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Overview

ID MAG01772
Name HKD2_bin.103
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Desulfobacterota_B
Class Binatia
Order Binatales
Family Binataceae
Genus JAJPHI01
Species
Assembly information
Completeness (%) 57.53
Contamination (%) 1.01
GC content (%) 59.0
N50 (bp) 2,158
Genome size (bp) 1,708,416

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1993

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10005237_0 Conserved hypothetical protein (DUF2461) - - - 0.00000000000000000000000000000000000000000000000000000000000009647 220.0
HKD2_k127_10005237_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000004575 144.0
HKD2_k127_10005237_2 lysyltransferase activity K07027 - - 0.000000000000000000000000000962 125.0
HKD2_k127_10005237_3 Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP K19788 - - 0.0000000000000000393 87.0
HKD2_k127_10006105_0 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000005923 201.0
HKD2_k127_10006105_1 SnoaL-like domain - - - 0.000000184 56.0
HKD2_k127_10009005_0 Male sterility protein K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000004281 244.0
HKD2_k127_10009005_1 Dual specificity phosphatase, catalytic domain K14165 GO:0000272,GO:0001871,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005982,GO:0005983,GO:0006073,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009507,GO:0009536,GO:0009987,GO:0016052,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0030246,GO:0030247,GO:0042578,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046838,GO:0050308,GO:0071704,GO:1901575,GO:2001070 3.1.3.16,3.1.3.48 0.00000000000000000004049 96.0
HKD2_k127_10009005_2 - - - - 0.0008368 51.0
HKD2_k127_10013421_0 Phosphoesterase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006229 391.0
HKD2_k127_10013421_1 alcohol dehydrogenase (NAD) activity K00001,K00121,K02267,K13980,K18857 GO:0000302,GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009410,GO:0009413,GO:0009414,GO:0009415,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009737,GO:0009743,GO:0009744,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0014074,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0031000,GO:0032355,GO:0033993,GO:0034285,GO:0036270,GO:0036293,GO:0042221,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043279,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046686,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065007,GO:0070482,GO:0071944,GO:0080134,GO:0080135,GO:0097305,GO:1900037,GO:1900039,GO:1901698,GO:1901700 1.1.1.1,1.1.1.284 0.0000000000000000000000000000000000000000000000000000602 191.0
HKD2_k127_10024513_0 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000001157 241.0
HKD2_k127_10024513_1 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000008932 83.0
HKD2_k127_1004234_0 Transcriptional regulator - - - 0.000000000000000000000000000004547 125.0
HKD2_k127_1004234_1 Lumazine binding domain K00793 - 2.5.1.9 0.00000000000000000007464 92.0
HKD2_k127_10108417_0 PFAM von Willebrand factor type A K07114 - - 0.00000000000000000000005286 111.0
HKD2_k127_10108417_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0007322 46.0
HKD2_k127_10124922_0 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 361.0
HKD2_k127_10124922_1 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 325.0
HKD2_k127_10142181_0 ATPase-coupled phosphate ion transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000003843 177.0
HKD2_k127_10142181_1 Uncharacterised nucleotidyltransferase - - - 0.000000000000000000000000000000000002939 152.0
HKD2_k127_10142181_2 signal peptide processing K13280 - 3.4.21.89 0.000000005768 64.0
HKD2_k127_10143418_0 Glutathione S-transferase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000007742 234.0
HKD2_k127_10143418_1 PFAM aminoglycoside phosphotransferase K04343 - 2.7.1.72 0.000000000000000000000000000000000000006486 156.0
HKD2_k127_10143721_0 Domain of unknown function (DUF4870) - - - 0.00000000002386 69.0
HKD2_k127_10201144_0 Flavin-binding monooxygenase-like K03379,K18371 - 1.14.13.22,1.14.13.226 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 293.0
HKD2_k127_10206871_0 ErfK YbiS YcfS YnhG family protein K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 426.0
HKD2_k127_10206871_1 Putative cyclase - - - 0.000000000000000000000003132 104.0
HKD2_k127_1041783_0 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000001699 194.0
HKD2_k127_1041783_1 Ribosomal protein L11 methyltransferase K02687 - - 0.0000000000000000000000000000000006382 141.0
HKD2_k127_1041783_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0009153 44.0
HKD2_k127_1050531_0 AAA domain K02282 - - 0.000000000000000000000000000000006637 142.0
HKD2_k127_1050531_1 PFAM type II secretion system protein E K02283 - - 0.00000000000000000000000003944 112.0
HKD2_k127_1062127_0 - - - - 0.0000000000000000000000000000000000000000001422 171.0
HKD2_k127_1080491_0 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001669 238.0
HKD2_k127_1080491_1 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000116 214.0
HKD2_k127_1080491_2 PFAM 2-nitropropane dioxygenase NPD K00459 - 1.13.12.16 0.0000000000000000000000008488 108.0
HKD2_k127_1088409_0 GMP synthase (glutamine-hydrolyzing) activity K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000001979 248.0
HKD2_k127_1088409_1 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.000000000000000000000000000000000003189 142.0
HKD2_k127_1088409_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0050896 4.4.1.5 0.000000000000000000000000000499 118.0
HKD2_k127_1089425_0 PFAM PrkA AAA K07180 - - 0.0 1033.0
HKD2_k127_1089425_1 Protein of unknown function (DUF444) K09786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 537.0
HKD2_k127_1089425_2 SpoVR family K06415 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001755 444.0
HKD2_k127_1089425_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000003724 192.0
HKD2_k127_1115341_0 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000007273 160.0
HKD2_k127_1120565_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009733 362.0
HKD2_k127_1120565_1 Acyl dehydratase - - - 0.000000000000000000000000000000000000000000000002004 177.0
HKD2_k127_1120565_2 hydrolase, CocE NonD family K06978 - - 0.000000000000000004824 86.0
HKD2_k127_1132957_0 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000002867 99.0
HKD2_k127_1132957_1 Luciferase-like monooxygenase - - - 0.0000000000000000000003467 103.0
HKD2_k127_1161725_0 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000000000005862 199.0
HKD2_k127_1161725_1 PSP1 domain protein - - - 0.0000000000000000000000000000000000000000000001284 174.0
HKD2_k127_1161725_2 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000001728 151.0
HKD2_k127_1161725_3 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000005037 70.0
