000001632 259.0
HFD2_k127_6967586_4 D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000000000000000000000000001491 235.0
HFD2_k127_6967586_5 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000000000000000003094 190.0
HFD2_k127_6967586_6 Lactoylglutathione lyase K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000001325 183.0
HFD2_k127_6967586_7 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.0000000000000000006171 88.0
HFD2_k127_7043712_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 8.816e-246 770.0
HFD2_k127_7043712_1 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 543.0
HFD2_k127_7043712_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000153 199.0
HFD2_k127_7043712_3 transporter solute receptor, DctP family K11688 - - 0.0000000001012 73.0
HFD2_k127_7043712_4 Domain of unknown function (DUF4124) - - - 0.000001707 60.0
HFD2_k127_7043712_5 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component K11689 - - 0.0003865 49.0
HFD2_k127_7050866_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 1.453e-250 786.0
HFD2_k127_7050866_1 Domain of Unknown Function (DUF748) - - - 8.86e-238 777.0
HFD2_k127_7050866_10 Protein of unknown function (DUF3293) - - - 0.00000000000000002492 87.0
HFD2_k127_7050866_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K15509 - 1.1.1.308 5.748e-201 634.0
HFD2_k127_7050866_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046,K00065 - 1.1.1.127,1.1.1.69 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008005 273.0
HFD2_k127_7050866_4 MASE2 domain K18968 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000007838 192.0
HFD2_k127_7050866_5 Forkhead associated domain - - - 0.000000000000000000000000000000000000000000000000001565 194.0
HFD2_k127_7050866_6 3'-5' exonuclease - - - 0.00000000000000000000000000000000000000000000002491 176.0
HFD2_k127_7050866_7 Transglycosylase associated protein - - - 0.00000000000000000000000000000000007638 136.0
HFD2_k127_7050866_8 Belongs to the UPF0337 (CsbD) family - - - 0.0000000000000000000000312 115.0
HFD2_k127_7050866_9 - - - - 0.0000000000000000002592 102.0
HFD2_k127_7056774_0 Extracellular liganD-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 590.0
HFD2_k127_7056774_1 Aconitase family (aconitate hydratase) K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008704 565.0
HFD2_k127_7056774_10 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000402 209.0
HFD2_k127_7056774_11 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000008748 208.0
HFD2_k127_7056774_12 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000009264 202.0
HFD2_k127_7056774_13 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000001667 173.0
HFD2_k127_7056774_14 ABC-type branched-chain amino acid transport K01999 - - 0.0000000000000000000000000000000000001602 158.0
HFD2_k127_7056774_15 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000002464 153.0
HFD2_k127_7056774_16 SnoaL-like domain - - - 0.000000000000000000000000000000002436 134.0
HFD2_k127_7056774_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 437.0
HFD2_k127_7056774_3 Isocitrate lyase and phosphorylmutase K01841 - 5.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003901 383.0
HFD2_k127_7056774_4 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 384.0
HFD2_k127_7056774_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 376.0
HFD2_k127_7056774_6 MmgE/PrpD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 353.0
HFD2_k127_7056774_7 amino acid K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 325.0
HFD2_k127_7056774_8 amino acid K01995,K10822 - 3.6.3.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005836 327.0
HFD2_k127_7056774_9 [2Fe-2S] binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001439 238.0
HFD2_k127_7100787_0 AMP-binding enzyme C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 596.0
HFD2_k127_7100787_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 570.0
HFD2_k127_7100787_2 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003934 306.0
HFD2_k127_7100787_3 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000117 278.0
HFD2_k127_7100787_4 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.00000000000000000000000000000000000000000000000000000009949 197.0
HFD2_k127_7100787_5 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000001065 201.0
HFD2_k127_7100787_6 COGs COG2852 conserved - - - 0.0000000000000000000000000002526 126.0
HFD2_k127_7100787_7 diguanylate cyclase - - - 0.00000000000000002493 87.0
HFD2_k127_7100787_8 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00002022 54.0
HFD2_k127_7107267_0 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 5.532e-244 778.0
HFD2_k127_7107267_1 type II secretion system protein E K02454,K02652 - - 1.169e-235 766.0
HFD2_k127_7107267_10 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 558.0
HFD2_k127_7107267_11 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009124 537.0
HFD2_k127_7107267_12 glycolate oxidase subunit GlcD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 533.0
HFD2_k127_7107267_13 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 514.0
HFD2_k127_7107267_14 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 496.0
HFD2_k127_7107267_15 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 458.0
HFD2_k127_7107267_16 Carbon-nitrogen hydrolase K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 467.0
HFD2_k127_7107267_17 phosphate starvation-inducible protein PhoH K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009833 454.0
HFD2_k127_7107267_18 Transporter associated domain K06189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 394.0
HFD2_k127_7107267_19 ABC-type polar amino acid transport system, ATPase component K10004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 402.0
HFD2_k127_7107267_2 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K00156,K01576,K01652 - 1.2.5.1,2.2.1.6,4.1.1.7 8.531e-218 689.0
HFD2_k127_7107267_20 Membrane-bound lytic murein transglycosylase K08304 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 386.0
HFD2_k127_7107267_21 Zinc-binding dehydrogenase K12957,K13953,K19961 - 1.1.1.1,1.1.1.258 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 383.0
HFD2_k127_7107267_22 Bacterial periplasmic substrate-binding proteins K02030,K10001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005237 373.0
HFD2_k127_7107267_23 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 373.0
HFD2_k127_7107267_24 Aminotransferase class I and II K14155 - 4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003283 372.0
HFD2_k127_7107267_25 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 354.0
HFD2_k127_7107267_26 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000075 334.0
HFD2_k127_7107267_27 Carboxylesterase family K01066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008648 335.0
HFD2_k127_7107267_28 TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family K10002 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 328.0
HFD2_k127_7107267_29 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K03185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006821 332.0
HFD2_k127_7107267_3 Aspartate ammonia-lyase K01744 - 4.3.1.1 2.636e-213 686.0
HFD2_k127_7107267_30 ABC transporter permease K02029,K10003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 317.0
HFD2_k127_7107267_31 Belongs to the TrpC family K01609 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 316.0
HFD2_k127_7107267_32 Anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008269 291.0
HFD2_k127_7107267_33 Putative aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005414 291.0
HFD2_k127_7107267_34 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000403 273.0
HFD2_k127_7107267_35 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000413 280.0
HFD2_k127_7107267_36 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005963 265.0
HFD2_k127_7107267_37 Glutathione S-Transferase K00799 GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016740,GO:0016765,GO:0030611,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000007475 265.0
HFD2_k127_7107267_38 dehydratase K18290 - 4.2.1.56 0.00000000000000000000000000000000000000000000000000000000000000000000000008347 253.0
HFD2_k127_7107267_39 CoA-binding protein K06929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002756 241.0
HFD2_k127_7107267_4 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 9.238e-211 661.0
HFD2_k127_7107267_40 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000000000000000000268 231.0
HFD2_k127_7107267_41 regulator of disulfide bond formation K07397 - - 0.000000000000000000000000000000000000000000000000000000000000000000459 230.0
HFD2_k127_7107267_42 - - - - 0.000000000000000000000000000000000000000000000000000000000000001863 225.0
HFD2_k127_7107267_43 cyclic nucleotide binding K01420 - - 0.000000000000000000000000000000000000000000000000000000000006485 229.0
HFD2_k127_7107267_44 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000001012 211.0
HFD2_k127_7107267_45 Required for insertion of 4Fe-4S clusters K15724 - - 0.000000000000000000000000000000000000000000000000000000007657 201.0
HFD2_k127_7107267_46 protein affecting Mg2 Co2 transport K06195 - - 0.0000000000000000000000000000000000000000000000000000001415 196.0
HFD2_k127_7107267_47 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000000000000000000000009511 205.0
HFD2_k127_7107267_48 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000005345 185.0
HFD2_k127_7107267_49 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.000000000000000000000000000000000000000000003833 172.0
HFD2_k127_7107267_5 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 632.0
HFD2_k127_7107267_50 - - - - 0.000000000000000000000000000000000000000000004699 173.0
HFD2_k127_7107267_51 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000002358 164.0
HFD2_k127_7107267_52 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000000000000000000000000000000000000002763 167.0
HFD2_k127_7107267_53 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000001666 154.0
HFD2_k127_7107267_54 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000003107 136.0
HFD2_k127_7107267_55 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000002654 137.0
HFD2_k127_7107267_56 Uncharacterized protein family UPF0054 K07042 - - 0.0000000000000000000000000001822 121.0
HFD2_k127_7107267_57 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000002418 122.0
HFD2_k127_7107267_58 Alpha/beta hydrolase family - - - 0.000000000000000000001285 109.0
HFD2_k127_7107267_59 Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - 0.0000000000000007014 91.0
HFD2_k127_7107267_6 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000948 595.0
HFD2_k127_7107267_60 - - - - 0.0000000000889 67.0
HFD2_k127_7107267_7 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 601.0
HFD2_k127_7107267_8 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000456 587.0
HFD2_k127_7107267_9 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 567.0
HFD2_k127_7137670_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 3.743e-319 986.0
HFD2_k127_7137670_1 Putative Na+/H+ antiporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 525.0
HFD2_k127_7137670_10 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000001108 95.0
