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Overview

ID MAG01694
Name HFD3_bin.38
Sample SMP0045
Taxonomy
Kingdom Archaea
Phylum Thermoproteota
Class Bathyarchaeia
Order Bathyarchaeales
Family Bathycorpusculaceae
Genus UBA11855
Species UBA11855 sp035297385
Assembly information
Completeness (%) 77.49
Contamination (%) 2.92
GC content (%) 40.0
N50 (bp) 5,636
Genome size (bp) 1,720,335

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1570

Gene name Description KEGG GOs EC E-value Score Sequence
HFD3_k127_1006155_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004298 356.0
HFD3_k127_1006155_1 Belongs to the SUI1 family K03113 - - 0.0000000000000000000000000000001784 127.0
HFD3_k127_1006155_2 PFAM Glycosyl transferase family 2 K21349 - 2.4.1.268 0.0000000000000000000000000002562 121.0
HFD3_k127_1006155_3 - - - - 0.0001727 48.0
HFD3_k127_1015351_0 Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000003491 266.0
HFD3_k127_1015351_1 Protein of unknown function (DUF2384) - - - 0.000000000000000000000006339 106.0
HFD3_k127_1015351_2 RES - - - 0.000000000001365 70.0
HFD3_k127_1026329_0 Domain of unknown function (DUF4162) K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006938 258.0
HFD3_k127_1026329_1 DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000001368 218.0
HFD3_k127_1026329_10 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.0000002704 56.0
HFD3_k127_1026329_11 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000007037 50.0
HFD3_k127_1026329_2 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.000000000000000000000000000000000000000000003402 168.0
HFD3_k127_1026329_3 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.0000000000000000000000000000000000001392 146.0
HFD3_k127_1026329_4 Belongs to the UPF0218 family K09735 - - 0.0000000000000000000000000000236 123.0
HFD3_k127_1026329_5 Fcf1 K07158 - - 0.000000000000000002941 90.0
HFD3_k127_1026329_6 - - - - 0.00000000000001898 78.0
HFD3_k127_1026329_7 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.000000000001993 68.0
HFD3_k127_1026329_8 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000001761 68.0
HFD3_k127_1026329_9 Transport permease protein K01992 - - 0.000000007406 66.0
HFD3_k127_1026817_0 PFAM Chaperonin Cpn60 TCP-1 K22447 - - 2.251e-197 629.0
HFD3_k127_1026817_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 381.0
HFD3_k127_1026817_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000005157 179.0
HFD3_k127_1026817_3 Thymidylate synthase K00560 - 2.1.1.45 0.000000000000000000000001463 112.0
HFD3_k127_1026817_4 acetyltransferase K03826 - - 0.0000001994 57.0
HFD3_k127_105471_0 - - - - 0.00000000000037 76.0
HFD3_k127_105471_1 PFAM CBS domain containing protein - - - 0.00002388 49.0
HFD3_k127_105471_2 peptidase S8 and S53, subtilisin, kexin, sedolisin K20754 - 3.4.21.111 0.0003446 50.0
HFD3_k127_1101156_0 PFAM Thiamine pyrophosphate K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 319.0
HFD3_k127_1101156_1 AAA-like domain K06915 - - 0.0000000000000000000000000000000000000001183 161.0
HFD3_k127_1101156_2 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000005005 136.0
HFD3_k127_1154841_0 Aldehyde ferredoxin K03738,K19515 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006386 448.0
HFD3_k127_1154841_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001309 276.0
HFD3_k127_1154841_10 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant K01091 - 3.1.3.18 0.00000000000000000007091 98.0
HFD3_k127_1154841_11 Major facilitator superfamily K07552 - - 0.0000000001506 73.0
HFD3_k127_1154841_12 Methyltransferase type 11 - - - 0.0000000006707 70.0
HFD3_k127_1154841_13 EamA-like transporter family - - - 0.000000001329 67.0
HFD3_k127_1154841_14 regulatory protein, arsR - - - 0.000000001932 63.0
HFD3_k127_1154841_15 transcriptional - - - 0.0000005273 63.0
HFD3_k127_1154841_16 EamA-like transporter family - - - 0.0002445 46.0
HFD3_k127_1154841_2 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000006553 251.0
HFD3_k127_1154841_3 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000007173 248.0
HFD3_k127_1154841_4 glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.00000000000000000000000000000000000000000000000000000336 193.0
HFD3_k127_1154841_5 Flavodoxin domain - - - 0.0000000000000000000000000000000000000000000000000001434 191.0
HFD3_k127_1154841_6 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000002307 173.0
HFD3_k127_1154841_7 TIGRFAM 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase K00004,K00008,K00060 - 1.1.1.103,1.1.1.14,1.1.1.303,1.1.1.4 0.000000000000000000000000000000000000000000001789 177.0
HFD3_k127_1154841_8 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.000000000000000000000000000000000000001312 153.0
HFD3_k127_1154841_9 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000003035 134.0
HFD3_k127_1170096_0 Aminotransferase class-III K00823,K03918,K20428 - 2.6.1.19,2.6.1.33,2.6.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008999 464.0
HFD3_k127_1170096_1 component I K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 457.0
HFD3_k127_1170096_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000433 366.0
HFD3_k127_1170096_3 Glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000001014 258.0
HFD3_k127_1170096_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000001105 201.0
HFD3_k127_1170096_5 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000007613 191.0
HFD3_k127_1170096_6 Functions by promoting the formation of the first peptide bond K03263 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000001322 153.0
HFD3_k127_1170096_7 Belongs to the TrpC family K01609 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 0.0000000000000000000000000000000000000009014 157.0
HFD3_k127_1170096_8 PIN domain of ribonuclease K07060 - - 0.000000000000000000000000004047 117.0
HFD3_k127_1174826_0 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005234 297.0
HFD3_k127_1174826_1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K02823 - - 0.000000000000000000000000000000000000000000000000000000000002312 218.0
HFD3_k127_1174826_2 Rieske 2Fe-2S K05710 - - 0.00000000000000002673 85.0
HFD3_k127_1174826_3 alginic acid biosynthetic process K12287 - - 0.00000000000004967 81.0
HFD3_k127_1174826_4 GCN5-related N-acetyl-transferase - - - 0.00000004278 58.0
HFD3_k127_1184911_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.202e-210 668.0
HFD3_k127_1184911_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 493.0
HFD3_k127_1184911_2 Helix-turn-helix domain K07731 - - 0.00000000000000000000000000000000000000000000000000000000000000001874 232.0
HFD3_k127_1184911_3 PFAM regulatory protein, MarR - - - 0.000001232 58.0
HFD3_k127_1184911_4 membrane - - - 0.0001872 49.0
HFD3_k127_1190955_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 481.0
HFD3_k127_1190955_1 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004049 370.0
HFD3_k127_1190955_2 Belongs to the histone deacetylase family. HD Type 1 subfamily K06067 - 3.5.1.98 0.00000009437 57.0
HFD3_k127_119859_0 PFAM BadF BadG BcrA BcrD ATPase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 371.0
HFD3_k127_119859_1 PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008538 301.0
HFD3_k127_119859_2 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003398 251.0
HFD3_k127_119859_3 4Fe-4S binding domain - - - 0.00000000000000000000004938 112.0
HFD3_k127_119859_4 4 iron, 4 sulfur cluster binding - - - 0.00000000000003107 74.0
HFD3_k127_119859_5 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.000007733 55.0
HFD3_k127_1217163_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004623 461.0
HFD3_k127_1217163_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 437.0
HFD3_k127_1217163_2 PFAM Thiamine pyrophosphate K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000663 203.0
HFD3_k127_1217163_3 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000004347 198.0
HFD3_k127_1217163_4 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.000000000000000000006683 96.0
HFD3_k127_1217929_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 402.0
HFD3_k127_1217929_1 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000000000000002643 192.0
HFD3_k127_1217929_2 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.00000000000000000000002128 104.0
HFD3_k127_1217929_3 - - - - 0.00000000000000004523 85.0
HFD3_k127_1217929_4 PFAM regulatory protein AsnC Lrp family - - - 0.00006615 51.0
HFD3_k127_1220963_0 Glycosyl transferase 4-like - - - 0.00000000000000000000000000000000000000000000000686 186.0
HFD3_k127_1220963_1 Glycosyl transferase 4-like - - - 0.000000000000000000004466 105.0
HFD3_k127_1226850_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 402.0
HFD3_k127_1226850_1 Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG) K07026 - 3.1.3.70 0.00000000000000000000000000000000000000000000000001297 189.0
HFD3_k127_1226850_2 Binds to the 23S rRNA K02876 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000008748 112.0
HFD3_k127_1226850_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000617 78.0
HFD3_k127_1226850_4 Alternative locus ID K13693 - 2.4.1.266 0.000001301 51.0
HFD3_k127_1235904_0 resolution of meiotic recombination intermediates - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005957 316.0
HFD3_k127_1235904_1 cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000085 286.0
HFD3_k127_1235904_2 - - - - 0.0000000003247 64.0
HFD3_k127_1235904_3 Acetyltransferase (GNAT) domain - - - 0.0006317 43.0
HFD3_k127_1251541_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 7.855e-305 970.0
HFD3_k127_1251541_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000001268 269.0
HFD3_k127_1251541_2 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000000004444 243.0
HFD3_k127_1251541_3 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000139 213.0
HFD3_k127_1251541_4 MazG nucleotide pyrophosphohydrolase domain - - - 0.00000000000000000000000000001254 120.0
HFD3_k127_1251541_5 Transcription elongation factor Elf1 like - - - 0.00000000002863 68.0
HFD3_k127_1251541_6 Sec61beta family - - - 0.0000000009289 61.0
HFD3_k127_1252402_0 Adenylate K01768 - 4.6.1.1 0.00000000000000000000000000000002508 147.0
HFD3_k127_1252402_1 Major facilitator Superfamily - - - 0.000000004262 68.0
HFD3_k127_1257289_0 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000122 271.0
HFD3_k127_1257289_1 Methyltransferase K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000001575 234.0
HFD3_k127_1257289_2 Domain of unknown function (DUF371) K09738 - - 0.000000000000000000000000000000002539 134.0
HFD3_k127_1257289_3 Acylphosphatase - - - 0.0000000000000000000000344 102.0
HFD3_k127_1257289_4 PFAM S-layer - - - 0.000000001077 60.0
HFD3_k127_1259198_0 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000001717 261.0
HFD3_k127_1264614_0 UDPglucose 4-epimerase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000001281 224.0
HFD3_k127_1264614_1 4Fe-4S single cluster domain K06937 - - 0.000000000000000000000000000000000000000000000000004003 188.0
HFD3_k127_1264614_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000000000000001779 123.0
HFD3_k127_1264614_3 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.0000000000000000000629 98.0
HFD3_k127_1264614_4 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000155 98.0
HFD3_k127_1285446_0 Catalase K03781 - 1.11.1.6 1.291e-279 872.0
HFD3_k127_1285446_1 TIGRFAM LPPG domain protein containing protein K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000007444 182.0
HFD3_k127_1285446_2 Ferric reductase like transmembrane component - - - 0.0000000000000000000002271 106.0
HFD3_k127_1285446_3 TOBE domain - - - 0.00000000000000000002786 91.0
HFD3_k127_1285446_4 Hemerythrin HHE cation binding domain - - - 0.00000000000000006076 86.0
HFD3_k127_1285446_5 phosphate transport K07220 - - 0.00000000000002716 81.0
HFD3_k127_1291577_0 TIGRFAM cation diffusion facilitator family transporter - - - 0.000000000000000000000000000000000000000000000000000000002989 207.0
HFD3_k127_1291577_1 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000005529 141.0
HFD3_k127_1291577_2 Sodium hydrogen exchanger K03455 - - 0.00000000000000000000001528 104.0
HFD3_k127_1291577_3 TIGRFAM cation diffusion facilitator family transporter - - - 0.000000000000273 70.0
HFD3_k127_1309700_0 DEAD DEAH box helicase domain protein K03724 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 297.0
HFD3_k127_1309700_1 TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001484 283.0
HFD3_k127_1309700_2 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000009579 205.0
HFD3_k127_1309700_3 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.0000000000000000000000000000004192 127.0
HFD3_k127_1309700_4 metal-sulfur cluster biosynthetic enzyme K02612 - - 0.000000009802 61.0
HFD3_k127_1316805_0 AAA ATPase domain - - - 0.0000000000000000001219 105.0
HFD3_k127_136805_0 PFAM tRNA synthetase, class II (D, K and N) K01893 - 6.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 455.0
HFD3_k127_136805_1 Oxidoreductase FAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001377 237.0
HFD3_k127_136805_2 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0006139,GO:0006396,GO:0006399,GO:0006464,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046483,GO:0051604,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000002351 68.0
HFD3_k127_136805_3 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000002296 60.0
HFD3_k127_136805_4 exosome subunit K07581 - - 0.0007843 43.0
HFD3_k127_1369376_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00262 - 1.4.1.4 4.008e-218 683.0
HFD3_k127_1369376_1 Transcriptional regulator K03718 - - 0.000000000000001626 83.0
HFD3_k127_1369376_2 helix_turn_helix ASNC type K03718 - - 0.000000000504 67.0
HFD3_k127_1369376_3 Protein of unknown function (DUF996) - - - 0.0007442 43.0
HFD3_k127_1400407_0 amino acid activation for nonribosomal peptide biosynthetic process K17713 - - 0.0006549 53.0
HFD3_k127_1408970_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01870 - 6.1.1.5 8.385e-253 799.0
HFD3_k127_148418_0 Heat shock 70 kDa protein K04043 - - 6.774e-249 782.0
HFD3_k127_148418_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001213 276.0
HFD3_k127_148418_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.000000000000000000000000004716 118.0
HFD3_k127_1489951_0 PFAM plasmid stabilization system K06218 - - 0.000000000000000001425 88.0
HFD3_k127_1498632_0 Pfam:DUF650 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 336.0
HFD3_k127_1498632_1 pyridoxamine 5'-phosphate K07005 - - 0.0000000000000000006438 91.0
HFD3_k127_1565901_0 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 393.0
HFD3_k127_1565901_1 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000442 376.0
HFD3_k127_1565901_2 ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - 0.00000000000000000000000000000000000000000000000000000000000001592 226.0
HFD3_k127_1565901_3 Protein of unknown function (DUF1638) - - - 0.00000000000000005899 89.0
HFD3_k127_1569323_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K13798 - 2.7.7.6 0.0 1329.0
HFD3_k127_1569323_1 Thiamine biosynthesis protein (ThiI) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001556 285.0
HFD3_k127_1569323_2 PFAM Glycosyl transferase family 2 K00786 - - 0.000000000000000000000000000000000000000000000000000000001956 214.0
HFD3_k127_1569323_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.00000000000000000000000000000002254 128.0
HFD3_k127_1569323_4 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000009328 109.0
HFD3_k127_1570508_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000501 213.0
HFD3_k127_1570508_1 aldo keto reductase K07079 - - 0.000000000000000000000008611 105.0
HFD3_k127_1570508_2 Part of a membrane complex involved in electron transport K03614 - - 0.0000000000000000005013 100.0
HFD3_k127_1570508_3 Part of a membrane complex involved in electron transport K03615 - - 0.000000003673 69.0
HFD3_k127_1579913_0 in RNase L inhibitor, RLI K06174 - - 8.636e-202 645.0
HFD3_k127_1579913_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009717 341.0
HFD3_k127_1581468_0 COG0455 ATPases involved in chromosome partitioning K03496,K03609 - - 0.0000000000000000000000000000000000000000007697 167.0
HFD3_k127_1581468_1 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000002472 133.0
HFD3_k127_1581468_2 Transcriptional regulator, TrmB - - - 0.000000000000000002551 89.0
HFD3_k127_1581468_3 Transcriptional regulator - - - 0.00007765 49.0
HFD3_k127_1583438_0 4-alpha-D-((1- 4)-alpha-D-glucano)trehalose trehalohydrolase K01236 - 3.2.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 569.0
HFD3_k127_1583438_1 glucose sorbosone K00117 - 1.1.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 430.0
HFD3_k127_1583438_2 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005743 278.0
HFD3_k127_1583438_3 Protein of unknown function DUF89 K09116 - - 0.000000000000000000000000000000000000000000000000000000003971 209.0
HFD3_k127_1583438_4 Glycogen debranching enzyme N terminal - - - 0.000000000000000000000000000000000000000006512 163.0
HFD3_k127_1583438_5 Glyoxalase-like domain K06996 - - 0.00000000000000000000000000000001721 129.0
HFD3_k127_1583438_6 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.000000000000000000007513 96.0
HFD3_k127_1583438_7 PFAM CBS domain containing protein - - - 0.0000000003538 73.0
HFD3_k127_1583438_8 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000007903 59.0
HFD3_k127_1587620_0 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000001032 176.0
HFD3_k127_1587620_1 Transport permease protein K01992 - - 0.0000009389 61.0
HFD3_k127_1589119_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005808 606.0
HFD3_k127_1589119_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.000000000000000000000000000000000000000188 157.0
HFD3_k127_1589119_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.000000000000000000000000000001801 123.0
HFD3_k127_1589119_3 PFAM UspA domain protein - - - 0.000000000000000000000000002159 116.0
HFD3_k127_1589119_4 ATPases associated with a variety of cellular activities K01990,K11050 - - 0.000000000000000004262 85.0
HFD3_k127_1589119_5 ATP synthase subunit C K02124 - - 0.00000000003637 68.0
HFD3_k127_1589119_6 Transcriptional regulator PadR-like family - - - 0.0003691 48.0
HFD3_k127_1606360_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000000000000000001995 207.0
HFD3_k127_1606360_2 Fibronectin-binding A domain protein - - - 0.0000000000000000000000000003377 120.0
HFD3_k127_1606360_3 - - - - 0.00001567 53.0
HFD3_k127_1618092_1 PFAM Conserved TM helix repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000005227 242.0
HFD3_k127_1618092_2 - - - - 0.00000000000000000000000000000000000000000000000000000004664 205.0
HFD3_k127_1618092_3 Secreted surface protein with fasciclin-like repeats - - - 0.00000000000000000000000000000000001003 149.0
HFD3_k127_1620881_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000103 206.0
HFD3_k127_1620881_1 Predicted membrane protein (DUF2079) - - - 0.0000000000000000000000000000776 132.0
HFD3_k127_1620881_2 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000002626 118.0
HFD3_k127_1630618_0 Pfam:Methyltransf_26 K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000002828 173.0
HFD3_k127_1630618_1 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000000000000000000001992 162.0
HFD3_k127_1630618_2 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000001473 123.0
HFD3_k127_1630618_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000001593 55.0
HFD3_k127_1651191_0 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006315 458.0
HFD3_k127_1651191_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008768 319.0
HFD3_k127_1651191_2 Suf system fes assembly protein K04488,K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000004458 200.0
HFD3_k127_1651191_3 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000002353 154.0
HFD3_k127_1651191_4 - - - - 0.00000000000000000000000000000000000000003657 170.0
HFD3_k127_1651191_5 - - - - 0.0000000000000000000000001964 121.0
HFD3_k127_165509_0 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 2.846e-224 706.0