HKD2_k127_1174669_0 Protein of unknown function (DUF3341) - - - 0.0000000000003773 78.0
HKD2_k127_1174669_1 PFAM Polysulphide reductase, NrfD K00185 - - 0.000000009545 59.0
HKD2_k127_1174669_2 Pfam Polysulphide reductase, NrfD - - - 0.0001569 48.0
HKD2_k127_1177419_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000181 229.0
HKD2_k127_1177419_1 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000002261 93.0
HKD2_k127_1177811_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000001318 241.0
HKD2_k127_1177811_1 CDP-alcohol phosphatidyltransferase - - - 0.0000000000000000000000002291 113.0
HKD2_k127_1185967_0 O-methyltransferase K00588 - 2.1.1.104 0.0000000000000000000000000000000000000000000000000000000000000000000000007392 251.0
HKD2_k127_1185967_1 beta-keto acid cleavage enzyme - - - 0.00000000000000000000000000000001093 129.0
HKD2_k127_1185967_2 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000001977 120.0
HKD2_k127_1185967_3 - K07018 - - 0.000000000000000000000000002131 116.0
HKD2_k127_1188363_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 1.05e-200 654.0
HKD2_k127_1188363_1 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001146 255.0
HKD2_k127_1188363_2 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000001453 162.0
HKD2_k127_1188363_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000003051 153.0
HKD2_k127_1188363_4 Putative zinc-finger - - - 0.000391 51.0
HKD2_k127_1198564_0 Amidohydrolase family - - - 0.00000000000000000000000000000000001608 152.0
HKD2_k127_1198564_1 alpha-ribazole phosphatase activity - - - 0.00000000000000000000001151 104.0
HKD2_k127_1200338_0 Acetyl-CoA hydrolase/transferase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 312.0
HKD2_k127_1200338_1 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000154 140.0
HKD2_k127_1203891_0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K03496 GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 337.0
HKD2_k127_1203891_1 ParB-like nuclease domain K03497 - - 0.000000000000000000000000002988 115.0
HKD2_k127_1210784_0 COG2818 3-methyladenine DNA glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000966 279.0
HKD2_k127_1210784_1 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001004 289.0
HKD2_k127_1210784_2 L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000007601 102.0
HKD2_k127_1236993_0 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001649 273.0
HKD2_k127_1238058_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 533.0
HKD2_k127_1238058_1 Transcriptional regulator - - - 0.00000000000002892 75.0
HKD2_k127_1244305_0 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000002692 258.0
HKD2_k127_1246180_0 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000001194 265.0
HKD2_k127_1246180_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000001587 141.0
HKD2_k127_1246180_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0000000000000000000000000000004643 124.0
HKD2_k127_1253287_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 328.0
HKD2_k127_1253287_1 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000002057 128.0
HKD2_k127_1253287_2 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852,K00856 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 0.0000000000000000000000000005588 116.0
HKD2_k127_1264664_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 368.0
HKD2_k127_1264664_1 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000000000000001101 228.0
HKD2_k127_1264664_2 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000001103 223.0
HKD2_k127_1268336_0 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000002452 248.0
HKD2_k127_1268336_1 cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000001354 163.0
HKD2_k127_1268336_2 Protein of unknown function (DUF1329) - - - 0.0000004044 61.0
HKD2_k127_1284076_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 452.0
HKD2_k127_1284076_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 422.0
HKD2_k127_1285163_0 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005221 343.0
HKD2_k127_1285163_1 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000134 280.0
HKD2_k127_1285163_2 Cobalt transport protein K16785 - - 0.00000000000000000000000000000000000001484 154.0
HKD2_k127_1285163_3 PFAM YCII-related K09780 - - 0.000000000000000001188 88.0
HKD2_k127_1288944_0 PFAM NAD-dependent epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 557.0
HKD2_k127_1288944_1 - - - - 0.00000000000004363 77.0
HKD2_k127_1300217_0 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059,K21883 - 1.1.1.100,1.1.1.401 0.000000000000000000000000000000000000000000000000000000000000000001049 233.0
HKD2_k127_1300217_1 SnoaL-like domain - - - 0.00000000001078 72.0
HKD2_k127_1302239_0 Biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 526.0
HKD2_k127_1302239_1 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000483 123.0
HKD2_k127_1307796_0 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000009464 236.0
HKD2_k127_1307796_1 Belongs to the HpcH HpaI aldolase family K01644,K08691 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0009987,GO:0015977,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0043167,GO:0043169,GO:0043427,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046872,GO:0047777,GO:0050083,GO:0071704 4.1.3.24,4.1.3.25,4.1.3.34 0.0000000000000000000000000000000000000000000000008114 187.0
HKD2_k127_1312876_0 TIGRFAM Ammonium transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 545.0
HKD2_k127_1312876_1 Serine/threonine phosphatases, family 2C, catalytic domain - - - 0.0000000000000000000000000000003266 128.0
HKD2_k127_1322717_0 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K15726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007186 374.0
HKD2_k127_1322717_1 SMP-30/Gluconolaconase/LRE-like region K14274 - - 0.0000000000000000000000561 104.0
HKD2_k127_1342021_0 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000001017 202.0
HKD2_k127_1342021_1 2Fe-2S iron-sulfur cluster binding domain K04755 - - 0.000000000000000000000000000001275 125.0
HKD2_k127_1342021_2 Oxidoreductase NAD-binding domain K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000003657 114.0
HKD2_k127_1342021_3 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000003751 89.0
HKD2_k127_1342021_4 Signal transducing histidine kinase, homodimeric domain K03407 - 2.7.13.3 0.00001196 50.0
HKD2_k127_1358317_0 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 295.0
HKD2_k127_1358317_1 May be involved in the transport of PQQ or its precursor to the periplasm K06136 - - 0.00000000000000000000000000000000000000000000000000961 182.0
HKD2_k127_1358317_2 PTS HPr component phosphorylation site K11189 - - 0.00003241 48.0
HKD2_k127_1366955_0 COG1192 ATPases involved in chromosome partitioning K03496 - - 0.0000000000000000000000003032 113.0
HKD2_k127_1375345_0 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 298.0
