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Overview

ID MAG01726
Name HKD1_bin.43
Sample SMP0046
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Steroidobacterales
Family Steroidobacteraceae
Genus FEN-1191
Species
Assembly information
Completeness (%) 100.0
Contamination (%) 0.74
GC content (%) 70.0
N50 (bp) 58,968
Genome size (bp) 3,017,696

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2780

Gene name Description KEGG GOs EC E-value Score Sequence
HKD1_k127_1003241_0 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 3.34e-284 889.0
HKD1_k127_1003241_1 benzoyl-CoA oxygenase K15512 - 1.14.13.208 9.958e-272 847.0
HKD1_k127_1003241_10 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K12256 - 2.6.1.113 2.705e-203 650.0
HKD1_k127_1003241_11 belongs to the aldehyde dehydrogenase family - - - 3.504e-200 659.0
HKD1_k127_1003241_12 protein related to plant photosystem II stability assembly factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 605.0
HKD1_k127_1003241_13 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002636 600.0
HKD1_k127_1003241_14 Oxidoreductase NAD-binding domain K15511 - 1.14.13.208 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 560.0
HKD1_k127_1003241_15 Transcriptional regulator, XRE family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 556.0
HKD1_k127_1003241_16 ATPases associated with a variety of cellular activities K10441 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 568.0
HKD1_k127_1003241_17 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 542.0
HKD1_k127_1003241_18 Cobalamin-independent synthase, Catalytic domain K00549,K22363 - 2.1.1.14,4.4.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001953 534.0
HKD1_k127_1003241_19 H( )-stimulated, divalent metal cation uptake system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 535.0
HKD1_k127_1003241_2 enoyl-CoA hydratase K15513 - 4.1.2.44 1.039e-266 844.0
HKD1_k127_1003241_20 protein conserved in bacteria K09989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000353 525.0
HKD1_k127_1003241_21 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K03502 GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005176 513.0
HKD1_k127_1003241_22 Phenylacetic acid catabolic protein K02609 - 1.14.13.149 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 503.0
HKD1_k127_1003241_23 C-terminus of AA_permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 499.0
HKD1_k127_1003241_24 E COG0620 Methionine synthase II (cobalamin-independent) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 494.0
HKD1_k127_1003241_25 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 482.0
HKD1_k127_1003241_26 ATPase associated with various cellular activities, AAA_5 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006013 469.0
HKD1_k127_1003241_27 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 474.0
HKD1_k127_1003241_28 Periplasmic binding protein domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007606 430.0
HKD1_k127_1003241_29 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 434.0
HKD1_k127_1003241_3 Aldehyde dehydrogenase K02618 GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016491,GO:0016725,GO:0016726,GO:0016787,GO:0016801,GO:0016803,GO:0016822,GO:0016823,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 1.2.1.91,3.3.2.12 1.633e-254 805.0
HKD1_k127_1003241_30 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002633 430.0
HKD1_k127_1003241_31 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 428.0
HKD1_k127_1003241_32 asparaginase K13051 - 3.4.19.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 431.0
HKD1_k127_1003241_33 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007824 380.0
HKD1_k127_1003241_34 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 - 2.7.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 383.0
HKD1_k127_1003241_35 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 357.0
HKD1_k127_1003241_36 enoyl-CoA hydratase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003803 349.0
HKD1_k127_1003241_37 Cation efflux family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 357.0
HKD1_k127_1003241_38 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007237 375.0
HKD1_k127_1003241_39 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K15546 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 347.0
HKD1_k127_1003241_4 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 2.542e-230 724.0
HKD1_k127_1003241_40 Trypsin-like peptidase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 354.0
HKD1_k127_1003241_41 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 337.0
HKD1_k127_1003241_42 TonB-dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006253 350.0
HKD1_k127_1003241_43 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 323.0
HKD1_k127_1003241_44 Threonine dehydratase K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008867 308.0
HKD1_k127_1003241_45 Transport and Golgi organisation 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 307.0
HKD1_k127_1003241_46 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002071 307.0
HKD1_k127_1003241_47 Phenylacetic acid catabolic protein K02611 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005136 304.0
HKD1_k127_1003241_48 Protein of unknown function (DUF1348) K09958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 288.0
HKD1_k127_1003241_49 Phenazine biosynthesis-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 296.0
HKD1_k127_1003241_5 Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate K07516 - 1.1.1.35 5.441e-230 732.0
HKD1_k127_1003241_50 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 293.0
HKD1_k127_1003241_51 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 K02613 GO:0000166,GO:0003674,GO:0005488,GO:0006082,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0019439,GO:0019748,GO:0019752,GO:0032787,GO:0036094,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051537,GO:0051540,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097159,GO:0098754,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 296.0
HKD1_k127_1003241_52 Glutathione S-transferase, C-terminal domain K00799,K11209 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009268 287.0
HKD1_k127_1003241_53 Sugar (and other) transporter K08195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006886 294.0
HKD1_k127_1003241_54 Major Facilitator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001591 284.0
HKD1_k127_1003241_55 Belongs to the WrbA family K03809 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000183 285.0
HKD1_k127_1003241_56 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003162 266.0
HKD1_k127_1003241_57 HNH endonuclease K07454 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007233 273.0
HKD1_k127_1003241_58 Pfam:Pyridox_oxidase K07006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008207 247.0
HKD1_k127_1003241_59 Putative 2OG-Fe(II) oxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004782 261.0
HKD1_k127_1003241_6 TonB dependent receptor - - - 1.358e-228 731.0
HKD1_k127_1003241_60 COG3327 Phenylacetic acid-responsive transcriptional repressor K02616 - - 0.00000000000000000000000000000000000000000000000000000000000000000001214 244.0
HKD1_k127_1003241_61 Transcriptional regulator K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000001539 244.0
HKD1_k127_1003241_62 Protein of unknown function (DUF938) - - - 0.00000000000000000000000000000000000000000000000000000000000000569 222.0
HKD1_k127_1003241_63 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000258 221.0
HKD1_k127_1003241_64 Glutathione S-transferase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000001086 226.0
HKD1_k127_1003241_65 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000002499 215.0
HKD1_k127_1003241_66 Protein of unknown function DUF126 K09128 - - 0.00000000000000000000000000000000000000000000000000000000004202 221.0
HKD1_k127_1003241_67 helix_turn_helix isocitrate lyase regulation K02624 - - 0.00000000000000000000000000000000000000000000000000000004846 205.0
HKD1_k127_1003241_68 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000006793 194.0
HKD1_k127_1003241_69 translation initiation factor activity K06996 - - 0.000000000000000000000000000000000000000000000000001445 202.0
HKD1_k127_1003241_7 Belongs to the malate synthase family K01638 - 2.3.3.9 1.02e-219 694.0
HKD1_k127_1003241_70 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000253 194.0
HKD1_k127_1003241_71 Cysteine-rich secretory protein family - - - 0.0000000000000000000000000000000000000000000002998 179.0
HKD1_k127_1003241_72 Type II secretory pathway component ExeA K02450,K12283 - - 0.00000000000000000000000000000000000000000005648 175.0
HKD1_k127_1003241_73 phenylacetate-CoA oxygenase, PaaJ subunit K02612 - - 0.0000000000000000000000000000000000000000008296 171.0
HKD1_k127_1003241_74 Phenylacetic acid degradation protein K02614 GO:0003674,GO:0003824,GO:0016289,GO:0016787,GO:0016788,GO:0016790 - 0.00000000000000000000000000000000000000006287 160.0
HKD1_k127_1003241_75 Crp-like helix-turn-helix domain K21563 - - 0.00000000000000000000000000000000000000008421 160.0
HKD1_k127_1003241_76 Putative heavy-metal-binding - - - 0.0000000000000000000000000000000000000008828 167.0
HKD1_k127_1003241_77 With PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA K02610 - - 0.000000000000000000000000000000000000001227 155.0
HKD1_k127_1003241_79 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000009883 147.0
HKD1_k127_1003241_8 Catalyzes the reversible formation of glyoxylate and succinate from isocitrate K01637 - 4.1.3.1 3.321e-211 665.0
HKD1_k127_1003241_80 Histidine kinase K08082 - 2.7.13.3 0.0000000000000000000000000000000001558 147.0
HKD1_k127_1003241_81 Phospholipid methyltransferase - - - 0.000000000000000000000000000000002043 134.0
HKD1_k127_1003241_82 COG0575 CDP-diglyceride synthetase - - - 0.000000000000000000000000001072 118.0
HKD1_k127_1003241_83 ThiS family K03636 - - 0.00000000000000000000000003692 120.0
HKD1_k127_1003241_84 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004721,GO:0005488,GO:0005524,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009987,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050790,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 0.0000000000000000000000001736 113.0
HKD1_k127_1003241_85 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000002671 107.0
HKD1_k127_1003241_86 positive regulation of type IV pilus biogenesis K07343 - - 0.0000000000000000000000306 104.0
HKD1_k127_1003241_87 HNH endonuclease - - - 0.0000000000000000000003349 113.0
HKD1_k127_1003241_89 - - - - 0.00000000000000002414 93.0
HKD1_k127_1003241_9 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 1.14e-207 655.0
HKD1_k127_1003241_90 - - - - 0.000000000000000191 86.0
HKD1_k127_1003241_91 Acetyltransferase (GNAT) domain K02348 - - 0.00000000000001495 87.0
HKD1_k127_1029221_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0 1050.0
HKD1_k127_1029221_1 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 4.6e-322 998.0
HKD1_k127_1029221_10 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 609.0
HKD1_k127_1029221_11 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 539.0
HKD1_k127_1029221_12 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 529.0
HKD1_k127_1029221_13 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 537.0
HKD1_k127_1029221_14 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007226 511.0
HKD1_k127_1029221_15 Natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 497.0
HKD1_k127_1029221_16 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008521 512.0
HKD1_k127_1029221_17 Phosphate transporter family K03306 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008832 479.0
HKD1_k127_1029221_18 Glycosyltransferase family 9 (heptosyltransferase) K02849 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 389.0
HKD1_k127_1029221_19 Major facilitator superfamily K08151 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 374.0
HKD1_k127_1029221_2 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 1.653e-320 999.0
HKD1_k127_1029221_20 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001858 370.0
HKD1_k127_1029221_21 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000501 369.0
HKD1_k127_1029221_22 Transferase K02527 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 347.0
HKD1_k127_1029221_23 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008858 334.0
HKD1_k127_1029221_24 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 329.0
HKD1_k127_1029221_25 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 319.0
HKD1_k127_1029221_26 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006398 319.0
HKD1_k127_1029221_27 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 312.0
HKD1_k127_1029221_28 Protein of unknown function DUF47 K07220 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 301.0
HKD1_k127_1029221_29 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001289 270.0
HKD1_k127_1029221_3 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 1.965e-285 882.0
HKD1_k127_1029221_30 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000007897 253.0
HKD1_k127_1029221_31 type I secretion outer membrane protein, TolC K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000001187 250.0
HKD1_k127_1029221_32 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0033890,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000001201 243.0
HKD1_k127_1029221_33 Glutathione S-transferase, C-terminal domain K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000008327 236.0
HKD1_k127_1029221_34 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840 3.1.4.53 0.00000000000000000000000000000000000000000000000000000000003276 216.0
HKD1_k127_1029221_35 Nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ K09767 - - 0.0000000000000000000000000000000000000000000000000000000002973 209.0
HKD1_k127_1029221_36 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000008342 192.0
HKD1_k127_1029221_37 RIO1 family K11211 - 2.7.1.166 0.0000000000000000000000000000000000000000000000000001713 197.0
HKD1_k127_1029221_38 PFAM peptidase S16 lon domain protein K07157 - - 0.000000000000000000000000000000000000000000002601 175.0
HKD1_k127_1029221_39 7TMR-DISM extracellular 2 - - - 0.0000000000000000000000000000000000000000005576 179.0
HKD1_k127_1029221_4 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 2.086e-276 867.0
HKD1_k127_1029221_40 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000006109 151.0
HKD1_k127_1029221_41 PFAM glycosyl transferase family 9 - - - 0.000000000000000000000000000000000002109 151.0
HKD1_k127_1029221_42 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000004394 134.0
HKD1_k127_1029221_43 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000001252 115.0
HKD1_k127_1029221_44 - - - - 0.000000000000000000000004237 113.0
HKD1_k127_1029221_45 PQQ-like domain K05889 - 1.1.2.6 0.0000000000000000000002765 97.0
HKD1_k127_1029221_46 protein conserved in bacteria - - - 0.000000000000000001088 100.0
HKD1_k127_1029221_47 - - - - 0.0000000023 65.0
HKD1_k127_1029221_48 Acts as a magnesium transporter K06213 - - 0.00000001183 61.0
HKD1_k127_1029221_5 AAA domain - - - 8.859e-249 791.0
HKD1_k127_1029221_6 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 1.293e-235 760.0
HKD1_k127_1029221_7 PQQ-like domain K17760 - 1.1.9.1 7.03e-229 736.0
HKD1_k127_1029221_8 protease with the C-terminal PDZ domain - - - 2.367e-204 678.0
HKD1_k127_1029221_9 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 1.148e-201 636.0
HKD1_k127_1062493_0 Protein of unknown function, DUF255 K06888 - - 5.408e-239 762.0
HKD1_k127_1062493_1 Pro-apoptotic serine protease nma111. Source PGD - - - 6.204e-238 769.0
HKD1_k127_1062493_10 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000976 428.0
HKD1_k127_1062493_11 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 351.0
HKD1_k127_1062493_12 Belongs to the SUA5 family K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 346.0
HKD1_k127_1062493_13 PFAM short-chain dehydrogenase reductase SDR K00023,K00059 - 1.1.1.100,1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 335.0
HKD1_k127_1062493_14 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009447 332.0
HKD1_k127_1062493_15 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000299 336.0
HKD1_k127_1062493_16 diguanylate cyclase K13590,K21019 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 336.0
HKD1_k127_1062493_17 Phosphotransferase K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004642 314.0
HKD1_k127_1062493_18 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005827 278.0
HKD1_k127_1062493_19 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000001056 264.0
HKD1_k127_1062493_2 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 3.818e-233 729.0
HKD1_k127_1062493_20 Nucleotidyl transferase K00966,K00992 GO:0000166,GO:0000270,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006040,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0019103,GO:0019752,GO:0030203,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044281,GO:0046872,GO:0070569,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.7.13,2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000000000000912 249.0
HKD1_k127_1062493_21 PFAM ApaG domain protein K06195 - - 0.000000000000000000000000000000000000000000000000000224 188.0
HKD1_k127_1062493_22 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.00000000000000000000000000000000000000000003993 183.0
HKD1_k127_1062493_23 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000000000341 162.0
HKD1_k127_1062493_24 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.000000000000000000000000000000000000000002116 164.0
HKD1_k127_1062493_25 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000000000000000000003223 139.0
HKD1_k127_1062493_26 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.000000000000000000000000000000004056 131.0
HKD1_k127_1062493_27 Universal stress protein K06149 - - 0.0000000000000000000000000001964 119.0
HKD1_k127_1062493_28 HaD-superfamily hydrolase, subfamily ia, variant 3 K07025,K20866 - 3.1.3.10 0.000000000001083 77.0
HKD1_k127_1062493_29 membrane - - - 0.00000000522 61.0
HKD1_k127_1062493_3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004768 597.0
HKD1_k127_1062493_4 Glycine cleavage system P-protein K00282 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 582.0
HKD1_k127_1062493_5 Transport of potassium into the cell K03549 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 557.0
HKD1_k127_1062493_6 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009801 495.0
HKD1_k127_1062493_7 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 447.0
HKD1_k127_1062493_8 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 424.0
HKD1_k127_1062493_9 SAM-dependent K06969 - 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 424.0
HKD1_k127_1122881_0 alpha-L-rhamnosidase - - - 0.0 1324.0
HKD1_k127_1122881_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1215.0
HKD1_k127_1122881_10 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 349.0
HKD1_k127_1122881_11 electron transfer activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008447 347.0
HKD1_k127_1122881_12 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006947 270.0
HKD1_k127_1122881_13 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000001613 265.0
HKD1_k127_1122881_14 Protein of unknown function (DUF3237) - - - 0.0000000000000000000000000000000000000000000000001592 182.0
HKD1_k127_1122881_15 Signal peptidase (SPase) II K03101 - 3.4.23.36 0.000000000000000000000000000000000000000005698 177.0
HKD1_k127_1122881_16 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000000000000000003482 136.0
HKD1_k127_1122881_17 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000000009015 131.0
HKD1_k127_1122881_18 belongs to the Fur family K09826 - - 0.0000000000000000000000001327 117.0
HKD1_k127_1122881_19 rRNA binding K02968 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000002462 95.0
HKD1_k127_1122881_2 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 1.057e-261 821.0
HKD1_k127_1122881_20 TfoX C-terminal domain K07343 - - 0.0000000000006958 75.0
HKD1_k127_1122881_21 Pfam Hemerythrin HHE cation binding domain - - - 0.0000002589 60.0
HKD1_k127_1122881_22 TIGRFAM type IV pilus modification protein PilV K02671 - - 0.0000009415 57.0
HKD1_k127_1122881_23 COG4970 Tfp pilus assembly protein FimT K08084 - - 0.000007447 57.0
HKD1_k127_1122881_24 Type IV Pilus-assembly protein W K02672 - - 0.00003397 56.0
HKD1_k127_1122881_25 - - - - 0.0001465 48.0
HKD1_k127_1122881_3 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 9.87e-222 697.0
HKD1_k127_1122881_4 FMN-dependent alpha-hydroxy acid dehydrogenase K00101 - 1.1.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 516.0
HKD1_k127_1122881_5 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008198 449.0
HKD1_k127_1122881_6 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002414 445.0
HKD1_k127_1122881_7 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 373.0
HKD1_k127_1122881_8 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 359.0
HKD1_k127_1122881_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 360.0
HKD1_k127_116576_0 OPT oligopeptide transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 333.0
HKD1_k127_116576_1 Protein of unknown function (DUF1177) - - - 0.00000001835 55.0
HKD1_k127_1231216_0 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000001117 233.0
HKD1_k127_1231216_1 dolichyl monophosphate biosynthetic process K00981,K18678 - 2.7.1.182,2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000003197 240.0
HKD1_k127_1231216_2 S-adenosylmethionine diacylglycerol 3-amino-3-carboxypropyl transferase K13622 - - 0.000000000000000000000000000000000000000000000000000005232 196.0
HKD1_k127_1231216_3 Psort location Cytoplasmic, score 8.96 - - - 0.0000000000000000000000001379 119.0
HKD1_k127_1231216_4 UbiA prenyltransferase family K03179 - 2.5.1.39 0.000000000000000000001307 106.0
HKD1_k127_1231216_5 - - - - 0.000002243 57.0
HKD1_k127_128668_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1679.0
HKD1_k127_128668_1 WD40-like Beta Propeller Repeat - - - 0.0 1216.0
HKD1_k127_128668_10 Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process K05797 - 1.17.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 545.0
HKD1_k127_128668_11 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00499,K16319 - 1.14.12.1,1.14.15.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009754 539.0
HKD1_k127_128668_12 MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 505.0
HKD1_k127_128668_13 OPT oligopeptide transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 504.0
HKD1_k127_128668_14 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 441.0
HKD1_k127_128668_15 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 449.0
HKD1_k127_128668_16 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 422.0
HKD1_k127_128668_17 Acyl CoA acetate 3-ketoacid CoA transferase beta subunit K01040 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 416.0
HKD1_k127_128668_18 heterodisulfide reductase K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 432.0
HKD1_k127_128668_19 Protein of unknown function (DUF1298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008681 409.0
HKD1_k127_128668_2 Prolyl oligopeptidase family - - - 6.435e-297 925.0
HKD1_k127_128668_20 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 390.0
HKD1_k127_128668_21 PFAM Uroporphyrinogen decarboxylase (URO-D) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 382.0
HKD1_k127_128668_22 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 413.0
HKD1_k127_128668_23 PFAM Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 376.0
HKD1_k127_128668_24 Patatin-like phospholipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006502 364.0
HKD1_k127_128668_25 Transcriptional regulator K02624 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 335.0
HKD1_k127_128668_26 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008131 332.0
HKD1_k127_128668_27 Belongs to the heme-copper respiratory oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 316.0
HKD1_k127_128668_28 PFAM Methylene-tetrahydrofolate reductase C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008353 297.0
HKD1_k127_128668_29 Amidohydrolase K07045,K14333,K20941 - 4.1.1.103,4.1.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005505 290.0
HKD1_k127_128668_3 Aldehyde dehydrogenase family K00294 - 1.2.1.88 6.464e-255 794.0
HKD1_k127_128668_30 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000001825 230.0
HKD1_k127_128668_31 Belongs to the GST superfamily K11209 - - 0.0000000000000000000000000000000000000000000000000000009585 195.0
HKD1_k127_128668_32 - - - - 0.0000000000000000000000000000000000000000001873 171.0
HKD1_k127_128668_33 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.000000000000000000000000000000000000000001319 175.0
HKD1_k127_128668_34 Pfam Hemerythrin HHE - - - 0.00000000000000000000000000000000000001937 149.0
HKD1_k127_128668_35 - - - - 0.0000000000000000000000000000000000008588 157.0
HKD1_k127_128668_36 - - - - 0.00000000000000000000000000000000002467 146.0
HKD1_k127_128668_37 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000004705 144.0
HKD1_k127_128668_38 - - - - 0.000000000000000000000000004075 116.0
HKD1_k127_128668_39 Uncharacterized conserved protein (DUF2249) - - - 0.00000000000000001178 86.0
HKD1_k127_128668_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 1.366e-239 751.0
HKD1_k127_128668_40 Poly(hydroxyalcanoate) granule associated protein - - - 0.0000000000000004923 86.0
HKD1_k127_128668_41 overlaps another CDS with the same product name - - - 0.000000000000122 77.0
HKD1_k127_128668_42 Aldehyde dehydrogenase family K00154,K22445 - 1.2.1.68,1.2.99.10 0.0000000000004929 73.0
HKD1_k127_128668_5 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 7.328e-238 745.0
HKD1_k127_128668_6 dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes - - - 1.827e-233 742.0
HKD1_k127_128668_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 9.378e-214 672.0
HKD1_k127_128668_8 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 1.596e-204 663.0
HKD1_k127_128668_9 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 556.0
HKD1_k127_1288171_0 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 480.0
HKD1_k127_1288171_1 Protein of unknown function (DUF2878) - - - 0.00000000000000000000000000000000009356 147.0
HKD1_k127_1288171_2 3-oxo-5-alpha-steroid 4-dehydrogenase - - - 0.00000000000000000000001114 104.0
HKD1_k127_1288171_3 Sigma-70, region 4 K03088 - - 0.0000000000004212 74.0
HKD1_k127_1308383_0 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001805 447.0
HKD1_k127_1308383_1 Major facilitator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000308 416.0
HKD1_k127_1308383_2 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 371.0
HKD1_k127_1308383_3 Major facilitator superfamily K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 370.0
HKD1_k127_1308383_4 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004107 344.0
HKD1_k127_1308383_5 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002512 273.0
HKD1_k127_1330309_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007194 383.0
HKD1_k127_1330309_1 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000002915 182.0
HKD1_k127_1330309_2 Putative undecaprenyl diphosphate synthase K00806 - 2.5.1.31 0.00000000000000000000000004206 109.0
HKD1_k127_1388747_0 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008309 596.0
HKD1_k127_1388747_1 Belongs to the type-B carboxylesterase lipase family K03929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 458.0
HKD1_k127_1388747_2 Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 353.0
HKD1_k127_1388747_3 Major Facilitator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001694 278.0
HKD1_k127_1388747_4 - - - - 0.00000000000000000000002042 104.0
HKD1_k127_1388747_5 Gluconate 2-dehydrogenase subunit 3 - - - 0.000000000000000000002071 108.0
HKD1_k127_1388747_6 Major Facilitator - - - 0.00000000000000015 82.0
HKD1_k127_1388747_7 Electron transfer flavoprotein K03522 - - 0.00000000000002172 72.0
HKD1_k127_1388747_8 PFAM Xylose isomerase-like TIM barrel - - - 0.0000000000002036 81.0
HKD1_k127_1476107_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1337.0
HKD1_k127_1476107_1 PFAM peptidase S10 serine carboxypeptidase - - - 5.601e-211 667.0
HKD1_k127_1476107_10 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000002545 128.0
HKD1_k127_1476107_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 3.891e-198 626.0
HKD1_k127_1476107_3 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 465.0
HKD1_k127_1476107_4 PFAM PhoH family protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 406.0
HKD1_k127_1476107_5 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009137 372.0
HKD1_k127_1476107_6 PFAM CBS domain K06189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 306.0
HKD1_k127_1476107_7 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000000001234 196.0
HKD1_k127_1476107_8 COG3555 Aspartyl asparaginyl beta-hydroxylase and related dioxygenases K12979 - - 0.0000000000000000000000000000000000000000001902 161.0
HKD1_k127_1476107_9 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000004745 127.0
HKD1_k127_157973_0 Peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006983 277.0
HKD1_k127_157973_1 Belongs to the SUA5 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003316 267.0
HKD1_k127_157973_2 PFAM Aminoacyl-tRNA synthetase, class Ib K01867 - 6.1.1.2 0.000000000000008188 83.0
HKD1_k127_157973_3 Bacterial regulatory helix-turn-helix protein, lysR family K13634 - - 0.000000000009172 66.0
HKD1_k127_1845031_0 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 351.0
HKD1_k127_1845031_1 - - - - 0.0000000000000000000000000005915 130.0
HKD1_k127_1845031_2 oxygen carrier activity K07216 - - 0.00000000000000000000000006536 119.0
HKD1_k127_1878676_0 belongs to the aldehyde dehydrogenase family K00151 - 1.2.1.60 2.002e-268 833.0
HKD1_k127_1878676_1 PQQ-like domain K17760 - 1.1.9.1 1.583e-236 755.0
HKD1_k127_1878676_10 CoA-transferase family III K01796 - 5.1.99.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004419 391.0
HKD1_k127_1878676_11 Protein of unknown function (DUF1282) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005748 387.0
HKD1_k127_1878676_12 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007869 342.0
HKD1_k127_1878676_13 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 307.0
HKD1_k127_1878676_14 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004857 274.0
HKD1_k127_1878676_16 Fumarylacetoacetate (FAA) hydrolase family K05921 - 4.1.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000002884 261.0
HKD1_k127_1878676_17 Maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000002292 263.0
HKD1_k127_1878676_18 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004389 248.0
HKD1_k127_1878676_19 5-carboxymethyl-2-hydroxymuconate isomerase K01826 - 5.3.3.10 0.0000000000000000000000000000000000000000000002076 180.0
HKD1_k127_1878676_2 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 6.357e-206 653.0
HKD1_k127_1878676_21 homoprotocatechuate degradation operon regulator, HpaR - - - 0.000000000000000000000000000000000000000003235 161.0
HKD1_k127_1878676_22 amp-dependent synthetase and ligase - - - 0.00000000000000000000000000006312 119.0
HKD1_k127_1878676_23 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000002029 106.0
HKD1_k127_1878676_3 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007491 517.0
HKD1_k127_1878676_4 N-methylhydantoinase A acetone carboxylase, beta subunit K01473 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 522.0
HKD1_k127_1878676_5 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006172 481.0
HKD1_k127_1878676_6 Fumarylacetoacetate (FAA) hydrolase family K02509,K18364 - 4.2.1.132,4.2.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007839 424.0
HKD1_k127_1878676_7 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007649 403.0
HKD1_k127_1878676_8 TIGRFAM 4-hydroxyphenylacetate degradation bifunctional isomerase decarboxylase,HpaG2 subunit K05921 - 4.1.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000364 387.0
HKD1_k127_1878676_9 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003633 398.0
HKD1_k127_196498_0 Cellulose synthase K00694 - 2.4.1.12 4.447e-252 801.0
HKD1_k127_196498_1 cellulose synthase K20541 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 592.0
HKD1_k127_196498_2 Glycosyl hydrolases family 8 K01179,K20542 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 331.0
HKD1_k127_196498_3 Cellulose synthase operon protein C C-terminus (BCSC_C) K20543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002698 270.0
HKD1_k127_2005922_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 0.0 1088.0
HKD1_k127_2005922_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 6.112e-224 716.0
HKD1_k127_2005922_10 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008125 386.0
HKD1_k127_2005922_11 Long-chain fatty acid transport protein K06076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007877 377.0
HKD1_k127_2005922_12 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 336.0
HKD1_k127_2005922_13 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007667 317.0
HKD1_k127_2005922_14 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 301.0
HKD1_k127_2005922_15 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00824 - 2.6.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000001173 287.0
HKD1_k127_2005922_16 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000002792 260.0
HKD1_k127_2005922_17 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000000000003235 256.0
HKD1_k127_2005922_18 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000002109 241.0
HKD1_k127_2005922_19 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000000151 240.0
HKD1_k127_2005922_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 2.139e-217 684.0
HKD1_k127_2005922_20 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000000000000000000146 241.0
HKD1_k127_2005922_21 COG2951 Membrane-bound lytic murein transglycosylase B K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000005212 245.0
HKD1_k127_2005922_22 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.0000000000000000000000000000000000000000000000000000000000000008968 229.0
HKD1_k127_2005922_23 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000001397 220.0
HKD1_k127_2005922_24 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000000000000000000000000000000000000000000000000000000002555 231.0
HKD1_k127_2005922_25 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000008434 216.0
HKD1_k127_2005922_26 Putative member of DMT superfamily (DUF486) K09922 - - 0.000000000000000000000000000000000000000000000000000004858 193.0