HFD3_k127_165509_1 ABC-type multidrug transport system, ATPase component K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004131 418.0
HFD3_k127_165509_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000315 351.0
HFD3_k127_165509_3 NAD(P)H dehydrogenase (quinone) activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007494 271.0
HFD3_k127_165509_4 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000008772 216.0
HFD3_k127_165509_5 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.000000000000000000000000000000000000000000000000000000001139 215.0
HFD3_k127_165509_6 PFAM Peptidase family M20 M25 M40 - - - 0.00000000000000000000000006664 116.0
HFD3_k127_165509_7 Bacterio-opsin activator HTH K06930 - - 0.00000000000000001224 91.0
HFD3_k127_1670071_0 COG1520 FOG WD40-like repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 335.0
HFD3_k127_1670071_1 RimK-like ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000005346 181.0
HFD3_k127_1670071_2 RimK-like ATPgrasp N-terminal domain - - - 0.00000000000000000000000000000000007994 141.0
HFD3_k127_1673967_0 H4MPT-linked C1 transfer pathway protein K07072 - 2.5.1.131 0.00000000000000000000000000000000000000000000000000000000006639 214.0
HFD3_k127_1673967_1 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.0000000000000000000000000000000000000005318 154.0
HFD3_k127_1673967_2 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000003859 153.0
HFD3_k127_1673967_3 PFAM Aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.0000000000000000000000000000000004865 140.0
HFD3_k127_1673967_4 - - - - 0.0006215 44.0
HFD3_k127_1680341_0 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000002938 204.0
HFD3_k127_1680341_1 PFAM type II secretion system protein E K07332 - - 0.00000000004992 67.0
HFD3_k127_1700778_0 TIM barrel K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000002341 224.0
HFD3_k127_1700778_1 PFAM Cobalt transport protein K16785 - - 0.0000000000000000000000000000000004173 141.0
HFD3_k127_1700778_2 dextransucrase activity K01729,K02280,K03975,K07126,K08600,K09942,K13963,K21012 - 3.4.22.70,4.2.2.3 0.0000228 55.0
HFD3_k127_1701662_0 TGS domain K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007178 327.0
HFD3_k127_1701662_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000003795 245.0
HFD3_k127_1701662_2 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000004581 219.0
HFD3_k127_1701662_3 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.00000000000000006908 83.0
HFD3_k127_1701662_4 Histidine kinase - - - 0.000000000003149 67.0
HFD3_k127_17085_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003814 273.0
HFD3_k127_17085_1 Flavin reductase like domain - - - 0.00000000000000000000000000000008238 128.0
HFD3_k127_17085_2 PFAM flavin reductase domain protein, FMN-binding - - - 0.0000000000000001803 81.0
HFD3_k127_17085_3 Radical SAM - - - 0.0000003775 54.0
HFD3_k127_1713810_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000007177 62.0
HFD3_k127_1721449_0 MGS-like domain K01955 - 6.3.5.5 0.0 1038.0
HFD3_k127_1721449_1 PFAM Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 353.0
HFD3_k127_1721449_2 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000003624 219.0
HFD3_k127_1721449_3 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.00000000001337 65.0
HFD3_k127_1728877_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 551.0
HFD3_k127_1728877_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006934 415.0
HFD3_k127_1728877_10 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000003659 244.0
HFD3_k127_1728877_11 Chorismate mutase type II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000005107 233.0
HFD3_k127_1728877_12 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 GO:0003674,GO:0003824,GO:0003861,GO:0016829,GO:0016835,GO:0016836 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000008621 216.0
HFD3_k127_1728877_13 Shikimate kinase K00891 - 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000003792 216.0
HFD3_k127_1728877_14 dehydratase shikimate K13832 GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615 1.1.1.25,4.2.1.10 0.00000000000000000000000000000000003706 142.0
HFD3_k127_1728877_15 T-protein K04517,K14187 GO:0000166,GO:0003674,GO:0003824,GO:0004106,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,5.4.99.5 0.0000003915 55.0
HFD3_k127_1728877_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 417.0
HFD3_k127_1728877_3 Isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006687 401.0
HFD3_k127_1728877_4 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002125 324.0
HFD3_k127_1728877_5 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 311.0
HFD3_k127_1728877_6 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006675 309.0
HFD3_k127_1728877_7 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005654 284.0
HFD3_k127_1728877_8 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003222 280.0
HFD3_k127_1728877_9 Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000385 253.0
HFD3_k127_1738785_0 sh3 domain protein - - - 0.000002519 61.0
HFD3_k127_1762933_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 331.0
HFD3_k127_1762933_1 TIGRFAM excinuclease ABC, C subunit K03703 - - 0.00000000000000000000000000000000000000000000000008039 182.0
HFD3_k127_1762933_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000001329 144.0
HFD3_k127_1762933_3 - - - - 0.000000000000000006845 93.0
HFD3_k127_1762933_4 Xylose isomerase-like TIM barrel - - - 0.0001518 52.0
HFD3_k127_1764449_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008713 283.0
HFD3_k127_1764449_1 PFAM CoA-binding domain protein K06929 - - 0.00000000000000000000000000000000000006516 147.0
HFD3_k127_1764449_2 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000001563 115.0
HFD3_k127_1764449_3 flavodoxin nitric oxide synthase K22405 - 1.6.3.4 0.00000000000000000003638 97.0
HFD3_k127_1764449_4 membrane - - - 0.0000000001332 65.0
HFD3_k127_1764449_5 Uncharacterized protein family UPF0016 - - - 0.00006551 49.0
HFD3_k127_1772261_0 regulatory protein, arsR - - - 0.000006251 51.0
HFD3_k127_1806925_0 S-layer homology domain - - - 0.00000000000000000000000000000000000000000000000000002554 212.0
HFD3_k127_1811140_0 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005179 405.0
HFD3_k127_1811140_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004145 288.0
HFD3_k127_1811140_2 Belongs to the precorrin methyltransferase family K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.000000000000000000000000000000000000000000000000000000000000000000000001189 253.0
HFD3_k127_1811140_3 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.00000000000000000000000000000000000000000000000000007008 196.0
HFD3_k127_1811140_4 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.0000000000000000000000000000000000002077 151.0
HFD3_k127_1811140_5 synthase K02304 - 1.3.1.76,4.99.1.4 0.0000000000000000002604 92.0
HFD3_k127_1827442_0 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 315.0
HFD3_k127_1827442_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 300.0
HFD3_k127_1827442_2 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 GO:0000460,GO:0000470,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030684,GO:0030687,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042273,GO:0043021,GO:0043023,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1902626,GO:1990904 - 0.000000000000000000000000000000000000000000002069 173.0
HFD3_k127_1827442_3 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.0000000000000007758 83.0
HFD3_k127_1827442_4 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.000000000000001567 81.0
HFD3_k127_1827442_5 rRNA binding K02944 - - 0.000000000001625 69.0
HFD3_k127_1830378_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002941 297.0
HFD3_k127_1882769_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000595 338.0
HFD3_k127_1882769_1 Rubredoxin-type Fe(Cys)4 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003065 282.0
HFD3_k127_1882769_10 Bacterial transcription activator, effector binding domain - - - 0.0000000000000000000006194 97.0
HFD3_k127_1882769_11 helix_turn_helix ASNC type - - - 0.0000000000000009291 84.0
HFD3_k127_1882769_2 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001631 280.0
HFD3_k127_1882769_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000676 205.0
HFD3_k127_1882769_4 formamidopyrimidine-DNA glycosylase K05522 - 4.2.99.18 0.000000000000000000000000000000000000000000009422 172.0
HFD3_k127_1882769_5 COGs COG2335 Secreted and surface protein containing fasciclin-like repeats - - - 0.00000000000000000000000000000000000000000001911 165.0
HFD3_k127_1882769_6 Zinc transporter K07238 - - 0.000000000000000000000000000000000000000003073 165.0
HFD3_k127_1882769_7 ABC-type multidrug transport system, permease component K01992 - - 0.0000000000000000000000000000000000001743 151.0
HFD3_k127_1882769_8 SOUL heme-binding protein - - - 0.00000000000000000000000000000000006432 141.0
HFD3_k127_1882769_9 Protein of unknown function (DUF1722) - - - 0.000000000000000000000000000007955 121.0
HFD3_k127_1906020_0 - - - - 0.00000000000000000000000000000000000000000000000007698 182.0
HFD3_k127_1906020_1 Leucyl aminopeptidase K19701 - 3.4.11.10,3.4.11.6 0.000000000000791 78.0
HFD3_k127_1923671_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000001994 120.0
HFD3_k127_1923671_1 COGs COG4743 membrane protein - - - 0.00000000000000003236 88.0
HFD3_k127_1923671_2 - - - - 0.000000009872 66.0
HFD3_k127_1923671_3 PKD domain containing protein - - - 0.00006495 53.0
HFD3_k127_1953251_0 by modhmm K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000002419 201.0
HFD3_k127_1953251_1 S-layer homology domain - - - 0.00000000000002426 87.0
HFD3_k127_1953251_2 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738,K01883,K12339 - 2.5.1.47,6.1.1.16 0.0002543 44.0
HFD3_k127_1999316_0 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.000000000001784 78.0
HFD3_k127_1999316_1 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000002478 64.0
HFD3_k127_20132_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 4.99e-286 900.0
HFD3_k127_20132_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002138 541.0
HFD3_k127_20132_10 PHP domain K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000167 169.0
HFD3_k127_20132_11 Belongs to the universal ribosomal protein uL16 family K02866 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000003726 154.0
HFD3_k127_20132_12 TrkA-C domain - - - 0.0000000000000000000000000000000000000005218 155.0
HFD3_k127_20132_13 SMART Elongator protein 3 MiaB NifB K22227 - - 0.0000000000000000000000000000000000000007976 150.0
HFD3_k127_20132_14 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.00000000000000000000000000000000000279 151.0
HFD3_k127_20132_15 PhoU domain - - - 0.00000000000000000000000000000000004567 141.0
HFD3_k127_20132_16 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.0000000000000000000000000000000003493 138.0
HFD3_k127_20132_17 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000001102 102.0
HFD3_k127_20132_18 Ribonuclease III - - - 0.0000000000000002251 84.0
HFD3_k127_20132_19 HTH DNA binding domain - - - 0.000000001171 64.0
HFD3_k127_20132_2 AAA domain K07028 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 331.0
HFD3_k127_20132_20 AAA domain K07028 - - 0.000000001615 66.0
HFD3_k127_20132_21 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.0000000179 59.0
HFD3_k127_20132_22 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.000007319 55.0
HFD3_k127_20132_3 Diphthamide K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000002581 258.0
HFD3_k127_20132_4 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000442 246.0
HFD3_k127_20132_5 MgtE integral membrane K07244 - - 0.00000000000000000000000000000000000000000000000000000000000002122 229.0
HFD3_k127_20132_6 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000000000001029 192.0
HFD3_k127_20132_7 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006272,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0022616,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0043170,GO:0043626,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0044796,GO:0046483,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000003293 193.0
HFD3_k127_20132_8 Putative RNA methylase family UPF0020 - - - 0.000000000000000000000000000000000000000000004986 179.0
HFD3_k127_20132_9 Methyltransferase K07579 - - 0.00000000000000000000000000000000000000000000981 171.0
HFD3_k127_2015807_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 407.0
HFD3_k127_2015807_1 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 397.0
HFD3_k127_2015807_10 F420-0:Gamma-glutamyl ligase - - - 0.0000000000000000000000000000000000000000000007552 177.0
HFD3_k127_2015807_11 belongs to the PRA-CH family K01496,K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000002667 157.0
HFD3_k127_2015807_12 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate K02437 GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 - 0.000000000000000000000000000000000194 136.0
HFD3_k127_2015807_13 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.000000000000000000003294 98.0
HFD3_k127_2015807_14 - - - - 0.0000000002628 67.0
HFD3_k127_2015807_15 - - - - 0.0000179 53.0
HFD3_k127_2015807_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 376.0
HFD3_k127_2015807_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009581 336.0
HFD3_k127_2015807_4 4Fe-4S single cluster domain K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 322.0
HFD3_k127_2015807_5 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000001093 232.0
HFD3_k127_2015807_6 imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000006833 207.0
HFD3_k127_2015807_7 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000001784 188.0
HFD3_k127_2015807_8 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000003444 188.0
HFD3_k127_2015807_9 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K17870 - 1.6.3.3 0.0000000000000000000000000000000000000000000000008364 181.0
HFD3_k127_207305_0 PFAM Oxidoreductase K18855 - 1.1.1.374 0.0000000000000000000000000000000000000000000000000000000000000000000006992 248.0
HFD3_k127_207305_1 Met-10+ like-protein K15429 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000001284 231.0
HFD3_k127_207305_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000451 163.0
HFD3_k127_207305_3 Trm112p-like protein - - - 0.0000000000000000000000003577 107.0
HFD3_k127_207305_4 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000003867 113.0
HFD3_k127_207305_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.0000003356 53.0
HFD3_k127_207305_6 - - - - 0.000005756 52.0
HFD3_k127_2090738_0 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 335.0
HFD3_k127_2090738_1 Membrane protein of 12 TMs K01992,K07087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001372 296.0
HFD3_k127_2090738_2 amino acid K03294 - - 0.0000000000005985 74.0
HFD3_k127_2090738_3 Nitrous oxide-stimulated promoter - - - 0.00001929 46.0
HFD3_k127_2099752_0 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007978 467.0
HFD3_k127_2100300_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000492 295.0
HFD3_k127_2100300_1 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008423 256.0
HFD3_k127_2100300_2 - - - - 0.00000000000000000000000000000000000000000000000000000001338 206.0
HFD3_k127_2100300_3 Alpha-ribazole transporter - - - 0.00000000000001166 78.0
HFD3_k127_2106353_0 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.0 1040.0
HFD3_k127_2106353_1 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006251 317.0
HFD3_k127_2106353_2 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004714 280.0
HFD3_k127_2106353_3 OsmC-like protein - - - 0.0000000000000000000000000000007552 126.0
HFD3_k127_2106353_4 nitrogen fixation - - - 0.000000000000000000005414 96.0
HFD3_k127_2106353_5 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.00000000000000001088 88.0
HFD3_k127_2111309_0 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 312.0
HFD3_k127_2111309_1 SMART zinc finger, RanBP2-type - - - 0.0000000000000000000000000000000000000000000000000004993 196.0
HFD3_k127_2111309_2 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity K00549 - 2.1.1.14 0.000000000000000005258 87.0
HFD3_k127_2111309_3 Membrane-bound serine protease (ClpP class) K07403 - - 0.00000001333 61.0
HFD3_k127_2111309_4 - - - - 0.00004502 56.0
HFD3_k127_2111309_5 - - - - 0.0004327 49.0
HFD3_k127_2111327_0 Pyridoxal-phosphate dependent enzyme K01738,K12339 - 2.5.1.47 0.000000000000000000000000000000000000000000000000006658 186.0
HFD3_k127_2111327_1 Histidine kinase-like ATPases - - - 0.00000000000000000000000000002866 127.0
HFD3_k127_2111327_2 Histidine kinase - - - 0.000000005857 58.0
HFD3_k127_211784_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009564 292.0
HFD3_k127_2133232_0 Proteasome endopeptidase complex K03432 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000002048 219.0
HFD3_k127_2137955_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 404.0
HFD3_k127_2137955_1 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000003655 188.0
HFD3_k127_2137955_2 RimK-like ATP-grasp domain - - - 0.000000000000000000000001384 105.0
HFD3_k127_2148142_0 Thymidylate synthase K00560 - 2.1.1.45 0.0000000000002599 75.0
HFD3_k127_2148142_1 acetyltransferase K03826 - - 0.0000001064 58.0
HFD3_k127_2190345_0 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000001841 212.0
HFD3_k127_2190345_1 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.000000000000000000000005013 113.0
HFD3_k127_2190345_2 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.00000003915 64.0
HFD3_k127_219640_0 Histidine kinase-like ATPases - - - 0.0000000000000000000000003837 118.0
HFD3_k127_219640_1 response regulator, receiver K07669 - - 0.0000000000000000000000004708 109.0
HFD3_k127_2213899_0 Hydroxymethylglutaryl-CoA reductase, degradative K00054 - 1.1.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 514.0
HFD3_k127_2213899_1 helicase superfamily c-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 466.0
HFD3_k127_2213899_2 Protein of unknown function (DUF790) K09744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 320.0
HFD3_k127_2213899_3 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002423 256.0
HFD3_k127_2213899_4 Belongs to the UPF0200 family - - - 0.0000000000000000000000000000000000000000009308 163.0
HFD3_k127_2213899_5 Belongs to the UPF0201 family K09736 - - 0.0000000000000000000000000005328 117.0
HFD3_k127_2213899_6 PFAM NifU-like domain - - - 0.000000000000000000006194 94.0
HFD3_k127_2213899_7 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000006944 61.0
HFD3_k127_2216730_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005312 440.0
HFD3_k127_2216730_1 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.00000000000000000000000000000000000000000573 160.0
HFD3_k127_2216730_2 LysE type translocator - - - 0.000000000000000000000000000000000000002404 154.0
HFD3_k127_2216730_3 Nicotinamidase K08281 - 3.5.1.19 0.000000000476 63.0
HFD3_k127_2216730_4 PFAM regulatory protein AsnC Lrp family - - - 0.000000009988 59.0
HFD3_k127_2232748_0 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000006686 152.0
HFD3_k127_2232748_1 - K09932 - - 0.00000000000000000000000000000008635 126.0
HFD3_k127_2232748_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000001686 86.0
HFD3_k127_2232748_3 Protein of unknown function, DUF488 - - - 0.000000000000009866 75.0
HFD3_k127_2232748_4 Cation efflux family - - - 0.000000000004243 68.0
HFD3_k127_2234152_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006393 408.0
HFD3_k127_2234152_1 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 313.0
HFD3_k127_2234152_2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000000000000000000835 114.0
HFD3_k127_224601_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008814 372.0
HFD3_k127_224601_1 Glutamine amidotransferases class-II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 323.0
HFD3_k127_224601_2 4Fe-4S ferredoxin iron-sulfur binding domain protein K00196 - - 0.0000000000000000000000000000000000000000000000000000000007404 205.0
HFD3_k127_224601_3 Conserved region in glutamate synthase - - - 0.000000000000008248 75.0