HFD2_k127_7137670_2 PFAM aminotransferase class I and II K00832 - 2.6.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004574 520.0
HFD2_k127_7137670_3 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 510.0
HFD2_k127_7137670_4 MASE1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007069 351.0
HFD2_k127_7137670_5 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 322.0
HFD2_k127_7137670_6 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000004931 215.0
HFD2_k127_7137670_7 Two component transcriptional regulator, LuxR family K13041 - - 0.0000000000000000000000000000000000000000000000000001207 198.0
HFD2_k127_7137670_8 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000000000000000000000000000000001215 203.0
HFD2_k127_7137670_9 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000435 201.0
HFD2_k127_7196002_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1844.0
HFD2_k127_7196002_1 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 1.668e-197 627.0
HFD2_k127_7215158_0 PFAM AMP-dependent synthetase and ligase K00666 - - 8.678e-289 910.0
HFD2_k127_7215158_1 Belongs to the UbiD family K03182 - 4.1.1.98 1.403e-215 678.0
HFD2_k127_7215158_10 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 298.0
HFD2_k127_7215158_11 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01040 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000383 283.0
HFD2_k127_7215158_12 Protein of unknown function (DUF2889) - - - 0.000000000000000000000000000000000000000000000000000000000000003797 222.0
HFD2_k127_7215158_13 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000001049 119.0
HFD2_k127_7215158_2 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 5.664e-213 672.0
HFD2_k127_7215158_3 Putative modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000308 568.0
HFD2_k127_7215158_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 569.0
HFD2_k127_7215158_5 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 579.0
HFD2_k127_7215158_6 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 498.0
HFD2_k127_7215158_7 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 435.0
HFD2_k127_7215158_8 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 346.0
HFD2_k127_7215158_9 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006102 331.0
HFD2_k127_7226891_0 Periplasmic binding protein K01999 - - 3.222e-201 634.0
HFD2_k127_7226891_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003798 520.0
HFD2_k127_7226891_2 AMP-binding enzyme K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 521.0
HFD2_k127_7226891_3 branched-chain amino acid K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008654 439.0
HFD2_k127_7226891_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 429.0
HFD2_k127_7226891_5 hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 384.0
HFD2_k127_7226891_6 2-hydroxychromene-2-carboxylate isomerase K14584 - 5.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000006059 254.0
HFD2_k127_7226891_7 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000002826 157.0
HFD2_k127_7230227_0 PrkA AAA domain K07180 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 449.0
HFD2_k127_7230227_1 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 426.0
HFD2_k127_7230227_2 MltA-interacting protein MipA K07274 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003127 362.0
HFD2_k127_7230227_3 KR domain K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 311.0
HFD2_k127_7230227_4 Bacterial extracellular solute-binding protein K22003 - 5.3.3.7 0.0000000000000000000000000000000000000000000004472 174.0
HFD2_k127_7230227_5 MAPEG family - - - 0.00000000000000000000000000000000000005806 151.0
HFD2_k127_7230227_6 - - - - 0.000000000009457 70.0
HFD2_k127_7237753_0 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008533 513.0
HFD2_k127_7237753_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 447.0
HFD2_k127_7237753_2 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002155 275.0
HFD2_k127_7237753_3 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007283 273.0
HFD2_k127_7237753_4 Protein of unknown function (DUF3501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000008325 239.0
HFD2_k127_7237753_5 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000000009869 180.0
HFD2_k127_7237753_6 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000000000000000002957 149.0
HFD2_k127_7237753_7 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000005655 129.0
HFD2_k127_7237753_8 CNP1-like family - - - 0.0000000000000000000000000001332 128.0
HFD2_k127_7237753_9 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.000000000000000000000000003401 113.0
HFD2_k127_7243267_0 Amylo-alpha-1,6-glucosidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002375 603.0
HFD2_k127_7243267_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003983 452.0
HFD2_k127_7243267_2 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007122 282.0
HFD2_k127_7243267_3 Histidine kinase - - - 0.0000000000000000000000000004516 119.0
HFD2_k127_7245280_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 0.0 1562.0
HFD2_k127_7245280_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.135e-258 812.0
HFD2_k127_7245280_10 Class II Aldolase and Adducin N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 302.0
HFD2_k127_7245280_11 Flavin containing amine oxidoreductase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.00000000000000000000000000000000000000000000000000000000000003006 244.0
HFD2_k127_7245280_12 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000000001278 200.0
HFD2_k127_7245280_13 Alpha beta hydrolase - - - 0.000000000000000000007423 92.0
HFD2_k127_7245280_2 Flavin containing amine oxidoreductase - - - 1.145e-217 706.0
HFD2_k127_7245280_3 PFAM extracellular solute-binding protein family 1 K05813 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 550.0
HFD2_k127_7245280_4 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003375 517.0
HFD2_k127_7245280_5 Glycine cleavage T-protein C-terminal barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 466.0
HFD2_k127_7245280_6 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K05816,K10111,K10112 - 3.6.3.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 433.0
HFD2_k127_7245280_7 PFAM binding-protein-dependent transport systems inner membrane component K05814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009153 415.0
HFD2_k127_7245280_8 probably responsible for the translocation of the substrate across the membrane K05815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008968 419.0
HFD2_k127_7245280_9 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 308.0
HFD2_k127_7260810_0 Poly(R)-hydroxyalkanoic acid synthase, class I K03821 - - 1.278e-197 631.0
HFD2_k127_7260810_1 Belongs to the thiolase family K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 602.0
HFD2_k127_7260810_2 epimerase dehydratase K22025 - 1.1.1.410 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 462.0
HFD2_k127_7260810_3 HELICc2 K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009572 392.0
HFD2_k127_7260810_4 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009618 357.0
HFD2_k127_7260810_5 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 345.0
HFD2_k127_7260810_6 Belongs to the short-chain dehydrogenases reductases (SDR) family K00023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 328.0
HFD2_k127_7260810_7 ZIP Zinc transporter K16267 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 313.0
HFD2_k127_7260810_8 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000006481 219.0
HFD2_k127_7260810_9 Acetoacetyl-CoA reductase K00023 - 1.1.1.36 0.000000004928 67.0
HFD2_k127_7296920_0 Pfam Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003013 451.0
HFD2_k127_7296920_1 PFAM glycosyl transferase group 1 K12995 - 2.4.1.348 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003902 452.0
HFD2_k127_7296920_2 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 448.0
HFD2_k127_7296920_3 N-terminal domain of (some) glycogen debranching enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003364 291.0
HFD2_k127_7296920_4 Methyltransferase type 11 K00570 - 2.1.1.17,2.1.1.71 0.0000000000000000000000000000000000000000000000000000000005349 208.0
HFD2_k127_7296920_5 Acid phosphatase homologues - - - 0.00000000000000000000000000000000000000000000002796 194.0
HFD2_k127_7296920_6 deoxyhypusine monooxygenase activity K01387 - 3.4.24.3 0.000000000000000000000000000000000000000003156 175.0
HFD2_k127_7296920_7 glyoxalase K08234 - - 0.000000000000000000000000000000000009363 157.0
HFD2_k127_7296920_8 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000001176 152.0
HFD2_k127_7296920_9 - - - - 0.0008605 49.0
HFD2_k127_7309411_0 efflux pump K18138,K18146 - - 4.816e-223 703.0
HFD2_k127_7309411_1 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 360.0
HFD2_k127_7309411_2 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003749 346.0
HFD2_k127_7309411_3 Predicted integral membrane protein (DUF2269) - - - 0.000004716 59.0
HFD2_k127_7312449_0 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000005961 252.0
HFD2_k127_7312449_1 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000001151 209.0
HFD2_k127_7318138_0 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 4.147e-237 741.0
HFD2_k127_7318138_1 Tripartite tricarboxylate transporter TctA family - - - 2.557e-218 691.0
HFD2_k127_7318138_10 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000000000000000003534 220.0
HFD2_k127_7318138_11 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000000000169 147.0
HFD2_k127_7318138_12 of the alpha beta superfamily - - - 0.0000000000000000000000000002046 118.0
HFD2_k127_7318138_13 OmpA-like transmembrane domain - - - 0.0000000000000000000002272 104.0
HFD2_k127_7318138_14 OmpA-like transmembrane domain - - - 0.0000000000000000000002596 105.0
HFD2_k127_7318138_15 OmpA-like transmembrane domain - - - 0.00000000000000002447 89.0
HFD2_k127_7318138_16 Fatty acid desaturase - - - 0.00000000000007136 80.0
HFD2_k127_7318138_17 Belongs to the ompA family K03286 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.0000001792 63.0
HFD2_k127_7318138_2 Bacterial protein of unknown function (DUF853) K06915 - - 1.49e-213 673.0
HFD2_k127_7318138_3 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 609.0
HFD2_k127_7318138_4 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 449.0
HFD2_k127_7318138_5 Short chain dehydrogenase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 366.0
HFD2_k127_7318138_6 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 361.0
HFD2_k127_7318138_7 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000009199 252.0
HFD2_k127_7318138_8 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000001012 237.0
HFD2_k127_7318138_9 [2Fe-2S] binding domain K00256,K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000009701 240.0
HFD2_k127_7325376_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 370.0
HFD2_k127_7325376_1 GDP-mannose 4,6 dehydratase K18981 - 1.1.1.203 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001554 283.0
HFD2_k127_7325376_2 FCD - - - 0.0000000000000000000000000000000000002077 145.0
HFD2_k127_7325376_3 metal-dependent hydrolase of the TIM-barrel fold - - - 0.000000009228 66.0
HFD2_k127_7335181_0 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 6.801e-219 692.0
HFD2_k127_7335181_1 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003667 599.0