HKD1_k127_2005922_27 - - - - 0.000000000000000000000000000000000000001486 160.0
HKD1_k127_2005922_28 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000006077 166.0
HKD1_k127_2005922_29 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000007174 140.0
HKD1_k127_2005922_3 TIGRFAM Cell shape determining protein MreB Mrl K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 561.0
HKD1_k127_2005922_30 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000001665 141.0
HKD1_k127_2005922_31 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564 - 0.00000000000000000000000073 121.0
HKD1_k127_2005922_32 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000007406 101.0
HKD1_k127_2005922_33 Domain of unknown function (DUF4440) - - - 0.00000000000000000001615 91.0
HKD1_k127_2005922_34 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 - - 0.000000000000001701 86.0
HKD1_k127_2005922_36 Hemolysin-type calcium-binding repeat 2 copies family protein - - - 0.0000003245 63.0
HKD1_k127_2005922_4 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007169 565.0
HKD1_k127_2005922_5 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003119 544.0
HKD1_k127_2005922_6 Domain of unknown function (DUF4147) K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 520.0
HKD1_k127_2005922_7 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 483.0
HKD1_k127_2005922_8 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005261 471.0
HKD1_k127_2005922_9 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 409.0
HKD1_k127_2034262_0 AcrB/AcrD/AcrF family K07787 - - 0.0 1609.0
HKD1_k127_2034262_1 NADH:flavin oxidoreductase / NADH oxidase family K09461 - 1.14.13.40 0.0 1266.0
HKD1_k127_2034262_10 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 398.0
HKD1_k127_2034262_11 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003481 360.0
HKD1_k127_2034262_12 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 364.0
HKD1_k127_2034262_13 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 356.0
HKD1_k127_2034262_14 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 344.0
HKD1_k127_2034262_15 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000451 310.0
HKD1_k127_2034262_16 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005169 300.0
HKD1_k127_2034262_17 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001486 274.0
HKD1_k127_2034262_18 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000002339 250.0
HKD1_k127_2034262_19 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000000000113 187.0
HKD1_k127_2034262_2 TIGRFAM acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 1.711e-219 688.0
HKD1_k127_2034262_20 Glutathione S-transferase, C-terminal domain K11209 - - 0.000000000000000000000000000000000000000000000000004077 192.0
HKD1_k127_2034262_21 Glutathione S-transferase, C-terminal domain K11209 - - 0.0000000000000000000000000000000000000000000000003707 185.0
HKD1_k127_2034262_22 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000006559 181.0
HKD1_k127_2034262_23 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.0000000000000000000000000000000000000000000003583 173.0
HKD1_k127_2034262_24 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000000000009787 172.0
HKD1_k127_2034262_25 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - 0.0000000000000000000000000000000000000000004452 165.0
HKD1_k127_2034262_26 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000001208 137.0
HKD1_k127_2034262_27 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000129 116.0
HKD1_k127_2034262_28 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters K03557 GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000001027 94.0
HKD1_k127_2034262_29 copper export protein K07245,K14166 - - 0.0000000000000000001146 100.0
HKD1_k127_2034262_3 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 2.254e-212 672.0
HKD1_k127_2034262_30 Copper binding periplasmic protein CusF K07810 - - 0.000000000000000000989 89.0
HKD1_k127_2034262_31 protein, homolog of Cu resistance protein CopC K07156 - - 0.0000000009483 71.0
HKD1_k127_2034262_32 MJ0042 family finger-like - - - 0.00000001839 66.0
HKD1_k127_2034262_4 NADH oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 612.0
HKD1_k127_2034262_5 Belongs to the GARS family K01945,K13713 GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 529.0
HKD1_k127_2034262_6 Belongs to the thiolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 511.0
HKD1_k127_2034262_7 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 494.0
HKD1_k127_2034262_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 487.0
HKD1_k127_2034262_9 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase component beta subunit K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 443.0
HKD1_k127_2046032_0 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008183 432.0
HKD1_k127_2057738_0 Flavin containing amine oxidoreductase - - - 4.796e-247 778.0
HKD1_k127_2057738_1 Peptidase family M3 K01414 GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 1.402e-212 681.0
HKD1_k127_2057738_10 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000001371 187.0
HKD1_k127_2057738_11 MlaD protein K02067,K06192 - - 0.00000000000000000000000000000000008918 146.0
HKD1_k127_2057738_12 HxlR-like helix-turn-helix - - - 0.0000000000000000000000000000000008614 137.0
HKD1_k127_2057738_13 Iron-binding zinc finger CDGSH type - - - 0.000000000000000000000000000000003275 129.0
HKD1_k127_2057738_14 - - - - 0.0000000000000000000103 106.0
HKD1_k127_2057738_15 transport system auxiliary component K18480 - - 0.00000000000000009776 94.0
HKD1_k127_2057738_16 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.00000000004607 67.0
HKD1_k127_2057738_2 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 552.0
HKD1_k127_2057738_3 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008386 428.0
HKD1_k127_2057738_4 exodeoxyribonuclease III K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 361.0
HKD1_k127_2057738_5 ATPases associated with a variety of cellular activities K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005077 293.0
HKD1_k127_2057738_6 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001208 276.0
HKD1_k127_2057738_7 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003001 272.0
HKD1_k127_2057738_8 diguanylate cyclase K13590 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000007883 235.0
HKD1_k127_2057738_9 D-alanyl-D-alanine carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000007658 227.0
HKD1_k127_2059376_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003712 313.0
HKD1_k127_2059376_1 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000001425 229.0
HKD1_k127_2059376_2 Cytochrome P450 - - - 0.00000000000000000000000000000000000000002843 156.0
HKD1_k127_2139863_0 Lon protease (S16) C-terminal proteolytic domain K01338 - 3.4.21.53 7.86e-322 1009.0
HKD1_k127_2139863_1 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 1.275e-232 740.0
HKD1_k127_2139863_10 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002792 256.0
HKD1_k127_2139863_11 Cytochrome B561 K12262 - - 0.00000000000000000000000000000000000000000000000000000000000000000001577 238.0
HKD1_k127_2139863_12 HDOD domain K03088 - - 0.00000000000000000000000000000000000000000000000000000008724 203.0
HKD1_k127_2139863_13 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000000000000486 171.0
HKD1_k127_2139863_14 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000005164 168.0
HKD1_k127_2139863_15 Universal stress protein - - - 0.000000000000000000000000000000000000004011 151.0
HKD1_k127_2139863_16 - - - - 0.00000000000000000000000002582 114.0
HKD1_k127_2139863_17 Hsp20/alpha crystallin family - - - 0.000000000000000000000002543 107.0
HKD1_k127_2139863_18 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000003781 108.0
HKD1_k127_2139863_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009603 523.0
HKD1_k127_2139863_20 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.000000000008344 67.0
HKD1_k127_2139863_21 Bacterial protein of unknown function (DUF883) - - - 0.0000000004926 64.0
HKD1_k127_2139863_3 amidohydrolase K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008963 494.0
HKD1_k127_2139863_4 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 422.0
HKD1_k127_2139863_5 Uncharacterised protein family UPF0052 K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005557 373.0
HKD1_k127_2139863_6 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 350.0
HKD1_k127_2139863_7 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003744 340.0
HKD1_k127_2139863_8 RDD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008688 350.0
HKD1_k127_2139863_9 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000891 302.0
HKD1_k127_2142616_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K18361 - 1.17.5.1,3.1.2.25 0.0 1290.0
HKD1_k127_2142616_1 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K00087,K03520,K04108 - 1.17.1.4,1.2.5.3,1.3.7.9 0.0 1262.0
HKD1_k127_2142616_10 benzoyl-CoA reductase K04113 - 1.3.7.8 9.671e-236 747.0
HKD1_k127_2142616_11 TIGRFAM cytochrome c-type biogenesis protein CcmF K02198 - - 8.143e-220 700.0
HKD1_k127_2142616_12 Benzoyl-CoA reductase subunit K04114 - 1.3.7.8 1.088e-214 674.0
HKD1_k127_2142616_13 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 2.123e-212 689.0
HKD1_k127_2142616_14 benzoate-CoA ligase K04105 - 6.2.1.25,6.2.1.27 1.57e-211 682.0
HKD1_k127_2142616_15 PFAM Uncharacterised protein family UPF0027 K14415 - 6.5.1.3 2.538e-203 642.0
HKD1_k127_2142616_16 PFAM monooxygenase FAD-binding K05712 - 1.14.13.127 1.303e-195 625.0
HKD1_k127_2142616_17 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 620.0
HKD1_k127_2142616_18 COG1960 Acyl-CoA dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002838 600.0
HKD1_k127_2142616_19 DNA polymerase X family K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 604.0
HKD1_k127_2142616_2 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K00087,K03520,K04108 - 1.17.1.4,1.2.5.3,1.3.7.9 0.0 1167.0
HKD1_k127_2142616_20 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 588.0
HKD1_k127_2142616_21 CoA-transferase family III K07749 - 2.8.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006865 589.0
HKD1_k127_2142616_22 Enoyl-CoA hydratase/isomerase K07539 - 3.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009806 565.0
HKD1_k127_2142616_23 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 550.0
HKD1_k127_2142616_24 Bacterial capsule synthesis protein PGA_cap - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 502.0
HKD1_k127_2142616_25 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 485.0
HKD1_k127_2142616_26 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 482.0
HKD1_k127_2142616_27 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 474.0
HKD1_k127_2142616_28 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 499.0
HKD1_k127_2142616_29 Uncharacterised MFS-type transporter YbfB K05548,K05819,K08195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 484.0
HKD1_k127_2142616_3 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1035.0
HKD1_k127_2142616_30 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07538 - 1.1.1.368 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 456.0
HKD1_k127_2142616_31 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 415.0
HKD1_k127_2142616_32 BadF/BadG/BcrA/BcrD ATPase family K04115 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 398.0
HKD1_k127_2142616_33 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009708 416.0
HKD1_k127_2142616_34 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 385.0
HKD1_k127_2142616_35 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K04109,K11178 - 1.17.1.4,1.3.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003275 348.0
HKD1_k127_2142616_36 4Fe-4S binding domain K18362 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 331.0
HKD1_k127_2142616_37 protein involved in response to NO K07234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 334.0
HKD1_k127_2142616_38 COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004612 326.0
HKD1_k127_2142616_39 Cytochrome C assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 305.0
HKD1_k127_2142616_4 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 1.036e-312 970.0
HKD1_k127_2142616_40 Short-chain dehydrogenase reductase sdr - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003307 303.0
HKD1_k127_2142616_41 Helix-hairpin-helix domain K04477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 300.0
HKD1_k127_2142616_42 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 297.0
HKD1_k127_2142616_43 KR domain K07535 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001668 288.0
HKD1_k127_2142616_44 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004258 289.0
HKD1_k127_2142616_45 FCD K11475 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001978 280.0
HKD1_k127_2142616_46 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000205 291.0
HKD1_k127_2142616_47 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004104 271.0
HKD1_k127_2142616_48 carboxymethylenebutenolidase activity K01061,K07100 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000001614 250.0
HKD1_k127_2142616_49 Major Facilitator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002148 256.0
HKD1_k127_2142616_5 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.28e-286 893.0
HKD1_k127_2142616_50 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001725 249.0
HKD1_k127_2142616_51 aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518,K04107 - 1.2.5.3,1.3.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000207 245.0
HKD1_k127_2142616_52 PFAM Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002632 241.0
HKD1_k127_2142616_53 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001055 231.0
HKD1_k127_2142616_54 GntR family - - - 0.000000000000000000000000000000000000000000000000000000000000000005606 233.0
HKD1_k127_2142616_55 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000002148 234.0
HKD1_k127_2142616_56 XdhC Rossmann domain K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000002304 230.0
HKD1_k127_2142616_57 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000002883 222.0
HKD1_k127_2142616_58 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000009918 219.0
HKD1_k127_2142616_59 DMSO reductase anchor subunit (DmsC) K18363 - - 0.0000000000000000000000000000000000000000000000000000000000001523 231.0
HKD1_k127_2142616_6 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 1.66e-286 893.0
HKD1_k127_2142616_60 PFAM Cold-shock protein, DNA-binding - - - 0.00000000000000000000000000000000000000000000000000000000001738 211.0
HKD1_k127_2142616_61 PFAM regulatory protein, MerR - - - 0.00000000000000000000000000000000000000000000000000000001937 199.0
HKD1_k127_2142616_62 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.00000000000000000000000000000000000000000000000000004357 200.0
HKD1_k127_2142616_63 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs - - - 0.0000000000000000000000000000000000000000000000000001017 194.0
HKD1_k127_2142616_64 B12 binding domain K01849,K20907 - 5.4.99.2,5.4.99.64 0.0000000000000000000000000000000000000000000000008976 177.0
HKD1_k127_2142616_65 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000000000003543 174.0
HKD1_k127_2142616_66 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000001109 173.0
HKD1_k127_2142616_67 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015886,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051181,GO:0051234,GO:0065003,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097159,GO:0098552,GO:0098567,GO:1901363,GO:1901564,GO:1901678 - 0.000000000000000000000000000000000000000000001194 172.0
HKD1_k127_2142616_68 Archease protein family (MTH1598/TM1083) - - - 0.00000000000000000000000000000000000000000001773 166.0
HKD1_k127_2142616_69 transcriptional regulator K03719 - - 0.00000000000000000000000000000000000000000001813 166.0
HKD1_k127_2142616_7 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 1.39e-271 859.0
HKD1_k127_2142616_70 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000299 162.0
HKD1_k127_2142616_71 TIGRFAM periplasmic protein K02199 - - 0.000000000000000000000000000000000000000000143 170.0
HKD1_k127_2142616_72 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000005807 167.0
HKD1_k127_2142616_73 Thioesterase - - - 0.000000000000000000000000000000000000001462 153.0
HKD1_k127_2142616_74 transcriptional regulator - - - 0.00000000000000000000000000000000000008253 147.0
HKD1_k127_2142616_75 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000001451 147.0
HKD1_k127_2142616_76 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.0000000000000000000000000000000000001853 143.0
HKD1_k127_2142616_77 Domain of unknown function DUF302 - - - 0.0000000000000000000000000000000000003723 148.0
HKD1_k127_2142616_78 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000001372 146.0
HKD1_k127_2142616_79 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000000000000000000000000000000001611 150.0
HKD1_k127_2142616_8 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly - - - 2.964e-256 800.0
HKD1_k127_2142616_80 - - - - 0.0000000000000000000000000000000000334 149.0
HKD1_k127_2142616_81 ferredoxin - - - 0.000000000000000000000000000000005533 131.0
HKD1_k127_2142616_82 RDD family - - - 0.0000000000000000000000000000001168 138.0
HKD1_k127_2142616_83 subunit of a heme lyase K02200 - - 0.0000000000000000000000000002584 119.0
HKD1_k127_2142616_84 acetyltransferase - - - 0.000000000000000000000000001407 118.0
HKD1_k127_2142616_85 Rubrerythrin - - - 0.000000000000000000006487 104.0
HKD1_k127_2142616_86 Methionine synthase K00549 - 2.1.1.14 0.000000000000000003822 86.0
HKD1_k127_2142616_87 Cytochrome c-type biogenesis protein K02200 - - 0.0000000000001357 81.0
HKD1_k127_2142616_89 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000001454 68.0
HKD1_k127_2142616_9 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 1.241e-237 747.0
HKD1_k127_2142616_91 - - - - 0.00003641 51.0
HKD1_k127_2146279_0 NAD(P)-binding Rossmann-like domain - - - 7.601e-266 833.0
HKD1_k127_2146279_1 Glycolate oxidase subunit GlcD K00104 - 1.1.3.15 2.727e-232 728.0
HKD1_k127_2146279_10 chain release factor K15034 - - 0.0000000000000000000000000005564 120.0
HKD1_k127_2146279_11 ketosteroid isomerase - - - 0.0000000000000000000000000007715 127.0
HKD1_k127_2146279_12 small protein containing a coiled-coil domain - - - 0.00000000000002105 76.0
HKD1_k127_2146279_13 COG1309 Transcriptional regulator - - - 0.0000000001056 71.0
HKD1_k127_2146279_14 TonB dependent receptor - - - 0.000000001665 59.0
HKD1_k127_2146279_2 glycolate oxidase iron-sulfur subunit K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 557.0
HKD1_k127_2146279_3 FAD binding domain K11472 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 441.0
HKD1_k127_2146279_4 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 422.0
HKD1_k127_2146279_5 Formate/nitrite transporter K02598,K21993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007716 341.0
HKD1_k127_2146279_6 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 313.0
HKD1_k127_2146279_7 Inositol monophosphatase family K01082 - 3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002073 287.0
HKD1_k127_2146279_8 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000001318 235.0
HKD1_k127_2146279_9 pfam php K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000000000000000009075 226.0
HKD1_k127_2149203_0 TonB dependent receptor - - - 0.0 1238.0
HKD1_k127_2149203_1 Dehydrogenase K17760 - 1.1.9.1 0.0 1200.0
HKD1_k127_2149203_10 Dienelactone hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009175 405.0
HKD1_k127_2149203_11 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000103 244.0
HKD1_k127_2149203_12 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase K07006 - - 0.00000000000000000000000000000000000000000000000003331 185.0
HKD1_k127_2149203_13 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000001513 196.0
HKD1_k127_2149203_14 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000000153 100.0
HKD1_k127_2149203_15 Periplasmic copper-binding protein (NosD) - - - 0.000000000000000005848 99.0
HKD1_k127_2149203_16 - - - - 0.000000003395 68.0
HKD1_k127_2149203_17 Elongation factor SelB, winged helix K03833 - - 0.0000000546 55.0
HKD1_k127_2149203_18 Beta-lactamase K18372 - - 0.00006045 46.0
HKD1_k127_2149203_2 (GMC) oxidoreductase K00108 - 1.1.99.1 4.063e-268 837.0
HKD1_k127_2149203_3 Belongs to the IlvD Edd family K01687 - 4.2.1.9 4.549e-264 848.0
HKD1_k127_2149203_4 FAD dependent oxidoreductase - - - 1.928e-241 753.0
HKD1_k127_2149203_5 Elongation factor SelB, winged helix K03833 - - 2.986e-213 691.0
HKD1_k127_2149203_6 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 550.0
HKD1_k127_2149203_7 AIR synthase related protein, C-terminal domain K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 503.0
HKD1_k127_2149203_8 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 452.0
HKD1_k127_2149203_9 Sugar (and other) transporter K08195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 450.0
HKD1_k127_2159703_0 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000005337 220.0
HKD1_k127_2159703_1 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000257 183.0
HKD1_k127_2159703_2 - - - - 0.000000000000000149 87.0
HKD1_k127_2232640_0 Uncharacterised protein family (UPF0182) K09118 - - 1.591e-219 712.0
HKD1_k127_2232640_1 Domain of unknown function (DUF4143) K07133 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000561 591.0
HKD1_k127_2232640_2 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000004355 179.0
HKD1_k127_2232640_3 membrane K08973 - - 0.000000000000000000000000000000000001464 143.0
HKD1_k127_2232640_4 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.0000000000000000000001571 111.0
HKD1_k127_2232640_5 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.000000000000000000002658 94.0
HKD1_k127_2232640_6 toxin-antitoxin pair type II binding - - - 0.00000002522 59.0
HKD1_k127_2265657_0 peptidyl-tyrosine modification K06139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 485.0
HKD1_k127_2265657_1 Predicted Permease Membrane Region K07085 - - 0.00000000000000000000000000006643 118.0
HKD1_k127_2265657_2 Pyrroloquinoline quinone biosynthesis protein D K06138 - - 0.000000000002485 71.0
HKD1_k127_2281481_0 Poly-beta-hydroxybutyrate polymerase K03821 - - 1.792e-282 880.0
HKD1_k127_2281481_1 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006583 599.0
HKD1_k127_2281481_10 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 350.0
HKD1_k127_2281481_11 Repeat of Unknown Function (DUF347) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 324.0
HKD1_k127_2281481_12 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 325.0
HKD1_k127_2281481_13 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 325.0
HKD1_k127_2281481_14 amino acid K16238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004484 306.0
HKD1_k127_2281481_15 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 297.0
HKD1_k127_2281481_16 beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001867 282.0
HKD1_k127_2281481_17 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008118 254.0
HKD1_k127_2281481_18 In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 K09020 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.1.110 0.000000000000000000000000000000000000000000000000000000000000000004632 233.0
HKD1_k127_2281481_19 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000006773 200.0
HKD1_k127_2281481_2 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 602.0
HKD1_k127_2281481_20 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000003078 164.0
HKD1_k127_2281481_21 transcriptional regulator, TetR family - - - 0.00000000000000000000000000000002552 138.0
HKD1_k127_2281481_23 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000005491 68.0
HKD1_k127_2281481_3 PFAM NADH flavin oxidoreductase NADH oxidase K10680 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 552.0
HKD1_k127_2281481_4 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 539.0
HKD1_k127_2281481_5 FAD linked oxidase domain protein K05797 - 1.17.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 486.0
HKD1_k127_2281481_6 of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 378.0
HKD1_k127_2281481_7 homoserine kinase type II (Protein kinase fold) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002063 360.0
HKD1_k127_2281481_8 Berberine and berberine like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 368.0
HKD1_k127_2281481_9 COG0685 5,10-methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 357.0
HKD1_k127_2297931_0 Phosphopantetheine attachment site K00666 - - 6.96e-246 790.0
HKD1_k127_2297931_1 TIGRFAM decaheme c-type cytochrome, OmcA MtrC family - - - 3.376e-216 692.0
HKD1_k127_2297931_2 aminotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004397 561.0
HKD1_k127_2297931_3 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004918 383.0
HKD1_k127_2297931_4 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 394.0
HKD1_k127_2297931_5 cytochrome C family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 321.0
HKD1_k127_2297931_6 metal cluster binding K03497 - - 0.000000000002551 73.0
HKD1_k127_2297931_7 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360 6.5.1.4 0.00000005937 54.0
HKD1_k127_2309349_0 Acetyl-coenzyme A synthetase N-terminus K01907 - 6.2.1.16 6.757e-319 988.0
HKD1_k127_2309349_1 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 1.846e-292 904.0
HKD1_k127_2309349_10 Aspartyl/Asparaginyl beta-hydroxylase - - - 3.561e-207 662.0
HKD1_k127_2309349_100 CpeT/CpcT family (DUF1001) - - - 0.0000000000004331 82.0
HKD1_k127_2309349_101 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000001001 66.0
HKD1_k127_2309349_11 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 2.324e-206 670.0
HKD1_k127_2309349_12 receptor - - - 1.288e-196 647.0
HKD1_k127_2309349_13 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 623.0
HKD1_k127_2309349_14 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 606.0
HKD1_k127_2309349_15 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008203 598.0
HKD1_k127_2309349_16 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) K01555 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 598.0
HKD1_k127_2309349_17 Belongs to the glycosyl hydrolase 57 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 585.0
HKD1_k127_2309349_18 histidine ammonia-lyase activity K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 576.0
HKD1_k127_2309349_19 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 556.0
HKD1_k127_2309349_2 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 6.452e-282 883.0
HKD1_k127_2309349_20 Cardiolipin synthase K06132 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 558.0
HKD1_k127_2309349_21 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 551.0
HKD1_k127_2309349_22 2-Nitropropane dioxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008535 536.0
HKD1_k127_2309349_23 GDP-mannose 4,6 dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 546.0
HKD1_k127_2309349_24 Belongs to the DegT DnrJ EryC1 family K02805 - 2.6.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 516.0
HKD1_k127_2309349_25 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 485.0
HKD1_k127_2309349_26 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 484.0
HKD1_k127_2309349_27 PQQ-like domain K05889 - 1.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 489.0
HKD1_k127_2309349_28 Peptidase U32 K08303 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 462.0
HKD1_k127_2309349_29 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 455.0
HKD1_k127_2309349_3 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 1.171e-275 872.0
HKD1_k127_2309349_30 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 443.0
HKD1_k127_2309349_31 imidazolonepropionase activity K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 449.0
HKD1_k127_2309349_32 Berberine and berberine like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003334 420.0
HKD1_k127_2309349_33 Pfam Glycosyl transferase family 2 K10012 - 2.4.2.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 429.0
HKD1_k127_2309349_34 Retinal pigment epithelial membrane protein K11159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 418.0
HKD1_k127_2309349_35 Sugar (and other) transporter K08195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007273 411.0
HKD1_k127_2309349_36 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008039 419.0
HKD1_k127_2309349_37 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 404.0
HKD1_k127_2309349_38 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 390.0
HKD1_k127_2309349_39 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004923 382.0
HKD1_k127_2309349_4 Ferrous iron transport protein B C terminus K04759 - - 4.862e-239 756.0
HKD1_k127_2309349_40 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008131 387.0
HKD1_k127_2309349_41 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 389.0
HKD1_k127_2309349_42 GDSL-like Lipase/Acylhydrolase K12686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 396.0
HKD1_k127_2309349_43 Sulfotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 389.0
HKD1_k127_2309349_44 SMART Peptidoglycan-binding Lysin subgroup K16291 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 379.0
HKD1_k127_2309349_45 Aspartyl/Asparaginyl beta-hydroxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003419 376.0
HKD1_k127_2309349_46 PFAM formyl transferase domain protein K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 374.0
HKD1_k127_2309349_47 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides K13014 GO:0005575,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0042221,GO:0050896 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003085 364.0
HKD1_k127_2309349_48 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 375.0
HKD1_k127_2309349_49 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 358.0
HKD1_k127_2309349_5 Homospermidine synthase K00808 - 2.5.1.44 1.498e-233 729.0
HKD1_k127_2309349_50 TIGRFAM 3-oxoacid CoA-transferase, A subunit K01028 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 351.0
HKD1_k127_2309349_51 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01029 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002249 355.0
HKD1_k127_2309349_52 Domain of unknown function(DUF2779) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 336.0
HKD1_k127_2309349_53 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008882 320.0
HKD1_k127_2309349_54 Dehydrogenase K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 323.0
HKD1_k127_2309349_55 Amidohydrolase family K05603 - 3.5.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 324.0
HKD1_k127_2309349_56 N-formylglutamate amidohydrolase K01458,K01479 - 3.5.1.68,3.5.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004406 307.0
HKD1_k127_2309349_57 FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 306.0
HKD1_k127_2309349_58 Putative zinc-binding metallo-peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 294.0
HKD1_k127_2309349_59 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 284.0
HKD1_k127_2309349_6 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 2.849e-232 740.0
HKD1_k127_2309349_60 carbohydrate metabolic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007316 280.0
HKD1_k127_2309349_61 Protein involved in meta-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007783 279.0
HKD1_k127_2309349_62 Phage tail sheath C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008434 290.0
HKD1_k127_2309349_63 Cysteine-rich domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001588 284.0
HKD1_k127_2309349_64 Peptidase family U32 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000162 295.0
HKD1_k127_2309349_65 Protein of unknown function (DUF3237) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002412 267.0
HKD1_k127_2309349_66 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005768 254.0
HKD1_k127_2309349_67 TIGRFAM Methylated-DNA- protein -cysteine S-methyltransferase, DNA binding K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000003403 259.0
HKD1_k127_2309349_68 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000142 248.0
HKD1_k127_2309349_69 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000001069 248.0
HKD1_k127_2309349_7 peptidase K07386 - - 8.976e-225 719.0
HKD1_k127_2309349_70 TPM domain K06872 - - 0.00000000000000000000000000000000000000000000000000000000000000000004029 246.0
HKD1_k127_2309349_71 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000001336 239.0
HKD1_k127_2309349_72 Prolyl 4-hydroxylase alpha subunit homologues. - - - 0.00000000000000000000000000000000000000000000000000000000000002787 222.0
HKD1_k127_2309349_73 Domain of unknown function (DUF1993) K09983 - - 0.00000000000000000000000000000000000000000000000000000000000005004 218.0
HKD1_k127_2309349_74 PFAM ADP-ribosylation Crystallin J1 K05521 - 3.2.2.24 0.000000000000000000000000000000000000000000000000000000000001024 231.0
HKD1_k127_2309349_75 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000247 214.0
HKD1_k127_2309349_76 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.0000000000000000000000000000000000000000000000000000000003888 207.0
HKD1_k127_2309349_77 myo-inosose-2 dehydratase activity - - - 0.000000000000000000000000000000000000000000000000000000000504 214.0
HKD1_k127_2309349_78 Belongs to the Nudix hydrolase family K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000004631 203.0
HKD1_k127_2309349_79 - - - - 0.00000000000000000000000000000000000000000000000000000001285 220.0
HKD1_k127_2309349_8 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 3.825e-222 722.0
HKD1_k127_2309349_80 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000474 201.0
HKD1_k127_2309349_81 synthase K01737 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0070497,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000000001485 194.0
HKD1_k127_2309349_82 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000003271 213.0
HKD1_k127_2309349_83 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000003789 190.0
HKD1_k127_2309349_84 TPM domain - - - 0.00000000000000000000000000000000000000000007535 164.0
HKD1_k127_2309349_85 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000001454 159.0
HKD1_k127_2309349_86 gag-polyprotein putative aspartyl protease - - - 0.00000000000000000000000000000000000000002002 166.0
HKD1_k127_2309349_87 - - - - 0.000000000000000000000000000000000002751 147.0
HKD1_k127_2309349_88 Small Multidrug Resistance protein - - - 0.00000000000000000000000000000000003031 142.0
