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Overview

ID MAG01733
Name HKD1_bin.50
Sample SMP0046
Taxonomy
Kingdom Bacteria
Phylum Gemmatimonadota
Class Gemmatimonadetes
Order Gemmatimonadales
Family GWC2-71-9
Genus DASTHG01
Species
Assembly information
Completeness (%) 83.18
Contamination (%) 0.2
GC content (%) 68.0
N50 (bp) 26,260
Genome size (bp) 2,893,088

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2477

Gene name Description KEGG GOs EC E-value Score Sequence
HKD1_k127_1006608_0 Elongation factor G C-terminus K06207 - - 3.219e-262 820.0
HKD1_k127_1006608_1 Peptidase family M1 domain - - - 9.194e-247 781.0
HKD1_k127_1006608_10 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000005479 239.0
HKD1_k127_1006608_11 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000001865 226.0
HKD1_k127_1006608_12 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000005009 213.0
HKD1_k127_1006608_13 Pyridoxal phosphate biosynthetic protein PdxA K00097 - 1.1.1.262 0.000000000000000000000000000000000000000000000000000002339 193.0
HKD1_k127_1006608_14 ferredoxin-NADP+ reductase activity - - - 0.0000000000000000000000000000000001018 146.0
HKD1_k127_1006608_15 Protein of unknown function (DUF456) K09793 - - 0.000000000000000000000000000001694 126.0
HKD1_k127_1006608_16 PAP2 superfamily - - - 0.0000000000000000005222 97.0
HKD1_k127_1006608_2 Asparagine synthase K01953 - 6.3.5.4 1.321e-238 756.0
HKD1_k127_1006608_3 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008035 440.0
HKD1_k127_1006608_4 heat shock protein binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 437.0
HKD1_k127_1006608_5 Transporter associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 396.0
HKD1_k127_1006608_6 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006207 262.0
HKD1_k127_1006608_7 cation diffusion facilitator family transporter K16264 GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - 0.00000000000000000000000000000000000000000000000000000000000000000000000002109 260.0
HKD1_k127_1006608_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002894 265.0
HKD1_k127_1006608_9 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000004106 259.0
HKD1_k127_11448_0 penicillin amidase K01434 - 3.5.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 432.0
HKD1_k127_11448_1 Glycerate kinase family K00865 GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0043798,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0055114,GO:0071704,GO:1901575 2.7.1.165 0.0000000000000000000000000000000000002756 148.0
HKD1_k127_11448_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000004589 139.0
HKD1_k127_1201980_0 Phosphoenolpyruvate carboxylase K01595 - 4.1.1.31 0.0 1033.0
HKD1_k127_1201980_1 ATP-grasp domain K01903,K14067 - 6.2.1.5,6.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 549.0
HKD1_k127_1201980_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902,K08692 - 6.2.1.5,6.2.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 455.0
HKD1_k127_1201980_3 D-isomer specific 2-hydroxyacid dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 402.0
HKD1_k127_1201980_4 aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006173 408.0
HKD1_k127_1201980_5 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003555 387.0
HKD1_k127_1201980_6 Clp protease - - - 0.000000000000000000000000000000000000000000000000000000000000000002722 238.0
HKD1_k127_1201980_7 AAA domain - - - 0.0000000000000000866 87.0
HKD1_k127_1211054_0 DNA ligase (ATP) activity K01971 - 6.5.1.1 2.039e-302 949.0
HKD1_k127_1211054_1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 3.219e-248 780.0
HKD1_k127_1211054_10 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003705 447.0
HKD1_k127_1211054_11 2Fe-2S iron-sulfur cluster binding domain K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002335 442.0
HKD1_k127_1211054_12 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 391.0
HKD1_k127_1211054_13 3' exoribonuclease, RNase T-like K03656,K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004355 409.0
HKD1_k127_1211054_14 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 360.0
HKD1_k127_1211054_15 Heavy metal translocating P-type atpase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 332.0
HKD1_k127_1211054_16 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 323.0
HKD1_k127_1211054_17 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 291.0
HKD1_k127_1211054_18 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002061 288.0
HKD1_k127_1211054_19 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001588 268.0
HKD1_k127_1211054_2 Molybdopterin oxidoreductase K00123 - 1.17.1.9 3.201e-246 770.0
HKD1_k127_1211054_20 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004494 285.0
HKD1_k127_1211054_21 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001718 264.0
HKD1_k127_1211054_22 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001465 247.0
HKD1_k127_1211054_23 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000001837 245.0
HKD1_k127_1211054_24 Cytochrome C biogenesis protein transmembrane region K04084 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000001825 228.0
HKD1_k127_1211054_25 Cytochrome C oxidase, cbb3-type, subunit III K19713 - 1.8.2.2 0.000000000000000000000000000000000000000000000000000000000000005282 231.0
HKD1_k127_1211054_26 extracellular polysaccharide biosynthetic process K13582 - - 0.0000000000000000000000000000000000000000000000000000000000001204 224.0
HKD1_k127_1211054_27 - - - - 0.0000000000000000000000000000000000000000000000000000000000007028 221.0
HKD1_k127_1211054_28 - - - - 0.00000000000000000000000000000000000000000000000000000009002 202.0
HKD1_k127_1211054_29 EVE domain - - - 0.000000000000000000000000000000000000000000000008179 175.0
HKD1_k127_1211054_3 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00122,K00335 - 1.17.1.9,1.6.5.3 6.916e-239 753.0
HKD1_k127_1211054_30 Protein of unknown function, DUF255 K06888 - - 0.00000000000000000000000000000000000000000000003036 189.0
HKD1_k127_1211054_31 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000000000000000000008682 155.0
HKD1_k127_1211054_32 Thioredoxin-like - - - 0.000000000000000000000000000000000002136 154.0
HKD1_k127_1211054_33 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000001974 139.0
HKD1_k127_1211054_34 membrane - - - 0.00000000000000000000000000009937 125.0
HKD1_k127_1211054_35 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0000000000000000000000000001096 117.0
HKD1_k127_1211054_36 Redoxin - - - 0.0000000000000000000000000003894 116.0
HKD1_k127_1211054_37 redox protein regulator of disulfide bond formation K07397 - - 0.000000000000000000000004391 109.0
HKD1_k127_1211054_38 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000002914 109.0
HKD1_k127_1211054_39 PFAM glycoside hydrolase family 13 domain protein - - - 0.000000000000000001099 94.0
HKD1_k127_1211054_4 cellulose binding - - - 2.27e-234 766.0
HKD1_k127_1211054_40 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000002094 92.0
HKD1_k127_1211054_41 Psort location OuterMembrane, score K13735 - - 0.0000000001828 72.0
HKD1_k127_1211054_42 - - - - 0.000000000493 66.0
HKD1_k127_1211054_43 PFAM DoxX family protein K15977 - - 0.00000005642 63.0
HKD1_k127_1211054_44 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.00001671 57.0
HKD1_k127_1211054_45 FAD dependent oxidoreductase K00301 - 1.5.3.1 0.00003149 46.0
HKD1_k127_1211054_46 - - - - 0.00005652 54.0
HKD1_k127_1211054_48 Antioxidant, AhpC TSA family K03564 - 1.11.1.15 0.0001212 48.0
HKD1_k127_1211054_5 Major Facilitator Superfamily - - - 2.152e-222 700.0
HKD1_k127_1211054_6 Aldehyde dehydrogenase family K00294,K13821 - 1.2.1.88,1.5.5.2 1.142e-219 693.0
HKD1_k127_1211054_7 aminopeptidase activity K01301 - 3.4.17.21 1.668e-218 700.0
HKD1_k127_1211054_8 Belongs to the peptidase S1B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008878 537.0
HKD1_k127_1211054_9 PFAM Na dependent nucleoside transporter K03317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 486.0
HKD1_k127_1307882_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 482.0
HKD1_k127_1307882_1 Nucleotidyl transferase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001145 287.0
HKD1_k127_1307882_2 Sugar nucleotidyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005905 262.0
HKD1_k127_1307882_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000003411 165.0
HKD1_k127_1307882_4 Roadblock/LC7 domain K07131 - - 0.000000000000000000000000003705 114.0
HKD1_k127_1307882_5 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000001822 85.0
HKD1_k127_1307882_6 Transcriptional regulatory protein, C terminal K07657 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000007109 91.0
HKD1_k127_1307882_7 - - - - 0.00000000000001281 81.0
HKD1_k127_1427208_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 1.265e-195 619.0
HKD1_k127_1427208_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000342 172.0
HKD1_k127_1427208_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000008389 163.0
HKD1_k127_1427208_3 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000002144 165.0
HKD1_k127_1427208_4 Septum formation initiator K05589 - - 0.000000003866 66.0
HKD1_k127_1445590_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 488.0
HKD1_k127_1445590_1 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000002583 268.0
HKD1_k127_1445590_3 Trypsin-like serine proteases typically periplasmic contain C-terminal PDZ domain K04771 - 3.4.21.107 0.00001827 57.0
HKD1_k127_1459458_0 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 1.155e-239 748.0
HKD1_k127_1459458_1 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 2.257e-235 739.0
HKD1_k127_1459458_10 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000003584 196.0
HKD1_k127_1459458_11 saccharopine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000002353 179.0
HKD1_k127_1459458_12 Lumazine binding domain K00793 - 2.5.1.9 0.00000000000000000000000000000000000000001495 171.0
HKD1_k127_1459458_13 - - - - 0.000000000000000000000000000000000000002986 151.0
HKD1_k127_1459458_14 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.0000000000000000000000000000000005014 149.0
HKD1_k127_1459458_15 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000003375 114.0
HKD1_k127_1459458_16 Regulatory protein, FmdB family - - - 0.00000000000000005034 84.0
HKD1_k127_1459458_17 - - - - 0.00000002925 66.0
HKD1_k127_1459458_18 PAP2 superfamily - - - 0.00005815 53.0
HKD1_k127_1459458_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 596.0
HKD1_k127_1459458_3 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000598 348.0
HKD1_k127_1459458_4 pfkB family carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 363.0
HKD1_k127_1459458_5 AIR synthase related protein, C-terminal domain K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 344.0
HKD1_k127_1459458_6 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 313.0
HKD1_k127_1459458_7 iron ion binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002103 282.0
HKD1_k127_1459458_8 ERAP1-like C-terminal domain K01256 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000006678 200.0
HKD1_k127_1459458_9 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000342 202.0
HKD1_k127_1460734_0 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000004823 177.0
HKD1_k127_1460734_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000005178 67.0
HKD1_k127_1460734_2 Lipase maturation factor - - - 0.000000000301 62.0
HKD1_k127_1465389_0 PFAM TonB-dependent Receptor Plug - - - 9.97e-241 784.0
HKD1_k127_1465389_1 CarboxypepD_reg-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006699 612.0
HKD1_k127_1465389_10 water channel activity K02440,K06188,K09874 - - 0.0000000000000000000000000000000000000000000000000001123 197.0
HKD1_k127_1465389_11 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000003178 183.0
HKD1_k127_1465389_12 Flavin reductase like domain - - - 0.0000000000000000000000000000000000004067 147.0
HKD1_k127_1465389_13 Cytochrome oxidase assembly protein K02259 - - 0.0000000000000000000000000000000000445 145.0
HKD1_k127_1465389_14 - - - - 0.0000000000000000000000000000000003215 140.0
HKD1_k127_1465389_15 Integral membrane protein DUF92 - - - 0.00000000000000000000000000000001656 139.0
HKD1_k127_1465389_16 AAA domain, putative AbiEii toxin, Type IV TA system K02193 - 3.6.3.41 0.0000000000000000000000000000008669 126.0
HKD1_k127_1465389_17 COG2386 ABC-type transport system involved in cytochrome c biogenesis, permease component K02194 - - 0.000000000000000000000000000001825 130.0
HKD1_k127_1465389_18 Predicted permease YjgP/YjgQ family K07091 - - 0.0000000000000000000000000002316 120.0
HKD1_k127_1465389_19 Putative zinc-finger - - - 0.0000000003357 66.0
HKD1_k127_1465389_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005652 571.0
HKD1_k127_1465389_3 PFAM amino acid permease-associated region K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003139 498.0
HKD1_k127_1465389_4 Metallopeptidase family M24 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008523 400.0
HKD1_k127_1465389_5 Starch-binding associating with outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004309 334.0
HKD1_k127_1465389_6 Predicted permease YjgP/YjgQ family K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004822 329.0
HKD1_k127_1465389_7 Glucose inhibited division protein A K21401 - 1.3.99.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006912 301.0
HKD1_k127_1465389_8 Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000001939 231.0
HKD1_k127_1465389_9 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000000006821 198.0
HKD1_k127_1465436_0 Alpha mannosidase, middle domain K01191 - 3.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 533.0
HKD1_k127_1465436_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009311 316.0
HKD1_k127_1465436_10 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.00000000001044 78.0
HKD1_k127_1465436_2 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006086 307.0
HKD1_k127_1465436_3 histidine kinase A domain protein K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006861 319.0
HKD1_k127_1465436_4 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003769 295.0
HKD1_k127_1465436_5 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001736 261.0
HKD1_k127_1465436_6 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000954 253.0
HKD1_k127_1465436_7 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000001761 199.0
HKD1_k127_1465436_8 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000001554 95.0
HKD1_k127_1465436_9 ABC transporter K01990,K21397 - - 0.0000000000000001193 94.0
HKD1_k127_1482309_0 Carbohydrate family 9 binding domain-like - - - 1.663e-308 961.0
HKD1_k127_1482309_1 Pfam Beta-galactosidase trimerisation domain K12308 - 3.2.1.23 2.387e-261 827.0
HKD1_k127_1482309_10 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003208 276.0
HKD1_k127_1482309_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002342 263.0
HKD1_k127_1482309_12 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002517 260.0
HKD1_k127_1482309_13 Regulator of chromosome condensation (RCC1) repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004169 256.0
HKD1_k127_1482309_14 PFAM Asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000002437 233.0
HKD1_k127_1482309_15 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000001471 234.0
HKD1_k127_1482309_16 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide - - - 0.000000000000000000000000000000000000000000000000000000000001673 217.0
HKD1_k127_1482309_17 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000001603 209.0
HKD1_k127_1482309_18 Bacterial transcriptional activator domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000004683 202.0
HKD1_k127_1482309_19 myo-inosose-2 dehydratase activity - - - 0.000000000000000000000000000000000000000000000000000001057 203.0
HKD1_k127_1482309_2 lysine biosynthetic process via aminoadipic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 622.0
HKD1_k127_1482309_20 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000008395 174.0
HKD1_k127_1482309_21 WD40-like Beta Propeller Repeat K03641 - - 0.00000000000000000000000000000000000000001578 171.0
HKD1_k127_1482309_22 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000001651 155.0
HKD1_k127_1482309_23 ECF sigma factor K03088 - - 0.0000000000000000000000000000000009479 141.0
HKD1_k127_1482309_24 - - - - 0.00000000000000000000000000004224 124.0
HKD1_k127_1482309_25 chemotaxis protein K03406 - - 0.00000000000000000000000000005545 134.0
HKD1_k127_1482309_26 S-layer homology domain - - - 0.000000000000000000000000006776 124.0
HKD1_k127_1482309_27 Lysin motif - - - 0.0000000000000000000006028 96.0
HKD1_k127_1482309_28 - - - - 0.000000003032 63.0
HKD1_k127_1482309_29 hydrolase activity, acting on ester bonds - - - 0.00000001557 57.0
HKD1_k127_1482309_3 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 440.0
HKD1_k127_1482309_30 Bacterial Ig-like domain (group 1) - - - 0.00003677 56.0
HKD1_k127_1482309_4 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 445.0
HKD1_k127_1482309_5 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 432.0
HKD1_k127_1482309_6 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 445.0
HKD1_k127_1482309_7 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 353.0
HKD1_k127_1482309_8 Phospholipase D. Active site motifs. K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003459 332.0
HKD1_k127_1482309_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 310.0
HKD1_k127_1580743_0 Carbohydrate family 9 binding domain-like - - - 1.533e-306 963.0
HKD1_k127_1580743_1 Prolyl oligopeptidase family - - - 1.427e-235 750.0
HKD1_k127_1580743_10 Bacterial protein of unknown function (DUF899) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005093 277.0
HKD1_k127_1580743_11 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000002786 233.0
HKD1_k127_1580743_12 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000222 188.0
HKD1_k127_1580743_13 RDD family - - - 0.0000000000000000000000000000000000000495 149.0
HKD1_k127_1580743_14 Domain of unknown function (DUF3597) - - - 0.0000000000000000000000000000000000002834 143.0
HKD1_k127_1580743_15 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.00000000000000000000000000000000009284 139.0
HKD1_k127_1580743_16 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000002761 121.0
HKD1_k127_1580743_17 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000004205 111.0
HKD1_k127_1580743_18 Domain of unknown function (DUF4412) - - - 0.00000002432 64.0
HKD1_k127_1580743_2 Beta-L-arabinofuranosidase, GH127 K09955 - - 6.878e-203 650.0
HKD1_k127_1580743_3 hydrolase activity, hydrolyzing O-glycosyl compounds K00689 GO:0005575,GO:0005576 2.4.1.5 6.996e-198 633.0
HKD1_k127_1580743_4 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 565.0
HKD1_k127_1580743_5 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 529.0
HKD1_k127_1580743_6 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 417.0
HKD1_k127_1580743_7 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 382.0
HKD1_k127_1580743_8 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 340.0
HKD1_k127_1580743_9 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 336.0
HKD1_k127_1607133_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1442.0
HKD1_k127_1607133_1 ligase activity, forming nitrogen-metal bonds K02230 - 6.6.1.2 0.0 1295.0
HKD1_k127_1607133_10 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087,K16055 GO:0003674,GO:0003824,GO:0004805,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0033554,GO:0034637,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044464,GO:0046351,GO:0050896,GO:0051716,GO:0070413,GO:0071704,GO:1901576 2.4.1.15,3.1.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 591.0
HKD1_k127_1607133_11 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 - 2.7.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009377 581.0
HKD1_k127_1607133_12 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005762 580.0
HKD1_k127_1607133_13 AAA domain K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 570.0
HKD1_k127_1607133_14 DALR_2 K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 540.0
HKD1_k127_1607133_15 Domain of unknown function (DUF3536) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005204 514.0
HKD1_k127_1607133_16 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006876 517.0
HKD1_k127_1607133_17 Putative ATP-binding cassette K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 518.0
HKD1_k127_1607133_18 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 499.0
HKD1_k127_1607133_19 Glycoside hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 491.0
HKD1_k127_1607133_2 Carbohydrate phosphorylase K00688 - 2.4.1.1 6.043e-283 885.0
HKD1_k127_1607133_20 Belongs to the glycosyl hydrolase 57 family K03406,K16149 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005294 437.0
HKD1_k127_1607133_21 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 412.0
HKD1_k127_1607133_22 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 398.0
HKD1_k127_1607133_23 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008297 376.0
HKD1_k127_1607133_24 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 342.0
HKD1_k127_1607133_25 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008615 329.0
HKD1_k127_1607133_26 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 340.0
HKD1_k127_1607133_27 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 331.0
HKD1_k127_1607133_28 Sodium/calcium exchanger protein K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005618 318.0
HKD1_k127_1607133_29 COG1055 Na H antiporter NhaD and related arsenite permeases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 312.0
HKD1_k127_1607133_3 Dipeptidyl peptidase IV (DPP IV) K01278 - 3.4.14.5 8.11e-280 882.0
HKD1_k127_1607133_30 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003512 318.0
HKD1_k127_1607133_31 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001463 275.0
HKD1_k127_1607133_32 GTP cyclohydrolase I K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005183 279.0
HKD1_k127_1607133_33 Putative modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001985 281.0
HKD1_k127_1607133_34 PFAM Methionine sulfoxide reductase B K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000001051 239.0
HKD1_k127_1607133_35 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000005135 252.0
HKD1_k127_1607133_36 Yip1 domain - - - 0.00000000000000000000000000000000000000000000000000000000000006705 226.0
HKD1_k127_1607133_37 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000001858 222.0
HKD1_k127_1607133_38 Sigma-70, region 4 K03088 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000217 212.0
HKD1_k127_1607133_39 permease - - - 0.00000000000000000000000000000000000000000000000000000007 213.0
HKD1_k127_1607133_4 COG0433 Predicted ATPase K06915 - - 2.812e-265 833.0
HKD1_k127_1607133_40 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000003281 187.0
HKD1_k127_1607133_41 Phosphoribosyl transferase domain K07101 - - 0.0000000000000000000000000000000000000000000000000228 186.0
HKD1_k127_1607133_42 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000000000000000000003603 170.0
HKD1_k127_1607133_43 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000004714 180.0
HKD1_k127_1607133_44 PFAM transglutaminase domain protein - - - 0.0000000000000000000000000000000001188 151.0
HKD1_k127_1607133_45 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000004393 142.0
HKD1_k127_1607133_46 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000009172 137.0
HKD1_k127_1607133_47 subunit of a heme lyase K02200 - - 0.00000000000000000000000000159 122.0
HKD1_k127_1607133_48 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000002165 114.0
HKD1_k127_1607133_49 ABC transporter K01990 - - 0.00000000000000000000000009534 124.0
HKD1_k127_1607133_5 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.489e-260 822.0
HKD1_k127_1607133_50 Protein of unknown function, DUF485 - - - 0.000000000000000000001678 96.0
HKD1_k127_1607133_51 sensor histidine kinase response - - - 0.000000000000000000005279 105.0
HKD1_k127_1607133_52 - - - - 0.00000000000000000008124 100.0
HKD1_k127_1607133_53 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000004883 86.0
HKD1_k127_1607133_54 Protein of unknown function (DUF721) - - - 0.00000000000000000341 88.0
HKD1_k127_1607133_55 Acid phosphatase homologues - - - 0.000000000000000005255 93.0
HKD1_k127_1607133_56 - - - - 0.0000000000000001149 87.0
HKD1_k127_1607133_57 4-vinyl reductase, 4VR - - - 0.0000000000001282 79.0
HKD1_k127_1607133_59 AraC-like ligand binding domain - - - 0.00000000002806 72.0
HKD1_k127_1607133_6 Amylo-alpha-1,6-glucosidase - - - 1.001e-248 789.0
HKD1_k127_1607133_60 Membrane - - - 0.00000000004823 71.0
HKD1_k127_1607133_61 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.00000000007863 73.0
HKD1_k127_1607133_62 COGs COG2380 conserved - - - 0.00000003507 56.0
HKD1_k127_1607133_63 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000003987 63.0
HKD1_k127_1607133_7 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 1.801e-248 783.0
HKD1_k127_1607133_8 Sodium:solute symporter family K14393 - - 3.239e-242 758.0
HKD1_k127_1607133_9 Pyrimidine nucleoside phosphorylase C-terminal domain K00756 - 2.4.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 611.0
HKD1_k127_1641837_0 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008664 535.0
HKD1_k127_1641837_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000434 501.0
HKD1_k127_1641837_10 Belongs to the carbamate kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000118 254.0
HKD1_k127_1641837_11 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000002288 174.0
HKD1_k127_1641837_12 NDK K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000002091 175.0
HKD1_k127_1641837_13 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000000000000001933 147.0
HKD1_k127_1641837_14 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588,K01945 - 5.4.99.18,6.3.4.13 0.0000000000000000000000000000001176 140.0
HKD1_k127_1641837_15 SNARE associated Golgi protein - - - 0.0000000000000000000000000000002424 140.0
HKD1_k127_1641837_16 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000001465 110.0
HKD1_k127_1641837_17 Ribosomal L32p protein family K02911 - - 0.000000000000000000006889 93.0
HKD1_k127_1641837_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006114 494.0
HKD1_k127_1641837_3 Elongator protein 3, MiaB family, Radical SAM K18285 - 2.5.1.120 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 489.0
HKD1_k127_1641837_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 422.0
HKD1_k127_1641837_5 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 396.0
HKD1_k127_1641837_6 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005585 348.0
HKD1_k127_1641837_7 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 302.0
HKD1_k127_1641837_8 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 294.0
HKD1_k127_1641837_9 Acyl transferase domain K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000007465 284.0
HKD1_k127_1696398_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 2.465e-268 835.0
HKD1_k127_1696398_1 homoserine kinase activity K00823,K07250 - 2.6.1.19,2.6.1.22 4.324e-206 652.0
HKD1_k127_1696398_10 Peptidase C26 K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000007895 247.0
HKD1_k127_1696398_11 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000003713 225.0
HKD1_k127_1696398_12 O-acyltransferase activity K00661,K04042 - 2.3.1.157,2.3.1.79,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000001894 225.0
HKD1_k127_1696398_13 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000000000000000000002428 184.0
HKD1_k127_1696398_14 - - - - 0.00000000000000000000000000000000000000000004411 182.0
HKD1_k127_1696398_15 TonB-dependent Receptor Plug K02014,K16089 - - 0.0000000000000000000000000000000000000002045 173.0
HKD1_k127_1696398_16 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000005366 151.0
HKD1_k127_1696398_17 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.0000000000000000000000000000001316 139.0
HKD1_k127_1696398_18 Lipopolysaccharide-assembly, LptC-related - - - 0.0000000000000000000000000000003242 129.0
HKD1_k127_1696398_19 polysaccharide deacetylase - - - 0.000000000000000005428 98.0
HKD1_k127_1696398_2 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002801 612.0
HKD1_k127_1696398_20 - - - - 0.000004301 56.0
HKD1_k127_1696398_3 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 433.0
HKD1_k127_1696398_4 ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006775 399.0
HKD1_k127_1696398_5 SIS domain K06041 - 5.3.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 372.0
HKD1_k127_1696398_6 Bacterial membrane protein, YfhO - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 360.0
HKD1_k127_1696398_7 DAHP synthetase I family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009534 351.0
HKD1_k127_1696398_8 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 340.0
HKD1_k127_1696398_9 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 316.0
HKD1_k127_1704233_0 asparagine synthase K01953 - 6.3.5.4 6.752e-299 927.0
HKD1_k127_1704233_1 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 1.678e-290 917.0
HKD1_k127_1704233_10 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 489.0
HKD1_k127_1704233_11 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008092 445.0
HKD1_k127_1704233_12 transcriptional regulator K13633 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000713 387.0
HKD1_k127_1704233_13 Threonine dehydratase K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 323.0
HKD1_k127_1704233_14 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003636 286.0
HKD1_k127_1704233_15 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003331 273.0
HKD1_k127_1704233_16 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000211 251.0
HKD1_k127_1704233_17 PFAM Cache K08738 - - 0.000000000000000000000000000000000000000000000000000000000001379 230.0
HKD1_k127_1704233_18 PFAM regulator of chromosome condensation, RCC1 - - - 0.0000000000000000000000000000000000000000000000000000004715 219.0
HKD1_k127_1704233_19 Cupin domain - - - 0.000000000000000000000000000000000000000000000000001351 190.0