HFD2_k127_7335181_10 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 315.0
HFD2_k127_7335181_11 KR domain K00076,K08081 - 1.1.1.159,1.1.1.206 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 310.0
HFD2_k127_7335181_12 mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 307.0
HFD2_k127_7335181_13 phosphate transport regulator K07220 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 284.0
HFD2_k127_7335181_14 Acyl-CoA dehydrogenase, middle domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001245 298.0
HFD2_k127_7335181_15 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001703 286.0
HFD2_k127_7335181_16 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005311 248.0
HFD2_k127_7335181_17 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000000000000000006406 209.0
HFD2_k127_7335181_18 Pfam Methyltransferase - - - 0.000000000000000000000000000000000000000001269 182.0
HFD2_k127_7335181_19 protein conserved in bacteria K09796 - - 0.00000000000000000000000000007966 134.0
HFD2_k127_7335181_2 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 561.0
HFD2_k127_7335181_20 Pfam:Pyridox_oxidase - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000006315 94.0
HFD2_k127_7335181_22 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000001201 76.0
HFD2_k127_7335181_23 - - - - 0.0000000006833 62.0
HFD2_k127_7335181_25 - - - - 0.0009318 51.0
HFD2_k127_7335181_3 Phosphate transporter K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009134 517.0
HFD2_k127_7335181_4 PFAM L-carnitine dehydratase bile acid-inducible protein F K01796 - 5.1.99.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 493.0
HFD2_k127_7335181_5 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 466.0
HFD2_k127_7335181_6 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006479 431.0
HFD2_k127_7335181_7 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01781,K20023 - 4.2.1.156,4.2.1.42,5.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 441.0
HFD2_k127_7335181_8 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005659 367.0
HFD2_k127_7335181_9 Periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 350.0
HFD2_k127_7367537_0 Xanthine dehydrogenase K03520 - 1.2.5.3 9.253e-223 706.0
HFD2_k127_7367537_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000001258 187.0
HFD2_k127_7370047_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 469.0
HFD2_k127_7370047_1 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 472.0
HFD2_k127_7370047_2 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 291.0
HFD2_k127_7370047_3 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000000000000000000000000000001115 236.0
HFD2_k127_7370047_4 lactate metabolic process K00113 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3 0.000000000000000000000000000000000000000000000000000000001915 220.0
HFD2_k127_7370047_5 lactate metabolic process - - - 0.0000000000000000000000277 114.0
HFD2_k127_7378673_0 Predicted membrane protein (DUF2339) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005552 484.0
HFD2_k127_7378673_1 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 455.0
HFD2_k127_7378673_2 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002857 273.0
HFD2_k127_7378673_3 PFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000002652 251.0
HFD2_k127_7378673_4 - - - - 0.000000000000000000000000001394 117.0
HFD2_k127_738102_0 Proton-conducting membrane transporter - - - 4.637e-284 887.0
HFD2_k127_738102_1 PFAM Cytochrome c oxidase, subunit I K02274 - 1.9.3.1 2.939e-264 824.0
HFD2_k127_738102_10 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000000000002117 122.0
HFD2_k127_738102_11 Proton-conducting membrane transporter K12141 - - 0.0000000000000000000000000001177 127.0
HFD2_k127_738102_12 - - - - 0.00000000000176 69.0
HFD2_k127_738102_13 Uncharacterized conserved protein (DUF2249) - - - 0.0000001757 62.0
HFD2_k127_738102_14 Cytochrome oxidase assembly protein K02259 - - 0.0000218 56.0
HFD2_k127_738102_2 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 452.0
HFD2_k127_738102_3 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 404.0
HFD2_k127_738102_4 COG4237 Hydrogenase 4 membrane component (E) K12140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004234 302.0
HFD2_k127_738102_5 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001512 307.0
HFD2_k127_738102_6 Cyclic nucleotide-monophosphate binding domain K21563 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004514 260.0
HFD2_k127_738102_7 cytochrome c oxidase (Subunit II) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001007 254.0
HFD2_k127_738102_8 Catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose K00523 - 1.17.1.1 0.0000000000000000000000000000000000000000000000000000000000000000001085 245.0
HFD2_k127_738102_9 PFAM electron transport protein SCO1 SenC K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000004783 241.0
HFD2_k127_7382819_0 UDP binding domain K02474 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 598.0
HFD2_k127_7382819_1 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008549 402.0
HFD2_k127_7382819_10 TIGRFAM peptidyl-prolyl cis-trans isomerase, EpsD family - - - 0.00000000000000000000000000000000000000002644 165.0
HFD2_k127_7382819_11 Bacterial sugar transferase K03606 - - 0.000000000000000006671 90.0
HFD2_k127_7382819_12 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus - - - 0.000001641 61.0
HFD2_k127_7382819_2 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009001 336.0
HFD2_k127_7382819_3 Chain length determinant protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 303.0
HFD2_k127_7382819_4 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007499 293.0
HFD2_k127_7382819_5 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000003134 244.0
HFD2_k127_7382819_6 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000000000000000000000007411 224.0
HFD2_k127_7382819_7 O-Antigen ligase - - - 0.0000000000000000000000000000000000000000000000000003482 203.0
HFD2_k127_7382819_8 polysaccharide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000008423 200.0
HFD2_k127_7382819_9 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000001676 196.0
HFD2_k127_7414060_0 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase K02031,K02032 - - 2.05e-242 763.0
HFD2_k127_7414060_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 3.606e-235 771.0
HFD2_k127_7414060_10 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000005719 114.0
HFD2_k127_7414060_11 Methyltransferase domain - - - 0.0000000000000000001362 89.0
HFD2_k127_7414060_12 Ion channel - - - 0.00000000003931 74.0
HFD2_k127_7414060_2 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005057 591.0
HFD2_k127_7414060_3 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009217 477.0
HFD2_k127_7414060_4 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 310.0
HFD2_k127_7414060_5 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002009 293.0
HFD2_k127_7414060_6 Nucleotidyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000893 250.0
HFD2_k127_7414060_7 glycosyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000001292 227.0
HFD2_k127_7414060_8 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000121 212.0
HFD2_k127_7414060_9 - - - - 0.0000000000000000000000000000000000000000531 155.0
HFD2_k127_7436197_0 Aerotolerance regulator N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004539 587.0
HFD2_k127_7436197_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007526 388.0
HFD2_k127_7436197_2 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 356.0
HFD2_k127_7436197_3 Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring K18816 - 2.3.1.82 0.0000000000000000000000000000000002475 139.0
HFD2_k127_7447436_0 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 3.373e-219 696.0
HFD2_k127_7447436_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 1.619e-205 666.0
HFD2_k127_7447436_10 cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004817 358.0
HFD2_k127_7447436_11 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.0000000000000000000000000000000000000000000001893 177.0
HFD2_k127_7447436_12 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000002712 146.0
HFD2_k127_7447436_13 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.0000000000000000000000001655 108.0
HFD2_k127_7447436_2 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 574.0
HFD2_k127_7447436_3 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 479.0
HFD2_k127_7447436_4 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005389 484.0
HFD2_k127_7447436_5 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 496.0
HFD2_k127_7447436_6 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 458.0
HFD2_k127_7447436_7 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004506 469.0
HFD2_k127_7447436_8 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929,K15792 - 6.3.2.10,6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 456.0
HFD2_k127_7447436_9 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 405.0
HFD2_k127_7447711_0 Atp-dependent helicase K03578 - 3.6.4.13 9.165e-316 994.0
HFD2_k127_7447711_1 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 4.752e-201 635.0
HFD2_k127_7447711_10 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008754 276.0
HFD2_k127_7447711_11 RadC-like JAB domain K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001123 281.0
HFD2_k127_7447711_12 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000001667 252.0
HFD2_k127_7447711_13 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.00000000000000000000000000000000000000000000000000000000001014 227.0
HFD2_k127_7447711_14 Phasin protein - - - 0.0000000000000000000000000000000000000000000000000001499 193.0
HFD2_k127_7447711_15 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000000008839 183.0
HFD2_k127_7447711_16 Belongs to the ClpA ClpB family K03694 - - 0.00000000000000000000000000000000000000000000003043 171.0
HFD2_k127_7447711_17 Etoposide-induced protein 2.4 (EI24) - - - 0.0000000000000000000000000000000000000002705 161.0
HFD2_k127_7447711_18 Ribosomal L28 family K02902 - - 0.0000000000000000000000004304 116.0
HFD2_k127_7447711_19 Protein of unknown function (DUF3108) - - - 0.0000000000000000000003986 106.0
HFD2_k127_7447711_2 PFAM fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002369 545.0
HFD2_k127_7447711_20 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000000001583 84.0
HFD2_k127_7447711_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003586 481.0
HFD2_k127_7447711_4 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009168 439.0
HFD2_k127_7447711_5 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 428.0
HFD2_k127_7447711_6 Glutaredoxin-family domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000885 395.0
HFD2_k127_7447711_7 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000851 363.0
HFD2_k127_7447711_8 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002535 331.0
HFD2_k127_7447711_9 Probable molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002253 285.0
HFD2_k127_7452216_0 GIY-YIG type nucleases (URI domain) K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 457.0
HFD2_k127_7452216_1 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 316.0