HKD1_k127_2309349_89 - - - - 0.00000000000000000000000000000001903 134.0
HKD1_k127_2309349_9 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 6.699e-211 662.0
HKD1_k127_2309349_90 - - - - 0.00000000000000000000000000000002911 134.0
HKD1_k127_2309349_91 Dual specificity phosphatase, catalytic domain - - - 0.00000000000000000000000000000006405 143.0
HKD1_k127_2309349_92 lipid carrier protein - - - 0.0000000000000000000000000000009243 131.0
HKD1_k127_2309349_93 Cupin domain - - - 0.00000000000000000000000000001092 121.0
HKD1_k127_2309349_94 Protein of unknown function (DUF2721) - - - 0.00000000000000000000000000003313 121.0
HKD1_k127_2309349_95 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000248 107.0
HKD1_k127_2309349_96 Thioredoxin - - - 0.0000000000000000000001752 111.0
HKD1_k127_2309349_97 ethyl tert-butyl ether degradation - - - 0.00000000000001231 84.0
HKD1_k127_2309349_98 iron ion homeostasis K04758 - - 0.00000000000001927 77.0
HKD1_k127_2309349_99 COG5608 Conserved secreted protein - - - 0.0000000000003304 76.0
HKD1_k127_2319742_0 amino acid peptide transporter K03305 - - 1.68e-250 780.0
HKD1_k127_2319742_1 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005446 453.0
HKD1_k127_2326371_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1636.0
HKD1_k127_2326371_1 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing - - - 0.0 1206.0
HKD1_k127_2326371_10 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004654 326.0
HKD1_k127_2326371_11 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007879 322.0
HKD1_k127_2326371_12 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000005651 244.0
HKD1_k127_2326371_14 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane K00247 - - 0.00000000000000000000000000000000000000000000008193 179.0
HKD1_k127_2326371_15 Belongs to the GST superfamily K11209 - - 0.0000000000000000000000000000000000000000001214 162.0
HKD1_k127_2326371_16 Fumarate reductase subunit C K00246 - - 0.00000000000000000000000000000000000000002173 167.0
HKD1_k127_2326371_18 Thioesterase superfamily K07107 - - 0.000000000000000000000000001407 117.0
HKD1_k127_2326371_19 thioesterase K01075 - 3.1.2.23 0.000000000000000000000001739 114.0
HKD1_k127_2326371_2 Transketolase, pyrimidine binding domain - - - 0.0 1030.0
HKD1_k127_2326371_20 Thioesterase-like superfamily K07107 - - 0.000000000000000000008637 103.0
HKD1_k127_2326371_3 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00244 - 1.3.5.4 1.334e-314 972.0
HKD1_k127_2326371_4 Metallopeptidase family M24 - - - 2.085e-249 775.0
HKD1_k127_2326371_5 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 529.0
HKD1_k127_2326371_6 PFAM Uroporphyrinogen decarboxylase (URO-D) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 413.0
HKD1_k127_2326371_7 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K00245 - 1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005905 406.0
HKD1_k127_2326371_8 Pyrogallol hydroxytransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 372.0
HKD1_k127_2326371_9 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007249 337.0
HKD1_k127_2329998_0 kinase activity K01007 - 2.7.9.2 1.925e-242 776.0
HKD1_k127_2329998_1 S-adenosylmethionine diacylglycerol 3-amino-3-carboxypropyl transferase K13622 - - 0.000000000000000000000000000000000000000000000000000000000000000001377 233.0
HKD1_k127_2329998_2 ubiE/COQ5 methyltransferase family - - - 0.00002568 49.0
HKD1_k127_2337773_0 N-terminal domain of (some) glycogen debranching enzymes - - - 0.0 1112.0
HKD1_k127_2337773_1 Amidase K02433 - 6.3.5.6,6.3.5.7 1.409e-272 841.0
HKD1_k127_2337773_10 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000001037 219.0
HKD1_k127_2337773_11 PRC-barrel domain - - - 0.0000000000000000000000000000000000000000000000001545 180.0
HKD1_k127_2337773_12 - - - - 0.0000000000000000000000000000000000000000006639 161.0
HKD1_k127_2337773_13 Major facilitator Superfamily - - - 0.000000007846 63.0
HKD1_k127_2337773_2 transcriptional regulator - - - 1.099e-225 711.0
HKD1_k127_2337773_3 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 540.0
HKD1_k127_2337773_4 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 507.0
HKD1_k127_2337773_5 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 476.0
HKD1_k127_2337773_6 methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 365.0
HKD1_k127_2337773_7 Pfam:AmoA K07120 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008346 353.0
HKD1_k127_2337773_8 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 340.0
HKD1_k127_2337773_9 RadC-like JAB domain K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001773 283.0
HKD1_k127_2399579_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009094 473.0
HKD1_k127_2399579_1 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000000000000000000003071 269.0
HKD1_k127_2399579_2 Domain of unknown function (DUF4440) - - - 0.00000000000000000000000000000000006508 142.0
HKD1_k127_2399579_3 PFAM RNP-1 like RNA-binding protein - - - 0.00000000000000000000000000000001247 129.0
HKD1_k127_2399579_4 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00992 - 2.7.7.99 0.00000000000007646 72.0
HKD1_k127_2399579_5 Belongs to the UPF0250 family K09158 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000002 64.0
HKD1_k127_2432192_0 Aminomethyltransferase folate-binding domain K15064 - - 1.029e-199 644.0
HKD1_k127_2432192_1 MFS/sugar transport protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 477.0
HKD1_k127_2432192_2 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 424.0
HKD1_k127_2432192_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007725 317.0
HKD1_k127_2432192_4 FCD K11475 - - 0.00000000000000000000000000000000000000000000000000000000000000009731 229.0
HKD1_k127_2432192_5 - - - - 0.0000000000000000000000000000000000000000000000007574 184.0
HKD1_k127_2432192_6 - - - - 0.00000000000000000000000003252 113.0
HKD1_k127_250991_0 Mechanosensitive ion channel K05802 - - 1.638e-223 721.0
HKD1_k127_250991_1 Cobalt uptake substrate-specific transmembrane region - - - 0.000000000000000000000000002174 117.0
HKD1_k127_2726970_0 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 1.33e-209 668.0
HKD1_k127_2726970_1 Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde K01620 - 4.1.2.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007362 561.0
HKD1_k127_2726970_11 - - - - 0.000000000000000000000004032 116.0
HKD1_k127_2726970_12 - - - - 0.000000000000000002029 97.0
HKD1_k127_2726970_13 Rieske 2Fe-2S - - - 0.0000000000000002341 93.0
HKD1_k127_2726970_14 - - - - 0.0000000000009463 78.0
HKD1_k127_2726970_2 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 329.0
HKD1_k127_2726970_3 nitrite transmembrane transporter activity K08218,K08223 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008967 325.0
HKD1_k127_2726970_4 catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000002037 265.0
HKD1_k127_2726970_5 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000001003 213.0
HKD1_k127_2726970_6 C-terminal domain of histone - - - 0.00000000000000000000000000000000000000000000000000001234 195.0
HKD1_k127_2726970_7 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000005275 170.0
HKD1_k127_2726970_8 - - - - 0.00000000000000000000000000000000000000000008402 172.0
HKD1_k127_2726970_9 Protein of unknown function (DUF3667) - - - 0.0000000000000000000000000000000000000003889 159.0
HKD1_k127_287227_0 Flavin containing amine oxidoreductase - - - 1.753e-251 784.0
HKD1_k127_287227_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 359.0
HKD1_k127_287227_2 Belongs to the GMC oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 290.0
HKD1_k127_287227_3 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001004 287.0
HKD1_k127_2921094_0 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 2.335e-304 951.0
HKD1_k127_2921094_1 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 5.051e-288 895.0
HKD1_k127_2921094_10 COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit K00241 - - 0.0000000000000000000002178 105.0
HKD1_k127_2921094_11 An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH K00240,K09159 GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016043,GO:0016999,GO:0017013,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:1901564 1.3.5.1,1.3.5.4 0.000000000002451 70.0
HKD1_k127_2921094_12 Domain of unknown function (DUF4845) - - - 0.00000000002564 69.0
HKD1_k127_2921094_13 Protein of unknown function (DUF1674) - - - 0.000000001425 63.0
HKD1_k127_2921094_14 PFAM glutaredoxin 2 - - - 0.000000008418 64.0
HKD1_k127_2921094_15 PFAM Anti sigma-E protein RseA K03597 - - 0.00008613 54.0
HKD1_k127_2921094_2 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 397.0
HKD1_k127_2921094_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008645 256.0
HKD1_k127_2921094_4 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000003854 260.0
HKD1_k127_2921094_5 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000006043 232.0
HKD1_k127_2921094_6 MucB/RseB C-terminal domain - - - 0.0000000000000000000000000000000000000000000000009069 189.0
HKD1_k127_2921094_7 Belongs to the GcvT family K06980 - - 0.00000000000000000000000000000008518 132.0
HKD1_k127_2921094_8 succinate dehydrogenase K00242 - - 0.000000000000000000000000005301 122.0
HKD1_k127_2921094_9 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000005832 113.0
HKD1_k127_2957118_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009421 610.0
HKD1_k127_2957118_1 cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 613.0
HKD1_k127_2957118_10 OsmC-like protein K04063 - - 0.00000000000000000000000000000000000000000001028 170.0
HKD1_k127_2957118_11 Type IV pili methyl-accepting chemotaxis transducer N-term - - - 0.0000000000000000000000001901 120.0
HKD1_k127_2957118_12 - - - - 0.00000372 50.0
HKD1_k127_2957118_2 Cobalamin synthesis protein cobW C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006534 444.0
HKD1_k127_2957118_3 Phage integrase, N-terminal SAM-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005532 404.0
HKD1_k127_2957118_4 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 337.0
HKD1_k127_2957118_5 Putative cyclase K07130 - 3.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 297.0
HKD1_k127_2957118_6 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K18954 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002534 251.0
HKD1_k127_2957118_7 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000007212 211.0
HKD1_k127_2957118_8 Alternative locus ID - - - 0.0000000000000000000000000000000000000000000000000008255 202.0
HKD1_k127_298375_0 FAD linked oxidase domain protein K05797 - 1.17.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004265 488.0
HKD1_k127_2998616_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.0 1163.0
HKD1_k127_2998616_1 Belongs to the GcvT family K00302 - 1.5.3.1 5.439e-288 914.0
HKD1_k127_2998616_10 Sarcosine oxidase, gamma subunit K00305 - 1.5.3.1 0.000000000000004702 86.0
HKD1_k127_2998616_2 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005265 542.0
HKD1_k127_2998616_3 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008559 484.0
HKD1_k127_2998616_4 Sulfatase K01137 - 3.1.6.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 477.0
HKD1_k127_2998616_5 Sugar (and other) transporter K08196 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 417.0
HKD1_k127_2998616_6 Arsenate reductase and related K00537 - 1.20.4.1 0.0000000000000000000000000000000000000000000000000243 182.0
HKD1_k127_2998616_7 protein conserved in bacteria K09973 - - 0.00000000000000000000000000000000000000000000006227 180.0
HKD1_k127_2998616_8 Protein of unknown function (DUF3761) - - - 0.000000000000000000000000000000000000004884 149.0
HKD1_k127_2998616_9 Sarcosine oxidase delta subunit K00304 - 1.5.3.1 0.000000000000000000000000001542 129.0
HKD1_k127_3047091_0 ATPase, P-type K01531 - 3.6.3.2 0.0 1064.0
HKD1_k127_3047091_1 formate-tetrahydrofolate ligase activity K01938 - 6.3.4.3 2.533e-301 935.0
HKD1_k127_3047091_10 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 479.0
HKD1_k127_3047091_11 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 455.0
HKD1_k127_3047091_12 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 405.0
HKD1_k127_3047091_13 Dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004123 386.0
HKD1_k127_3047091_14 Transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 351.0
HKD1_k127_3047091_15 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007162 355.0
HKD1_k127_3047091_16 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006094 359.0
HKD1_k127_3047091_17 PFAM Nitrate reductase gamma subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003594 330.0
HKD1_k127_3047091_18 PFAM Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 331.0
HKD1_k127_3047091_19 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 340.0
HKD1_k127_3047091_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812 - 1.7.2.3 2.593e-296 933.0
HKD1_k127_3047091_20 Similarity to COG0437 Fe-S-cluster-containing hydrogenase components 1(Evalue - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 315.0
HKD1_k127_3047091_21 Biotin-lipoyl like K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002689 298.0
HKD1_k127_3047091_22 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002656 288.0
HKD1_k127_3047091_23 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008099 279.0
HKD1_k127_3047091_24 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008424 275.0
HKD1_k127_3047091_25 Similarity to COG0437 Fe-S-cluster-containing hydrogenase components 1(Evalue - - - 0.00000000000000000000000000000000000000000000000000000000000000000003689 241.0
HKD1_k127_3047091_26 helix_turn_helix isocitrate lyase regulation - - - 0.00000000000000000000000000000000000000000000000000000001098 207.0
HKD1_k127_3047091_27 ECF sigma factor - - - 0.00000000000000000000000000000000000000000000000000000009924 201.0
HKD1_k127_3047091_28 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000002327 170.0
HKD1_k127_3047091_29 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000317 160.0
HKD1_k127_3047091_3 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K07812 - 1.7.2.3 3.219e-285 900.0
HKD1_k127_3047091_30 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000006428 157.0
HKD1_k127_3047091_31 DsrC like protein K11179 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000215 158.0
HKD1_k127_3047091_32 Cupin domain - - - 0.0000000000000000000000000000000000009523 148.0
HKD1_k127_3047091_33 gag-polyprotein putative aspartyl protease - - - 0.000000000000000000000000000000000008024 150.0
HKD1_k127_3047091_34 Peptidase M48 Ste24p - - - 0.0000000000000000000000000000000002034 151.0
HKD1_k127_3047091_35 Transglycosylase associated protein - - - 0.000000000000000000000000000002184 121.0
HKD1_k127_3047091_36 - - - - 0.0000000000000000000000000001321 120.0
HKD1_k127_3047091_37 - - - - 0.000000000000000000000000634 108.0
HKD1_k127_3047091_38 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000007551 109.0
HKD1_k127_3047091_39 - - - - 0.0000000000000000004639 92.0
HKD1_k127_3047091_4 4Fe-4S dicluster domain - - - 4.391e-267 831.0
HKD1_k127_3047091_40 - - - - 0.0000000000001462 78.0
HKD1_k127_3047091_41 RsbT co-antagonist protein rsbRD N-terminal domain - - - 0.00000000001125 73.0
HKD1_k127_3047091_42 - - - - 0.00000000007886 72.0
HKD1_k127_3047091_43 Protein of unknown function (DUF2934) - - - 0.0000000002295 64.0
HKD1_k127_3047091_44 Protein required for attachment to host cells - - - 0.000000005469 64.0
HKD1_k127_3047091_45 PAS fold - - - 0.00000009512 63.0
HKD1_k127_3047091_5 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 8.724e-252 787.0
HKD1_k127_3047091_6 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 6.614e-248 790.0
HKD1_k127_3047091_7 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 557.0
HKD1_k127_3047091_8 Methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 511.0
HKD1_k127_3047091_9 Tannase and feruloyl esterase K21105 - 3.1.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 510.0
HKD1_k127_3055275_0 FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 386.0
HKD1_k127_3055275_1 major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 389.0
HKD1_k127_3055275_2 Cysteine-rich domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 365.0
HKD1_k127_3055275_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003525 329.0
HKD1_k127_3055275_4 alcohol dehydrogenase K00055 - 1.1.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004945 320.0
HKD1_k127_3055275_5 protein-(glutamine-N5) methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001657 294.0
HKD1_k127_3055275_6 FAD linked oxidase domain protein K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000008515 213.0
HKD1_k127_3055275_7 cellulose synthase - - - 0.00000000000000000000000000000000000000000436 160.0
HKD1_k127_3055275_8 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.000000000000001885 76.0
HKD1_k127_3059358_0 Glycogen debranching enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 334.0
HKD1_k127_3059358_1 methyltransferase activity - - - 0.000000000000003552 86.0
HKD1_k127_3059358_2 YMGG-like Gly-zipper - - - 0.00000008695 57.0
HKD1_k127_308204_0 Putative transposase - - - 0.00000000000000000000000000000000000000000000000000002693 198.0
HKD1_k127_308204_1 Family of unknown function (DUF5372) - - - 0.00000000000299 74.0
HKD1_k127_308204_2 - - - - 0.0000001669 63.0
HKD1_k127_3087189_0 Dehydrogenase - - - 1.531e-216 689.0
HKD1_k127_3087189_1 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007589 244.0
HKD1_k127_3093630_0 TIGRFAM FeS assembly protein SufB K09014 - - 1.845e-252 788.0
HKD1_k127_3093630_1 TonB dependent receptor - - - 1.432e-212 705.0
HKD1_k127_3093630_10 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006767 450.0
HKD1_k127_3093630_11 Belongs to the class I fructose-bisphosphate aldolase family K01623 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 420.0
HKD1_k127_3093630_12 PFAM NADH flavin oxidoreductase NADH oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001783 380.0
HKD1_k127_3093630_13 FeS assembly ATPase SufC K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 374.0
HKD1_k127_3093630_14 Domain of unknown function DUF21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 384.0
HKD1_k127_3093630_15 proline dipeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005738 372.0
HKD1_k127_3093630_16 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 350.0
HKD1_k127_3093630_17 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019842,GO:0030170,GO:0030203,GO:0034645,GO:0036094,GO:0036361,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0048037,GO:0050662,GO:0070279,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009599 327.0
HKD1_k127_3093630_18 PFAM ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 329.0
HKD1_k127_3093630_19 NnrS protein K07234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 317.0
HKD1_k127_3093630_2 SMART Nucleotide binding protein, PINc K07175 - - 6.111e-203 644.0
HKD1_k127_3093630_20 SMART protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 301.0
HKD1_k127_3093630_21 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 299.0
HKD1_k127_3093630_22 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 297.0
HKD1_k127_3093630_23 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006021 289.0
HKD1_k127_3093630_24 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007887 288.0
HKD1_k127_3093630_25 Belongs to the peptidase S41A family K03797 GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001533 289.0
HKD1_k127_3093630_26 ABC transporter permease K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005827 278.0
HKD1_k127_3093630_27 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006995 293.0
HKD1_k127_3093630_28 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000006731 275.0
HKD1_k127_3093630_29 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005013 261.0
HKD1_k127_3093630_3 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 540.0
HKD1_k127_3093630_30 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004513 253.0
HKD1_k127_3093630_31 TIGRFAM FeS assembly SUF system protein SufT - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008668 246.0
HKD1_k127_3093630_32 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000000000001416 248.0
HKD1_k127_3093630_33 AAA domain K07028 - - 0.00000000000000000000000000000000000000000000000000000000000000001359 243.0
HKD1_k127_3093630_34 Uncharacterised MFS-type transporter YbfB K05548,K05819,K08195 - - 0.00000000000000000000000000000000000000000000000000000000000000001384 242.0
HKD1_k127_3093630_35 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000002279 233.0
HKD1_k127_3093630_36 Isochorismatase family K08281 - 3.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000006466 228.0
HKD1_k127_3093630_37 (FHA) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000826 223.0
HKD1_k127_3093630_38 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000002597 208.0
HKD1_k127_3093630_39 Lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000002816 205.0
HKD1_k127_3093630_4 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004685 548.0
HKD1_k127_3093630_40 PFAM Amino acid-binding ACT K03567 - - 0.00000000000000000000000000000000000000000000000000000239 196.0
HKD1_k127_3093630_41 Phosphoribosyl transferase domain K07100 - - 0.000000000000000000000000000000000000000000000000000002765 201.0
HKD1_k127_3093630_42 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000000000000000716 183.0
HKD1_k127_3093630_43 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000007862 181.0
HKD1_k127_3093630_44 Peroxiredoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000001018 192.0
HKD1_k127_3093630_45 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000000000000000000000000000000003003 175.0
HKD1_k127_3093630_46 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000000000000009082 180.0
HKD1_k127_3093630_47 MlaD protein K02067 - - 0.00000000000000000000000000000000000000002192 157.0
HKD1_k127_3093630_48 ABC-type transport system involved in resistance to organic solvents auxiliary component K07323 - - 0.000000000000000000000000000000000000006123 160.0
HKD1_k127_3093630_49 abc transporter, permease K09015 - - 0.00000000000000000000000000000000000009896 158.0
HKD1_k127_3093630_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006023 530.0
HKD1_k127_3093630_50 transcriptional regulator - - - 0.00000000000000000000000000000000001744 140.0
HKD1_k127_3093630_51 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000001869 139.0
HKD1_k127_3093630_52 RimM N-terminal domain K02860 - - 0.000000000000000000000000000007834 125.0
HKD1_k127_3093630_53 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000108 128.0
HKD1_k127_3093630_54 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000002585 114.0
HKD1_k127_3093630_55 protein conserved in bacteria K09920 - - 0.0000000000000000000000005272 110.0
HKD1_k127_3093630_56 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.00000000001139 77.0
HKD1_k127_3093630_57 Haem-degrading - - - 0.0000000004566 69.0
HKD1_k127_3093630_58 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00162,K21417 - 1.2.4.1 0.000000003721 57.0
HKD1_k127_3093630_59 NTP binding protein (Contains STAS domain) K07122 - - 0.00000002714 59.0
HKD1_k127_3093630_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008577 516.0
HKD1_k127_3093630_7 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008955 476.0
HKD1_k127_3093630_8 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007265 475.0
HKD1_k127_3093630_9 signal peptide peptidase K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005042 462.0
HKD1_k127_3099034_0 Surface antigen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007913 276.0
HKD1_k127_3099034_1 Cupin - - - 0.00000000000000000000000000000000000000000000000000000000000000003846 225.0
HKD1_k127_3099034_2 MarR family - - - 0.0000000000000000000000000000000000000000000000000000000006464 205.0
HKD1_k127_3099034_3 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000006045 186.0
HKD1_k127_3099034_4 Domain of unknown function (DUF202) - - - 0.00000000007646 70.0
HKD1_k127_3099034_5 - - - - 0.000001113 59.0
HKD1_k127_3106309_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1281.0
HKD1_k127_3106309_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1113.0
HKD1_k127_3106309_10 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002708 481.0
HKD1_k127_3106309_11 glutamine synthetase K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 461.0
HKD1_k127_3106309_12 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 459.0
HKD1_k127_3106309_13 Histidine kinase K02668 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007113 369.0
HKD1_k127_3106309_14 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 340.0
HKD1_k127_3106309_15 ZIP Zinc transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002113 266.0
HKD1_k127_3106309_16 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005136 271.0
HKD1_k127_3106309_17 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000005739 227.0
HKD1_k127_3106309_18 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000000006843 231.0
HKD1_k127_3106309_19 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000000000000000000000000000000000001426 191.0
HKD1_k127_3106309_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 3.436e-316 992.0
HKD1_k127_3106309_20 nucleosidase K01243 - 3.2.2.9 0.000000000000000000000000000000000000000000000002993 179.0
HKD1_k127_3106309_21 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000003668 179.0
HKD1_k127_3106309_22 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000007945 167.0
HKD1_k127_3106309_23 Belongs to the CinA family K03743 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811,GO:0019159 3.5.1.42 0.0000000000000000000000000000000000000000006458 167.0
HKD1_k127_3106309_24 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000002694 166.0
HKD1_k127_3106309_25 Belongs to the N-Me-Phe pilin family K02650 - - 0.000000000000000000000000007658 112.0
HKD1_k127_3106309_26 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0008452,GO:0008664,GO:0016787,GO:0016788,GO:0016874,GO:0016886,GO:0042578,GO:0140098 3.1.4.58 0.000000000000000000000004098 110.0
HKD1_k127_3106309_27 Modulates RecA activity K03565 - - 0.000000000000000000000008142 110.0
HKD1_k127_3106309_28 Regulatory protein, FmdB family - - - 0.0000000000000000000006078 100.0
HKD1_k127_3106309_29 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding K03563 - - 0.00000000000000308 79.0
HKD1_k127_3106309_3 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 8.13e-261 816.0
HKD1_k127_3106309_4 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 1.143e-255 814.0
HKD1_k127_3106309_5 Domain of Unknown Function (DUF748) - - - 3.666e-219 718.0
HKD1_k127_3106309_6 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 612.0
HKD1_k127_3106309_7 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 554.0
HKD1_k127_3106309_8 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000387 523.0
HKD1_k127_3106309_9 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 497.0
HKD1_k127_3139343_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1320.0
HKD1_k127_3139343_1 glutamate synthase - - - 0.0 1194.0
HKD1_k127_3139343_10 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 2.458e-257 807.0
HKD1_k127_3139343_100 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000000000000000000000000000000000000001596 168.0
HKD1_k127_3139343_101 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000000000000000005796 168.0
HKD1_k127_3139343_102 methyltransferase - - - 0.000000000000000000000000000000000000000000008144 169.0
HKD1_k127_3139343_103 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000000000001005 171.0
HKD1_k127_3139343_104 oxidase assembly K02258 - - 0.0000000000000000000000000000000000000000002212 164.0
HKD1_k127_3139343_106 assembly protein (PilN) K02663 - - 0.000000000000000000000000000000000000000006695 161.0
HKD1_k127_3139343_107 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000000000000000000001581 162.0
HKD1_k127_3139343_108 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000005876 157.0
HKD1_k127_3139343_109 pilus assembly protein PilP K02665 - - 0.0000000000000000000000000000000000000001197 156.0
HKD1_k127_3139343_11 highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues K01915 - 6.3.1.2 4.369e-251 781.0
HKD1_k127_3139343_110 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000001216 165.0
HKD1_k127_3139343_111 (twin-arginine translocation) pathway signal - - - 0.0000000000000000000000000000000000000001428 159.0
HKD1_k127_3139343_112 SURF1-like protein - - - 0.0000000000000000000000000000000000001159 154.0
HKD1_k127_3139343_113 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 GO:0002790,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0043952,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051082,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0072321 - 0.0000000000000000000000000000000000008272 149.0
HKD1_k127_3139343_114 Competence protein - - - 0.00000000000000000000000000000000002025 145.0
HKD1_k127_3139343_115 PFAM cytochrome c, class I - - - 0.00000000000000000000000000000000006494 140.0
HKD1_k127_3139343_116 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000000000000000000000000001178 134.0
HKD1_k127_3139343_117 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000000000002234 136.0
HKD1_k127_3139343_118 Membrane protein implicated in regulation of membrane protease activity K07340 - - 0.0000000000000000000000000000000003419 141.0
HKD1_k127_3139343_119 Thiol disulfide interchange protein K03673 - - 0.00000000000000000000000000000003616 139.0
HKD1_k127_3139343_12 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 1.65e-247 784.0
HKD1_k127_3139343_120 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0033218,GO:0042277,GO:0043167,GO:0043168,GO:0043295,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0055114,GO:0072341,GO:1900750,GO:1901681 - 0.000000000000000000000000000001369 123.0
HKD1_k127_3139343_121 50S ribosomal protein L31 K02909 - - 0.000000000000000000000000000002963 123.0
HKD1_k127_3139343_122 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000008539 124.0
HKD1_k127_3139343_123 - - - - 0.0000000000000000000000000000164 137.0
HKD1_k127_3139343_124 Could be involved in insertion of integral membrane proteins into the membrane K08998 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - 0.0000000000000000000000000005277 117.0
HKD1_k127_3139343_125 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses K01179,K01637 - 3.2.1.4,4.1.3.1 0.000000000000000000000000003421 124.0
HKD1_k127_3139343_126 Rhodanese Homology Domain - - - 0.00000000000000000000000009825 111.0
HKD1_k127_3139343_127 signal sequence binding - - - 0.0000000000000000000003422 111.0
HKD1_k127_3139343_128 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000002318 98.0
HKD1_k127_3139343_129 bacterial-type flagellum-dependent cell motility K01278,K02388,K02396,K03561,K12287 - 3.4.14.5 0.00000000000000000001389 104.0
HKD1_k127_3139343_13 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 6.719e-247 782.0
HKD1_k127_3139343_130 Cytochrome c - - - 0.00000000000000000004868 104.0
HKD1_k127_3139343_131 COG0457 FOG TPR repeat - - - 0.0000000000000000001673 95.0
HKD1_k127_3139343_132 Protein of unknown function (DUF3293) - - - 0.000000000000000008598 94.0
HKD1_k127_3139343_133 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000037 76.0
HKD1_k127_3139343_134 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.0000000000007908 73.0
HKD1_k127_3139343_135 Domain of unknown function (DUF4124) - - - 0.000000000001142 75.0
HKD1_k127_3139343_136 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 GO:0002790,GO:0003674,GO:0005215,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705 - 0.00000000005155 66.0
HKD1_k127_3139343_137 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000001166 73.0
HKD1_k127_3139343_138 ATP synthase I chain K02116 - - 0.000000005228 63.0
HKD1_k127_3139343_139 Protein of unknown function (DUF2909) - - - 0.00000003371 65.0
HKD1_k127_3139343_14 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 2.084e-241 754.0
HKD1_k127_3139343_140 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000001179 61.0
HKD1_k127_3139343_141 EamA-like transporter family - - - 0.00001365 57.0
HKD1_k127_3139343_142 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00001389 54.0
HKD1_k127_3139343_15 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 1.131e-238 770.0
HKD1_k127_3139343_16 TIGRFAM penicillin-binding protein, 1A K05366 - 2.4.1.129,3.4.16.4 2.335e-234 752.0
HKD1_k127_3139343_17 Glycosyltransferase family 20 K00697 - 2.4.1.15,2.4.1.347 1.153e-220 709.0
HKD1_k127_3139343_18 Glycosyl hydrolases family 15 - - - 2.289e-217 694.0
HKD1_k127_3139343_19 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 3.45e-204 659.0
HKD1_k127_3139343_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1111.0
HKD1_k127_3139343_20 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 5.374e-196 620.0
HKD1_k127_3139343_21 Belongs to the citrate synthase family K01647 - 2.3.3.1 6.774e-194 613.0
HKD1_k127_3139343_22 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004851 599.0
HKD1_k127_3139343_23 belongs to the aldehyde dehydrogenase family K00146 - 1.2.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006395 591.0
HKD1_k127_3139343_24 SpoVR like protein K06415 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004572 580.0
HKD1_k127_3139343_25 nitrogen regulation protein NR(I) K07712 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003746 567.0
HKD1_k127_3139343_26 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 562.0
HKD1_k127_3139343_27 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 533.0
HKD1_k127_3139343_28 TrkA-N domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005038 541.0
HKD1_k127_3139343_29 glycyl-tRNA synthetase, alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 498.0
HKD1_k127_3139343_3 Protein of unknown function (DUF3604) - - - 0.0 1092.0
HKD1_k127_3139343_30 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006929 488.0
HKD1_k127_3139343_31 TIGRFAM amino acid peptide transporter (Peptide H symporter), bacterial K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003013 467.0
HKD1_k127_3139343_32 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000068 457.0
HKD1_k127_3139343_33 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 451.0
HKD1_k127_3139343_34 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 445.0
HKD1_k127_3139343_35 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 439.0
HKD1_k127_3139343_36 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 434.0
HKD1_k127_3139343_37 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005623 416.0
HKD1_k127_3139343_38 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 417.0