HKD1_k127_1704233_2 Domain of unknown function (DUF5117) - - - 1.21e-267 850.0
HKD1_k127_1704233_20 domain protein - - - 0.0000000000000000000000000000000000000000000000001399 181.0
HKD1_k127_1704233_21 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000003535 188.0
HKD1_k127_1704233_22 Single Cache domain 2 K07647 - 2.7.13.3 0.00000000000000000000000000000000000000000001679 181.0
HKD1_k127_1704233_23 DoxX K16937 - 1.8.5.2 0.00000000000000000000000000000000000000000004055 171.0
HKD1_k127_1704233_24 PFAM regulator of chromosome condensation, RCC1 - - - 0.00000000000000000000000000000000000000000009088 178.0
HKD1_k127_1704233_25 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000002748 150.0
HKD1_k127_1704233_26 - - - - 0.0000000000000000000000000000007374 135.0
HKD1_k127_1704233_27 transport - - - 0.00000000000000000000000000004254 123.0
HKD1_k127_1704233_28 MarR family - - - 0.0000000000000000001937 97.0
HKD1_k127_1704233_29 Cupredoxin-like domain - - - 0.000001035 58.0
HKD1_k127_1704233_3 PFAM glycoside hydrolase family 3 domain protein K05349 - 3.2.1.21 3.023e-242 769.0
HKD1_k127_1704233_30 alpha,alpha-trehalase activity K01194 - 3.2.1.28 0.000001225 51.0
HKD1_k127_1704233_31 Protein tyrosine phosphatase activity. It is involved in the biological process described with protein dephosphorylation - GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - 0.00004701 55.0
HKD1_k127_1704233_32 - K14645 - - 0.00006231 55.0
HKD1_k127_1704233_4 oxidoreductase activity K00274 - 1.4.3.4 3.086e-233 732.0
HKD1_k127_1704233_5 - - - - 4.148e-205 662.0
HKD1_k127_1704233_6 inositol 2-dehydrogenase activity - - - 3.006e-202 649.0
HKD1_k127_1704233_7 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 603.0
HKD1_k127_1704233_8 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 581.0
HKD1_k127_1704233_9 Peptidase dimerisation domain K13049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 484.0
HKD1_k127_173331_0 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 1e-323 1013.0
HKD1_k127_173331_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 4.627e-291 908.0
HKD1_k127_173331_10 Protein kinase domain K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000002995 215.0
HKD1_k127_173331_11 Domain of unknown function (DUF4118) K07646 - 2.7.13.3 0.000000000000000000000000000000000000002017 166.0
HKD1_k127_173331_12 Di-haem oxidoreductase, putative peroxidase - - - 0.0000000000005246 72.0
HKD1_k127_173331_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 1.659e-220 698.0
HKD1_k127_173331_3 Divalent cation transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003667 565.0
HKD1_k127_173331_4 Sodium:dicarboxylate symporter family K11102 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004345 465.0
HKD1_k127_173331_5 Protein of unknown function (DUF445) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 424.0
HKD1_k127_173331_6 hydroxymethylglutaryl-CoA reductase (NADPH) activity K00021 - 1.1.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 362.0
HKD1_k127_173331_7 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 339.0
HKD1_k127_173331_8 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003276 290.0
HKD1_k127_173331_9 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000003889 218.0
HKD1_k127_182958_0 Transport of potassium into the cell K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 6.784e-233 737.0
HKD1_k127_182958_1 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 362.0
HKD1_k127_182958_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000001012 160.0
HKD1_k127_182958_11 Polysaccharide deacetylase K22278 - 3.5.1.104 0.000000000000000000000000000000000001716 147.0
HKD1_k127_182958_12 MerR HTH family regulatory protein - - - 0.00000000000000000000000000000000002344 143.0
HKD1_k127_182958_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000001839 122.0
HKD1_k127_182958_14 - - - - 0.0000000000000000000000001273 115.0
HKD1_k127_182958_15 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.000000000000000007124 98.0
HKD1_k127_182958_16 Helix-turn-helix domain - - - 0.00000000002228 74.0
HKD1_k127_182958_17 Tfp pilus assembly protein FimT - - - 0.00001654 53.0
HKD1_k127_182958_19 Tetratricopeptide repeat - - - 0.00004332 56.0
HKD1_k127_182958_2 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 340.0
HKD1_k127_182958_3 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008015 328.0
HKD1_k127_182958_4 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004768 291.0
HKD1_k127_182958_5 Phosphate acyltransferases K00631 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001286 288.0
HKD1_k127_182958_6 metal-dependent phosphohydrolase, HD sub domain K03698 - - 0.00000000000000000000000000000000000000000000000000000000000000002084 238.0
HKD1_k127_182958_7 alginic acid biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000000005046 218.0
HKD1_k127_182958_8 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000001302 189.0
HKD1_k127_182958_9 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000008091 194.0
HKD1_k127_1869894_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1207.0
HKD1_k127_1869894_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K09461 - 1.14.13.40 0.0 1029.0
HKD1_k127_1869894_10 Elongation factor SelB winged helix 3 K03833 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 434.0
HKD1_k127_1869894_11 tryptophan 2,3-dioxygenase activity K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005256 342.0
HKD1_k127_1869894_12 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 342.0
HKD1_k127_1869894_13 Protein of unknown function (DUF1194) K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 333.0
HKD1_k127_1869894_14 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002698 290.0
HKD1_k127_1869894_15 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008614 282.0
HKD1_k127_1869894_16 enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001655 282.0
HKD1_k127_1869894_17 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001376 287.0
HKD1_k127_1869894_18 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000000002205 239.0
HKD1_k127_1869894_19 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000003862 253.0
HKD1_k127_1869894_2 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 6.459e-206 653.0
HKD1_k127_1869894_20 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000004712 241.0
HKD1_k127_1869894_21 FecCD transport family K02013,K02015 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000543 242.0
HKD1_k127_1869894_22 Belongs to the short-chain dehydrogenases reductases (SDR) family K00019,K07535 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.30 0.00000000000000000000000000000000000000000000000000000000004487 222.0
HKD1_k127_1869894_23 von Willebrand factor type A domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000005478 226.0
HKD1_k127_1869894_24 Creatinine amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000007553 196.0
HKD1_k127_1869894_25 PFAM ABC transporter related K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000265 194.0
HKD1_k127_1869894_26 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.000000000000000000000000000000000000000000000001513 186.0
HKD1_k127_1869894_27 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000002312 188.0
HKD1_k127_1869894_28 Oxygen tolerance - - - 0.00000000000000000000000000000000000001374 167.0
HKD1_k127_1869894_29 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000008691 128.0
HKD1_k127_1869894_3 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01667,K01668 - 4.1.99.1,4.1.99.2 3.385e-203 641.0
HKD1_k127_1869894_30 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000004305 128.0
HKD1_k127_1869894_31 protein kinase activity K12132 - 2.7.11.1 0.0000000000000000000000000000005541 139.0
HKD1_k127_1869894_32 endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000005437 116.0
HKD1_k127_1869894_33 protein secretion K21449 - - 0.000000000000000000000001007 110.0
HKD1_k127_1869894_34 Zinc finger domain - - - 0.00000000000002389 84.0
HKD1_k127_1869894_35 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000001806 81.0
HKD1_k127_1869894_36 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000001338 68.0
HKD1_k127_1869894_37 deoxyhypusine monooxygenase activity - - - 0.0000009235 62.0
HKD1_k127_1869894_38 deoxyhypusine monooxygenase activity - - - 0.0002375 54.0
HKD1_k127_1869894_39 Recombinase zinc beta ribbon domain K06400 - - 0.0003196 46.0
HKD1_k127_1869894_4 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 599.0
HKD1_k127_1869894_5 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 525.0
HKD1_k127_1869894_6 cobalamin-transporting ATPase activity K02014,K16092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007366 496.0
HKD1_k127_1869894_7 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 463.0
HKD1_k127_1869894_8 Polysaccharide biosynthesis protein K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005432 464.0
HKD1_k127_1869894_9 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006744 428.0
HKD1_k127_2042296_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1212.0
HKD1_k127_2042296_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533,K17686 - 3.6.3.4,3.6.3.54 3.889e-234 751.0
HKD1_k127_2042296_10 Iron-sulphur cluster biosynthesis - - - 0.0000000000000000000000000000000000005576 142.0
HKD1_k127_2042296_11 BadF/BadG/BcrA/BcrD ATPase family K18676 - 2.7.1.8 0.0000000000000000000000000000000003533 152.0
HKD1_k127_2042296_12 Cupredoxin-like domain - - - 0.000000000000000000000000000000002514 135.0
HKD1_k127_2042296_13 - - - - 0.0000000000000000000008442 98.0
HKD1_k127_2042296_14 Heavy-metal-associated domain K07213 - - 0.0000000000126 67.0
HKD1_k127_2042296_2 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 2.919e-216 693.0
HKD1_k127_2042296_3 Sodium:solute symporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005488 456.0
HKD1_k127_2042296_4 C-terminus of AA_permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 406.0
HKD1_k127_2042296_5 Glycosyl hydrolase family 3 C-terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003586 401.0
HKD1_k127_2042296_6 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000696 343.0
HKD1_k127_2042296_7 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 316.0
HKD1_k127_2042296_8 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000002229 245.0
HKD1_k127_2042296_9 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000006448 154.0
HKD1_k127_2083695_0 aconitate hydratase K01681 - 4.2.1.3 0.0 1309.0
HKD1_k127_2083695_1 Elongation factor G, domain IV K02355 - - 1.129e-268 844.0
HKD1_k127_2083695_10 Protein of unknown function (DUF1800) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 409.0
HKD1_k127_2083695_11 nitrite reductase [NAD(P)H] activity K00158,K00363,K03809,K05710 - 1.2.3.3,1.6.5.2,1.7.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005971 402.0
HKD1_k127_2083695_12 myo-inosose-2 dehydratase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 383.0
HKD1_k127_2083695_13 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005613 376.0
HKD1_k127_2083695_14 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 357.0
HKD1_k127_2083695_15 ATPases associated with a variety of cellular activities K05847 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005956 309.0
HKD1_k127_2083695_16 exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 303.0
HKD1_k127_2083695_17 PFAM Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 305.0
HKD1_k127_2083695_18 mannitol metabolic process K00009,K00041 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009026,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.1.1.17,1.1.1.58 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001284 294.0
HKD1_k127_2083695_19 of the major facilitator superfamily K08151 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000296 279.0
HKD1_k127_2083695_2 glucuronate isomerase K01812 - 5.3.1.12 1.852e-210 662.0
HKD1_k127_2083695_20 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009741 271.0
HKD1_k127_2083695_21 PFAM Binding-protein-dependent transport system inner membrane component K05846 - - 0.000000000000000000000000000000000000000000000000000000000000000000000401 253.0
HKD1_k127_2083695_22 PFAM PfkB domain protein K00874 - 2.7.1.45 0.000000000000000000000000000000000000000000000000000000000000000000005081 254.0
HKD1_k127_2083695_23 Dehydrogenase K00117 - 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000006661 236.0
HKD1_k127_2083695_24 spore germination - - - 0.00000000000000000000000000000000000000000000000000000000000000003738 233.0
HKD1_k127_2083695_25 gluconolactonase activity K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000008306 228.0
HKD1_k127_2083695_26 dimethylhistidine N-methyltransferase activity K18911 - 2.1.1.44 0.0000000000000000000000000000000000000000000000000000000000001318 226.0
HKD1_k127_2083695_27 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000003715 193.0
HKD1_k127_2083695_28 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000003363 184.0
HKD1_k127_2083695_29 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000418 184.0
HKD1_k127_2083695_3 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 614.0
HKD1_k127_2083695_30 - - - - 0.0000000000000000000000000000000000000000000003448 169.0
HKD1_k127_2083695_31 KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000000000000000003596 175.0
HKD1_k127_2083695_32 acetyltransferase - - - 0.000000000000000000000000000000000000000005054 160.0
HKD1_k127_2083695_33 ArsC family - - - 0.0000000000000000000000000000000000000009521 150.0
HKD1_k127_2083695_34 - - - - 0.000000000000000000000000000000002396 137.0
HKD1_k127_2083695_35 Protein of unknown function (DUF692) K09930 - - 0.0000000000000001618 90.0
HKD1_k127_2083695_36 antisigma factor binding K03598 - - 0.00000000000141 78.0
HKD1_k127_2083695_37 Limonene-1,2-epoxide hydrolase catalytic domain K06893 - - 0.000116 54.0
HKD1_k127_2083695_38 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0001577 49.0
HKD1_k127_2083695_4 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 580.0
HKD1_k127_2083695_5 transmembrane transporter activity K08191 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 521.0
HKD1_k127_2083695_6 mannonate dehydratase activity K01686 - 4.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006904 511.0
HKD1_k127_2083695_7 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 499.0
HKD1_k127_2083695_8 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000081 470.0
HKD1_k127_2083695_9 Protein of unknown function (DUF1501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 452.0
HKD1_k127_2176009_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 7.393e-275 866.0
HKD1_k127_2176009_1 Aromatic amino acid lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 526.0
HKD1_k127_2176009_2 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007286 409.0
HKD1_k127_2176009_3 PFAM Amidohydrolase family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 355.0
HKD1_k127_2176009_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001655 291.0
HKD1_k127_2176009_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000000000000001616 213.0
HKD1_k127_2176009_6 Outer membrane lipoprotein - - - 0.000000000000000000001048 98.0
HKD1_k127_2176009_7 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane - - - 0.00000000000000000001001 102.0
HKD1_k127_2176009_8 Polyprenyl synthetase K02523 - 2.5.1.90 0.00000000001849 72.0
HKD1_k127_2202067_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1559.0
HKD1_k127_2202067_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1245.0
HKD1_k127_2202067_10 Oxidoreductase family, NAD-binding Rossmann fold K13018 - 2.3.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005687 315.0
HKD1_k127_2202067_11 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009431 307.0
HKD1_k127_2202067_12 O-acyltransferase activity K13018 - 2.3.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001133 269.0
HKD1_k127_2202067_13 cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000003152 250.0
HKD1_k127_2202067_14 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.000000000000000000000000000000000000000000000000000000000005509 209.0
HKD1_k127_2202067_15 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000003303 208.0
HKD1_k127_2202067_16 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000000000000001871 194.0
HKD1_k127_2202067_17 Polysaccharide biosynthesis protein K15856 - 1.1.1.281 0.0000000000000000000000000000000000000000000000000001106 199.0
HKD1_k127_2202067_18 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000001827 172.0
HKD1_k127_2202067_19 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000000339 152.0
HKD1_k127_2202067_2 UDP binding domain K13015 - 1.1.1.136 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 593.0
HKD1_k127_2202067_20 Outer membrane lipoprotein K05807 - - 0.0000000000000000000000000000000000002555 150.0
HKD1_k127_2202067_21 Ribosomal protein L17 K02879 - - 0.000000000000000000000000000000002711 134.0
HKD1_k127_2202067_22 TPR repeat - - - 0.000000000000000000000000006299 121.0
HKD1_k127_2202067_23 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000002836 98.0
HKD1_k127_2202067_25 Ribosomal protein L36 K02919 - - 0.0000000000001462 71.0
HKD1_k127_2202067_26 RadC-like JAB domain K03630 - - 0.000000007603 59.0
HKD1_k127_2202067_3 UDP binding domain K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 597.0
HKD1_k127_2202067_4 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 501.0
HKD1_k127_2202067_5 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 496.0
HKD1_k127_2202067_6 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 492.0
HKD1_k127_2202067_7 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 467.0
HKD1_k127_2202067_8 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005259 312.0
HKD1_k127_2202067_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 305.0
HKD1_k127_2221169_0 peptidase K01415,K07386 - 3.4.24.71 2.965e-313 973.0
HKD1_k127_2221169_1 Dehydrogenase - - - 5.476e-237 747.0
HKD1_k127_2221169_10 Domain of unknown function (DUF1956) - - - 0.0000000000000000000000000008384 128.0
HKD1_k127_2221169_2 esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006339 576.0
HKD1_k127_2221169_3 pfam abc K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009991 402.0
HKD1_k127_2221169_4 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000902 378.0
HKD1_k127_2221169_5 Creatinine amidohydrolase K01470 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 339.0
HKD1_k127_2221169_6 protein domain associated with - - - 0.00000000000000000000000000000000000000000000000000000000000001035 230.0
HKD1_k127_2221169_7 Biotin-lipoyl like K01993 - - 0.00000000000000000000000000000000000000000000005668 182.0
HKD1_k127_2221169_8 serine threonine protein kinase - - - 0.0000000000000000000000000000000000000002462 156.0
HKD1_k127_2221169_9 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.0000000000000000000000000001611 121.0
HKD1_k127_2244238_0 Sodium:solute symporter family - - - 4.31e-267 836.0
HKD1_k127_2244238_1 PFAM Glycoside hydrolase, family 20, catalytic core K12373 - 3.2.1.52 3.257e-210 677.0
HKD1_k127_2244238_10 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K00857,K01920,K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.21,6.3.2.3,6.3.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 344.0
HKD1_k127_2244238_11 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002126 316.0
HKD1_k127_2244238_12 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 312.0
HKD1_k127_2244238_13 Belongs to the ATCase OTCase family K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0043857,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005319 316.0
HKD1_k127_2244238_14 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 311.0
HKD1_k127_2244238_15 homoserine kinase activity K02204,K13059 - 2.7.1.162,2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003929 309.0
HKD1_k127_2244238_16 Participates in the control of copper homeostasis K06201 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009281 247.0
HKD1_k127_2244238_17 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000198 250.0
HKD1_k127_2244238_18 Peptidase dimerisation domain K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000005861 250.0
HKD1_k127_2244238_19 Nucleotidyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002075 239.0
HKD1_k127_2244238_2 Secreted protein containing N-terminal Zinc-dependent carboxypeptidase related domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 625.0
HKD1_k127_2244238_20 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000007823 232.0
HKD1_k127_2244238_21 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000002288 165.0
HKD1_k127_2244238_22 negative regulation of transcription, DNA-templated - GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000006319 123.0
HKD1_k127_2244238_23 PDZ domain - - - 0.00000000000000000000000001304 123.0
HKD1_k127_2244238_24 Regulates arginine biosynthesis genes K03402 - - 0.000000000000000000000001464 111.0
HKD1_k127_2244238_25 phosphatidate phosphatase activity - - - 0.00000000000000000000001188 115.0
HKD1_k127_2244238_26 Domain of unknown function (DUF1707) - - - 0.00000002939 65.0
HKD1_k127_2244238_3 Alpha-L-fucosidase K01206 - 3.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000376 583.0
HKD1_k127_2244238_4 Phosphoesterase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 524.0
HKD1_k127_2244238_5 Alpha-L-fucosidase K01206 - 3.2.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009264 505.0
HKD1_k127_2244238_6 xanthine dehydrogenase activity K04108 - 1.3.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 471.0
HKD1_k127_2244238_7 Type I phosphodiesterase / nucleotide pyrophosphatase K01113 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 428.0
HKD1_k127_2244238_8 Arginosuccinate synthase K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 410.0
HKD1_k127_2244238_9 cellular manganese ion homeostasis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 398.0
HKD1_k127_2369483_0 Protein of unknown function (DUF1298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 393.0
HKD1_k127_2369483_1 Protein of unknown function (DUF2950) - - - 0.000000000000000000000000000000000000000000000000000000000000000000008189 247.0
HKD1_k127_2369483_2 Protein of unknown function (DUF3300) - - - 0.0000000000000000000000000000000000000001415 165.0
HKD1_k127_2369483_3 protein conserved in bacteria K09898 - - 0.00000000000007856 80.0
HKD1_k127_2369483_4 Enoyl-(Acyl carrier protein) reductase - - - 0.000000001723 62.0
HKD1_k127_2369483_5 PFAM beta-lactamase domain protein - - - 0.00002264 56.0
HKD1_k127_2461344_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.502e-248 778.0
HKD1_k127_2461344_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009564 419.0
HKD1_k127_2461344_2 Phosphoribosyl transferase domain K07100 - - 0.00000000000000000000000000000000000000000000000000007818 200.0
HKD1_k127_2461344_3 BON domain - - - 0.000000000001222 76.0
HKD1_k127_2461344_4 Belongs to the universal stress protein A family - - - 0.00000000001943 74.0
HKD1_k127_246986_0 DEAD DEAH box helicase K03724 - - 0.0 1629.0
HKD1_k127_246986_1 ASPIC and UnbV - - - 0.0 1394.0
HKD1_k127_246986_10 electron transport chain K00347,K03614 - 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 570.0
HKD1_k127_246986_11 LytB protein K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003587 539.0
HKD1_k127_246986_12 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety K21572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 517.0
HKD1_k127_246986_13 peptidase K01415,K07386 - 3.4.24.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 524.0
HKD1_k127_246986_14 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 452.0
HKD1_k127_246986_15 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001952 452.0
HKD1_k127_246986_16 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 416.0
HKD1_k127_246986_17 Organic Anion Transporter Polypeptide (OATP) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005001 415.0
HKD1_k127_246986_18 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001919 421.0
HKD1_k127_246986_19 DNA restriction-modification system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004566 410.0
HKD1_k127_246986_2 AcrB/AcrD/AcrF family - - - 0.0 1270.0
HKD1_k127_246986_20 aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 385.0
HKD1_k127_246986_21 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 347.0
HKD1_k127_246986_22 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003874 342.0
HKD1_k127_246986_23 electron transport chain K00347,K03614,K21163 - 1.6.5.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 307.0
HKD1_k127_246986_24 Glycosyl transferase family 21 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 300.0
HKD1_k127_246986_25 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006428 291.0
HKD1_k127_246986_26 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001746 281.0
HKD1_k127_246986_27 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006791 282.0
HKD1_k127_246986_28 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008341 271.0
HKD1_k127_246986_29 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004348 257.0
HKD1_k127_246986_3 TonB dependent receptor - - - 2.5e-323 1019.0
HKD1_k127_246986_30 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002403 258.0
HKD1_k127_246986_31 FES K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005494 262.0
HKD1_k127_246986_32 Helix-turn-helix diphteria tox regulatory element K03709 - - 0.0000000000000000000000000000000000000000000000000000000000000000000546 239.0
HKD1_k127_246986_33 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000000000000000000000000000000000000000000007334 232.0
HKD1_k127_246986_34 amino acid K03294,K13868 - - 0.0000000000000000000000000000000000000000000000000000000000008514 226.0
HKD1_k127_246986_35 impB/mucB/samB family K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000003509 214.0
HKD1_k127_246986_36 3-hydroxyacyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000001781 214.0
HKD1_k127_246986_37 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.0000000000000000000000000000000000000000000000000000005664 204.0
HKD1_k127_246986_38 thiolester hydrolase activity K01179,K06889,K10773,K15853 - 3.2.1.4,4.2.99.18 0.0000000000000000000000000000000000000000000000000001668 196.0
HKD1_k127_246986_39 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000006588 196.0
HKD1_k127_246986_4 Atp-dependent helicase - - - 6.921e-318 994.0
HKD1_k127_246986_40 Permease MlaE K02066 - - 0.000000000000000000000000000000000000000000000000003091 196.0
HKD1_k127_246986_41 HAD-hyrolase-like K06019 - 3.6.1.1 0.000000000000000000000000000000000000000000000000008869 189.0
HKD1_k127_246986_42 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000006599 189.0
HKD1_k127_246986_43 PFAM Inosine uridine-preferring nucleoside hydrolase K01250 - - 0.0000000000000000000000000000000000000000000000002268 188.0
HKD1_k127_246986_44 Sigma-70 region 2 K03088 - - 0.0000000000000000000000000000000000000000000000003057 198.0
HKD1_k127_246986_45 Universal stress protein family - - - 0.0000000000000000000000000000000000000000000000003837 188.0
HKD1_k127_246986_46 - - - - 0.000000000000000000000000000000000000000000007496 172.0
HKD1_k127_246986_47 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000004683 166.0
HKD1_k127_246986_48 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000002062 172.0
HKD1_k127_246986_49 SNF2 family N-terminal domain - - - 0.0000000000000000000000000000000000000002138 173.0
HKD1_k127_246986_5 cation efflux system protein (Heavy metal efflux pump) - - - 1.792e-282 903.0
HKD1_k127_246986_50 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000003466 168.0
HKD1_k127_246986_51 acr, cog1993 K09137 - - 0.00000000000000000000000000000000000001788 148.0
HKD1_k127_246986_52 NUDIX domain - - - 0.0000000000000000000000000000000000008014 148.0
HKD1_k127_246986_53 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K00558,K07457,K10773 - 2.1.1.37,4.2.99.18 0.000000000000000000000000000000000005094 148.0
HKD1_k127_246986_54 peptidase K07386 - - 0.000000000000000000000000000000000005507 141.0
HKD1_k127_246986_55 - K01992,K19341 - - 0.00000000000000000000000000000000008324 150.0
HKD1_k127_246986_56 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.0000000000000000000000001772 111.0
HKD1_k127_246986_57 Putative adhesin - - - 0.000000000000000000000008953 112.0
HKD1_k127_246986_58 conserved protein (DUF2203) - - - 0.0000000000000000000000418 106.0
HKD1_k127_246986_59 Thioesterase superfamily K07107 - - 0.00000000000000000000009521 103.0
HKD1_k127_246986_6 DNA-directed DNA polymerase K02337,K14162 - 2.7.7.7 6.293e-256 824.0
HKD1_k127_246986_60 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000002189 109.0
HKD1_k127_246986_61 Fibronectin type 3 domain - - - 0.000000000000000000001102 112.0
HKD1_k127_246986_62 chemotaxis protein K03406 - - 0.000000000000000000002348 110.0
HKD1_k127_246986_63 cell redox homeostasis - - - 0.0000000000000000003831 103.0
HKD1_k127_246986_64 Patatin-like phospholipase K07001 - - 0.000000000000000002182 98.0
HKD1_k127_246986_65 PFAM phosphoesterase PA-phosphatase related K19302 - 3.6.1.27 0.00000000000000009835 91.0
HKD1_k127_246986_66 Putative beta-lactamase-inhibitor-like, PepSY-like - - - 0.0000000000000002916 85.0
HKD1_k127_246986_68 - - - - 0.0000000000000005664 90.0
HKD1_k127_246986_69 bacterial-type flagellum-dependent cell motility - - - 0.000000000000003205 90.0
HKD1_k127_246986_7 lysine biosynthetic process via aminoadipic acid - - - 1.012e-238 771.0
HKD1_k127_246986_70 Putative phosphatase (DUF442) - - - 0.000000000003223 74.0
HKD1_k127_246986_71 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.00000000001128 76.0
HKD1_k127_246986_72 Rdx family K07401 - - 0.000000001218 61.0
HKD1_k127_246986_74 Sigma-54 interaction domain - GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.00000001402 61.0
HKD1_k127_246986_75 - - - - 0.00000006743 63.0
HKD1_k127_246986_76 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.00000174 51.0
HKD1_k127_246986_77 SnoaL-like domain - - - 0.000007465 55.0
HKD1_k127_246986_78 Kelch repeat-containing protein - - - 0.00001614 57.0
HKD1_k127_246986_79 Gram-negative bacterial TonB protein C-terminal - - - 0.00003581 56.0