HFD2_k127_7452216_2 Belongs to the GST superfamily K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 284.0
HFD2_k127_7452216_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006469 278.0
HFD2_k127_7452216_4 OsmC-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001092 237.0
HFD2_k127_7452216_5 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000006875 123.0
HFD2_k127_7452216_6 PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding K07226 - - 0.000000000000000000000009775 106.0
HFD2_k127_7460780_0 GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004296 507.0
HFD2_k127_7460780_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 383.0
HFD2_k127_7460780_2 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005831 332.0
HFD2_k127_7460780_3 Transport of potassium into the cell K03549 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004203 248.0
HFD2_k127_7460780_4 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000005749 217.0
HFD2_k127_7460780_5 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.0000000000000000000000009251 109.0
HFD2_k127_746191_0 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate K00381,K00392 - 1.8.1.2,1.8.7.1 1.018e-257 804.0
HFD2_k127_746191_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 1.577e-237 746.0
HFD2_k127_746191_10 Tetrapyrrole (Corrin/Porphyrin) Methylases K02303 - 2.1.1.107 0.0000000000000000000000000000000000000000000000000000000000000000001287 241.0
HFD2_k127_746191_11 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.00000000000000000000000000000000000000000004178 167.0
HFD2_k127_746191_12 protein conserved in bacteria - - - 0.0000000000000000000000000009526 118.0
HFD2_k127_746191_2 homogentisate 1,2-dioxygenase K00451 - 1.13.11.5 6.895e-195 615.0
HFD2_k127_746191_3 PFAM PHB de-polymerase domain protein K05973 - 3.1.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006959 532.0
HFD2_k127_746191_4 Fumarylacetoacetase N-terminal K01555 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002076 503.0
HFD2_k127_746191_5 Transcriptional regulator K13634 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 429.0
HFD2_k127_746191_6 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007982 415.0
HFD2_k127_746191_7 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 320.0
HFD2_k127_746191_8 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008802 304.0
HFD2_k127_746191_9 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 291.0
HFD2_k127_7480180_0 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 489.0
HFD2_k127_7480180_1 ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004227 393.0
HFD2_k127_7480180_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000214 240.0
HFD2_k127_7480180_3 ethanolamine utilization protein K04019 GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009,GO:0071704,GO:1901564 - 0.000000000000000000000000000000000000000000000000000004597 208.0
HFD2_k127_7480180_4 High-affinity nickel-transport protein K07241 - - 0.00000000000000000000000000000000000000000000000000001835 198.0
HFD2_k127_7480180_5 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000002309 186.0
HFD2_k127_7480180_6 Tripartite tricarboxylate transporter TctA family - - - 0.0000000000000000000000000000000000000004319 153.0
HFD2_k127_750605_0 Class II Aldolase and Adducin N-terminal domain - - - 3.781e-262 822.0
HFD2_k127_750605_1 DeoC/LacD family aldolase K08321,K11645 GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 2.3.1.245,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006319 462.0
HFD2_k127_750605_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 340.0
HFD2_k127_750605_3 Transport and Golgi organisation 2 - - - 0.0000000000000000000000000000000000000000000000004303 184.0
HFD2_k127_750605_4 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000001327 153.0
HFD2_k127_750605_5 Domain of unknown function (DUF4936) - - - 0.00000000001037 68.0
HFD2_k127_750605_6 protein conserved in bacteria K09780 - - 0.000000001648 70.0
HFD2_k127_7515463_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004754 546.0
HFD2_k127_7515463_1 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000003005 220.0
HFD2_k127_752723_0 DEAD/H associated K03724 - - 0.0 1455.0
HFD2_k127_752723_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.0 1208.0
HFD2_k127_752723_10 CRS1_YhbY K07574 - - 0.00000000000000000000007424 100.0
HFD2_k127_752723_2 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 1.57e-213 672.0
HFD2_k127_752723_3 PFAM Aldehyde dehydrogenase K00128 - 1.2.1.3 3.221e-206 649.0
HFD2_k127_752723_4 KR domain K00038 - 1.1.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005171 385.0
HFD2_k127_752723_5 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 380.0
HFD2_k127_752723_6 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000006366 159.0
HFD2_k127_752723_7 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000000000001185 164.0
HFD2_k127_752723_8 diguanylate cyclase - - - 0.000000000000000000000000000000000002029 152.0
HFD2_k127_752723_9 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000005661 99.0
HFD2_k127_7540924_0 Histidine kinase-like ATPases - - - 6.756e-282 919.0
HFD2_k127_7540924_1 His Kinase A (phosphoacceptor) domain - - - 6.979e-198 664.0
HFD2_k127_7540924_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 592.0
HFD2_k127_7540924_3 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002844 406.0
HFD2_k127_7540924_4 Ornithine cyclodeaminase/mu-crystallin family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 291.0
HFD2_k127_7540924_5 3-hydroxyacyl-coa dehydrogenase K07516 - 1.1.1.35 0.000000000000000000000000000000000000000000000000000000000000000000008152 237.0
HFD2_k127_7540924_6 SMART cyclic nucleotide-binding K10914 - - 0.00000000000000000000000000000000000000000000000000003524 201.0
HFD2_k127_7540924_7 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000000001357 190.0
HFD2_k127_7540924_8 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000002264 159.0
HFD2_k127_7540924_9 PFAM response regulator receiver K11443 - - 0.000000000000000000000000000006017 138.0
HFD2_k127_755194_0 Cytochrome b(N-terminal)/b6/petB - - - 6.386e-235 742.0
HFD2_k127_755194_1 Cytochrome C and Quinol oxidase polypeptide I - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 555.0
HFD2_k127_755194_2 PFAM ATP-binding region ATPase domain protein K07645 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006449 420.0
HFD2_k127_755194_3 Transcriptional regulatory protein, C terminal K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 300.0
HFD2_k127_755194_4 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007301 248.0
HFD2_k127_7644953_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 612.0
HFD2_k127_7644953_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 583.0
HFD2_k127_7644953_2 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002002 318.0
HFD2_k127_7644953_3 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000003734 257.0
HFD2_k127_7644953_4 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000003692 251.0
HFD2_k127_7681630_0 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 606.0
HFD2_k127_7681630_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 393.0
HFD2_k127_7681630_2 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002591 332.0
HFD2_k127_7681630_3 Bacterial transcriptional repressor C-terminal K16137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003982 265.0
HFD2_k127_7681630_4 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000005583 233.0
HFD2_k127_7681630_5 COG2346, Truncated hemoglobins K06886 - - 0.000000000000000000000000000000000000001647 151.0
HFD2_k127_7681630_6 - - - - 0.0000000000000000005689 100.0
HFD2_k127_7681630_7 - - - - 0.000000000000000003439 84.0
HFD2_k127_7755243_0 Protein of unknown function (DUF993) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006583 511.0
HFD2_k127_7755243_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 510.0
HFD2_k127_7755243_2 Trap-type c4-dicarboxylate transport system, small permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000002138 238.0
HFD2_k127_7755243_3 TIGRFAM TRAP transporter, DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000002654 220.0
HFD2_k127_7755243_4 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000002515 220.0
HFD2_k127_7755243_5 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000846 68.0
HFD2_k127_7769475_0 4Fe-4S dicluster domain - - - 0.0 1166.0
HFD2_k127_7769475_1 Belongs to the IlvD Edd family - - - 5.442e-271 865.0
HFD2_k127_7769475_10 - - - - 0.0000000000000000000000377 106.0
HFD2_k127_7769475_2 Protein of unknown function, DUF255 K06888 - - 7.811e-251 790.0
HFD2_k127_7769475_3 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001713 598.0
HFD2_k127_7769475_4 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 353.0
HFD2_k127_7769475_5 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000208 263.0
HFD2_k127_7769475_6 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000003235 208.0
HFD2_k127_7769475_7 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component K11688 - - 0.00000000000000000000000000000000000000000000000000000000198 204.0
HFD2_k127_7769475_8 Cytochrome c K08738 - - 0.00000000000000000000000000001164 136.0
HFD2_k127_7769475_9 Extracellular liganD-binding receptor K01999 - - 0.0000000000000000000000000004019 117.0
HFD2_k127_7781535_0 B12 binding domain K00548 - 2.1.1.13 0.0 1665.0
HFD2_k127_7781535_1 Ammonium Transporter K03320 - - 1.455e-220 694.0
HFD2_k127_7781535_10 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) K16165 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0008948,GO:0016787,GO:0016822,GO:0016823,GO:0016829,GO:0016830,GO:0016831,GO:0018773,GO:0031974,GO:0031981,GO:0034545,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0070013 3.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005508 281.0
HFD2_k127_7781535_11 maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000484 276.0
HFD2_k127_7781535_12 Belongs to the P(II) protein family K04752 - - 0.000000000000000000000000000000000000000000000000000000003753 200.0
HFD2_k127_7781535_13 Protocatechuate 4,5-dioxygenase K04100 - 1.13.11.8 0.00000000000000000000000000000000000000000000000000005062 190.0
HFD2_k127_7781535_14 Histidine triad (Hit) protein K02503 - - 0.00000000000000000000000000000000000000000000000001456 185.0
HFD2_k127_7781535_15 Outer membrane lipoprotein K06077 - - 0.00000000000000000000000000000000000000307 150.0
HFD2_k127_7781535_16 zinc-ribbon domain - - - 0.00000000000000000000000000000004617 130.0
HFD2_k127_7781535_17 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000007874 124.0
HFD2_k127_7781535_18 Thioesterase superfamily - - - 0.00000000000000000000001817 106.0
HFD2_k127_7781535_19 Membrane fusogenic activity K09806 - - 0.000000000000000004005 86.0
HFD2_k127_7781535_2 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 6.424e-194 616.0
HFD2_k127_7781535_3 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007692 607.0
HFD2_k127_7781535_4 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006517 470.0
HFD2_k127_7781535_5 COG0524 Sugar kinases, ribokinase family K00856 - 2.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 437.0
HFD2_k127_7781535_6 Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols K04101 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 422.0
HFD2_k127_7781535_7 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005248 413.0