HKD1_k127_3139343_39 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005941 405.0
HKD1_k127_3139343_4 Glycosyl transferase family 21 - - - 0.0 1057.0
HKD1_k127_3139343_40 Belongs to the UPF0229 family K09786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006609 402.0
HKD1_k127_3139343_41 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000776 418.0
HKD1_k127_3139343_42 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 394.0
HKD1_k127_3139343_43 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007288 379.0
HKD1_k127_3139343_44 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 377.0
HKD1_k127_3139343_45 Heme copper-type cytochrome quinol oxidase subunit 3 K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 366.0
HKD1_k127_3139343_46 PFAM methylamine dehydrogenase heavy subunit K13372,K15229 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.4.9.1,1.4.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 370.0
HKD1_k127_3139343_47 Pilus assembly protein K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006217 360.0
HKD1_k127_3139343_48 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004848 354.0
HKD1_k127_3139343_49 type IV pilus secretin PilQ K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 359.0
HKD1_k127_3139343_5 PFAM PrkA AAA K07180 - - 3.48e-300 935.0
HKD1_k127_3139343_50 Glycerol-3-phosphate dehydrogenase K00057 GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006708 342.0
HKD1_k127_3139343_51 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 336.0
HKD1_k127_3139343_52 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 335.0
HKD1_k127_3139343_53 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 334.0
HKD1_k127_3139343_54 signal transduction histidine kinase K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003109 332.0
HKD1_k127_3139343_55 Belongs to the ParB family K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 326.0
HKD1_k127_3139343_56 HupE / UreJ protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002571 331.0
HKD1_k127_3139343_57 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007525 338.0
HKD1_k127_3139343_58 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008142 327.0
HKD1_k127_3139343_59 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 304.0
HKD1_k127_3139343_6 PFAM UvrD REP helicase K03657 - 3.6.4.12 1.518e-295 923.0
HKD1_k127_3139343_60 glutamate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003876 301.0
HKD1_k127_3139343_61 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007941 301.0
HKD1_k127_3139343_62 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008159 302.0
HKD1_k127_3139343_63 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007367 291.0
HKD1_k127_3139343_64 Diguanylate cyclase K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006648 309.0
HKD1_k127_3139343_65 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006874 287.0
HKD1_k127_3139343_66 cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001556 285.0
HKD1_k127_3139343_67 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002207 304.0
HKD1_k127_3139343_68 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002181 275.0
HKD1_k127_3139343_69 PFAM YicC-like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003013 272.0
HKD1_k127_3139343_7 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 2.158e-278 869.0
HKD1_k127_3139343_70 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002242 272.0
HKD1_k127_3139343_71 PFAM Methylamine dehydrogenase light chain K13371,K15228 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.4.9.1,1.4.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000001582 263.0
HKD1_k127_3139343_72 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000000001892 258.0
HKD1_k127_3139343_73 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002107 259.0
HKD1_k127_3139343_74 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001179 250.0
HKD1_k127_3139343_75 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000004102 243.0
HKD1_k127_3139343_76 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000001619 240.0
HKD1_k127_3139343_77 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001747 241.0
HKD1_k127_3139343_78 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000008961 233.0
HKD1_k127_3139343_79 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000001355 232.0
HKD1_k127_3139343_8 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 2.283e-265 829.0
HKD1_k127_3139343_80 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000005831 231.0
HKD1_k127_3139343_81 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000003978 232.0
HKD1_k127_3139343_82 PFAM peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000007921 233.0
HKD1_k127_3139343_83 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 0.00000000000000000000000000000000000000000000000000000000000009811 215.0
HKD1_k127_3139343_84 Pilus assembly protein, PilO K02664 - - 0.0000000000000000000000000000000000000000000000000000000005732 209.0
HKD1_k127_3139343_85 PPIC-type PPIASE domain - - - 0.000000000000000000000000000000000000000000000000000000002655 212.0
HKD1_k127_3139343_86 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000000000000000000005324 206.0
HKD1_k127_3139343_87 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000009059 209.0
HKD1_k127_3139343_88 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000111 208.0
HKD1_k127_3139343_89 Protein of unknown function (DUF3237) - - - 0.00000000000000000000000000000000000000000000000000000002413 202.0
HKD1_k127_3139343_9 - - - - 1.369e-258 845.0
HKD1_k127_3139343_90 COG1073 hydrolases of the alpha beta superfamily - - - 0.0000000000000000000000000000000000000000000000000000003649 203.0
HKD1_k127_3139343_91 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000000000000002271 199.0
HKD1_k127_3139343_92 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.000000000000000000000000000000000000000000000000000002362 199.0
HKD1_k127_3139343_93 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000000000000000006926 200.0
HKD1_k127_3139343_94 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000003027 194.0
HKD1_k127_3139343_95 The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters K02170 - 3.1.1.85 0.000000000000000000000000000000000000000000000000002329 199.0
HKD1_k127_3139343_96 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.000000000000000000000000000000000000000000000000007524 203.0
HKD1_k127_3139343_97 mRNA catabolic process - - - 0.0000000000000000000000000000000000000000000000001487 185.0
HKD1_k127_3139343_98 Protein of unknown function (DUF3237) - - - 0.00000000000000000000000000000000000000000000005826 183.0
HKD1_k127_3139343_99 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000002447 172.0
HKD1_k127_3260840_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 529.0
HKD1_k127_3260840_1 Enoyl-(Acyl carrier protein) reductase K13774 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 401.0
HKD1_k127_3260840_2 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 382.0
HKD1_k127_3260840_3 Transcriptional regulator K07666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 293.0
HKD1_k127_3260840_4 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000001255 228.0
HKD1_k127_3260840_5 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000008601 198.0
HKD1_k127_3260840_6 Carboxyl transferase domain K13778 - 6.4.1.5 0.0000000000000000000001823 110.0
HKD1_k127_3262715_0 L,D-transpeptidase catalytic domain K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006496 488.0
HKD1_k127_3262715_1 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000002756 168.0
HKD1_k127_3379751_0 Belongs to the GMC oxidoreductase family - - - 7.113e-194 619.0
HKD1_k127_3379751_1 GMC oxidoreductase K03333 - 1.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 617.0
HKD1_k127_3379751_10 - - - - 0.000002943 53.0
HKD1_k127_3379751_11 Outer membrane protein beta-barrel domain - - - 0.00005615 53.0
HKD1_k127_3379751_2 Protein of unknown function (DUF3300) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 371.0
HKD1_k127_3379751_3 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 379.0
HKD1_k127_3379751_4 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000457 350.0
HKD1_k127_3379751_5 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000000003982 149.0
HKD1_k127_3379751_6 Protein of unknown function (DUF4242) - - - 0.0000000000000000000000000000000001658 141.0
HKD1_k127_3379751_7 Pterin binding enzyme - - - 0.00000000000000001191 85.0
HKD1_k127_3379751_8 Nuclear transport factor 2 (NTF2) domain - - - 0.00000000000000007 87.0
HKD1_k127_3379751_9 - - - - 0.00000000000000007373 89.0
HKD1_k127_3437896_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1697.0
HKD1_k127_3437896_1 Dehydrogenase K17760 - 1.1.9.1 7.051e-281 880.0
HKD1_k127_3437896_10 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 465.0
HKD1_k127_3437896_11 DNA repair photolyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 441.0
HKD1_k127_3437896_12 Amidohydrolase K07045,K14333,K20941 - 4.1.1.103,4.1.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 436.0
HKD1_k127_3437896_13 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 430.0
HKD1_k127_3437896_14 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 411.0
HKD1_k127_3437896_15 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 409.0
HKD1_k127_3437896_16 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 394.0
HKD1_k127_3437896_17 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000191 406.0
HKD1_k127_3437896_18 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004804 387.0
HKD1_k127_3437896_19 Glutathione S-transferase, C-terminal domain K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005277 361.0
HKD1_k127_3437896_2 Acetolactate synthase K01652 - 2.2.1.6 1.103e-280 873.0
HKD1_k127_3437896_20 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 345.0
HKD1_k127_3437896_21 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 322.0
HKD1_k127_3437896_22 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 315.0
HKD1_k127_3437896_23 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 297.0
HKD1_k127_3437896_24 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008897 285.0
HKD1_k127_3437896_25 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005585 286.0
HKD1_k127_3437896_26 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004161 285.0
HKD1_k127_3437896_28 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000005201 231.0
HKD1_k127_3437896_29 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000001832 235.0
HKD1_k127_3437896_3 Dehydrogenase K17760,K21676 - 1.1.9.1,1.17.2.2 4.026e-237 754.0
HKD1_k127_3437896_30 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000005829 231.0
HKD1_k127_3437896_31 NADPH-dependent FMN reductase K00299 - 1.5.1.38 0.00000000000000000000000000000000000000000000000000000000000009255 220.0
HKD1_k127_3437896_32 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.0000000000000000000000000000000000000000000000000000000003951 215.0
HKD1_k127_3437896_33 Nucleoside-diphosphate-sugar epimerases - - - 0.0000000000000000000000000000000000000000000000000009159 191.0
HKD1_k127_3437896_34 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000001563 198.0
HKD1_k127_3437896_35 Acetolactate synthase small K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000001535 167.0
HKD1_k127_3437896_36 FAD linked oxidase K05797 - 1.17.99.1 0.000000000000000000000000000000000000000001759 162.0
HKD1_k127_3437896_37 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000000005715 152.0
HKD1_k127_3437896_38 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000544 146.0
HKD1_k127_3437896_39 - - - - 0.0000000000000000000000000001354 128.0
HKD1_k127_3437896_4 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 2.1e-236 743.0
HKD1_k127_3437896_40 - - - - 0.00000000000000000000002725 108.0
HKD1_k127_3437896_41 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000006858 108.0
HKD1_k127_3437896_42 - - - - 0.0000000000000000187 90.0
HKD1_k127_3437896_43 Inner membrane component of T3SS, cytoplasmic domain K01990,K21397 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008150,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0030312,GO:0031224,GO:0042623,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.000000000002757 80.0
HKD1_k127_3437896_44 Biotin-requiring enzyme - - - 0.0000000002343 73.0
HKD1_k127_3437896_45 Cytochrome C oxidase, cbb3-type, subunit III K20200 - - 0.000000001341 66.0
HKD1_k127_3437896_46 PFAM alpha beta hydrolase fold - - - 0.000000003227 66.0
HKD1_k127_3437896_5 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 4.276e-218 687.0
HKD1_k127_3437896_6 Outer membrane receptor proteins mostly Fe transport K02014 - - 1.065e-201 653.0
HKD1_k127_3437896_7 FAD linked oxidase domain protein K05797 - 1.17.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 614.0
HKD1_k127_3437896_8 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 544.0
HKD1_k127_3437896_9 Alcohol dehydrogenase GroES-like domain K00098 - 1.1.1.264 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 494.0
HKD1_k127_3451918_0 Activates fatty acids by binding to coenzyme A K01897 - 6.2.1.3 7.525e-219 692.0
HKD1_k127_3451918_1 PQQ-like domain K05889 - 1.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007602 477.0
HKD1_k127_3451918_2 Belongs to the aldehyde dehydrogenase family K00154 - 1.2.1.68 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009788 460.0
HKD1_k127_3451918_3 PFAM Dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 312.0
HKD1_k127_3451918_4 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000006073 273.0
HKD1_k127_3451918_5 Cupin 2, conserved barrel domain protein K11312 - - 0.000000000000002066 85.0
HKD1_k127_3469541_0 dehydrogenase, E1 component K11381 - 1.2.4.4 7.037e-267 850.0
HKD1_k127_3469541_1 Acyl-CoA dehydrogenase, N-terminal domain K00252 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.3.8.6 1.199e-209 657.0
HKD1_k127_3469541_10 Methylamine dehydrogenase accessory protein MauD - - - 0.00000000000000000000000000000000000000000000000000000000000000118 224.0
HKD1_k127_3469541_11 PFAM Methylamine dehydrogenase light chain K13371,K15228 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.4.9.1,1.4.9.2 0.00000000000000000000000000000000000000000000000000000000000207 214.0
HKD1_k127_3469541_12 COG1522 Transcriptional regulators K03719,K05800 - - 0.0000000000000000000000000000000000000008935 154.0
HKD1_k127_3469541_13 Cytochrome c - - - 0.000000000000000000000001164 111.0
HKD1_k127_3469541_14 Methylamine utilisation protein MauE - - - 0.00000000000000000000001023 115.0
HKD1_k127_3469541_15 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.00000000000269 69.0
HKD1_k127_3469541_16 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000008418 59.0
HKD1_k127_3469541_2 Belongs to the thiolase family K00632 - 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 571.0
HKD1_k127_3469541_3 carnitine dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009323 534.0
HKD1_k127_3469541_4 belongs to the aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008342 536.0
HKD1_k127_3469541_5 Voltage gated chloride channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 413.0
HKD1_k127_3469541_6 Pfam:Kce K18013 - 2.3.1.247 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 399.0
HKD1_k127_3469541_7 Methylamine dehydrogenase heavy chain (MADH) K15229 - 1.4.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 309.0
HKD1_k127_3469541_8 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008874 275.0
HKD1_k127_3469541_9 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001079 269.0
HKD1_k127_4033106_0 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 3.941e-309 973.0
HKD1_k127_4033106_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001025 253.0
HKD1_k127_4033106_2 Guanylyl transferase CofC like K14941 - 2.7.7.68 0.00000000000000000000000006103 115.0
HKD1_k127_4097409_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1110.0
HKD1_k127_4097409_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 4.588e-206 653.0
HKD1_k127_4097409_10 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000002681 145.0
HKD1_k127_4097409_11 PFAM methyltransferase - - - 0.00000000000000000000000000000006204 134.0
HKD1_k127_4097409_12 - - - - 0.0000000000000000000009013 105.0
HKD1_k127_4097409_13 - - - - 0.000000000000000001691 91.0
HKD1_k127_4097409_2 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 427.0
HKD1_k127_4097409_3 Catalyzes a key regulatory step in fatty acid biosynthesis K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 351.0
HKD1_k127_4097409_4 serine protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 324.0
HKD1_k127_4097409_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004572 280.0
HKD1_k127_4097409_6 peptidylprolyl isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000008989 281.0
HKD1_k127_4097409_7 epimerase dehydratase K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000002684 214.0
HKD1_k127_4097409_8 RNase H K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000119 210.0
HKD1_k127_4097409_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000003942 190.0
HKD1_k127_410712_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 5.783e-228 724.0
HKD1_k127_410712_1 O-methyltransferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004744 451.0
HKD1_k127_410712_2 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004391 389.0
HKD1_k127_410712_3 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006191 367.0
HKD1_k127_410712_4 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002822 279.0
HKD1_k127_410712_5 rhamnose metabolic process - - - 0.000000000000000000000000000001019 126.0
HKD1_k127_410712_6 SnoaL-like domain - - - 0.0001461 47.0
HKD1_k127_421282_0 Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 577.0
HKD1_k127_421282_1 Alpha/beta hydrolase family K01259 - 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 532.0
HKD1_k127_421282_10 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004268 299.0
HKD1_k127_421282_11 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 283.0
HKD1_k127_421282_12 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001458 282.0
HKD1_k127_421282_13 FR47-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001069 280.0
HKD1_k127_421282_14 CAAX protease self-immunity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002628 286.0
HKD1_k127_421282_15 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001487 265.0
HKD1_k127_421282_16 Appr-1'-p processing enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000007063 246.0
HKD1_k127_421282_17 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001673 234.0
HKD1_k127_421282_18 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000000000000000000000004683 243.0
HKD1_k127_421282_19 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000000000000000000000000000000000000000000001253 224.0
HKD1_k127_421282_2 Homocysteine S-methyltransferase K00547 - 2.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003929 437.0
HKD1_k127_421282_20 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000000000000000009864 222.0
HKD1_k127_421282_21 tRNA m6t6A37 methyltransferase activity K11261 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000003429 206.0
HKD1_k127_421282_22 - - - - 0.00000000000000000000000000000000000000000000000000000001482 205.0
HKD1_k127_421282_23 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000004422 194.0
HKD1_k127_421282_24 Protein of Unknown function (DUF2784) - - - 0.00000000000000000000000000000000000000000000000000009736 191.0
HKD1_k127_421282_25 enzyme of the cupin superfamily K06995 - - 0.00000000000000000000000000000000000000000000000001917 181.0
HKD1_k127_421282_26 Retinal pigment epithelial membrane protein K11159 - - 0.0000000000000000000000000000000000000000000000002777 179.0
HKD1_k127_421282_27 Copper resistance protein D - - - 0.000000000000000000000000000000000000000000000001772 179.0
HKD1_k127_421282_28 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000004983 185.0
HKD1_k127_421282_29 acetyltransferase K22441 - 2.3.1.57 0.0000000000000000000000000000000000000000000003343 176.0
HKD1_k127_421282_3 Beta-eliminating lyase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004166 435.0
HKD1_k127_421282_30 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000005896 170.0
HKD1_k127_421282_31 acetyltransferase - GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 - 0.000000000000000000000000000000000000000000008028 167.0
HKD1_k127_421282_32 FR47-like protein - - - 0.000000000000000000000000000000000000000002461 161.0
HKD1_k127_421282_33 heme oxygenase (decyclizing) activity - - - 0.0000000000000000000000000000000000000003057 157.0
HKD1_k127_421282_34 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000000000001455 149.0
HKD1_k127_421282_35 Bacterial transcription activator, effector binding domain K13652 - - 0.00000000000000000000000000000000002552 139.0
HKD1_k127_421282_36 polyketide cyclase - - - 0.000000000000000000000000000000004035 133.0
HKD1_k127_421282_37 MAPEG family - - - 0.000000000000000000000000000000009162 133.0
HKD1_k127_421282_38 MOSC domain - - - 0.00000000000000000000000000000001672 135.0
HKD1_k127_421282_39 Protein of unknown function (DUF3175) - - - 0.0000000000000000000000000000005531 130.0
HKD1_k127_421282_4 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 394.0
HKD1_k127_421282_40 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000002013 128.0
HKD1_k127_421282_41 Cupin 2, conserved barrel - - - 0.0000000000000000000000001026 115.0
HKD1_k127_421282_42 Predicted small integral membrane protein (DUF2165) - - - 0.000000000000000000000007357 107.0
HKD1_k127_421282_43 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000005974 97.0
HKD1_k127_421282_45 Domain of unknown function (DUF4386) - - - 0.00000000000003071 81.0
HKD1_k127_421282_46 alcohol dehydrogenase K00121 - 1.1.1.1,1.1.1.284 0.00000000001454 68.0
HKD1_k127_421282_48 Protein of unknown function (DUF2845) - - - 0.00003844 55.0
HKD1_k127_421282_49 - - - - 0.00008743 55.0
HKD1_k127_421282_5 PFAM aldo keto reductase K05882 - 1.1.1.91 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 392.0
HKD1_k127_421282_50 - - - - 0.0001529 54.0
HKD1_k127_421282_51 Domain of unknown function (DUF3291) - - - 0.0006046 44.0
HKD1_k127_421282_6 Amidase K21801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002971 391.0
HKD1_k127_421282_7 PFAM flavin reductase domain protein FMN-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 307.0
HKD1_k127_421282_8 Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006816 305.0
HKD1_k127_421282_9 Protein of unknown function (DUF1211) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 292.0
HKD1_k127_4305552_0 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00167 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005552 549.0
HKD1_k127_4305552_1 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 520.0
HKD1_k127_4305552_2 e3 binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 397.0
HKD1_k127_4305552_3 Pterin binding enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 309.0
HKD1_k127_4305552_4 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.0000000000000000000000000000000000002364 144.0
HKD1_k127_4305552_5 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03972 GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0016740,GO:0016782,GO:0016783,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - 0.00000000000000000000643 99.0
HKD1_k127_4446372_0 Uncharacterised conserved protein (DUF2156) K07027,K14205 - 2.3.2.3 2.947e-245 784.0
HKD1_k127_4446372_1 Virulence protein - - - 0.00000000000000000000000000000000000005897 165.0
HKD1_k127_4680886_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1594.0
HKD1_k127_4680886_1 Heat shock 70 kDa protein K04043 - - 1.457e-311 964.0
HKD1_k127_4680886_10 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 504.0
HKD1_k127_4680886_11 Patatin-like phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 456.0
HKD1_k127_4680886_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 438.0
HKD1_k127_4680886_13 ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 419.0
HKD1_k127_4680886_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 377.0
HKD1_k127_4680886_15 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007585 309.0
HKD1_k127_4680886_16 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 306.0
HKD1_k127_4680886_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 289.0
HKD1_k127_4680886_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004164 271.0
HKD1_k127_4680886_19 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000000000000000000001678 265.0
HKD1_k127_4680886_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.129e-294 916.0
HKD1_k127_4680886_20 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001589 257.0
HKD1_k127_4680886_21 BNR repeat-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001303 264.0
HKD1_k127_4680886_22 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000003363 248.0
HKD1_k127_4680886_23 Dihydrodipicolinate reductase, C-terminus K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000001006 234.0
HKD1_k127_4680886_24 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000000000000000002517 215.0
HKD1_k127_4680886_25 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000000000000000000005549 192.0
HKD1_k127_4680886_26 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000002743 167.0
HKD1_k127_4680886_27 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.000000000000000000000000000000015 138.0
HKD1_k127_4680886_28 RNA-binding protein K07574 - - 0.0000000000000000000001663 100.0
HKD1_k127_4680886_29 Preprotein translocase, subunit SecG K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000002394 91.0
HKD1_k127_4680886_3 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 3.063e-263 825.0
HKD1_k127_4680886_30 - - - - 0.000000001211 60.0
HKD1_k127_4680886_31 response to antibiotic - - - 0.00004773 53.0
HKD1_k127_4680886_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 3.387e-234 729.0
HKD1_k127_4680886_5 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 1.148e-233 759.0
HKD1_k127_4680886_6 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 6.333e-219 689.0
HKD1_k127_4680886_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 8.518e-203 638.0
HKD1_k127_4680886_8 Belongs to the CarA family K01956 GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 563.0
HKD1_k127_4680886_9 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 506.0
HKD1_k127_4790337_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002401 504.0
HKD1_k127_4790337_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002927 286.0
HKD1_k127_4790337_2 COG2005 N-terminal domain of molybdenum-binding protein K02019 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000001156 251.0
HKD1_k127_4790337_3 Lipoprotein - - - 0.000000000000000000000000000000000000000000000000002717 188.0
HKD1_k127_4790337_4 COG4149 ABC-type molybdate transport system, permease component K02018 - - 0.000000000000000000804 98.0
HKD1_k127_4790337_5 - - - - 0.00000004526 54.0
HKD1_k127_5111618_0 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 389.0
HKD1_k127_5111618_1 Prokaryotic diacylglycerol kinase K00901 - 2.7.1.107 0.00000000000000000000000000004807 120.0
HKD1_k127_5111618_2 Acid phosphatase homologues - - - 0.0000000001357 70.0
HKD1_k127_5155795_0 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate K00108 - 1.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007476 437.0
HKD1_k127_5155795_1 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005703 371.0
HKD1_k127_5155795_2 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 289.0
HKD1_k127_5155795_3 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000141 220.0
HKD1_k127_5155795_4 SnoaL-like domain K06893 - - 0.000000000000000000000000000000000000000009226 157.0
HKD1_k127_5155795_6 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000007351 92.0
HKD1_k127_5210459_0 Glycogen debranching enzyme - - - 0.0 1578.0
HKD1_k127_5210459_1 belongs to the aldehyde dehydrogenase family K09472,K12254 - 1.2.1.54,1.2.1.99 1.239e-208 661.0
HKD1_k127_5210459_10 PFAM Rieske 2Fe-2S domain protein K18068 - 1.14.12.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 493.0
HKD1_k127_5210459_11 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002333 491.0
HKD1_k127_5210459_12 FAD dependent oxidoreductase K09471 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 475.0
HKD1_k127_5210459_13 Required for the activity of the bacterial periplasmic transport system of putrescine K02055,K11069,K11073 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 438.0
HKD1_k127_5210459_14 aminotransferase K14287 - 2.6.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 428.0
HKD1_k127_5210459_15 XdhC Rossmann domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 383.0
HKD1_k127_5210459_16 PFAM binding-protein-dependent transport systems inner membrane component K11075 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 364.0
HKD1_k127_5210459_17 Binding-protein-dependent transport system inner membrane component K11070,K11074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006447 334.0
HKD1_k127_5210459_18 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 314.0
HKD1_k127_5210459_19 PFAM Cys Met metabolism K01739,K01761 - 2.5.1.48,4.4.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000009371 264.0
HKD1_k127_5210459_2 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA K12297 - 2.1.1.173,2.1.1.264 1.29e-199 653.0
HKD1_k127_5210459_20 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000002088 222.0
HKD1_k127_5210459_21 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.0000000000000000000000000000000000000000000000000000004966 206.0
HKD1_k127_5210459_22 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000003319 176.0
HKD1_k127_5210459_23 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000009841 112.0
HKD1_k127_5210459_24 - - - - 0.00000000000000000000001327 106.0
HKD1_k127_5210459_25 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000004459 90.0
HKD1_k127_5210459_26 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone - - - 0.0000000000003259 71.0
HKD1_k127_5210459_27 alpha amylase, catalytic region - - - 0.0000000000004171 72.0
HKD1_k127_5210459_28 Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria - - - 0.0000000002944 65.0
HKD1_k127_5210459_3 Glutamine synthetase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000945 607.0
HKD1_k127_5210459_4 Glucose / Sorbosone dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004821 604.0
HKD1_k127_5210459_5 Tannase and feruloyl esterase K21105 - 3.1.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005254 591.0
HKD1_k127_5210459_6 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 570.0
HKD1_k127_5210459_7 COG0626 Cystathionine beta-lyases cystathionine gamma-synthases K01739,K01761 - 2.5.1.48,4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 566.0
HKD1_k127_5210459_8 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 504.0
HKD1_k127_5210459_9 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 502.0
HKD1_k127_5285615_0 glutamate synthase K00284 - 1.4.7.1 0.0 2516.0
HKD1_k127_5285615_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1177.0
HKD1_k127_5285615_10 cytochrome c oxidase (Subunit II) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 552.0
HKD1_k127_5285615_11 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 460.0
HKD1_k127_5285615_12 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 454.0
HKD1_k127_5285615_13 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 452.0
HKD1_k127_5285615_14 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000428 452.0
HKD1_k127_5285615_15 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 417.0
HKD1_k127_5285615_16 Arginosuccinate synthase K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009834 409.0
HKD1_k127_5285615_17 Exodeoxyribonuclease III K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004847 376.0
HKD1_k127_5285615_18 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005818 382.0
HKD1_k127_5285615_19 Glycosyltransferase Family 4 K00786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 379.0
HKD1_k127_5285615_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 2.359e-299 926.0
HKD1_k127_5285615_20 Rieske 2Fe-2S - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 370.0
HKD1_k127_5285615_21 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 398.0
HKD1_k127_5285615_22 of the major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 377.0
HKD1_k127_5285615_23 Bb3-type cytochrome oxidase subunit IV K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003982 347.0
HKD1_k127_5285615_24 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 363.0
HKD1_k127_5285615_25 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004592 341.0
HKD1_k127_5285615_26 Transport permease protein K01992 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003893 331.0
HKD1_k127_5285615_27 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006383 348.0
HKD1_k127_5285615_28 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 337.0
HKD1_k127_5285615_29 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 323.0
HKD1_k127_5285615_3 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K15022 - 1.17.1.10 5.034e-287 894.0
HKD1_k127_5285615_30 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 316.0
HKD1_k127_5285615_31 transport protein CorA K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 309.0
HKD1_k127_5285615_32 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 316.0
HKD1_k127_5285615_33 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 302.0
HKD1_k127_5285615_34 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 300.0
HKD1_k127_5285615_35 6-phosphogluconate dehydrogenase, NAD-binding K00020,K00042 - 1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 298.0
HKD1_k127_5285615_36 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 310.0
HKD1_k127_5285615_37 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 303.0
HKD1_k127_5285615_38 membrane K07278 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005871 309.0
HKD1_k127_5285615_39 Major facilitator superfamily K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 312.0
HKD1_k127_5285615_4 TIGRFAM glutamate synthases, NADH NADPH, small subunit K00266 - 1.4.1.13,1.4.1.14 3.229e-257 799.0
HKD1_k127_5285615_40 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003038 292.0
HKD1_k127_5285615_41 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 286.0
HKD1_k127_5285615_42 alpha/beta hydrolase fold K07019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 290.0
HKD1_k127_5285615_43 PFAM Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004777 292.0