HKD2_k127_1375345_1 PFAM magnesium chelatase ChlI subunit K07391 - - 0.0000000000000000000000000000000000000000000000000000000000003181 217.0
HKD2_k127_1375345_2 CoA-transferase family III - - - 0.0000000005304 61.0
HKD2_k127_1382349_0 PFAM acyl-CoA dehydrogenase domain protein K00255,K11731 - 1.3.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 312.0
HKD2_k127_1382349_1 SpoVT / AbrB like domain - - - 0.0000001166 54.0
HKD2_k127_1384617_0 Aminotransferase class I and II K00812,K10907 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005283 379.0
HKD2_k127_1384617_1 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0070566,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.00000000000000000000000000000000000000000000002053 175.0
HKD2_k127_1384617_2 Pfam:Methyltransf_26 K08316 - 2.1.1.171 0.00000000000000000000000000000006804 132.0
HKD2_k127_1406353_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001515 261.0
HKD2_k127_1406353_1 Alpha beta hydrolase - - - 0.0002298 44.0
HKD2_k127_1440315_0 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000001675 264.0
HKD2_k127_1440315_1 PQQ-like domain - - - 0.000000000000000001937 89.0
HKD2_k127_1444947_0 PFAM secretion protein HlyD family protein K01993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001888 284.0
HKD2_k127_1444947_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000002511 162.0
HKD2_k127_1445301_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000002829 204.0
HKD2_k127_1458596_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 3.043e-239 773.0
HKD2_k127_1458596_1 nucleic-acid-binding protein implicated in transcription termination K07742 - - 0.000000003675 61.0
HKD2_k127_1464250_0 Luciferase-like monooxygenase K15854 - 1.14.14.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 293.0
HKD2_k127_1464250_1 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000002142 122.0
HKD2_k127_1464250_2 COG3806 Anti-sigma factor - - - 0.000000000001216 76.0
HKD2_k127_1472672_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 415.0
HKD2_k127_1472672_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 321.0
HKD2_k127_1472672_2 Antitoxin Phd_YefM, type II toxin-antitoxin system - - - 0.00000007383 58.0
HKD2_k127_1472672_3 PIN domain - - - 0.0004929 49.0
HKD2_k127_1485816_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 323.0
HKD2_k127_1485816_1 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.0000000000000000000000000000000000000000000000000000001564 199.0
HKD2_k127_1485816_2 PFAM peptidase M24 - - - 0.000000000000000000000000000004381 121.0
HKD2_k127_1491996_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.0000000000000000001782 89.0
HKD2_k127_1491996_1 transcriptional regulator, XRE family K07726 - - 0.00000000000000009756 88.0
HKD2_k127_1491996_2 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000002923 78.0
HKD2_k127_1491996_3 Belongs to the UPF0312 family - - - 0.00000009107 60.0
HKD2_k127_1491996_4 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000001919 51.0
HKD2_k127_1493625_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 438.0
HKD2_k127_1496510_0 Belongs to the UPF0276 family K09930 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 361.0
HKD2_k127_1496510_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000002846 106.0
HKD2_k127_1496510_2 Putative DNA-binding domain - - - 0.0000000000000000000000003169 116.0
HKD2_k127_1496510_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000003634 97.0
HKD2_k127_1496510_4 - - - - 0.00000000000000002702 84.0
HKD2_k127_1500361_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004169 401.0
HKD2_k127_1515419_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002734 322.0
HKD2_k127_1515419_1 COG0657 Esterase lipase - - - 0.000000000006926 68.0
HKD2_k127_1534964_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 388.0
HKD2_k127_1534964_1 Belongs to the ribose-phosphate pyrophosphokinase family K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000001744 245.0
HKD2_k127_1534964_2 RNA-metabolising metallo-beta-lactamase K07576 - - 0.000000000000000000000000000000000000000000000045 175.0
HKD2_k127_1571546_0 Methionine synthase K00548 - 2.1.1.13 8.759e-203 640.0
HKD2_k127_1571765_0 Glutathione S-transferase K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 446.0
HKD2_k127_1571765_1 F420-dependent oxidoreductase, Rv2161c - - - 0.000000000000000000000000000000003378 136.0
HKD2_k127_1591652_0 Glutamine amidotransferases class-II K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009021 312.0
HKD2_k127_1591652_1 MutS domain I K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000000000000000000000000000000000000000006777 197.0
HKD2_k127_1613149_0 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 320.0
HKD2_k127_1613149_1 Polysaccharide biosynthesis protein K17716 - 5.1.3.2 0.000000000000000000000000000000008341 130.0
HKD2_k127_1617739_0 PFAM von Willebrand factor type A K07114 - - 0.000000000000000000000000000000000000001052 164.0
HKD2_k127_1617739_1 Forkhead associated domain - - - 0.0000000000002041 78.0
HKD2_k127_1617739_2 Transcriptional regulatory protein, C terminal - - - 0.00000000167 69.0
HKD2_k127_1617739_3 Multi-sensor signal transduction histidine kinase - - - 0.00000001669 66.0
HKD2_k127_1624908_0 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000002316 242.0
HKD2_k127_1625883_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00219 - 1.3.1.34 0.0000000000000000000000000000000000000000000000000000000006269 211.0
HKD2_k127_1625883_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000001784 151.0
HKD2_k127_1628910_0 Dihydrodipicolinate synthetase family K21062 - 3.5.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 398.0
HKD2_k127_1628910_1 pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000004371 81.0
HKD2_k127_1633052_0 Fe-S oxidoreductase K11473 - - 0.00000000000000000000000000000000000000000000000001077 194.0
HKD2_k127_1633052_1 FAD binding domain K11472 - - 0.000000009335 58.0
HKD2_k127_1652491_0 DNA polymerase K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000022 175.0
HKD2_k127_1657543_0 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 306.0
HKD2_k127_1657543_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000009868 117.0
HKD2_k127_1661811_0 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 424.0
HKD2_k127_1661811_1 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000008223 244.0
HKD2_k127_166464_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002193 314.0
HKD2_k127_166464_1 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000189 217.0
HKD2_k127_1682107_0 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001726 279.0
HKD2_k127_1682107_1 TPM domain - - - 0.000000000000000000000000000000000000000000000000000003501 198.0
HKD2_k127_1682107_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000007205 181.0