HFD2_k127_7781535_8 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 340.0
HFD2_k127_7781535_9 Bacterial protein of unknown function (Gcw_chp) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 331.0
HFD2_k127_7801322_0 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing - - - 2.401e-277 869.0
HFD2_k127_7801322_1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009981 619.0
HFD2_k127_7801322_2 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 521.0
HFD2_k127_7801322_3 lytic transglycosylase activity - - - 0.0000000000000000000000000000000000000000000000000000000000005677 222.0
HFD2_k127_7801322_4 MerR, DNA binding K13639 - - 0.0000000000000000000000000000000000000000000000000000000003111 205.0
HFD2_k127_7801322_5 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000000000000000000000000000002472 190.0
HFD2_k127_7801322_6 methyltransferase - - - 0.000000000000000000000000000000000225 140.0
HFD2_k127_7801322_7 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000003684 115.0
HFD2_k127_7801322_8 CsbD-like - - - 0.00000000000222 70.0
HFD2_k127_7864800_0 serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000849 329.0
HFD2_k127_7864800_1 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000131 252.0
HFD2_k127_7864800_2 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000008534 247.0
HFD2_k127_7864800_3 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000007163 235.0
HFD2_k127_7864800_4 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000002647 166.0
HFD2_k127_7864800_5 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000001604 171.0
HFD2_k127_7864800_6 cheY-homologous receiver domain K03413 - - 0.000000000000000001705 88.0
HFD2_k127_7864800_7 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000001187 90.0
HFD2_k127_7865896_0 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004625 243.0
HFD2_k127_7865896_1 KaiC K08482 - - 0.00000000000000000000000000000000000000000000000005452 183.0
HFD2_k127_7865896_2 Belongs to the glutamine synthetase family K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000964 171.0
HFD2_k127_7865896_3 KaiB domain K08481 - - 0.0000000000000000000000000000000004812 142.0
HFD2_k127_7865896_4 His Kinase A (phosphoacceptor) domain - - - 0.0000000000003871 77.0
HFD2_k127_7872796_0 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004766 512.0
HFD2_k127_7872796_1 Elongation factor SelB, winged helix - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 514.0
HFD2_k127_7872796_10 Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility - - - 0.000000749 60.0
HFD2_k127_7872796_2 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005325 448.0
HFD2_k127_7872796_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001183 269.0
HFD2_k127_7872796_4 catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000249 246.0
HFD2_k127_7872796_5 ABC transporter substrate binding protein - - - 0.0000000000000000000000000000000000000000000000000000006932 207.0
HFD2_k127_7872796_6 DsbA oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000001883 190.0
HFD2_k127_7872796_7 membrane - - - 0.000000000000000000000000000000000000000004111 163.0
HFD2_k127_7872796_8 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 0.0000000000000000000000000000000000000002068 152.0
HFD2_k127_7932263_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 6.885e-233 735.0
HFD2_k127_7932263_1 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000328 461.0
HFD2_k127_7932263_2 Branched-chain amino acid transport system / permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000317 378.0
HFD2_k127_7932263_3 Nitrile hydratase K01721,K20807 - 4.2.1.84 0.000000000000000000000000000000000000000000000000000000000000003311 227.0
HFD2_k127_7932263_4 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000006941 167.0
HFD2_k127_7932263_5 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.00000000000000000000000000000000003043 143.0
HFD2_k127_7932263_6 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.0000000000000000000968 99.0
HFD2_k127_7933465_0 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005871 479.0
HFD2_k127_7933465_1 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006526 389.0
HFD2_k127_7933465_2 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 359.0
HFD2_k127_7973436_0 Peptidase family U32 K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005276 478.0
HFD2_k127_7973436_1 Peptidase U32 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 339.0
HFD2_k127_7973436_2 SCP-2 sterol transfer family - - - 0.0000000003836 72.0
HFD2_k127_8011318_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 9.642e-272 858.0
HFD2_k127_8011318_1 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 502.0
HFD2_k127_8011318_10 COG0526 Thiol-disulfide isomerase and thioredoxins K00384 - 1.8.1.9 0.00000000000000000000004414 105.0
HFD2_k127_8011318_11 Domain of unknown function (DUF4124) - - - 0.0002003 45.0
HFD2_k127_8011318_2 Na+ dependent nucleoside transporter N-terminus K03317 GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505,GO:1901642 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006331 444.0
HFD2_k127_8011318_3 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 337.0
HFD2_k127_8011318_4 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003667 316.0
HFD2_k127_8011318_5 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001272 288.0
HFD2_k127_8011318_6 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000000004768 166.0
HFD2_k127_8011318_7 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000002032 152.0
HFD2_k127_8011318_8 Predicted membrane protein (DUF2069) - - - 0.000000000000000000000000000000000008748 139.0
HFD2_k127_8011318_9 Domain of unknown function (DUF4864) - - - 0.00000000000000000000000001168 118.0
HFD2_k127_8017288_0 Cobalamin synthesis protein cobW C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002046 458.0
HFD2_k127_8017288_1 phosphate-selective porin O and P - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 434.0
HFD2_k127_8017288_2 Periplasmic solute binding protein K02077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008172 369.0
HFD2_k127_8017288_3 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009535 291.0
HFD2_k127_8017288_4 ABC-3 protein K02075 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003024 291.0
HFD2_k127_8017288_5 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000001912 61.0
HFD2_k127_8045007_0 ABC transporter K06147,K18893 - - 1.722e-247 782.0
HFD2_k127_8045007_1 Peptidase family M20/M25/M40 - - - 1.032e-205 648.0
HFD2_k127_8045007_10 COG1943 Transposase and inactivated derivatives K07491 - - 0.0000000000000000000000000000000000000000000000000000000000008992 218.0
HFD2_k127_8045007_11 Belongs to the CinA family - - - 0.0000000000000000000000000000000000000000000000000001223 190.0
HFD2_k127_8045007_12 paraquat-inducible protein b K06192 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0016020,GO:0016021,GO:0016043,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071840,GO:0071944,GO:0120009 - 0.00000000000000000000000000000000000000000000000009656 184.0
HFD2_k127_8045007_13 NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000001658 178.0
HFD2_k127_8045007_14 Glutathione S-transferase K00799,K11209 - 2.5.1.18 0.000000000000000000000000000000000000000004874 162.0
HFD2_k127_8045007_15 Domain of unknown function (DUF4437) - - - 0.00000000000000000000000000000000000000001638 158.0
HFD2_k127_8045007_16 Chromate K07240 - - 0.0000000000000000000000000000000000002161 159.0
HFD2_k127_8045007_17 Chromate transporter K07240 - - 0.0000000000000000000000000000000000316 148.0
HFD2_k127_8045007_18 - - - - 0.0000000000000000000000000000000001769 140.0
HFD2_k127_8045007_19 PFAM Prokaryotic diacylglycerol kinase K00887,K00901 - 2.7.1.107,2.7.1.66 0.0000000000000000005672 93.0
HFD2_k127_8045007_2 Epoxide hydrolase N terminus K01253 - 3.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009159 497.0
HFD2_k127_8045007_20 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.0000004734 52.0
HFD2_k127_8045007_21 Bacterial protein of unknown function (DUF883) - GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0043021,GO:0043024,GO:0044464,GO:0044877,GO:0060187,GO:0071944 - 0.000001571 55.0
HFD2_k127_8045007_22 Cation transport regulator - - - 0.0001375 53.0
HFD2_k127_8045007_3 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 475.0
HFD2_k127_8045007_4 chromosome segregation K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 441.0
HFD2_k127_8045007_5 Histidine kinase K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001918 338.0
HFD2_k127_8045007_6 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007941 301.0
HFD2_k127_8045007_7 thiamine-containing compound biosynthetic process K02051,K15553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000044 289.0
HFD2_k127_8045007_8 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006007 284.0
HFD2_k127_8045007_9 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000001203 246.0
HFD2_k127_8055358_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 471.0
HFD2_k127_8055358_1 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 417.0
HFD2_k127_8055358_2 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 377.0
HFD2_k127_8055358_3 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 366.0
HFD2_k127_8055358_4 DREV methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000004079 210.0
HFD2_k127_8055358_5 O-Antigen ligase - - - 0.00000000000000000000000000000000000000000000000000002359 202.0
HFD2_k127_8055358_6 - - - - 0.0000000000000000000000273 114.0
HFD2_k127_8055358_7 ABC transporter K06147,K06148 - - 0.0000000001004 63.0
HFD2_k127_8055358_8 GtrA-like protein - - - 0.00000009797 64.0
HFD2_k127_8063307_0 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 380.0
HFD2_k127_8063307_1 HlyD membrane-fusion protein of T1SS K02022 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 329.0
HFD2_k127_8063307_2 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004545 293.0
HFD2_k127_8063307_3 COG4618 ABC-type protease lipase transport system, ATPase and permease components K16299 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006801 261.0
HFD2_k127_8063307_4 DNA polymerase III, delta K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000002187 231.0
HFD2_k127_8063307_5 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000001183 210.0
HFD2_k127_8063307_6 Belongs to the GcvT family K06980 - - 0.0000000000000000000000000000000000000000000000000007801 196.0
HFD2_k127_8063307_7 Protein of unknown function (DUF1178) - - - 0.00000000000000000000000000000001038 132.0
HFD2_k127_8093229_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 1.42e-198 633.0
HFD2_k127_8093229_1 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 531.0
HFD2_k127_8093229_10 helix_turn_helix, Lux Regulon K07684,K07693 - - 0.00000000005267 73.0
HFD2_k127_8093229_2 NADH:flavin oxidoreductase / NADH oxidase family K00219 - 1.3.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005219 471.0
HFD2_k127_8093229_3 enoyl-CoA hydratase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006885 327.0
HFD2_k127_8093229_4 Metal binding domain of Ada K00567,K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000003005 252.0