HKD1_k127_5285615_44 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003171 291.0
HKD1_k127_5285615_45 TIGRFAM Cell division ATP-binding protein FtsE K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002612 279.0
HKD1_k127_5285615_46 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000003806 265.0
HKD1_k127_5285615_47 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000292 269.0
HKD1_k127_5285615_48 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000003842 269.0
HKD1_k127_5285615_49 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000004493 274.0
HKD1_k127_5285615_5 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 1.803e-250 786.0
HKD1_k127_5285615_50 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000004919 266.0
HKD1_k127_5285615_51 NADH pyrophosphatase zinc ribbon domain K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000001181 258.0
HKD1_k127_5285615_52 Belongs to the ATCase OTCase family K09065,K13043 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000001474 262.0
HKD1_k127_5285615_53 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001851 252.0
HKD1_k127_5285615_54 Hexosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002676 253.0
HKD1_k127_5285615_55 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000008006 250.0
HKD1_k127_5285615_56 Short repeat of unknown function (DUF308) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002196 240.0
HKD1_k127_5285615_57 Response regulator of the LytR AlgR family K08083 - - 0.0000000000000000000000000000000000000000000000000000000000000000001145 247.0
HKD1_k127_5285615_58 cell septum assembly - - - 0.000000000000000000000000000000000000000000000000000000000000000009228 247.0
HKD1_k127_5285615_59 Part of the ABC transporter FtsEX involved in cellular division K09811 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032153,GO:0044425,GO:0044464,GO:0051301,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000001102 244.0
HKD1_k127_5285615_6 Ammonium transporter K03320 - - 2.431e-231 726.0
HKD1_k127_5285615_60 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000001353 216.0
HKD1_k127_5285615_61 Thioesterase - - - 0.0000000000000000000000000000000000000000000000000000000001195 213.0
HKD1_k127_5285615_62 - - - - 0.0000000000000000000000000000000000000000000000000000000006345 206.0
HKD1_k127_5285615_63 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000006774 213.0
HKD1_k127_5285615_64 endonuclease III K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000006245 208.0
HKD1_k127_5285615_65 carboxymethylenebutenolidase activity K01061,K06889 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000002014 213.0
HKD1_k127_5285615_66 Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle K08316 - 2.1.1.171 0.00000000000000000000000000000000000000000000000000001162 195.0
HKD1_k127_5285615_67 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145,K05829 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000239 209.0
HKD1_k127_5285615_68 Bacterial protein of unknown function (DUF924) - - - 0.000000000000000000000000000000000000000000000000004903 188.0
HKD1_k127_5285615_69 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000005676 190.0
HKD1_k127_5285615_7 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 1.275e-200 644.0
HKD1_k127_5285615_70 PFAM Major Facilitator Superfamily K08218 - - 0.00000000000000000000000000000000000000000000000002372 195.0
HKD1_k127_5285615_71 Protein of unknown function (DUF1318) - - - 0.00000000000000000000000000000000000000000000000002582 190.0
HKD1_k127_5285615_72 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000003678 183.0
HKD1_k127_5285615_73 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000002498 189.0
HKD1_k127_5285615_74 PFAM phosphoesterase PA-phosphatase related K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000558 172.0
HKD1_k127_5285615_75 cytochrome - - - 0.0000000000000000000000000000000000000000006107 174.0
HKD1_k127_5285615_76 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000011 170.0
HKD1_k127_5285615_77 glycosyl - - - 0.000000000000000000000000000000000000000003457 169.0
HKD1_k127_5285615_78 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000154 158.0
HKD1_k127_5285615_79 glycosyl transferase, family 39 - - - 0.000000000000000000000000000000000000004633 164.0
HKD1_k127_5285615_8 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 2.66e-196 626.0
HKD1_k127_5285615_80 Protein of unknown function, DUF484 K09921 - - 0.000000000000000000000000000000000000006607 154.0
HKD1_k127_5285615_81 Prokaryotic Cytochrome C oxidase subunit IV - - - 0.000000000000000000000000000000000001102 149.0
HKD1_k127_5285615_82 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000002259 160.0
HKD1_k127_5285615_83 membrane - - - 0.0000000000000000000000000000000001617 145.0
HKD1_k127_5285615_84 Thiol disulfide interchange protein K03673 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000000000000000000000000004935 146.0
HKD1_k127_5285615_85 Ribosomal L28 family K02902 - - 0.00000000000000000000000000003608 121.0
HKD1_k127_5285615_86 Cupin domain - - - 0.00000000000000000000000000009705 123.0
HKD1_k127_5285615_87 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000002167 116.0
HKD1_k127_5285615_88 Regulates arginine biosynthesis genes K03402 - - 0.0000000000000000000000004215 110.0
HKD1_k127_5285615_89 at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA) K04752 - - 0.000000000000000000000002556 110.0
HKD1_k127_5285615_9 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 584.0
HKD1_k127_5285615_90 there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc K02913 - - 0.000000000000000001951 87.0
HKD1_k127_5285615_91 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.00000000000000003622 87.0
HKD1_k127_5285615_92 OmpA-like transmembrane domain - - - 0.00000000000001998 80.0
HKD1_k127_5285615_93 SCP-2 sterol transfer family K03690 - - 0.0000000000005827 77.0
HKD1_k127_5285615_94 Domain of unknown function (DUF4124) - - - 0.0000000000008975 77.0
HKD1_k127_5285615_95 Protein of unknown function (DUF3617) - - - 0.00000000001076 70.0
HKD1_k127_5285615_96 - - - - 0.00000000002379 74.0
HKD1_k127_5285615_97 Membrane fusogenic activity K09806 - - 0.0000002283 63.0
HKD1_k127_5285615_98 COG1664 Integral membrane protein CcmA involved in cell shape determination - - - 0.000001052 57.0
HKD1_k127_5285615_99 lyase activity - - - 0.00005558 55.0
HKD1_k127_5304447_0 Serine dehydratase beta chain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 462.0
HKD1_k127_5304447_1 PFAM Bacterial regulatory helix-turn-helix proteins, AraC family - - - 0.000000000000000000000000000000000000000000000000000000000121 217.0
HKD1_k127_5304447_2 VIT family - - - 0.000000000000000000000000000000000000001599 155.0
HKD1_k127_5469254_0 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K05712 - 1.14.13.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 352.0
HKD1_k127_5469254_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002376 270.0
HKD1_k127_5469254_2 - - - - 0.00000000000000000001177 102.0
HKD1_k127_5469254_3 Alpha beta hydrolase - - - 0.0000000000000000001472 102.0
HKD1_k127_559475_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 2.138e-202 639.0
HKD1_k127_559475_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 524.0
HKD1_k127_5727615_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 330.0
HKD1_k127_5727615_1 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009178 291.0
HKD1_k127_5727615_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000000493 242.0
HKD1_k127_5727615_3 SecE/Sec61-gamma subunits of protein translocation complex K03073 - - 0.000000000000000000000007712 106.0
HKD1_k127_5727615_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000002212 81.0
HKD1_k127_5727615_5 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.00000002262 55.0
HKD1_k127_6083116_0 secondary active sulfate transmembrane transporter activity K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004473 546.0
HKD1_k127_6083116_1 Possible lysine decarboxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 304.0
HKD1_k127_6083116_2 Acetolactate synthase, large subunit K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006027 282.0
HKD1_k127_6130821_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1367.0
HKD1_k127_6130821_1 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1307.0
HKD1_k127_6130821_10 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.459e-256 804.0
HKD1_k127_6130821_100 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 357.0
HKD1_k127_6130821_101 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005366 339.0
HKD1_k127_6130821_102 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 349.0
HKD1_k127_6130821_103 Phosphate transport system permease K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007958 340.0
HKD1_k127_6130821_104 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 339.0
HKD1_k127_6130821_105 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 338.0
HKD1_k127_6130821_106 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 336.0
HKD1_k127_6130821_107 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 336.0
HKD1_k127_6130821_108 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 335.0
HKD1_k127_6130821_109 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 336.0
HKD1_k127_6130821_11 Belongs to the IlvD Edd family K01687 - 4.2.1.9 5.148e-249 781.0
HKD1_k127_6130821_110 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 334.0
HKD1_k127_6130821_111 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 342.0
HKD1_k127_6130821_112 Preprotein translocase subunit TatD K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002554 324.0
HKD1_k127_6130821_113 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007974 331.0
HKD1_k127_6130821_114 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 323.0
HKD1_k127_6130821_115 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 316.0
HKD1_k127_6130821_116 sulfate ABC transporter K02046 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009336 312.0
HKD1_k127_6130821_117 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004502 311.0
HKD1_k127_6130821_118 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006452 308.0
HKD1_k127_6130821_119 phosphate regulon transcriptional regulatory protein PhoB K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 303.0
HKD1_k127_6130821_12 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 3.452e-244 764.0
HKD1_k127_6130821_120 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 301.0
HKD1_k127_6130821_121 Periplasmic binding protein LacI transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 319.0
HKD1_k127_6130821_122 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07660 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006587 306.0
HKD1_k127_6130821_123 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008856 313.0
HKD1_k127_6130821_124 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009506 314.0
HKD1_k127_6130821_125 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 308.0
HKD1_k127_6130821_126 reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 302.0
HKD1_k127_6130821_127 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 296.0
HKD1_k127_6130821_128 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 292.0
HKD1_k127_6130821_129 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 305.0
HKD1_k127_6130821_13 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 2.095e-240 755.0
HKD1_k127_6130821_130 Methionine synthase B12-binding module cap domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 292.0
HKD1_k127_6130821_131 PFAM MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 289.0
HKD1_k127_6130821_132 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009621 288.0
HKD1_k127_6130821_133 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005225 300.0
HKD1_k127_6130821_134 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002994 280.0
HKD1_k127_6130821_135 ATP ADP translocase K03301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004426 290.0
HKD1_k127_6130821_136 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003515 296.0
HKD1_k127_6130821_137 Belongs to the bacterial glucokinase family K00845 GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051156,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003009 281.0
HKD1_k127_6130821_138 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003741 280.0
HKD1_k127_6130821_139 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008231 279.0
HKD1_k127_6130821_14 Aminomethyltransferase folate-binding domain K15066 - 2.1.1.341 3.146e-231 723.0
HKD1_k127_6130821_140 PFAM ErfK YbiS YcfS YnhG family protein K16291 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001822 282.0
HKD1_k127_6130821_141 ABC 3 transport family K02075 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002016 273.0
HKD1_k127_6130821_142 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003333 269.0
HKD1_k127_6130821_143 MazG nucleotide pyrophosphohydrolase domain K04765 - 3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000001032 274.0
HKD1_k127_6130821_144 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007748 287.0
HKD1_k127_6130821_145 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001107 264.0
HKD1_k127_6130821_146 Histidine kinase K07637 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000004181 266.0
HKD1_k127_6130821_147 Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis K03683 GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000131 270.0
HKD1_k127_6130821_148 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000000000000000001068 252.0
HKD1_k127_6130821_149 MOSC N-terminal beta barrel domain K07140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003844 257.0
HKD1_k127_6130821_15 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 6.151e-225 717.0
HKD1_k127_6130821_150 Belongs to the AB hydrolase superfamily. MetX family K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000004386 254.0
HKD1_k127_6130821_151 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000000000000000000000000000000000002855 243.0
HKD1_k127_6130821_152 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002652 244.0
HKD1_k127_6130821_153 Two component transcriptional regulator, winged helix family - - - 0.00000000000000000000000000000000000000000000000000000000000000000004689 241.0
HKD1_k127_6130821_154 Belongs to the WrbA family K03809 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000004703 237.0
HKD1_k127_6130821_155 TIGRFAM Phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000007445 260.0
HKD1_k127_6130821_156 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000001318 231.0
HKD1_k127_6130821_157 Histidine biosynthesis bifunctional protein HisIE K11755 GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000000000000000000000002094 235.0
HKD1_k127_6130821_158 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000001459 239.0
HKD1_k127_6130821_159 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000003862 229.0
HKD1_k127_6130821_16 Protein tyrosine kinase - - - 6.678e-222 713.0
HKD1_k127_6130821_160 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0033554,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0050896,GO:0051716,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000001148 229.0
HKD1_k127_6130821_161 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000005266 235.0
HKD1_k127_6130821_162 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000007226 235.0
HKD1_k127_6130821_163 Forkhead associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000002727 228.0
HKD1_k127_6130821_164 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000002345 223.0
HKD1_k127_6130821_165 Peroxiredoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000001071 218.0
HKD1_k127_6130821_166 Urate oxidase N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000253 216.0
HKD1_k127_6130821_167 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000001582 220.0
HKD1_k127_6130821_168 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 0.00000000000000000000000000000000000000000000000000000000009065 211.0
HKD1_k127_6130821_169 membrane - - - 0.000000000000000000000000000000000000000000000000000000000304 209.0
HKD1_k127_6130821_17 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 2.015e-209 664.0
HKD1_k127_6130821_170 PFAM Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000003768 210.0
HKD1_k127_6130821_171 PFAM Aminotransferase, class IV K02619 - 4.1.3.38 0.000000000000000000000000000000000000000000000000000000003 215.0
HKD1_k127_6130821_172 Belongs to the UPF0311 family - - - 0.000000000000000000000000000000000000000000000000000000004521 204.0
HKD1_k127_6130821_173 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000659 207.0
HKD1_k127_6130821_174 Polysaccharide biosynthesis/export protein K01991 - - 0.00000000000000000000000000000000000000000000000000000002986 206.0
HKD1_k127_6130821_175 involved in chromosome partitioning - - - 0.00000000000000000000000000000000000000000000000000000004514 207.0
HKD1_k127_6130821_176 - - - - 0.00000000000000000000000000000000000000000000000000000006443 213.0
HKD1_k127_6130821_177 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008270,GO:0008685,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016849,GO:0030145,GO:0042180,GO:0042181,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.6.1.12 0.00000000000000000000000000000000000000000000000000000006855 200.0
HKD1_k127_6130821_178 permease K07091 - - 0.000000000000000000000000000000000000000000000000000001775 205.0
HKD1_k127_6130821_179 general secretion pathway protein G K02456 - - 0.000000000000000000000000000000000000000000000000000001876 195.0
HKD1_k127_6130821_18 Enoyl-CoA hydratase/isomerase - - - 3.958e-209 676.0
HKD1_k127_6130821_180 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000000000000000000003568 196.0
HKD1_k127_6130821_181 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000001947 202.0
HKD1_k127_6130821_182 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000002462 200.0
HKD1_k127_6130821_183 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000000000000000002831 204.0
HKD1_k127_6130821_184 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.000000000000000000000000000000000000000000000000002834 192.0
HKD1_k127_6130821_185 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000002423 196.0
HKD1_k127_6130821_186 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000000000000000000000000000000004116 186.0
HKD1_k127_6130821_187 Belongs to the DnaA family. HdA subfamily K10763 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - 0.00000000000000000000000000000000000000000000000006037 186.0
HKD1_k127_6130821_188 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000001229 184.0
HKD1_k127_6130821_189 Part of a membrane complex involved in electron transport K03616 - - 0.000000000000000000000000000000000000000000000001961 184.0
HKD1_k127_6130821_19 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 1.864e-205 660.0
HKD1_k127_6130821_190 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.00000000000000000000000000000000000000000000005285 175.0
HKD1_k127_6130821_191 Permease YjgP YjgQ K11720 - - 0.00000000000000000000000000000000000000000000005818 187.0
HKD1_k127_6130821_192 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000078 184.0
HKD1_k127_6130821_193 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000001493 175.0
HKD1_k127_6130821_194 PilZ domain K02676 - - 0.000000000000000000000000000000000000000000000744 173.0
HKD1_k127_6130821_195 TonB dependent biopolymer transporter integral cytoplasmic membrane subunit, working with ExbB K03559 - - 0.000000000000000000000000000000000000000000001425 169.0
HKD1_k127_6130821_196 - - - - 0.00000000000000000000000000000000000000000008207 177.0
HKD1_k127_6130821_197 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.0000000000000000000000000000000000000000001296 171.0
HKD1_k127_6130821_198 NUDIX domain - - - 0.0000000000000000000000000000000000000000007028 165.0
HKD1_k127_6130821_199 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.000000000000000000000000000000000000000006886 156.0
HKD1_k127_6130821_2 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1210.0
HKD1_k127_6130821_20 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 1.125e-203 661.0
HKD1_k127_6130821_200 Type II secretion system (T2SS), protein K K02460 - - 0.00000000000000000000000000000000000000001197 175.0
HKD1_k127_6130821_201 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.00000000000000000000000000000000000000007525 164.0
HKD1_k127_6130821_202 Pili and flagellar-assembly chaperone, PapD N-terminal domain K07346 - - 0.00000000000000000000000000000000000000008179 169.0
HKD1_k127_6130821_203 PFAM Peptidase M22, glycoprotease K14742 - - 0.0000000000000000000000000000000000000002976 159.0
HKD1_k127_6130821_204 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000000000000000000000000000000004026 165.0
HKD1_k127_6130821_205 - - - - 0.0000000000000000000000000000000000000004081 166.0
HKD1_k127_6130821_206 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K13053 - - 0.000000000000000000000000000000000000001962 155.0
HKD1_k127_6130821_207 DNA polymerase III, delta' K02341 - 2.7.7.7 0.000000000000000000000000000000000000004028 158.0
HKD1_k127_6130821_208 PFAM CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.0000000000000000000000000000000000002225 149.0
HKD1_k127_6130821_209 WLM domain K07043 - - 0.000000000000000000000000000000000001095 148.0
HKD1_k127_6130821_21 AMP-binding enzyme K12508 - 6.2.1.34 2.611e-201 649.0
HKD1_k127_6130821_210 - - - - 0.00000000000000000000000000000000009584 138.0
HKD1_k127_6130821_211 Biopolymer transport protein ExbD/TolR K03559 - - 0.0000000000000000000000000000000004443 136.0
HKD1_k127_6130821_212 Type II secretion system (T2SS), protein J - - - 0.00000000000000000000000000000004859 134.0
HKD1_k127_6130821_213 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02461 - - 0.00000000000000000000000000000005579 139.0
HKD1_k127_6130821_215 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000000000000000000000000000002037 121.0
HKD1_k127_6130821_216 Universal stress protein K14055 GO:0000302,GO:0001539,GO:0006928,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0033554,GO:0034599,GO:0034614,GO:0034644,GO:0035690,GO:0040011,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044764,GO:0046677,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071478,GO:0071482,GO:0071973,GO:0097237,GO:0097588,GO:0104004,GO:1901700,GO:1901701 - 0.000000000000000000000000000002161 133.0
HKD1_k127_6130821_217 SMR domain protein - - - 0.000000000000000000000000000008555 126.0
HKD1_k127_6130821_218 Domain of unknown function (DUF1841) - - - 0.00000000000000000000000000002666 131.0
HKD1_k127_6130821_219 PFAM Cytochrome C - - - 0.00000000000000000000000000004835 124.0
HKD1_k127_6130821_22 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582 - 3.1.11.5 1.011e-200 667.0
HKD1_k127_6130821_220 Secreted protein - - - 0.00000000000000000000000000005459 123.0
HKD1_k127_6130821_221 Valyl tRNA synthetase tRNA binding arm K01873 - 6.1.1.9 0.0000000000000000000000000001314 116.0
HKD1_k127_6130821_222 methionine synthase K00548 - 2.1.1.13 0.0000000000000000000000000007673 122.0
HKD1_k127_6130821_223 proteolysis - - - 0.0000000000000000000000000009231 120.0
HKD1_k127_6130821_224 Belongs to the MtfA family K09933 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0006807,GO:0008134,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0043170,GO:0043433,GO:0044092,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000001049 123.0
HKD1_k127_6130821_225 Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000000001414 113.0
HKD1_k127_6130821_226 Polysaccharide deacetylase - - - 0.0000000000000000000000005535 117.0
HKD1_k127_6130821_227 Trp repressor protein - - - 0.0000000000000000000000006734 107.0
HKD1_k127_6130821_228 DNA polymerase III, chi subunit K02339 - 2.7.7.7 0.000000000000000000000005416 109.0
HKD1_k127_6130821_229 haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000001767 108.0
HKD1_k127_6130821_23 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 1.242e-195 625.0
HKD1_k127_6130821_230 Outer membrane protein (OmpH-like) K06142 - - 0.000000000000000000001257 101.0
HKD1_k127_6130821_231 protein acetylation - - - 0.000000000000000000001994 106.0
HKD1_k127_6130821_232 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301 - 0.000000000000000000003687 97.0
HKD1_k127_6130821_233 O-Antigen ligase - - - 0.00000000000000000004807 107.0
HKD1_k127_6130821_234 - - - - 0.0000000000000000001589 88.0
HKD1_k127_6130821_235 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.0000000000000000004981 90.0
HKD1_k127_6130821_236 Type II secretion system (T2SS), protein I - - - 0.0000000000000000006446 95.0
HKD1_k127_6130821_237 Protein of unknown function (DUF498/DUF598) - - - 0.000000000000000003363 94.0
HKD1_k127_6130821_238 Copper chaperone PCu(A)C K09796 - - 0.000000000000000007002 89.0
HKD1_k127_6130821_239 Spore Coat Protein U domain - - - 0.00000000000000002417 88.0
HKD1_k127_6130821_24 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005238 614.0
HKD1_k127_6130821_240 BON domain - - - 0.00000000000000005309 83.0
HKD1_k127_6130821_241 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity - - - 0.0000000000000001016 91.0
HKD1_k127_6130821_242 Polysaccharide biosynthesis protein - - - 0.0000000000000002219 93.0
HKD1_k127_6130821_243 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02462 - - 0.000000000000001362 84.0
HKD1_k127_6130821_244 Glycosyl transferases group 1 - - - 0.000000000000001837 90.0
HKD1_k127_6130821_245 general secretion pathway protein h K02457 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.000000000000003089 84.0
HKD1_k127_6130821_246 antibiotic catabolic process K18235 - - 0.000000000000003568 90.0
HKD1_k127_6130821_247 NERD domain protein - - - 0.000000000000005216 85.0
HKD1_k127_6130821_248 Cytochrome c551 c552 K08738 - - 0.00000000000002487 87.0
HKD1_k127_6130821_249 Acetyltransferase (GNAT) domain - - - 0.00000000000009874 83.0
HKD1_k127_6130821_25 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006919 599.0
HKD1_k127_6130821_250 regulator of chromosome condensation, RCC1 - - - 0.000000000000959 77.0
HKD1_k127_6130821_251 metallopeptidase activity - - - 0.00000000001374 70.0
HKD1_k127_6130821_252 Acetyltransferase (GNAT) domain - - - 0.0000000005258 71.0
HKD1_k127_6130821_253 MTH538 TIR-like domain (DUF1863) - - - 0.0000000006675 66.0
HKD1_k127_6130821_254 - - - - 0.0000000261 66.0
HKD1_k127_6130821_255 pathogenesis - - - 0.00000007262 66.0
HKD1_k127_6130821_256 Acetyltransferase (GNAT) domain - - - 0.0000001036 64.0
HKD1_k127_6130821_257 Type II secretion system (T2SS), protein N K02463 - - 0.000007605 58.0
HKD1_k127_6130821_258 PFAM type II secretion system K12511 - - 0.00001652 57.0
HKD1_k127_6130821_259 TIGRFAM TonB family protein K03832 - - 0.0002133 52.0
HKD1_k127_6130821_26 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 628.0
HKD1_k127_6130821_27 PFAM Uroporphyrinogen decarboxylase (URO-D) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000681 594.0
HKD1_k127_6130821_28 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003659 606.0
HKD1_k127_6130821_29 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 595.0
HKD1_k127_6130821_3 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1161.0
HKD1_k127_6130821_30 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005377 584.0
HKD1_k127_6130821_31 Domain of unknown function (DUF4445) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 582.0
HKD1_k127_6130821_32 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00646,K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 569.0
HKD1_k127_6130821_33 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009127 577.0
HKD1_k127_6130821_34 Helicase K03722 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 569.0
HKD1_k127_6130821_35 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007409 566.0
HKD1_k127_6130821_36 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 517.0
HKD1_k127_6130821_37 PFAM Type II secretion system protein E - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 516.0
HKD1_k127_6130821_38 cystathionine K01739 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006448 504.0
HKD1_k127_6130821_39 Succinyldiaminopimelate K14261,K14267 - 2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 507.0
HKD1_k127_6130821_4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1121.0
HKD1_k127_6130821_40 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007503 496.0
HKD1_k127_6130821_41 acetoacetate metabolism regulatory protein AtoC K07714 K07715 GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 500.0
HKD1_k127_6130821_42 Amidase K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004353 497.0
HKD1_k127_6130821_43 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 486.0
HKD1_k127_6130821_44 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008164 494.0
HKD1_k127_6130821_45 Phosphoribosylformylglycinamidine cyclo-ligase K01933 GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 482.0
HKD1_k127_6130821_46 PBP superfamily domain K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 475.0
HKD1_k127_6130821_47 PFAM amidohydrolase 2 K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 471.0
HKD1_k127_6130821_48 aminotransferase K14260 - 2.6.1.2,2.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006929 471.0
HKD1_k127_6130821_49 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 460.0
HKD1_k127_6130821_5 Belongs to the Orn Lys Arg decarboxylase class-II family K00928,K12526 - 2.7.2.4,4.1.1.20 5.025e-303 953.0
HKD1_k127_6130821_50 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784,K12448 - 5.1.3.2,5.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009968 457.0
HKD1_k127_6130821_51 PFAM Type II secretion system protein E K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 450.0
HKD1_k127_6130821_52 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000734 446.0
HKD1_k127_6130821_53 Sulfate ABC transporter, periplasmic sulfate-binding protein K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 445.0
HKD1_k127_6130821_55 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 454.0
HKD1_k127_6130821_56 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007255 455.0
HKD1_k127_6130821_57 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000225 443.0
HKD1_k127_6130821_58 COG3202 ATP ADP translocase K03301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 443.0
HKD1_k127_6130821_59 Major facilitator superfamily K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007561 449.0
HKD1_k127_6130821_6 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 3.491e-286 905.0
HKD1_k127_6130821_60 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 435.0
HKD1_k127_6130821_61 Threonine synthase K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002941 444.0
HKD1_k127_6130821_62 Anthranilate synthase component I K01657,K01665 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 441.0
HKD1_k127_6130821_63 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00382,K00627 - 1.8.1.4,2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 439.0
HKD1_k127_6130821_64 Sugar-transfer associated ATP-grasp - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 433.0
HKD1_k127_6130821_65 Belongs to the peptidase M17 family K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008217 437.0
HKD1_k127_6130821_66 phosphate-selective porin O and P - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007987 432.0
HKD1_k127_6130821_67 Outer membrane usher protein K07347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000415 444.0
HKD1_k127_6130821_68 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 419.0
HKD1_k127_6130821_69 Belongs to the DegT DnrJ EryC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 413.0
HKD1_k127_6130821_7 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 6.112e-275 880.0
HKD1_k127_6130821_70 ATPase activity K02045 - 3.6.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 419.0
HKD1_k127_6130821_71 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004577 402.0
HKD1_k127_6130821_72 COG2148 Sugar transferases involved in lipopolysaccharide synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 411.0
HKD1_k127_6130821_73 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004191 406.0
HKD1_k127_6130821_74 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004218 402.0
HKD1_k127_6130821_75 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002449 394.0
HKD1_k127_6130821_76 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006135 409.0
HKD1_k127_6130821_77 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 393.0
HKD1_k127_6130821_78 belongs to the histidinol- phosphatase family K01089,K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009016 405.0
HKD1_k127_6130821_79 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 GO:0002097,GO:0002098,GO:0002143,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009967 394.0
HKD1_k127_6130821_8 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 4.316e-268 836.0
HKD1_k127_6130821_80 His Kinase A (phosphoacceptor) domain K07641,K10819 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004047 402.0
HKD1_k127_6130821_81 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004846 385.0
HKD1_k127_6130821_82 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 381.0
HKD1_k127_6130821_83 Phosphate-selective porin O and P - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 383.0
HKD1_k127_6130821_84 sulfate transport system, permease K02047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000883 379.0
HKD1_k127_6130821_85 PFAM Transglutaminase-like K22452 - 2.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 391.0
HKD1_k127_6130821_86 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 372.0
HKD1_k127_6130821_87 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007074 373.0
HKD1_k127_6130821_88 Subtilase family K14645 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 389.0
HKD1_k127_6130821_89 NmrA family K19267 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002064 361.0
HKD1_k127_6130821_9 homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 1.867e-256 815.0
HKD1_k127_6130821_90 Histidine kinase K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 371.0
HKD1_k127_6130821_91 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 355.0
HKD1_k127_6130821_92 Belongs to the bacterial solute-binding protein 9 family K02077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 363.0
HKD1_k127_6130821_93 PFAM Phosphate-selective porin O K07221 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 374.0