HKD1_k127_246986_8 NAD synthase K01916 - 6.3.1.5 5.004e-211 671.0
HKD1_k127_246986_80 cell adhesion involved in biofilm formation - - - 0.0001356 54.0
HKD1_k127_246986_9 H( )-stimulated, divalent metal cation uptake system K03322 - - 2.718e-208 656.0
HKD1_k127_2478596_0 FtsX-like permease family K02004 - - 1.944e-265 846.0
HKD1_k127_2478596_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009656 576.0
HKD1_k127_2478596_10 O-acyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000227 239.0
HKD1_k127_2478596_11 Histidine kinase K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000001235 223.0
HKD1_k127_2478596_12 Histidine kinase K02484 - 2.7.13.3 0.000000000000000000000000000000000000000000002845 181.0
HKD1_k127_2478596_13 Cytochrome C oxidase subunit II, periplasmic domain K02275 - 1.9.3.1 0.00000000000000000000000000000000000001649 151.0
HKD1_k127_2478596_14 ATP-grasp domain - - - 0.0000000000000000000000000000000003145 139.0
HKD1_k127_2478596_15 Belongs to the universal stress protein A family - - - 0.0000000000006688 80.0
HKD1_k127_2478596_16 nitric oxide dioxygenase activity - - - 0.00000000001525 77.0
HKD1_k127_2478596_17 translation release factor activity K03265 - - 0.0000002296 59.0
HKD1_k127_2478596_2 COG0843 Heme copper-type cytochrome quinol oxidases, subunit 1 K02274 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003007 508.0
HKD1_k127_2478596_3 E1-E2 ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 467.0
HKD1_k127_2478596_4 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 340.0
HKD1_k127_2478596_5 HlyD family secretion protein K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007086 304.0
HKD1_k127_2478596_6 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003357 286.0
HKD1_k127_2478596_7 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008457 254.0
HKD1_k127_2478596_8 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003283 253.0
HKD1_k127_2478596_9 Helix-hairpin-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001928 254.0
HKD1_k127_2483837_0 DHH family K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 503.0
HKD1_k127_2483837_1 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009003 510.0
HKD1_k127_2483837_10 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 - - 0.00000000000000000000000000000000000000000000000000000000000000000002358 237.0
HKD1_k127_2483837_11 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000001079 215.0
HKD1_k127_2483837_12 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000000000000000444 171.0
HKD1_k127_2483837_13 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.00000000000000000000000000000000000000000008339 176.0
HKD1_k127_2483837_14 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000000000000000000000000000001285 162.0
HKD1_k127_2483837_15 STAS domain K04749 - - 0.00000000000000000000000000000000000002318 154.0
HKD1_k127_2483837_16 Zn-ribbon protein possibly nucleic acid-binding K07164 - - 0.0000000000000000000006978 108.0
HKD1_k127_2483837_17 Histidine kinase-like ATPase domain - - - 0.000000000000000000006757 102.0
HKD1_k127_2483837_18 Ribosomal protein L35 K02916 - - 0.0000000001744 63.0
HKD1_k127_2483837_19 - - - - 0.000186 48.0
HKD1_k127_2483837_2 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 375.0
HKD1_k127_2483837_3 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 386.0
HKD1_k127_2483837_4 Aminoacyl tRNA synthetase class II, N-terminal domain K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 355.0
HKD1_k127_2483837_5 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002774 340.0
HKD1_k127_2483837_6 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008667 331.0
HKD1_k127_2483837_7 Arginine deiminase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005075 285.0
HKD1_k127_2483837_8 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000004456 272.0
HKD1_k127_2483837_9 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000000000000000000000001742 246.0
HKD1_k127_2489391_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008724 591.0
HKD1_k127_2489391_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 544.0
HKD1_k127_2489391_10 Protein of unknown function (DUF1697) - - - 0.000000000000000000000000000000000000000000000000001965 196.0
HKD1_k127_2489391_11 PFAM Pyruvate ferredoxin flavodoxin oxidoreductase K00177 - 1.2.7.3 0.00000000000000000000000000000000001933 143.0
HKD1_k127_2489391_12 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000001632 57.0
HKD1_k127_2489391_2 COG0493 NADPH-dependent glutamate synthase beta chain and related K00266,K17722 - 1.3.1.1,1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 502.0
HKD1_k127_2489391_3 LVIVD repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 482.0
HKD1_k127_2489391_4 ferredoxin oxidoreductase, subunit alpha K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004332 358.0
HKD1_k127_2489391_5 Oxidoreductase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 336.0
HKD1_k127_2489391_6 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K02564 - 3.5.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 308.0
HKD1_k127_2489391_7 Best Blastp hit gi 6685602 sp Q57957 KORB_METJA 2-OXOGLUTARATE SYNTHASE SUBUNIT KORB (2-KETOGLUTARATE OXIDOREDUCTASE BETA CHAIN) (KOR) (2-OXOGLUTARATE-FERREDOXIN OXIDOREDUCTASE BETA SUBUNIT) gi 2129229 pir A64367 pyruvate synthase (EC 1.2.7.1) beta chain - Methanococcus jannaschii gi 1591241 gb AAB98531.1 '(U67503) 2-ketoglutarate ferredoxin oxidoreductase, subunit beta (korB) Methanococcus jannaschii ', score K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 302.0
HKD1_k127_2489391_8 FMN reductase (NADPH) activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000876 297.0
HKD1_k127_2489391_9 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003717 286.0
HKD1_k127_2508847_0 Luciferase-like monooxygenase K04091,K17228 - 1.14.14.35,1.14.14.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 519.0
HKD1_k127_2508847_1 RimK-like ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003376 418.0
HKD1_k127_2508847_10 Ppx/GppA phosphatase family - - - 0.000000000000000000000000004716 118.0
HKD1_k127_2508847_11 NADPH-dependent FMN reductase K00299 - 1.5.1.38 0.00000000000000000000000007843 114.0
HKD1_k127_2508847_12 DNA excision K02806 - - 0.00000000000000007545 85.0
HKD1_k127_2508847_13 efflux transmembrane transporter activity - - - 0.00000000000007886 72.0
HKD1_k127_2508847_2 ATPase associated with various cellular K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003711 407.0
HKD1_k127_2508847_3 Di- and tricarboxylate transporters - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006227 333.0
HKD1_k127_2508847_4 Phosphate-selective porin O and P K07221 - - 0.0000000000000000000000000000000000000000000000000000000000000000009101 243.0
HKD1_k127_2508847_5 BlaR1 peptidase M56 - - - 0.00000000000000000000000000000000000000000000000000000001911 211.0
HKD1_k127_2508847_6 triphosphatase activity K01768 GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0050355 4.6.1.1 0.000000000000000000000000000000000000000000000000001577 191.0
HKD1_k127_2508847_7 sulfuric ester hydrolase activity K03760,K06349,K19353 GO:0008150,GO:0022603,GO:0042173,GO:0043937,GO:0043938,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0065007 2.7.8.43 0.000000000000000000000000000000000000000000000001331 184.0
HKD1_k127_2508847_8 - - - - 0.000000000000000000000000000000000000005244 160.0
HKD1_k127_2508847_9 Penicillinase repressor - - - 0.000000000000000000000000000000000004632 140.0
HKD1_k127_2511513_0 Belongs to the ClpA ClpB family K03696 GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - 5.649e-308 965.0
HKD1_k127_2511513_1 Surface antigen K07277 - - 4.86e-229 737.0
HKD1_k127_2511513_10 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 335.0
HKD1_k127_2511513_11 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 309.0
HKD1_k127_2511513_12 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002528 287.0
HKD1_k127_2511513_13 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000000000000435 238.0
HKD1_k127_2511513_14 Bacillithiol biosynthesis BshC K22136 - - 0.0000000000000000000000000000000000000000000000000000000003739 223.0
HKD1_k127_2511513_15 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000006608 179.0
HKD1_k127_2511513_16 UvrB/uvrC motif K19411 - - 0.0000000000000000000000000000000000000000000002235 179.0
HKD1_k127_2511513_17 AMMECR1 K09141 - - 0.0000000000000000000000000000000000000000000009403 172.0
HKD1_k127_2511513_18 Domain of unknown function (DUF374) K09778 - - 0.00000000000000000000000000000000000000005134 160.0
HKD1_k127_2511513_19 - - - - 0.0000000000000000000000000000004335 131.0
HKD1_k127_2511513_2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 7.255e-216 678.0
HKD1_k127_2511513_20 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000000000003466 126.0
HKD1_k127_2511513_21 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000003728 104.0
HKD1_k127_2511513_22 Outer membrane protein (OmpH-like) K06142 - - 0.00000000000000006625 91.0
HKD1_k127_2511513_3 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003897 533.0
HKD1_k127_2511513_4 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007249 498.0
HKD1_k127_2511513_5 ATP:guanido phosphotransferase, C-terminal catalytic domain K19405 - 2.7.14.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 439.0
HKD1_k127_2511513_6 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 406.0
HKD1_k127_2511513_7 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 381.0
HKD1_k127_2511513_8 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006152 334.0
HKD1_k127_2511513_9 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 336.0
HKD1_k127_2545154_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 4.342e-255 793.0
HKD1_k127_2545154_1 Phosphoglycerate kinase K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 507.0
HKD1_k127_2545154_10 Telomere recombination K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000000002263 209.0
HKD1_k127_2545154_11 - K01992 - - 0.000000000000000000000000000000000000000000000000166 203.0
HKD1_k127_2545154_12 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.00000000000000000000000000000000000000000000003903 171.0
HKD1_k127_2545154_13 Low molecular weight phosphatase family K01104 - 3.1.3.48 0.0000000000000000000000000000000000000003521 156.0
HKD1_k127_2545154_14 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000007742 158.0
HKD1_k127_2545154_15 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03635,K21142 - 2.8.1.12 0.000000000000000000000000000008172 124.0
HKD1_k127_2545154_16 PFAM Phosphoribosyltransferase - - - 0.0000000000000000000000000007938 128.0
HKD1_k127_2545154_17 Preprotein translocase SecG subunit K03075 - - 0.0000000000000000000005522 104.0
HKD1_k127_2545154_18 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.00000005426 58.0
HKD1_k127_2545154_19 Domain of unknown function (DUF4340) - - - 0.00008344 54.0
HKD1_k127_2545154_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 481.0
HKD1_k127_2545154_3 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007296 477.0
HKD1_k127_2545154_4 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001362 478.0
HKD1_k127_2545154_5 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 413.0
HKD1_k127_2545154_6 4Fe-4S ferredoxin iron-sulfur binding domain protein K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 386.0
HKD1_k127_2545154_7 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000128 306.0
HKD1_k127_2545154_8 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000007152 259.0
HKD1_k127_2545154_9 protease with the C-terminal PDZ domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000003781 256.0
HKD1_k127_2570966_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 7.723e-216 675.0
HKD1_k127_2570966_1 Beta-eliminating lyase K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 575.0
HKD1_k127_2570966_10 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.00000000000000000000000000000000000000001177 162.0
HKD1_k127_2570966_11 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000000134 139.0
HKD1_k127_2570966_12 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - 0.0000000000000000000000003521 117.0
HKD1_k127_2570966_14 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000000001141 79.0
HKD1_k127_2570966_16 - - - - 0.000008902 55.0
HKD1_k127_2570966_2 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 453.0
HKD1_k127_2570966_3 Zinc-binding dehydrogenase K00060 - 1.1.1.103 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 447.0
HKD1_k127_2570966_4 RDD family K06384 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 338.0
HKD1_k127_2570966_5 associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009283 324.0
HKD1_k127_2570966_6 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007207 263.0
HKD1_k127_2570966_7 Peptidase family M50 - - - 0.000000000000000000000000000000000000000000000000000000000000002376 232.0
HKD1_k127_2570966_8 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000001518 200.0
HKD1_k127_2570966_9 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.0000000000000000000000000000000000000000004066 162.0
HKD1_k127_2632174_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 563.0
HKD1_k127_2632174_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 538.0
HKD1_k127_2632174_2 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01007,K08483 - 2.7.3.9,2.7.9.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003547 396.0
HKD1_k127_2632174_3 PTS system mannose/fructose/sorbose family IID component K02796 - - 0.0000000000000000000000000000000000000000000000000004704 192.0
HKD1_k127_2632174_4 Periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000001659 186.0
HKD1_k127_2632174_5 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000000000003333 179.0
HKD1_k127_2632174_6 Cytochrome c - - - 0.000000000000000000000000000000169 136.0
HKD1_k127_2632174_7 PTS HPr component phosphorylation site K11189 - - 0.000000000000000000002688 104.0
HKD1_k127_2678303_0 tail specific protease K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006938 482.0
HKD1_k127_2678303_1 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005501 464.0
HKD1_k127_2678303_10 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.000000000000000000005797 107.0
HKD1_k127_2678303_11 Belongs to the peptidase S8 family - - - 0.000000000000000000322 101.0
HKD1_k127_2678303_2 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 443.0
HKD1_k127_2678303_3 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004468 272.0
HKD1_k127_2678303_4 Methyltransferase small domain K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000006562 214.0
HKD1_k127_2678303_5 PFAM NADP oxidoreductase coenzyme F420-dependent - - - 0.0000000000000000000000000000000000000000000006611 178.0
HKD1_k127_2678303_6 - - - - 0.0000000000000000000000000000000000000000004367 175.0
HKD1_k127_2678303_7 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000003419 150.0
HKD1_k127_2678303_8 Binds the 23S rRNA K02909 - - 0.0000000000000000000000008835 106.0
HKD1_k127_2678303_9 Control of competence regulator ComK, YlbF/YmcA - - - 0.000000000000000000000001101 108.0
HKD1_k127_2690800_0 PFAM Protein phosphatase 2C K20074 - 3.1.3.16 0.00000000000000000000000000000000000000003528 163.0
HKD1_k127_2690937_0 Carboxypeptidase regulatory-like domain - - - 2.199e-297 960.0
HKD1_k127_2690937_1 Fumarate reductase flavoprotein C-term K00239 - 1.3.5.1,1.3.5.4 2.797e-291 906.0
HKD1_k127_2690937_10 response to heat K03695,K03696,K03697,K03798 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002914 357.0
HKD1_k127_2690937_11 Leucine carboxyl methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003487 320.0
HKD1_k127_2690937_12 Adenosine/AMP deaminase K01488 - 3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 329.0
HKD1_k127_2690937_13 HAMP domain K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005555 323.0
HKD1_k127_2690937_14 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007515 304.0
HKD1_k127_2690937_15 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 289.0
HKD1_k127_2690937_16 Transcriptional regulatory protein, C terminal K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000349 290.0
HKD1_k127_2690937_17 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003506 282.0
HKD1_k127_2690937_18 Glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000008651 237.0
HKD1_k127_2690937_19 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000000000000000000000000000000000000000000000000000000001197 228.0
HKD1_k127_2690937_2 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 6.68e-232 739.0
HKD1_k127_2690937_20 - - - - 0.000000000000000000000000000000000000000000000000000000009392 209.0
HKD1_k127_2690937_21 DinB family - - - 0.00000000000000000000000000000000000000000000000000000007969 209.0
HKD1_k127_2690937_22 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000001793 201.0
HKD1_k127_2690937_23 Zn peptidase - - - 0.000000000000000000000000000000000000000000000000003683 199.0
HKD1_k127_2690937_24 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.00000000000000000000000000000000000000000000001226 191.0
HKD1_k127_2690937_25 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000004403 159.0
HKD1_k127_2690937_26 - - - - 0.000000000000000000000000000000000000000009004 164.0
HKD1_k127_2690937_27 PFAM CHAD domain containing protein - - - 0.0000000000000000000000000000000000000008318 164.0
HKD1_k127_2690937_28 Phosphoglycerate mutase family K08296 - - 0.000000000000000000000000000000004021 140.0
HKD1_k127_2690937_29 - - - - 0.000000000000000000000000000001206 135.0
HKD1_k127_2690937_3 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 5.343e-218 691.0
HKD1_k127_2690937_30 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000001006 99.0
HKD1_k127_2690937_31 Sulfatase - - - 0.0000000000000000003821 98.0
HKD1_k127_2690937_32 PAP2 superfamily K19302 - 3.6.1.27 0.00000000000001102 86.0
HKD1_k127_2690937_33 transcriptional regulator - - - 0.000000000006823 71.0
HKD1_k127_2690937_4 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 6.355e-196 648.0
HKD1_k127_2690937_5 DNA polymerase X family K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 602.0
HKD1_k127_2690937_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008506 421.0
HKD1_k127_2690937_7 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 398.0
HKD1_k127_2690937_8 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 385.0
HKD1_k127_2690937_9 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 386.0
HKD1_k127_2718065_0 PQQ enzyme repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 581.0
HKD1_k127_2718065_1 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000000000001013 225.0
HKD1_k127_2718065_10 - - - - 0.000000000301 72.0
HKD1_k127_2718065_11 - - - - 0.0001734 48.0
HKD1_k127_2718065_2 curli production assembly transport component CsgG K04087 - - 0.00000000000000000000000000000000000000000000001754 188.0
HKD1_k127_2718065_3 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.0000000000000000000000000000000000000000000002075 184.0
HKD1_k127_2718065_4 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000453 181.0
HKD1_k127_2718065_5 Prolyl oligopeptidase family K06889 - - 0.0000000000000000000000000000000000009211 153.0
HKD1_k127_2718065_6 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.00000000000000000000000000002751 118.0
HKD1_k127_2718065_7 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000000000007058 114.0
HKD1_k127_2718065_8 - - - - 0.00000000000000000000002633 106.0
HKD1_k127_2718065_9 Peptidase S24-like K03100 - 3.4.21.89 0.0000000000000256 74.0
HKD1_k127_2896843_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 575.0
HKD1_k127_2896843_1 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004174 321.0
HKD1_k127_2896843_2 BON domain - - - 0.000000223 61.0
HKD1_k127_2896843_3 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00001479 50.0
HKD1_k127_2896843_4 - - - - 0.0002773 49.0
HKD1_k127_2905200_0 WD40-like Beta Propeller Repeat - - - 1.551e-233 758.0
HKD1_k127_2905200_1 amino acid K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 490.0
HKD1_k127_2905200_2 Belongs to the malate synthase family K01638 - 2.3.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 365.0
HKD1_k127_2905200_3 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000009371 174.0
HKD1_k127_2905200_4 - - - - 0.000000000000000000000000000000000000000000008032 171.0
HKD1_k127_2905200_5 Integrase core domain - - - 0.0000000000000000000000000000000000000000001016 165.0
HKD1_k127_2905200_6 DNA-templated transcription, initiation - - - 0.0000000000000000000000000000000000000000004952 172.0
HKD1_k127_2927544_0 Integrase core domain - - - 1.024e-221 699.0
HKD1_k127_3004198_0 PAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 411.0
HKD1_k127_3004198_1 Amylo-alpha-1,6-glucosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 418.0
HKD1_k127_3004198_10 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000005067 217.0
HKD1_k127_3004198_11 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000001876 195.0
HKD1_k127_3004198_12 Protein of unknown function, DUF - - - 0.00000000000000000000000000000000000000007899 157.0
HKD1_k127_3004198_13 Poly(hydroxyalcanoate) granule associated protein (phasin) - - - 0.0000000000009912 79.0
HKD1_k127_3004198_14 PHB/PHA accumulation regulator DNA-binding domain - - - 0.00000000004341 72.0
HKD1_k127_3004198_15 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000005043 60.0
HKD1_k127_3004198_16 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000003172 57.0
HKD1_k127_3004198_17 Gram-negative bacterial TonB protein C-terminal - - - 0.0002323 52.0
HKD1_k127_3004198_2 esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 392.0
HKD1_k127_3004198_3 Belongs to the ABC transporter superfamily K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 363.0
HKD1_k127_3004198_4 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 350.0
HKD1_k127_3004198_5 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 316.0
HKD1_k127_3004198_6 Transcriptional regulatory protein, C terminal K02483,K07665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 320.0
HKD1_k127_3004198_7 MotA/TolQ/ExbB proton channel family K03562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 314.0
HKD1_k127_3004198_8 glycerophosphodiester transmembrane transport K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002947 266.0
HKD1_k127_3004198_9 PFAM binding-protein-dependent transport systems inner membrane component K02025,K17242 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002259 270.0
HKD1_k127_3069119_0 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 600.0
HKD1_k127_3069119_1 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004898 580.0
HKD1_k127_3069119_2 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 465.0
HKD1_k127_3088777_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 1.256e-220 709.0
HKD1_k127_3088777_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 580.0
HKD1_k127_3088777_10 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000004029 246.0
HKD1_k127_3088777_11 - - - - 0.0000000000000000000000000000000000000000000001183 183.0
HKD1_k127_3088777_12 Fimbrial assembly protein (PilN) - - - 0.000000000000000000000000000000000004415 154.0
HKD1_k127_3088777_13 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000000008978 126.0
HKD1_k127_3088777_14 Prokaryotic N-terminal methylation motif K02456,K02650,K02655 - - 0.000000000000000000000001782 106.0
HKD1_k127_3088777_15 - - - - 0.000000000000000000000006605 106.0
HKD1_k127_3088777_16 Pilus assembly protein, PilO K02664 - - 0.0000000000000000000007485 104.0
HKD1_k127_3088777_17 - - - - 0.00000000000000000001727 104.0
HKD1_k127_3088777_18 - - - - 0.0000000000000002453 91.0
HKD1_k127_3088777_19 - - - - 0.000000000002642 78.0
HKD1_k127_3088777_2 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006644 551.0
HKD1_k127_3088777_20 Pilus assembly protein PilX K02673 - - 0.0000000006823 72.0
HKD1_k127_3088777_21 Acyl-ACP thioesterase K07107 - - 0.00000001622 67.0
HKD1_k127_3088777_22 Type IV Pilus-assembly protein W K02672 - - 0.0001295 54.0
HKD1_k127_3088777_3 AMIN domain K02666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 494.0
HKD1_k127_3088777_4 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002298 480.0
HKD1_k127_3088777_5 Type IV pilus assembly protein PilM; K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 432.0
HKD1_k127_3088777_6 Bacterial regulatory protein, Fis family K07714 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 427.0
HKD1_k127_3088777_7 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005102 374.0
HKD1_k127_3088777_8 Phage integrase, N-terminal SAM-like domain K03733 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 316.0
HKD1_k127_3088777_9 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009262 278.0
HKD1_k127_3153578_0 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000000000001311 209.0
HKD1_k127_3153578_1 Outer membrane protein beta-barrel domain - - - 0.0003546 51.0
HKD1_k127_3160307_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 2.949e-275 872.0
HKD1_k127_3160307_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.116e-234 748.0
HKD1_k127_3160307_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000379 209.0
HKD1_k127_3160307_11 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000000007914 186.0
HKD1_k127_3160307_12 Two component regulator propeller - - - 0.0000000000000000000000000000000000000000000001146 190.0
HKD1_k127_3160307_13 - - - - 0.000000000000000000000000000000002333 141.0
HKD1_k127_3160307_14 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000001026 132.0
HKD1_k127_3160307_15 - - - - 0.0000000000000000000000000005488 113.0
HKD1_k127_3160307_16 PFAM BioY protein K03523 - - 0.0000000000000000000000002647 118.0
HKD1_k127_3160307_17 Hsp20/alpha crystallin family - - - 0.0000000000000000001864 94.0
HKD1_k127_3160307_18 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000002415 73.0
HKD1_k127_3160307_19 Bacterial Ig-like domain - - - 0.0000001871 65.0
HKD1_k127_3160307_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 5.75e-206 661.0
HKD1_k127_3160307_3 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000543 539.0
HKD1_k127_3160307_4 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008328 519.0
HKD1_k127_3160307_5 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00263 - 1.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003268 476.0
HKD1_k127_3160307_6 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 473.0
HKD1_k127_3160307_7 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 374.0
HKD1_k127_3160307_8 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009662 294.0
HKD1_k127_3160307_9 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000001021 228.0
HKD1_k127_3246231_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 3.434e-308 957.0
HKD1_k127_3246231_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 3.1e-298 932.0
HKD1_k127_3246231_2 RadC-like JAB domain K03630 - - 0.0000000000000000000000000000000000000000000000000002218 187.0
HKD1_k127_3246231_3 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000003818 185.0
HKD1_k127_3246231_4 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.00000000000000000000000000000000000001113 151.0
HKD1_k127_3246231_5 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925,K07102 - 2.7.1.221 0.0000000000000000000000000000002911 128.0
HKD1_k127_3246231_6 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.0000000000000000000000000001503 123.0
HKD1_k127_3246231_7 Universal bacterial protein YeaZ K14742 - - 0.00000000000000001881 94.0
HKD1_k127_3246231_8 LysM domain - - - 0.000000000262 72.0
HKD1_k127_32757_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006853 551.0
HKD1_k127_32757_1 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 507.0
HKD1_k127_32757_10 Cell cycle protein K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005767 278.0
HKD1_k127_32757_11 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003178 271.0
HKD1_k127_32757_12 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005911 264.0
HKD1_k127_32757_13 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000001139 156.0
HKD1_k127_32757_14 bacterial-type flagellum-dependent cell motility - - - 0.0000000000000000000000000000000000001251 160.0
HKD1_k127_32757_15 Two component signalling adaptor domain K03408 - - 0.000000000000000000000000000001773 128.0
HKD1_k127_32757_16 Cell division protein FtsQ K03589 - - 0.000000000000000000000007722 113.0
HKD1_k127_32757_17 Two component signalling adaptor domain K03408 - - 0.00000000001379 72.0
HKD1_k127_32757_19 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00003087 48.0
HKD1_k127_32757_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000906 467.0
HKD1_k127_32757_3 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004724 428.0
HKD1_k127_32757_4 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000705 449.0
HKD1_k127_32757_5 Penicillin binding protein transpeptidase domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 435.0
HKD1_k127_32757_6 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 402.0
HKD1_k127_32757_7 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 318.0
HKD1_k127_32757_8 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 311.0
HKD1_k127_32757_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002852 285.0
HKD1_k127_3318295_0 PFAM Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003864 461.0
HKD1_k127_3318295_1 PFAM Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003681 452.0
HKD1_k127_3318295_10 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000381 199.0
HKD1_k127_3318295_11 Domain of unknown function (DUF3473) - - - 0.0000000000000000000000000000000000000000000000000005122 194.0
HKD1_k127_3318295_12 xylanase chitin deacetylase - - - 0.00000000000000000000000000000000000000003806 168.0
HKD1_k127_3318295_13 O-Antigen ligase - - - 0.00000000000000000000000000000000002722 154.0
HKD1_k127_3318295_14 dTDP biosynthetic process K00560,K00943 - 2.1.1.45,2.7.4.9 0.00000162 59.0
HKD1_k127_3318295_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 374.0
HKD1_k127_3318295_3 ATP binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 351.0
HKD1_k127_3318295_4 ATP binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 337.0