HFD2_k127_8093229_5 Phenylacetic acid degradation protein PaaY K02617,K08279 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001934 246.0
HFD2_k127_8093229_6 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000169 230.0
HFD2_k127_8093229_7 PFAM isochorismatase hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000004421 224.0
HFD2_k127_8093229_8 Belongs to the enoyl-CoA hydratase isomerase family K01692,K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000001323 211.0
HFD2_k127_8093229_9 phenylacetic acid degradation protein K02614 - - 0.0000000000000000000000000000000000000000006556 162.0
HFD2_k127_8107044_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.408e-314 975.0
HFD2_k127_8107044_1 Fumarate reductase flavoprotein C-term K00239,K00244 - 1.3.5.1,1.3.5.4 1.027e-267 847.0
HFD2_k127_8107044_10 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000017 229.0
HFD2_k127_8107044_11 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000003287 216.0
HFD2_k127_8107044_12 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.00000000000000000000000000000000000000000000000000000005695 201.0
HFD2_k127_8107044_13 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000000000000000002609 192.0
HFD2_k127_8107044_14 PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000003264 177.0
HFD2_k127_8107044_15 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.000000000000000000000000121 121.0
HFD2_k127_8107044_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004711 554.0
HFD2_k127_8107044_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005839 527.0
HFD2_k127_8107044_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 435.0
HFD2_k127_8107044_5 Tyrosine recombinase xerD K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009528 353.0
HFD2_k127_8107044_6 Belongs to the LDH2 MDH2 oxidoreductase family K13609,K16844 - 1.1.1.338,1.5.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 359.0
HFD2_k127_8107044_7 NMT1-like family K07080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000715 298.0
HFD2_k127_8107044_8 dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000005045 262.0
HFD2_k127_8107044_9 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000005169 237.0
HFD2_k127_8112537_0 carbohydrate binding - - - 0.0 1139.0
HFD2_k127_8112537_1 ABC transporter C-terminal domain K15738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008569 613.0
HFD2_k127_8112537_10 Protein of unknown function (DUF1643) - - - 0.0000000000000000000000000000000000000000000000002482 184.0
HFD2_k127_8112537_11 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000001673 186.0
HFD2_k127_8112537_12 MlaC protein K07323 - - 0.000000000000000000000000000000000000000002519 168.0
HFD2_k127_8112537_13 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000003049 156.0
HFD2_k127_8112537_14 Restriction endonuclease K07448 - - 0.00000000000000000000000000000000000000004763 158.0
HFD2_k127_8112537_15 - - - - 0.000000000000000000000000000000000000000954 149.0
HFD2_k127_8112537_16 Topoisomerase DNA binding C4 zinc finger K07448 - - 0.00000000000000000000000000000000000002317 154.0
HFD2_k127_8112537_17 - - - - 0.000000000000000000000000000000001311 143.0
HFD2_k127_8112537_18 nucleic-acid-binding protein, contains PIN domain - - - 0.00000000000000000000000000000001651 145.0
HFD2_k127_8112537_19 TIGRFAM Addiction module toxin, RelE StbE K19092 - - 0.0000000000000000000000000000006389 128.0
HFD2_k127_8112537_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 508.0
HFD2_k127_8112537_20 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000000000000000006907 126.0
HFD2_k127_8112537_21 nucleic-acid-binding protein, contains PIN domain - - - 0.0000000000000000000000000008109 119.0
HFD2_k127_8112537_22 PIN domain - - - 0.00000000000000000000000002374 113.0
HFD2_k127_8112537_23 KaiB K08481 - - 0.000000000000000001115 91.0
HFD2_k127_8112537_24 - - - - 0.000000000000000179 90.0
HFD2_k127_8112537_25 - - - - 0.0000000000003462 72.0
HFD2_k127_8112537_3 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 481.0
HFD2_k127_8112537_4 KaiC K08482 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007298 455.0
HFD2_k127_8112537_5 esterase K01432 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008324 338.0
HFD2_k127_8112537_6 HpcH/HpaI aldolase/citrate lyase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006984 321.0
HFD2_k127_8112537_7 Restriction endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000008599 234.0
HFD2_k127_8112537_8 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000008106 230.0
HFD2_k127_8112537_9 Crp-like helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000001565 224.0
HFD2_k127_8127128_0 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 310.0
HFD2_k127_8127128_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 312.0
HFD2_k127_8130248_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1101.0
HFD2_k127_8130248_1 PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, N-terminal domain K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 1.838e-246 765.0
HFD2_k127_8130248_10 Aminotransferase class IV K00824 - 2.6.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006125 366.0
HFD2_k127_8130248_11 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004874 306.0
HFD2_k127_8130248_12 TonB family K03832 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006369 284.0
HFD2_k127_8130248_13 Belongs to the UPF0301 (AlgH) family K07735 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004046 274.0
HFD2_k127_8130248_14 Protein of unknown function (DUF4197) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001241 275.0
HFD2_k127_8130248_15 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000004029 261.0
HFD2_k127_8130248_16 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000000000000000000000000000000000000000005814 244.0
HFD2_k127_8130248_17 Ribosomal protein L11 methyltransferase (PrmA) K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000009174 246.0
HFD2_k127_8130248_18 Pyrimidine operon attenuation protein uracil phosphoribosyltransferase K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000006795 211.0
HFD2_k127_8130248_19 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000001735 203.0
HFD2_k127_8130248_2 Mur ligase family, catalytic domain K02558 - 6.3.2.45 1.863e-202 649.0
HFD2_k127_8130248_20 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000004353 197.0
HFD2_k127_8130248_21 Uncharacterised protein family (UPF0227) K07000 - - 0.0000000000000000000000000000000000000000000000000001785 201.0
HFD2_k127_8130248_22 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000000000114 194.0
HFD2_k127_8130248_23 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000000000000000000005905 186.0
HFD2_k127_8130248_24 mRNA catabolic process - - - 0.00000000000000000000000000000000000000000000006275 176.0
HFD2_k127_8130248_25 Rubredoxin - - - 0.00000000000000000000000000000001074 127.0
HFD2_k127_8130248_26 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000000007746 127.0
HFD2_k127_8130248_27 Belongs to the UPF0250 family K09158 - - 0.00000000000000000000000000000764 121.0
HFD2_k127_8130248_28 Protein of unknown function (DUF2782) - - - 0.000000000000000002917 87.0
HFD2_k127_8130248_29 zinc-ribbon domain - - - 0.00000000004596 69.0
HFD2_k127_8130248_3 RNB K01147 - 3.1.13.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 612.0
HFD2_k127_8130248_4 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 594.0
HFD2_k127_8130248_5 dihydroorotase K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 574.0
HFD2_k127_8130248_6 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006194 512.0
HFD2_k127_8130248_7 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007504 475.0
HFD2_k127_8130248_8 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 481.0
HFD2_k127_8130248_9 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 450.0
HFD2_k127_8147479_0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 1.909e-266 832.0
HFD2_k127_8147479_1 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.000000000000000000000000000000000000000000000000001402 200.0
HFD2_k127_8150_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 7.914e-195 617.0
HFD2_k127_8150_1 Histone methylation protein DOT1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001789 250.0
HFD2_k127_8150_2 binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000000000000000000000004987 207.0
HFD2_k127_8150_3 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 0.0000000000000000000000000000000000000000000000000000000005831 201.0
HFD2_k127_8150_4 Iron-binding zinc finger CDGSH type - - - 0.0000000000000000000000000000000001255 136.0
HFD2_k127_8150_5 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000003101 108.0
HFD2_k127_8165083_0 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007399 519.0
HFD2_k127_8165083_1 Enoyl-CoA hydratase/isomerase K08299 - 4.2.1.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 361.0
HFD2_k127_8165083_2 tRNA wobble adenosine to inosine editing K01485,K11991 - 3.5.4.1,3.5.4.33 0.000000000000000000000000000000000000000000000000000000001592 204.0
HFD2_k127_8183607_0 AcrB/AcrD/AcrF family - - - 0.0 1134.0
HFD2_k127_8183607_1 Belongs to the 5'-nucleotidase family K11751,K17224 - 3.1.3.5,3.6.1.45 5.883e-258 805.0
HFD2_k127_8183607_10 Biotin-lipoyl like - - - 0.0000000000000000000000000000000000000000000000000000000008259 218.0
HFD2_k127_8183607_11 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000000000000000000001441 196.0
HFD2_k127_8183607_12 Cytochrome c K17223 - - 0.000000000000000000000000000000000000000000000001044 191.0
HFD2_k127_8183607_13 sulfur oxidation protein SoxY K17226 - - 0.00000000000000000000000000000000000000000006254 165.0
HFD2_k127_8183607_14 PFAM Thioredoxin domain K03672 - 1.8.1.8 0.0000000000000000000000000000000009851 138.0
HFD2_k127_8183607_15 Sulphur oxidation protein SoxZ K17227 - - 0.0000000000000000000000000000001141 126.0
HFD2_k127_8183607_16 FixH K09926 - - 0.0000000000000000000000000000006951 140.0
HFD2_k127_8183607_17 Prokaryotic cytochrome b561 - - - 0.0000000000000000000000003022 112.0
HFD2_k127_8183607_18 - - - - 0.000000000000000000008206 101.0
HFD2_k127_8183607_19 Protein of unknown function (DUF2892) - - - 0.0000000000000000002621 89.0
HFD2_k127_8183607_2 IG-like fold at C-terminal of FixG, putative oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009215 565.0
HFD2_k127_8183607_20 Cbb3-type cytochrome oxidase component FixQ K00407 - - 0.0008605 49.0
HFD2_k127_8183607_3 Cytochrome c oxidase, subunit K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 366.0
HFD2_k127_8183607_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003077 346.0
HFD2_k127_8183607_5 cytochrome c oxidase, cbb3-type, subunit II K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 322.0
HFD2_k127_8183607_6 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 311.0
HFD2_k127_8183607_7 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003828 265.0
HFD2_k127_8183607_8 helix_turn_helix, cAMP Regulatory protein K01420 - - 0.00000000000000000000000000000000000000000000000000000000000000001194 230.0
HFD2_k127_8183607_9 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000002419 212.0
HFD2_k127_8195893_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K21307 - 1.8.5.6 0.0 1544.0