HFD3_k127_2246997_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 573.0
HFD3_k127_2246997_1 Major Facilitator Superfamily K08223 - - 0.00000000000000000000000004758 121.0
HFD3_k127_2261929_0 PFAM Glycosyl transferase, group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 533.0
HFD3_k127_2261929_1 Phosphofructokinase K00850 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 422.0
HFD3_k127_2261929_2 Zn-dependent protease with chaperone function K03799 - - 0.00000000000000000000000000000000004545 142.0
HFD3_k127_2261929_3 CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000000000000339 119.0
HFD3_k127_22684_0 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000000000000000000000001513 173.0
HFD3_k127_22684_1 InterPro IPR014922 - - - 0.00000000000000000000000000000000000000000003284 164.0
HFD3_k127_22684_2 3-demethylubiquinone-9 3-methyltransferase - - - 0.000000001974 59.0
HFD3_k127_2315298_0 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000008325 166.0
HFD3_k127_2315298_1 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000001173 155.0
HFD3_k127_2389194_0 PFAM peptidase U62 modulator of DNA gyrase K03568 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0016787,GO:0019538,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 426.0
HFD3_k127_2389194_1 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005342 266.0
HFD3_k127_2389194_2 DNA helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000391 158.0
HFD3_k127_2389194_3 Protein of unknown function (DUF421) - - - 0.00000000000000000000000000000000000004351 152.0
HFD3_k127_2389194_4 Hemerythrin HHE cation binding K07322 - - 0.00000000000000000000000005671 112.0
HFD3_k127_2389194_5 Belongs to the UPF0337 (CsbD) family - - - 0.0001616 46.0
HFD3_k127_239086_0 Aminotransferase class-III K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000001096 173.0
HFD3_k127_239086_1 Predicted membrane protein (DUF2070) K08979 - - 0.0000000000000000000000000000000000000000000002696 188.0
HFD3_k127_2399994_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 8.438e-243 766.0
HFD3_k127_2399994_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 1.114e-227 719.0
HFD3_k127_2428545_0 transcriptional - - - 0.000000002139 63.0
HFD3_k127_2428545_1 Transcriptional regulator, TrmB - - - 0.0000001357 64.0
HFD3_k127_2428545_2 CHY zinc finger K16276 GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009057,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010498,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0019941,GO:0030003,GO:0030163,GO:0031667,GO:0031668,GO:0031669,GO:0032446,GO:0033554,GO:0036211,GO:0042592,GO:0042594,GO:0043161,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051603,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0061630,GO:0061659,GO:0065007,GO:0065008,GO:0070647,GO:0071496,GO:0071704,GO:0098771,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00001349 55.0
HFD3_k127_2428545_3 Transcriptional regulator, TrmB - - - 0.0007936 44.0
HFD3_k127_2433063_0 Aspartate carbamoyltransferase K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000318 381.0
HFD3_k127_2433063_1 Threonine aldolase K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 352.0
HFD3_k127_2433063_2 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000003223 265.0
HFD3_k127_245857_0 C-terminal four TMM region of protein-O-mannosyltransferase - - - 0.00000000000000000000000000000000000000000006558 173.0
HFD3_k127_245857_1 TIR domain - - - 0.000000000000000000000000000143 124.0
HFD3_k127_245857_2 type I restriction modification DNA specificity domain K01154 - 3.1.21.3 0.0000000002249 63.0
HFD3_k127_245857_3 Type I restriction modification DNA specificity domain K01154 - 3.1.21.3 0.00000000172 60.0
HFD3_k127_2463157_0 flavodoxin nitric oxide synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 444.0
HFD3_k127_2463157_1 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000003539 237.0
HFD3_k127_2463157_2 diphthine-ammonia ligase activity K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000001605 188.0
HFD3_k127_2463157_3 PFAM Phosphatidylglycerophosphatase A - - - 0.000000000000000000000000000000003992 134.0
HFD3_k127_2463157_4 Belongs to the UPF0284 family - - - 0.000000000000004226 78.0
HFD3_k127_2463157_6 - - - - 0.000000000002538 68.0
HFD3_k127_2493052_0 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 304.0
HFD3_k127_2493052_1 amine dehydrogenase activity - - - 0.00000000000000000000000000002346 128.0
HFD3_k127_2493052_2 toxin-antitoxin pair type II binding - - - 0.000000000000000001621 87.0
HFD3_k127_2504755_0 GTPase of K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 432.0
HFD3_k127_2504755_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000526 370.0
HFD3_k127_2504755_2 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 290.0
HFD3_k127_2504755_3 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000001328 234.0
HFD3_k127_2504755_4 Belongs to the UPF0282 family K07022 - - 0.0000000000000000000000000000000000000000000000000000000000000004494 231.0
HFD3_k127_2504755_5 O-methyltransferase - - - 0.000000000000000000000006197 108.0
HFD3_k127_2504755_6 COG1522 Transcriptional regulators - - - 0.00000000000000000001793 92.0
HFD3_k127_251167_0 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.0000000000000000000000000000001348 138.0
HFD3_k127_251167_1 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.000000000003371 79.0
HFD3_k127_2525646_0 DNA methylase K00590 - 2.1.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 402.0
HFD3_k127_2525646_1 4Fe-4S binding domain - - - 0.000000000000000000000000000002769 124.0
HFD3_k127_2525646_2 mRNA catabolic process - - - 0.0000001731 55.0
HFD3_k127_2545708_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K17870 - 1.6.3.3 0.00000000000000000000000000000001678 130.0
HFD3_k127_2545708_1 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000003379 72.0
HFD3_k127_2545799_0 Belongs to the UPF0219 family K01641 - 2.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008858 304.0
HFD3_k127_2545799_1 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000004674 152.0
HFD3_k127_2545799_2 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.000000000000000000007484 94.0
HFD3_k127_2550086_0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 321.0
HFD3_k127_2550086_1 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000009588 229.0
HFD3_k127_2550086_2 mevalonate kinase activity K00869,K15633 GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005829,GO:0006066,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006694,GO:0006695,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016126,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653 2.7.1.36,5.4.2.12 0.0000000000000000000000000000000000000000000000000000000001202 215.0
HFD3_k127_2550086_3 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000005885 168.0
HFD3_k127_2550086_4 Domain of unknown function (DUF4287) - - - 0.00000000004185 66.0
HFD3_k127_2551411_0 PFAM ABC transporter related K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007988 334.0
HFD3_k127_2551411_1 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003102 271.0
HFD3_k127_2551411_2 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000000000000000000000004762 142.0
HFD3_k127_2604000_0 Collagen triple helix repeat (20 copies) - - - 0.000000000003013 76.0
HFD3_k127_2671527_0 DEAD H associated K03724 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 475.0
HFD3_k127_2671527_1 Spore germination protein K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002541 263.0
HFD3_k127_2671527_2 DNA alkylation repair enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000004562 227.0
HFD3_k127_2671527_3 transcriptional - - - 0.0000000002981 70.0
HFD3_k127_2678807_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 309.0
HFD3_k127_2678807_1 Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position K01271 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000006613 263.0
HFD3_k127_2678807_2 Transglutaminase/protease-like homologues K01456 GO:0000224,GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006515,GO:0006516,GO:0006517,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009100,GO:0009636,GO:0009719,GO:0009725,GO:0009751,GO:0009987,GO:0010033,GO:0010035,GO:0010188,GO:0010193,GO:0014070,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0030163,GO:0036211,GO:0042221,GO:0042493,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051603,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1901700 3.5.1.52 0.0000006183 58.0
HFD3_k127_2697763_0 electron transfer activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007268 564.0
HFD3_k127_2697763_1 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 382.0
HFD3_k127_2697763_2 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000000000000000000000000177 219.0
HFD3_k127_2697763_3 c-type cytochrome biogenesis protein CcmF K02198 - - 0.00000000000000000000000000000000000000000000000001114 202.0
HFD3_k127_2697763_4 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000004225 139.0
HFD3_k127_2708843_0 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005145 282.0
HFD3_k127_2708843_1 PFAM Threonyl alanyl tRNA synthetase, SAD K07050 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000001365 260.0
HFD3_k127_2708843_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000000000000000000000000000000001027 194.0
HFD3_k127_2708843_3 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000723 186.0
HFD3_k127_2708843_4 Protein of unknown function (DUF2400) - - - 0.000001887 59.0
HFD3_k127_2742868_0 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006398 268.0
HFD3_k127_2742868_1 ATPases associated with a variety of cellular activities K09817 - - 0.00000000000000000000000000000000000000000000000000000000002192 213.0
HFD3_k127_2742868_2 ABC 3 transport family K19976 - - 0.000000000000000000000002235 113.0
HFD3_k127_2742868_3 PFAM NUDIX hydrolase K03574 - 3.6.1.55 0.00000000000000000003353 95.0
HFD3_k127_280980_0 Protein of unknown function (DUF1385) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002181 246.0
HFD3_k127_280980_1 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.0000000203 56.0
HFD3_k127_280980_2 PDGLE domain K02009 - - 0.0000004588 55.0
HFD3_k127_280980_3 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.00008879 48.0
HFD3_k127_2856373_0 malic enzyme K00027,K00029 - 1.1.1.38,1.1.1.40 1.433e-196 623.0
HFD3_k127_2856373_1 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 553.0
HFD3_k127_2856373_2 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000000004708 109.0
HFD3_k127_2856373_3 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K03658,K07466 - 3.6.4.12 0.000000000000000000000012 107.0
HFD3_k127_2856373_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000002485 67.0
HFD3_k127_2858775_0 Maltooligosyl trehalose synthase K06044 - 5.4.99.15 1.747e-212 685.0
HFD3_k127_2858775_1 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 515.0
HFD3_k127_2858775_2 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000029 230.0
HFD3_k127_2858775_3 COG NOG04001 non supervised orthologous group K15923 - 3.2.1.51 0.000000000000000000000000000000000000001044 155.0
HFD3_k127_2858775_4 PFAM ABC transporter related K01996 - - 0.00000000000000000000000009439 108.0
HFD3_k127_2858775_5 ACT domain - - - 0.00000000000000000000001446 106.0
HFD3_k127_2858775_6 PFAM Cupin - - - 0.00000000000000000000002234 105.0
HFD3_k127_2887681_0 COG1022 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 7.714e-240 759.0
HFD3_k127_2900018_0 metallopeptidase activity - - - 0.000003938 55.0
HFD3_k127_2900018_1 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) K07069 - - 0.00007671 46.0
HFD3_k127_2962203_0 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000001509 168.0
HFD3_k127_2962203_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000005845 152.0
HFD3_k127_2962203_2 -acetyltransferase K17840 - 2.3.1.59 0.0000000000002403 80.0
HFD3_k127_2989485_0 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000001743 168.0
HFD3_k127_2989485_1 - K00960 - 2.7.7.6 0.00000001197 58.0
HFD3_k127_2989485_2 lysine biosynthetic process via aminoadipic acid K05826 - - 0.000001627 52.0
HFD3_k127_2989485_3 TIGRFAM bacteriochlorophyll chlorophyll synthetase K04040 - 2.5.1.133,2.5.1.62 0.0009086 50.0
HFD3_k127_2990533_0 PFAM TCP-1 cpn60 chaperonin family K22447 - - 1.549e-204 651.0
HFD3_k127_2990533_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008568 591.0
HFD3_k127_2990533_2 PFAM ATP-NAD AcoX kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 356.0
HFD3_k127_2990533_3 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000002031 198.0
HFD3_k127_2990533_4 Mut7-C RNAse domain K09122 - - 0.000000000000000000000000000000000002569 143.0
HFD3_k127_2990533_5 regulator of amino acid metabolism K07103 - - 0.00000000000000000000000000001309 124.0
HFD3_k127_2990533_6 Cyclophilin-like K09143 - - 0.0000000000000000000001574 103.0
HFD3_k127_2990533_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03014,K03055 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000591 94.0
HFD3_k127_2995614_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 309.0
HFD3_k127_2995614_1 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.0000000000000000000000000000000000000000000000000000000003021 208.0
HFD3_k127_2995614_2 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.0000000000000000000000000000000000000005017 154.0
HFD3_k127_2995614_3 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000000000000000000000000615 142.0
HFD3_k127_2995614_4 Uncharacterized protein conserved in archaea (DUF2110) - - - 0.00000000000000000000000000815 118.0
HFD3_k127_2995614_5 Helix-turn-helix XRE-family like proteins K03627 - - 0.00000000000000000009591 96.0
HFD3_k127_2995614_6 PUA domain containing protein K07398 - - 0.00000000000000004121 86.0
HFD3_k127_3008680_0 dolichyl monophosphate biosynthetic process K18678 - 2.7.1.182 0.0000000000000000000000000000000000000000000000000005452 193.0
HFD3_k127_31043_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007314 335.0
HFD3_k127_31043_1 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000008248 134.0
HFD3_k127_31043_2 A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products K03552 - 3.1.22.4 0.000001619 54.0
HFD3_k127_3154192_0 Ntpase (Nacht family) - - - 0.0000000000002939 83.0
HFD3_k127_3263830_0 Alpha amylase K01208 - 3.2.1.133,3.2.1.135,3.2.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 501.0
HFD3_k127_3263830_1 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000001009 184.0
HFD3_k127_3263830_2 Domain of unknown function (DUF1724) - - - 0.0000000000000000000000004436 111.0
HFD3_k127_3298853_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 8.483e-230 732.0
HFD3_k127_3298853_1 signal transduction histidine kinase K03406 - - 0.0000000000000000000000000000000000000000000000003725 192.0
HFD3_k127_3298853_2 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000003405 108.0
HFD3_k127_3298853_3 Histidine kinase - - - 0.000002819 59.0
HFD3_k127_3299798_0 Sugar isomerase (SIS) K15916 - 5.3.1.8,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000001116 257.0
HFD3_k127_3306499_0 4Fe-4S single cluster domain K06937 - - 0.000000000000000000000000000000000000000000000000000000000000000000007629 244.0
HFD3_k127_3306499_1 Glycosyl transferase 4-like - - - 0.0000000000000000000000000000000000000000000001608 182.0
HFD3_k127_3306499_2 - - - - 0.0000000000000000000000000000000000000000000004316 169.0
HFD3_k127_3306499_3 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000009245 130.0
HFD3_k127_3306499_4 Protein of unknown function (DUF1616) - - - 0.00008896 51.0
HFD3_k127_3306720_0 Putative TM nitroreductase - - - 0.0000000000000000000000000000000000000000000000000009901 188.0
HFD3_k127_3306720_1 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E K07025 - - 0.00000000000000008408 89.0
HFD3_k127_3306720_2 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.000000000000006144 76.0
HFD3_k127_3436425_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 1.462e-260 831.0
HFD3_k127_3436425_1 Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane K15987 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002912 509.0
HFD3_k127_3436425_2 Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 417.0
HFD3_k127_3436425_3 Glutamine cyclotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001707 270.0
HFD3_k127_3436425_4 Luciferase-like monooxygenase K15510 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.98.2 0.0000000000000000000000000000000000000000000000000000000000000000000001815 250.0
HFD3_k127_3436425_5 Protein of unknown function (DUF3795) - - - 0.0000000000000000000000000000000000000000006015 162.0
HFD3_k127_3436425_6 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000004443 131.0
HFD3_k127_3436425_7 Dodecin K09165 - - 0.0000000000002911 72.0
HFD3_k127_3436425_8 PFAM DNA methylase N-4 N-6 K00571,K07316 - 2.1.1.72 0.000000003358 68.0
HFD3_k127_3436425_9 glucosylceramidase activity - - - 0.00008506 49.0
HFD3_k127_3443288_0 trehalose synthase activity K13057 - 2.4.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000808 466.0
HFD3_k127_3443288_1 Belongs to the glycosyl hydrolase 57 family K06044 - 5.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 340.0
HFD3_k127_3444581_0 ABC transporter K02010,K02017,K02052,K02062,K10112,K11072,K15497,K17240 - 3.6.3.29,3.6.3.30,3.6.3.31,3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008012 299.0
HFD3_k127_3444581_1 ABC-type Fe3 transport system permease component K02053,K02054,K02063 - - 0.0000000000000000000000000000000000000000000000000000000000001043 228.0
HFD3_k127_345611_0 chitinase activity K01183 GO:0003674,GO:0003824,GO:0004553,GO:0004568,GO:0005575,GO:0005576,GO:0006022,GO:0006026,GO:0006030,GO:0006032,GO:0006040,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016798,GO:0017144,GO:0042737,GO:0043170,GO:0044237,GO:0044248,GO:0046348,GO:0071704,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.2.1.14 0.00000000000000000000000000000000001879 157.0
HFD3_k127_345611_1 Methyltransferase domain - - - 0.0000000001842 70.0
HFD3_k127_345611_2 eight transmembrane protein EpsH - - - 0.00000005164 64.0
HFD3_k127_3472187_0 Aminoacyl-tRNA editing domain K19055 - - 0.000000000000000000000000003485 116.0
HFD3_k127_3472187_1 PFAM Glyoxalase bleomycin resistance protein dioxygenase K01759 - 4.4.1.5 0.00002283 49.0
HFD3_k127_3476751_0 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 362.0
HFD3_k127_3476751_1 Pirin K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008661 307.0
HFD3_k127_3476751_2 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000000000000000000000000000000002993 203.0
HFD3_k127_3476751_3 protein disulfide isomerase activity K17264 GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0005793,GO:0006457,GO:0006807,GO:0006810,GO:0006887,GO:0006950,GO:0006955,GO:0006986,GO:0008150,GO:0008152,GO:0009100,GO:0009986,GO:0009987,GO:0010033,GO:0012505,GO:0015036,GO:0015037,GO:0016020,GO:0016192,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0019725,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0031984,GO:0032940,GO:0033554,GO:0034774,GO:0034976,GO:0035580,GO:0035966,GO:0036230,GO:0042119,GO:0042175,GO:0042221,GO:0042581,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0045454,GO:0046903,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055114,GO:0060205,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0097708,GO:0098827,GO:0099503,GO:0140096,GO:1901135,GO:1901564 - 0.00000005386 58.0
HFD3_k127_3528694_0 AAA-like domain K06915 - - 0.0000000000000000009473 100.0
HFD3_k127_3528694_1 - - - - 0.000000000000000009336 88.0
HFD3_k127_359574_0 COG0463 Glycosyltransferases involved in cell wall biogenesis K13693 - 2.4.1.266 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 360.0
HFD3_k127_359574_1 Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG) K07026 - 3.1.3.70 0.000000000000000000000000000000000002319 144.0
HFD3_k127_36511_0 Rhodanese-like domain K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 456.0
HFD3_k127_36511_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009765 429.0
HFD3_k127_36511_10 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions - - - 0.0000000000000000000000000000000000001097 144.0