HKD1_k127_3318295_5 Fibronectin type 3 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009831 315.0
HKD1_k127_3318295_6 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 304.0
HKD1_k127_3318295_7 Fibronectin type 3 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001996 296.0
HKD1_k127_3318295_8 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001957 278.0
HKD1_k127_3318295_9 ATP-grasp - - - 0.000000000000000000000000000000000000000000000000000008025 207.0
HKD1_k127_3318870_0 GXGXG motif K00265 - 1.4.1.13,1.4.1.14 0.0 1499.0
HKD1_k127_3318870_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1149.0
HKD1_k127_3318870_10 diguanylate cyclase K02488 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 454.0
HKD1_k127_3318870_11 Belongs to the thiolase family K07508 - 2.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003995 444.0
HKD1_k127_3318870_12 PFAM thiamine pyrophosphate enzyme K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005012 444.0
HKD1_k127_3318870_13 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004725 432.0
HKD1_k127_3318870_14 Saccharopine dehydrogenase C-terminal domain K19064 - 1.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 440.0
HKD1_k127_3318870_15 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 388.0
HKD1_k127_3318870_16 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 377.0
HKD1_k127_3318870_17 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007913 368.0
HKD1_k127_3318870_18 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 364.0
HKD1_k127_3318870_19 FAD linked oxidases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 372.0
HKD1_k127_3318870_2 Dehydrogenase K00117 - 1.1.5.2 8.898e-262 820.0
HKD1_k127_3318870_20 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 357.0
HKD1_k127_3318870_21 ATP-grasp domain K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 349.0
HKD1_k127_3318870_22 Peptidase family M1 domain K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000807 363.0
HKD1_k127_3318870_23 Dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 344.0
HKD1_k127_3318870_24 PFAM Band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 314.0
HKD1_k127_3318870_25 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008536 305.0
HKD1_k127_3318870_26 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000006147 254.0
HKD1_k127_3318870_27 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000276 235.0
HKD1_k127_3318870_28 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000004592 213.0
HKD1_k127_3318870_29 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000002856 206.0
HKD1_k127_3318870_3 Pyruvate flavodoxin ferredoxin K00174 - 1.2.7.11,1.2.7.3 3.142e-247 778.0
HKD1_k127_3318870_30 Nitrogen regulatory protein P-II K04751 - - 0.000000000000000000000000000000000000000000000000001418 186.0
HKD1_k127_3318870_31 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000000000000000000000000000000000009125 189.0
HKD1_k127_3318870_32 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.000000000000000000000000000000000000000000007215 179.0
HKD1_k127_3318870_33 PFAM blue (type 1) copper domain protein K00368,K02638 - 1.7.2.1 0.0000000000000000000000000000000000000000005078 174.0
HKD1_k127_3318870_34 Peptidase family S41 K03797 - 3.4.21.102 0.0000000000000000000000000000000000000005576 164.0
HKD1_k127_3318870_35 Amidohydrolase family - - - 0.00000000000000000000000000000000000004009 162.0
HKD1_k127_3318870_36 Thioredoxin - - - 0.0000000000000000000000000000000000008029 146.0
HKD1_k127_3318870_37 radical SAM domain protein - - - 0.00000000000000000000000000000000008795 144.0
HKD1_k127_3318870_38 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000286 130.0
HKD1_k127_3318870_39 - - - - 0.00000000000000000000000000001614 130.0
HKD1_k127_3318870_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 2.212e-238 758.0
HKD1_k127_3318870_40 - - - - 0.0000000000000000000000000001382 128.0
HKD1_k127_3318870_41 Protein of unknown function (DUF983) - - - 0.00000000000000000000000141 108.0
HKD1_k127_3318870_42 Calcium/calmodulin dependent protein kinase II association domain - - - 0.00000000000000000000001795 108.0
HKD1_k127_3318870_43 dCMP deaminase activity K01493 - 3.5.4.12 0.0000000000000000000003683 104.0
HKD1_k127_3318870_44 WD40-like Beta Propeller Repeat K03641 - - 0.000000000000000000007972 108.0
HKD1_k127_3318870_45 Mycolic acid cyclopropane synthetase - - - 0.00000000000006407 84.0
HKD1_k127_3318870_46 PFAM Bacterial regulatory proteins, tetR family - - - 0.0000000000347 71.0
HKD1_k127_3318870_48 - - - - 0.0000001628 60.0
HKD1_k127_3318870_49 metallophosphoesterase - - - 0.0000005852 60.0
HKD1_k127_3318870_5 Amidohydrolase family K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 552.0
HKD1_k127_3318870_50 - - - - 0.00001726 51.0
HKD1_k127_3318870_51 Universal stress protein family - - - 0.0004057 51.0
HKD1_k127_3318870_6 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 516.0
HKD1_k127_3318870_7 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 490.0
HKD1_k127_3318870_8 lysine 2,3-aminomutase activity K01843 - 5.4.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 450.0
HKD1_k127_3318870_9 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 447.0
HKD1_k127_3488189_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006008 505.0
HKD1_k127_3488189_1 Diguanylate cyclase, GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 317.0
HKD1_k127_3488189_10 Unextendable partial coding region - - - 0.00002032 49.0
HKD1_k127_3488189_11 - - - - 0.00006681 45.0
HKD1_k127_3488189_2 PFAM Sodium calcium exchanger protein K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005019 299.0
HKD1_k127_3488189_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004727 279.0
HKD1_k127_3488189_4 Sulfite exporter TauE/SafE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003135 280.0
HKD1_k127_3488189_5 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004725 275.0
HKD1_k127_3488189_6 High-affinity nickel-transport protein K07241 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003136 267.0
HKD1_k127_3488189_7 - - - - 0.0000000000000000000000000000000000000000000000006032 194.0
HKD1_k127_3488189_8 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism - - - 0.0000000000000000000000000000000000000000001044 172.0
HKD1_k127_3488189_9 Belongs to the UPF0434 family K09791 - - 0.0000000000002072 74.0
HKD1_k127_3551512_0 Response regulator receiver - - - 3.18e-196 620.0
HKD1_k127_3551512_1 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008501 605.0
HKD1_k127_3551512_10 23S rRNA-intervening sequence protein - - - 0.000000000000000000000000000000001118 135.0
HKD1_k127_3551512_11 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000001463 133.0
HKD1_k127_3551512_12 - - - - 0.000000000244 70.0
HKD1_k127_3551512_13 Protein of unknown function (DUF1569) - - - 0.000000001154 66.0
HKD1_k127_3551512_14 efflux transmembrane transporter activity - - - 0.000000001537 63.0
HKD1_k127_3551512_2 efflux transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 565.0
HKD1_k127_3551512_3 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 562.0
HKD1_k127_3551512_4 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009247 481.0
HKD1_k127_3551512_5 PFAM ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002937 370.0
HKD1_k127_3551512_6 lipoprotein transporter activity K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 346.0
HKD1_k127_3551512_7 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000000000000000000000000474 203.0
HKD1_k127_3551512_8 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000001457 208.0
HKD1_k127_3551512_9 - - - - 0.0000000000000000000000000000000000000000001025 175.0
HKD1_k127_3578871_0 Exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 554.0
HKD1_k127_3578871_1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 531.0
HKD1_k127_3578871_2 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms K01992,K07027,K14205 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008497 421.0
HKD1_k127_3578871_3 Proton-conducting membrane transporter K12141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 398.0
HKD1_k127_3578871_4 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 287.0
HKD1_k127_362885_0 AcrB/AcrD/AcrF family K03296 - - 3.086e-199 642.0
HKD1_k127_362885_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000003903 222.0
HKD1_k127_362885_2 bacterial OsmY and nodulation domain - - - 0.00000000000000000000000000000000000000000000000000000001631 208.0
HKD1_k127_362885_3 SMART PAS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000108 200.0
HKD1_k127_362885_4 - - - - 0.000000000000000000000000000000000000000559 163.0
HKD1_k127_3654099_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 450.0
HKD1_k127_3654099_1 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 408.0
HKD1_k127_3654099_2 Asparaginase K01444 - 3.5.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 357.0
HKD1_k127_3654099_3 Aminotransferase class-V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 304.0
HKD1_k127_3654099_4 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001199 284.0
HKD1_k127_3654099_5 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001871 260.0
HKD1_k127_3654099_6 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000000000001297 219.0
HKD1_k127_3654099_7 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281 - 3.5.1.19 0.00000000000000000000000000007346 127.0
HKD1_k127_3654099_8 Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length K01716 - 4.2.1.59,5.3.3.14 0.0000000001024 70.0
HKD1_k127_3670821_0 Carboxyl transferase domain - - - 5.415e-234 733.0
HKD1_k127_3670821_1 Subtilase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004462 316.0
HKD1_k127_3670821_2 B12 binding domain K01849 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000001119 220.0
HKD1_k127_3802595_0 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 599.0
HKD1_k127_3802595_1 secondary active sulfate transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 562.0
HKD1_k127_3802595_2 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003173 390.0
HKD1_k127_3802595_3 PFAM M42 glutamyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 381.0
HKD1_k127_3802595_4 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000002013 220.0
HKD1_k127_3802595_5 D,D-heptose 1,7-bisphosphate phosphatase K03273,K15669 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 2.7.7.71,3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000002597 172.0
HKD1_k127_3802595_6 COGs COG0265 Trypsin-like serine protease typically periplasmic contain C-terminal PDZ domain K04771 - 3.4.21.107 0.000000000000000000000000000000002017 149.0
HKD1_k127_3802595_7 serine-type endopeptidase activity K09973 - - 0.000001884 61.0
HKD1_k127_3802595_8 Peptidase family M1 domain K01256,K08776 - 3.4.11.2 0.00002464 52.0
HKD1_k127_384144_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 - 1.12.99.6 3.905e-242 762.0
HKD1_k127_384144_1 Belongs to the carbamoyltransferase HypF family K04656 - - 5.951e-212 692.0
HKD1_k127_384144_10 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001116 285.0
HKD1_k127_384144_11 Cytochrome b/b6/petB K00412,K03888 - - 0.00000000000000000000000000000000000000000000000000000000000002059 232.0
HKD1_k127_384144_12 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.00000000000000000000000000000000000000000000000000000000000002567 222.0
HKD1_k127_384144_13 Cytochrome c554 and c-prime K03620 - - 0.0000000000000000000000000000000000000000000000000000002773 216.0
HKD1_k127_384144_14 respiratory electron transport chain K03620 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494 - 0.0000000000000000000000000000000000000000000000000000133 205.0
HKD1_k127_384144_15 - - - - 0.000000000000000000000000000000000000000000000001159 186.0
HKD1_k127_384144_16 PFAM Enoyl-CoA hydratase isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000002049 177.0
HKD1_k127_384144_17 Hemerythrin HHE cation binding K07322 - - 0.0000000000000000000000000000000000000000002096 165.0
HKD1_k127_384144_18 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000009226 157.0
HKD1_k127_384144_19 Psort location Cytoplasmic, score - - - 0.0000000000000000000000000000000000003504 152.0
HKD1_k127_384144_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 614.0
HKD1_k127_384144_20 - - - - 0.00000000000000000000000000000000001593 149.0
HKD1_k127_384144_21 hydrogenase maturation protease K03605 - - 0.000000000000000000000000000000003873 134.0
HKD1_k127_384144_22 - - - - 0.00000000000000000000000000000005243 141.0
HKD1_k127_384144_23 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000001361 137.0
HKD1_k127_384144_24 carbon dioxide binding K04653,K04654 - - 0.00000000000000000000000000003309 125.0
HKD1_k127_384144_25 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 0.00000000000000000325 99.0
HKD1_k127_384144_26 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.000000000004929 76.0
HKD1_k127_384144_27 Protein of unknown function (DUF2892) - - - 0.00000003936 61.0
HKD1_k127_384144_28 Cytochrome c7 and related cytochrome c - - - 0.00000004745 66.0
HKD1_k127_384144_29 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000009941 63.0
HKD1_k127_384144_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006937 536.0
HKD1_k127_384144_30 subunit (C K02119 - - 0.0000002321 63.0
HKD1_k127_384144_31 PFAM Rieske 2Fe-2S domain protein K02636 - 1.10.9.1 0.0000003519 59.0
HKD1_k127_384144_32 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0006266 52.0
HKD1_k127_384144_33 Zn finger protein HypA HybF (Possibly regulating hydrogenase expression) K04651 - - 0.000842 46.0
HKD1_k127_384144_4 Hydrogenase formation hypA family K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004883 498.0
HKD1_k127_384144_5 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003919 465.0
HKD1_k127_384144_6 Small subunit K06282 - 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 428.0
HKD1_k127_384144_7 denitrification pathway K02569,K15876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 379.0
HKD1_k127_384144_8 PFAM V-type ATPase 116 kDa K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 311.0
HKD1_k127_384144_9 Prokaryotic cytochrome b561 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000746 292.0
HKD1_k127_3856600_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 2.059e-271 842.0
HKD1_k127_3856600_1 Glycosyl transferase 4-like K00754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004929 428.0
HKD1_k127_3856600_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 391.0
HKD1_k127_3856600_3 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000105 259.0
HKD1_k127_3856600_4 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000002886 231.0
HKD1_k127_3856600_5 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000000000001835 198.0
HKD1_k127_3856600_6 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.0000000000000000000000000000000000000006266 159.0
HKD1_k127_3856600_7 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000000002604 139.0
HKD1_k127_3856600_8 NlpC/P60 family - - - 0.0000000000000000000000001061 120.0
HKD1_k127_3856600_9 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000001482 96.0
HKD1_k127_3941578_0 TIGRFAM DNA polymerase III, alpha subunit K02337,K14162 - 2.7.7.7 3.89e-299 955.0
HKD1_k127_3941578_1 tRNA synthetases class I (M) K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 565.0
HKD1_k127_3941578_10 PSP1 C-terminal conserved region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000104 334.0
HKD1_k127_3941578_11 histidine kinase A domain protein K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006414 325.0
HKD1_k127_3941578_12 Putative aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004792 296.0
HKD1_k127_3941578_13 Oxidoreductase molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009828 255.0
HKD1_k127_3941578_14 domain, Protein K01179,K07260,K13735 - 3.2.1.4,3.4.17.14 0.000000000000000000000000000000000000000000000000000000000000000000007636 256.0
HKD1_k127_3941578_15 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000000002668 225.0
HKD1_k127_3941578_16 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000001266 203.0
HKD1_k127_3941578_17 Glycine oxidase K03153 - 1.4.3.19 0.0000000000000000000000000000000000000000000000000000002967 211.0
HKD1_k127_3941578_18 - - - - 0.000000000000000000000000000000000000000000000000000007914 198.0
HKD1_k127_3941578_19 Glycosyl transferase family 2 K08301 - - 0.000000000000000000000000000000000000000000000000003671 200.0
HKD1_k127_3941578_2 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 504.0
HKD1_k127_3941578_20 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000482 191.0
HKD1_k127_3941578_21 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000001297 180.0
HKD1_k127_3941578_22 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000000000005816 188.0
HKD1_k127_3941578_23 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000002585 185.0
HKD1_k127_3941578_24 Peptidase family M23 - - - 0.00000000000000000000000000000000000000001289 169.0
HKD1_k127_3941578_25 - - - - 0.00000000000000000000000000000000000002346 156.0
HKD1_k127_3941578_26 Peptidase C26 K07010 - - 0.0000000000000000000000000000003465 127.0
HKD1_k127_3941578_27 nucleotidyltransferase activity - - - 0.0000000000000000000000001201 117.0
HKD1_k127_3941578_28 Sodium/hydrogen exchanger family - - - 0.000000000000000001487 99.0
HKD1_k127_3941578_29 - - - - 0.0000000184 59.0
HKD1_k127_3941578_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 425.0
HKD1_k127_3941578_30 long-chain fatty acid transport protein - - - 0.0000004994 61.0
HKD1_k127_3941578_31 PFAM Protein kinase domain - - - 0.00008302 54.0
HKD1_k127_3941578_4 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 428.0
HKD1_k127_3941578_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005726 424.0
HKD1_k127_3941578_6 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 415.0
HKD1_k127_3941578_7 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000624 421.0
HKD1_k127_3941578_8 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 388.0
HKD1_k127_3941578_9 peptidyl-lysine modification to peptidyl-hypusine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 377.0
HKD1_k127_400340_0 Fumarase C C-terminus K01744 - 4.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 582.0
HKD1_k127_400340_1 Transketolase, pyrimidine binding domain K00167,K11381,K21417 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 505.0
HKD1_k127_400340_10 KR domain - - - 0.0000000000000000000000000006005 123.0
HKD1_k127_400340_11 - - - - 0.00000000000000000009855 91.0
HKD1_k127_400340_12 Redoxin - - - 0.000000000000001376 79.0
HKD1_k127_400340_13 Domain of unknown function (DUF309) K09763 - - 0.000000000000893 72.0
HKD1_k127_400340_14 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000003095 72.0
HKD1_k127_400340_15 Redoxin K03564 - 1.11.1.15 0.0000009366 51.0
HKD1_k127_400340_2 ThiF family K03148,K21029,K21147 - 2.7.7.73,2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007426 459.0
HKD1_k127_400340_3 e3 binding domain K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 414.0
HKD1_k127_400340_4 FAD dependent oxidoreductase K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009347 312.0
HKD1_k127_400340_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000001628 229.0
HKD1_k127_400340_6 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.00000000000000000000000000000000000000000000000000000000000001095 228.0
HKD1_k127_400340_7 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000007178 199.0
HKD1_k127_400340_8 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000000000001559 189.0
HKD1_k127_400340_9 - - - - 0.00000000000000000000000000000000000000000000000008503 187.0
HKD1_k127_4048441_0 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 7.022e-282 883.0
HKD1_k127_4048441_1 AMP-binding enzyme C-terminal domain K01907 - 6.2.1.16 1.328e-259 818.0
HKD1_k127_4048441_10 CAAX protease self-immunity K07052 - - 0.00000000000000000000000000000000000000000000000000000005076 204.0
HKD1_k127_4048441_11 Evidence 4 Homologs of previously reported genes of K15977 - - 0.000000000000000000000000000000000000000003076 159.0
HKD1_k127_4048441_12 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000004858 148.0
HKD1_k127_4048441_13 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000000000001807 134.0
HKD1_k127_4048441_14 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000003072 125.0
HKD1_k127_4048441_15 Pyridoxal-phosphate dependent enzyme - - - 0.0000000000000000000002725 100.0
HKD1_k127_4048441_17 Peptidase family M48 - - - 0.000000003166 59.0
HKD1_k127_4048441_18 Cupredoxin-like domain - - - 0.0001095 50.0
HKD1_k127_4048441_2 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000637 434.0
HKD1_k127_4048441_3 Nitronate monooxygenase K00459,K02371 - 1.13.12.16,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 406.0
HKD1_k127_4048441_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K07104 - 1.13.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003217 361.0
HKD1_k127_4048441_5 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00499,K16319 - 1.14.12.1,1.14.15.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004004 342.0
HKD1_k127_4048441_6 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 321.0
HKD1_k127_4048441_7 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008368 280.0
HKD1_k127_4048441_8 Belongs to the short-chain dehydrogenases reductases (SDR) family K05886 - 1.1.1.276 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001144 282.0
HKD1_k127_4048441_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005293 270.0
HKD1_k127_4048875_0 Large extracellular alpha-helical protein K06894 - - 0.0 1034.0
HKD1_k127_4048875_1 Large extracellular alpha-helical protein K06894 - - 3.807e-285 899.0
HKD1_k127_4048875_10 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 315.0
HKD1_k127_4048875_11 Activator of Hsp90 ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000004721 235.0
HKD1_k127_4048875_12 pfkB family carbohydrate kinase K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000749 246.0
HKD1_k127_4048875_13 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000001555 214.0
HKD1_k127_4048875_14 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000003735 199.0
HKD1_k127_4048875_15 InterPro IPR014922 - - - 0.00000000000000000000000000000000000000000000000000001705 192.0
HKD1_k127_4048875_16 DinB family - - - 0.00000000000000000000000000000000000000000000000000017 191.0
HKD1_k127_4048875_17 - - - - 0.0000000000000000000000000000000000000000000000000002542 205.0
HKD1_k127_4048875_18 Esterase PHB depolymerase K03932 - - 0.00000000000000000000000000000000000000000000000000524 196.0
HKD1_k127_4048875_19 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000000000000002389 184.0
HKD1_k127_4048875_2 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 3.134e-216 692.0
HKD1_k127_4048875_20 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000000006423 176.0
HKD1_k127_4048875_21 - - - - 0.00000000000000000000000000000000000000000007773 177.0
HKD1_k127_4048875_22 SnoaL-like domain - - - 0.000000000000000000000000000000000000001003 153.0
HKD1_k127_4048875_23 Haem-binding domain - - - 0.00000000000000000000000001434 114.0
HKD1_k127_4048875_24 Fibronectin type 3 domain K12685,K16785,K16786,K16787 - - 0.000000000000000002624 101.0
HKD1_k127_4048875_25 DinB family - - - 0.000000005768 64.0
HKD1_k127_4048875_26 Psort location Cytoplasmic, score - - - 0.00004506 51.0
HKD1_k127_4048875_3 ABC transporter transmembrane region K11085 - - 6.496e-216 687.0
HKD1_k127_4048875_4 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 615.0
HKD1_k127_4048875_5 Glycosyl hydrolases family 32 K03332 - 3.2.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007571 516.0
HKD1_k127_4048875_6 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 505.0
HKD1_k127_4048875_7 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 424.0
HKD1_k127_4048875_8 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 322.0
HKD1_k127_4048875_9 bacterial-type flagellum-dependent cell motility - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002771 351.0
HKD1_k127_4075374_0 2-oxoglutarate dehydrogenase N-terminus K00164 - 1.2.4.2 2.476e-304 972.0
HKD1_k127_4075374_1 Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 4.834e-259 811.0
HKD1_k127_4075374_10 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004202 567.0
HKD1_k127_4075374_11 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009421 484.0
HKD1_k127_4075374_12 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004679 462.0
HKD1_k127_4075374_13 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003705 464.0
HKD1_k127_4075374_14 PFAM Protein kinase K03413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 457.0
HKD1_k127_4075374_15 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 415.0
HKD1_k127_4075374_16 Pyridine nucleotide-disulphide oxidoreductase K21567 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005458 404.0
HKD1_k127_4075374_17 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 390.0
HKD1_k127_4075374_18 Surface antigen K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 392.0
HKD1_k127_4075374_19 4Fe-4S binding domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007921 376.0
HKD1_k127_4075374_2 lysine biosynthetic process via aminoadipic acid - - - 1.365e-232 749.0
HKD1_k127_4075374_20 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 400.0
HKD1_k127_4075374_21 Domain of Unknown Function (DUF1080) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 356.0
HKD1_k127_4075374_22 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007322 341.0
HKD1_k127_4075374_23 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 332.0
HKD1_k127_4075374_24 mannose metabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 360.0
HKD1_k127_4075374_25 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 344.0
HKD1_k127_4075374_26 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004948 334.0
HKD1_k127_4075374_27 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005461 332.0
HKD1_k127_4075374_28 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006152 311.0
HKD1_k127_4075374_29 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009251 297.0
HKD1_k127_4075374_3 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 3.386e-218 686.0
HKD1_k127_4075374_30 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003293 287.0
HKD1_k127_4075374_31 PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003345 287.0
HKD1_k127_4075374_32 Domain of unknown function (DUF3471) K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001868 291.0
HKD1_k127_4075374_33 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000005656 269.0
HKD1_k127_4075374_34 Cytochrome c K07243 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008552 281.0
HKD1_k127_4075374_35 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000003321 262.0
HKD1_k127_4075374_36 Peptidase family S58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005773 257.0
HKD1_k127_4075374_37 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001062 261.0
HKD1_k127_4075374_38 Zn_pept - - - 0.000000000000000000000000000000000000000000000000000000000000000000002354 264.0
HKD1_k127_4075374_39 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000001101 244.0
HKD1_k127_4075374_4 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 1.722e-208 660.0
HKD1_k127_4075374_40 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000008856 239.0
HKD1_k127_4075374_41 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000005676 218.0
HKD1_k127_4075374_42 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000001226 216.0
HKD1_k127_4075374_43 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000004591 220.0
HKD1_k127_4075374_44 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000000001651 198.0
HKD1_k127_4075374_45 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000000008375 196.0
HKD1_k127_4075374_46 Domain of Unknown Function (DUF1259) - - - 0.0000000000000000000000000000000000000000000003486 179.0
HKD1_k127_4075374_47 NlpC/P60 family - - - 0.00000000000000000000000000000000000000002733 166.0
HKD1_k127_4075374_48 FAD linked oxidases, C-terminal domain K11472 - - 0.0000000000000000000000000000000000000006499 163.0
HKD1_k127_4075374_49 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000121 156.0
HKD1_k127_4075374_5 von Willebrand factor (vWF) type A domain - - - 6.12e-203 640.0
HKD1_k127_4075374_50 Diacylglycerol kinase catalytic domain (presumed) K07029 - 2.7.1.107 0.0000000000000000000000000000000000001131 158.0
HKD1_k127_4075374_51 Glutathione peroxidase - - - 0.0000000000000000000000000000000003531 138.0
HKD1_k127_4075374_52 PFAM NAD dependent epimerase dehydratase family - - - 0.000000000000000000000000000000000502 145.0
HKD1_k127_4075374_53 DinB family - - - 0.0000000000000000000000000000006127 127.0
HKD1_k127_4075374_54 YGGT family K02221 - - 0.000000000000000000000000000001382 134.0
HKD1_k127_4075374_55 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.000000000000000000000000000001515 129.0
HKD1_k127_4075374_56 HD domain - - - 0.00000000000000000000000000008623 127.0
HKD1_k127_4075374_57 CYTH domain K01768,K05873 - 4.6.1.1 0.00000000000000000000000000009969 124.0
HKD1_k127_4075374_58 Glycine cleavage T-protein C-terminal barrel domain K06980 - - 0.0000000000000000000000001003 123.0
HKD1_k127_4075374_6 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 558.0
HKD1_k127_4075374_60 Lanthionine synthetase C family protein - - - 0.0000000000000000000007182 104.0
HKD1_k127_4075374_61 Belongs to the UPF0235 family K09131 - - 0.000000000000000001925 88.0
HKD1_k127_4075374_62 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000002722 97.0
HKD1_k127_4075374_63 Preprotein translocase subunit K03210 - - 0.00000000000000001482 94.0
HKD1_k127_4075374_64 Psort location Cytoplasmic, score K00945,K01812,K16139 - 2.7.4.25,5.3.1.12 0.00000000000000001963 93.0
HKD1_k127_4075374_65 - - - - 0.000000000000001496 78.0
HKD1_k127_4075374_66 - - - - 0.0000000000001145 81.0
HKD1_k127_4075374_67 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000000002156 77.0
HKD1_k127_4075374_68 ThiS family K03154 - - 0.0000000005916 70.0
HKD1_k127_4075374_69 Histidine kinase - - - 0.00000008048 57.0