HFD2_k127_8195893_1 Flavocytochrome c sulphide dehydrogenase, flavin-binding K05301,K17218 - 1.8.2.1,1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 499.0
HFD2_k127_8195893_10 Cytochrome c, class I - - - 0.00000000000000005506 85.0
HFD2_k127_8195893_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K21308 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005033 459.0
HFD2_k127_8195893_3 Phosphoribulokinase / Uridine kinase family K00855 - 2.7.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008465 415.0
HFD2_k127_8195893_4 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 349.0
HFD2_k127_8195893_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 345.0
HFD2_k127_8195893_6 DMSO reductase anchor subunit (DmsC) K21309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 330.0
HFD2_k127_8195893_7 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000000000000000000000000000008878 234.0
HFD2_k127_8195893_8 reductase beta subunit K00395 - 1.8.99.2 0.00000000000000000000000000000000000000000000000000000000006523 204.0
HFD2_k127_8195893_9 - - - - 0.00000000000000000000000000000887 134.0
HFD2_k127_8223780_0 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis - - - 8.644e-294 907.0
HFD2_k127_8223780_1 - - - - 6.814e-227 707.0
HFD2_k127_8223780_10 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 426.0
HFD2_k127_8223780_11 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 413.0
HFD2_k127_8223780_12 ABC transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007035 361.0
HFD2_k127_8223780_13 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009081 298.0
HFD2_k127_8223780_14 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 295.0
HFD2_k127_8223780_15 Metallopeptidase family M24 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001239 293.0
HFD2_k127_8223780_16 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein K20448 - 1.17.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003603 297.0
HFD2_k127_8223780_17 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004962 275.0
HFD2_k127_8223780_18 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005597 266.0
HFD2_k127_8223780_19 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006765 284.0
HFD2_k127_8223780_2 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.347e-220 699.0
HFD2_k127_8223780_20 Male sterility protein K22025 - 1.1.1.410 0.0000000000000000000000000000000000000000000000000000000000000000000000326 262.0
HFD2_k127_8223780_21 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000001482 251.0
HFD2_k127_8223780_22 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002186 241.0
HFD2_k127_8223780_23 Thioredoxin K05838 - - 0.000000000000000000000000000000000000000000000000000002755 204.0
HFD2_k127_8223780_24 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000004647 203.0
HFD2_k127_8223780_25 Protein of unknown function (DUF3014) - - - 0.00000000000000000000000000000000000000000000000000006459 198.0
HFD2_k127_8223780_26 PAS domain - - - 0.00000000000000000000000000000000000000000000000001131 183.0
HFD2_k127_8223780_27 COG1192 ATPases involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000003963 181.0
HFD2_k127_8223780_28 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000001524 167.0
HFD2_k127_8223780_29 ABC transporter related - - - 0.000000000000000000000000000000000000001447 164.0
HFD2_k127_8223780_3 Protein of unknown function (DUF1343) - - - 3.206e-209 657.0
HFD2_k127_8223780_30 - - - - 0.000000000000000000000000000000005962 134.0
HFD2_k127_8223780_31 PAS fold K02484 - 2.7.13.3 0.0000000000000000000000000009764 117.0
HFD2_k127_8223780_32 COG3090 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.0000000000000000000000000196 114.0
HFD2_k127_8223780_33 bacterial (prokaryotic) histone like domain K03530 - - 0.000000000000000005369 100.0
HFD2_k127_8223780_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 2.18e-199 630.0
HFD2_k127_8223780_5 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 638.0
HFD2_k127_8223780_6 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000695 513.0
HFD2_k127_8223780_7 aerobic-type carbon monoxide dehydrogenase, large subunit CoxL - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008236 501.0
HFD2_k127_8223780_8 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 490.0
HFD2_k127_8223780_9 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004496 447.0
HFD2_k127_8251224_0 NADH-ubiquinone oxidoreductase chain 49kDa - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002861 572.0
HFD2_k127_8251224_1 Sigma-70 region 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 514.0
HFD2_k127_8251224_2 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009274 324.0
HFD2_k127_8251224_3 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000347 267.0
HFD2_k127_8251224_4 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000000001149 198.0
HFD2_k127_8251224_5 YCII-related domain - - - 0.000000000000000000000000000000000000000000000008289 181.0
HFD2_k127_8251224_6 Protein of unknown function (DUF1428) - - - 0.0000000000000000000000000000000000000000000002064 180.0
HFD2_k127_8251224_7 PFAM Glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.00000000000000000000000000000000000002809 145.0
HFD2_k127_8251224_8 Domain of unknown function (DUF427) - - - 0.00000000000000000000000001289 118.0
HFD2_k127_8251224_9 Glyoxalase-like domain K06996 - - 0.0000000000000001474 84.0
HFD2_k127_825995_0 UDP binding domain K02474 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 593.0
HFD2_k127_825995_1 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001755 278.0
HFD2_k127_825995_2 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002783 270.0
HFD2_k127_8283248_0 Phosphoesterase family - - - 6.649e-201 641.0
HFD2_k127_8283248_1 Phosphoesterase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 632.0
HFD2_k127_8283248_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 606.0
HFD2_k127_8283248_3 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009465 320.0
HFD2_k127_8283248_4 Class II Aldolase and Adducin N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000004112 222.0
HFD2_k127_8283248_5 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000000000001323 156.0
HFD2_k127_8283248_6 - - - - 0.0000000000000000000000000000006721 133.0
HFD2_k127_8286020_0 Adenylate Guanylate cyclase K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004105 550.0
HFD2_k127_8286020_1 Tetratricopeptide repeat - - - 0.000000000000000000000003928 104.0
HFD2_k127_8311223_0 Tartrate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003116 552.0
HFD2_k127_8311223_1 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005499 549.0
HFD2_k127_8311223_10 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000004905 205.0
HFD2_k127_8311223_11 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789,K14742 - 2.3.1.128 0.0000000000000000000000000000000000000009783 162.0
HFD2_k127_8311223_2 Major Facilitator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 501.0
HFD2_k127_8311223_3 Tartrate dehydrogenase K07246 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.83,1.1.1.93,4.1.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004135 496.0
HFD2_k127_8311223_4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 379.0
HFD2_k127_8311223_5 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 342.0
HFD2_k127_8311223_6 Permeases of the drug metabolite transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 302.0
HFD2_k127_8311223_7 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 303.0
HFD2_k127_8311223_8 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001039 306.0
HFD2_k127_8311223_9 PFAM Peptidase M22, glycoprotease K14742 - - 0.00000000000000000000000000000000000000000000000000002122 209.0
HFD2_k127_8353674_0 Belongs to the glycosyl hydrolase 57 family K16149 - 2.4.1.18 8.588e-194 618.0
HFD2_k127_8353674_1 Haemolysin-III related K11068 - - 0.000000000000000000000000001003 119.0
HFD2_k127_838922_0 AMP-binding enzyme C-terminal domain K00666 - - 1.233e-263 822.0
HFD2_k127_838922_1 Voltage-dependent anion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 539.0
HFD2_k127_838922_10 TPM domain K06872 - - 0.00000000000000000000000000002914 127.0
HFD2_k127_838922_11 enoyl-CoA hydratase - - - 0.00000000008027 65.0
HFD2_k127_838922_2 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009153 442.0
HFD2_k127_838922_3 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003723 423.0
HFD2_k127_838922_4 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009934 356.0
HFD2_k127_838922_5 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002617 284.0
HFD2_k127_838922_6 protein-(glutamine-N5) methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004622 299.0
HFD2_k127_838922_7 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000001167 263.0
HFD2_k127_838922_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000001106 233.0
HFD2_k127_838922_9 glutathione transferase activity K00799 - 2.5.1.18 0.000000000000000000000000000000000002084 148.0
HFD2_k127_8412397_0 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005075 285.0
HFD2_k127_8412397_1 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002353 276.0
HFD2_k127_8412397_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.000000000000000000209 87.0
HFD2_k127_8445949_0 Metallopeptidase family M24 - - - 3.884e-210 660.0
HFD2_k127_8445949_1 Belongs to the IlvD Edd family K01687,K22186 - 4.2.1.82,4.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 565.0
HFD2_k127_8445949_10 TIGRFAM 3-oxoacid CoA-transferase, B subunit K01032 - 2.8.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001046 273.0
HFD2_k127_8445949_2 Belongs to the LDH2 MDH2 oxidoreductase family K13574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 443.0
HFD2_k127_8445949_3 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006052 444.0
HFD2_k127_8445949_4 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 421.0
HFD2_k127_8445949_5 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 378.0
HFD2_k127_8445949_6 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 357.0
HFD2_k127_8445949_7 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 299.0
HFD2_k127_8445949_8 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 293.0
HFD2_k127_8445949_9 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 296.0
HFD2_k127_8478841_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 330.0
HFD2_k127_8478841_1 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186,K16875 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000001468 250.0
HFD2_k127_8478841_2 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001863 249.0
HFD2_k127_8478841_3 Serine aminopeptidase, S33 K01055 - 3.1.1.24 0.00000000000000000000000000000000000000000000000000006333 207.0
HFD2_k127_8478841_4 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.0000000000000000000000000000000004661 132.0
HFD2_k127_8478841_5 Protein of unknown function (DUF1161) - - - 0.00000000000005891 75.0
HFD2_k127_8525404_0 Uncharacterized ACR, YdiU/UPF0061 family - - - 2.853e-225 708.0
HFD2_k127_8525404_1 Acyl-CoA dehydrogenase, middle domain K00252 - 1.3.8.6 2.157e-222 703.0
HFD2_k127_8525404_10 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 355.0
HFD2_k127_8525404_11 Phosphoglycolate phosphatase K22292 - 3.1.3.105 0.000000000000000000000000000000000000000000000000000000000000000000000003272 249.0