HFD3_k127_36511_11 PFAM glutaredoxin - - - 0.0000000000000003111 81.0
HFD3_k127_36511_12 Transcriptional regulator K07108,K22206 - - 0.00000000000001491 79.0
HFD3_k127_36511_13 Mo-molybdopterin cofactor metabolic process K03753 - - 0.0000598 46.0
HFD3_k127_36511_2 Hemerythrin HHE cation binding domain protein K09155 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007305 423.0
HFD3_k127_36511_3 Superoxide dismutase K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 289.0
HFD3_k127_36511_4 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003082 271.0
HFD3_k127_36511_5 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001516 264.0
HFD3_k127_36511_6 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000003391 232.0
HFD3_k127_36511_7 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000006051 195.0
HFD3_k127_36511_8 AhpC/TSA family K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000009066 190.0
HFD3_k127_36511_9 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000000000001485 157.0
HFD3_k127_3670615_0 PFAM Radical SAM domain protein K22227 - - 0.000000000000000000000000000000000000000000000000000000005573 213.0
HFD3_k127_3670615_1 PQQ enzyme repeat - - - 0.00000000000000000000000000000000000000000000000000000008125 222.0
HFD3_k127_3670615_2 Diphthamide synthase - - - 0.00000000000000000001508 98.0
HFD3_k127_3670615_3 PQQ-like domain K00114 - 1.1.2.8 0.0005116 53.0
HFD3_k127_367502_0 Glutamate synthase - - - 5.118e-217 684.0
HFD3_k127_367502_1 Phosphate uptake regulator - - - 0.000000000000000000000000000000000000000000000000005609 195.0
HFD3_k127_367502_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000000000000000000000007511 181.0
HFD3_k127_367502_3 PFAM metallophosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000002583 177.0
HFD3_k127_367502_4 Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000001167 166.0
HFD3_k127_367502_5 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.000000000000007835 85.0
HFD3_k127_367502_6 Belongs to the UPF0145 family - - - 0.00000000000006101 76.0
HFD3_k127_367502_7 - - - - 0.0000000003086 67.0
HFD3_k127_367502_8 Protein of unknown function DUF131 - - - 0.000000006119 60.0
HFD3_k127_367502_9 Protein of unknown function DUF131 - - - 0.00005738 49.0
HFD3_k127_3762436_0 PFAM Thiamine pyrophosphate enzyme, C-terminal TPP-binding K00158 - 1.2.3.3 0.00000000000000000000000000000000000000000000000000000000000000000006358 233.0
HFD3_k127_3762436_1 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000343 154.0
HFD3_k127_3762436_2 ribonuclease activity - - - 0.0000000000000003361 83.0
HFD3_k127_3762436_3 SpoVT / AbrB like domain - - - 0.000000000002662 68.0
HFD3_k127_3762436_4 Transcriptional regulator, AsnC family - - - 0.0006339 46.0
HFD3_k127_3793700_0 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004218 251.0
HFD3_k127_3793700_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000005302 170.0
HFD3_k127_3793700_2 Zn-dependent hydrolase - - - 0.000000001761 67.0
HFD3_k127_3793700_3 Domain of unknown function (DUF2088) - - - 0.0000001183 56.0
HFD3_k127_3793700_4 PQQ-like domain - - - 0.00008646 55.0
HFD3_k127_3840025_0 COG3666 Transposase and inactivated derivatives - - - 0.0001959 44.0
HFD3_k127_3840025_1 repeat protein - - - 0.0009325 46.0
HFD3_k127_384017_0 PFAM Thiamine pyrophosphate enzyme, C-terminal TPP-binding K00158 - 1.2.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 288.0
HFD3_k127_384017_1 Cleaves both 3' and 5' ssDNA extremities of branched DNA structures K07503 - - 0.0000000000000000000000000000000000000000000000000000006709 201.0
HFD3_k127_384017_2 Methyltransferase domain - - - 0.000000007603 59.0
HFD3_k127_3844048_0 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 302.0
HFD3_k127_3844986_0 Conserved hypothetical ATP binding protein K06883 - - 0.00000000000000000000000000000000000000000000000000000000000007599 221.0
HFD3_k127_3844986_1 molybdopterin binding domain - - - 0.000000000000000000000000000000000000000000000000000000000003275 218.0
HFD3_k127_3844986_2 Domain of unknown function (DUF4443) - - - 0.000000000000000001135 92.0
HFD3_k127_3844986_3 PFAM PEGA domain - - - 0.0000000001834 72.0
HFD3_k127_3854823_0 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 290.0
HFD3_k127_3854823_1 - - - - 0.00000000000000005955 82.0
HFD3_k127_3874409_0 Na Pi-cotransporter II-like protein K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002609 381.0
HFD3_k127_3874409_1 Protein of unknown function (DUF3795) - - - 0.00000000000000000000000000000003238 128.0
HFD3_k127_3874409_2 GAF domain - - - 0.0000000000000000000000000665 110.0
HFD3_k127_3874409_3 PFAM regulatory protein AsnC Lrp family - - - 0.00000001037 59.0
HFD3_k127_3902304_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 562.0
HFD3_k127_3902304_1 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 311.0
HFD3_k127_3902304_2 HMGL-like K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000004097 275.0
HFD3_k127_3902304_3 PFAM UbiA prenyltransferase K17105 - 2.5.1.42 0.000000000000000000000000000000000000000000000001829 184.0
HFD3_k127_3919960_0 SMART KH domain protein K07041 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009597 498.0
HFD3_k127_3919960_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 494.0
HFD3_k127_3919960_2 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 328.0
HFD3_k127_3919960_3 Pfam:DUF552 K09152 - - 0.0000000000000000000182 97.0
HFD3_k127_3919960_4 Transcriptional regulator - - - 0.000000002124 62.0
HFD3_k127_3933775_0 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000437 220.0
HFD3_k127_3933775_1 MgtC family K07507 - - 0.000000000000000000000000000000000001919 142.0
HFD3_k127_3933775_2 - - - - 0.0000000000000000000000004931 109.0
HFD3_k127_3934090_0 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003984 394.0
HFD3_k127_3934090_1 positive regulation of growth - - - 0.00000000000000000000000000000000000000000000000006858 191.0
HFD3_k127_3934090_2 PAC2 family K07159 - - 0.00000000000000000000000000000003582 134.0
HFD3_k127_3934090_3 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex - - - 0.0000000000000000000000006849 119.0
HFD3_k127_3934090_4 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000006992 103.0
HFD3_k127_3934090_5 binds to the 23S rRNA K02896 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - 0.00000000000003502 72.0
HFD3_k127_3942462_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007477 287.0
HFD3_k127_3942591_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005517 284.0
HFD3_k127_3942591_1 Orotidine 5'-phosphate decarboxylase / HUMPS family K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000001515 177.0
HFD3_k127_3942591_2 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - 0.000000000000000000000000003314 115.0
HFD3_k127_3942591_3 EamA-like transporter family K03298 - - 0.000000000000000000001189 102.0
HFD3_k127_3942591_4 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.0000000000009751 69.0
HFD3_k127_3964333_0 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000005875 254.0
HFD3_k127_3964333_1 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000168 204.0
HFD3_k127_3964333_2 integral membrane protein K07027 - - 0.000000001101 68.0
HFD3_k127_3970366_0 PFAM Polysaccharide pyruvyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005637 397.0
HFD3_k127_3970366_1 AMP-binding enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008307 248.0
HFD3_k127_3970366_2 Pfam:Gp37_Gp68 - - - 0.0000000000000000000000000000000000000000000000000000000000002619 219.0
HFD3_k127_3970366_3 flavodoxin K00230 - 1.3.5.3 0.000000000000000000000000008089 119.0
HFD3_k127_3992560_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 5.433e-217 687.0
HFD3_k127_3992560_1 DNA polymerase alpha chain like domain - - - 0.000000000000000000000000000000000000000256 157.0
HFD3_k127_4015332_0 deoxyribonuclease I - - - 0.00000000000000000000000000000000000000000000000000000000004557 215.0
HFD3_k127_4015332_1 - - - - 0.0003502 49.0
HFD3_k127_4025497_0 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.000000000000000000000000000000000002444 141.0
HFD3_k127_4025497_1 4Fe-4S binding domain - - - 0.00000000000000000000008364 101.0
HFD3_k127_4025497_2 helix_turn_helix, Arsenical Resistance Operon Repressor K03892,K21903 - - 0.0000000000000008167 81.0
HFD3_k127_4025497_3 Copper resistance protein CopZ K07213 - - 0.0005734 46.0
HFD3_k127_4042383_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 413.0
HFD3_k127_4042383_1 Uncharacterized protein conserved in bacteria (DUF2090) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008559 314.0
HFD3_k127_4042383_2 - - - - 0.000000000000000000000000000000000000000002082 159.0
HFD3_k127_4042383_3 - - - - 0.00009243 46.0
HFD3_k127_4047802_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 580.0
HFD3_k127_4047802_1 MoeA C-terminal region (domain IV) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 347.0
HFD3_k127_4047802_2 MoeA C-terminal region (domain IV) K03750 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000002475 277.0
HFD3_k127_4047802_3 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000003178 234.0
HFD3_k127_4047802_4 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000001665 205.0
HFD3_k127_4047802_5 mevalonate kinase activity K00869,K15633 GO:0003674,GO:0003824,GO:0004496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005829,GO:0006066,GO:0006084,GO:0006139,GO:0006163,GO:0006629,GO:0006637,GO:0006644,GO:0006694,GO:0006695,GO:0006720,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009150,GO:0009240,GO:0009259,GO:0009987,GO:0016125,GO:0016126,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019287,GO:0019637,GO:0019693,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046483,GO:0046490,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653 2.7.1.36,5.4.2.12 0.0000000000000000000000000000000000000000000000003381 185.0
HFD3_k127_4117072_0 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.000000000000000000000000000000000000000000000000000000000000000000000000000003661 272.0
HFD3_k127_4117072_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000000000000000000000006742 103.0
HFD3_k127_4117072_2 FUN14 family - - - 0.00000000000007715 75.0
HFD3_k127_412182_0 Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000003332 144.0
HFD3_k127_412182_1 NAD-dependent epimerase dehydratase K01897 - 6.2.1.3 0.0000000000000000000000000005489 126.0
HFD3_k127_412182_2 Glycosyl transferases group 1 - - - 0.000000000000000000000008645 104.0
HFD3_k127_412182_3 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.000001758 59.0
HFD3_k127_4131428_0 Radical SAM domain protein K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000615 310.0
HFD3_k127_4131428_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000004268 248.0
HFD3_k127_4131428_2 - - - - 0.000000000000000000000000000000000000000000000000000000001431 209.0
HFD3_k127_4131428_3 endonuclease containing a URI domain K07461 - - 0.000000000000000007002 89.0
HFD3_k127_4131428_4 helix_turn_helix multiple antibiotic resistance protein - - - 0.00006976 50.0
HFD3_k127_4144274_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 546.0
HFD3_k127_4144274_1 PFAM tRNA synthetase, class II (D, K and N) K01893 - 6.1.1.22 0.000000000000000000000000000000000000000000000000000000001741 204.0
HFD3_k127_4194605_0 PFAM transferase hexapeptide repeat containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 435.0
HFD3_k127_4194605_1 tRNA intron endonuclease, N-terminal domain K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000001119 197.0
HFD3_k127_4194605_2 - - - - 0.000000007189 66.0
HFD3_k127_4314923_0 Zn-dependent protease with chaperone function K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 318.0
HFD3_k127_4314923_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000008564 231.0
HFD3_k127_4319021_0 Radical SAM domain protein K06871 - - 0.0000000000000000000000000000000000000000000002216 186.0
HFD3_k127_4319021_1 radical SAM domain protein K06871 - - 0.000000000000000000000000000000000000005867 162.0
HFD3_k127_4319021_2 Alpha amylase, catalytic domain K01176 - 3.2.1.1 0.0000000000000000000000000000001286 128.0
HFD3_k127_4324606_0 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000000000001675 107.0
HFD3_k127_4324606_1 type II secretion system protein K07333 - - 0.0000000000000000000007711 104.0
HFD3_k127_435606_0 PFAM Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000001361 187.0
HFD3_k127_435606_1 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000005667 91.0
HFD3_k127_435606_2 transcription factor (CBF NF-Y) - - - 0.00000000000000209 78.0
HFD3_k127_4378633_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009054 427.0
HFD3_k127_4378633_1 PFAM FAD dependent oxidoreductase K07137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006396 400.0
HFD3_k127_4378633_2 SMART zinc finger, RanBP2-type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002316 371.0
HFD3_k127_4378633_3 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.0000000000000000000000000005334 115.0
HFD3_k127_4378633_4 - - - - 0.00000000000000000000000002867 114.0
HFD3_k127_4378633_5 COG1198 Primosomal protein N' (replication factor Y) - superfamily II helicase - - - 0.000000000007646 75.0
HFD3_k127_4381809_0 Oxidoreductase NAD-binding domain K15765 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 492.0
HFD3_k127_4381809_1 Nickel-dependent hydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 307.0
HFD3_k127_4381809_2 NADH ubiquinone oxidoreductase, 20 Kd subunit K14128 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002872 307.0
HFD3_k127_438440_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000004663 168.0
HFD3_k127_438440_1 antiporter K07301 - - 0.00000000000000000000000006155 119.0
HFD3_k127_4413817_0 AAA ATPase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 357.0
HFD3_k127_4413817_1 AAA ATPase domain - - - 0.0000026 52.0
HFD3_k127_4447587_0 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003564 342.0
HFD3_k127_4447587_1 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004473 330.0
HFD3_k127_4447587_2 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000225 286.0
HFD3_k127_4447587_3 B12 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003862 253.0
HFD3_k127_4447587_4 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.000000000000000000000000000000000000000000000000000000002155 212.0
HFD3_k127_4455307_0 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 364.0
HFD3_k127_4455307_1 hydrogenase expression formation protein K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000668 261.0
HFD3_k127_4527900_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 621.0
HFD3_k127_4527900_1 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 458.0
HFD3_k127_4527900_2 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000652 406.0
HFD3_k127_4527900_3 Domain of unknown function (DUF4342) - - - 0.000000000000672 73.0
HFD3_k127_4527900_4 TIGRFAM MoaD family protein K03636 - - 0.000000000008959 68.0
HFD3_k127_4527900_5 Major facilitator superfamily - - - 0.00000003798 65.0
HFD3_k127_4553452_0 Superfamily I DNA and RNA - - - 1.918e-211 711.0
HFD3_k127_4553452_1 TIGRFAM Ammonium transporter K03320 - - 0.000000000000000000000000000000197 126.0
HFD3_k127_4570108_0 DEAD DEAH box helicase domain protein K03724 - - 1.501e-252 809.0
HFD3_k127_4570108_1 RNA methylase - GO:0003674,GO:0003824,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018022,GO:0018193,GO:0018205,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000174 181.0
HFD3_k127_4570108_2 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.00000000000000000000000000000000004407 139.0
HFD3_k127_4570108_3 Protein of unknown function (DUF424) K09148 - - 0.000000000000000000000002371 106.0
HFD3_k127_4570108_4 LURP-one-related - - - 0.000000000000001902 83.0
HFD3_k127_4570108_5 COG0681 Signal peptidase I K13280 - 3.4.21.89 0.000001263 58.0
HFD3_k127_4618425_0 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 452.0
HFD3_k127_4618425_1 PFAM Glycosyl transferase, group 1 K16150 - 2.4.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 387.0
HFD3_k127_4618425_2 Domain of unknown function (DUF4438) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007033 348.0
HFD3_k127_4618425_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.00000000000000000000000000000001249 134.0
HFD3_k127_4618425_4 ribosomal protein K02976 - - 0.0000000000000000000000000000004559 124.0
HFD3_k127_4618425_5 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000002215 113.0
HFD3_k127_4618425_6 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000001319 98.0
HFD3_k127_4618425_7 PFAM CBS domain containing protein - - - 0.00000000000006698 75.0
HFD3_k127_4618425_8 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000001053 61.0
HFD3_k127_462471_0 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000001964 99.0
HFD3_k127_4646657_0 protein kinase activity - - - 0.0000323 51.0
HFD3_k127_4667390_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000386 523.0
HFD3_k127_4667390_1 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K07533 - 5.2.1.8 0.00000000000000000000000000003489 118.0
HFD3_k127_4667390_2 helix_turn_helix ASNC type K03719 - - 0.000000009909 60.0
HFD3_k127_4684175_0 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004349 584.0
HFD3_k127_4694394_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 528.0
HFD3_k127_4694394_1 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 387.0
HFD3_k127_4694394_2 DeoC/LacD family aldolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000814 381.0
HFD3_k127_4694394_3 - - - - 0.0000000000000000000000000000242 137.0
HFD3_k127_471326_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003948 550.0
HFD3_k127_471326_1 PFAM S-layer - - - 0.000000000000000000000000000000000000000000000000000000000000000004182 236.0
HFD3_k127_4714270_0 formylmethanofuran dehydrogenase, subunit E K11261 - 1.2.7.12 0.00000000000000000000000000000000001302 142.0
HFD3_k127_4714270_1 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000000000000002973 100.0
HFD3_k127_4730345_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 442.0
HFD3_k127_4730345_1 alkyl hydroperoxide reductase activity - - - 0.00000000000000000000000000000000000000000000000000000002936 203.0
HFD3_k127_4730345_2 pfam yhs - - - 0.00000000000000001002 84.0
HFD3_k127_4730345_3 pfam yhs - - - 0.00000000000002637 75.0
HFD3_k127_4733083_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 488.0
HFD3_k127_4733083_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007319 329.0
HFD3_k127_4733083_2 ABC transporter, ATP-binding protein K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006222 261.0
HFD3_k127_4733460_0 Pentapeptide repeats (9 copies) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 351.0
HFD3_k127_4741369_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0016829,GO:0016835,GO:0016838,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 516.0
HFD3_k127_4741369_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006452 453.0
HFD3_k127_4741369_10 In the absence or at low concentrations of lysine, activates the biosynthesis of this amino acid via the alpha- aminoadipate (AAA) pathway K06154 - - 0.0000000000000000000000000000002089 128.0
HFD3_k127_4741369_11 Phosphate uptake regulator - - - 0.0000000000000000000000006877 116.0
HFD3_k127_4741369_12 lysine biosynthesis protein LysW K05826 - - 0.000000000001138 70.0
HFD3_k127_4741369_13 glutamyl-tRNA reductase activity K02407,K02492,K10714,K15671 GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 0.0000000002065 65.0
HFD3_k127_4741369_14 Belongs to the RimK family K05827 - 6.3.2.43 0.0000007602 61.0
HFD3_k127_4741369_2 Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily K05829 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 419.0
HFD3_k127_4741369_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K05830 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 419.0
HFD3_k127_4741369_4 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 368.0
HFD3_k127_4741369_5 Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine K05831 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008889 320.0