HKD1_k127_4075374_7 enterobactin catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003799 546.0
HKD1_k127_4075374_70 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.00000008603 63.0
HKD1_k127_4075374_71 Membrane - - - 0.0000003164 61.0
HKD1_k127_4075374_72 YbbR-like protein - - - 0.00003212 55.0
HKD1_k127_4075374_8 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 564.0
HKD1_k127_4075374_9 PFAM cytochrome bd ubiquinol oxidase subunit I K00425 - 1.10.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 525.0
HKD1_k127_4076852_0 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 631.0
HKD1_k127_4076852_1 ABC-type multidrug transport system ATPase and permease K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002799 609.0
HKD1_k127_4076852_10 polysaccharide catabolic process K03478 - 3.5.1.105 0.000000000000000000000000000000000000008692 161.0
HKD1_k127_4076852_11 Glycosyltransferase Family 4 - - - 0.000000000000000000000001351 116.0
HKD1_k127_4076852_12 Phosphotransferase enzyme family - - - 0.0000003012 62.0
HKD1_k127_4076852_13 Phosphotransferase enzyme family - - - 0.000004446 59.0
HKD1_k127_4076852_2 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 411.0
HKD1_k127_4076852_3 ABC transporter transmembrane region K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006707 308.0
HKD1_k127_4076852_4 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000009448 229.0
HKD1_k127_4076852_5 Glycosyl transferase family 2 K12984 - - 0.00000000000000000000000000000000000000000000000000000000397 207.0
HKD1_k127_4076852_6 transferase activity, transferring glycosyl groups K00713,K06338 - - 0.0000000000000000000000000000000000000000000000000000004454 205.0
HKD1_k127_4076852_7 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000001766 209.0
HKD1_k127_4076852_8 Glycosyl transferases group 1 K13668 - 2.4.1.346 0.0000000000000000000000000000000000000000000000000003442 203.0
HKD1_k127_4076852_9 PFAM Glycosyl transferase, group 1 K13668 GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.346 0.000000000000000000000000000000000000005814 163.0
HKD1_k127_4096788_0 PA14 domain K05349 - 3.2.1.21 2.5e-322 1009.0
HKD1_k127_4096788_1 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 5.374e-205 659.0
HKD1_k127_4096788_10 Transglycosylase associated protein - - - 0.00000000000000000000003599 101.0
HKD1_k127_4096788_11 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000008494 59.0
HKD1_k127_4096788_12 Predicted membrane protein (DUF2214) - - - 0.0000792 51.0
HKD1_k127_4096788_13 cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.0003947 51.0
HKD1_k127_4096788_2 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 580.0
HKD1_k127_4096788_3 Pirin C-terminal cupin domain K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 473.0
HKD1_k127_4096788_4 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004452 492.0
HKD1_k127_4096788_5 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000005355 234.0
HKD1_k127_4096788_6 enterobactin catabolic process K07214 - - 0.0000000000000000000000000000000000000000000000000000000000004838 236.0
HKD1_k127_4096788_7 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000004179 211.0
HKD1_k127_4096788_8 BlaR1 peptidase M56 - - - 0.00000000000000000000000000000000000000000000001754 188.0
HKD1_k127_4096788_9 Penicillinase repressor - - - 0.0000000000000000000000000000000000000006406 151.0
HKD1_k127_4114827_0 Xaa-Pro aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008712 533.0
HKD1_k127_4114827_1 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007087 527.0
HKD1_k127_4114827_10 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000314 362.0
HKD1_k127_4114827_11 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009065 332.0
HKD1_k127_4114827_12 GlcNAc-PI de-N-acetylase K01463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 306.0
HKD1_k127_4114827_13 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002238 281.0
HKD1_k127_4114827_14 PFAM alanine racemase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000006334 244.0
HKD1_k127_4114827_15 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000003301 232.0
HKD1_k127_4114827_16 DoxX K16937 - 1.8.5.2 0.0000000000000000000000000000000000000000000000000000117 194.0
HKD1_k127_4114827_17 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000000000007785 178.0
HKD1_k127_4114827_18 Belongs to the acetyltransferase family. ArgA subfamily K00619 - 2.3.1.1 0.00000000000000000000000000000000000001622 148.0
HKD1_k127_4114827_19 PFAM Membrane protein of K08972 - - 0.00000000000000000000005199 109.0
HKD1_k127_4114827_2 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000764 519.0
HKD1_k127_4114827_20 - - - - 0.00000000001179 71.0
HKD1_k127_4114827_21 Glycosyltransferase family 87 K13671 - - 0.000000000195 74.0
HKD1_k127_4114827_22 - - - - 0.000000003677 65.0
HKD1_k127_4114827_24 Transposase K07491 - - 0.0003313 51.0
HKD1_k127_4114827_3 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 467.0
HKD1_k127_4114827_4 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005827 463.0
HKD1_k127_4114827_5 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005925 413.0
HKD1_k127_4114827_6 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 409.0
HKD1_k127_4114827_7 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 388.0
HKD1_k127_4114827_8 Aminotransferase class-V K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007419 359.0
HKD1_k127_4114827_9 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 366.0
HKD1_k127_4136435_0 cellulose binding - - - 2.847e-220 688.0
HKD1_k127_4136435_1 asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 578.0
HKD1_k127_4136435_2 Elongator protein 3, MiaB family, Radical SAM K06936 - - 0.0000000000000000000000000000000000000000000000000000000001167 229.0
HKD1_k127_4136435_3 Mo-molybdopterin cofactor metabolic process K03636,K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000003688 151.0
HKD1_k127_4136435_4 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000463 139.0
HKD1_k127_4151466_0 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 507.0
HKD1_k127_4151466_1 Aminotransferase class-III K03918,K07250,K20428 - 2.6.1.19,2.6.1.22,2.6.1.33,2.6.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004897 490.0
HKD1_k127_4151466_2 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005383 399.0
HKD1_k127_4151466_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000371 254.0
HKD1_k127_4151466_4 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K03802,K05844 - 6.3.2.29,6.3.2.30 0.0000000000000000000000000000000000000000006629 168.0
HKD1_k127_4151466_5 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000009072 139.0
HKD1_k127_4151466_6 Transcriptional regulator PadR-like family - - - 0.000000000000000000001266 100.0
HKD1_k127_4151466_7 Psort location Cytoplasmic, score 8.96 - - - 0.000000000000000003564 98.0
HKD1_k127_4151466_8 Acetyltransferase (GNAT) domain - - - 0.00001934 48.0
HKD1_k127_4151466_9 CDP-alcohol phosphatidyltransferase - - - 0.0001461 47.0
HKD1_k127_419888_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 2.654e-222 694.0
HKD1_k127_419888_1 Sortilin, neurotensin receptor 3, - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 494.0
HKD1_k127_419888_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 354.0
HKD1_k127_419888_3 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003534 275.0
HKD1_k127_419888_4 histidine kinase A domain protein K02482 - 2.7.13.3 0.000000000000000000000000000000000000000000009373 179.0
HKD1_k127_419888_5 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000001141 149.0
HKD1_k127_419888_6 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000002666 136.0
HKD1_k127_419888_7 - - - - 0.0000000000000000000000000001962 124.0
HKD1_k127_419888_8 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00002728 55.0
HKD1_k127_4383572_0 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 9.344e-292 911.0
HKD1_k127_4383572_1 Acyl-CoA dehydrogenase, C-terminal domain K18244 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 565.0
HKD1_k127_4383572_2 Ribonuclease E/G family K08301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009352 392.0
HKD1_k127_4383572_3 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 396.0
HKD1_k127_4383572_4 RecQ zinc-binding K03654 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 329.0
HKD1_k127_4383572_5 Disulphide isomerase - - - 0.00000000000000000000000000000000000000000000000003494 182.0
HKD1_k127_4383572_6 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - 0.000000000000000000000000000000000000003922 151.0
HKD1_k127_4383572_7 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0001328 53.0
HKD1_k127_4383832_0 transmembrane transporter activity K03296 - - 0.0 1289.0
HKD1_k127_4383832_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 1.803e-308 962.0
HKD1_k127_4383832_10 Domain of unknown function (DUF4386) - - - 0.00000000000000000000000000000000000000000000000000000003822 210.0
HKD1_k127_4383832_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000008836 186.0
HKD1_k127_4383832_12 protein homotetramerization - GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016043,GO:0022607,GO:0022803,GO:0022838,GO:0022840,GO:0022841,GO:0022842,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0043933,GO:0044085,GO:0046873,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0098655,GO:0098660,GO:0098662 - 0.000000000000000000000000000000000000009512 152.0
HKD1_k127_4383832_13 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000001038 110.0
HKD1_k127_4383832_14 - - - - 0.0000000000000001461 92.0
HKD1_k127_4383832_2 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005211 524.0
HKD1_k127_4383832_3 protein histidine kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 401.0
HKD1_k127_4383832_4 efflux transmembrane transporter activity K15725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009557 289.0
HKD1_k127_4383832_5 Pectinacetylesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001451 266.0
HKD1_k127_4383832_6 radical SAM domain protein K22226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000654 246.0
HKD1_k127_4383832_7 PFAM response regulator receiver K07665 - - 0.00000000000000000000000000000000000000000000000000000000000000001356 230.0
HKD1_k127_4383832_8 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000009075 220.0
HKD1_k127_4383832_9 - - - - 0.00000000000000000000000000000000000000000000000000000000002184 208.0
HKD1_k127_4386920_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 458.0
HKD1_k127_4386920_1 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 400.0
HKD1_k127_4386920_10 - - - - 0.000000000000000000000000000002044 124.0
HKD1_k127_4386920_11 Glycogen recognition site of AMP-activated protein kinase - - - 0.00000000000000000000000000001079 124.0
HKD1_k127_4386920_12 Peptidase, M23 - - - 0.00000000000000000000000004758 121.0
HKD1_k127_4386920_13 - - - - 0.00000000000000000000002077 107.0
HKD1_k127_4386920_14 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.000000000000003721 86.0
HKD1_k127_4386920_15 Polymer-forming cytoskeletal - - - 0.0000000000005988 76.0
HKD1_k127_4386920_16 Domain of unknown function (DUF4382) - - - 0.00000000002599 76.0
HKD1_k127_4386920_2 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 344.0
HKD1_k127_4386920_3 Cellulose biosynthesis protein BcsQ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006572 341.0
HKD1_k127_4386920_4 ParB-like nuclease domain K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008381 279.0
HKD1_k127_4386920_5 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000081 278.0
HKD1_k127_4386920_6 Belongs to the GTP cyclohydrolase I type 2 NIF3 family K22391 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000002265 223.0
HKD1_k127_4386920_7 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000000000002114 204.0
HKD1_k127_4386920_8 Metallophosphoesterase K07098 - - 0.0000000000000000000000000000000000000001741 170.0
HKD1_k127_4386920_9 - - - - 0.0000000000000000000000000000000008415 144.0
HKD1_k127_43947_0 ASPIC UnbV domain protein - - - 0.0 1247.0
HKD1_k127_43947_1 CarboxypepD_reg-like domain - - - 4.757e-284 920.0
HKD1_k127_43947_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 412.0
HKD1_k127_43947_11 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003533 366.0
HKD1_k127_43947_12 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 373.0
HKD1_k127_43947_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 327.0
HKD1_k127_43947_14 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002279 272.0
HKD1_k127_43947_15 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001139 296.0
HKD1_k127_43947_16 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009458 254.0
HKD1_k127_43947_17 ABC transporter, ATP-binding protein K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000003244 245.0
HKD1_k127_43947_18 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000368 237.0
HKD1_k127_43947_19 PFAM ASPIC UnbV domain protein - - - 0.00000000000000000000000000000000000000000000000000000000001345 234.0
HKD1_k127_43947_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.576e-253 790.0
HKD1_k127_43947_20 Cytochrome C oxidase, cbb3-type, subunit III K08738 - - 0.000000000000000000000000000000000000000000000000000001254 197.0
HKD1_k127_43947_21 NUDIX domain - - - 0.000000000000000000000000000000000000000000000002286 179.0
HKD1_k127_43947_22 - - - - 0.0000000000000000000000000000000000000000005297 158.0
HKD1_k127_43947_23 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000102 158.0
HKD1_k127_43947_24 TPM domain K06872 - - 0.0000000000000000000000000000000003419 141.0
HKD1_k127_43947_25 transport - - - 0.000000000000000000000000000000002389 138.0
HKD1_k127_43947_26 hydroperoxide reductase activity K01607 - 4.1.1.44 0.000000000000000000000000000000009291 128.0
HKD1_k127_43947_27 PFAM DSBA oxidoreductase - - - 0.000000000000000000000000000001931 128.0
HKD1_k127_43947_28 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.00000000000000001482 93.0
HKD1_k127_43947_29 - - - - 0.000000008468 60.0
HKD1_k127_43947_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.134e-251 782.0
HKD1_k127_43947_30 PFAM TonB-dependent Receptor Plug - - - 0.00000007287 60.0
HKD1_k127_43947_31 - - - - 0.0000004996 60.0
HKD1_k127_43947_33 - - - - 0.00001197 57.0
HKD1_k127_43947_35 alginic acid biosynthetic process K10297 - - 0.00002578 47.0
HKD1_k127_43947_37 TonB-dependent receptor - - - 0.0004013 49.0
HKD1_k127_43947_38 Bacterial Ig-like domain 2 - - - 0.0009548 51.0
HKD1_k127_43947_4 TonB-dependent receptor - - - 3.783e-230 746.0
HKD1_k127_43947_5 PFAM glycoside hydrolase family 3 K05349 - 3.2.1.21 6.194e-228 732.0
HKD1_k127_43947_6 TonB-dependent receptor - - - 2.407e-219 715.0
HKD1_k127_43947_7 Mo-co oxidoreductase dimerisation domain K17225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 516.0
HKD1_k127_43947_8 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 462.0
HKD1_k127_43947_9 Protocatechuate 3,4-dioxygenase beta subunit K03381 - 1.13.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003371 403.0
HKD1_k127_4403783_0 Zinc carboxypeptidase - - - 1.09e-200 641.0
HKD1_k127_4403783_1 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005407 556.0
HKD1_k127_4403783_10 choline dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000009313 177.0
HKD1_k127_4403783_11 - - - - 0.00000000000000000000000000002159 120.0
HKD1_k127_4403783_12 tetratricopeptide repeat - - - 0.000000000004966 77.0
HKD1_k127_4403783_13 Extracellular solute-binding protein, family 5 K02035 - - 0.00000000008281 75.0
HKD1_k127_4403783_2 C4-dicarboxylate anaerobic carrier - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 543.0
HKD1_k127_4403783_3 Aldehyde dehydrogenase family K00128,K00135 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 529.0
HKD1_k127_4403783_4 Chromate transporter K07240 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 472.0
HKD1_k127_4403783_5 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 474.0
HKD1_k127_4403783_6 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005337 451.0
HKD1_k127_4403783_7 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 347.0
HKD1_k127_4403783_8 Proline dehydrogenase K00318 - - 0.00000000000000000000000000000000000000000000000000000000001334 219.0
HKD1_k127_4403783_9 signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000001961 206.0
HKD1_k127_4503657_0 Dehydrogenase K00117 - 1.1.5.2 2.661e-204 659.0
HKD1_k127_4503657_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 505.0
HKD1_k127_4503657_10 methylated-DNA-[protein]-cysteine S-methyltransferase activity K00567,K10778 GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.63 0.00000000000000000000000000000000000000000000000001752 186.0
HKD1_k127_4503657_11 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000001418 190.0
HKD1_k127_4503657_12 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.0000000000000000000000000000000000000000000004057 177.0
HKD1_k127_4503657_13 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000003579 147.0
HKD1_k127_4503657_14 40-residue YVTN family beta-propeller repeat - - - 0.000000000000000000000000001897 128.0
HKD1_k127_4503657_15 Protein of unknown function (DUF2892) - - - 0.00000000002151 64.0
HKD1_k127_4503657_16 Protein of unknown function (DUF3568) - - - 0.0000000005706 65.0
HKD1_k127_4503657_17 - - - - 0.00000007995 64.0
HKD1_k127_4503657_18 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.00007828 46.0
HKD1_k127_4503657_2 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003073 484.0
HKD1_k127_4503657_3 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006689 410.0
HKD1_k127_4503657_4 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 392.0
HKD1_k127_4503657_5 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000367 331.0
HKD1_k127_4503657_6 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304,K12267 - 1.8.4.11,1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 286.0
HKD1_k127_4503657_7 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002316 254.0
HKD1_k127_4503657_8 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000000000000000000000000000000000001026 244.0
HKD1_k127_4503657_9 belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000001174 234.0
HKD1_k127_4541661_0 Penicillin amidase - - - 1.035e-317 987.0
HKD1_k127_4541661_1 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 538.0
HKD1_k127_4541661_2 TrkA-C domain K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006791 494.0
HKD1_k127_4541661_3 response to abiotic stimulus K03086,K06867 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004042 457.0
HKD1_k127_4541661_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004554 299.0
HKD1_k127_4541661_5 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000000004326 241.0
HKD1_k127_4541661_6 - - - - 0.00000000000001223 76.0
HKD1_k127_4603404_0 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009135 539.0
HKD1_k127_4603404_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006006 348.0
HKD1_k127_4603404_2 - - - - 0.00000000009615 68.0
HKD1_k127_4603404_4 23S rRNA-intervening sequence protein - - - 0.000006732 54.0
HKD1_k127_4603404_5 photosystem II stabilization - - - 0.00003989 57.0
HKD1_k127_4650395_0 transmembrane transporter activity K18138 - - 0.0 1604.0
HKD1_k127_4650395_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 400.0
HKD1_k127_4650395_2 efflux transmembrane transporter activity K18300,K18308 - - 0.00000000000000000000000003917 116.0
HKD1_k127_4650395_3 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000005678 98.0
HKD1_k127_4662167_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 3.06e-206 652.0
HKD1_k127_4662167_1 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 565.0
HKD1_k127_4662167_2 Cell cycle protein K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 462.0
HKD1_k127_4662167_3 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008789 412.0
HKD1_k127_4662167_4 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 398.0
HKD1_k127_4662167_5 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 380.0
HKD1_k127_4662167_6 Mur ligase middle domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 315.0
HKD1_k127_4662167_7 Cupin domain - - - 0.00000000000000000000000000000000000000000000001079 179.0
HKD1_k127_4662167_8 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000000000000000000000000000000000000001834 171.0
HKD1_k127_4662167_9 rod shape-determining protein MreD K03571 - - 0.0000000000000002601 81.0
HKD1_k127_4699132_0 GMC oxidoreductase - - - 5.889e-292 905.0
HKD1_k127_4699132_1 Glycosyl hydrolases family 2, TIM barrel domain - - - 3.974e-290 940.0
HKD1_k127_4699132_10 PFAM Phenazine biosynthesis PhzC PhzF protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 346.0
HKD1_k127_4699132_11 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006657 341.0
HKD1_k127_4699132_12 PFAM cyclase family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 297.0
HKD1_k127_4699132_13 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003058 299.0
HKD1_k127_4699132_14 N-acetylglucosaminylinositol deacetylase activity K01463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007371 288.0
HKD1_k127_4699132_15 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 297.0
HKD1_k127_4699132_16 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002237 282.0
HKD1_k127_4699132_17 guanyl-nucleotide exchange factor activity K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006029 294.0
HKD1_k127_4699132_18 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004179 269.0
HKD1_k127_4699132_19 PFAM Acetyltransferase (GNAT) family K06976 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002435 264.0
HKD1_k127_4699132_2 penicillin binding K05367 - 2.4.1.129 2.626e-261 837.0
HKD1_k127_4699132_20 Gluconate 2-dehydrogenase subunit 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000493 242.0
HKD1_k127_4699132_21 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000001037 246.0
HKD1_k127_4699132_22 ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component - - - 0.0000000000000000000000000000000000000000000000000000000001652 209.0
HKD1_k127_4699132_23 TIGRFAM Carbohydrate kinase, thermoresistant glucokinase K00851 - 2.7.1.12 0.000000000000000000000000000000000000000000000000000319 191.0
HKD1_k127_4699132_24 Putative cyclase K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000006523 177.0
HKD1_k127_4699132_25 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000000000000000000001125 167.0
HKD1_k127_4699132_26 Protein of unknown function (DUF418) K07148 - - 0.000000000000000000000000000000000000000001247 171.0
HKD1_k127_4699132_27 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000001806 147.0
HKD1_k127_4699132_28 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000001817 149.0
HKD1_k127_4699132_29 Protein of unknown function (DUF3052) - - - 0.00000000000000000000000000000000000004888 160.0
HKD1_k127_4699132_3 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 546.0
HKD1_k127_4699132_30 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000005005 146.0
HKD1_k127_4699132_32 Endonuclease related to archaeal Holliday junction resolvase - - - 0.000000000000000000000000000008475 126.0
HKD1_k127_4699132_33 - - - - 0.0000000000000000000000001699 122.0
HKD1_k127_4699132_35 EamA-like transporter family - - - 0.0000000009595 71.0
HKD1_k127_4699132_36 - - - - 0.000001938 59.0
HKD1_k127_4699132_37 Carboxypeptidase regulatory-like domain - - - 0.0001663 53.0
HKD1_k127_4699132_4 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 558.0
HKD1_k127_4699132_5 Gluconate K03299 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008226 516.0
HKD1_k127_4699132_6 Converts alpha-aldose to the beta-anomer K01785 - 5.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 467.0
HKD1_k127_4699132_7 myo-inosose-2 dehydratase activity K01805,K03079 - 5.1.3.22,5.3.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 415.0
HKD1_k127_4699132_8 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 391.0
HKD1_k127_4699132_9 Peptidase family M1 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007016 351.0
HKD1_k127_4790325_0 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005399 359.0
HKD1_k127_4790325_1 L-asparaginase II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004776 329.0
HKD1_k127_4790325_2 Glycosyl transferase 4-like domain - - - 0.000000000000000000000000000000000000001469 162.0
HKD1_k127_4790325_3 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000003084 152.0
HKD1_k127_4790325_4 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000004257 132.0
HKD1_k127_4790325_5 23S rRNA-intervening sequence protein - - - 0.0000000000003992 72.0
HKD1_k127_4790325_6 Polysaccharide biosynthesis/export protein - - - 0.000000005411 63.0
HKD1_k127_4820411_0 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000891 563.0
HKD1_k127_4820411_1 xanthine dehydrogenase activity K04108 - 1.3.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 546.0
HKD1_k127_4820411_10 Tetratricopeptide repeat - - - 0.0000001877 65.0
HKD1_k127_4820411_11 - - - - 0.0001542 50.0
HKD1_k127_4820411_2 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 539.0
HKD1_k127_4820411_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 432.0
HKD1_k127_4820411_4 PFAM peptidase M19 renal dipeptidase K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 385.0
HKD1_k127_4820411_5 Peptidase family M1 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001316 306.0
HKD1_k127_4820411_6 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000001252 177.0
HKD1_k127_4820411_7 - - - - 0.00000000000000000000000000002185 123.0
HKD1_k127_4820411_8 PFAM YCII-related - - - 0.00000000000001258 79.0
HKD1_k127_4820411_9 - - - - 0.00000005589 60.0
HKD1_k127_4927082_0 ATP dependent DNA ligase domain protein K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 562.0
HKD1_k127_4927082_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002151 276.0
HKD1_k127_4927082_2 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000006542 230.0
HKD1_k127_4927082_3 YCII-related domain - - - 0.000000000000000000000000000000007266 132.0
HKD1_k127_4927082_4 PFAM blue (type 1) copper domain protein - - - 0.00000000001362 70.0
HKD1_k127_4995723_0 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003375 387.0
HKD1_k127_4995723_1 - - - - 0.000000000003363 71.0
HKD1_k127_4995723_2 - - - - 0.00000000001154 75.0
HKD1_k127_5087406_0 Beta-eliminating lyase K00639,K00652 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 503.0
HKD1_k127_5087406_1 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 358.0
HKD1_k127_5087406_2 Amino acid permease K20265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004816 289.0
HKD1_k127_5087406_3 M6 family metalloprotease domain protein - - - 0.0000000000000000000000000000000000006467 161.0
HKD1_k127_5087406_4 Leishmanolysin - - - 0.000000000000000000000000000007631 133.0
HKD1_k127_5087406_6 PKD domain containing protein K01337,K20276,K21449 - 3.4.21.50 0.00000009521 66.0
HKD1_k127_5219492_0 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007254 376.0
HKD1_k127_5219492_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001232 253.0
HKD1_k127_5219492_2 Roadblock/LC7 domain - - - 0.000000000000000000000000000000000000000000000000000000000005917 212.0
HKD1_k127_5219492_3 Competence-damaged protein K03742 - 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000435 220.0
HKD1_k127_5219492_4 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000000000000000006062 159.0
HKD1_k127_5219492_5 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0045926,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000002128 134.0
HKD1_k127_5219492_6 - - - - 0.0000000000000000000004948 98.0
HKD1_k127_5219492_7 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000000000000006076 80.0
HKD1_k127_5230680_0 Major facilitator Superfamily K00943,K08217,K18833 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 423.0
HKD1_k127_5230680_1 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010,K02052 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006235 300.0
HKD1_k127_5230680_2 Binding-protein-dependent transport system inner membrane component K02018 - - 0.0000000000000000000000000000000000000008231 152.0
HKD1_k127_5230680_3 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000374 143.0
HKD1_k127_5230680_4 Protein of unknown function (DUF1097) - - - 0.000000000000000000001157 107.0
HKD1_k127_5230680_5 Phospholipid methyltransferase - - - 0.000000000002325 78.0
HKD1_k127_5230680_6 PFAM Squalene phytoene synthase K00801 - 2.5.1.21 0.0000000004215 72.0
HKD1_k127_542473_0 Methylmalonyl-CoA mutase K01848,K11942 - 5.4.99.13,5.4.99.2 1.086e-257 807.0
HKD1_k127_542473_1 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 8.193e-214 687.0
HKD1_k127_542473_10 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000002894 219.0
HKD1_k127_542473_11 HD superfamily hydrolase involved in NAD metabolism K00950 - 2.7.6.3 0.00000000000000000000000000000000000006654 148.0
HKD1_k127_542473_12 HD superfamily hydrolase involved in NAD metabolism K00950 - 2.7.6.3 0.0000000000000000000000000000000000002437 154.0
HKD1_k127_542473_13 translation release factor activity K03265 GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.0000000000000000000000000000000002062 147.0
HKD1_k127_542473_14 HEAT repeats - - - 0.0000000000000000000000000000000005403 136.0
HKD1_k127_542473_15 CBS domain containing protein - - - 0.000000000000000000000000000004132 136.0
HKD1_k127_542473_16 histidine kinase HAMP region domain protein K03406 - - 0.0000000000000000000000000244 127.0
HKD1_k127_542473_17 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.000000000000000000000001497 115.0
HKD1_k127_542473_18 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000002646 107.0
HKD1_k127_542473_2 7TM receptor with intracellular HD hydrolase K07037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 518.0
HKD1_k127_542473_3 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004784 480.0
HKD1_k127_542473_4 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 426.0
HKD1_k127_542473_5 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006678 394.0
HKD1_k127_542473_6 ArgK protein K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005852 368.0
HKD1_k127_542473_7 3-methyl-2-oxobutanoate hydroxymethyltransferase activity K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 313.0