HKD2_k127_1696855_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 587.0
HKD2_k127_1699601_0 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000001685 229.0
HKD2_k127_1717454_0 ABC1 family - - - 0.000000000000000000000000000000000000000000000000000000000002061 222.0
HKD2_k127_1717454_1 Major facilitator Superfamily - - - 0.000000000000000003661 92.0
HKD2_k127_1741772_1 - - - - 0.0000000000000000001495 93.0
HKD2_k127_1750647_0 - - - - 0.00000000000000000000000000000000000000007051 158.0
HKD2_k127_1750647_1 Protein of unknown function (DUF1460) - - - 0.0000000000000000000008028 104.0
HKD2_k127_1750647_2 histone H2A K63-linked ubiquitination - - - 0.000000001216 68.0
HKD2_k127_1761971_0 Fimbrial assembly family protein K02461 - - 0.000004126 54.0
HKD2_k127_1761971_1 Type II secretion system (T2SS), protein M K02462 - - 0.0001645 52.0
HKD2_k127_1762117_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 513.0
HKD2_k127_1762117_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000006505 232.0
HKD2_k127_1762117_2 lytic transglycosylase activity - - - 0.00000000000000000000000000000000000000000001282 176.0
HKD2_k127_1762117_3 bacterial (prokaryotic) histone like domain K03530 - - 0.00000000000000000000003254 103.0
HKD2_k127_1775828_0 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000261 191.0
HKD2_k127_1775828_1 phosphohistidine phosphatase, SixA K08296 - - 0.00000000000000002817 86.0
HKD2_k127_1777599_0 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000000000000000000000000000000007642 145.0
HKD2_k127_1777599_1 PFAM glycosyl transferase family 39 K07264 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016763,GO:0033692,GO:0034637,GO:0034645,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.2.43 0.000000001545 70.0
HKD2_k127_1777599_2 regulatory protein, FmdB family - - - 0.000006308 52.0
HKD2_k127_1799509_0 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002708 343.0
HKD2_k127_1799509_1 SnoaL-like domain - - - 0.000000000000000000000000000000002715 135.0
HKD2_k127_1799509_2 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.0000000000005997 70.0
HKD2_k127_1805212_0 FAD dependent oxidoreductase K03153 - 1.4.3.19 0.0000000000000000000000000000000000000000000000000000000000000000001875 246.0
HKD2_k127_1805212_1 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000000000000005135 161.0
HKD2_k127_1810494_0 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000441 276.0
HKD2_k127_1810494_1 Lytic transglycosylase catalytic K08307 - - 0.000000000000000000000000000000004211 141.0
HKD2_k127_1812965_0 MMPL family - - - 0.00000001162 60.0
HKD2_k127_1812965_1 - - - - 0.00002085 55.0
HKD2_k127_1822571_0 aminopeptidase activity - - - 0.000000000000000000000000000000000002812 141.0
HKD2_k127_1822571_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000002126 54.0
HKD2_k127_1835438_0 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.0000000000000000000000001083 116.0
HKD2_k127_1835438_1 arylsulfatase activity K01138 - - 0.0009153 44.0
HKD2_k127_1836364_0 Elongation factor Tu domain 2 K02355 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 587.0
HKD2_k127_1836364_1 Protein of unknown function (DUF2905) - - - 0.000000000000000000889 87.0
HKD2_k127_1836742_0 PFAM Acetamidase Formamidase K01455 - 3.5.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 395.0
HKD2_k127_1836742_1 Contains 3'-5'exonuclease domain K02342 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000004777 273.0
HKD2_k127_1836742_2 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000008277 218.0
HKD2_k127_1836742_3 SMART Signal transduction response regulator, receiver region - - - 0.00000000000000000000000000000000000000000000000000000001544 205.0
HKD2_k127_1836742_4 Pfam:DUF59 - - - 0.000000000000000000000000000000000000000000000000000003617 195.0
HKD2_k127_1836742_5 MaoC like domain - - - 0.0000000000000000000000000000000000000000000003396 171.0
HKD2_k127_1836742_6 MlaA lipoprotein K04754 - - 0.000000000000000000000000000000000000000211 154.0
HKD2_k127_1836742_7 COG4308 Limonene-1,2-epoxide hydrolase K10533 - 3.3.2.8 0.00000000000000000000000002247 113.0
HKD2_k127_1836742_8 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000006681 57.0
HKD2_k127_1838624_0 lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000001062 194.0
HKD2_k127_1839485_0 Phosphate transport system permease K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004788 313.0
HKD2_k127_1839485_1 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 308.0
HKD2_k127_1839485_2 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000003114 229.0
HKD2_k127_1839485_3 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 0.00000000000000000000000007647 109.0
HKD2_k127_1857064_0 Male sterility protein K12454 - 5.1.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001663 274.0
HKD2_k127_1857064_1 ADP-glyceromanno-heptose 6-epimerase activity K01784,K12454 - 5.1.3.10,5.1.3.2 0.000000000000000000000000000000000000000000005626 166.0
HKD2_k127_1865134_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 292.0
HKD2_k127_1865134_1 With S4 and S5 plays an important role in translational accuracy K02950 - - 0.0000000000000000000000000000000000000000000000000000000003296 203.0
HKD2_k127_1865134_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - 0.0000000000000000001616 89.0
HKD2_k127_1875350_0 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000000001261 222.0
HKD2_k127_1875350_1 Smr domain - - - 0.000000000000000000000000000000000000000000007227 172.0
HKD2_k127_1875350_2 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000006383 68.0
HKD2_k127_1885271_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 3.506e-310 963.0
HKD2_k127_1888538_0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 420.0
HKD2_k127_1888538_1 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000000000000001573 135.0
HKD2_k127_1888538_2 Rhodanese Homology Domain - - - 0.000000008745 57.0
HKD2_k127_1892697_0 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 391.0
HKD2_k127_1892697_1 AAA ATPase domain - - - 0.0000000001157 63.0
HKD2_k127_1896622_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.0000000000000000000000000000000000000000000000000000000000000000000002308 241.0
HKD2_k127_1896622_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000003726 154.0
HKD2_k127_1896622_2 Methyltransferase domain - - - 0.000000000000000001708 94.0
HKD2_k127_1906985_0 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009954 494.0
HKD2_k127_1906985_1 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K15546 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003909 262.0
HKD2_k127_1906985_2 AMP-binding enzyme C-terminal domain K04105 - 6.2.1.25,6.2.1.27 0.0003116 44.0
HKD2_k127_1928818_0 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000005422 213.0
HKD2_k127_1928818_1 peptidase Do - - - 0.000000000003194 73.0