HFD2_k127_8525404_12 Belongs to the ompA family K03286 - - 0.00000000000000000000000000000000000000000000000000000000789 203.0
HFD2_k127_8525404_13 Belongs to the ompA family K03286 - - 0.000000000000000000000000000000000000000004002 170.0
HFD2_k127_8525404_14 Universal stress protein family - - - 0.00000000000000000000000000000000000001204 151.0
HFD2_k127_8525404_15 PFAM carboxyl transferase K01615 - 4.1.1.70 0.0000000000000000000000000001161 115.0
HFD2_k127_8525404_16 Dodecin K09165 - - 0.00000000000000000000000001731 111.0
HFD2_k127_8525404_17 - - - - 0.000000000000000007109 91.0
HFD2_k127_8525404_19 EF-hand domain pair - - - 0.0002927 53.0
HFD2_k127_8525404_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 7.171e-217 696.0
HFD2_k127_8525404_3 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 567.0
HFD2_k127_8525404_4 Na+-transporting oxaloacetate decarboxylase beta subunit K01572 - 4.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 557.0
HFD2_k127_8525404_5 3-hydroxyacyl-CoA dehydrogenase K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 550.0
HFD2_k127_8525404_6 Methionine synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 467.0
HFD2_k127_8525404_7 GDSL-like Lipase/Acylhydrolase K12686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 455.0
HFD2_k127_8525404_8 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 419.0
HFD2_k127_8525404_9 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002416 364.0
HFD2_k127_8550649_0 Binding-protein-dependent transport system inner membrane component K02011 - - 2.865e-268 837.0
HFD2_k127_8550649_1 ethanolamine utilization protein K04019 GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0030091,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009,GO:0071704,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 537.0
HFD2_k127_8550649_2 ATPases associated with a variety of cellular activities K02010 - 3.6.3.30 0.00000000000000000006775 105.0
HFD2_k127_8566655_0 X-Pro dipeptidyl-peptidase domain protein K06978 - - 1.707e-220 705.0
HFD2_k127_8566655_1 Amidohydrolase K10220 - 4.2.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 407.0
HFD2_k127_8566655_2 Cupin domain - - - 0.0000000000000000000000000000000000000009751 155.0
HFD2_k127_8566655_3 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.00000000000004541 84.0
HFD2_k127_8566655_4 Tripartite tricarboxylate transporter family receptor - - - 0.000000000804 61.0
HFD2_k127_8604164_0 nitrate nitrite transporter K02575 - - 4.707e-211 662.0
HFD2_k127_8604164_1 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 577.0
HFD2_k127_8604164_2 Major Facilitator Superfamily K02575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000427 320.0
HFD2_k127_8604164_3 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009081 270.0
HFD2_k127_8604164_4 Esterase-like activity of phytase - - - 0.000000000000000000000000000000000000000000000000000000002582 213.0
HFD2_k127_8604164_5 Hemerythrin HHE cation binding K07322 - - 0.000000000000000000000000000000000002402 145.0
HFD2_k127_8604164_6 Universal stress protein - - - 0.000000000000000000000000000000007901 132.0
HFD2_k127_8604164_7 Rubrerythrin - - - 0.0000000001054 74.0
HFD2_k127_8604164_9 cytochrome - - - 0.000001519 59.0
HFD2_k127_8657585_0 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007952 616.0
HFD2_k127_8657585_1 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 501.0
HFD2_k127_8657585_2 Methyl-transferase K18912 - 1.14.99.50 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 358.0
HFD2_k127_8657585_3 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 288.0
HFD2_k127_8657585_4 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000262 265.0
HFD2_k127_8657585_5 PFAM lipolytic protein G-D-S-L family K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000001861 224.0
HFD2_k127_8657585_6 Thioredoxin-like - - - 0.0000000000000000000009341 99.0
HFD2_k127_8675616_0 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005069 550.0
HFD2_k127_8675616_1 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 313.0
HFD2_k127_8675616_2 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001206 285.0
HFD2_k127_8675616_3 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000361 299.0
HFD2_k127_8710206_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1028.0
HFD2_k127_8710206_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.407e-313 971.0
HFD2_k127_8710206_10 Belongs to the SUA5 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001144 278.0
HFD2_k127_8710206_11 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002287 264.0
HFD2_k127_8710206_12 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003656 258.0
HFD2_k127_8710206_13 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000007606 218.0
HFD2_k127_8710206_14 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000000000000000000000009474 164.0
HFD2_k127_8710206_15 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000000836 130.0
HFD2_k127_8710206_16 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000000000006807 136.0
HFD2_k127_8710206_17 2 iron, 2 sulfur cluster binding K00207,K00219,K00317,K00528,K02293,K02823,K05368,K10797 - 1.16.1.3,1.18.1.2,1.19.1.1,1.3.1.2,1.3.1.31,1.3.1.34,1.3.5.5,1.5.1.41,1.5.8.1,1.5.8.2 0.0000000000000000000000000001352 119.0
HFD2_k127_8710206_2 Participates in both transcription termination and antitermination K02600 - - 1.958e-211 679.0
HFD2_k127_8710206_3 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 2.842e-206 669.0
HFD2_k127_8710206_4 D-amino acid dehydrogenase K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008244 494.0
HFD2_k127_8710206_5 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007452 351.0
HFD2_k127_8710206_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009211 346.0
HFD2_k127_8710206_7 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 320.0
HFD2_k127_8710206_8 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002866 284.0
HFD2_k127_8710206_9 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000002394 277.0
HFD2_k127_892645_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 1.58e-282 883.0
HFD2_k127_892645_1 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009658 444.0
HFD2_k127_892645_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 439.0
HFD2_k127_892645_3 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 404.0
HFD2_k127_892645_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000002958 107.0
HFD2_k127_896513_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001353 264.0
HFD2_k127_896513_1 metal-dependent hydrolase of the TIM-barrel fold K10221 - 3.1.1.57 0.0000000000000000000000000000000000000000000000000000000000000001657 231.0
HFD2_k127_896513_2 Cupin domain - - - 0.00000000000000000000000000000000000000000000000007595 183.0
HFD2_k127_896513_3 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.00000000000000002066 82.0
HFD2_k127_90438_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1266.0
HFD2_k127_90438_1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007051 507.0
HFD2_k127_90438_2 chorismate mutase K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 406.0
HFD2_k127_90438_3 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 399.0
HFD2_k127_90438_4 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000008974 232.0
HFD2_k127_919507_0 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 623.0
HFD2_k127_919507_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14392 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 516.0
HFD2_k127_919507_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 335.0
HFD2_k127_919507_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 345.0
HFD2_k127_919507_4 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 289.0
HFD2_k127_919507_5 import inner membrane translocase subunit Tim44 - - - 0.00000000000000000000000000000000000000000000000000000005543 207.0
HFD2_k127_919507_6 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase K06127 GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.201 0.000000000000000000000000000000000000277 160.0
HFD2_k127_919507_7 - - - - 0.0000000000000000000000000003269 130.0
HFD2_k127_919507_8 SCP-2 sterol transfer family K03690 - - 0.000000006421 67.0
HFD2_k127_919865_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 4.842e-208 675.0
HFD2_k127_919865_1 PFAM Rieske 2Fe-2S domain protein K18068 - 1.14.12.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 546.0
HFD2_k127_919865_10 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000788 242.0
HFD2_k127_919865_11 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000002195 233.0
HFD2_k127_919865_12 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.000000000000000000000000000000000000000000000000000002828 194.0
HFD2_k127_919865_13 Belongs to the TPP enzyme family K01576 - 4.1.1.7 0.00000000000000000000000000000000000000000000000000002617 210.0
HFD2_k127_919865_14 Protein of unknown function (DUF423) - - - 0.00000000000000000000000000000000000000000000173 167.0
HFD2_k127_919865_15 Cupin domain - - - 0.0000000000000000002014 91.0
HFD2_k127_919865_17 Helix-hairpin-helix motif K02237 - - 0.00000007383 58.0
HFD2_k127_919865_2 Belongs to the TPP enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 392.0
HFD2_k127_919865_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 391.0
HFD2_k127_919865_4 haloacid dehalogenase K01560 - 3.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 315.0
HFD2_k127_919865_5 abc transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001831 285.0
HFD2_k127_919865_6 Belongs to the UbiD family K16874 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001799 281.0
HFD2_k127_919865_7 amidohydrolase K14333 - 4.1.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000002863 274.0
HFD2_k127_919865_8 abc transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003865 276.0
HFD2_k127_919865_9 Haemolysin-III related K11068 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002808 255.0
HFD2_k127_92298_0 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00001,K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 478.0
HFD2_k127_92298_1 Aldehyde dehydrogenase K00128,K00130 - 1.2.1.3,1.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008026 439.0
HFD2_k127_92298_2 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 302.0
HFD2_k127_923932_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 7.652e-222 708.0
HFD2_k127_923932_1 COG0210 Superfamily I DNA and RNA helicases K03657 - 3.6.4.12 1.177e-220 726.0
HFD2_k127_923932_2 Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily K01919 - 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 619.0
HFD2_k127_923932_3 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000000000000000000000000000004377 194.0
HFD2_k127_923932_4 COG2513 PEP phosphonomutase and related enzymes - - - 0.00000000000000000000000000000000002767 154.0
HFD2_k127_923932_5 PFAM Uncharacterised protein family (UPF0150) - - - 0.000006811 58.0
HFD2_k127_972321_0 Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family K03455 - - 6.843e-207 663.0
HFD2_k127_972321_1 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006004 407.0
HFD2_k127_972321_2 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase K03270 - 3.1.3.45 0.000000000000000000000000000000000003242 140.0
HFD2_k127_972321_3 Prokaryotic N-terminal methylation motif - - - 0.00000000000004481 75.0