HKD1_k127_542473_8 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003823 276.0
HKD1_k127_542473_9 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000003327 268.0
HKD1_k127_5746436_0 lysine biosynthetic process via aminoadipic acid - - - 1.288e-242 772.0
HKD1_k127_5746436_1 radical SAM domain protein - - - 1.734e-225 710.0
HKD1_k127_5746436_2 Voltage gated chloride channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 584.0
HKD1_k127_5746436_3 Domain of unknown function(DUF2779) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 356.0
HKD1_k127_5746436_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000003981 223.0
HKD1_k127_5746436_5 alcohol dehydrogenase K13979 - - 0.000000000000000000000000000000000000000000000000000000006793 199.0
HKD1_k127_5746436_6 Cold shock K03704 - - 0.00000000000000000000000000000002595 127.0
HKD1_k127_5746436_7 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000000003867 110.0
HKD1_k127_5746436_8 - - - - 0.00000000004738 68.0
HKD1_k127_5746436_9 regulation of response to stimulus K14767,K16175 - - 0.0000000003163 74.0
HKD1_k127_5754824_0 Peptidase family M28 - - - 1.799e-212 675.0
HKD1_k127_5754824_1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 6.519e-197 642.0
HKD1_k127_5754824_10 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 318.0
HKD1_k127_5754824_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 304.0
HKD1_k127_5754824_12 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 300.0
HKD1_k127_5754824_13 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004758 287.0
HKD1_k127_5754824_14 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001293 278.0
HKD1_k127_5754824_15 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02407,K02492,K10714,K15671 GO:0005575,GO:0005623,GO:0008150,GO:0009288,GO:0040007,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000005079 255.0
HKD1_k127_5754824_16 PFAM Glycosyl transferase, group 1 K08256 - 2.4.1.345 0.00000000000000000000000000000000000000000000000000000000000000000000186 249.0
HKD1_k127_5754824_17 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000001505 243.0
HKD1_k127_5754824_18 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000001323 192.0
HKD1_k127_5754824_19 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000002122 189.0
HKD1_k127_5754824_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003542 534.0
HKD1_k127_5754824_20 lysyltransferase activity K07027 - - 0.0000000000000000000000000000000000000000000007314 179.0
HKD1_k127_5754824_21 peroxidase activity K09162 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016701,GO:0016702,GO:0042597,GO:0044464,GO:0050587,GO:0051213,GO:0055114 1.13.11.49 0.000000000000000000000000000000000000000003077 165.0
HKD1_k127_5754824_22 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000000000000000000000000000000000000000822 168.0
HKD1_k127_5754824_23 PFAM Cupin 2 conserved barrel domain protein - - - 0.00000000000000000000000000000000000000004481 156.0
HKD1_k127_5754824_24 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000005955 149.0
HKD1_k127_5754824_25 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K07291 - 2.7.8.34 0.0000000000000000000000002359 115.0
HKD1_k127_5754824_26 - - - - 0.00000000000000000000003298 108.0
HKD1_k127_5754824_27 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.00000002729 66.0
HKD1_k127_5754824_3 Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008783 479.0
HKD1_k127_5754824_4 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 444.0
HKD1_k127_5754824_5 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 409.0
HKD1_k127_5754824_6 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 396.0
HKD1_k127_5754824_7 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007352 367.0
HKD1_k127_5754824_8 Elongator protein 3, MiaB family, Radical SAM K22226,K22227 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 366.0
HKD1_k127_5754824_9 PFAM Ribulose bisphosphate carboxylase large K01601 - 4.1.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002918 342.0
HKD1_k127_5765475_0 Transglycosylase K05366 - 2.4.1.129,3.4.16.4 7.558e-228 726.0
HKD1_k127_5765475_1 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 556.0
HKD1_k127_5765475_10 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004175 294.0
HKD1_k127_5765475_11 Amidohydrolase family K12960,K20810 - 3.5.4.28,3.5.4.31,3.5.4.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003279 287.0
HKD1_k127_5765475_12 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000000000000000000009025 235.0
HKD1_k127_5765475_13 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000000002298 160.0
HKD1_k127_5765475_14 - - - - 0.0000000000000000000000381 110.0
HKD1_k127_5765475_2 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 531.0
HKD1_k127_5765475_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 437.0
HKD1_k127_5765475_4 OST-HTH/LOTUS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 381.0
HKD1_k127_5765475_5 N-terminal TM domain of oligopeptide transport permease C K02034,K15582 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007114 344.0
HKD1_k127_5765475_6 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 329.0
HKD1_k127_5765475_7 4Fe-4S single cluster domain K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 309.0
HKD1_k127_5765475_8 surface antigen K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006246 318.0
HKD1_k127_5765475_9 HNH nucleases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004549 286.0
HKD1_k127_5798793_0 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008042 564.0
HKD1_k127_5798793_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001993 434.0
HKD1_k127_5798793_2 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 409.0
HKD1_k127_5798793_3 Probable molybdopterin binding domain K03831 - 2.7.7.75 0.00000000000000000000000000000000000000000000000002766 183.0
HKD1_k127_5798793_4 - - - - 0.00000000000000000000000000000000000000009052 160.0
HKD1_k127_5798793_5 diguanylate cyclase K13590 - 2.7.7.65 0.000000000000000000000000000001106 139.0
HKD1_k127_5798793_6 Thioesterase K07107 - - 0.000000000000000000000000008184 113.0
HKD1_k127_5798793_7 Helix-turn-helix domain - - - 0.00000000000000000005929 98.0
HKD1_k127_5864402_0 Carbohydrate family 9 binding domain-like - - - 2.676e-291 918.0
HKD1_k127_5864402_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 9.499e-243 757.0
HKD1_k127_5864402_10 peptidyl-tyrosine sulfation K13992 - - 0.00000000000000000000000000000000000000000000000002492 190.0
HKD1_k127_5864402_11 - - - - 0.0000000000000001878 91.0
HKD1_k127_5864402_12 - - - - 0.00000000000001016 85.0
HKD1_k127_5864402_13 - - - - 0.0000003456 61.0
HKD1_k127_5864402_2 PFAM Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008542 608.0
HKD1_k127_5864402_3 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 604.0
HKD1_k127_5864402_4 C-terminus of AA_permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006561 530.0
HKD1_k127_5864402_5 Domain of unknown function (DUF4010) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 367.0
HKD1_k127_5864402_6 DHH family K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 311.0
HKD1_k127_5864402_7 Phosphoesterase family K21302 - 3.1.3.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008841 279.0
HKD1_k127_5864402_8 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004056 265.0
HKD1_k127_5864402_9 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000001314 208.0
HKD1_k127_5943869_0 abc transporter atp-binding protein K06147 - - 2.725e-219 697.0
HKD1_k127_5943869_1 Peptidase S46 - GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005575,GO:0005576,GO:0005623,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008239,GO:0009056,GO:0009279,GO:0009986,GO:0009987,GO:0016020,GO:0016049,GO:0016787,GO:0017171,GO:0019538,GO:0019867,GO:0030154,GO:0030312,GO:0030313,GO:0031975,GO:0032502,GO:0033218,GO:0034641,GO:0040007,GO:0042277,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044462,GO:0044464,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048869,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 2.17e-199 642.0
HKD1_k127_5943869_10 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000002619 171.0
HKD1_k127_5943869_11 - - - - 0.00000000000000000000000000000000000000005795 155.0
HKD1_k127_5943869_12 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) K12944 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0047429,GO:0047840 - 0.000000000000000000000000000000000005011 141.0
HKD1_k127_5943869_13 - - - - 0.0000000000000000007349 98.0
HKD1_k127_5943869_2 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006619 514.0
HKD1_k127_5943869_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 379.0
HKD1_k127_5943869_4 aminopeptidase K01256 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004205 381.0
HKD1_k127_5943869_5 very-long-chain-acyl-CoA dehydrogenase activity K00847 - 2.7.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002517 293.0
HKD1_k127_5943869_6 translation initiation factor activity K06996 - - 0.00000000000000000000000000000000000000000000000000000000000000000007715 241.0
HKD1_k127_5943869_7 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000001699 226.0
HKD1_k127_5943869_8 AntiSigma factor - - - 0.000000000000000000000000000000000000000000000000002617 194.0
HKD1_k127_5943869_9 translation initiation factor activity K06996 - - 0.000000000000000000000000000000000000000000000000004288 188.0
HKD1_k127_5946224_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 564.0
HKD1_k127_5946224_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 520.0
HKD1_k127_5946224_2 Fibronectin type 3 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 516.0
HKD1_k127_5946224_3 Peptidase family S58 K01266 - 3.4.11.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 462.0
HKD1_k127_5946224_4 Coenzyme A transferase K01039 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006836 406.0
HKD1_k127_5946224_5 Aminotransferase class-III K03851,K15372 - 2.6.1.55,2.6.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003829 394.0
HKD1_k127_5946224_6 Coenzyme A transferase K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 331.0
HKD1_k127_5946224_7 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000001344 253.0
HKD1_k127_5946224_9 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.000000003417 59.0
HKD1_k127_5969625_0 MMPL family K03296 - - 0.0 1137.0
HKD1_k127_5969625_1 CarboxypepD_reg-like domain - - - 1.668e-208 683.0
HKD1_k127_5969625_10 MASE1 domain protein K07216 - - 0.0000000000000000000000000000000000000000000000000000000002401 221.0
HKD1_k127_5969625_11 Domain of unknown function (DUF4112) - - - 0.00000000000000000000000000000000005659 139.0
HKD1_k127_5969625_12 PFAM SH3, type 3 - - - 0.00000000000000002911 92.0
HKD1_k127_5969625_13 - - - - 0.000000000000185 84.0
HKD1_k127_5969625_2 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 9.186e-204 668.0
HKD1_k127_5969625_3 Domain of unknown function (DUF3471) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004264 492.0
HKD1_k127_5969625_4 MatE K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 379.0
HKD1_k127_5969625_5 Zn_pept - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 366.0
HKD1_k127_5969625_6 Cache domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006094 289.0
HKD1_k127_5969625_7 Biotin-lipoyl like K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006562 281.0
HKD1_k127_5969625_8 SusD family K21572 - - 0.0000000000000000000000000000000000000000000000000000000000000007538 246.0
HKD1_k127_5969625_9 - - - - 0.00000000000000000000000000000000000000000000000000000000001846 215.0
HKD1_k127_6032820_0 oligopeptide transporter, OPT family - - - 4.256e-202 657.0
HKD1_k127_6032820_1 Protein of unknown function, DUF255 K06888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 556.0
HKD1_k127_6032820_10 C-terminal AAA-associated domain K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 342.0
HKD1_k127_6032820_11 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000004159 268.0
HKD1_k127_6032820_12 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000003342 255.0
HKD1_k127_6032820_13 Serine aminopeptidase, S33 K01259 - 3.4.11.5 0.000000000000000000000000000000000000000000000000000000000000000003122 239.0
HKD1_k127_6032820_14 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000004594 210.0
HKD1_k127_6032820_15 - - - - 0.000000000000000000000000000000000000000000000000000000001585 226.0
HKD1_k127_6032820_16 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000004152 211.0
HKD1_k127_6032820_17 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000008706 208.0
HKD1_k127_6032820_18 Fibronectin type 3 domain - - - 0.0000000000000000000000000000000000000000000000000000001921 223.0
HKD1_k127_6032820_19 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000004203 216.0
HKD1_k127_6032820_2 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 521.0
HKD1_k127_6032820_20 ATPases associated with a variety of cellular activities K16786,K16787 - - 0.0000000000000000000000000000000000000000000000000001101 201.0
HKD1_k127_6032820_21 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000001124 199.0
HKD1_k127_6032820_22 Cupin 2, conserved barrel - - - 0.0000000000000000000000000000000000000000000001105 170.0
HKD1_k127_6032820_23 PFAM ABC transporter related K16786,K16787 - - 0.0000000000000000000000000000000000000000000001372 179.0
HKD1_k127_6032820_24 HEAT repeats - - - 0.00000000000000000000000000000000004332 154.0
HKD1_k127_6032820_25 GAF domain-containing protein K08968 - 1.8.4.14 0.00000000000000000000001256 109.0
HKD1_k127_6032820_26 Cobalt transport protein K16785 - - 0.00000000000000000002344 99.0
HKD1_k127_6032820_28 ECF transporter, substrate-specific component K16923 - - 0.0000000000000002706 91.0
HKD1_k127_6032820_29 PFAM FecR protein - - - 0.00006934 57.0
HKD1_k127_6032820_3 DNA polymerase alpha chain like domain K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 509.0
HKD1_k127_6032820_4 Aminotransferase class I and II K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004618 475.0
HKD1_k127_6032820_5 Multicopper oxidase K22348 - 1.16.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003575 471.0
HKD1_k127_6032820_6 PFAM peptidase M18 aminopeptidase I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 413.0
HKD1_k127_6032820_7 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 392.0
HKD1_k127_6032820_8 Peptidase dimerisation domain K01436 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 378.0
HKD1_k127_6032820_9 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003664 329.0
HKD1_k127_6034560_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 1.408e-244 768.0
HKD1_k127_6034560_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 3.294e-228 759.0
HKD1_k127_6034560_10 peptidase - - - 0.00000000000000000000000000000000000000000000000000000000007315 225.0
HKD1_k127_6034560_11 PPIC-type PPIASE domain K03770 - 5.2.1.8 0.0000000000000000000000000000000000000001726 168.0
HKD1_k127_6034560_12 Pyridoxal phosphate biosynthetic protein PdxA K00097 - 1.1.1.262 0.0000000000000000000000000000000000007118 146.0
HKD1_k127_6034560_13 Aerotolerance regulator N-terminal - - - 0.00000000000000000005081 106.0
HKD1_k127_6034560_14 cell adhesion involved in biofilm formation - - - 0.00000000000002572 86.0
HKD1_k127_6034560_15 - - - - 0.0000000000000523 77.0
HKD1_k127_6034560_2 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 466.0
HKD1_k127_6034560_3 ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005571 397.0
HKD1_k127_6034560_4 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 339.0
HKD1_k127_6034560_5 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006360,GO:0006363,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0018130,GO:0019438,GO:0030312,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 327.0
HKD1_k127_6034560_6 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 331.0
HKD1_k127_6034560_7 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002429 297.0
HKD1_k127_6034560_8 SurA N-terminal domain K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000004809 267.0
HKD1_k127_6034560_9 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001613 254.0
HKD1_k127_6081869_0 Peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008872 554.0
HKD1_k127_6081869_1 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 562.0
HKD1_k127_6081869_10 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 284.0
HKD1_k127_6081869_11 Stage II sporulation protein K06381 - - 0.000000000000000000000000000000000000000000000000000000000000000000005769 250.0
HKD1_k127_6081869_12 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000002686 230.0
HKD1_k127_6081869_13 Carbon-nitrogen hydrolase K03820 - - 0.000000000000000000000000000000000000000000000000000000000000001956 244.0
HKD1_k127_6081869_14 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.00000000000000000000000000000000000000000000000000000000000001209 222.0
HKD1_k127_6081869_15 - - - - 0.0000000000000000000000000000000000000000000000000007372 208.0
HKD1_k127_6081869_16 Permease MlaE K02066 - - 0.00000000000000000000000000000000004514 144.0
HKD1_k127_6081869_17 Curli production assembly/transport component CsgG - - - 0.00000000000000000000000000000000435 138.0
HKD1_k127_6081869_18 Aerotolerance regulator N-terminal - - - 0.000000000000000000000000000001492 135.0
HKD1_k127_6081869_19 membrane transporter protein K07090 - - 0.000000000000000000000000001637 122.0
HKD1_k127_6081869_2 Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006381 517.0
HKD1_k127_6081869_20 abc transporter atp-binding protein K02065 - - 0.000000000000000006959 93.0
HKD1_k127_6081869_21 Amino-transferase class IV K00826 - 2.6.1.42 0.000000000000008672 86.0
HKD1_k127_6081869_22 ankyrin 3, node of Ranvier (ankyrin G) - - - 0.00000000000007641 80.0
HKD1_k127_6081869_24 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.0001161 55.0
HKD1_k127_6081869_3 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 496.0
HKD1_k127_6081869_4 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 465.0
HKD1_k127_6081869_5 PFAM Prenyltransferase squalene oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004629 355.0
HKD1_k127_6081869_6 Putative neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 354.0
HKD1_k127_6081869_7 Belongs to the bacterial solute-binding protein 9 family K02077,K09815,K09818 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 359.0
HKD1_k127_6081869_8 Homoserine dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 345.0
HKD1_k127_6081869_9 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 317.0
HKD1_k127_620830_0 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide - - - 3.371e-234 750.0
HKD1_k127_620830_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 524.0
HKD1_k127_620830_2 prohibitin homologues - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005073 416.0
HKD1_k127_620830_3 Inhibitor of apoptosis-promoting Bax1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002241 257.0
HKD1_k127_620830_4 Putative adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002915 265.0
HKD1_k127_620830_5 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000004343 208.0
HKD1_k127_620830_6 epimerase - - - 0.000000000000000000000000000000000000000000000000000000002276 218.0
HKD1_k127_620830_7 S4 RNA-binding domain K04762 - - 0.0000000000000000000000000000001921 127.0
HKD1_k127_620830_8 NfeD-like C-terminal, partner-binding K07340 - - 0.00000000000000000005105 98.0
HKD1_k127_620830_9 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000000000000000006307 98.0
HKD1_k127_6226916_0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 1.106e-235 737.0
HKD1_k127_6226916_1 PFAM aminotransferase class V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 575.0
HKD1_k127_6226916_10 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005056 351.0
HKD1_k127_6226916_11 UbiA prenyltransferase family K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 298.0
HKD1_k127_6226916_12 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001083 274.0
HKD1_k127_6226916_13 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002453 271.0
HKD1_k127_6226916_14 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000005214 220.0
HKD1_k127_6226916_15 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000004481 215.0
HKD1_k127_6226916_16 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000003853 188.0
HKD1_k127_6226916_17 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000000000000009131 147.0
HKD1_k127_6226916_18 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000009223 151.0
HKD1_k127_6226916_19 - - - - 0.000003151 52.0
HKD1_k127_6226916_2 Cys/Met metabolism PLP-dependent enzyme K01758 - 4.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006763 515.0
HKD1_k127_6226916_20 chaperone-mediated protein folding - - - 0.0003027 52.0
HKD1_k127_6226916_21 Protein of unknown function (DUF2380) - - - 0.0006514 49.0
HKD1_k127_6226916_3 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 529.0
HKD1_k127_6226916_4 HpcH/HpaI aldolase/citrate lyase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 415.0
HKD1_k127_6226916_5 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 - 5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 410.0
HKD1_k127_6226916_6 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 395.0
HKD1_k127_6226916_7 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 379.0
HKD1_k127_6226916_8 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 385.0
HKD1_k127_6226916_9 Polysaccharide biosynthesis C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 366.0
HKD1_k127_6273989_0 4Fe-4S dicluster domain K00184 - - 3.208e-238 769.0
HKD1_k127_6273989_1 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 521.0
HKD1_k127_6273989_10 XdhC and CoxI family K07402 - - 0.0000000000000000000000000000000000000000000008621 179.0
HKD1_k127_6273989_11 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000953 158.0
HKD1_k127_6273989_12 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000000000007082 166.0
HKD1_k127_6273989_13 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.200,3.5.1.19,6.1.1.16 0.0000000000000000000000000000000000001331 159.0
HKD1_k127_6273989_14 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000002242 142.0
HKD1_k127_6273989_15 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000004563 130.0
HKD1_k127_6273989_16 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000008327 92.0
HKD1_k127_6273989_17 Copper binding proteins, plastocyanin/azurin family - - - 0.000000000008322 71.0
HKD1_k127_6273989_18 von Willebrand factor type A domain K07114 - - 0.0000002014 63.0
HKD1_k127_6273989_2 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004609 355.0
HKD1_k127_6273989_3 dihydroorotate dehydrogenase activity K00226,K17723 - 1.3.1.1,1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 302.0
HKD1_k127_6273989_4 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 297.0
HKD1_k127_6273989_5 Heparinase II/III-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003567 259.0
HKD1_k127_6273989_6 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.000000000000000000000000000000000000000000000000000000000000001685 232.0
HKD1_k127_6273989_7 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000006119 228.0
HKD1_k127_6273989_8 Dihydrodipicolinate synthetase family - - - 0.0000000000000000000000000000000000000000000000000000000000004306 223.0
HKD1_k127_6273989_9 Pfam Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000002757 205.0
HKD1_k127_6308759_0 Dipeptidyl peptidase IV (DPP IV) N-terminal region K01278 - 3.4.14.5 2.748e-317 989.0
HKD1_k127_6308759_1 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 4.028e-282 885.0
HKD1_k127_6308759_10 radical SAM domain protein K06139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006648 441.0
HKD1_k127_6308759_11 Anthranilate synthase component I, N terminal region K01657,K01665 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 449.0
HKD1_k127_6308759_12 ATP-grasp domain K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 391.0
HKD1_k127_6308759_13 Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT) K00672 GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0030270,GO:0043446,GO:0044237,GO:0044281,GO:0071704 2.3.1.101 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 339.0
HKD1_k127_6308759_14 Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT K01499 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009987,GO:0015947,GO:0016787,GO:0016810,GO:0016814,GO:0018759,GO:0019238,GO:0043446,GO:0044237,GO:0044424,GO:0044464,GO:0071704 3.5.4.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 322.0
HKD1_k127_6308759_15 Belongs to the RimK family K05827,K05844 - 6.3.2.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006066 302.0
HKD1_k127_6308759_16 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003068 293.0
HKD1_k127_6308759_17 SusD family K21572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006591 291.0
HKD1_k127_6308759_18 transferase activity, transferring glycosyl groups K06984 - 2.4.2.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000985 285.0
HKD1_k127_6308759_19 PFAM Methylene-tetrahydromethanopterin dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008935 273.0
HKD1_k127_6308759_2 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 2.438e-280 877.0
HKD1_k127_6308759_20 Bacterial extracellular solute-binding proteins, family 3 K16254 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001817 257.0
HKD1_k127_6308759_21 ATP-grasp domain K01499,K06913 - 3.5.4.27 0.0000000000000000000000000000000000000000000000000000000000000000000000001876 261.0
HKD1_k127_6308759_22 protein related to plant photosystem II stability assembly factor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001695 260.0
HKD1_k127_6308759_23 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003056 252.0
HKD1_k127_6308759_24 May be involved in the transport of PQQ or its precursor to the periplasm - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004687 251.0
HKD1_k127_6308759_25 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001372 241.0
HKD1_k127_6308759_26 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000003046 241.0
HKD1_k127_6308759_27 CO2 hydration protein (ChpXY) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001671 253.0
HKD1_k127_6308759_28 PFAM Formaldehyde-activating enzyme (Fae) K10713 - 4.2.1.147 0.0000000000000000000000000000000000000000000000000000000000000000002709 234.0
HKD1_k127_6308759_29 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664,K13497 - 2.4.2.18,2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000005799 242.0
HKD1_k127_6308759_3 Serine hydrolase (FSH1) - - - 1.006e-243 765.0
HKD1_k127_6308759_30 Peptidase M15 - - - 0.000000000000000000000000000000000000000000000000000000000000000002259 239.0
HKD1_k127_6308759_31 formylmethanofuran dehydrogenase, subunit K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000386 231.0
HKD1_k127_6308759_32 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.00000000000000000000000000000000000000000000000000000000002817 221.0
HKD1_k127_6308759_33 Protein of unknown function (DUF447) K09154 - - 0.00000000000000000000000000000000000000000000000000001493 196.0
HKD1_k127_6308759_34 triphosphoribosyl-dephospho-CoA synthase activity K05964,K05966,K13927,K13930 - 2.4.2.52,2.7.7.61 0.000000000000000000000000000000000000000000000275 185.0
HKD1_k127_6308759_35 - - - - 0.000000000000000000000000000000000000000000002006 170.0
HKD1_k127_6308759_36 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000007334 172.0
HKD1_k127_6308759_37 Transcription elongation factor, N-terminal K03624 - - 0.00000000000000000000000000000000000000000005194 166.0
HKD1_k127_6308759_38 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000000000001265 162.0
HKD1_k127_6308759_39 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.000000000000000000000000000000000000000007834 164.0
HKD1_k127_6308759_4 CarboxypepD_reg-like domain - - - 4.569e-231 750.0
HKD1_k127_6308759_40 Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins K07400 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010467,GO:0015976,GO:0016043,GO:0016226,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0050896,GO:0051186,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564 - 0.0000000000000000000000000000000000000004823 155.0
HKD1_k127_6308759_41 COG0720 6-pyruvoyl-tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000298 152.0
HKD1_k127_6308759_42 - - - - 0.000000000000000000000000000000000000004315 156.0
HKD1_k127_6308759_43 - - - - 0.000000000000000000000000000000000004152 145.0
HKD1_k127_6308759_44 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000002093 140.0
HKD1_k127_6308759_45 lyase activity K09733 - 4.2.3.153 0.0000000000000000000000000000000003686 140.0
HKD1_k127_6308759_46 formylmethanofuran dehydrogenase activity K00202 GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281 1.2.7.12 0.0000000000000000000000000000000004121 147.0
HKD1_k127_6308759_47 Pentapeptide repeats (9 copies) - - - 0.00000000000000000000000000000000435 138.0
HKD1_k127_6308759_48 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000003443 130.0
HKD1_k127_6308759_49 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000002432 124.0
HKD1_k127_6308759_5 PQQ-like domain K00114 - 1.1.2.8 2.044e-216 687.0
HKD1_k127_6308759_50 - K01633,K07144 - 1.13.11.81,2.7.4.31,4.1.2.25,5.1.99.8 0.00000000000000000000000004716 124.0
HKD1_k127_6308759_51 methylamine metabolic process K03885,K16937 - 1.6.99.3,1.8.5.2 0.000000000000000000000000576 112.0
HKD1_k127_6308759_52 Glycosyltransferase family 87 - - - 0.00000000000000000000005135 113.0
HKD1_k127_6308759_53 Sulfur oxidation protein SoxY K17226 - - 0.0000000000000000000005272 102.0
HKD1_k127_6308759_54 pyrroloquinoline quinone biosynthesis protein D K06138 GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0018130,GO:0018189,GO:0018193,GO:0018212,GO:0019538,GO:0019752,GO:0034641,GO:0036211,GO:0042180,GO:0042181,GO:0042364,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072350,GO:0072351,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901661,GO:1901663 - 0.000000000000000001589 94.0
HKD1_k127_6308759_55 cytochrome - - - 0.00000000000000000483 94.0
HKD1_k127_6308759_56 EthD domain - - - 0.000000000000000008566 88.0