HKD2_k127_1972352_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005568 297.0
HKD2_k127_1972352_1 metallopeptidase activity - - - 0.0001077 50.0
HKD2_k127_1973746_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009485 402.0
HKD2_k127_1973746_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000002443 189.0
HKD2_k127_1973746_2 amidohydrolase - - - 0.00000000000000000000000000000284 124.0
HKD2_k127_1973746_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000009093 119.0
HKD2_k127_1973746_4 ParE toxin of type II toxin-antitoxin system, parDE K06218 - - 0.000000000000000000003918 94.0
HKD2_k127_1989432_0 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000000000006806 194.0
HKD2_k127_1989432_1 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.0005692 43.0
HKD2_k127_2007297_0 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 482.0
HKD2_k127_2007297_1 pyruvate flavodoxin ferredoxin oxidoreductase K00169,K03737 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 351.0
HKD2_k127_2007297_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.000132 48.0
HKD2_k127_2007998_0 Acyl-CoA dehydrogenase, N-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006851 432.0
HKD2_k127_2007998_1 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000006263 89.0
HKD2_k127_2007998_2 KR domain K07124 - - 0.0001211 45.0
HKD2_k127_2034863_0 B12 binding domain K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000003968 231.0
HKD2_k127_2034863_1 Neurotransmitter-gated ion-channel ligand binding domain - - - 0.0000000000000000000000000000008095 129.0
HKD2_k127_2036884_0 Dehydrogenase K15371 - 1.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000006151 266.0
HKD2_k127_2037757_0 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000292 273.0
HKD2_k127_2037757_1 COG1145 Ferredoxin - - - 0.0000000000000000000000000005764 123.0
HKD2_k127_2037757_2 cheY-homologous receiver domain K03413 - - 0.000000000612 63.0
HKD2_k127_2037757_3 Histidine Phosphotransfer domain - - - 0.00005243 51.0
HKD2_k127_2044888_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008502 352.0
HKD2_k127_2044888_1 hydrogenase expression formation protein HypE K04655 - - 0.000000000000000000000000000000000000000000008111 166.0
HKD2_k127_2045479_0 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000001773 192.0
HKD2_k127_2045479_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000002698 181.0
HKD2_k127_2045479_2 EVE domain - - - 0.0000000000000000000000000000000000006565 141.0
HKD2_k127_2055258_0 F420-dependent oxidoreductase, Rv2161c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003834 276.0
HKD2_k127_2055258_1 Protein of unknown function (DUF1722) - - - 0.0000000000000000002184 88.0
HKD2_k127_2055258_2 F420-dependent oxidoreductase, Rv2161c - - - 0.00001183 49.0
HKD2_k127_2059098_0 Belongs to the peptidase S16 family K01338,K04076,K04770 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 487.0
HKD2_k127_2059098_1 Elongator protein 3, MiaB family, Radical SAM K04034 - 1.21.98.3 0.000000000000000000000000000000000000000000003706 166.0
HKD2_k127_2075892_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000002384 93.0
HKD2_k127_2075892_1 VanZ like family - - - 0.0000000000000003893 84.0
HKD2_k127_2077655_0 NAD(P) transhydrogenase beta subunit K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006258 563.0
HKD2_k127_2088489_0 pfam abc K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 328.0
HKD2_k127_2088489_1 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000001237 217.0
HKD2_k127_2095720_0 Belongs to the DapB family K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000004575 210.0
HKD2_k127_2095720_1 Hep Hag repeat protein K21449 - - 0.000000000006934 72.0
HKD2_k127_2106651_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000958 306.0
HKD2_k127_2117142_0 Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003099 319.0
HKD2_k127_2126747_0 RNA ligase activity K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 571.0
HKD2_k127_2126747_1 Luciferase-like monooxygenase K00320 - 1.5.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006643 309.0
HKD2_k127_2126747_2 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003281 252.0
HKD2_k127_2126747_3 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000001992 199.0
HKD2_k127_2126747_4 redox protein regulator of disulfide bond formation - - - 0.0000000000000000000000000000000000006271 143.0
HKD2_k127_2126747_5 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000001237 80.0
HKD2_k127_2126747_6 Archease protein family (MTH1598/TM1083) - - - 0.000000000000001399 86.0
HKD2_k127_2126902_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 1.178e-204 652.0
HKD2_k127_2126902_1 Luciferase-like monooxygenase - - - 0.00000000003577 64.0
HKD2_k127_2132474_0 Transporter associated domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000706 268.0
HKD2_k127_2132474_1 flavin adenine dinucleotide binding - - - 0.000000000000000000000000000000000000000000483 165.0
HKD2_k127_2132474_2 PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase K06898 - - 0.000000000000000000503 89.0
HKD2_k127_2133285_0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family - - - 0.000000000000000000000000000000000000000000000000000000000000004329 227.0
HKD2_k127_2133285_1 Protein of unknown function (DUF1573) - - - 0.0000000000002041 80.0
HKD2_k127_2149699_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 336.0
HKD2_k127_2153938_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004598 537.0
HKD2_k127_2153938_1 CYTH K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000006949 225.0
HKD2_k127_2153938_2 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.0000000000000000000000000000000000000000000000000000000001787 216.0
HKD2_k127_2153938_3 ketol-acid reductoisomerase activity K00053 - 1.1.1.86 0.000000000000000000000000000000000000000004889 158.0
HKD2_k127_2153938_4 - - - - 0.00000000000000005899 89.0
HKD2_k127_2153938_5 Rhodanese Homology Domain - - - 0.00000000005894 65.0
HKD2_k127_2153938_6 low-complexity proteins - - - 0.000000002064 67.0
HKD2_k127_2174616_0 Phage integrase family - - - 0.0000000000000000000000000000000000000000000000007039 184.0
HKD2_k127_2174616_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K07062 - - 0.00000000000000000000000000000000000000000000001535 173.0
HKD2_k127_2174616_2 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000149 76.0
HKD2_k127_2181849_0 imidazolonepropionase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 495.0
HKD2_k127_2181849_1 Histidine kinase - - - 0.0000000004695 60.0
HKD2_k127_2184314_0 SMART PDZ DHR GLGF domain protein K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001078 267.0
HKD2_k127_2184314_1 PFAM Peptidase M22, glycoprotease K14742 - - 0.000000000000000000000000000006718 126.0
HKD2_k127_2184314_2 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000003942 101.0