HFD3_k127_4741369_6 Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) K05828 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004992 286.0
HFD3_k127_4741369_7 PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit K00441,K22174 - 1.1.98.4,1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000004444 233.0
HFD3_k127_4741369_8 Cupin domain - - - 0.00000000000000000000000000000000000000000000000005466 182.0
HFD3_k127_4741369_9 diphthine-ammonia ligase activity K06927 - 6.3.1.14 0.000000000000000000000000000000000000000000003576 171.0
HFD3_k127_4750881_0 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000009213 241.0
HFD3_k127_4750881_1 thymidylate kinase K00943 - 2.7.4.9 0.00000000000000000000000000000000000000508 152.0
HFD3_k127_4750881_2 EVE domain - - - 0.00000000000000000000764 99.0
HFD3_k127_4750881_3 PFAM phosphatidate cytidylyltransferase K18678 - 2.7.1.182 0.0000000000000000001034 95.0
HFD3_k127_4750881_4 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.0000002574 57.0
HFD3_k127_4750881_5 PFAM Ornithine cyclodeaminase mu-crystallin K01750,K19743 - 1.5.1.1,4.3.1.12 0.000002104 50.0
HFD3_k127_4835983_0 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 381.0
HFD3_k127_4835983_1 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000027 194.0
HFD3_k127_4835983_2 4Fe-4S single cluster domain - - - 0.000000000000000000000000000000000000000000000000333 189.0
HFD3_k127_4835983_3 xanthine phosphoribosyltransferase activity K00769,K07101 - 2.4.2.22 0.0000000000000000000000000000000000000001309 155.0
HFD3_k127_4838852_0 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 1.32e-231 731.0
HFD3_k127_4838852_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 5.834e-223 707.0
HFD3_k127_4838852_10 acetyltransferase - - - 0.000000000002575 76.0
HFD3_k127_4838852_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005482 572.0
HFD3_k127_4838852_3 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 466.0
HFD3_k127_4838852_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000484 332.0
HFD3_k127_4838852_5 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity K01955 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007088 282.0
HFD3_k127_4838852_6 Leucyl aminopeptidase (Aminopeptidase t) - - - 0.000000000000000000000000000000000002188 148.0
HFD3_k127_4838852_7 PFAM PfkB - - - 0.000000000000000000000000000000001428 141.0
HFD3_k127_4838852_8 Protein of unknown function (DUF1294) - - - 0.0000000000000000005763 89.0
HFD3_k127_4838852_9 - - - - 0.0000000000000006051 79.0
HFD3_k127_4848409_0 4Fe-4S dicluster domain - - - 0.00000000000000000000000000005739 123.0
HFD3_k127_4848409_1 PQQ-like domain - - - 0.00000001033 67.0
HFD3_k127_4859953_0 PFAM Cytidine and deoxycytidylate deaminase zinc-binding region K01485 - 3.5.4.1 0.00000000000000000000000000000000000000000000000000000000000000000004806 233.0
HFD3_k127_4859953_1 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000003783 230.0
HFD3_k127_4859953_2 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.000000000000000000000000000000000000000000000000000002547 198.0
HFD3_k127_4859953_3 pfam abc K02003 - - 0.00000000000000000000000000000000000000000000000001009 202.0
HFD3_k127_4859953_4 signal transduction protein with CBS domains - - - 0.000000000000000000004975 103.0
HFD3_k127_4859953_5 ABC-type transport system, involved in lipoprotein release, permease component K02004 - - 0.00000000000000000008606 106.0
HFD3_k127_4859953_6 signal transduction protein with CBS domains - - - 0.0000000000000001452 90.0
HFD3_k127_4859953_7 PFAM CBS domain containing protein - - - 0.000000000000003758 82.0
HFD3_k127_48670_0 cellular manganese ion homeostasis - - - 0.00000000000000000244 91.0
HFD3_k127_48670_1 - - - - 0.0005231 44.0
HFD3_k127_4875596_0 Protein of unknown function (DUF2961) K14109 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 321.0
HFD3_k127_4875596_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 295.0
HFD3_k127_4875596_2 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001069 283.0
HFD3_k127_4876215_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 431.0
HFD3_k127_4876215_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K09163 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 294.0
HFD3_k127_4876215_2 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000001874 192.0
HFD3_k127_4876215_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000004554 190.0
HFD3_k127_4876215_4 Serine threonine protein kinase K07178 - 2.7.11.1 0.0000000000000000000000000000000000000002076 154.0
HFD3_k127_4876215_5 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000007657 118.0
HFD3_k127_4876215_6 Cytochrome b5-like Heme/Steroid binding domain - - - 0.000000000000000002196 86.0
HFD3_k127_4893089_0 PIN domain - - - 0.00000000000000002647 87.0
HFD3_k127_4893089_1 TIGRFAM looped-hinge helix DNA binding domain, AbrB family - - - 0.00001622 51.0
HFD3_k127_4898917_0 Putative undecaprenyl diphosphate synthase K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000134 284.0
HFD3_k127_4898917_1 UPF0056 membrane protein K05595 - - 0.0000000000000000000000000000000004819 138.0
HFD3_k127_4898917_2 PFAM SNARE associated Golgi protein - - - 0.000000000000000000001907 100.0
HFD3_k127_4898917_3 - - - - 0.0000000000000004323 87.0
HFD3_k127_4898917_4 SNARE associated Golgi protein K01077 - 3.1.3.1 0.00000000000008541 77.0
HFD3_k127_4898917_5 - - - - 0.00000000001014 72.0
HFD3_k127_4898917_6 - K00960 - 2.7.7.6 0.0000001398 61.0
HFD3_k127_4898917_7 - - - - 0.000005096 55.0
HFD3_k127_4898917_8 zinc finger, SWIM - - - 0.0008481 45.0
HFD3_k127_4910836_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 549.0
HFD3_k127_4910836_1 Ser thr protein kinase K07176 - - 0.00000000000000000000002217 104.0
HFD3_k127_4910836_2 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.000000005344 57.0
HFD3_k127_4913061_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000493 66.0
HFD3_k127_4913061_1 PFAM PEGA domain - - - 0.0000001418 64.0
HFD3_k127_4928880_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 4.236e-212 674.0
HFD3_k127_4928880_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005754 589.0
HFD3_k127_4928880_10 Domain of unknown function (DUF1893) - - - 0.00000000004782 69.0
HFD3_k127_4928880_11 Pyridine nucleotide-disulphide oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000003778 65.0
HFD3_k127_4928880_2 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528,K16951 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 295.0
HFD3_k127_4928880_3 Thioredoxin reductase K00384,K03387 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 292.0
HFD3_k127_4928880_4 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000047 253.0
HFD3_k127_4928880_5 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000007011 123.0
HFD3_k127_4928880_6 Transcriptional regulator K07722 - - 0.000000000000000000000000000225 119.0
HFD3_k127_4928880_7 Heterodisulfide reductase subunit A and related polyferredoxins K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000003412 94.0
HFD3_k127_4928880_8 - - - - 0.000000000000008822 82.0
HFD3_k127_4928880_9 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000007794 71.0
HFD3_k127_4948386_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147,K15515 GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41,1.2.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 498.0
HFD3_k127_4948386_1 COG0433 Predicted ATPase K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 404.0
HFD3_k127_4948386_10 PFAM NurA domain - - - 0.000000000000000007353 95.0
HFD3_k127_4948386_11 Transcriptional regulator PadR-like family - - - 0.0000000000007269 76.0
HFD3_k127_4948386_2 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 363.0
HFD3_k127_4948386_3 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001991 286.0
HFD3_k127_4948386_4 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002219 259.0
HFD3_k127_4948386_5 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000005432 207.0
HFD3_k127_4948386_6 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000002213 184.0
HFD3_k127_4948386_7 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000009938 149.0
HFD3_k127_4948386_8 NUDIX domain - - - 0.00000000000000000000000000000002717 131.0
HFD3_k127_4978425_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 465.0
HFD3_k127_4978425_1 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003131 450.0
HFD3_k127_4978425_2 AIR synthase related protein, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000477 333.0
HFD3_k127_4978425_3 UBA THIF-type NAD FAD binding protein K03148,K21029 - 2.7.7.73,2.7.7.80 0.00000000000000000000000000000000000000000000000000000000001939 219.0
HFD3_k127_4978425_4 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000003426 134.0
HFD3_k127_4978425_5 ECF-type riboflavin transporter, S component - - - 0.00000000000000000000000000004141 123.0
HFD3_k127_5003693_0 Amino acid kinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000001063 236.0
HFD3_k127_5003693_1 Belongs to the eIF-2B alpha beta delta subunits family K18237 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.29 0.00000000000000000000000000000000000000000000000000000000000001025 227.0
HFD3_k127_5003693_2 GH3 auxin-responsive promoter - - - 0.00000000000000003481 94.0
HFD3_k127_5018066_0 Radical_SAM C-terminal domain K07739 - 2.3.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004888 537.0
HFD3_k127_5018066_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 426.0
HFD3_k127_5018066_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 334.0
HFD3_k127_5018066_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 336.0
HFD3_k127_5018066_4 Protein of unknown function (DUF429) K09147 - - 0.000000000000000000000000000000000000000000000000000004421 196.0
HFD3_k127_5018066_5 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000000000000000000000000000000000000001764 207.0
HFD3_k127_5018066_6 NAD(P)H dehydrogenase (quinone) activity - - - 0.0000000000000000000000000000000004862 134.0
HFD3_k127_5018066_7 Ribosomal protein S30 K02983 - - 0.0000000008166 61.0
HFD3_k127_5152855_0 COG0463 Glycosyltransferases involved in cell wall biogenesis K13693 - 2.4.1.266 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002542 389.0
HFD3_k127_5152855_1 Hydrolyzes mannosyl-3-phosphoglycerate (MPG) to form the osmolyte mannosylglycerate (MG) K07026 - 3.1.3.70 0.0000000000000000000000000000000000000000000000000003746 194.0
HFD3_k127_530792_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006196 359.0
HFD3_k127_530792_1 Belongs to the eukaryotic ribosomal protein eL15 family K02877 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000003185 187.0
HFD3_k127_530792_2 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.000000000000000000000000000000000000000000116 173.0
HFD3_k127_5376556_0 PFAM CBS domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 469.0
HFD3_k127_5376556_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 462.0
HFD3_k127_5376556_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 388.0
HFD3_k127_5376556_3 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001881 380.0
HFD3_k127_5376556_4 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005177 295.0
HFD3_k127_5376556_5 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000003261 261.0
HFD3_k127_5376556_6 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000007305 184.0
HFD3_k127_5452798_0 Belongs to the carbamoyltransferase HypF family K04656 - - 6.217e-197 633.0
HFD3_k127_5452798_1 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 504.0
HFD3_k127_5454754_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008125 317.0
HFD3_k127_5454754_1 PFAM peptidase S1 and S6, chymotrypsin Hap K08070 - 1.3.1.74 0.00000000000000000000000000000000000000000000000000000000000000001705 240.0
HFD3_k127_5454754_2 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000008872 166.0
HFD3_k127_5454754_3 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000000002181 161.0
HFD3_k127_5514304_0 Multicopper oxidase K06324 - 1.16.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000002036 254.0
HFD3_k127_5514304_1 PFAM Rieske 2Fe-2S domain K05710 - - 0.000000000000000000000003431 104.0
HFD3_k127_5524170_0 glycosyl transferase group 1 K13057 - 2.4.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006993 471.0
HFD3_k127_5524170_1 Belongs to the glycosyl hydrolase 57 family K06044 - 5.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 428.0
HFD3_k127_5524170_2 PFAM peptidase M3A and M3B, thimet oligopeptidase F K08602 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003641 263.0
HFD3_k127_5564805_0 Matrixin - - - 0.000000000000000000000000000000000000001352 156.0
HFD3_k127_5564805_1 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.0000000000002911 72.0
HFD3_k127_5564805_2 Domain of unknown function (DUF362) - - - 0.0005322 47.0
HFD3_k127_5567951_0 NADH ubiquinone oxidoreductase, F subunit, iron sulphur binding K00335,K18331,K22339 - 1.12.1.3,1.17.1.11,1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005784 454.0
HFD3_k127_5567951_1 Thioredoxin-like [2Fe-2S] ferredoxin K05586 - 1.6.5.3 0.0000000000000000000000000000000000000000000001005 173.0
HFD3_k127_55753_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 516.0
HFD3_k127_55753_1 Tyrosine--tRNA ligase K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007118 397.0
HFD3_k127_55753_10 SMART Like-Sm ribonucleoprotein, eukaryotic and archaea-type, core K04796 - - 0.0000000007394 63.0
HFD3_k127_55753_2 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 343.0
HFD3_k127_55753_3 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 300.0
HFD3_k127_55753_4 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000001262 228.0
HFD3_k127_55753_5 Peptidyl-prolyl cis-trans K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000002542 211.0
HFD3_k127_55753_6 Lipoate-protein ligase K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000000001205 184.0
HFD3_k127_55753_7 CBS domain K03498 - - 0.000000000000000000000000000000000000000008582 171.0
HFD3_k127_55753_8 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000000000000000000000000006925 138.0
HFD3_k127_55753_9 SMART Toprim sub domain protein - - - 0.00000000000000009983 85.0
HFD3_k127_5606257_0 Putative RNA methyltransferase K09142 - - 0.00000000000000000000000000000000000000000000000000000000000001424 226.0
HFD3_k127_5606257_1 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000008376 199.0
HFD3_k127_5606257_2 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000006725 193.0
HFD3_k127_5606257_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.000000000000000000000000000000000000000000000000007891 191.0
HFD3_k127_5606257_4 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.00000000000000000000000000000000000000003646 163.0
HFD3_k127_5606257_5 Transcription elongation factor Spt5 K02601 - - 0.000000000000000000000000000000000000002372 151.0
HFD3_k127_5606257_6 - - - - 0.00000000000000000000000000000001255 131.0
HFD3_k127_5606257_7 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000008499 100.0
HFD3_k127_5606257_8 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.0000000000000000000001523 100.0
HFD3_k127_5606257_9 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00003242 49.0
HFD3_k127_5624651_0 Endopeptidase La K04076 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003851 599.0
HFD3_k127_5624651_1 PFAM Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000001227 130.0
HFD3_k127_5624651_2 Uncharacterized conserved protein (DUF2196) - - - 0.000000000000000007295 84.0
HFD3_k127_5630109_0 Ferrous iron transport protein B K04759 - - 1.648e-258 812.0
HFD3_k127_5630109_1 Endopeptidase La - - - 5.083e-238 760.0
HFD3_k127_5630109_10 Winged helix-turn-helix - - - 0.0009906 45.0
HFD3_k127_5630109_2 D-isomer specific 2-hydroxyacid dehydrogenase catalytic region K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 398.0
HFD3_k127_5630109_3 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005867 374.0
HFD3_k127_5630109_4 Iron dependent K03709 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 298.0
HFD3_k127_5630109_5 ATP binding protein K06927 - 6.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000001984 256.0
HFD3_k127_5630109_6 peptidase - - - 0.0000000000000000000000000000000000000001839 161.0
HFD3_k127_5630109_7 PFAM Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000004833 137.0
HFD3_k127_5630109_8 Pfam:DUF650 - - - 0.0000000000000002992 79.0
HFD3_k127_5648232_0 CoA binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 436.0
HFD3_k127_5648232_1 PFAM ATP-grasp domain K22224 - 6.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000009871 235.0
HFD3_k127_5648232_2 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000000000000000000000001958 206.0
HFD3_k127_5648232_3 Peptidase A4 family - - - 0.0000000000009902 70.0
HFD3_k127_5648232_4 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.0000000001668 66.0
HFD3_k127_5664053_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004476 562.0
HFD3_k127_5664053_1 Domain of unknown function (DUF4062) - - - 0.0000000000000000000000000000000000000000000000000000000003143 217.0
HFD3_k127_5664053_2 4-amino-4-deoxy-L-arabinose transferase activity K14340 - - 0.0000000000001128 73.0
HFD3_k127_5664720_0 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004824 315.0
HFD3_k127_5664720_1 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.0000000000000000000000000000000000000000000000000001326 195.0
HFD3_k127_5664720_2 Belongs to the UPF0107 family K09128 - - 0.0000000000000000000000000000000000000005352 151.0
HFD3_k127_5690937_0 Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0005488,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0008964,GO:0009987,GO:0015977,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046872,GO:0071704 4.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008846 434.0
HFD3_k127_5690937_1 Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0005488,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0008964,GO:0009987,GO:0015977,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046872,GO:0071704 4.1.1.31 0.0000000000582 64.0
HFD3_k127_5742747_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 574.0
HFD3_k127_5742747_1 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 296.0
HFD3_k127_5742747_2 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000002231 130.0
HFD3_k127_5749656_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005321 440.0
HFD3_k127_5753012_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005939 280.0
HFD3_k127_5753012_1 Adenosine specific kinase K09129 - - 0.00000000000000000000000000000000000000000000000000000000000000001379 228.0
HFD3_k127_5753012_2 - K00960 - 2.7.7.6 0.0000008066 51.0
HFD3_k127_5769560_0 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000001778 257.0
HFD3_k127_5769560_1 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000002032 111.0
HFD3_k127_5769560_2 transferase activity, transferring glycosyl groups - - - 0.0000000003068 64.0
HFD3_k127_5769560_3 Hypothetical glycosyl hydrolase family 15 - - - 0.0000003936 62.0
HFD3_k127_5778314_0 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000848 293.0
HFD3_k127_5778314_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 301.0
HFD3_k127_5778314_2 Predicted membrane protein (DUF2318) K09005 - - 0.00000000000000000826 92.0
HFD3_k127_5778314_3 COG1136 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000005025 55.0
HFD3_k127_5820367_0 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003461 278.0
HFD3_k127_5820367_1 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000006387 142.0
HFD3_k127_5820367_2 Belongs to the peptidase M10A family K07999 - - 0.00002151 56.0
HFD3_k127_5820367_3 Ferredoxin K05337 - - 0.00008191 48.0
HFD3_k127_5837376_0 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 358.0
HFD3_k127_5837376_1 HNH endonuclease - - - 0.0001036 52.0
HFD3_k127_5845387_0 Oxidoreductase molybdopterin binding - - - 0.000000000000000000000000000000000000000003043 162.0
HFD3_k127_5875801_0 integral membrane protein K07027 - - 0.00001652 57.0
HFD3_k127_5875801_1 - - - - 0.00002869 48.0