HKD1_k127_6308759_57 peroxiredoxin activity - - - 0.00000000000000001357 89.0
HKD1_k127_6308759_58 Glycogen recognition site of AMP-activated protein kinase - - - 0.00000000000000009087 93.0
HKD1_k127_6308759_59 YXWGXW repeat (2 copies) - - - 0.000000000000001497 80.0
HKD1_k127_6308759_6 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 1.433e-215 698.0
HKD1_k127_6308759_60 Sulphur oxidation protein SoxZ K17227 - - 0.0000000000005561 73.0
HKD1_k127_6308759_61 - - - - 0.00000000001866 73.0
HKD1_k127_6308759_62 Domain of unknown function (DUF4382) - - - 0.00000000002377 76.0
HKD1_k127_6308759_63 Anti-sigma-K factor rskA - - - 0.0000000001357 70.0
HKD1_k127_6308759_64 Sigma-70, region 4 K03088 - - 0.0000006511 57.0
HKD1_k127_6308759_66 beta-galactosidase activity - - - 0.00002021 57.0
HKD1_k127_6308759_67 oxidation-reduction process - - - 0.00004465 55.0
HKD1_k127_6308759_68 Glycogen recognition site of AMP-activated protein kinase - - - 0.00005166 55.0
HKD1_k127_6308759_7 Formylmethanofuran dehydrogenase subunit A K00200 GO:0003674,GO:0003824,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0044237,GO:0044281 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 629.0
HKD1_k127_6308759_8 all-trans-retinol 13,14-reductase activity K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009301 555.0
HKD1_k127_6308759_9 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 464.0
HKD1_k127_6314571_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 2.792e-214 698.0
HKD1_k127_6314571_1 Ftsk_gamma K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000636 625.0
HKD1_k127_6314571_10 Polyprenyl synthetase K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006776 309.0
HKD1_k127_6314571_11 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009505 312.0
HKD1_k127_6314571_12 KR domain K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000012 247.0
HKD1_k127_6314571_13 alginic acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000009611 232.0
HKD1_k127_6314571_14 2-phosphosulpholactate phosphatase K05979 - 3.1.3.71 0.00000000000000000000000000000000000000000000000000000008328 205.0
HKD1_k127_6314571_15 SIS domain K03271 - 5.3.1.28 0.0000000000000000000000000000000000000000000000000000004531 210.0
HKD1_k127_6314571_16 ZIP Zinc transporter K07238,K16267 - - 0.0000000000000000000000000000000000000000000000000001339 208.0
HKD1_k127_6314571_17 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000004302 174.0
HKD1_k127_6314571_18 PcrB family K07094 - - 0.0000000000000000000000000000000000000000004544 171.0
HKD1_k127_6314571_19 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000005454 128.0
HKD1_k127_6314571_2 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 577.0
HKD1_k127_6314571_20 Uncharacterised protein family UPF0102 K07460 - - 0.00000000000000000000000000003791 123.0
HKD1_k127_6314571_21 Domain of unknown function (DUF4321) - - - 0.0000000000000000000000002814 107.0
HKD1_k127_6314571_22 Late embryogenesis abundant protein - - - 0.00000000000000000000001106 107.0
HKD1_k127_6314571_23 self proteolysis - - - 0.000000000000000000939 100.0
HKD1_k127_6314571_24 Tetratricopeptide repeat - - - 0.0000000000001117 84.0
HKD1_k127_6314571_25 Modulates RecA activity K03565 - - 0.00000000001947 73.0
HKD1_k127_6314571_26 protein secretion K03116 GO:0008150,GO:0040007 - 0.000000002229 61.0
HKD1_k127_6314571_27 - - - - 0.000002371 57.0
HKD1_k127_6314571_28 VanZ like family - - - 0.00002284 57.0
HKD1_k127_6314571_3 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 542.0
HKD1_k127_6314571_4 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006867 529.0
HKD1_k127_6314571_5 Fibronectin type 3 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 544.0
HKD1_k127_6314571_6 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 505.0
HKD1_k127_6314571_7 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007743 447.0
HKD1_k127_6314571_8 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 388.0
HKD1_k127_6314571_9 Creatinase/Prolidase N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 351.0
HKD1_k127_6346725_0 Putative carbohydrate binding domain K12373 - 3.2.1.52 1.893e-248 792.0
HKD1_k127_6346725_1 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 592.0
HKD1_k127_6346725_2 Glycosyl hydrolases family 16 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 397.0
HKD1_k127_6346725_3 myo-inosose-2 dehydratase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 323.0
HKD1_k127_6346725_4 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006207 262.0
HKD1_k127_6346725_5 DinB superfamily - - - 0.00000000000000000000000000000000000000000000000000000000001474 213.0
HKD1_k127_6346725_6 PFAM glycoside hydrolase family 1 K05350 - 3.2.1.21 0.0000000000000000000000000000000000000000000000000001952 192.0
HKD1_k127_6346725_7 RibD C-terminal domain - - - 0.0000000000000000000000000000000000000000000001707 178.0
HKD1_k127_6346725_8 Protein of unknown function (DUF1572) - - - 0.000000000000000000000000000000000000000000003763 169.0
HKD1_k127_6346725_9 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000002428 137.0
HKD1_k127_6411078_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.685e-290 916.0
HKD1_k127_6411078_1 formate-tetrahydrofolate ligase activity K01938 - 6.3.4.3 9.961e-210 672.0
HKD1_k127_6411078_10 PFAM Diacylglycerol kinase, catalytic - - - 0.000000000000000000000000000000000000000004424 166.0
HKD1_k127_6411078_11 endoribonuclease L-PSP K09022 - 3.5.99.10 0.0000000000000000000000000000000000008877 148.0
HKD1_k127_6411078_12 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000002686 117.0
HKD1_k127_6411078_13 Protein of unknown function (DUF503) K09764 - - 0.00000000000000000005474 92.0
HKD1_k127_6411078_14 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family - - - 0.000000004739 63.0
HKD1_k127_6411078_15 - - - - 0.000000323 63.0
HKD1_k127_6411078_16 Participates in both transcription termination and antitermination K02600 - - 0.00002798 48.0
HKD1_k127_6411078_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 355.0
HKD1_k127_6411078_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004946 319.0
HKD1_k127_6411078_4 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 297.0
HKD1_k127_6411078_5 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000011 296.0
HKD1_k127_6411078_6 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004253 303.0
HKD1_k127_6411078_7 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000001234 231.0
HKD1_k127_6411078_8 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000001061 218.0
HKD1_k127_6411078_9 Fibronectin type 3 domain - - - 0.0000000000000000000000000000000000000000000000002192 203.0
HKD1_k127_6532051_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138,K18307 - - 6.477e-318 1005.0
HKD1_k127_6532051_1 PFAM magnesium chelatase ChlI subunit K07391 - - 2.397e-196 626.0
HKD1_k127_6532051_10 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 339.0
HKD1_k127_6532051_11 Amidinotransferase K01482 - 3.5.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 304.0
HKD1_k127_6532051_12 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000218 320.0
HKD1_k127_6532051_13 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 300.0
HKD1_k127_6532051_14 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 313.0
HKD1_k127_6532051_15 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003303 286.0
HKD1_k127_6532051_16 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000006394 268.0
HKD1_k127_6532051_17 tRNA processing K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002301 250.0
HKD1_k127_6532051_18 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003765 248.0
HKD1_k127_6532051_19 creatininase K01470,K22232 - 3.5.2.10 0.000000000000000000000000000000000000000000000000000000000000000000004542 249.0
HKD1_k127_6532051_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 584.0
HKD1_k127_6532051_20 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000006623 246.0
HKD1_k127_6532051_21 polysaccharide catabolic process K03478 - 3.5.1.105 0.00000000000000000000000000000000000000000000000000000000000002086 232.0
HKD1_k127_6532051_22 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000008 204.0
HKD1_k127_6532051_23 Pyridoxal-phosphate dependent enzyme K05396 - 4.4.1.15 0.0000000000000000000000000000000000000000000000000000002663 214.0
HKD1_k127_6532051_24 Protein of unknown function (DUF664) - - - 0.00000000000000000000000000000000000000000000000000000863 198.0
HKD1_k127_6532051_25 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000001296 214.0
HKD1_k127_6532051_26 Putative tRNA binding domain K06878 - - 0.0000000000000000000000000000000000000005812 153.0
HKD1_k127_6532051_27 Outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000003543 164.0
HKD1_k127_6532051_28 helix_turn_helix ASNC type K03719 - - 0.000000000000000000000000001253 118.0
HKD1_k127_6532051_29 Alpha beta hydrolase - - - 0.000000000000000000000000003145 117.0
HKD1_k127_6532051_3 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 585.0
HKD1_k127_6532051_30 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000004835 121.0
HKD1_k127_6532051_31 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000007581 119.0
HKD1_k127_6532051_32 - - - - 0.0000000000000000000000007951 113.0
HKD1_k127_6532051_33 Listeria-Bacteroides repeat domain (List_Bact_rpt) - - - 0.00000000000003785 89.0
HKD1_k127_6532051_34 - - - - 0.0000000000001721 83.0
HKD1_k127_6532051_35 - - - - 0.00000000002864 72.0
HKD1_k127_6532051_36 SnoaL-like domain - - - 0.000000006042 64.0
HKD1_k127_6532051_37 Copper amine oxidase N-terminal domain - - - 0.00003279 59.0
HKD1_k127_6532051_4 glutamate decarboxylase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 564.0
HKD1_k127_6532051_5 Rhodanese Homology Domain K01069,K03797 - 3.1.2.6,3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 520.0
HKD1_k127_6532051_6 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009797 534.0
HKD1_k127_6532051_7 Peptidase dimerisation domain K01439,K13049 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 475.0
HKD1_k127_6532051_8 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. EgtE subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 364.0
HKD1_k127_6532051_9 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 331.0
HKD1_k127_6562837_0 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006598 503.0
HKD1_k127_6562837_1 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008517 449.0
HKD1_k127_6562837_2 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000604 174.0
HKD1_k127_6562837_3 Polysaccharide deacetylase - - - 0.000000000000000000000000275 118.0
HKD1_k127_657286_0 HELICc2 K03722 - 3.6.4.12 9.757e-271 859.0
HKD1_k127_657286_1 Aminotransferase class I and II K10206 - 2.6.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003828 472.0
HKD1_k127_657286_10 - - - - 0.0000000001695 72.0
HKD1_k127_657286_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 418.0
HKD1_k127_657286_3 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004012 353.0
HKD1_k127_657286_4 deaminated base DNA N-glycosylase activity K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008862 275.0
HKD1_k127_657286_5 Domain of unknown function (DUF305) - - - 0.00000000000000000000000000000000000000000000000000000000004674 214.0
HKD1_k127_657286_6 LVIVD repeat - - - 0.0000000000000000000000000000001006 130.0
HKD1_k127_657286_7 Protein of unknown function (DUF1698) - - - 0.00000000000000000003552 100.0
HKD1_k127_657286_8 Endoribonuclease L-PSP - - - 0.000000000000000000462 94.0
HKD1_k127_6723498_0 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 404.0
HKD1_k127_6723498_1 homoserine kinase activity K00823,K07250 - 2.6.1.19,2.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009078 337.0
HKD1_k127_6723498_2 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002063 284.0
HKD1_k127_6723498_3 MafB19-like deaminase - - - 0.0000000000000000000000000000000000000000000000000000000000000000005085 231.0
HKD1_k127_6723498_4 HAD-hyrolase-like K19270 - 3.1.3.23 0.00000000000000000000000000000000000000000000004253 177.0
HKD1_k127_6723498_5 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000001604 149.0
HKD1_k127_6723498_6 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000004636 138.0
HKD1_k127_6723498_7 - - - - 0.00000000062 64.0
HKD1_k127_6723498_8 Outer membrane protein beta-barrel domain - - - 0.00002906 54.0
HKD1_k127_6775683_0 Amidohydrolase family - - - 0.0 1159.0
HKD1_k127_6775683_1 Peptidase family M1 domain - - - 2.877e-238 751.0
HKD1_k127_6775683_10 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 409.0
HKD1_k127_6775683_11 NAD NADP transhydrogenase alpha subunit K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 398.0
HKD1_k127_6775683_12 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 378.0
HKD1_k127_6775683_13 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000526 373.0
HKD1_k127_6775683_14 copper resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 342.0
HKD1_k127_6775683_15 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 313.0
HKD1_k127_6775683_16 Binding-protein-dependent transport system inner membrane component K02011 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 299.0
HKD1_k127_6775683_17 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009116 316.0
HKD1_k127_6775683_18 Bacterial extracellular solute-binding protein K02012 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002231 293.0
HKD1_k127_6775683_19 ABC-type spermidine putrescine transport systems, ATPase components K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000392 275.0
HKD1_k127_6775683_2 Belongs to the citrate synthase family K01647 - 2.3.3.1 9.847e-214 671.0
HKD1_k127_6775683_20 Protein of unknown function, DUF488 - - - 0.000000000000000000000000000000000000000000000000000002193 196.0
HKD1_k127_6775683_21 translation initiation inhibitor, yjgF family K04782 - 4.2.99.21 0.000000000000000000000000000000000000000000000000009813 183.0
HKD1_k127_6775683_22 Thioredoxin-like domain K03672 - 1.8.1.8 0.00000000000000000000000000000000000000000000006431 174.0
HKD1_k127_6775683_23 redox protein regulator of disulfide bond formation K04063 - - 0.000000000000000000000000000000000005507 141.0
HKD1_k127_6775683_24 - - - - 0.00000000000000000000000000000000008799 140.0
HKD1_k127_6775683_25 - - - - 0.00000000000000000000000000000008477 128.0
HKD1_k127_6775683_26 mitochondrial respiratory chain complex IV assembly K14998 GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704,GO:0071944 - 0.00000000000000000000000000002772 128.0
HKD1_k127_6775683_27 Binding-protein-dependent transport system inner membrane component K02011 - - 0.00000000000000000000000003676 118.0
HKD1_k127_6775683_28 GIY-YIG catalytic domain K07461 - - 0.0000000000000000000000001955 107.0
HKD1_k127_6775683_29 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.00000000000000000000008093 104.0
HKD1_k127_6775683_3 Acyl-CoA dehydrogenase, N-terminal domain - - - 1.269e-211 676.0
HKD1_k127_6775683_30 - - - - 0.000000000000000001097 92.0
HKD1_k127_6775683_31 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.000000000000000002443 87.0
HKD1_k127_6775683_32 ABC transporter K01990,K09695 - - 0.000000000000000003072 87.0
HKD1_k127_6775683_33 TM2 domain - - - 0.000000000000008709 81.0
HKD1_k127_6775683_34 Phosphoribosyl transferase domain K07100 - - 0.0000001204 63.0
HKD1_k127_6775683_35 Glyoxalase-like domain - - - 0.000000312 59.0
HKD1_k127_6775683_4 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01761 - 4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004137 564.0
HKD1_k127_6775683_5 Oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009405 565.0
HKD1_k127_6775683_6 NAD(P) transhydrogenase beta subunit K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 542.0
HKD1_k127_6775683_7 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002798 514.0
HKD1_k127_6775683_8 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004946 456.0
HKD1_k127_6775683_9 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 415.0
HKD1_k127_678187_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1446.0
HKD1_k127_678187_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1110.0
HKD1_k127_678187_10 Barrel-sandwich domain of CusB or HlyD membrane-fusion K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000005741 240.0
HKD1_k127_678187_11 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000002043 243.0
HKD1_k127_678187_12 domain, Protein K01179,K07260,K13735 - 3.2.1.4,3.4.17.14 0.0000000000000000000000000000000000000000000000000000000002762 223.0
HKD1_k127_678187_13 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000000004759 190.0
HKD1_k127_678187_14 - - - - 0.00000000000000000000000000000000000000000000008237 173.0
HKD1_k127_678187_15 EamA-like transporter family - - - 0.0000000000000000000000000000000000001909 153.0
HKD1_k127_678187_16 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000008724 145.0
HKD1_k127_678187_17 - - - - 0.0000000000000000000000000001795 126.0
HKD1_k127_678187_18 - - - - 0.000000000000000000000000578 116.0
HKD1_k127_678187_19 integral membrane protein K07027 - - 0.00000000000000000000003556 112.0
HKD1_k127_678187_2 malic enzyme K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 2.626e-264 834.0
HKD1_k127_678187_20 ABC-type multidrug transport system ATPase component - - - 0.0000000000000000000006068 110.0
HKD1_k127_678187_21 - - - - 0.0000000000000000000306 96.0
HKD1_k127_678187_22 - - - - 0.0000000000002085 79.0
HKD1_k127_678187_23 - - - - 0.0000000001709 68.0
HKD1_k127_678187_24 synthase K00232 - 1.3.3.6 0.00007255 53.0
HKD1_k127_678187_3 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 1.409e-229 722.0
HKD1_k127_678187_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 468.0
HKD1_k127_678187_5 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000703 416.0
HKD1_k127_678187_6 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001424 383.0
HKD1_k127_678187_7 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004678 327.0
HKD1_k127_678187_8 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 287.0
HKD1_k127_678187_9 Transglycosylase SLT domain K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009424 297.0
HKD1_k127_6889544_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 1.156e-320 994.0
HKD1_k127_6889544_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 556.0
HKD1_k127_6889544_2 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004815 422.0
HKD1_k127_6889544_3 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 348.0
HKD1_k127_6889544_4 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000007349 160.0
HKD1_k127_6889544_5 - - - - 0.00000000000123 71.0
HKD1_k127_6889544_6 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000001147 57.0
HKD1_k127_6925334_0 AcrB/AcrD/AcrF family K07787,K15726 - - 0.0 1106.0
HKD1_k127_6925334_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.00000000009533 64.0
HKD1_k127_6970933_0 Nicastrin K01301 - 3.4.17.21 9.937e-231 734.0
HKD1_k127_6970933_1 Enoyl-CoA hydratase K07539,K18570 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 411.0
HKD1_k127_6970933_10 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000003936 191.0
HKD1_k127_6970933_11 Enoyl-CoA hydratase/isomerase K07537 - 4.2.1.100 0.0000000000000000000000000000000000001474 161.0
HKD1_k127_6970933_12 peroxiredoxin activity K03564,K07638 - 1.11.1.15,2.7.13.3 0.0000000000000000000000000000000000001654 151.0
HKD1_k127_6970933_13 PFAM Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000001911 137.0
HKD1_k127_6970933_14 - - - - 0.0000000000000000006832 96.0
HKD1_k127_6970933_15 Domain of unknown function (DUF4405) - - - 0.000000000000000001417 96.0
HKD1_k127_6970933_16 - - - - 0.000000002796 64.0
HKD1_k127_6970933_17 - - - - 0.0000001514 57.0
HKD1_k127_6970933_18 Hemerythrin HHE cation binding domain - - - 0.000004676 57.0
HKD1_k127_6970933_2 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005474 408.0
HKD1_k127_6970933_3 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006187 388.0
HKD1_k127_6970933_4 S-(hydroxymethyl)glutathione dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003232 361.0
HKD1_k127_6970933_5 BadF/BadG/BcrA/BcrD ATPase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 321.0
HKD1_k127_6970933_7 Putative methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000001014 223.0
HKD1_k127_6970933_8 - - - - 0.00000000000000000000000000000000000000000000000000000000003983 216.0
HKD1_k127_6970933_9 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.00000000000000000000000000000000000000000000000000000006027 218.0
HKD1_k127_7011067_0 Alpha-L-rhamnosidase N-terminal domain K05989 - 3.2.1.40 0.0 1076.0
HKD1_k127_7011067_1 Zinc carboxypeptidase - - - 6.545e-249 790.0
HKD1_k127_7011067_10 Bacterial regulatory proteins, tetR family - - - 0.000000000000003943 83.0
HKD1_k127_7011067_11 Sugar-specific transcriptional regulator TrmB - - - 0.00000004357 63.0
HKD1_k127_7011067_2 3-isopropylmalate dehydratase activity K01681,K01703,K01704,K17749 - 4.2.1.3,4.2.1.33,4.2.1.35 7.385e-245 775.0
HKD1_k127_7011067_3 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 4.203e-241 767.0
HKD1_k127_7011067_4 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007193 469.0
HKD1_k127_7011067_5 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007204 341.0
HKD1_k127_7011067_6 Putative glycosyl hydrolase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001042 263.0
HKD1_k127_7011067_7 - - - - 0.00000000000000000000000000000000000000000000001583 184.0
HKD1_k127_7011067_8 pilus organization K07004 - - 0.00000000000000000000000000000000000000352 157.0
HKD1_k127_7011067_9 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000007749 152.0
HKD1_k127_7016951_0 cellulose binding - - - 0.0 1321.0
HKD1_k127_7016951_1 protein kinase activity - - - 2.002e-274 874.0
HKD1_k127_7016951_10 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000002187 121.0
HKD1_k127_7016951_11 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000009645 101.0
HKD1_k127_7016951_12 Kelch-like protein 17 K10454 GO:0000151,GO:0003674,GO:0003779,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006996,GO:0007010,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0008092,GO:0008150,GO:0009987,GO:0014069,GO:0015629,GO:0016043,GO:0019904,GO:0030029,GO:0030036,GO:0030425,GO:0031208,GO:0031461,GO:0031463,GO:0032279,GO:0032501,GO:0032502,GO:0032838,GO:0032839,GO:0032947,GO:0032991,GO:0036477,GO:0042995,GO:0043005,GO:0043025,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044297,GO:0044424,GO:0044444,GO:0044456,GO:0044463,GO:0044464,GO:0044877,GO:0045202,GO:0048513,GO:0048731,GO:0048856,GO:0051015,GO:0060322,GO:0071840,GO:0097447,GO:0097458,GO:0098794,GO:0098984,GO:0099568,GO:0099572,GO:0120025,GO:0120038,GO:0120111,GO:1902494,GO:1990234 - 0.0005454 52.0
HKD1_k127_7016951_2 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 1.19e-217 704.0
HKD1_k127_7016951_3 protein kinase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 615.0
HKD1_k127_7016951_4 Belongs to the type-B carboxylesterase lipase family K03929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 451.0
HKD1_k127_7016951_5 Beta-galactosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006664 386.0
HKD1_k127_7016951_6 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005159 333.0
HKD1_k127_7016951_7 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000171 149.0
HKD1_k127_7016951_8 negative regulation of transcription, DNA-templated - - - 0.00000000000000000000000000000000002687 137.0
HKD1_k127_7016951_9 - - - - 0.00000000000000000000000000003742 127.0
HKD1_k127_7053623_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000785 563.0
HKD1_k127_7053623_1 tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 556.0
HKD1_k127_7053623_10 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.0000000000000000000000000000000005835 138.0
HKD1_k127_7053623_11 - - - - 0.0000000000000000000000000000000961 138.0
HKD1_k127_7053623_12 COG1520 FOG WD40-like repeat - - - 0.000000000000009796 89.0
HKD1_k127_7053623_13 - - - - 0.00000000000003127 76.0
HKD1_k127_7053623_14 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K01848 - 5.4.99.2 0.000000003043 68.0
HKD1_k127_7053623_15 - - - - 0.0000004458 63.0
HKD1_k127_7053623_16 Late competence development protein ComFB - - - 0.000001178 60.0
HKD1_k127_7053623_2 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004988 567.0
HKD1_k127_7053623_3 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 477.0
HKD1_k127_7053623_4 Fructose-1-6-bisphosphatase, N-terminal domain K03841 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 433.0
HKD1_k127_7053623_5 Competence protein K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002982 354.0
HKD1_k127_7053623_6 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 300.0
HKD1_k127_7053623_7 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006656 271.0
HKD1_k127_7053623_8 MazG nucleotide pyrophosphohydrolase domain K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000003682 225.0
HKD1_k127_7053623_9 Uncharacterized protein family UPF0004 K18707 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000008532 228.0
HKD1_k127_7063626_0 Hydrolase CocE NonD family - - - 4.268e-308 957.0
HKD1_k127_7063626_1 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 597.0
HKD1_k127_7063626_10 Peptidase M16 inactive domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001674 258.0
HKD1_k127_7063626_11 Fibronectin type 3 domain - - - 0.00000000000000000000000000000000000000000000000000000000000001158 235.0
HKD1_k127_7063626_14 benzoyl-CoA oxygenase K15512 - 1.14.13.208 0.00000000000000000000000000000000000000000000000000000000008488 218.0
HKD1_k127_7063626_15 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000004872 182.0
HKD1_k127_7063626_16 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000001661 167.0
HKD1_k127_7063626_17 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000009587 157.0
HKD1_k127_7063626_18 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000008338 143.0
HKD1_k127_7063626_19 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000000000000000005807 136.0
HKD1_k127_7063626_2 Belongs to the aldehyde dehydrogenase family K00128,K00138 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 526.0
HKD1_k127_7063626_20 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000006096 132.0
HKD1_k127_7063626_21 Fibronectin type 3 domain - - - 0.00000000001787 73.0
HKD1_k127_7063626_22 - - - - 0.00000001122 66.0
HKD1_k127_7063626_23 domain, Protein - - - 0.000008774 50.0
HKD1_k127_7063626_3 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 491.0
HKD1_k127_7063626_4 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 400.0
HKD1_k127_7063626_5 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003983 386.0
HKD1_k127_7063626_6 amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000625 379.0
HKD1_k127_7063626_7 Ribonuclease E/G family K08301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008274 333.0
HKD1_k127_7063626_8 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 321.0
HKD1_k127_7063626_9 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 317.0
HKD1_k127_7113183_0 mismatched DNA binding K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.215e-225 732.0
HKD1_k127_7113183_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 567.0
HKD1_k127_7113183_10 HEAT repeats - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006964 326.0
HKD1_k127_7113183_11 Curli production assembly/transport component CsgG - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 299.0
HKD1_k127_7113183_12 Sigma-70 region 2 K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001512 254.0
HKD1_k127_7113183_13 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000003751 269.0
HKD1_k127_7113183_14 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009689 252.0
HKD1_k127_7113183_15 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000001144 211.0
HKD1_k127_7113183_16 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000004574 209.0
HKD1_k127_7113183_17 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000005709 148.0
HKD1_k127_7113183_18 PFAM Rhomboid family - - - 0.000000000000000000000000003062 123.0
HKD1_k127_7113183_19 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.00000000000000000000000001508 112.0
HKD1_k127_7113183_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 554.0
HKD1_k127_7113183_21 Ribosomal protein L34 K02914 - - 0.00000000000000000006234 90.0
HKD1_k127_7113183_22 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000535 91.0
HKD1_k127_7113183_23 - - - - 0.000000000001149 77.0
HKD1_k127_7113183_24 PFAM Formylglycine-generating sulfatase enzyme K20333 - - 0.00000005767 57.0
HKD1_k127_7113183_25 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000001343 59.0
HKD1_k127_7113183_26 tetratricopeptide repeat - - - 0.0001452 53.0
HKD1_k127_7113183_3 Domain in cystathionine beta-synthase and other proteins. K01697 - 4.2.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 557.0
HKD1_k127_7113183_4 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008961 413.0
HKD1_k127_7113183_5 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000981 401.0
HKD1_k127_7113183_6 Zn-dependent protease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006789 355.0
HKD1_k127_7113183_7 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008429 335.0
HKD1_k127_7113183_8 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002082 331.0
HKD1_k127_7113183_9 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006821 306.0
HKD1_k127_718135_0 protocatechuate 3,4-dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 460.0
HKD1_k127_718135_1 - - - - 0.00000000000000000000000000000000007748 151.0
HKD1_k127_7187127_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 0.0 1086.0
HKD1_k127_7187127_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.845e-276 874.0
HKD1_k127_7187127_10 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000001154 278.0
HKD1_k127_7187127_11 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000003814 264.0
HKD1_k127_7187127_12 PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000000000000000003105 235.0
HKD1_k127_7187127_13 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.0000000000000000000000000000000000000000000000000000000000000001963 244.0