HKD2_k127_219073_0 PFAM luciferase family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 309.0
HKD2_k127_219073_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000006227 160.0
HKD2_k127_219073_2 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00363,K05710 - 1.7.1.15 0.0000000000000000002793 90.0
HKD2_k127_219073_3 cellular response to dsDNA K11211 - 2.7.1.166 0.0002682 51.0
HKD2_k127_2309308_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.000000000000000000000000000000000000004517 153.0
HKD2_k127_2309308_1 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000000000000000000004491 111.0
HKD2_k127_2309308_2 Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position K11211 - 2.7.1.166 0.0003759 47.0
HKD2_k127_2326682_0 PFAM aldo keto reductase K05882 - 1.1.1.91 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 389.0
HKD2_k127_2328391_0 Flavin-binding monooxygenase-like - - - 1.909e-237 748.0
HKD2_k127_2328391_1 Aldo/keto reductase family - - - 0.000000000000000000000000000323 117.0
HKD2_k127_2328715_0 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000116 292.0
HKD2_k127_2328715_1 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000003656 184.0
HKD2_k127_2328923_0 PFAM isocitrate isopropylmalate dehydrogenase K00030,K07246 - 1.1.1.41,1.1.1.83,1.1.1.93,4.1.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008619 379.0
HKD2_k127_2328923_1 Oxidoreductase molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001874 254.0
HKD2_k127_2328923_2 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000001494 197.0
HKD2_k127_2333701_0 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000003067 170.0
HKD2_k127_2333701_1 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000008126 81.0
HKD2_k127_2333701_2 Protein of unknown function (DUF1329) - - - 0.00006856 55.0
HKD2_k127_2359609_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000524 437.0
HKD2_k127_2360213_0 Peptidase family M1 domain K08776 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 438.0
HKD2_k127_2363484_0 Pfam:DUF162 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000043 248.0
HKD2_k127_2363484_1 LUD domain - - - 0.00000000000000003021 92.0
HKD2_k127_2363484_2 Fe-S oxidoreductase K18928 - - 0.00003726 47.0
HKD2_k127_2365492_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 507.0
HKD2_k127_2366299_0 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000004193 108.0
HKD2_k127_2389513_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 524.0
HKD2_k127_2389513_1 PFAM PhoH family protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 408.0
HKD2_k127_2389513_2 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 353.0
HKD2_k127_2389513_3 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000004439 121.0
HKD2_k127_2389513_4 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000008979 93.0
HKD2_k127_2389513_5 - - - - 0.0000000000000000002798 96.0
HKD2_k127_2390458_0 Conserved hypothetical protein 95 - - - 0.0000000000000000000000003556 107.0
HKD2_k127_2390458_1 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000001755 93.0
HKD2_k127_2406623_0 Bacterial DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002874 411.0
HKD2_k127_2406623_1 McrBC 5-methylcytosine restriction system component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 310.0
HKD2_k127_2414367_0 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003885 293.0
HKD2_k127_2422004_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000001789 263.0
HKD2_k127_2422004_1 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000002876 167.0
HKD2_k127_2423091_0 unusual protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000001406 229.0
HKD2_k127_2423091_1 PFAM 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase K06898 - - 0.000000000000000000000000000000000000000000000000000001876 195.0
HKD2_k127_2423091_2 Aldo/keto reductase family - - - 0.0000000000000000000000000001107 116.0
HKD2_k127_2423140_0 RND efflux system, outer membrane lipoprotein K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008938 409.0
HKD2_k127_2423140_1 PFAM Polyphosphate kinase 2 K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006851 388.0
HKD2_k127_2423140_2 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000000001329 193.0
HKD2_k127_2423140_3 Tetratricopeptide TPR_2 repeat protein - - - 0.00002268 54.0
HKD2_k127_2472470_0 CoA-transferase family III K14470 - 5.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000536 493.0
HKD2_k127_2472470_1 PFAM Hydantoinase oxoprolinase K01469,K01473 - 3.5.2.14,3.5.2.9 0.0000000001746 64.0
HKD2_k127_2497735_0 Catalyzes the conversion of dihydroorotate to orotate K00226,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.98.1 0.00000000000000000006084 100.0
HKD2_k127_2497735_1 proteolysis K21140,K21147 - 2.7.7.80,2.8.1.11,3.13.1.6 0.000000000000000008455 94.0
HKD2_k127_2539586_0 ABC-2 family transporter protein K13926 - - 2.211e-287 895.0
HKD2_k127_2539586_1 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000001723 134.0
HKD2_k127_2543774_0 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 531.0
HKD2_k127_2543774_1 Flavin-binding monooxygenase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 314.0
HKD2_k127_2543774_2 Acyl-CoA dehydrogenase, N-terminal domain K00248 - 1.3.8.1 0.00000000000000000000007435 108.0
HKD2_k127_2561646_0 PFAM glucose-methanol-choline oxidoreductase K03333 - 1.1.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003821 517.0
HKD2_k127_2561646_1 SCO1 SenC K07152 - - 0.00000000000002209 80.0
HKD2_k127_2568895_0 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 413.0
HKD2_k127_2571109_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 364.0
HKD2_k127_2574093_0 MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000000000000000000000000006758 220.0
HKD2_k127_2574093_1 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000000008989 91.0
HKD2_k127_2575592_0 PFAM Binding-protein-dependent transport K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 331.0
HKD2_k127_2575592_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000005519 178.0
HKD2_k127_2575592_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000005935 152.0
HKD2_k127_2591625_0 PFAM CobQ CobB MinD ParA nucleotide binding domain - - - 0.00000000000000000000000000000000000000000001401 171.0
HKD2_k127_2591625_1 PFAM O-Antigen K18814 - - 0.000737 48.0
HKD2_k127_2616339_0 flavoprotein involved in K transport - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 571.0
HKD2_k127_2616339_1 Nad-dependent epimerase dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 374.0
HKD2_k127_2616339_2 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 320.0
HKD2_k127_2616339_3 stress-induced mitochondrial fusion - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001557 262.0
HKD2_k127_2616339_4 Ring hydroxylating alpha subunit (catalytic domain) K00499 - 1.14.15.7 0.0000000000000000000000000000000000000000000000000000000000000006811 229.0