HKD1_k127_6130821_94 PFAM fumarylacetoacetate (FAA) hydrolase K01826 - 5.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004593 357.0
HKD1_k127_6130821_95 associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 356.0
HKD1_k127_6130821_96 zinc metalloprotease K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 364.0
HKD1_k127_6130821_97 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005951 356.0
HKD1_k127_6130821_98 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002506 348.0
HKD1_k127_6130821_99 Polysaccharide chain length determinant protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 359.0
HKD1_k127_6156823_0 UPF0313 protein - - - 0.0 1019.0
HKD1_k127_6156823_1 Insulinase (Peptidase family M16) K07263 - - 1.306e-311 1004.0
HKD1_k127_6156823_10 HlyD family secretion protein K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004754 350.0
HKD1_k127_6156823_11 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 344.0
HKD1_k127_6156823_12 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006199 334.0
HKD1_k127_6156823_13 Peptidase C26 K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005538 289.0
HKD1_k127_6156823_14 aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004032 295.0
HKD1_k127_6156823_15 ABC transporter, periplasmic molybdate-binding protein K02020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001858 269.0
HKD1_k127_6156823_16 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001383 279.0
HKD1_k127_6156823_17 Bacterial extracellular solute-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004284 269.0
HKD1_k127_6156823_18 Psort location CytoplasmicMembrane, score 9.49 K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002141 254.0
HKD1_k127_6156823_19 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000004424 223.0
HKD1_k127_6156823_2 ATP-dependent helicase K03579 - 3.6.4.13 6.474e-249 805.0
HKD1_k127_6156823_20 Uncharacterised conserved protein (DUF2156) K07027,K14205 - 2.3.2.3 0.0000000000000000000000000000000000000000000000000002055 199.0
HKD1_k127_6156823_21 Bacterial virulence protein (VirJ) - - - 0.000000000000000000000000000000000000000000000000001315 197.0
HKD1_k127_6156823_22 low molecular weight K01104 - 3.1.3.48 0.00000000000000000000000000000000000000000000419 171.0
HKD1_k127_6156823_23 - - - - 0.000000000000000000000000000004506 132.0
HKD1_k127_6156823_24 Binding-protein-dependent transport system inner membrane component K02018 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000000000008562 90.0
HKD1_k127_6156823_25 membrane - - - 0.0000000000000000001889 96.0
HKD1_k127_6156823_3 Uncharacterised conserved protein (DUF2156) K07027,K14205 - 2.3.2.3 8.767e-246 785.0
HKD1_k127_6156823_4 FtsX-like permease family K02004 - - 1.533e-243 778.0
HKD1_k127_6156823_5 Protein of unknown function (DUF1343) - - - 1.109e-220 690.0
HKD1_k127_6156823_6 cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 505.0
HKD1_k127_6156823_7 PFAM Phosphate-selective porin O and P K07221 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006363 379.0
HKD1_k127_6156823_8 Peptidase dimerisation domain K01439,K13049 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007867 370.0
HKD1_k127_6156823_9 COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009949 359.0
HKD1_k127_6157515_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 0.0 1245.0
HKD1_k127_6157515_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 3.331e-316 980.0
HKD1_k127_6157515_10 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005111 525.0
HKD1_k127_6157515_11 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 508.0
HKD1_k127_6157515_12 Methionine synthase K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 433.0
HKD1_k127_6157515_13 PFAM Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008058 407.0
HKD1_k127_6157515_14 6-phosphogluconate dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006816 381.0
HKD1_k127_6157515_15 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 387.0
HKD1_k127_6157515_16 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 374.0
HKD1_k127_6157515_17 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008495 360.0
HKD1_k127_6157515_18 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004092 358.0
HKD1_k127_6157515_19 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 297.0
HKD1_k127_6157515_2 Required for chromosome condensation and partitioning K03529 - - 5.964e-304 971.0
HKD1_k127_6157515_20 Belongs to the SUA5 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 287.0
HKD1_k127_6157515_21 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 GO:0000166,GO:0002097,GO:0003674,GO:0005488,GO:0005524,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006717 273.0
HKD1_k127_6157515_22 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000004194 265.0
HKD1_k127_6157515_23 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000000004109 245.0
HKD1_k127_6157515_24 HAD-superfamily hydrolase, subfamily IA, variant 1 K22292 - 3.1.3.105 0.00000000000000000000000000000000000000000000000000000000000000000001772 251.0
HKD1_k127_6157515_25 reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000004289 232.0
HKD1_k127_6157515_26 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000000000000000001107 226.0
HKD1_k127_6157515_27 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000000000000000000005775 209.0
HKD1_k127_6157515_28 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000002582 213.0
HKD1_k127_6157515_29 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression K06204 - - 0.0000000000000000000000000000000000000000000002727 177.0
HKD1_k127_6157515_3 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 2.307e-280 885.0
HKD1_k127_6157515_30 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000001642 169.0
HKD1_k127_6157515_31 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.000000000000000000000000000000000000000001152 157.0
HKD1_k127_6157515_32 6-phosphogluconolactonase activity - - - 0.000000000000000000000000000000000000000002654 172.0
HKD1_k127_6157515_33 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000004384 157.0
HKD1_k127_6157515_34 probably involved in intracellular septation K06190 - - 0.00000000000000000000000000000000000006948 150.0
HKD1_k127_6157515_35 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000002342 119.0
HKD1_k127_6157515_36 TIGRFAM Polyhydroxyalkanoate synthesis repressor PhaR - - - 0.0000000000000000000000000003506 120.0
HKD1_k127_6157515_37 Belongs to the BolA IbaG family K05527,K22066 - - 0.0000000000000000001513 96.0
HKD1_k127_6157515_38 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000002056 93.0
HKD1_k127_6157515_39 competence protein ComEA K02237 - - 0.0000000000000000003035 96.0
HKD1_k127_6157515_4 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 1.622e-266 829.0
HKD1_k127_6157515_40 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins K03528 - - 0.00000006037 64.0
HKD1_k127_6157515_41 Phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.000001261 59.0
HKD1_k127_6157515_5 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 5.158e-239 759.0
HKD1_k127_6157515_6 Participates in both transcription termination and antitermination K02600 - - 5.12e-210 664.0
HKD1_k127_6157515_7 Aldehyde dehydrogenase family K00141 - 1.2.1.28 2.352e-202 644.0
HKD1_k127_6157515_8 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 599.0
HKD1_k127_6157515_9 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 532.0
HKD1_k127_6178032_0 AcrB/AcrD/AcrF family - - - 0.0 1313.0
HKD1_k127_6178032_1 Dehydrogenase E1 component K00164 - 1.2.4.2 0.0 1092.0
HKD1_k127_6178032_10 Sugar (and other) transporter - - - 1.418e-203 647.0
HKD1_k127_6178032_11 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147 - - 6.663e-200 640.0
HKD1_k127_6178032_12 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840,K15778 - 5.4.2.2,5.4.2.8 5.533e-197 627.0
HKD1_k127_6178032_13 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002733 604.0
HKD1_k127_6178032_14 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 602.0
HKD1_k127_6178032_15 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 601.0
HKD1_k127_6178032_16 C-terminal AAA-associated domain K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003482 594.0
HKD1_k127_6178032_17 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 578.0
HKD1_k127_6178032_18 E3 component of 2-oxoglutarate dehydrogenase complex K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 559.0
HKD1_k127_6178032_19 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 568.0
HKD1_k127_6178032_2 NADH:flavin oxidoreductase / NADH oxidase family K00317 - 1.5.8.1,1.5.8.2 1.407e-263 827.0
HKD1_k127_6178032_20 PFAM AMP-dependent synthetase and ligase K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 551.0
HKD1_k127_6178032_21 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 502.0
HKD1_k127_6178032_22 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 505.0
HKD1_k127_6178032_23 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 454.0
HKD1_k127_6178032_24 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 472.0
HKD1_k127_6178032_25 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003768 448.0
HKD1_k127_6178032_26 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00596,K00836,K15372 - 2.6.1.55,2.6.1.76,4.1.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 440.0
HKD1_k127_6178032_27 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008493 430.0
HKD1_k127_6178032_28 Involved in the TonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 407.0
HKD1_k127_6178032_29 PFAM Cytochrome P450 K14338 - 1.14.14.1,1.6.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 403.0
HKD1_k127_6178032_3 Amidohydrolase family - - - 6.774e-250 790.0
HKD1_k127_6178032_30 efflux protein, MATE family K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006882 413.0
HKD1_k127_6178032_31 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 369.0
HKD1_k127_6178032_32 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005289 355.0
HKD1_k127_6178032_33 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 359.0
HKD1_k127_6178032_34 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008534 352.0
HKD1_k127_6178032_35 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 338.0
HKD1_k127_6178032_36 Biotin-lipoyl like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005214 352.0
HKD1_k127_6178032_37 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007429 348.0
HKD1_k127_6178032_38 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009812 325.0
HKD1_k127_6178032_39 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 290.0
HKD1_k127_6178032_4 belongs to the aldehyde dehydrogenase family - - - 4.194e-248 774.0
HKD1_k127_6178032_40 COG2755 Lysophospholipase L1 and related esterases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009732 294.0
HKD1_k127_6178032_41 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000185 291.0
HKD1_k127_6178032_42 Amino acid synthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005008 272.0
HKD1_k127_6178032_43 ParB-like nuclease domain K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008017 277.0
HKD1_k127_6178032_44 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000178 271.0
HKD1_k127_6178032_45 Predicted integral membrane protein (DUF2189) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001262 257.0
HKD1_k127_6178032_46 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002791 256.0
HKD1_k127_6178032_47 COG0811 Biopolymer transport proteins K03562 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017038,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000005392 258.0
HKD1_k127_6178032_48 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000002006 247.0
HKD1_k127_6178032_49 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000005618 232.0
HKD1_k127_6178032_5 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 1.64e-210 662.0
HKD1_k127_6178032_50 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000000000000000000000000000000000000000003111 233.0
HKD1_k127_6178032_51 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000001487 221.0
HKD1_k127_6178032_52 Protein of unknown function (DUF1134) - - - 0.000000000000000000000000000000000000000000000000000000000006801 213.0
HKD1_k127_6178032_53 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000009686 218.0
HKD1_k127_6178032_54 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000513 211.0
HKD1_k127_6178032_55 Cytochrome b/b6/petB K12262 - - 0.00000000000000000000000000000000000000000000000000001947 207.0
HKD1_k127_6178032_56 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000000006926 191.0
HKD1_k127_6178032_57 Sulfatase - - - 0.00000000000000000000000000000000000000000000000001681 200.0
HKD1_k127_6178032_58 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000004588 184.0
HKD1_k127_6178032_59 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000001358 174.0
HKD1_k127_6178032_6 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.797e-208 660.0
HKD1_k127_6178032_60 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000009971 165.0
HKD1_k127_6178032_61 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.0000000000000000000000000000000000000000001127 166.0
HKD1_k127_6178032_62 2-keto-4-pentenoate hydratase K18364 - 4.2.1.132,4.2.1.80 0.00000000000000000000000000000000000000006014 162.0
HKD1_k127_6178032_63 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000009498 156.0
HKD1_k127_6178032_64 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000000000000000000000000004754 147.0
HKD1_k127_6178032_65 thioesterase K07107 - - 0.00000000000000000000000000000000003219 141.0
HKD1_k127_6178032_66 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000007182 146.0
HKD1_k127_6178032_67 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase - - - 0.0000000000000000000000000000000001058 150.0
HKD1_k127_6178032_68 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000007239 124.0
HKD1_k127_6178032_69 Domain of unknown function (DUF4184) - - - 0.0000000000000000000000001984 117.0
HKD1_k127_6178032_7 Thiamine pyrophosphate enzyme, central domain K01576 - 4.1.1.7 2.86e-206 654.0
HKD1_k127_6178032_70 Domain of unknown function (DUF4136) - - - 0.000000000000000000000009405 108.0
HKD1_k127_6178032_71 Phospholipid N-methyltransferase - - - 0.00000000000000000003994 102.0
HKD1_k127_6178032_72 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000000000000000007367 91.0
HKD1_k127_6178032_73 Belongs to the ompA family - - - 0.00000000000000002093 90.0
HKD1_k127_6178032_74 TonB C terminal K03832 - - 0.0000000000001629 81.0
HKD1_k127_6178032_75 - - - - 0.000000000001124 82.0
HKD1_k127_6178032_76 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000562 70.0
HKD1_k127_6178032_77 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000002906 65.0
HKD1_k127_6178032_78 ParE toxin of type II toxin-antitoxin system, parDE K19092 - - 0.000009607 47.0
HKD1_k127_6178032_79 Belongs to the SlyX family K03745 - - 0.0001075 47.0
HKD1_k127_6178032_8 Binding-protein-dependent transport systems inner membrane component K02050 - - 5.793e-206 655.0
HKD1_k127_6178032_81 Phage integrase family - - - 0.0002152 45.0
HKD1_k127_6178032_9 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 6.104e-206 648.0
HKD1_k127_6179674_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1179.0
HKD1_k127_6179674_1 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 1.09e-314 981.0
HKD1_k127_6179674_10 Type II secretion system K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007361 507.0
HKD1_k127_6179674_11 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007315 502.0
HKD1_k127_6179674_12 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 431.0
HKD1_k127_6179674_13 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003512 434.0
HKD1_k127_6179674_14 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 455.0
HKD1_k127_6179674_15 Arabinose 5-phosphate isomerase K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003063 423.0
HKD1_k127_6179674_16 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003898 418.0
HKD1_k127_6179674_17 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 399.0
HKD1_k127_6179674_18 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009304 361.0
HKD1_k127_6179674_19 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 363.0
HKD1_k127_6179674_2 TIGRFAM type IV-A pilus assembly ATPase PilB K02652 - - 2.621e-222 703.0
HKD1_k127_6179674_20 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006565 379.0
HKD1_k127_6179674_21 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006992 347.0
HKD1_k127_6179674_22 PFAM ABC transporter K06861 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005024 334.0
HKD1_k127_6179674_23 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005281 325.0
HKD1_k127_6179674_24 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005691 320.0
HKD1_k127_6179674_25 Belongs to the peptidase S1C family K04691,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007716 321.0
HKD1_k127_6179674_26 Displays ATPase and GTPase activities K06958 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 301.0
HKD1_k127_6179674_27 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000002684 277.0
HKD1_k127_6179674_28 Divergent 4Fe-4S mono-cluster - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000513 251.0
HKD1_k127_6179674_29 Stringent starvation protein A K03599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001189 245.0
HKD1_k127_6179674_3 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 1.526e-206 649.0
HKD1_k127_6179674_30 PFAM LppC K07121 - - 0.000000000000000000000000000000000000000000000000000000000000000001201 257.0
HKD1_k127_6179674_31 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000001442 234.0
HKD1_k127_6179674_32 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.000000000000000000000000000000000000000000000000000000000000000003645 241.0
HKD1_k127_6179674_33 cytochrome K00413 - - 0.00000000000000000000000000000000000000000000000000000000000000001305 232.0
HKD1_k127_6179674_34 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.000000000000000000000000000000000000000000000000000000002048 210.0
HKD1_k127_6179674_35 Belongs to the MraZ family K03925 - - 0.000000000000000000000000000000000000000000000000000001717 195.0
HKD1_k127_6179674_36 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.0000000000000000000000000000000000000000000000000001792 195.0
HKD1_k127_6179674_37 PFAM branched-chain amino acid transport - - - 0.0000000000000000000000000000000000000005002 150.0
HKD1_k127_6179674_38 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.000000000000000000000000000000000003116 154.0
HKD1_k127_6179674_39 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.00000000000000000000000000000000003046 146.0
HKD1_k127_6179674_4 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - 7.044e-201 631.0
HKD1_k127_6179674_40 Stringent starvation protein B K03600 - - 0.00000000000000000000000000000000004394 141.0
HKD1_k127_6179674_41 - - - - 0.0000000000000000000000000000000007235 134.0
HKD1_k127_6179674_42 Thiamine monophosphate synthase K03574 - 3.6.1.55 0.000000000000000000000000000000004024 136.0
HKD1_k127_6179674_43 Sigma 54 modulation protein K05808 - - 0.000000000000000000000000000000008655 131.0
HKD1_k127_6179674_44 Translation initiation factor SUI1 K03113 - - 0.000000000000000000000000000001276 141.0
HKD1_k127_6179674_45 nucleic acid phosphodiester bond hydrolysis K07460 - - 0.0000000000000000000000000001711 119.0
HKD1_k127_6179674_46 Belongs to the BolA IbaG family - - - 0.000000000000000531 85.0
HKD1_k127_6179674_47 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.00000000000003146 80.0
HKD1_k127_6179674_48 - - - - 0.00000000000004081 82.0
HKD1_k127_6179674_49 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372 - 0.0000000002751 70.0
HKD1_k127_6179674_5 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006839 571.0
HKD1_k127_6179674_50 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA K11719 - - 0.000006164 56.0
HKD1_k127_6179674_51 OstA-like protein - - - 0.0001436 51.0
HKD1_k127_6179674_52 - - - - 0.0003809 48.0
HKD1_k127_6179674_6 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 578.0
HKD1_k127_6179674_7 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 571.0
HKD1_k127_6179674_8 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 545.0
HKD1_k127_6179674_9 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 509.0
HKD1_k127_6189857_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1021.0
HKD1_k127_6189857_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.28e-321 997.0
HKD1_k127_6189857_10 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 447.0
HKD1_k127_6189857_11 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005409 419.0
HKD1_k127_6189857_12 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 377.0
HKD1_k127_6189857_13 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006747 362.0
HKD1_k127_6189857_14 NmrA family K19267 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009332 348.0
HKD1_k127_6189857_15 TIGRFAM DNA protecting protein DprA K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 345.0
HKD1_k127_6189857_16 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009176 332.0
HKD1_k127_6189857_17 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009117 338.0
HKD1_k127_6189857_18 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002366 327.0
HKD1_k127_6189857_19 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 306.0
HKD1_k127_6189857_2 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.275e-222 702.0
HKD1_k127_6189857_20 Exodeoxyribonuclease IX - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 301.0
HKD1_k127_6189857_21 PFAM HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006079 284.0
HKD1_k127_6189857_22 Belongs to the GST superfamily K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000011 284.0
HKD1_k127_6189857_23 Lysin motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001762 268.0
HKD1_k127_6189857_24 N-acetyltransferase K00675 - 2.3.1.118 0.00000000000000000000000000000000000000000000000000000000000000000000000014 261.0
HKD1_k127_6189857_25 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000002957 251.0
HKD1_k127_6189857_26 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000001657 234.0
HKD1_k127_6189857_27 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000005643 229.0
HKD1_k127_6189857_28 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.0000000000000000000000000000000000000000000000000000000000002656 221.0
HKD1_k127_6189857_29 - - - - 0.0000000000000000000000000000000000000000000000000008832 205.0
HKD1_k127_6189857_3 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 1.037e-220 708.0
HKD1_k127_6189857_30 Belongs to the P(II) protein family K04751,K04752 - - 0.000000000000000000000000000000000000000000000001345 181.0
HKD1_k127_6189857_31 DNA glycosylase - - - 0.000000000000000000000000000000000000000000000008248 191.0
HKD1_k127_6189857_32 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000003414 179.0
HKD1_k127_6189857_33 translation initiation inhibitor, yjgF family K04782 - 4.2.99.21 0.0000000000000000000000000000000000000000000007755 168.0
HKD1_k127_6189857_34 Cytochrome B561 K12262 - - 0.00000000000000000000000000000000000000001968 158.0
HKD1_k127_6189857_35 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000002962 160.0
HKD1_k127_6189857_36 protein possibly involved in utilization of glycolate and propanediol - - - 0.0000000000000000000000000000000000000001559 154.0
HKD1_k127_6189857_37 NADP transhydrogenase K00324 - 1.6.1.2 0.0000000000000000000000000000000000002656 151.0
HKD1_k127_6189857_38 Belongs to the Smg family K03747 - - 0.0000000000000000000000000000000006881 137.0
HKD1_k127_6189857_39 YceI-like domain - - - 0.000000000000000000000000000000003512 137.0
HKD1_k127_6189857_4 Arginyl-tRNA synthetase K01887 - 6.1.1.19 8.311e-207 669.0
HKD1_k127_6189857_40 Sporulation related domain - - - 0.0000000000000000000000000000002438 133.0
HKD1_k127_6189857_41 Domain of unknown function (DUF4390) - - - 0.00000000000000000000002653 107.0
HKD1_k127_6189857_42 Prolyl oligopeptidase family - - - 0.00000000000000000000007215 114.0
HKD1_k127_6189857_43 Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria - - - 0.00000000000000001852 89.0
HKD1_k127_6189857_44 Thioesterase superfamily - - - 0.000000007904 67.0
HKD1_k127_6189857_45 - - - - 0.000001948 58.0
HKD1_k127_6189857_5 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008496 606.0
HKD1_k127_6189857_6 signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003302 564.0
HKD1_k127_6189857_7 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 525.0
HKD1_k127_6189857_8 Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily K01919 - 6.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006134 486.0
HKD1_k127_6189857_9 phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004653 490.0
HKD1_k127_6243104_0 AAA-like domain - - - 9.046e-254 807.0
HKD1_k127_6243104_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 2.857e-217 689.0
HKD1_k127_6243104_10 COG1566 Multidrug resistance efflux pump K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 371.0
HKD1_k127_6243104_11 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 302.0
HKD1_k127_6243104_12 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000109 291.0
HKD1_k127_6243104_13 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003419 279.0
HKD1_k127_6243104_14 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000002718 256.0
HKD1_k127_6243104_15 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000006179 243.0
HKD1_k127_6243104_16 MarC family integral membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000003628 235.0
HKD1_k127_6243104_17 COG2755 Lysophospholipase L1 and related esterases K10804 GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000398 226.0
HKD1_k127_6243104_18 Periplasmic binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000009551 220.0
HKD1_k127_6243104_19 Prokaryotic N-terminal methylation motif K02655 - - 0.00000000000000000000000000000000000000001932 160.0
HKD1_k127_6243104_2 Acyl-CoA dehydrogenase N terminal K20035 - - 1.19e-197 633.0
HKD1_k127_6243104_20 Indole-3-glycerol phosphate synthase K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.0000000000000000000000000000000000004255 151.0
HKD1_k127_6243104_21 LysR substrate binding domain - - - 0.000000000000000000000000000000000005339 149.0
HKD1_k127_6243104_22 Acid phosphatase homologues K09474 - 3.1.3.2 0.000000000000000000000000000000000007981 150.0
HKD1_k127_6243104_23 CHAT domain - - - 0.000000000000000000000000000000006588 143.0
HKD1_k127_6243104_24 sister chromatid segregation - - - 0.0000000000000000002722 100.0
HKD1_k127_6243104_25 psiF repeat - - - 0.000000000000000001162 90.0
HKD1_k127_6243104_26 helix_turn_helix multiple antibiotic resistance protein K15974 - - 0.00000000000000002139 91.0
HKD1_k127_6243104_27 Putative diguanylate phosphodiesterase - - - 0.000001845 60.0
HKD1_k127_6243104_28 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.0002712 53.0
HKD1_k127_6243104_3 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 588.0
HKD1_k127_6243104_4 Major Facilitator Superfamily K08169 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003226 549.0
HKD1_k127_6243104_5 Major facilitator superfamily K03446 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007156 544.0
HKD1_k127_6243104_6 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 439.0
HKD1_k127_6243104_7 efflux transporter outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005834 409.0
HKD1_k127_6243104_8 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 402.0
HKD1_k127_6243104_9 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005897 387.0
HKD1_k127_6247505_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 3.188e-266 824.0
HKD1_k127_6247505_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 2.534e-205 649.0
HKD1_k127_6247505_10 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 473.0
HKD1_k127_6247505_11 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 469.0
HKD1_k127_6247505_12 amp-dependent synthetase and ligase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008095 465.0
HKD1_k127_6247505_13 pfkB family carbohydrate kinase K00856 - 2.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008657 445.0
HKD1_k127_6247505_14 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 445.0
HKD1_k127_6247505_15 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 423.0
HKD1_k127_6247505_16 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007225 368.0
HKD1_k127_6247505_17 PFAM secretion protein HlyD family protein K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 390.0
HKD1_k127_6247505_18 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000529 353.0
HKD1_k127_6247505_19 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 329.0
HKD1_k127_6247505_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 2.238e-204 643.0
HKD1_k127_6247505_20 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 328.0
HKD1_k127_6247505_21 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007742 314.0
HKD1_k127_6247505_22 Cell wall hydrolase autolysin K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 307.0
HKD1_k127_6247505_23 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 313.0
HKD1_k127_6247505_24 Deoxynucleoside kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002215 270.0
HKD1_k127_6247505_25 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000005904 269.0
HKD1_k127_6247505_26 - - - - 0.0000000000000000000000000000000000000000000000000000000000000004504 229.0
HKD1_k127_6247505_27 Bacterial regulatory helix-turn-helix protein, lysR family K14657 - - 0.0000000000000000000000000000000000000000000000000001294 197.0
HKD1_k127_6247505_28 HflC and HflK could encode or regulate a protease K04088 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000001917 188.0
HKD1_k127_6247505_29 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000002156 169.0
HKD1_k127_6247505_3 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 586.0
HKD1_k127_6247505_30 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016246,GO:0016441,GO:0016458,GO:0017148,GO:0019222,GO:0022607,GO:0022613,GO:0022618,GO:0030423,GO:0031047,GO:0031123,GO:0031124,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032269,GO:0032270,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0035194,GO:0040029,GO:0040033,GO:0043170,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045974,GO:0045975,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000001005 134.0
HKD1_k127_6247505_31 prohibitin homologues K04087 - - 0.0000000000000000000000000000000009766 141.0
HKD1_k127_6247505_32 ATPase or kinase K06925 - - 0.000000000000000000000000000000001835 136.0
HKD1_k127_6247505_33 enoyl-CoA hydratase isomerase - - - 0.000000000000000000000000000002713 132.0
HKD1_k127_6247505_34 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.00000000008382 65.0
HKD1_k127_6247505_4 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 558.0
HKD1_k127_6247505_5 COG2031 Short chain fatty acids transporter K02106 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000482 580.0
HKD1_k127_6247505_6 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008773 561.0
HKD1_k127_6247505_7 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005811 518.0
HKD1_k127_6247505_8 PFAM FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 494.0
HKD1_k127_6247505_9 ribosomal rna small subunit methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 481.0
HKD1_k127_6276884_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0 1072.0
HKD1_k127_6276884_1 Belongs to the ClpA ClpB family K03694 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - 0.0 1020.0
HKD1_k127_6276884_10 ATPase, AAA K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 549.0
HKD1_k127_6276884_11 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008819 494.0
HKD1_k127_6276884_12 general secretion pathway protein D K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003865 506.0
HKD1_k127_6276884_13 General secretion pathway protein F K02455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003308 447.0
HKD1_k127_6276884_14 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005663 445.0
HKD1_k127_6276884_15 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 429.0
HKD1_k127_6276884_16 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 390.0
HKD1_k127_6276884_17 Major Facilitator Superfamily K13021 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000481 397.0
HKD1_k127_6276884_18 Lipoprotein releasing system transmembrane protein K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005279 406.0
HKD1_k127_6276884_19 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005696 379.0
HKD1_k127_6276884_2 calcium- and calmodulin-responsive adenylate cyclase activity K01179 - 3.2.1.4 4.989e-300 936.0
HKD1_k127_6276884_20 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 388.0
HKD1_k127_6276884_21 Peptidogalycan biosysnthesis/recognition K09919 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003175 370.0
HKD1_k127_6276884_22 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005899 333.0
HKD1_k127_6276884_23 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 336.0
HKD1_k127_6276884_24 Sugar (and other) transporter K08195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 330.0
HKD1_k127_6276884_25 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 316.0
HKD1_k127_6276884_26 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006402 331.0
HKD1_k127_6276884_27 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006336 313.0
HKD1_k127_6276884_28 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 307.0
HKD1_k127_6276884_29 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 302.0
HKD1_k127_6276884_3 DNA segregation ATPase FtsK SpoIIIE K03466 - - 1.428e-260 825.0
HKD1_k127_6276884_30 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005303 299.0
HKD1_k127_6276884_31 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001287 282.0
HKD1_k127_6276884_32 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000007161 258.0
HKD1_k127_6276884_33 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000001315 264.0
HKD1_k127_6276884_34 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000000000000000000000000000000000000005566 252.0
HKD1_k127_6276884_35 PFAM MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000008222 229.0
HKD1_k127_6276884_36 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000005131 206.0
HKD1_k127_6276884_37 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000001299 203.0
HKD1_k127_6276884_38 CYTH domain protein K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000002271 171.0
HKD1_k127_6276884_39 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000006843 169.0