HKD1_k127_7187127_14 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000001429 225.0
HKD1_k127_7187127_15 - - - - 0.000000000000000000000000000000000000000000000000000000000002778 216.0
HKD1_k127_7187127_16 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.000000000000000000000000000000000000000000001986 183.0
HKD1_k127_7187127_17 diguanylate cyclase - - - 0.0000000000000000000000000000002793 140.0
HKD1_k127_7187127_18 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000001464 95.0
HKD1_k127_7187127_19 Prokaryotic N-terminal methylation motif K02456,K02650,K02655 - - 0.000000000000003607 85.0
HKD1_k127_7187127_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003819 608.0
HKD1_k127_7187127_20 Transcription factor zinc-finger K09981 - - 0.000000000000005372 82.0
HKD1_k127_7187127_21 Yip1 domain - - - 0.000000003173 66.0
HKD1_k127_7187127_3 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 561.0
HKD1_k127_7187127_4 Adenylosuccinate lyase C-terminus K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009489 552.0
HKD1_k127_7187127_5 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 412.0
HKD1_k127_7187127_6 Polyphosphate kinase 2 (PPK2) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 404.0
HKD1_k127_7187127_7 phosphoribosylaminoimidazole-succinocarboxamide synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 389.0
HKD1_k127_7187127_8 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007675 294.0
HKD1_k127_7187127_9 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003456 271.0
HKD1_k127_7211207_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006957 445.0
HKD1_k127_7211207_1 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 420.0
HKD1_k127_7211207_2 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 405.0
HKD1_k127_7211207_3 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 402.0
HKD1_k127_7211207_4 TIGRFAM DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000001812 235.0
HKD1_k127_7211207_5 PFAM Histidine triad (HIT) protein K02503 - - 0.00000000000000000000000000000000000000757 147.0
HKD1_k127_7211207_6 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000225 139.0
HKD1_k127_7211207_7 Ribosomal protein S21 K02970 - - 0.00000000000000000000001983 100.0
HKD1_k127_722656_0 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 598.0
HKD1_k127_722656_1 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 486.0
HKD1_k127_722656_2 PFAM Mammalian cell entry related K06192 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009597 458.0
HKD1_k127_722656_3 ABC-type transport auxiliary lipoprotein component - - - 0.000000000000000000000000000000000000000000000000000000000001303 216.0
HKD1_k127_722656_4 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.000000000000000000000000008056 110.0
HKD1_k127_722656_5 Antibiotic biosynthesis monooxygenase - - - 0.0000000005043 68.0
HKD1_k127_722656_6 Sulfatase K01130 - 3.1.6.1 0.00007211 49.0
HKD1_k127_7241259_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 5.126e-313 987.0
HKD1_k127_7241259_1 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 469.0
HKD1_k127_7241259_10 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001025 259.0
HKD1_k127_7241259_11 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000003319 248.0
HKD1_k127_7241259_12 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000002489 239.0
HKD1_k127_7241259_13 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.00000000000000000000000000000000000000000000000000000000000001351 225.0
HKD1_k127_7241259_14 Ndr family - - - 0.00000000000000000000000000000000000000000000000000000000000008566 221.0
HKD1_k127_7241259_15 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000005576 218.0
HKD1_k127_7241259_16 Belongs to the MtfA family K09933 - - 0.000000000000000000000000000000000000000000000000000000007288 214.0
HKD1_k127_7241259_17 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000001449 202.0
HKD1_k127_7241259_18 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000005564 168.0
HKD1_k127_7241259_19 Tetratricopeptide repeat K08309 - - 0.0000000000000000000000000000000000000000004553 181.0
HKD1_k127_7241259_2 PFAM Rieske 2Fe-2S domain protein K00479,K00499 - 1.14.15.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 411.0
HKD1_k127_7241259_20 Cold shock K03704 - - 0.000000000000000000000000000000002558 129.0
HKD1_k127_7241259_21 Iron-sulfur cluster assembly protein - - - 0.000000000000000000000000000000004827 130.0
HKD1_k127_7241259_22 Matrixin - - - 0.000000000000000000000000000002098 131.0
HKD1_k127_7241259_23 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000006511 128.0
HKD1_k127_7241259_24 Prokaryotic N-terminal methylation motif - - - 0.0000000000000000000000000007508 120.0
HKD1_k127_7241259_25 - - - - 0.000000000000000000000006711 109.0
HKD1_k127_7241259_27 Bacterial regulatory proteins, tetR family - - - 0.0000000000001949 75.0
HKD1_k127_7241259_28 Protein conserved in bacteria - - - 0.000000000007344 71.0
HKD1_k127_7241259_3 Drug exporters of the RND superfamily K06994,K07003,K20466,K20470 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009273,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0040007,GO:0042546,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071766,GO:0071840,GO:0071944,GO:1901264 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 414.0
HKD1_k127_7241259_4 phosphorelay signal transduction system K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 392.0
HKD1_k127_7241259_5 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 351.0
HKD1_k127_7241259_6 3'-5' exonuclease K03684 - 3.1.13.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004985 344.0
HKD1_k127_7241259_7 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 324.0
HKD1_k127_7241259_8 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006375 297.0
HKD1_k127_7241259_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000022 272.0
HKD1_k127_7280080_0 Cupredoxin-like domain K00376 - 1.7.2.4 2.784e-270 844.0
HKD1_k127_7280080_1 PFAM ABC transporter related K13926 - - 8.199e-269 858.0
HKD1_k127_7280080_10 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 414.0
HKD1_k127_7280080_11 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 419.0
HKD1_k127_7280080_12 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 392.0
HKD1_k127_7280080_13 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008293 381.0
HKD1_k127_7280080_14 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005317 355.0
HKD1_k127_7280080_15 ErfK YbiS YcfS YnhG family protein K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004135 337.0
HKD1_k127_7280080_16 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 323.0
HKD1_k127_7280080_17 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 318.0
HKD1_k127_7280080_18 ABC transporter K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006756 275.0
HKD1_k127_7280080_19 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001164 267.0
HKD1_k127_7280080_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 7e-267 832.0
HKD1_k127_7280080_20 Barrel-sandwich domain of CusB or HlyD membrane-fusion K01993 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000125 259.0
HKD1_k127_7280080_21 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000000000000000000000002597 240.0
HKD1_k127_7280080_22 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000002613 235.0
HKD1_k127_7280080_23 phosphoribosyl transferase K07100 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000002751 228.0
HKD1_k127_7280080_24 Belongs to the Dps family K04047 - - 0.00000000000000000000000000000000000000000000000000000006231 202.0
HKD1_k127_7280080_25 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760,K04075,K15780 GO:0003674,GO:0003824,GO:0004422,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006188,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0043094,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046040,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0052657,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.8,6.3.4.19 0.000000000000000000000000000000000000000000000000000005937 196.0
HKD1_k127_7280080_26 Domain present in carbohydrate binding proteins and sugar hydrolses K07218 - - 0.00000000000000000000000000000000000000000000000000001533 213.0
HKD1_k127_7280080_27 lipoprotein involved in nitrous oxide reduction - - - 0.00000000000000000000000000000000000000000000000000003761 193.0
HKD1_k127_7280080_28 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000001868 178.0
HKD1_k127_7280080_29 Uncharacterized conserved protein (DUF2267) - - - 0.00000000000000000000000000000000000008553 149.0
HKD1_k127_7280080_3 Belongs to the peptidase S16 family - - - 4.534e-258 820.0
HKD1_k127_7280080_30 GYD domain - - - 0.000000000000000000000000000000000002428 147.0
HKD1_k127_7280080_31 ABC transporter K01990 - - 0.000000000000000000000000000000000007617 147.0
HKD1_k127_7280080_32 ABC-2 family transporter protein K19341 - - 0.0000000000000000000000001327 117.0
HKD1_k127_7280080_33 PFAM Cold-shock protein, DNA-binding - - - 0.00000000000000000000001509 105.0
HKD1_k127_7280080_34 COG1108 ABC-type Mn2 Zn2 transport systems, permease components K02075,K09816 - - 0.00000000000000000000003037 109.0
HKD1_k127_7280080_35 Transcriptional regulator - - - 0.00000000000000000000005718 108.0
HKD1_k127_7280080_36 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000172 96.0
HKD1_k127_7280080_37 F420H(2)-dependent quinone reductase - - - 0.00000000000000000002927 98.0
HKD1_k127_7280080_38 CBS domain K07182 - - 0.0000000000000000004816 92.0
HKD1_k127_7280080_39 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.0000000000000397 84.0
HKD1_k127_7280080_4 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 582.0
HKD1_k127_7280080_40 Cytochrome c - - - 0.0000000000001142 80.0
HKD1_k127_7280080_41 Belongs to the universal stress protein A family - - - 0.00000000001806 75.0
HKD1_k127_7280080_42 Domain of unknown function (DUF4136) - - - 0.000000000595 68.0
HKD1_k127_7280080_43 PFAM Archease protein family (DUF101 UPF0211) - - - 0.0000000007017 65.0
HKD1_k127_7280080_44 - - - - 0.00004328 51.0
HKD1_k127_7280080_45 PFAM CBS domain - - - 0.00005937 54.0
HKD1_k127_7280080_5 dna ligase K10747 GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 520.0
HKD1_k127_7280080_6 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005352 502.0
HKD1_k127_7280080_7 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00162,K11381 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001359 488.0
HKD1_k127_7280080_8 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 483.0
HKD1_k127_7280080_9 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 427.0
HKD1_k127_7357616_0 Sortilin, neurotensin receptor 3, - - - 1.7e-234 745.0
HKD1_k127_7357616_1 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007941 344.0
HKD1_k127_7357616_10 Diguanylate cyclase - - - 0.0000000000000000803 92.0
HKD1_k127_7357616_12 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00001164 54.0
HKD1_k127_7357616_2 Chromate resistance exported protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008996 299.0
HKD1_k127_7357616_3 Conserved hypothetical protein (DUF2461) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002061 292.0
HKD1_k127_7357616_4 cAMP biosynthetic process K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004695 287.0
HKD1_k127_7357616_5 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000132 274.0
HKD1_k127_7357616_6 Protein of unknown function (DUF421) - - - 0.0000000000000000000000000000000000000000001377 166.0
HKD1_k127_7357616_7 Protein of unknown function (DUF4242) - - - 0.00000000000000000000000007999 110.0
HKD1_k127_7357616_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000001171 119.0
HKD1_k127_7357616_9 DoxX - - - 0.00000000000000001251 92.0
HKD1_k127_7360942_0 phosphoribosylamine-glycine ligase activity K01945,K01955 - 6.3.4.13,6.3.5.5 3.474e-214 673.0
HKD1_k127_7360942_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005597 595.0
HKD1_k127_7360942_10 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 302.0
HKD1_k127_7360942_11 PFAM extracellular solute-binding protein family 1 K11069 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001115 273.0
HKD1_k127_7360942_12 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000007701 221.0
HKD1_k127_7360942_13 KR domain K07124 - - 0.0001872 49.0
HKD1_k127_7360942_2 Aminotransferase class-III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 560.0
HKD1_k127_7360942_3 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 419.0
HKD1_k127_7360942_4 lysine biosynthetic process via aminoadipic acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004034 428.0
HKD1_k127_7360942_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052,K11072 - 3.6.3.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 395.0
HKD1_k127_7360942_6 transmembrane transporter activity K13021 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007285 369.0
HKD1_k127_7360942_7 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 327.0
HKD1_k127_7360942_8 inner membrane component K11070 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 317.0
HKD1_k127_7360942_9 ABC-type spermidine putrescine transport system, permease component I K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 301.0
HKD1_k127_7426448_0 5TM C-terminal transporter carbon starvation CstA K06200 - - 8.929e-275 859.0
HKD1_k127_7426448_1 protein kinase activity - - - 2.847e-214 695.0
HKD1_k127_7426448_10 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 455.0
HKD1_k127_7426448_11 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009608 411.0
HKD1_k127_7426448_12 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 370.0
HKD1_k127_7426448_13 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 355.0
HKD1_k127_7426448_14 PFAM metallophosphoesterase K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 339.0
HKD1_k127_7426448_15 Electron transfer flavoprotein domain K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008235 317.0
HKD1_k127_7426448_16 Lactonase, 7-bladed beta-propeller - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 310.0
HKD1_k127_7426448_17 Electron transfer flavoprotein domain K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006472 299.0
HKD1_k127_7426448_18 Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 301.0
HKD1_k127_7426448_19 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004935 292.0
HKD1_k127_7426448_2 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor K00311 GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 1.554e-212 672.0
HKD1_k127_7426448_20 Biotin-lipoyl like K03543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003023 280.0
HKD1_k127_7426448_21 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005145 281.0
HKD1_k127_7426448_22 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001282 271.0
HKD1_k127_7426448_23 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009535 260.0
HKD1_k127_7426448_24 Major facilitator Superfamily K08223 - - 0.00000000000000000000000000000000000000000000000000000000000000000002741 247.0
HKD1_k127_7426448_25 Phospholipase/Carboxylesterase K06999 - - 0.000000000000000000000000000000000000000000000000000000000000000002544 236.0
HKD1_k127_7426448_26 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000000000001208 239.0
HKD1_k127_7426448_27 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000003575 232.0
HKD1_k127_7426448_28 Bacterial transcriptional repressor C-terminal K09017 - - 0.00000000000000000000000000000000000000000000000000000000000005144 220.0
HKD1_k127_7426448_29 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000002525 221.0
HKD1_k127_7426448_3 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 4.367e-203 637.0
HKD1_k127_7426448_30 MarC family integral membrane protein K05595 - - 0.0000000000000000000000000000000000000000000000000000001322 201.0
HKD1_k127_7426448_31 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000000000000000000003401 174.0
HKD1_k127_7426448_32 LVIVD repeat - - - 0.00000000000000000000000000000000000000003214 171.0
HKD1_k127_7426448_33 CoA binding domain K06929 - - 0.00000000000000000000000000000000000001669 149.0
HKD1_k127_7426448_34 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000005274 150.0
HKD1_k127_7426448_35 - - - - 0.0000000000000000000000000000000000002887 159.0
HKD1_k127_7426448_36 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000003255 149.0
HKD1_k127_7426448_37 Mannose-6-phosphate isomerase - - - 0.0000000000000000000000000000000000007348 152.0
HKD1_k127_7426448_38 4 iron, 4 sulfur cluster binding K02572,K02573 - - 0.000000000000000000000000000000001041 140.0
HKD1_k127_7426448_39 PFAM Endoribonuclease L-PSP - - - 0.000000000000000000000000000000002189 133.0
HKD1_k127_7426448_4 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 630.0
HKD1_k127_7426448_40 Transcriptional activator - - - 0.000000000000000000000000000000002446 151.0
HKD1_k127_7426448_41 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000002564 127.0
HKD1_k127_7426448_42 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.00000000000000000000002391 106.0
HKD1_k127_7426448_43 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000004776 100.0
HKD1_k127_7426448_44 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000008453 78.0
HKD1_k127_7426448_45 - - - - 0.00000000000003027 75.0
HKD1_k127_7426448_46 Protein of unknown function (DUF3307) - - - 0.00000000000003709 79.0
HKD1_k127_7426448_47 SatD family (SatD) - - - 0.000000002381 66.0
HKD1_k127_7426448_48 - - - - 0.0000872 50.0
HKD1_k127_7426448_49 function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex K02116 - - 0.0009344 46.0
HKD1_k127_7426448_5 Sugar (and other) transporter K03446 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003562 607.0
HKD1_k127_7426448_6 Involved in the tonB-independent uptake of proteins K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 553.0
HKD1_k127_7426448_7 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000926 460.0
HKD1_k127_7426448_8 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000046 448.0
HKD1_k127_7426448_9 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 433.0
HKD1_k127_7467582_0 RNA polymerase binding - - - 7.721e-315 1040.0
HKD1_k127_7467582_1 General secretory system II protein E domain protein K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 616.0
HKD1_k127_7467582_2 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 590.0
HKD1_k127_7467582_3 Type II secretion system (T2SS), protein F K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 554.0
HKD1_k127_7467582_4 PAS domain K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004848 415.0
HKD1_k127_7467582_5 Peptidase M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001196 242.0
HKD1_k127_7467582_6 Predicted permease YjgP/YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000409 243.0
HKD1_k127_7467582_7 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000001224 196.0
HKD1_k127_7467582_8 TIGRFAM competence protein ComEA helix-hairpin-helix repeat K02237 - - 0.0000000000000002212 84.0
HKD1_k127_7475636_0 Involved in the tonB-independent uptake of proteins - - - 1.574e-300 958.0
HKD1_k127_7475636_1 Required for chromosome condensation and partitioning K03529 - - 6.726e-270 881.0
HKD1_k127_7475636_10 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000000000000000003686 234.0
HKD1_k127_7475636_11 Belongs to the peptidase S8 family K14645 - - 0.000000000000000000000000000000000000000000000000000000000000001066 251.0
HKD1_k127_7475636_12 - - - - 0.000000000000000000000000000000000000000000000000000000000000001873 235.0
HKD1_k127_7475636_13 LytTr DNA-binding domain K02477 - - 0.00000000000000000000000000000000000000000000000000001245 198.0
HKD1_k127_7475636_14 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000000000006689 180.0
HKD1_k127_7475636_15 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.00000000000000000000000000000000000000000000002634 173.0
HKD1_k127_7475636_16 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.000000000000000000000000000000000000000009268 159.0
HKD1_k127_7475636_17 Subtilase family - - - 0.00000000000000000000000000000000000000004059 164.0
HKD1_k127_7475636_18 Binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000003152 161.0
HKD1_k127_7475636_19 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000547 167.0
HKD1_k127_7475636_2 lysine biosynthetic process via aminoadipic acid - - - 1.705e-197 644.0
HKD1_k127_7475636_20 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000005654 155.0
HKD1_k127_7475636_21 Thioredoxin-like domain K03671 - - 0.0000000000000000000000000000000000001035 151.0
HKD1_k127_7475636_22 Sporulation related domain - - - 0.0000000000000000000000000000000005766 148.0
HKD1_k127_7475636_23 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000003513 130.0
HKD1_k127_7475636_24 Histidine kinase - - - 0.0000000000000000000000000001176 128.0
HKD1_k127_7475636_25 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000001213 102.0
HKD1_k127_7475636_26 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.0000000000000000000002256 110.0
HKD1_k127_7475636_27 Sporulation related domain - - - 0.0000000000000000000315 104.0
HKD1_k127_7475636_28 Dodecin K09165 - - 0.0000000000000000001808 93.0
HKD1_k127_7475636_29 - - - - 0.000000000000000000604 102.0
HKD1_k127_7475636_3 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009513 637.0
HKD1_k127_7475636_30 - - - - 0.0000000000000001075 96.0
HKD1_k127_7475636_31 - - - - 0.00000000000000162 88.0
HKD1_k127_7475636_32 transport - - - 0.0000000002614 70.0
HKD1_k127_7475636_33 - - - - 0.0001423 54.0
HKD1_k127_7475636_4 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 466.0
HKD1_k127_7475636_5 Domain of unknown function (DUF4159) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 315.0
HKD1_k127_7475636_6 Dihydroxyacetone kinase family K07030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000404 318.0
HKD1_k127_7475636_7 nuclear chromosome segregation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002689 283.0
HKD1_k127_7475636_8 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000154 249.0
HKD1_k127_7475636_9 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000001657 231.0
HKD1_k127_7532956_0 X-Pro dipeptidyl-peptidase domain protein K06978 - - 7.773e-257 807.0
HKD1_k127_7532956_1 amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 518.0
HKD1_k127_7532956_2 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 488.0
HKD1_k127_7532956_3 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003493 415.0
HKD1_k127_7532956_4 Sodium/hydrogen exchanger family K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 334.0
HKD1_k127_7532956_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000001421 103.0
HKD1_k127_7532956_6 guanyl-nucleotide exchange factor activity K01179,K03929,K09612,K12287,K19701,K19702 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.2.1.4,3.4.11.10,3.4.11.24,3.4.11.6 0.000000000001012 82.0
HKD1_k127_7578763_0 Isocitrate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 554.0
HKD1_k127_7578763_1 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 444.0
HKD1_k127_7578763_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000182 434.0
HKD1_k127_7578763_3 Fibronectin type 3 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009048 404.0
HKD1_k127_7578763_4 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000003232 255.0
HKD1_k127_7578763_5 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000000000000000000000006766 235.0
HKD1_k127_7578763_6 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000001248 184.0
HKD1_k127_7578763_7 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.00000000000000000000000000000000000000000005872 179.0
HKD1_k127_7578763_8 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits - - - 0.00000000000000004548 82.0
HKD1_k127_7578763_9 TonB-dependent Receptor Plug Domain - - - 0.00000000000003918 86.0
HKD1_k127_7620225_0 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 582.0
HKD1_k127_7620225_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003825 570.0
HKD1_k127_7620225_2 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 543.0
HKD1_k127_7620225_3 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 514.0
HKD1_k127_7620225_4 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007828 488.0
HKD1_k127_7620225_5 Zinc dependent phospholipase C - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 356.0
HKD1_k127_7620225_6 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0046983,GO:0055114 - 0.00000000000000000000000006016 118.0
HKD1_k127_7620225_7 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000008451 113.0
HKD1_k127_7620225_8 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000001808 58.0
HKD1_k127_7637423_0 peptidyl-tyrosine sulfation - - - 0.0 1086.0
HKD1_k127_7637423_1 peptidyl-tyrosine sulfation - - - 7.612e-264 833.0
HKD1_k127_7637423_2 YdjC-like protein K03478 - 3.5.1.105 0.000000001872 62.0
HKD1_k127_7637423_3 peptidyl-tyrosine sulfation - - - 0.00003569 49.0
HKD1_k127_7690161_0 ABC transporter K06158 - - 2.629e-207 663.0
HKD1_k127_7690161_1 PFAM nucleoside H symporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 594.0
HKD1_k127_7690161_2 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 586.0
HKD1_k127_7690161_3 Ornithine cyclodeaminase/mu-crystallin family K01750,K18258 - 1.5.1.25,4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002085 385.0
HKD1_k127_7690161_4 Serine/threonine phosphatases, family 2C, catalytic domain K01090,K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007731 360.0
HKD1_k127_7690161_5 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 328.0
HKD1_k127_7690161_6 beta' subunit K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001609 286.0
HKD1_k127_7690161_7 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004125 248.0
HKD1_k127_7690161_8 Dienelactone hydrolase family - - - 0.00000000000000000000000000000000000000001316 163.0
HKD1_k127_7945372_0 N-Acetylmuramoyl-L-alanine amidase K01187 - 3.2.1.20 1.287e-265 833.0
HKD1_k127_7945372_1 Major Facilitator K16211 - - 4.848e-197 627.0
HKD1_k127_7945372_2 Glycogen debranching enzyme, glucanotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003148 388.0
HKD1_k127_7945372_3 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008052 367.0
HKD1_k127_7945372_4 hydrolase activity, hydrolyzing O-glycosyl compounds K01176 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.1 0.0000000000000000000000000000000000000000000000000000000001055 211.0
HKD1_k127_811453_0 Anthranilate synthase component I, N terminal region K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 491.0
HKD1_k127_811453_1 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 484.0
HKD1_k127_811453_10 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840 - 5.4.2.8 0.000000000000000001351 86.0
HKD1_k127_811453_2 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004449 399.0
HKD1_k127_811453_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003655 385.0
HKD1_k127_811453_4 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001037 288.0
HKD1_k127_811453_5 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000000000000003062 185.0
HKD1_k127_811453_6 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000153 169.0
HKD1_k127_811453_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000004829 158.0
HKD1_k127_811453_8 NUDIX domain K08310 - 3.6.1.67 0.000000000000000000000000000001136 128.0
HKD1_k127_811453_9 enzyme binding K00567,K07443 - 2.1.1.63 0.00000000000000000000002217 104.0
HKD1_k127_850790_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 2.606e-223 717.0
HKD1_k127_850790_1 Protein of unknown function (DUF512) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 472.0
HKD1_k127_850790_10 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000001278 237.0
HKD1_k127_850790_11 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000008129 225.0
HKD1_k127_850790_12 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000001482 202.0
HKD1_k127_850790_13 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000006692 200.0
HKD1_k127_850790_14 helix_turn_helix, mercury resistance - - - 0.0000000000000000000000000000000000000000001004 175.0
HKD1_k127_850790_15 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000001265 156.0
HKD1_k127_850790_16 Bacterial membrane protein, YfhO - - - 0.0000000000000000000000000000000002676 138.0
HKD1_k127_850790_17 Glycosyl transferase family 2 - - - 0.00000000000000000000000000008205 128.0
HKD1_k127_850790_18 Acylphosphatase K01512 - 3.6.1.7 0.000000000000002245 86.0
HKD1_k127_850790_19 chaperone-mediated protein folding - - - 0.0000000000000121 88.0
HKD1_k127_850790_2 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 434.0
HKD1_k127_850790_20 Tetratricopeptide repeat - - - 0.0000009785 59.0
HKD1_k127_850790_21 - - - - 0.00003934 46.0
HKD1_k127_850790_3 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004817 397.0
HKD1_k127_850790_4 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 358.0
HKD1_k127_850790_5 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 325.0
HKD1_k127_850790_6 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 328.0
HKD1_k127_850790_7 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K06898,K09121 - 4.99.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 317.0
HKD1_k127_850790_8 Biopterin-dependent aromatic amino acid hydroxylase K00500 - 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000013 271.0
HKD1_k127_850790_9 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009532 267.0
HKD1_k127_993629_0 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006988 516.0
HKD1_k127_993629_1 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 362.0
HKD1_k127_993629_2 - - - - 0.00000000000000000000000000000000000000000000000000000004088 199.0
HKD1_k127_993629_3 - - - - 0.000000000000000000000000000000000000000000002716 172.0
HKD1_k127_993629_4 - - - - 0.00000000000000000000000000000000000000003537 173.0
HKD1_k127_993629_5 methyltransferase activity - - - 0.00000000000000000000000000000000544 137.0
HKD1_k127_993629_6 Domain of unknown function (DU1801) - - - 0.00000000000000000000000000003238 120.0
HKD1_k127_993629_7 - - - - 0.0000000000003947 70.0
HKD1_k127_993629_8 - - - - 0.0000000003701 70.0
HKD1_k127_993629_9 Haloacid dehalogenase-like hydrolase K19270 - 3.1.3.23 0.0000001378 54.0