HFD3_k127_5900540_0 TIGRFAM geranylgeranyl reductase K17830 - 1.3.1.101,1.3.7.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 355.0
HFD3_k127_5900540_1 PFAM tRNA synthetase, class II (D, K and N) K01893 - 6.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000007589 244.0
HFD3_k127_5900540_2 PFAM regulatory protein AsnC Lrp family K03718 - - 0.0000000000000000000000000000000000000007319 153.0
HFD3_k127_5900540_3 HxlR-like helix-turn-helix - - - 0.000000001073 65.0
HFD3_k127_592084_0 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000009029 183.0
HFD3_k127_592084_1 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000001127 77.0
HFD3_k127_592084_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000001861 58.0
HFD3_k127_5934644_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003342 613.0
HFD3_k127_5934644_1 Protein of unknown function (DUF3175) - - - 0.00000000000000000007866 91.0
HFD3_k127_5949173_0 Belongs to the N(4) N(6)-methyltransferase family K00590 - 2.1.1.113 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003976 349.0
HFD3_k127_5949173_1 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006259 335.0
HFD3_k127_5949173_2 methanogenesis marker protein 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002887 269.0
HFD3_k127_5949173_3 ABC-type cobalt transport system, permease component - - - 0.0000000000000000000000000000000000000000475 158.0
HFD3_k127_5949173_4 Transcriptional regulator K03524 - 6.3.4.15 0.0000000000000000000000000000001953 133.0
HFD3_k127_5949173_5 4Fe-4S dicluster domain - - - 0.0000000000000000000000001124 117.0
HFD3_k127_5949173_6 - - - - 0.0000000000000000000888 98.0
HFD3_k127_5949173_7 2TM domain - - - 0.0000000000001845 74.0
HFD3_k127_5953882_0 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 318.0
HFD3_k127_5953882_1 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006249 295.0
HFD3_k127_5953882_10 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.00000002521 56.0
HFD3_k127_5953882_2 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934,K21479 - 2.1.1.131,2.1.1.272 0.00000000000000000000000000000000000000000000000000000000000000000000000009382 256.0
HFD3_k127_5953882_3 Cobalamin synthesis G C-terminus K02189 - 3.7.1.12 0.0000000000000000000000000000000000000000000000000000000002179 216.0
HFD3_k127_5953882_4 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000001687 207.0
HFD3_k127_5953882_5 Transcriptional regulator K07730 - - 0.00000000000000000000000000000000000000000000000000002051 198.0
HFD3_k127_5953882_6 Tetrapyrrole (Corrin/Porphyrin) Methylases K03394 - 2.1.1.130,2.1.1.151 0.00000000000000000000000000000000000000000000000000619 190.0
HFD3_k127_5953882_7 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.00000000000000000000000000000000000000000001255 166.0
HFD3_k127_5953882_8 Protein of unknown function (DUF2769) - - - 0.0000000000001675 72.0
HFD3_k127_5953882_9 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000005465 79.0
HFD3_k127_5965635_0 Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000006832 227.0
HFD3_k127_6005603_0 Peptidase family M20/M25/M40 K01439 - 3.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007809 280.0
HFD3_k127_6005603_1 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000008332 123.0
HFD3_k127_6005603_2 transcriptional - GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009889,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - 0.0000872 51.0
HFD3_k127_6036011_0 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000212 270.0
HFD3_k127_6036011_1 - - - - 0.0000000000000000000000000000000000000000000005138 177.0
HFD3_k127_6036011_2 dehydrogenases and related proteins - - - 0.00000000000000000000000000000000000000000008931 172.0
HFD3_k127_6036011_3 Glycosyltransferase - - - 0.0000000000000000000000000000000001073 147.0
HFD3_k127_6036011_4 PFAM Glycosyl transferases group 1 - - - 0.000000000002236 72.0
HFD3_k127_6036011_5 Glycosyl transferase 4-like domain - - - 0.0002157 50.0
HFD3_k127_6051284_0 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000008387 196.0
HFD3_k127_6051284_1 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.0000000000000000000000000000000000005549 145.0
HFD3_k127_6051284_2 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K03294 - - 0.0000000000000000000000000000002089 128.0
HFD3_k127_6051284_3 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000000000000000003005 129.0
HFD3_k127_6051284_4 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000002397 106.0
HFD3_k127_6051284_5 Lrp/AsnC ligand binding domain - - - 0.00000000000000004049 83.0
HFD3_k127_6064501_0 Protein of unknown function (DUF763) K09003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004492 399.0
HFD3_k127_6064501_1 Elongator protein 3, MiaB family, Radical SAM K09711 - - 0.0000000000000000000000000000000000000000000000000000000000000000003054 241.0
HFD3_k127_6064501_2 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000007221 142.0
HFD3_k127_6064501_3 Protein of unknown function (DUF998) - - - 0.000000000004222 74.0
HFD3_k127_6067929_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 473.0
HFD3_k127_6067929_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003126 411.0
HFD3_k127_6067929_2 membrane insertase activity K03217 GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 321.0
HFD3_k127_6068418_0 Hemerythrin HHE cation binding domain protein K09155 - - 0.000000000000000000000000000001288 126.0
HFD3_k127_6068418_1 Transcriptional regulator K07108 - - 0.00000000000002355 78.0
HFD3_k127_6068418_2 Uncharacterized protein conserved in archaea (DUF2096) - - - 0.000000001591 65.0
HFD3_k127_6091405_0 Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 3.235e-219 696.0
HFD3_k127_6091405_1 PFAM tRNA synthetase, class II (G, H, P and S) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 376.0
HFD3_k127_6091405_2 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 299.0
HFD3_k127_6091405_3 TIGRFAM bifunctional phosphoglucose phosphomannose isomerase K15916 - 5.3.1.8,5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000199 271.0
HFD3_k127_6091405_4 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000002104 213.0
HFD3_k127_6091405_5 Putative RNA methyltransferase K09142 - - 0.00000000000000000000000000000000009752 137.0
HFD3_k127_6094180_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006084 470.0
HFD3_k127_6094180_1 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.000000000000000000000000000000000000000000000000000002104 202.0
HFD3_k127_6094180_2 Transcriptional regulator K07332 - - 0.0000000000000000000007485 104.0
HFD3_k127_609516_0 Phenylalanyl-tRNA synthetase beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006985 466.0
HFD3_k127_609516_1 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 449.0
HFD3_k127_609516_2 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 445.0
HFD3_k127_609516_3 Sigma-54 interaction domain - - - 0.00000000000000001489 87.0
HFD3_k127_609516_4 Belongs to the UPF0337 (CsbD) family - - - 0.000001989 54.0
HFD3_k127_6104823_0 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000008539 238.0
HFD3_k127_6104823_1 protein conserved in archaea K09723 - - 0.0000005274 57.0
HFD3_k127_6104823_2 - - - - 0.00002387 48.0
HFD3_k127_6108832_0 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.000000000000000000000000000000000000000000000000000000006524 206.0
HFD3_k127_6108832_1 PFAM CBS domain - - - 0.0000001568 54.0
HFD3_k127_6157182_0 Nucleotidyl transferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 410.0
HFD3_k127_6157182_1 WxcM-like, C-terminal K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000008302 224.0
HFD3_k127_6157182_2 4,6-dehydratase K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000001701 218.0
HFD3_k127_6166781_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001696 252.0
HFD3_k127_6166781_1 CAAX protease self-immunity K07052 - - 0.0000000000000000000000008288 117.0
HFD3_k127_6166781_2 - - - - 0.0000103 53.0
HFD3_k127_6168828_0 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000002258 274.0
HFD3_k127_6168828_1 Prokaryotic glutathione synthetase, ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000000000000000009993 235.0
HFD3_k127_6168828_2 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000008424 86.0
HFD3_k127_6168828_3 - - - - 0.0000000000006907 79.0
HFD3_k127_6168828_4 Diguanylate cyclase - - - 0.0005863 49.0
HFD3_k127_6183437_0 AAA domain - - - 0.0000000000000000000000000000000000000000003592 170.0
HFD3_k127_6183437_1 PFAM glycosidase PH1107-related K20885 - 2.4.1.339,2.4.1.340 0.000000000000000000000000000000000002349 140.0
HFD3_k127_6185897_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 398.0
HFD3_k127_6185897_1 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001068 280.0
HFD3_k127_6185897_2 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000005979 259.0
HFD3_k127_6185897_3 PFAM aldo keto reductase K07079 - - 0.000000000000000000000000000000000000000000002873 173.0
HFD3_k127_6185897_4 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000001335 161.0
HFD3_k127_6185897_5 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000007611 145.0
HFD3_k127_6185897_6 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000005132 142.0
HFD3_k127_6185897_7 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000006252 122.0
HFD3_k127_6204321_0 PFAM Radical SAM domain protein K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003793 411.0
HFD3_k127_6204321_1 - - - - 0.00000000000000000000000000000000007297 144.0
HFD3_k127_6204321_2 Excinuclease ABC C subunit domain protein K07461 - - 0.000000000000000001491 88.0
HFD3_k127_6204321_3 PFAM phosphatidate cytidylyltransferase - - - 0.0000000000003387 81.0
HFD3_k127_6204321_4 phosphoserine phosphatase K01079 - 3.1.3.3 0.00000343 59.0
HFD3_k127_6217156_0 MOFRL family K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 412.0
HFD3_k127_6217156_1 Flavodoxin-like fold K19784 - - 0.000000000000000000000000000000000000000000000000000000000000000000004734 239.0
HFD3_k127_6217156_2 PFAM S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000000005911 228.0
HFD3_k127_6217156_3 - K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000001912 195.0
HFD3_k127_6217156_4 PFAM TatD-related deoxyribonuclease K03424 - - 0.000000000000000000000000000000000002874 147.0
HFD3_k127_6217156_5 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000007905 99.0
HFD3_k127_6217156_6 TIGRFAM MoaD family protein K03636 - - 0.0000000000001 74.0
HFD3_k127_6217156_7 Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation - - - 0.0000000000005699 74.0
HFD3_k127_6217156_8 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000001247 70.0
HFD3_k127_6236356_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 400.0
HFD3_k127_6236356_1 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000003238 147.0
HFD3_k127_6236356_2 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.0000000000000000000001867 100.0
HFD3_k127_6237495_0 TIGRFAM Arsenical-resistance protein K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004854 297.0
HFD3_k127_6237495_1 Ribosomal protein L11 methyltransferase (PrmA) K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000001571 195.0
HFD3_k127_6237495_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000815 91.0
HFD3_k127_6244533_0 PFAM NADH-ubiquinone oxidoreductase, chain 49kDa - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 396.0
HFD3_k127_6244533_1 PFAM NADH ubiquinone oxidoreductase 20 kDa subunit K14088 - - 0.0000000000000000000000000000000000000000000000000000000000000007915 222.0
HFD3_k127_6244533_2 NADH ubiquinone oxidoreductase subunit 1 (Chain H) K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000244 229.0
HFD3_k127_6244533_3 NADH-Ubiquinone oxidoreductase (complex I), chain 5 K00341,K14086 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000131 188.0
HFD3_k127_6244533_4 PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit K00441,K22174 - 1.1.98.4,1.12.98.1 0.000000000000000000000000000000000000000000006791 182.0
HFD3_k127_6244533_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K14091 - - 0.000000000000000000000001217 109.0
HFD3_k127_6244533_6 NADH ubiquinone oxidoreductase subunit 11 or 4L (chain K) K00340 - 1.6.5.3 0.00000001412 60.0
HFD3_k127_6244533_7 Protein of unknown function (DUF1622) - - - 0.000005344 55.0
HFD3_k127_6244533_8 Belongs to the eukaryotic ribosomal protein eL38 family K02923 - - 0.00004116 48.0
HFD3_k127_6253358_0 PFAM short chain dehydrogenase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000048 276.0
HFD3_k127_6253358_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000007275 222.0
HFD3_k127_6253358_2 Belongs to the UPF0147 family K09721 - - 0.00000000000000000000001525 102.0
HFD3_k127_6253358_3 PFAM Sjogrens syndrome scleroderma autoantigen 1 K07143 - - 0.000000000006645 70.0
HFD3_k127_6263908_0 histidine kinase A domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006291 468.0
HFD3_k127_6273193_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004917 453.0
HFD3_k127_6273193_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000000002439 60.0
HFD3_k127_6282184_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 8.412e-204 649.0
HFD3_k127_6282184_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 337.0
HFD3_k127_6282184_2 TIGRFAM Acetolactate synthase, small subunit K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.000000000000000000000000000000000000000000000000000003206 195.0
HFD3_k127_6293718_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 314.0
HFD3_k127_6293718_1 Protein of unknown function DUF116 K09729 - - 0.00000000000000000000000000000000000000000000000000000000003812 211.0
HFD3_k127_6293718_2 helix_turn_helix, cAMP Regulatory protein - - - 0.000000000000000000000000000000000000009825 149.0
HFD3_k127_6293718_3 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000001842 101.0
HFD3_k127_632337_0 flavodoxin nitric oxide synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 347.0
HFD3_k127_632337_1 Thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000009038 206.0
HFD3_k127_632337_2 YHS domain - - - 0.00000005025 55.0
HFD3_k127_6329941_0 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 580.0
HFD3_k127_6329941_1 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006686 554.0
HFD3_k127_6329941_2 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005599 366.0
HFD3_k127_6329941_3 Catalyzes the reversible conversion of 5-aminoimidazole ribonucleotide (AIR) and CO(2) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000426 154.0
HFD3_k127_6359719_0 PFAM peptidase U32 K08303 - - 0.000000000000001011 79.0
HFD3_k127_6359719_1 PFAM Rhomboid family - - - 0.00000000004401 71.0
HFD3_k127_6359719_2 COG1520 FOG WD40-like repeat - - - 0.0002252 55.0
HFD3_k127_6368984_0 DNA polymerase X family K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 601.0
HFD3_k127_6368984_1 Protein of unknown function, DUF255 K06888 - - 0.000000000000000000000000000000000000000000000000000006733 196.0
HFD3_k127_6368984_2 excinuclease ABC, C subunit - - - 0.0000000000000000000000000000002869 127.0
HFD3_k127_6368984_3 ABC-type multidrug transport system, permease component K01992 - - 0.0000000000000000007769 90.0
HFD3_k127_6368984_4 PFAM GTP cyclohydrolase I K09457 - 1.7.1.13 0.0000002242 58.0
HFD3_k127_6369645_0 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 288.0
HFD3_k127_6369645_1 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000002706 241.0
HFD3_k127_6369645_2 Branched-chain amino acid transport system permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000002111 233.0
HFD3_k127_6369645_3 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000004331 184.0
HFD3_k127_6369645_4 indolepyruvate ferredoxin oxidoreductase beta subunit K00180 - 1.2.7.8 0.00000000000000000000000000000000000001158 151.0
HFD3_k127_6369645_5 Thioesterase superfamily K02614 - - 0.000000000000000000005293 97.0
HFD3_k127_6369645_6 integral membrane protein K07027 - - 0.0002032 51.0
HFD3_k127_6396936_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000003867 151.0
HFD3_k127_6396936_1 COG0328 Ribonuclease HI K03469 - 3.1.26.4 0.0000000000000000000000004708 109.0
HFD3_k127_6396936_2 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000005708 76.0
HFD3_k127_6396936_4 OsmC-like protein - - - 0.000000188 58.0
HFD3_k127_6396936_5 Transcriptional regulator - - - 0.00003019 51.0
HFD3_k127_6396936_6 Hypothetical glycosyl hydrolase family 15 - - - 0.0000375 54.0
HFD3_k127_6402740_0 Protein of unknown function (DUF1073) K09961 - - 0.000000000000007717 87.0
HFD3_k127_6402740_1 PQQ-like domain - - - 0.0000002846 61.0
HFD3_k127_6451036_0 PQQ enzyme repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006664 290.0
HFD3_k127_6451036_1 Virulence factor BrkB K07058 - - 0.00000000000000000000000000000000004182 148.0
HFD3_k127_6451036_2 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000007272 87.0
HFD3_k127_6451036_3 Protein of unknown function (DUF998) - - - 0.00002086 53.0
HFD3_k127_6454749_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005766 473.0
HFD3_k127_6454749_1 TIGRFAM argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 377.0
HFD3_k127_6454749_2 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000001323 100.0
HFD3_k127_6454749_3 Aspartate kinase - - - 0.000000001118 66.0
HFD3_k127_6454749_4 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00007901 46.0
HFD3_k127_6458716_0 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000004393 198.0
HFD3_k127_6458716_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000001357 96.0
HFD3_k127_6458716_2 membrane - - - 0.00000000000000000003923 98.0
HFD3_k127_6468202_0 TIGRFAM LPPG domain protein containing protein K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 349.0
HFD3_k127_6468202_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000007908 254.0
HFD3_k127_6468202_2 Belongs to the eukaryotic ribosomal protein eS1 family K02984 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000002331 216.0
HFD3_k127_6468202_3 MoaE protein K03635 - 2.8.1.12 0.0000000000000000000000008489 109.0
HFD3_k127_6491561_0 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 295.0
HFD3_k127_6491561_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000002652 199.0
HFD3_k127_6542527_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000006689 239.0
HFD3_k127_6542527_1 PFAM Ribonuclease BN-like family K07058 - - 0.00000000000000000000000000000000000000008874 163.0
HFD3_k127_6542527_2 Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000000000000000000001667 158.0
HFD3_k127_6542527_3 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.00000000000000000000000000000000004565 152.0
HFD3_k127_6542527_4 Domain of unknown function (DUF4332) - - - 0.00000000000000000000000003667 118.0
HFD3_k127_6557478_0 Domain of unknown function (DUF296) - - - 0.0000000000000000000000000000000000000000000000000009051 187.0
HFD3_k127_6557478_1 Oxidoreductase molybdopterin binding - - - 0.000000001509 59.0
HFD3_k127_6557478_2 PFAM Glycosyl transferase, family 39 - - - 0.000001387 61.0
HFD3_k127_6557478_3 glycosyl transferase family 39 K00721 - 2.4.1.83 0.00002593 48.0
HFD3_k127_6576476_0 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 GO:0000177,GO:0000178,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575,GO:1902494,GO:1905354 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005475 318.0
HFD3_k127_6576476_1 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 294.0
HFD3_k127_6576476_2 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.00000000000000000000000000000000000000000000000000000000000000008678 231.0
HFD3_k127_6576476_3 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000004313 227.0
HFD3_k127_6576476_4 binds to the 23S rRNA K02921 - - 0.0000000000000000007138 89.0
HFD3_k127_6576476_5 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019773,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000004677 87.0
HFD3_k127_6576476_6 Transcription factor Pcc1 K09741 - - 0.00000008038 57.0
HFD3_k127_6591593_0 Cys/Met metabolism PLP-dependent enzyme K01758,K01761 - 4.4.1.1,4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007305 547.0
HFD3_k127_6591593_1 Pyridoxal-phosphate dependent enzyme K01697 - 4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 461.0