HKD1_k127_6276884_4 Belongs to the TPP enzyme family K01652 - 2.2.1.6 2.029e-239 756.0
HKD1_k127_6276884_40 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 GO:0003674,GO:0005488,GO:0005515,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896,GO:0051087 - 0.000000000000000000000000000000000000008367 147.0
HKD1_k127_6276884_41 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.00000000000000000000000000000000000002516 151.0
HKD1_k127_6276884_42 protein conserved in bacteria K09928 - - 0.00000000000000000000000000000000007712 143.0
HKD1_k127_6276884_43 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000009291 128.0
HKD1_k127_6276884_44 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.0000000000000000000000000006103 121.0
HKD1_k127_6276884_45 General secretion pathway protein C K02452 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.000000000000000000000000003218 123.0
HKD1_k127_6276884_46 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.0000000000000000000000007098 110.0
HKD1_k127_6276884_47 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.0000000000000000000002693 97.0
HKD1_k127_6276884_48 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000003121 104.0
HKD1_k127_6276884_49 Belongs to the UPF0434 family K09791 - - 0.00000000000000003801 94.0
HKD1_k127_6276884_5 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 3.725e-212 687.0
HKD1_k127_6276884_50 - - - - 0.000000000000001636 79.0
HKD1_k127_6276884_51 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000008097 73.0
HKD1_k127_6276884_52 Peptidoglycan-binding protein, CsiV - - - 0.00000000000508 75.0
HKD1_k127_6276884_53 PFAM VanZ - - - 0.00000000006492 72.0
HKD1_k127_6276884_54 metal-binding, possibly nucleic acid-binding protein K07040 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000002338 67.0
HKD1_k127_6276884_6 PFAM Type II secretion system protein E K02454 - - 4.402e-202 643.0
HKD1_k127_6276884_7 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004518 560.0
HKD1_k127_6276884_8 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009149 546.0
HKD1_k127_6276884_9 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 553.0
HKD1_k127_6281923_0 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - 6.065e-271 849.0
HKD1_k127_6281923_1 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K12141 - - 2.674e-242 755.0
HKD1_k127_6281923_2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 556.0
HKD1_k127_6281923_3 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009165 452.0
HKD1_k127_6281923_4 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 GO:0000166,GO:0003674,GO:0003824,GO:0003960,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0010941,GO:0016491,GO:0016651,GO:0016655,GO:0019362,GO:0019637,GO:0034641,GO:0036094,GO:0042802,GO:0042803,GO:0042981,GO:0043067,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0048038,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0051186,GO:0055086,GO:0055114,GO:0065007,GO:0070402,GO:0071704,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006503 440.0
HKD1_k127_6281923_5 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 430.0
HKD1_k127_6281923_6 hydrogenase 4 membrane K12140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002849 264.0
HKD1_k127_6281923_7 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000183 148.0
HKD1_k127_6281923_8 Aspartyl asparaginyl beta-hydroxylase and related dioxygenases K12979 - - 0.00000000000000000000000000001244 120.0
HKD1_k127_6281923_9 PFAM CopG domain protein DNA-binding domain protein - - - 0.000000000000000001524 87.0
HKD1_k127_6430885_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04099,K04101 - 1.13.11.57,1.13.11.8 6.104e-206 648.0
HKD1_k127_6430885_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 535.0
HKD1_k127_6430885_2 ABC-2 type transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000936 378.0
HKD1_k127_6430885_3 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008488 351.0
HKD1_k127_6430885_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002288 253.0
HKD1_k127_6430885_5 Domain of unknown function (DUF1932) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001982 257.0
HKD1_k127_6430885_6 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.000000000000000000000000000000000000000000003097 184.0
HKD1_k127_6430885_7 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 0.000000000000000000000000000000007978 130.0
HKD1_k127_6430885_8 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000002459 72.0
HKD1_k127_6430885_9 His Kinase A (phosphoacceptor) domain - - - 0.0000005028 61.0
HKD1_k127_6441269_0 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 405.0
HKD1_k127_6441269_1 exporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004429 386.0
HKD1_k127_6441269_2 Bacterial lipid A biosynthesis acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004071 341.0
HKD1_k127_6441269_3 Outer membrane lipoprotein carrier protein LolA - - - 0.00000000000000000000000000000000000000001261 162.0
HKD1_k127_6441269_4 membrane - - - 0.00000000000000000000000000002168 127.0
HKD1_k127_6441269_5 FabA-like domain - - - 0.000000000000008188 78.0
HKD1_k127_6441269_6 Phosphopantetheine attachment site K02078 - - 0.00000000000004569 72.0
HKD1_k127_6458794_0 FAD dependent oxidoreductase central domain - - - 0.0 1265.0
HKD1_k127_6458794_1 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 1.634e-312 966.0
HKD1_k127_6458794_10 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 377.0
HKD1_k127_6458794_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009706 374.0
HKD1_k127_6458794_12 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005386 362.0
HKD1_k127_6458794_13 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 315.0
HKD1_k127_6458794_15 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007347 256.0
HKD1_k127_6458794_16 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000008041 243.0
HKD1_k127_6458794_17 ParB-like nuclease - - - 0.0000000000000000000000000000000000000000000000000000000001843 211.0
HKD1_k127_6458794_18 Carbon-nitrogen hydrolase K03820 - - 0.000000000000000000000000000000000000000000000000000000001016 220.0
HKD1_k127_6458794_19 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000003958 186.0
HKD1_k127_6458794_2 Conserved carboxylase domain K01571 - 4.1.1.3 4.004e-236 743.0
HKD1_k127_6458794_20 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000004389 139.0
HKD1_k127_6458794_21 MgtC family K07507 - - 0.0000000000000000000000000000006341 131.0
HKD1_k127_6458794_22 Repeat of Unknown Function (DUF347) - - - 0.0000000000000000000001739 98.0
HKD1_k127_6458794_23 photosystem II stabilization K02237 - - 0.000000000000000000001219 100.0
HKD1_k127_6458794_24 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component - - - 0.0000000000000000003571 98.0
HKD1_k127_6458794_3 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 5.6e-207 651.0
HKD1_k127_6458794_4 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 577.0
HKD1_k127_6458794_5 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 463.0
HKD1_k127_6458794_6 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 463.0
HKD1_k127_6458794_7 Retinal pigment epithelial membrane protein K11159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 458.0
HKD1_k127_6458794_8 PFAM NnrS family protein K07234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 480.0
HKD1_k127_6458794_9 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006748 417.0
HKD1_k127_6481390_0 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 618.0
HKD1_k127_6481390_1 Aminotransferase class-III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 576.0
HKD1_k127_6481390_10 Domain of unknown function (DUF4382) - - - 0.00000000000000000000000000007529 128.0
HKD1_k127_6481390_11 GntR family transcriptional regulator K11475 - - 0.0008326 44.0
HKD1_k127_6481390_2 Uncharacterised protein family (UPF0261) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 518.0
HKD1_k127_6481390_3 Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 484.0
HKD1_k127_6481390_4 Amino acid permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002013 329.0
HKD1_k127_6481390_5 Subtilase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 313.0
HKD1_k127_6481390_6 Haloacid dehalogenase-like hydrolase K07025 - - 0.000000000000000000000000000000000000000000000000000000000000001875 230.0
HKD1_k127_6481390_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000000000000000000001198 201.0
HKD1_k127_6481390_8 Sigma-70, region 4 - - - 0.00000000000000000000000000000000000000000000000001737 184.0
HKD1_k127_6481390_9 AntiSigma factor - - - 0.000000000000000000000000000000000000001795 160.0
HKD1_k127_6625087_0 TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family K03296,K18138 - - 0.0 1163.0
HKD1_k127_6625087_1 receptor - - - 9.432e-286 899.0
HKD1_k127_6625087_2 COG0457 FOG TPR repeat - - - 5.017e-261 818.0
HKD1_k127_6625087_3 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00529 - 1.18.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 426.0
HKD1_k127_6625087_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 373.0
HKD1_k127_6625087_5 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 312.0
HKD1_k127_6625087_6 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.000000000000000000000000000004446 122.0
HKD1_k127_6806404_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 2.24e-245 779.0
HKD1_k127_6806404_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005797 518.0
HKD1_k127_6806404_10 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000003881 177.0
HKD1_k127_6806404_11 salt-induced outer membrane protein K07283 - - 0.00000000000000000000000000000000000003476 154.0
HKD1_k127_6806404_12 Domain of unknown function (DUF4337) - - - 0.00000000000000000000000000000000000006006 149.0
HKD1_k127_6806404_13 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.0000000000000000000000000000000006751 135.0
HKD1_k127_6806404_14 Protein of unknown function (DUF3313) - - - 0.00000000000000000000000000000006431 132.0
HKD1_k127_6806404_15 COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000001449 131.0
HKD1_k127_6806404_16 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000277 106.0
HKD1_k127_6806404_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 475.0
HKD1_k127_6806404_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 433.0
HKD1_k127_6806404_4 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009832 326.0
HKD1_k127_6806404_5 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 331.0
HKD1_k127_6806404_6 Short-chain dehydrogenase reductase SDR K00059,K03793 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008667,GO:0009058,GO:0009237,GO:0009238,GO:0009239,GO:0009712,GO:0009713,GO:0009987,GO:0016043,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0018958,GO:0019184,GO:0019290,GO:0019438,GO:0019540,GO:0019748,GO:0022607,GO:0034641,GO:0042802,GO:0043043,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046189,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.100,1.5.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 288.0
HKD1_k127_6806404_7 nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007469 241.0
HKD1_k127_6806404_8 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.0000000000000000000000000000000000000000000000000003061 187.0
HKD1_k127_6806404_9 Yqey-like protein K09117 - - 0.000000000000000000000000000000000000000000000001441 179.0
HKD1_k127_6966466_0 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000001089 192.0
HKD1_k127_6966466_1 Isochorismatase family K13995 - 3.5.1.107 0.0000000000000000000000000000000000000008674 150.0
HKD1_k127_6966466_2 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000525 161.0
HKD1_k127_7054131_0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000004783 224.0
HKD1_k127_7054131_1 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000003257 212.0
HKD1_k127_7054131_2 Domain of unknown function (DUF1840) - - - 0.00000000000000000576 92.0
HKD1_k127_7082619_0 sulphate transporter - - - 1.306e-197 629.0
HKD1_k127_7082619_1 PFAM Polyphosphate kinase 2 K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 445.0
HKD1_k127_7082619_2 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005193 286.0
HKD1_k127_7082619_3 PFAM Orn Lys Arg decarboxylase major region K01581,K01584 - 4.1.1.17,4.1.1.19 0.000000000000000000000002427 103.0
HKD1_k127_7084012_0 Aldehyde dehydrogenase family K00130,K00137 - 1.2.1.19,1.2.1.8 1.632e-233 734.0
HKD1_k127_7084012_1 Serine carboxypeptidase - - - 1.157e-226 740.0
HKD1_k127_7084012_10 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006863 329.0
HKD1_k127_7084012_11 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 298.0
HKD1_k127_7084012_12 DNA mediated transformation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004858 302.0
HKD1_k127_7084012_13 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000106 289.0
HKD1_k127_7084012_14 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000003908 256.0
HKD1_k127_7084012_15 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000002149 203.0
HKD1_k127_7084012_16 MAPEG family - - - 0.000000000000000000000000000000000000000002842 159.0
HKD1_k127_7084012_17 - - - - 0.0000000000000000000000000000000000000000275 159.0
HKD1_k127_7084012_18 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000000000000000000000000005991 143.0
HKD1_k127_7084012_19 NNMT/PNMT/TEMT family K00562 - 2.1.1.49,2.1.1.96 0.000000000000000000000000000000000006993 146.0
HKD1_k127_7084012_2 Bacterial protein of unknown function (DUF885) - - - 8.478e-206 667.0
HKD1_k127_7084012_20 - - - - 0.0000000000000000000000001015 111.0
HKD1_k127_7084012_21 Protein involved in outer membrane biogenesis K07289 - - 0.0000000000000003268 91.0
HKD1_k127_7084012_3 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 629.0
HKD1_k127_7084012_4 COG3209 Rhs family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 597.0
HKD1_k127_7084012_5 lipoprotein releasing system, transmembrane protein, LolC E family K09808 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0098796,GO:0098797 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 541.0
HKD1_k127_7084012_6 Protein involved in receptor activity and transport K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 488.0
HKD1_k127_7084012_7 Amino acid permease K11735 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 474.0
HKD1_k127_7084012_8 TIGRFAM A G-specific adenine glycosylase K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 384.0
HKD1_k127_7084012_9 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 334.0
HKD1_k127_7084785_0 Bacterial protein of unknown function (DUF885) - - - 5.411e-210 663.0
HKD1_k127_7084785_1 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002194 370.0
HKD1_k127_7084785_2 cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005097 338.0
HKD1_k127_7084785_3 signal sequence binding - - - 0.00000000000000000000000000000000000003078 155.0
HKD1_k127_7084785_4 SURF1-like protein - - - 0.00000000000000000000000003488 112.0
HKD1_k127_7084785_5 VanZ like family - - - 0.00000001189 67.0
HKD1_k127_7152022_0 B12 binding domain K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0 1585.0
HKD1_k127_7152022_1 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0 1440.0
HKD1_k127_7152022_10 Aminotransferase class I and II K09758 - 4.1.1.12 1.138e-231 736.0
HKD1_k127_7152022_100 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003119 326.0
HKD1_k127_7152022_101 Acyl-CoA thioesterase K10805 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 320.0
HKD1_k127_7152022_102 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 306.0
HKD1_k127_7152022_103 PFAM Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008098 305.0
HKD1_k127_7152022_104 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 311.0
HKD1_k127_7152022_105 Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system K02056,K05776,K10441,K10539,K10542,K10545,K10548 - 3.6.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 306.0
HKD1_k127_7152022_106 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 302.0
HKD1_k127_7152022_107 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 289.0
HKD1_k127_7152022_108 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 293.0
HKD1_k127_7152022_109 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 294.0
HKD1_k127_7152022_11 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 7.999e-224 724.0
HKD1_k127_7152022_110 membrane protein, TerC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000203 284.0
HKD1_k127_7152022_111 Hpt domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004548 302.0
HKD1_k127_7152022_112 cytochrome - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005247 283.0
HKD1_k127_7152022_113 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002137 291.0
HKD1_k127_7152022_114 LysR substrate binding domain K18900 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001591 272.0
HKD1_k127_7152022_115 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.000000000000000000000000000000000000000000000000000000000000000000000000000005185 271.0
HKD1_k127_7152022_116 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000694 280.0
HKD1_k127_7152022_117 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000001141 271.0
HKD1_k127_7152022_118 Histidine kinase K14986 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000005074 277.0
HKD1_k127_7152022_119 Bacterial transcriptional repressor C-terminal K16137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007381 262.0
HKD1_k127_7152022_12 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.666e-223 702.0
HKD1_k127_7152022_120 PFAM MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001669 263.0
HKD1_k127_7152022_121 Methyltransferase domain K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000003071 264.0
HKD1_k127_7152022_122 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005403 284.0
HKD1_k127_7152022_123 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000006977 265.0
HKD1_k127_7152022_124 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000001159 257.0
HKD1_k127_7152022_125 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000002672 263.0
HKD1_k127_7152022_126 Sugar (and other) transporter K08151 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000271 264.0
HKD1_k127_7152022_127 cytochrome c oxidase (Subunit II) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002811 248.0
HKD1_k127_7152022_128 Nudix N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000287 236.0
HKD1_k127_7152022_129 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000000000000000000000000000000000000000000000000004908 237.0
HKD1_k127_7152022_13 Isocitrate dehydrogenase - - - 4.144e-222 696.0
HKD1_k127_7152022_130 2Fe-2S -binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000005691 239.0
HKD1_k127_7152022_131 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000004468 237.0
HKD1_k127_7152022_132 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000007923 239.0
HKD1_k127_7152022_133 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000862 236.0
HKD1_k127_7152022_134 s cog2930 - - - 0.000000000000000000000000000000000000000000000000000000000000001812 226.0
HKD1_k127_7152022_135 Protein of unknown function (DUF1203) - - - 0.000000000000000000000000000000000000000000000000000000000000004335 224.0
HKD1_k127_7152022_136 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533,K15396 - 2.1.1.200 0.00000000000000000000000000000000000000000000000000000000000002709 222.0
HKD1_k127_7152022_137 TspO/MBR family K05770 - - 0.00000000000000000000000000000000000000000000000000000000000005432 218.0
HKD1_k127_7152022_138 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000000000000000000000000000000000000000000001074 217.0
HKD1_k127_7152022_139 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000001853 216.0
HKD1_k127_7152022_14 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 1.263e-219 694.0
HKD1_k127_7152022_140 signal sequence binding K07152 - - 0.00000000000000000000000000000000000000000000000000000000006511 224.0
HKD1_k127_7152022_141 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000002383 218.0
HKD1_k127_7152022_142 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.00000000000000000000000000000000000000000000000000000001763 199.0
HKD1_k127_7152022_143 - - - - 0.00000000000000000000000000000000000000000000000000000003048 205.0
HKD1_k127_7152022_144 Cupin - - - 0.00000000000000000000000000000000000000000000000000000004676 199.0
HKD1_k127_7152022_145 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000000000000000000000000000005424 207.0
HKD1_k127_7152022_146 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000000000000000000000000000000006619 201.0
HKD1_k127_7152022_147 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000000222 192.0
HKD1_k127_7152022_148 - - - - 0.00000000000000000000000000000000000000000000000000002243 198.0
HKD1_k127_7152022_149 COG3103 SH3 domain protein - - - 0.00000000000000000000000000000000000000000000000000005321 196.0
HKD1_k127_7152022_15 L-aspartate oxidase K00278 - 1.4.3.16 1.227e-216 689.0
HKD1_k127_7152022_150 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000000000000000000000000000002422 196.0
HKD1_k127_7152022_151 - - - - 0.000000000000000000000000000000000000000000000000001033 194.0
HKD1_k127_7152022_152 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000001007 194.0
HKD1_k127_7152022_153 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000002716 181.0
HKD1_k127_7152022_154 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase - - - 0.0000000000000000000000000000000000000000000000003414 183.0
HKD1_k127_7152022_155 formate dehydrogenase - - - 0.000000000000000000000000000000000000000000000001905 183.0
HKD1_k127_7152022_156 Thioredoxin-like [2Fe-2S] ferredoxin - - - 0.00000000000000000000000000000000000000000000001414 176.0
HKD1_k127_7152022_158 Arac family - - - 0.000000000000000000000000000000000000000000001133 179.0
HKD1_k127_7152022_159 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000001666 182.0
HKD1_k127_7152022_16 xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 2.823e-214 693.0
HKD1_k127_7152022_160 - - - - 0.0000000000000000000000000000000000000000000424 165.0
HKD1_k127_7152022_161 Rhomboid family - - - 0.00000000000000000000000000000000000000000004243 168.0
HKD1_k127_7152022_162 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000004614 171.0
HKD1_k127_7152022_163 PFAM AMP-dependent synthetase and ligase K00666 - - 0.00000000000000000000000000000000000000000006819 170.0
HKD1_k127_7152022_164 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000001019 165.0
HKD1_k127_7152022_165 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000000000000000000000000000000000000001386 168.0
HKD1_k127_7152022_166 - - - - 0.00000000000000000000000000000000000000009384 160.0
HKD1_k127_7152022_168 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01907 - 6.2.1.16 0.00000000000000000000000000000000000007268 146.0
HKD1_k127_7152022_169 cheY-homologous receiver domain K03412,K03413 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000001617 150.0
HKD1_k127_7152022_17 Tetratricopeptide repeat - - - 3.74e-212 699.0
HKD1_k127_7152022_170 FMN-binding domain protein - - - 0.0000000000000000000000000000000000001867 148.0
HKD1_k127_7152022_171 - - - - 0.0000000000000000000000000000000000008191 151.0
HKD1_k127_7152022_173 Chemotaxis phosphatase CheX K03409 - - 0.000000000000000000000000000000000007378 141.0
HKD1_k127_7152022_174 Is able to transfer iron-sulfur clusters to apo- ferredoxin. Multiple cycles of 2Fe2S cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system K13628 - - 0.000000000000000000000000000000000008132 145.0
HKD1_k127_7152022_175 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000002872 142.0
HKD1_k127_7152022_176 Protein of unknown function (DUF1272) - - - 0.00000000000000000000000000000000004559 136.0
HKD1_k127_7152022_177 Biopolymer transport protein ExbD/TolR - - - 0.00000000000000000000000000000000006257 146.0
HKD1_k127_7152022_178 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000003906 141.0
HKD1_k127_7152022_179 type IV pilus biogenesis stability protein PilW K02656 - - 0.0000000000000000000000000000000008617 150.0
HKD1_k127_7152022_18 - - - - 7.288e-208 658.0
HKD1_k127_7152022_180 COG3201 Nicotinamide mononucleotide transporter K03811 - - 0.000000000000000000000000000000004634 136.0
HKD1_k127_7152022_181 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.00000000000000000000000000000003069 132.0
HKD1_k127_7152022_182 ApbE family - - - 0.0000000000000000000000000000004389 132.0
HKD1_k127_7152022_183 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000002156 126.0
HKD1_k127_7152022_184 Preprotein translocase, YajC subunit K03210 - - 0.00000000000000000000000000001246 121.0
HKD1_k127_7152022_185 TIR domain - - - 0.00000000000000000000000000006511 134.0
HKD1_k127_7152022_186 Biopolymer transport protein ExbD/TolR - - - 0.00000000000000000000000000009357 121.0
HKD1_k127_7152022_187 Cytochrome c-type biogenesis protein K02200 - - 0.00000000000000000000000000009953 131.0
HKD1_k127_7152022_188 ferredoxin K04755 - - 0.0000000000000000000000000007939 117.0
HKD1_k127_7152022_189 Glycine zipper 2TM domain - - - 0.000000000000000000000000002571 120.0
HKD1_k127_7152022_19 TonB dependent receptor K02014 - - 1.322e-207 673.0
HKD1_k127_7152022_190 Thioredoxin-like - - - 0.000000000000000000000000009787 117.0
HKD1_k127_7152022_191 - - - - 0.00000000000000000000000003535 113.0
HKD1_k127_7152022_192 - - - - 0.0000000000000000000000001264 124.0
HKD1_k127_7152022_193 Protein of unknown function (DUF2844) - - - 0.0000000000000000000000004197 110.0
HKD1_k127_7152022_194 protein conserved in bacteria - - - 0.000000000000000000000004834 109.0
HKD1_k127_7152022_195 oxygen carrier activity K07216 - - 0.000000000000000000000005396 106.0
HKD1_k127_7152022_196 spectrin binding - - - 0.0000000000000000000000099 117.0
HKD1_k127_7152022_197 - - - - 0.00000000000000000000003872 105.0
HKD1_k127_7152022_198 PFAM uncharacterised conserved protein UCP030820 - - - 0.0000000000000000000008987 104.0
HKD1_k127_7152022_199 Domain of unknown function (DUF4266) - - - 0.0000000000000000000009856 98.0
HKD1_k127_7152022_2 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 1.083e-281 879.0
HKD1_k127_7152022_20 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00124 - - 1.751e-207 659.0
HKD1_k127_7152022_200 COG1734 DnaK suppressor protein - - - 0.00000000000000000001454 95.0
HKD1_k127_7152022_201 - - - - 0.00000000000000000002238 97.0
HKD1_k127_7152022_202 - - - - 0.00000000000000000008694 95.0
HKD1_k127_7152022_203 Belongs to the UPF0235 family K09131 - - 0.0000000000000000002122 100.0
HKD1_k127_7152022_204 Protein of unknown function (DUF2905) - - - 0.000000000000000000255 90.0
HKD1_k127_7152022_205 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.0000000000000000004923 94.0
HKD1_k127_7152022_206 Beta-lactamase - - - 0.000000000000000003031 97.0
HKD1_k127_7152022_207 - - - - 0.00000000000000001202 95.0
HKD1_k127_7152022_208 YKOF-related Family - - - 0.00000000000000003522 83.0
HKD1_k127_7152022_209 Choline/ethanolamine kinase - - - 0.000000000000001902 87.0
HKD1_k127_7152022_21 Peptidase family M28 - - - 1.99e-204 651.0
HKD1_k127_7152022_210 Acetyltransferase (GNAT) domain - - - 0.000000000000002082 83.0
HKD1_k127_7152022_211 TPR repeat - - - 0.000000000000006882 90.0
HKD1_k127_7152022_212 - - - - 0.00000000000001111 79.0
HKD1_k127_7152022_213 - - - - 0.0000000000001616 72.0
HKD1_k127_7152022_214 protein conserved in bacteria K15539 - - 0.0000000000008036 79.0
HKD1_k127_7152022_215 NADH-dependant formate dehydrogenase delta subunit FdsD K00126 - 1.17.1.9 0.000000000001865 70.0
HKD1_k127_7152022_216 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000003005 66.0
HKD1_k127_7152022_217 ketosteroid isomerase - - - 0.000000000193 70.0
HKD1_k127_7152022_218 Trypsin-like serine protease - - - 0.000000002194 59.0
HKD1_k127_7152022_219 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000000004867 69.0
HKD1_k127_7152022_22 exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 1.724e-199 632.0
HKD1_k127_7152022_220 COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases K01907 - 6.2.1.16 0.000000009939 64.0
HKD1_k127_7152022_221 NifU-like N terminal domain - - - 0.00000001284 63.0
HKD1_k127_7152022_222 Cbb3-type cytochrome oxidase K00407 - - 0.00000005474 59.0
HKD1_k127_7152022_223 Regulator of ribonuclease activity B - - - 0.00000005502 60.0
HKD1_k127_7152022_224 - - - - 0.00000009034 57.0
HKD1_k127_7152022_225 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000001453 53.0
HKD1_k127_7152022_226 - - - - 0.0000001649 59.0
HKD1_k127_7152022_227 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000209 54.0
HKD1_k127_7152022_228 Cytochrome oxidase maturation protein - - - 0.0000003934 57.0
HKD1_k127_7152022_229 - - - - 0.000001136 53.0
HKD1_k127_7152022_23 Alpha/beta hydrolase of unknown function (DUF1100) - - - 9.811e-198 635.0
HKD1_k127_7152022_232 - - - - 0.0004458 49.0
HKD1_k127_7152022_233 Sel1-like repeats. K07126 - - 0.0004808 53.0
HKD1_k127_7152022_234 - - - - 0.0005061 44.0
HKD1_k127_7152022_24 COG2217 Cation transport ATPase K01533 - 3.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006653 593.0
HKD1_k127_7152022_25 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K07250 - 2.6.1.19,2.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008534 578.0
HKD1_k127_7152022_26 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007131 574.0
HKD1_k127_7152022_27 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005324 555.0
HKD1_k127_7152022_28 PFAM Radical SAM K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 551.0
HKD1_k127_7152022_29 IG-like fold at C-terminal of FixG, putative oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 559.0
HKD1_k127_7152022_3 GTP-binding protein TypA K06207 - - 1.227e-280 878.0
HKD1_k127_7152022_30 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 574.0
HKD1_k127_7152022_31 C-terminus of AA_permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004868 541.0
HKD1_k127_7152022_32 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 538.0
HKD1_k127_7152022_33 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 543.0
HKD1_k127_7152022_34 PFAM tRNA synthetase class II (G H P and S) K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004297 513.0
HKD1_k127_7152022_35 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 511.0
HKD1_k127_7152022_36 TonB-dependent receptor plug K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 521.0
HKD1_k127_7152022_37 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 524.0
HKD1_k127_7152022_38 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004018 506.0
HKD1_k127_7152022_39 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005305 504.0
HKD1_k127_7152022_4 Concanavalin A-like lectin/glucanases superfamily - - - 1.771e-275 869.0
HKD1_k127_7152022_40 PFAM Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 503.0
HKD1_k127_7152022_41 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 503.0
HKD1_k127_7152022_42 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003361 494.0
HKD1_k127_7152022_43 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007532 486.0
HKD1_k127_7152022_44 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006902 502.0
HKD1_k127_7152022_45 FAD linked oxidases, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 492.0
HKD1_k127_7152022_46 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006511 490.0
HKD1_k127_7152022_47 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004137 483.0
HKD1_k127_7152022_48 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008306 473.0
HKD1_k127_7152022_49 succinate dehydrogenase fumarate reductase, flavoprotein subunit K13796 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005155 473.0
HKD1_k127_7152022_5 ABC-type multidrug transport system ATPase and permease K06147 - - 6.709e-262 869.0
HKD1_k127_7152022_50 Multidrug ABC transporter ATP-binding protein K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003219 456.0
HKD1_k127_7152022_51 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004012 457.0
HKD1_k127_7152022_52 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 453.0
HKD1_k127_7152022_53 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 452.0
HKD1_k127_7152022_54 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 450.0
HKD1_k127_7152022_55 Mycolic acid cyclopropane synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 452.0
HKD1_k127_7152022_56 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 442.0
HKD1_k127_7152022_57 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 462.0
HKD1_k127_7152022_58 desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 441.0
HKD1_k127_7152022_59 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 438.0
HKD1_k127_7152022_6 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 7.393e-255 797.0
HKD1_k127_7152022_60 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 454.0
HKD1_k127_7152022_61 heat shock protein binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 465.0
HKD1_k127_7152022_62 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 440.0
HKD1_k127_7152022_63 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 438.0
HKD1_k127_7152022_64 PFAM Molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 421.0
HKD1_k127_7152022_65 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004438 412.0
HKD1_k127_7152022_66 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004379 411.0
HKD1_k127_7152022_67 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005402 413.0
HKD1_k127_7152022_68 Transport permease protein K01992 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003928 397.0
HKD1_k127_7152022_69 geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004196 406.0
HKD1_k127_7152022_7 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 3.395e-253 788.0
HKD1_k127_7152022_70 FAD binding domain K05712 - 1.14.13.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005309 403.0
HKD1_k127_7152022_71 COG4974 Site-specific recombinase XerD K04763 GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 389.0
HKD1_k127_7152022_72 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 396.0
HKD1_k127_7152022_73 e1 component (alpha subunit) K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004089 389.0
HKD1_k127_7152022_74 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 389.0
HKD1_k127_7152022_75 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 382.0
HKD1_k127_7152022_76 Protein of unknown function (DUF3570) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 383.0
HKD1_k127_7152022_77 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004164 396.0
HKD1_k127_7152022_78 phosphoglycerate mutase activity K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 365.0