HKD2_k127_2616339_5 Bacterial regulatory proteins, tetR family - - - 0.0000000003762 70.0
HKD2_k127_2624409_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 287.0
HKD2_k127_2624409_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000002444 185.0
HKD2_k127_2624409_2 AI-2E family transporter - - - 0.00000000000000000000000000000001988 139.0
HKD2_k127_2627953_0 PFAM glucosamine galactosamine-6-phosphate isomerase K01057 - 3.1.1.31 0.000000000000000000000000000000000000000000000000000000000000005115 226.0
HKD2_k127_2627953_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000005093 219.0
HKD2_k127_2637738_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006236 560.0
HKD2_k127_2640287_0 SLBB domain K01991 - - 0.0000000000000000000000000000000000000003928 155.0
HKD2_k127_2640287_1 Hint domain - - - 0.000000000000000000000000000000000000005834 155.0
HKD2_k127_2648830_0 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000003504 263.0
HKD2_k127_2648830_1 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000001861 202.0
HKD2_k127_2648830_2 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.0000000000000000000000002397 106.0
HKD2_k127_2648830_3 Belongs to the CDS family K00981 - 2.7.7.41 0.000000000764 66.0
HKD2_k127_2652748_0 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004179 269.0
HKD2_k127_2652748_1 PGAP1-like protein - - - 0.0000000008037 64.0
HKD2_k127_2666926_0 Putative cyclase - - - 0.00000000000000000000000000001203 123.0
HKD2_k127_2666926_1 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.000000000000000008566 88.0
HKD2_k127_2684905_0 Type IV pilus assembly protein PilM; K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001691 532.0
HKD2_k127_2684905_1 COG5009 Membrane carboxypeptidase penicillin-binding protein K05366 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000006119 216.0
HKD2_k127_2684905_2 Fimbrial assembly protein (PilN) K02663 - - 0.000000000000000000000001935 113.0
HKD2_k127_2714171_0 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 0.0000000000000000000000000000000000000000000000000001124 199.0
HKD2_k127_2714171_1 Belongs to the UPF0434 family K09791 - - 0.000000000000000001711 85.0
HKD2_k127_271915_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 3.924e-243 776.0
HKD2_k127_2723649_0 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 507.0
HKD2_k127_2747667_0 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 405.0
HKD2_k127_2747667_1 drug resistance transporter, EmrB QacA subfamily K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007762 370.0
HKD2_k127_2747667_2 Methionyl-tRNA formyltransferase K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002451 283.0
HKD2_k127_2747667_3 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000001606 113.0
HKD2_k127_2747667_4 Major Facilitator Superfamily - - - 0.0000000000000003498 84.0
HKD2_k127_2768364_0 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002072 402.0
HKD2_k127_2768364_1 ABC-type transport auxiliary lipoprotein component K09857 - - 0.00009303 49.0
HKD2_k127_2782203_0 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 332.0
HKD2_k127_2782203_1 Enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000007837 199.0
HKD2_k127_2782910_0 Biotin carboxylase C-terminal domain - - - 0.0 1043.0
HKD2_k127_2836629_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005911 426.0
HKD2_k127_2836629_1 Dihydrodipicolinate synthetase family - - - 0.00000000000000002085 83.0
HKD2_k127_2841864_0 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 338.0
HKD2_k127_2841864_1 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000219 244.0
HKD2_k127_2841864_2 Universal stress protein family - - - 0.0000000000000000000000000000008088 127.0
HKD2_k127_2848147_0 TIGRFAM cell shape determining protein, MreB Mrl family K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003664 533.0
HKD2_k127_2848147_1 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000001768 256.0
HKD2_k127_2848147_2 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000000000000000000228 195.0
HKD2_k127_2887955_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 1.484e-199 629.0
HKD2_k127_2887955_1 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000000000000064 115.0
HKD2_k127_2887955_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0000005834 52.0
HKD2_k127_2890534_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 489.0
HKD2_k127_2891027_0 Enoyl-(Acyl carrier protein) reductase K00208 - 1.3.1.10,1.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002734 282.0
HKD2_k127_2891027_1 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000006146 242.0
HKD2_k127_2891027_2 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000003205 180.0
HKD2_k127_2891027_3 Luciferase-like monooxygenase K04091 - 1.14.14.5 0.000003141 53.0
HKD2_k127_2914388_0 TIGRFAM competence damage-inducible protein CinA K03742,K03743 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004461 297.0
HKD2_k127_2924156_0 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000835 219.0
HKD2_k127_2924156_1 Belongs to the universal ribosomal protein uS2 family K02967 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000004462 90.0
HKD2_k127_2928732_0 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000004593 243.0
HKD2_k127_2928732_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000004877 169.0
HKD2_k127_2928732_2 Acyl-CoA dehydrogenase, N-terminal domain K00249 - 1.3.8.7 0.0000000000000000157 85.0
HKD2_k127_2930291_0 Beta-lactamase superfamily domain K13075 - 3.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000003198 228.0
HKD2_k127_2947088_0 MMPL family K07003 - - 0.00000000000000000000000000000000000000002688 168.0
HKD2_k127_2948991_0 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005922 309.0
HKD2_k127_2948991_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000994 237.0
HKD2_k127_2948991_2 - - - - 0.00002161 46.0
HKD2_k127_2953474_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 520.0
HKD2_k127_2953474_1 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.00000000000000000000000000000000001629 141.0
HKD2_k127_2963674_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000006776 205.0
HKD2_k127_2963674_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.00001442 49.0
HKD2_k127_2982192_0 Binding-protein-dependent transport system inner membrane component K02033,K15585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009462 372.0
HKD2_k127_2982192_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000345 175.0
HKD2_k127_2997065_0 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000004429 240.0
HKD2_k127_2997065_1 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000006122 201.0
HKD2_k127_30117_0 Selenoprotein B glycine betaine sarcosine D-proline reductase K10794 - 1.21.4.1 0.00000000000000000000000000000000000000000003842 165.0