HFD3_k127_6591593_2 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 294.0
HFD3_k127_6591593_3 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007994 253.0
HFD3_k127_6591593_4 O-methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000446 200.0
HFD3_k127_6591593_5 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.00000001208 60.0
HFD3_k127_6597649_0 Amino acid permease K03294 - - 0.0000000000000000000003049 105.0
HFD3_k127_6597649_1 Mechanosensitive ion channel K03442 - - 0.0000000000000000001367 98.0
HFD3_k127_6597649_2 domain protein K03499,K05571 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655 - 0.00000000000000002139 91.0
HFD3_k127_6653738_0 Domain of unknown function (DUF4438) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 355.0
HFD3_k127_6653738_1 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000003912 129.0
HFD3_k127_6653738_2 ribosomal protein K02976 - - 0.000000000000005079 76.0
HFD3_k127_6665424_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000007856 236.0
HFD3_k127_6665424_1 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000003604 220.0
HFD3_k127_6665424_2 peptidase - - - 0.0000000000000000000000000000000000000003046 160.0
HFD3_k127_6686122_0 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002395 328.0
HFD3_k127_6686122_1 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003281 282.0
HFD3_k127_6686122_2 Lipocalin-like domain K03098 - - 0.000000000000000000000000002168 112.0
HFD3_k127_6686122_3 CBS domain - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000001773 51.0
HFD3_k127_6688027_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002083 606.0
HFD3_k127_6688027_1 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000007298 250.0
HFD3_k127_6688027_2 Ser thr protein kinase K07176 - - 0.0000000000000000000000000000000000000000000000000006402 192.0
HFD3_k127_6688027_3 Conserved protein implicated in secretion - - - 0.0000000000000000000000000000000000000117 153.0
HFD3_k127_6716121_0 Glycogen debranching enzyme N terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006329 471.0
HFD3_k127_6716121_1 galactose-1-phosphate uridylyltransferase K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000001268 271.0
HFD3_k127_6728936_0 Cation transporter/ATPase, N-terminus K01531,K01535,K01537,K12952 - 3.6.3.2,3.6.3.6,3.6.3.8 5.871e-219 708.0
HFD3_k127_6728936_1 Protein of unknown function (DUF3795) - - - 0.000000000000000000000000000000000000000000000000000000000000000936 224.0
HFD3_k127_6777122_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.000000000000000000000000000000000000000000005364 167.0
HFD3_k127_6777122_1 - - - - 0.00000000000000000001257 95.0
HFD3_k127_678717_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0000049,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0097159,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 1.261e-235 757.0
HFD3_k127_678717_1 Domain of unknown function DUF120 K07732 - 2.7.1.161 0.000000000000000000000000000000000000000000000000304 184.0
HFD3_k127_678717_2 Domain of unknown function (DUF373) K08975 - - 0.00000000000000000000000000000000000000000000001815 186.0
HFD3_k127_678717_3 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005515,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009161,GO:0009165,GO:0009259,GO:0009987,GO:0010181,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042726,GO:0042727,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046443,GO:0046444,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072387,GO:0072388,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.7.2 0.00000000000000000000000000000001828 130.0
HFD3_k127_678717_4 Rhomboid family K19225 - 3.4.21.105 0.00000000000000000000000000005384 124.0
HFD3_k127_678717_5 archaeal coiled-coil protein - - - 0.0000000000000000000000001984 117.0
HFD3_k127_6841294_0 SMART Elongator protein 3 MiaB NifB K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000908 306.0
HFD3_k127_6841294_1 PQQ enzyme repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007516 293.0
HFD3_k127_6841294_2 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000006368 156.0
HFD3_k127_686555_0 S-layer homology domain - - - 0.0000000000000007964 85.0
HFD3_k127_686555_1 - - - - 0.0000000000005755 71.0
HFD3_k127_686555_2 - - - - 0.00004485 56.0
HFD3_k127_6892947_0 transcriptional regulator K03719 - - 0.0000000004591 67.0
HFD3_k127_6892947_1 helix_turn_helix ASNC type K03718 - - 0.0000000004744 66.0
HFD3_k127_6948581_0 Male sterility protein K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000000000000000002607 254.0
HFD3_k127_6948581_1 PFAM Nucleotidyl transferase K00973 - 2.7.7.24 0.000000000000000005501 85.0
HFD3_k127_6948581_2 Glycosyl transferase family 21 - - - 0.000007041 56.0
HFD3_k127_6948581_3 Nodulation protein S (NodS) - - - 0.0000682 52.0
HFD3_k127_695027_0 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000000000000000000003696 167.0
HFD3_k127_695027_1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000001301 121.0
HFD3_k127_6959749_0 PHP domain protein K01183 - 3.2.1.14 0.0000000000000000000000000000000000000000000000000000005288 211.0
HFD3_k127_6959749_1 COG1680 Beta-lactamase class C and other penicillin binding - - - 0.00000000000000000000000001355 113.0
HFD3_k127_6959749_2 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K15893 - 1.1.1.26 0.0000000000000000000000008046 107.0
HFD3_k127_6964165_0 synthetase (ADP forming), alpha K01905,K09181,K22224 GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564 6.2.1.13 1.367e-240 774.0
HFD3_k127_6964165_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 601.0
HFD3_k127_6964165_10 cytochrome-c peroxidase activity - - - 0.0000000000001497 79.0
HFD3_k127_6964165_11 Sterol carrier protein - - - 0.000000000041 67.0
HFD3_k127_6964165_12 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.0000008271 54.0
HFD3_k127_6964165_13 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.00001236 54.0
HFD3_k127_6964165_14 Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser Thr consensus motif in nascent polypeptide chains K12666 GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005791,GO:0005829,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0008250,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0015833,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0031410,GO:0031982,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0042470,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048770,GO:0051179,GO:0051234,GO:0070085,GO:0071702,GO:0071704,GO:0071705,GO:0097708,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990234 - 0.0001732 54.0
HFD3_k127_6964165_2 Starch synthase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 457.0
HFD3_k127_6964165_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005111 432.0
HFD3_k127_6964165_4 Glutamate-cysteine ligase family 2(GCS2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 335.0
HFD3_k127_6964165_5 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000009424 232.0
HFD3_k127_6964165_6 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000001816 221.0
HFD3_k127_6964165_7 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000006107 117.0
HFD3_k127_6964165_8 Uncharacterized protein conserved in archaea (DUF2095) - - - 0.0000000000000000000345 94.0
HFD3_k127_6964165_9 4Fe-4S binding domain - - - 0.00000000000002322 74.0
HFD3_k127_6994861_0 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000001536 87.0
HFD3_k127_6998381_0 Belongs to the MCM family K10726 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000418 565.0
HFD3_k127_6998381_1 4Fe-4S single cluster domain K06937 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008178 538.0
HFD3_k127_6998381_10 S25 ribosomal protein K02975 - - 0.00000001294 60.0
HFD3_k127_6998381_11 GINS complex protein K09723 - - 0.000008079 55.0
HFD3_k127_6998381_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 472.0
HFD3_k127_6998381_3 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 381.0
HFD3_k127_6998381_4 Translation initiation factor 2 K03237 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000005756 213.0
HFD3_k127_6998381_5 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000005125 179.0
HFD3_k127_6998381_6 Archaeal transcriptional regulator TrmB - - - 0.000000000000000000000000000000000000000000004911 172.0
HFD3_k127_6998381_7 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000005094 115.0
HFD3_k127_6998381_8 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.00000000000000000235 85.0
HFD3_k127_6998381_9 PFAM Ribosomal protein S27E K02978 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000844 76.0
HFD3_k127_7006970_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008509 368.0
HFD3_k127_7006970_1 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007207 324.0
HFD3_k127_7006970_2 Fumarate hydratase K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 309.0
HFD3_k127_7006970_3 Fe-S type, tartrate fumarate subfamily, beta K01676,K01678,K03780 - 4.2.1.2,4.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000002024 226.0
HFD3_k127_7006970_4 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 2.3.1.128 0.00000000000000000000000000000000000000000004763 165.0
HFD3_k127_7024935_0 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000002896 168.0
HFD3_k127_7024935_1 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 GO:0003674,GO:0003824,GO:0003999,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006168,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009113,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.7 0.00000000000000000000000000004017 118.0
HFD3_k127_7024935_2 ACT domain K09707 - - 0.0000000000000001307 84.0
HFD3_k127_7024935_3 Transcriptional regulator PadR-like family - - - 0.000000000006382 71.0
HFD3_k127_7024935_4 PFAM SNARE associated Golgi protein - - - 0.00000000001595 72.0
HFD3_k127_7037002_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 366.0
HFD3_k127_7037002_1 PFAM CBS domain containing protein - - - 0.000000000000000001073 91.0
HFD3_k127_7037002_2 - - - - 0.00000000000002999 77.0
HFD3_k127_7050000_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008101 485.0
HFD3_k127_7050000_1 Belongs to the V-ATPase 116 kDa subunit family K02123 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006873,GO:0006885,GO:0007035,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019725,GO:0019829,GO:0019899,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042592,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0045851,GO:0046034,GO:0046390,GO:0046483,GO:0046961,GO:0048878,GO:0050801,GO:0051117,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0055086,GO:0065007,GO:0065008,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000004407 192.0
HFD3_k127_7050000_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000002316 112.0
HFD3_k127_7050000_3 ATP synthase (E/31 kDa) subunit - - - 0.000000001413 66.0
HFD3_k127_7050000_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.000001171 54.0
HFD3_k127_7111113_0 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 383.0
HFD3_k127_7111113_1 DNA primase K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 357.0
HFD3_k127_7111113_2 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 GO:0000956,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0034655,GO:0034660,GO:0034661,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0070651,GO:0070966,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903008 - 0.0000000000000000000000000000000000000000000000000000000000000001184 234.0
HFD3_k127_7111113_3 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000001198 227.0
HFD3_k127_7111113_4 PadR family transcriptional regulator - - - 0.00000001402 61.0
HFD3_k127_7111113_5 Protein of unknown function (DUF996) - - - 0.00000002467 64.0
HFD3_k127_7111113_6 Metallo-beta-lactamase superfamily K12574 - - 0.000009475 49.0
HFD3_k127_7111113_7 transcriptional regulator PadR family K10947 - - 0.00002207 51.0
HFD3_k127_7111113_8 protein phosphatase regulator activity K06276,K11584 - 2.7.11.1 0.0003856 53.0
HFD3_k127_7111113_9 5'-3' exoribonuclease activity K12574 - - 0.0008007 44.0
HFD3_k127_7115548_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000006603 216.0
HFD3_k127_7115548_1 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000000000000000000000005563 213.0
HFD3_k127_7115548_2 PFAM D-isomer specific 2-hydroxyacid dehydrogenase catalytic region K00015,K00058,K16843 - 1.1.1.26,1.1.1.310,1.1.1.399,1.1.1.95 0.000000000000000000000000000000000004536 141.0
HFD3_k127_7115548_3 spore germination K00442,K08315 - 3.4.23.51 0.000000000000000000000003525 108.0
HFD3_k127_7115548_4 Nickel-dependent hydrogenase K14126 - 1.8.98.5 0.0000009344 50.0
HFD3_k127_7134726_0 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004753 362.0
HFD3_k127_7134726_1 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.000000000000000000000000000000000000000000000000000000000000000000000005176 250.0
HFD3_k127_7134726_2 H4MPT-linked C1 transfer pathway protein K07072 - 2.5.1.131 0.000000000000000000000000000000000000000000000000000000000003165 217.0
HFD3_k127_7134726_3 Pfam ATP-grasp domain K06914 - 6.3.4.24 0.000000000000000000000000000000000000000000009668 178.0
HFD3_k127_7138687_0 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000001912 185.0
HFD3_k127_7138687_1 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.00002387 48.0
HFD3_k127_71700_0 COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis K07332 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 453.0
HFD3_k127_71700_1 type II secretion system protein - - - 0.000000000000000000003757 104.0
HFD3_k127_71700_2 Type II secretion system K07333 - - 0.00000000000000001071 88.0
HFD3_k127_71700_3 TIGRFAM archaeal flagellin N-terminal-like domain - - - 0.00003448 53.0
HFD3_k127_7179796_0 CoA binding domain K01905,K09181,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 554.0
HFD3_k127_7179796_1 PFAM Nickel-dependent hydrogenase, large subunit K00436,K14126,K17993 - 1.12.1.2,1.12.1.3,1.12.1.5,1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000004578 244.0
HFD3_k127_7219808_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004237 404.0
HFD3_k127_7219808_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 383.0
HFD3_k127_7219808_10 PFAM Collagen triple helix - - - 0.0000000008874 69.0
HFD3_k127_7219808_2 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002516 373.0
HFD3_k127_7219808_3 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 287.0
HFD3_k127_7219808_4 TIGRFAM archaeoflavoprotein AfpA - - - 0.000000000000000000000000000000000000000000000000000000000001721 214.0
HFD3_k127_7219808_5 PAC2 family K07159 - - 0.0000000000000000000000000000000000000004474 158.0
HFD3_k127_7219808_6 metallopeptidase activity K06974 - - 0.0000000000000000000000000000000000004095 146.0
HFD3_k127_7219808_7 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000002825 104.0
HFD3_k127_7219808_8 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000008069 105.0
HFD3_k127_7219808_9 protein conserved in archaea - - - 0.000000000000005916 85.0
HFD3_k127_7241044_0 Histidine kinase-like ATPases - - - 0.0000000000000000000000000000000000000000001111 176.0
HFD3_k127_7241044_1 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000001166 85.0
HFD3_k127_7259831_0 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000004202 174.0
HFD3_k127_7259831_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000003484 117.0
HFD3_k127_7259831_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000001906 111.0
HFD3_k127_7276618_0 DNA primase activity K06919,K17680 - 3.6.4.12 0.00000000006856 76.0
HFD3_k127_7303891_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.000000000000000000000000000000000000000000000000000000000000000000001175 240.0
HFD3_k127_7303891_1 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000002072 124.0
HFD3_k127_7303891_2 Major Facilitator Superfamily - - - 0.000003411 54.0
HFD3_k127_7313114_0 Putative undecaprenyl diphosphate synthase K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000001102 257.0
HFD3_k127_7313114_1 Acetyltransferase (GNAT) domain - - - 0.000000000000004507 82.0
HFD3_k127_7313114_2 Carboxypeptidase - - - 0.00001974 56.0
HFD3_k127_7391100_0 Beta-eliminating lyase K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 322.0
HFD3_k127_7391100_1 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001853 287.0
HFD3_k127_7391100_2 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis - - - 0.000000003015 58.0
HFD3_k127_743143_0 Pfam:Methyltransf_26 K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000006442 171.0
HFD3_k127_743143_1 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000005087 161.0
HFD3_k127_743143_2 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000005627 91.0
HFD3_k127_743143_3 - - - - 0.00000000000002992 72.0
HFD3_k127_743295_0 PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein K01740 - 2.5.1.49 5.999e-213 668.0
HFD3_k127_743295_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 536.0
HFD3_k127_743295_2 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000964 427.0
HFD3_k127_743295_3 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006031 291.0
HFD3_k127_743295_4 haloacid dehalogenase-like hydrolase K01533 - 3.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000001426 274.0
HFD3_k127_743295_5 methyltransferase K00641 - 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000001255 218.0
HFD3_k127_743295_6 methyltransferase activity - - - 0.0000005779 57.0
HFD3_k127_7463236_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 4.912e-308 973.0
HFD3_k127_7463236_1 PFAM chaperonin Cpn60 TCP-1 K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0042802,GO:0044183,GO:0051082,GO:0061077 - 2.39e-205 652.0
HFD3_k127_7463236_10 - - - - 0.00000000000000000008078 97.0
HFD3_k127_7463236_11 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006457,GO:0006996,GO:0007010,GO:0008150,GO:0009987,GO:0016043,GO:0044424,GO:0044464,GO:0071840 - 0.000000000000000001209 90.0
HFD3_k127_7463236_12 PFAM Glycosyl transferase family 4 K01001 - 2.7.8.15 0.000000000000001427 87.0
HFD3_k127_7463236_14 DREV methyltransferase - - - 0.000004138 57.0
HFD3_k127_7463236_15 - - - - 0.00001405 48.0
HFD3_k127_7463236_2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007014 577.0
HFD3_k127_7463236_3 HELICc2 K10844 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 368.0
HFD3_k127_7463236_4 ABC-type cobalt transport system ATPase component K16787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 302.0
HFD3_k127_7463236_5 ATP-binding protein K16786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000365 256.0
HFD3_k127_7463236_6 co-translational protein modification K07151 GO:0003674,GO:0003824,GO:0004576,GO:0004579,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006807,GO:0008150,GO:0008152,GO:0008250,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0031984,GO:0032991,GO:0034645,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0043686,GO:0043687,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0070085,GO:0071704,GO:0098796,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990234 2.4.99.18 0.00000000000000000000000000000000000000000000000000000000000008191 239.0
HFD3_k127_7463236_7 DHH family - - - 0.00000000000000000000000000000000000000000000001395 183.0
HFD3_k127_7463236_8 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000000000000000000000000000000000001114 144.0
HFD3_k127_7463236_9 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000001378 109.0
HFD3_k127_7504723_0 With S4 and S12 plays an important role in translational accuracy K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002842 261.0
HFD3_k127_7504723_1 Belongs to the eukaryotic ribosomal protein eS4 family K02987 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000002957 240.0
HFD3_k127_7504723_10 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000000000000005076 139.0
HFD3_k127_7504723_11 binds to the 23S rRNA K02885 - - 0.0000000000000000000000000000000002129 137.0
HFD3_k127_7504723_12 Located at the polypeptide exit tunnel on the outside of the subunit K02895 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000002125 140.0