HKD1_k127_7152022_79 COG1131 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 364.0
HKD1_k127_7152022_8 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate K00381 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016667,GO:0016673,GO:0019419,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0050311,GO:0055114 1.8.1.2 3.9e-236 741.0
HKD1_k127_7152022_80 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005043 363.0
HKD1_k127_7152022_81 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003007 364.0
HKD1_k127_7152022_82 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002952 374.0
HKD1_k127_7152022_83 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 355.0
HKD1_k127_7152022_84 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008427 377.0
HKD1_k127_7152022_85 Phosphate-selective porin O and P - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 357.0
HKD1_k127_7152022_86 Reduces the stability of FtsZ polymers in the presence of ATP K06916 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 355.0
HKD1_k127_7152022_87 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 345.0
HKD1_k127_7152022_88 Fumarylacetoacetate FAA hydrolase K16171 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000775 351.0
HKD1_k127_7152022_89 COG0303 Molybdopterin biosynthesis enzyme K03750,K07219 - 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 348.0
HKD1_k127_7152022_9 PQQ-like domain K17760 - 1.1.9.1 2.208e-234 746.0
HKD1_k127_7152022_90 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008081 339.0
HKD1_k127_7152022_91 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001 339.0
HKD1_k127_7152022_92 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 334.0
HKD1_k127_7152022_93 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009847 334.0
HKD1_k127_7152022_94 Protein of unknown function (DUF3443) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 343.0
HKD1_k127_7152022_95 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 334.0
HKD1_k127_7152022_96 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 328.0
HKD1_k127_7152022_97 NMT1-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 328.0
HKD1_k127_7152022_98 COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit K00405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 314.0
HKD1_k127_7152022_99 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007075 315.0
HKD1_k127_7203124_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1045.0
HKD1_k127_7203124_1 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955 - 2.7.1.25,2.7.7.4 8.411e-299 944.0
HKD1_k127_7203124_10 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000001386 224.0
HKD1_k127_7203124_11 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000000000002497 186.0
HKD1_k127_7203124_13 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000006203 113.0
HKD1_k127_7203124_14 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000002465 80.0
HKD1_k127_7203124_15 Nickel/cobalt transporter regulator - - - 0.000000000001081 74.0
HKD1_k127_7203124_16 Protein of unknown function (DUF1289) K06938 - - 0.00000006486 58.0
HKD1_k127_7203124_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.903e-227 713.0
HKD1_k127_7203124_3 Oxidoreductase - - - 2.245e-201 638.0
HKD1_k127_7203124_4 MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 583.0
HKD1_k127_7203124_5 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 524.0
HKD1_k127_7203124_6 COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes K00957 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 522.0
HKD1_k127_7203124_7 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003039 263.0
HKD1_k127_7203124_8 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K00851,K01057 - 2.7.1.12,3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000001569 240.0
HKD1_k127_7203124_9 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000008477 242.0
HKD1_k127_7223838_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1173.0
HKD1_k127_7223838_1 modulator of DNA gyrase K03568 - - 1.371e-213 676.0
HKD1_k127_7223838_10 protein involved in formation of curli polymers - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002031 311.0
HKD1_k127_7223838_11 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K03185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 316.0
HKD1_k127_7223838_12 Drug metabolite transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 312.0
HKD1_k127_7223838_13 ribonuclease BN K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004446 291.0
HKD1_k127_7223838_14 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002896 276.0
HKD1_k127_7223838_15 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002624 276.0
HKD1_k127_7223838_16 Type II secretory pathway component ExeA K02450,K12283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006908 276.0
HKD1_k127_7223838_17 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K18800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000108 284.0
HKD1_k127_7223838_18 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000002278 232.0
HKD1_k127_7223838_19 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000002361 241.0
HKD1_k127_7223838_2 peptidase M24B, X-Pro dipeptidase aminopeptidase K01262 - 3.4.11.9 3.272e-199 631.0
HKD1_k127_7223838_20 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.00000000000000000000000000000000000000000000000000000000000000002656 233.0
HKD1_k127_7223838_21 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000003843 221.0
HKD1_k127_7223838_22 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000065 216.0
HKD1_k127_7223838_23 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969,K01488 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000747 216.0
HKD1_k127_7223838_24 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000000000000000000000000000000192 210.0
HKD1_k127_7223838_25 EVE domain - - - 0.00000000000000000000000000000000000000000000000000000000003158 209.0
HKD1_k127_7223838_26 Ribosomal protein S9/S16 K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000004657 196.0
HKD1_k127_7223838_27 Putative bacterial lipoprotein (DUF799) - - - 0.000000000000000000000000000000000000000000000000000000976 207.0
HKD1_k127_7223838_28 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host K05801 - - 0.0000000000000000000000000000000000000000000000000002422 196.0
HKD1_k127_7223838_29 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000003028 183.0
HKD1_k127_7223838_3 COG1530 Ribonucleases G and E K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008642 574.0
HKD1_k127_7223838_30 PFAM Histidine triad (HIT) protein K02503 - - 0.0000000000000000000000000000000000000000000000001183 182.0
HKD1_k127_7223838_31 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000002771 154.0
HKD1_k127_7223838_32 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.177 0.0000000000000000000000000000000000000006017 156.0
HKD1_k127_7223838_33 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000000000000000001494 145.0
HKD1_k127_7223838_34 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000005493 134.0
HKD1_k127_7223838_35 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000008513 125.0
HKD1_k127_7223838_36 Belongs to the UPF0149 family K09895 - - 0.000000000000000000000000002423 118.0
HKD1_k127_7223838_37 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.0000000000000000000003823 100.0
HKD1_k127_7223838_38 Domain of unknown function (DUF4810) - - - 0.000000000000000000001548 100.0
HKD1_k127_7223838_39 Belongs to the UPF0307 family K09889 - - 0.0000000000000001468 83.0
HKD1_k127_7223838_4 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009809 520.0
HKD1_k127_7223838_40 PFAM Mannosyl oligosaccharide glucosidase - - - 0.0000000000009902 70.0
HKD1_k127_7223838_41 TIGRFAM TIGR02449 family protein K09892 - - 0.00000000001505 69.0
HKD1_k127_7223838_43 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.000000001398 71.0
HKD1_k127_7223838_5 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005006 467.0
HKD1_k127_7223838_6 SAICAR synthetase K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002689 413.0
HKD1_k127_7223838_7 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 389.0
HKD1_k127_7223838_8 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 345.0
HKD1_k127_7223838_9 Carbon-nitrogen hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005885 324.0
HKD1_k127_7279245_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 7.556e-273 870.0
HKD1_k127_7279245_1 Biotin-lipoyl like K01993 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005002 474.0
HKD1_k127_7279245_2 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005095 355.0
HKD1_k127_7279245_3 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000005708 218.0
HKD1_k127_7338762_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 0.0 1586.0
HKD1_k127_7338762_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1443.0
HKD1_k127_7338762_10 acyl-CoA synthetase family member 3 K18661,K22133 - 6.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004578 610.0
HKD1_k127_7338762_11 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 590.0
HKD1_k127_7338762_12 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 541.0
HKD1_k127_7338762_13 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006696 495.0
HKD1_k127_7338762_14 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005993 490.0
HKD1_k127_7338762_15 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006272 462.0
HKD1_k127_7338762_16 Domain of Unknown Function (DUF349) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007049 449.0
HKD1_k127_7338762_17 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 425.0
HKD1_k127_7338762_18 chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 447.0
HKD1_k127_7338762_19 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003585 412.0
HKD1_k127_7338762_2 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 5.43e-322 1000.0
HKD1_k127_7338762_20 Converts GTP to 7,8-dihydroneopterin triphosphate K09007 - 3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007277 408.0
HKD1_k127_7338762_21 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003735 411.0
HKD1_k127_7338762_22 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 393.0
HKD1_k127_7338762_23 Orotidine 5'-phosphate decarboxylase / HUMPS family K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 372.0
HKD1_k127_7338762_24 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 380.0
HKD1_k127_7338762_25 transporter, permease K02033,K15581 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 373.0
HKD1_k127_7338762_26 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003962 373.0
HKD1_k127_7338762_27 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008306 360.0
HKD1_k127_7338762_28 oligopeptide ABC transporter, ATP-binding protein K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009478 364.0
HKD1_k127_7338762_29 Oligopeptide/dipeptide transporter, C-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 354.0
HKD1_k127_7338762_3 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 2.575e-288 902.0
HKD1_k127_7338762_30 PFAM histone deacetylase superfamily K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 352.0
HKD1_k127_7338762_31 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003562 359.0
HKD1_k127_7338762_32 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 351.0
HKD1_k127_7338762_33 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07644 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 344.0
HKD1_k127_7338762_34 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004493 326.0
HKD1_k127_7338762_35 N-terminal TM domain of oligopeptide transport permease C K15582 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 332.0
HKD1_k127_7338762_36 KR domain K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 317.0
HKD1_k127_7338762_37 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 314.0
HKD1_k127_7338762_38 PFAM EAL domain K21025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005559 325.0
HKD1_k127_7338762_39 Elongation factor P--(R)-beta-lysine ligase K04568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 312.0
HKD1_k127_7338762_4 ABC transporter - - - 4.32e-283 878.0
HKD1_k127_7338762_40 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 302.0
HKD1_k127_7338762_41 Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 303.0
HKD1_k127_7338762_42 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 - 2.1.1.298 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 293.0
HKD1_k127_7338762_43 PFAM Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000208 297.0
HKD1_k127_7338762_44 Glutamine amidotransferases class-II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002923 276.0
HKD1_k127_7338762_45 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000001427 278.0
HKD1_k127_7338762_46 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003913 256.0
HKD1_k127_7338762_47 Transcriptional regulatory protein, C terminal K07665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001518 257.0
HKD1_k127_7338762_48 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007487 260.0
HKD1_k127_7338762_49 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000108 254.0
HKD1_k127_7338762_5 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.01e-269 843.0
HKD1_k127_7338762_50 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000572 251.0
HKD1_k127_7338762_51 Tellurite resistance protein TehB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008764 250.0
HKD1_k127_7338762_52 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000009262 221.0
HKD1_k127_7338762_53 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000002234 231.0
HKD1_k127_7338762_54 Protein of unknown function (DUF3501) - - - 0.00000000000000000000000000000000000000000000000000000000000006476 233.0
HKD1_k127_7338762_55 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000001027 217.0
HKD1_k127_7338762_56 COG3170 Tfp pilus assembly protein FimV K08086 - - 0.000000000000000000000000000000000000000000000000000000000005179 237.0
HKD1_k127_7338762_57 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000002303 198.0
HKD1_k127_7338762_58 Thioredoxin K03672 - 1.8.1.8 0.000000000000000000000000000000000000000000006442 171.0
HKD1_k127_7338762_59 - - - - 0.0000000000000000000000000000000000000002118 158.0
HKD1_k127_7338762_6 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.555e-226 711.0
HKD1_k127_7338762_60 Domain of unknown function (DUF1820) - - - 0.000000000000000000000000000000000000003109 149.0
HKD1_k127_7338762_61 redox protein regulator of disulfide bond formation - - - 0.000000000000000000000000000000000000009271 149.0
HKD1_k127_7338762_62 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000005987 141.0
HKD1_k127_7338762_63 PFAM electron transport protein SCO1 SenC K07152 - - 0.00000000000000000000000000000000004618 143.0
HKD1_k127_7338762_64 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000004812 142.0
HKD1_k127_7338762_65 Sulfurtransferase - - - 0.0000000000000000000000000000584 119.0
HKD1_k127_7338762_66 PFAM Bacterial regulatory protein, arsR family K22298 - - 0.0000000000000000000000002933 121.0
HKD1_k127_7338762_67 Type VI secretion K07169,K11894,K11913 - - 0.000000000000000000000003527 116.0
HKD1_k127_7338762_68 - - - - 0.000000000000000000002673 94.0
HKD1_k127_7338762_69 Colicin V production protein K03558 - - 0.00000000000000000004227 97.0
HKD1_k127_7338762_7 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 5.602e-225 702.0
HKD1_k127_7338762_70 Bacterial protein of unknown function (DUF937) - - - 0.0000000000000000002698 94.0
HKD1_k127_7338762_71 - - - - 0.0000000000000000003168 92.0
HKD1_k127_7338762_72 Cytochrome c554 and c-prime - - - 0.00000000000000004124 97.0
HKD1_k127_7338762_73 - - - - 0.0000000000000001791 84.0
HKD1_k127_7338762_74 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.000000000000001447 81.0
HKD1_k127_7338762_75 protein conserved in bacteria - - - 0.000004136 57.0
HKD1_k127_7338762_76 - - - - 0.000005261 52.0
HKD1_k127_7338762_77 DNA mediated transformation - - - 0.00001178 51.0
HKD1_k127_7338762_78 - - - - 0.00001476 48.0
HKD1_k127_7338762_8 Cysteine-rich domain - - - 8.098e-205 649.0
HKD1_k127_7338762_9 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 2.617e-199 629.0
HKD1_k127_747649_1 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 332.0
HKD1_k127_7503711_0 Oxidoreductase - - - 1.879e-303 938.0
HKD1_k127_7503711_1 Thi4 family - - - 1.777e-196 625.0
HKD1_k127_7503711_2 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 308.0
HKD1_k127_7503711_3 Glycine cleavage T-protein C-terminal barrel domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002583 224.0
HKD1_k127_7670328_0 acyl-CoA dehydrogenase K06445 GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 - 1.465e-286 902.0
HKD1_k127_7670328_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009183 462.0
HKD1_k127_7670328_2 AAA domain K02450,K12283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007156 421.0
HKD1_k127_7670328_3 PFAM transferase hexapeptide repeat containing protein K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002477 313.0
HKD1_k127_7670328_4 Type II secretion system protein B K02451 - - 0.000000004842 66.0
HKD1_k127_78887_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 - 5.4.99.13 0.0 1455.0
HKD1_k127_78887_1 Carboxyl transferase domain K01969 - 6.4.1.4 1.345e-278 863.0
HKD1_k127_78887_10 2-Nitropropane dioxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 503.0
HKD1_k127_78887_11 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000724 487.0
HKD1_k127_78887_12 beta-keto acid cleavage enzyme K18013 - 2.3.1.247 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 484.0
HKD1_k127_78887_13 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 486.0
HKD1_k127_78887_14 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000759 499.0
HKD1_k127_78887_15 Glutathione S-transferase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006024 437.0
HKD1_k127_78887_16 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008853 436.0
HKD1_k127_78887_17 KR domain K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007467 406.0
HKD1_k127_78887_18 Transfers a succinyl group from succinyl-CoA to L- serine, forming succinyl-L-serine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 410.0
HKD1_k127_78887_19 ABC transporter K01995,K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 406.0
HKD1_k127_78887_2 Biotin carboxylase C-terminal domain K01968 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.4 3.394e-234 742.0
HKD1_k127_78887_20 alpha/beta hydrolase fold K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007954 393.0
HKD1_k127_78887_21 Methionine synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009895 371.0
HKD1_k127_78887_22 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008133 356.0
HKD1_k127_78887_23 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 330.0
HKD1_k127_78887_24 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 332.0
HKD1_k127_78887_25 Transcriptional regulator K13634 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 333.0
HKD1_k127_78887_26 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002949 324.0
HKD1_k127_78887_27 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005032 344.0
HKD1_k127_78887_28 Methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 317.0
HKD1_k127_78887_29 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003495 288.0
HKD1_k127_78887_3 Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 6.136e-234 760.0
HKD1_k127_78887_30 Belongs to the pseudouridine synthase RsuA family K06178 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000004673 261.0
HKD1_k127_78887_31 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006406 258.0
HKD1_k127_78887_32 Amidinotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000008374 249.0
HKD1_k127_78887_33 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000004994 251.0
HKD1_k127_78887_34 helix_turn_helix isocitrate lyase regulation - - - 0.0000000000000000000000000000000000000000000000000000000000000000006693 237.0
HKD1_k127_78887_35 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000001883 239.0
HKD1_k127_78887_36 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000006257 222.0
HKD1_k127_78887_37 Transcriptional regulator, AraC family - - - 0.0000000000000000000000000000000000000000000000000000000001502 216.0
HKD1_k127_78887_38 Protein of unknown function (DUF3014) - - - 0.000000000000000000000000000000000000000000000000000006998 199.0
HKD1_k127_78887_39 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000335 194.0
HKD1_k127_78887_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 4.514e-226 706.0
HKD1_k127_78887_40 at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA) K04752 - - 0.000000000000000000000000000000000000000000000000001742 184.0
HKD1_k127_78887_41 Regulatory protein GntR HTH - - - 0.000000000000000000000000000000000000000000000001093 186.0
HKD1_k127_78887_42 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000000000133 178.0
HKD1_k127_78887_43 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000006353 179.0
HKD1_k127_78887_44 - - - - 0.00000000000000000000000000000000000000174 161.0
HKD1_k127_78887_45 synthesis repressor, PhaR - - - 0.0000000000000000000000000000000003996 139.0
HKD1_k127_78887_46 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000007171 141.0
HKD1_k127_78887_47 lactoylglutathione lyase activity K01759,K05606,K08234 - 4.4.1.5,5.1.99.1 0.000000000000000000000000000991 118.0
HKD1_k127_78887_48 Type IV Pilus-assembly protein W K02672 - - 0.0000000000000000002194 102.0
HKD1_k127_78887_49 COG4968 Tfp pilus assembly protein PilE K02655 - - 0.0000000000000000004235 93.0
HKD1_k127_78887_5 Belongs to the TPP enzyme family K01652 - 2.2.1.6 3.974e-210 668.0
HKD1_k127_78887_50 Cytochrome c K00406 - - 0.000000000000000000511 96.0
HKD1_k127_78887_51 Type II transport protein GspH K08084 - - 0.000000000001342 78.0
HKD1_k127_78887_52 PilZ domain - - - 0.000000000007406 69.0
HKD1_k127_78887_54 Poly(R)-hydroxyalkanoic acid synthase subunit - - - 0.0000000008555 69.0
HKD1_k127_78887_55 - - - - 0.00000002081 63.0
HKD1_k127_78887_56 Type IV pilus assembly protein PilX C-term K02673 - - 0.0000006943 58.0
HKD1_k127_78887_57 Prokaryotic N-terminal methylation motif K02671 - - 0.00009655 52.0
HKD1_k127_78887_6 Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process K05797 - 1.17.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003877 619.0
HKD1_k127_78887_7 Acyl-CoA dehydrogenase, middle domain K00253 - 1.3.8.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003509 582.0
HKD1_k127_78887_8 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 565.0
HKD1_k127_78887_9 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006832 509.0
HKD1_k127_7914358_0 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000973 489.0
HKD1_k127_7914358_1 protein involved in response to NO K07234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003728 263.0
HKD1_k127_7914358_2 dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001739 258.0
HKD1_k127_7914358_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000007159 233.0
HKD1_k127_7914358_4 Invasion gene expression up-regulator, SirB - - - 0.000000000000000000000000003472 126.0
HKD1_k127_7914358_5 Protein of unknown function (DUF1761) - - - 0.000000000000000000000000003513 117.0
HKD1_k127_7914358_6 GCN5-related N-acetyl-transferase K06975 - - 0.000000000000000000000001906 105.0
HKD1_k127_7914358_7 Oxidoreductase - - - 0.0000000000000005006 91.0
HKD1_k127_81337_0 ABC-type multidrug transport system, ATPase K06147,K18893 - - 2.584e-308 960.0
HKD1_k127_81337_1 oligopeptide transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 332.0
HKD1_k127_81337_2 MOSC N-terminal beta barrel domain K07140 - - 0.000000000000000000000000000000000000000000000000000006534 198.0
HKD1_k127_81337_3 PFAM SlyX family protein K03745 - - 0.0003851 45.0
HKD1_k127_81591_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1160.0
HKD1_k127_81591_1 response regulator receiver K02487,K06596 - - 2.535e-320 1054.0
HKD1_k127_81591_10 PFAM Type II secretion system protein E K02670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 419.0
HKD1_k127_81591_11 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004182 413.0
HKD1_k127_81591_12 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007789 408.0
HKD1_k127_81591_13 Oxidoreductase FAD-binding domain K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006745 396.0
HKD1_k127_81591_14 chemotaxis protein K02660 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 389.0
HKD1_k127_81591_15 PFAM peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009714 360.0
HKD1_k127_81591_16 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 334.0
HKD1_k127_81591_17 TonB-dependent Receptor Plug K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 342.0
HKD1_k127_81591_18 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 320.0
HKD1_k127_81591_19 COG0209 Ribonucleotide reductase, alpha subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 306.0
HKD1_k127_81591_2 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 8.093e-250 799.0
HKD1_k127_81591_20 Putative aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008707 299.0
HKD1_k127_81591_21 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002395 267.0
HKD1_k127_81591_22 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001713 252.0
HKD1_k127_81591_23 PFAM N-acetylmuramoyl-L-alanine amidase family 2 K03806 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000008319 248.0
HKD1_k127_81591_24 involved in chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000001182 241.0
HKD1_k127_81591_25 adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000009588 229.0
HKD1_k127_81591_26 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000001009 232.0
HKD1_k127_81591_27 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000003525 232.0
HKD1_k127_81591_28 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.0000000000000000000000000000000000000000000000000000000000001446 217.0
HKD1_k127_81591_29 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000001388 218.0
HKD1_k127_81591_3 Molecular chaperone. Has ATPase activity K04079 - - 1.02e-220 701.0
HKD1_k127_81591_30 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000001885 213.0
HKD1_k127_81591_31 response regulator receiver K02657 - - 0.0000000000000000000000000000000000000000000000000000000000192 210.0
HKD1_k127_81591_32 ABC transporter K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000001541 204.0
HKD1_k127_81591_33 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000005278 187.0
HKD1_k127_81591_34 Alpha beta K07018 - - 0.000000000000000000000000000000000000000000000000002189 192.0
HKD1_k127_81591_35 SelR domain - - - 0.00000000000000000000000000000000000000000000000003081 190.0
HKD1_k127_81591_36 Iron--sulfur cluster insertion protein erpA K15724 - - 0.0000000000000000000000000000000000000000000000001434 178.0
HKD1_k127_81591_37 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.4.3.5 0.00000000000000000000000000000000000000000000003638 177.0
HKD1_k127_81591_38 cheY-homologous receiver domain K02658 - - 0.0000000000000000000000000000000000000000001804 161.0
HKD1_k127_81591_39 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000001254 160.0
HKD1_k127_81591_4 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.6.1.62 8.098e-206 649.0
HKD1_k127_81591_40 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000006927 157.0
HKD1_k127_81591_41 integral membrane protein K02221 - - 0.000000000000000000000000000000000002394 143.0
HKD1_k127_81591_42 Type IV pili signal transduction protein PilI K02659 - - 0.0000000000000000000000000000002745 134.0
HKD1_k127_81591_43 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000004352 126.0
HKD1_k127_81591_44 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000004047 125.0
HKD1_k127_81591_45 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000000004807 124.0
HKD1_k127_81591_46 TIGRFAM TonB K03832 - - 0.000000000000000000000000006366 123.0
HKD1_k127_81591_47 Belongs to the bacterial histone-like protein family - - - 0.0000000000000000000000009152 110.0
HKD1_k127_81591_48 Two component signalling adaptor domain K06598 - - 0.00000000000000000002542 101.0
HKD1_k127_81591_49 - - - - 0.00000000000004274 84.0
HKD1_k127_81591_5 Domain of unknown function (DUF4478) K06966 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464,GO:0047405 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006437 603.0
HKD1_k127_81591_50 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0003504 43.0
HKD1_k127_81591_6 twitching motility protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003688 567.0
HKD1_k127_81591_7 twitching motility protein K02670 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 537.0
HKD1_k127_81591_8 Lysin motif K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 490.0
HKD1_k127_81591_9 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009641 453.0
HKD1_k127_896513_0 Nitrite reductase K15864 - 1.7.2.1,1.7.99.1 1.239e-314 981.0
HKD1_k127_896513_1 Heat shock 70 kDa protein K04043 - - 7.906e-199 624.0
HKD1_k127_896513_10 Tannase and feruloyl esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 445.0
HKD1_k127_896513_11 Amidohydrolase K14333,K15063 - 4.1.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000579 427.0
HKD1_k127_896513_12 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 427.0
HKD1_k127_896513_13 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007049 434.0
HKD1_k127_896513_14 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 399.0
HKD1_k127_896513_15 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003036 392.0
HKD1_k127_896513_16 metal-dependent hydrolase of the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 392.0
HKD1_k127_896513_17 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003182 369.0
HKD1_k127_896513_18 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 342.0
HKD1_k127_896513_19 nitrite transmembrane transporter activity K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000617 357.0
HKD1_k127_896513_2 4-oxalomesaconate hydratase K03392,K10220 - 4.1.1.45,4.2.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 551.0
HKD1_k127_896513_20 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006453 338.0
HKD1_k127_896513_21 Trimethylamine methyltransferase (MTTB) K14083 - 2.1.1.250 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 336.0
HKD1_k127_896513_22 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 326.0
HKD1_k127_896513_23 4-carboxy-4-hydroxy-2-oxoadipate aldolase oxaloacetate decarboxylase K10218 - 4.1.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 314.0
HKD1_k127_896513_24 Domain of unknown function (DUF1794) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003089 302.0
HKD1_k127_896513_25 Domain of unknown function (DUF1932) K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 309.0
HKD1_k127_896513_26 Uroporphyrinogen-III synthase HemD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 297.0
HKD1_k127_896513_27 Uncharacterized protein family UPF0016 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 288.0
HKD1_k127_896513_28 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000003639 243.0
HKD1_k127_896513_29 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001602 252.0
HKD1_k127_896513_3 Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate K11103 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009527 512.0
HKD1_k127_896513_30 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000000000000000000000004601 224.0
HKD1_k127_896513_31 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000004672 231.0
HKD1_k127_896513_32 Methionine synthase B12-binding module cap domain protein K00548,K14084 - 2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000003496 227.0
HKD1_k127_896513_33 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000000000000005218 214.0
HKD1_k127_896513_34 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000000000002524 211.0
HKD1_k127_896513_35 COG1956 GAF domain-containing protein K08968 - 1.8.4.14 0.0000000000000000000000000000000000000000000000000000000001713 213.0
HKD1_k127_896513_36 PFAM Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000000000001298 203.0
HKD1_k127_896513_37 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000001231 194.0
HKD1_k127_896513_38 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.000000000000000000000000000000000000000000000000455 179.0
HKD1_k127_896513_39 - - - - 0.000000000000000000000000000000000000000000003783 176.0
HKD1_k127_896513_4 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 494.0
HKD1_k127_896513_40 Putative adhesin - - - 0.000000000000000000000000000000000000001843 158.0
HKD1_k127_896513_41 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000007382 155.0
HKD1_k127_896513_42 membrane - - - 0.00000000000000000000000000000000000002287 148.0
HKD1_k127_896513_43 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000003124 156.0
HKD1_k127_896513_44 Uncharacterized ACR, COG1993 - - - 0.0000000000000000000000000000000000005659 149.0
HKD1_k127_896513_45 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030554,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071840,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000002927 143.0
HKD1_k127_896513_46 Cyclase dehydrase - - - 0.0000000000000000000000000000000000966 139.0
HKD1_k127_896513_47 phosphohistidine phosphatase, SixA K08296 - - 0.00000000000000000000000003471 117.0
HKD1_k127_896513_48 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000006879 91.0
HKD1_k127_896513_49 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.0000000000000002557 84.0
HKD1_k127_896513_5 Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols K04101 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 474.0
HKD1_k127_896513_50 CHAD - - - 0.000000000000003799 87.0
HKD1_k127_896513_51 EF-hand domain pair - - - 0.0000003074 56.0
HKD1_k127_896513_53 Belongs to the UPF0125 (RnfH) family K09801 - - 0.0001569 48.0
HKD1_k127_896513_6 belongs to the aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 475.0
HKD1_k127_896513_7 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 467.0
HKD1_k127_896513_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 441.0
HKD1_k127_896513_9 receptor K16087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 460.0
HKD1_k127_924041_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 491.0
HKD1_k127_924041_1 Transglycosylase K05367 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000009869 240.0
HKD1_k127_924041_2 Twitching motility protein PilT - - - 0.00000000000000000000000003642 111.0
HKD1_k127_924041_3 SpoVT / AbrB like domain - - - 0.0000000000002919 82.0