HFD3_k127_7504723_13 Belongs to the eukaryotic ribosomal protein eL32 family K02912 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000004955 132.0
HFD3_k127_7504723_14 Binds 16S rRNA, required for the assembly of 30S particles K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008270,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:1990904 - 0.0000000000000000005584 87.0
HFD3_k127_7504723_15 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 GO:0000172,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005732,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000003904 68.0
HFD3_k127_7504723_16 RDD family - - - 0.000000002646 64.0
HFD3_k127_7504723_17 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000004291 56.0
HFD3_k127_7504723_2 Binds the lower part of the 30S subunit head K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000001533 232.0
HFD3_k127_7504723_3 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000001832 213.0
HFD3_k127_7504723_4 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000275 206.0
HFD3_k127_7504723_5 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000002395 198.0
HFD3_k127_7504723_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000000003291 178.0
HFD3_k127_7504723_7 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000008542 175.0
HFD3_k127_7504723_8 Ribosomal protein L30p/L7e K02907 GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000001075 159.0
HFD3_k127_7504723_9 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000001301 147.0
HFD3_k127_7518456_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 442.0
HFD3_k127_7518456_1 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 430.0
HFD3_k127_7518456_2 phosphoesterase RecJ domain protein K07463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009454 273.0
HFD3_k127_7518456_3 - - - - 0.0000000007154 62.0
HFD3_k127_7548086_0 PFAM type II secretion system protein E K07332 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002882 539.0
HFD3_k127_7548086_1 PFAM type II secretion system K07333 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 324.0
HFD3_k127_7548086_2 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000001338 209.0
HFD3_k127_7548086_3 sh3 domain protein - - - 0.00000000000000001076 98.0
HFD3_k127_7559963_0 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000001385 136.0
HFD3_k127_7559963_1 - - - - 0.0000000000000000000000000000004779 124.0
HFD3_k127_7559963_2 PQQ-like domain K00114 - 1.1.2.8 0.00000001467 68.0
HFD3_k127_7567287_0 PFAM beta-lactamase domain protein K07041 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004081 327.0
HFD3_k127_7567287_1 PFAM Appr-1-p processing - - - 0.0000000000000000000000000000000000000000000000000000000000001281 217.0
HFD3_k127_7567287_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000009795 210.0
HFD3_k127_7577105_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002946 293.0
HFD3_k127_7577105_1 helix_turn_helix ASNC type - - - 0.00000000000000000000000000000000000000000000000000001197 192.0
HFD3_k127_7577105_2 - - - - 0.000000000000000006307 96.0
HFD3_k127_7582335_1 Fibronectin-binding A domain protein - - - 0.0000000000000003939 82.0
HFD3_k127_7582335_2 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.000002841 50.0
HFD3_k127_7582335_3 - - - - 0.000004944 54.0
HFD3_k127_7583888_0 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009606 556.0
HFD3_k127_7583888_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K11131 GO:0000154,GO:0000495,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016556,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031120,GO:0031123,GO:0031126,GO:0033979,GO:0034470,GO:0034641,GO:0034660,GO:0034964,GO:0040031,GO:0042254,GO:0043144,GO:0043170,GO:0043412,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990481 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 364.0
HFD3_k127_7583888_2 tRNA (Uracil-5-)-methyltransferase - - - 0.00000000000000000000000000000000000000000000004253 177.0
HFD3_k127_7583888_3 Belongs to the eukaryotic ribosomal protein eL14 family K02875 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000002927 119.0
HFD3_k127_7583888_4 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000002114 106.0
HFD3_k127_7583888_5 retrograde transport, endosome to Golgi - - - 0.000000000000000000000009563 104.0
HFD3_k127_7601941_0 SnoaL-like polyketide cyclase - - - 0.00000000000000005235 86.0
HFD3_k127_7607157_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006448 424.0
HFD3_k127_7607157_1 Belongs to the MEMO1 family K06990 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 289.0
HFD3_k127_7607157_2 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000203 295.0
HFD3_k127_7607157_3 Belongs to the universal ribosomal protein uS2 family K02967 GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000008184 253.0
HFD3_k127_7607157_4 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009633 245.0
HFD3_k127_7607157_5 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000000000000000003228 138.0
HFD3_k127_7607157_6 Protein of unknown function DUF72 - - - 0.00000000001266 75.0
HFD3_k127_7612727_0 methyltransferase - - - 0.00000000000000000000000000000000000000000000003957 173.0
HFD3_k127_7612727_1 nitrogen fixation - - - 0.0000000000000000000000001919 111.0
HFD3_k127_7612727_2 PFAM transcriptional regulator TrmB - - - 0.0000000000004811 81.0
HFD3_k127_7612727_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0001167 48.0
HFD3_k127_7614478_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 514.0
HFD3_k127_7626145_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 GO:0000150,GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0000730,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0033554,GO:0034622,GO:0034641,GO:0042148,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0045003,GO:0046483,GO:0050896,GO:0051716,GO:0065003,GO:0065004,GO:0071704,GO:0071824,GO:0071840,GO:0090304,GO:0090735,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.0000000000005352 78.0
HFD3_k127_7630328_0 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000001436 251.0
HFD3_k127_7630328_1 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000001056 232.0
HFD3_k127_7630328_2 nucleotide-binding protein - - - 0.00000000000000000000000000000000453 134.0
HFD3_k127_7630328_3 flavodoxin K00230 - 1.3.5.3 0.0000000000000000000000000000002785 129.0
HFD3_k127_7630328_4 all-trans-retinol 13,14-reductase activity - - - 0.000000000000000000000000000008132 120.0
HFD3_k127_7630328_5 Protein of unknown function (DUF998) - - - 0.0000000000000000001007 97.0
HFD3_k127_7630328_6 Transmembrane secretion effector - - - 0.000000007603 59.0
HFD3_k127_7632147_0 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 1.085e-198 637.0
HFD3_k127_7632147_1 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007418 378.0
HFD3_k127_7632147_2 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000001192 255.0
HFD3_k127_7632147_3 - - - - 0.0000000000000000000000000000000000004552 147.0
HFD3_k127_7632147_4 Flavin reductase like domain - - - 0.0000000000000000000000000000000000007132 145.0
HFD3_k127_7643214_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 310.0
HFD3_k127_7643214_1 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0009451,GO:0009987,GO:0016070,GO:0016740,GO:0016741,GO:0032259,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000008203 232.0
HFD3_k127_7643214_2 - - - - 0.0000000001452 69.0
HFD3_k127_7643214_3 COG1522 Transcriptional regulators - - - 0.000000003354 63.0
HFD3_k127_7643214_4 family 28 C-terminal - - - 0.0003912 43.0
HFD3_k127_7646734_0 AMMECR1 K09141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001139 245.0
HFD3_k127_7646734_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000001399 210.0
HFD3_k127_7646734_2 Nicotinamide-nucleotide adenylyltransferase K00952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.7.1 0.000000000000000000000000000000000000000000000000000003317 195.0
HFD3_k127_7646734_3 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.0000000000001386 80.0
HFD3_k127_7646734_4 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 0.0000000000008535 73.0
HFD3_k127_7669097_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005663,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000457 228.0
HFD3_k127_7669097_1 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000000000003927 216.0
HFD3_k127_7669097_2 Endonuclease V K05982 - 3.1.21.7 0.0000000000000000000000000000000000000000000001616 175.0
HFD3_k127_7669097_3 PFAM Translin K07477 - - 0.00000000000000000000000000006203 125.0
HFD3_k127_7669097_4 methionyl-tRNA aminoacylation K01874,K01890,K06878 GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10,6.1.1.20 0.00000000000000000000000001311 112.0
HFD3_k127_7674503_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000848 423.0
HFD3_k127_7674503_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004848 273.0
HFD3_k127_7674503_2 thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000001799 165.0
HFD3_k127_7674503_3 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000003317 167.0
HFD3_k127_7674503_4 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000003128 114.0
HFD3_k127_7674503_5 Domain of unknown function (DUF4382) - - - 0.00000000471 64.0
HFD3_k127_7674503_6 regulatory protein, arsR - - - 0.00000001712 61.0
HFD3_k127_7674503_8 ATP cone domain - - - 0.0003248 47.0
HFD3_k127_7676329_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 1.141e-195 617.0
HFD3_k127_7676329_1 ERCC4 domain K10896 - - 0.0000000000000000000000000000000191 135.0
HFD3_k127_7726126_0 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000027 283.0
HFD3_k127_7726126_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.00001281 53.0
HFD3_k127_7742058_0 PFAM chaperonin Cpn60 TCP-1 K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0042802,GO:0044183,GO:0051082,GO:0061077 - 8.216e-207 656.0
HFD3_k127_7742058_1 PFAM TCP-1 cpn60 chaperonin family K22447 - - 1.792e-204 650.0
HFD3_k127_7742058_2 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000005729 196.0
HFD3_k127_7742058_3 Chemotaxis K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000001843 138.0
HFD3_k127_77937_0 PFAM Sugar isomerase (SIS) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002163 290.0
HFD3_k127_77937_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007942 285.0
HFD3_k127_77937_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000003991 185.0
HFD3_k127_77937_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000001203 111.0
HFD3_k127_77937_4 - - - - 0.000000002195 64.0
HFD3_k127_77937_5 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.00000005669 59.0
HFD3_k127_789726_0 aconitate hydratase K01681 - 4.2.1.3 1.638e-277 867.0
HFD3_k127_789726_1 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 478.0
HFD3_k127_789726_2 PFAM ABC transporter transmembrane region K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008763 363.0
HFD3_k127_789726_3 Multidrug ABC transporter, ATP-binding protein K02021,K06147 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0071702 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005699 288.0
HFD3_k127_789726_4 ABC transporter transmembrane region K06147 - - 0.000000000000000000000000000000000000333 154.0
HFD3_k127_789932_0 Dolichyl-phosphate beta-D-mannosyltransferase K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000005675 187.0
HFD3_k127_789932_1 PFAM Glycosyl transferase family 2 K19003 - 2.4.1.336 0.00000000000000000000000000000000028 140.0
HFD3_k127_789932_2 Predicted membrane protein (DUF2079) - - - 0.0000000002549 66.0
HFD3_k127_821002_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1381.0
HFD3_k127_821002_1 Participates in transcription termination K02600 - - 0.00000000000000000000000000000385 121.0
HFD3_k127_821002_2 Belongs to the eukaryotic ribosomal protein eL30 family K02908 - - 0.000000000000000000000003112 105.0
HFD3_k127_822881_0 kinase, sugar kinase superfamily K06982 - 2.7.1.169 0.00000000000000000000000000000000000000000000008679 181.0
HFD3_k127_822881_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K02201 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.000000000000000000000000000000000009917 141.0
HFD3_k127_822881_2 - - - - 0.00000000000000000000000003935 117.0
HFD3_k127_822881_3 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity K00549 - 2.1.1.14 0.000000000000000000000004964 112.0
HFD3_k127_822881_4 Belongs to the peptidase M10A family K07761,K07999 GO:0001101,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009628,GO:0009651,GO:0009719,GO:0009725,GO:0009753,GO:0010033,GO:0010035,GO:0010038,GO:0016020,GO:0016787,GO:0019538,GO:0031224,GO:0031225,GO:0032502,GO:0040007,GO:0042221,GO:0043170,GO:0044238,GO:0044425,GO:0044464,GO:0046686,GO:0048519,GO:0048580,GO:0048583,GO:0048589,GO:0048831,GO:0050789,GO:0050793,GO:0050896,GO:0051093,GO:0051239,GO:0051241,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080186,GO:0140096,GO:1900055,GO:1900056,GO:1901564,GO:1901700,GO:1905622,GO:2000024,GO:2000026,GO:2000028,GO:2000241 - 0.0000003792 61.0
HFD3_k127_823998_0 Catalyzes the oxidation of methylene-H(4)MPT to methenyl-H(4)MPT( ) K00319 - 1.5.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 303.0
HFD3_k127_823998_1 glutamyl-tRNA reductase activity K02407,K02492,K10714,K15671 GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000002996 226.0
HFD3_k127_839805_0 DNA Topoisomerase I (eukaryota) K03163 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 360.0
HFD3_k127_839805_1 - - - - 0.0000000000000000000000002067 110.0
HFD3_k127_839805_2 Transcriptional regulator, TrmB - - - 0.000000002443 63.0
HFD3_k127_839805_3 Belongs to the UPF0235 family K09131 - - 0.000000003385 61.0
HFD3_k127_839805_4 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 - - - 0.000008779 54.0
HFD3_k127_850422_0 PFAM Amidohydrolase 3 K00200 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 608.0
HFD3_k127_850422_1 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 477.0
HFD3_k127_850422_10 PFAM DsrE family protein K07235 - - 0.000000000000000000000000004414 114.0
HFD3_k127_850422_11 PFAM DNA polymerase, beta domain protein region K09717 - - 0.000000000000000000004035 105.0
HFD3_k127_850422_12 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.0000000000000000003484 94.0
HFD3_k127_850422_13 vacuolar transport - - - 0.0000000000000000004669 98.0
HFD3_k127_850422_14 PFAM SirA family protein K04085 GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008 - 0.00000000000001334 76.0
HFD3_k127_850422_15 - - - - 0.00000000001805 73.0
HFD3_k127_850422_16 - K09717 - - 0.0000001036 64.0
HFD3_k127_850422_2 AAA domain (Cdc48 subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 437.0
HFD3_k127_850422_3 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001173 289.0
HFD3_k127_850422_4 ATP dephospho-CoA triphosphoribosyl transferase K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000006281 198.0
HFD3_k127_850422_5 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.00000000000000000000000000000000000000000000000000456 190.0
HFD3_k127_850422_6 DNA polymerase beta domain protein region K09717 - - 0.0000000000000000000000000000000000000000000003623 179.0
HFD3_k127_850422_7 conserved protein implicated in secretion - - - 0.000000000000000000000000000000000000000000008755 171.0
HFD3_k127_850422_8 Acyltransferase family - - - 0.000000000000000000000000000000000000006155 159.0
HFD3_k127_850422_9 PFAM molydopterin dinucleotide-binding region K00203 - 1.2.7.12 0.000000000000000000000000000001845 126.0
HFD3_k127_880298_0 Belongs to the RtcB family K14415 GO:0000394,GO:0003674,GO:0003824,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360 6.5.1.3 2.988e-203 643.0
HFD3_k127_880298_1 M42 glutamyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003332 363.0
HFD3_k127_880298_2 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000002429 214.0
HFD3_k127_880298_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000006589 201.0
HFD3_k127_880298_4 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.000000000000000000000000000000000007237 141.0
HFD3_k127_880298_5 Major Facilitator Superfamily - - - 0.00000000000000000000003865 113.0
HFD3_k127_880298_6 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0001305 53.0
HFD3_k127_88653_0 helicase superfamily c-terminal domain K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 395.0
HFD3_k127_88653_1 Subtilase family K13276,K17734 - - 0.00000000000000000000000005332 126.0
HFD3_k127_88653_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0000001422 54.0
HFD3_k127_928177_0 snRNP Sm proteins K04796 - - 0.0000000000000000005275 91.0
HFD3_k127_928177_1 binds to the 23S rRNA K02922 - - 0.0000000000000001367 80.0
HFD3_k127_928177_2 - - - - 0.000000000004841 74.0
HFD3_k127_928177_3 glycolate biosynthetic process K01091 - 3.1.3.18 0.000000007847 58.0
HFD3_k127_93224_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 456.0
HFD3_k127_936867_0 Glycosyltransferase family 28 N-terminal domain K05841 - 2.4.1.173 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004825 518.0
HFD3_k127_936867_1 Bacterio-opsin activator HTH K06930 - - 0.0000000000000000000007077 103.0
HFD3_k127_936867_2 Phage integrase, N-terminal SAM-like domain K16898 - 3.6.4.12 0.000000005908 64.0
HFD3_k127_937450_0 Participates in transcription termination K02600 - - 0.0000000000000000000002259 98.0
HFD3_k127_937450_1 AAA domain - - - 0.00000000000000002507 96.0
HFD3_k127_937450_2 RecF/RecN/SMC N terminal domain - - - 0.00000000000000002507 96.0
HFD3_k127_967507_0 zinc finger - - - 0.000000000000000000000000000000000000000000008526 173.0
HFD3_k127_967507_1 Involved in the binding of tRNA to the ribosomes K02946 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000005743 144.0
HFD3_k127_967507_2 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000001428 136.0
HFD3_k127_967507_3 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K04763 - - 0.00000000176 70.0
HFD3_k127_967507_4 Periplasmic copper-binding protein (NosD) - - - 0.000000005237 67.0
HFD3_k127_967507_5 Transcriptional regulator - - - 0.0000001258 59.0
HFD3_k127_967507_6 AAA domain - - - 0.0000004174 64.0
HFD3_k127_967507_7 metallocarboxypeptidase activity. It is involved in the biological process described with proteolysis K01290,K01298 GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0005575,GO:0005576,GO:0005615,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044421,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.17.15 0.0002722 51.0
HFD3_k127_98608_0 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000529 265.0
HFD3_k127_98608_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.0000000000000000000000000000004483 133.0
HFD3_k127_99672_0 Contains one ATP-binding region, ATPase-like domain (IPR003594) K07652 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000008991 218.0
HFD3_k127_99672_1 NMT1-like family K02051 - - 0.0000000000000001257 82.0
HFD3_k127_99672_2 Histidine kinase - - - 0.00002933 56.0
HFD3_k127_998205_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 2.887e-291 910.0
HFD3_k127_998205_1 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 392.0
HFD3_k127_998205_2 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005222 310.0
HFD3_k127_998205_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000001503 234.0
HFD3_k127_998205_4 Nicotinamide-nucleotide adenylyltransferase K00952 - 2.7.7.1 0.000000000000000000000000000000000000000000000000000513 189.0
HFD3_k127_998205_5 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000004854 192.0
HFD3_k127_998205_6 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K04794 - 3.1.1.29 0.000000000000000000000000000000000001547 142.0
HFD3_k127_998205_7 Domain of unknown function (DUF1610) K07580 - - 0.0000000000000003057 80.0
HFD3_k127_998205_8 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000001956 64.0
HFD3_k127_998205_9 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0000000001998 61.0
HFD3_k127_998945_0 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000817 184.0
HFD3_k127_998945_1 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.000001536 58.0
HFD3_k127_998945_2 - - - - 0.00005411 55.0