HKD2_k127_30117_1 Glutathione S-transferase, C-terminal domain K00799,K03599 - 2.5.1.18 0.0000000000000000000000002825 115.0
HKD2_k127_30117_2 - - - - 0.0000000000000000000000005491 108.0
HKD2_k127_30117_3 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000004325 98.0
HKD2_k127_3021065_0 Glycosyltransferase Family 4 K02844 - - 0.0000000000000000000000000000000000000000000000000001873 199.0
HKD2_k127_3021065_1 Glycosyltransferase like family 2 - - - 0.0000000009756 65.0
HKD2_k127_3021065_2 - K13924,K15580 - 2.1.1.80,3.1.1.61 0.00001183 49.0
HKD2_k127_3046685_0 Flavoprotein involved in K transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004113 255.0
HKD2_k127_3046685_1 amidohydrolase K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000009377 175.0
HKD2_k127_3080987_0 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 457.0
HKD2_k127_3080987_1 Hydrolase of X-linked nucleoside diphosphate N terminal - - - 0.000000000000000000000000000000000000000001056 164.0
HKD2_k127_3096273_0 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003701 282.0
HKD2_k127_3096273_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000006798 72.0
HKD2_k127_3097598_0 Outer membrane efflux protein K18300,K19593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 590.0
HKD2_k127_3097598_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 314.0
HKD2_k127_3101476_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 469.0
HKD2_k127_3101476_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000001428 136.0
HKD2_k127_311000_0 PFAM Prenyltransferase squalene oxidase K01852,K06045 - 4.2.1.129,5.4.99.17,5.4.99.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003261 398.0
HKD2_k127_311000_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000973 268.0
HKD2_k127_3133707_0 Chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 353.0
HKD2_k127_3133707_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 332.0
HKD2_k127_3150598_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000216 164.0
HKD2_k127_3161275_0 deoxyhypusine monooxygenase activity - - - 0.00008962 55.0
HKD2_k127_3171043_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 329.0
HKD2_k127_3171043_1 argininosuccinate lyase K01755,K14681 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.000000000000000000000000000000000000000000000000000000000004482 214.0
HKD2_k127_3178230_0 PFAM Pyruvate carboxyltransferase K01640,K18314 - 4.1.3.4,4.1.3.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008469 284.0
HKD2_k127_3178230_1 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000002536 271.0
HKD2_k127_3178230_2 Protein of unknown function (DUF1003) - - - 0.0000000000000000000000000000000000000000006526 163.0
HKD2_k127_3178555_0 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 318.0
HKD2_k127_3196406_0 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003266 285.0
HKD2_k127_3214293_0 elongation factor Tu domain 2 protein K06207 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 323.0
HKD2_k127_3214293_1 methylamine metabolic process - - - 0.00000000000000008374 84.0
HKD2_k127_3215756_0 Transport and Golgi organisation 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000001165 235.0
HKD2_k127_3215756_1 Transport and Golgi organisation 2 K01755 - 4.3.2.1 0.000000000000000000000005385 104.0
HKD2_k127_3225324_0 Protein conserved in bacteria K20444 - - 0.00000000000000000000000000000000000000001916 163.0
HKD2_k127_3225324_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000005248 126.0
HKD2_k127_3229730_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 450.0
HKD2_k127_3229730_1 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000003321 132.0
HKD2_k127_3260872_0 Haem-degrading - - - 0.0000000000000000000002441 101.0
HKD2_k127_3260872_1 von Willebrand factor (vWF) type A domain - - - 0.0000000003152 72.0
HKD2_k127_3260872_2 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.0001275 48.0
HKD2_k127_3305170_0 PFAM Dopa 4,5-dioxygenase family K10253 - - 0.0000000000000000000000000000000000000003398 153.0
HKD2_k127_3305170_1 acetyltransferase - - - 0.0000000000000000000000000000000000006098 146.0
HKD2_k127_3305170_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000546 141.0
HKD2_k127_3310479_0 dipeptidyl-peptidase activity K06978 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 483.0
HKD2_k127_3322697_0 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009036 439.0
HKD2_k127_3322697_1 PFAM ABC transporter, transmembrane region K06147,K11085 - - 0.000000000000000000000000000000000000002671 152.0
HKD2_k127_3328785_0 Domain of unknown function (DUF4340) - - - 0.0000000000000000000000000000000001898 149.0
HKD2_k127_3328785_1 PFAM ABC-type uncharacterised transport system K01992 - - 0.0000000000000000000000000000000006108 142.0
HKD2_k127_3333298_0 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000001124 248.0
HKD2_k127_3333298_1 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000001361 159.0
HKD2_k127_3359749_0 Belongs to the 'phage' integrase family. XerC subfamily K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000002787 208.0
HKD2_k127_3359749_1 Proteasome subunit K01419 - 3.4.25.2 0.00000000000000000000001842 101.0
HKD2_k127_3359749_2 - - - - 0.000000000000000003073 94.0
HKD2_k127_3380374_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00928,K12524 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000004632 257.0
HKD2_k127_3380374_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000005449 175.0
HKD2_k127_3390327_0 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.0000000000000000000000000000000000000000000000000000000000000000000000003317 258.0
HKD2_k127_3391031_0 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000002301 175.0
HKD2_k127_3391031_1 DNA helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000001658 156.0
HKD2_k127_3397273_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710,K12450 - 4.2.1.46,4.2.1.76 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006007 482.0
HKD2_k127_3397273_1 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004077 276.0
HKD2_k127_3397273_2 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001055 275.0
HKD2_k127_3397273_3 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000001866 116.0
HKD2_k127_3412304_0 Carboxylesterase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001123 247.0
HKD2_k127_3412304_1 PFAM Glyoxalase bleomycin resistance protein dioxygenase K07104 - 1.13.11.2 0.000000000000000000000000000000000000000000000000000000426 196.0
HKD2_k127_3412304_2 Protein of unknown function (DUF2950) K02396 - - 0.0000000002863 62.0
HKD2_k127_3418923_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 370.0
HKD2_k127_3418923_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000002424 186.0
HKD2_k127_3418923_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000004889 158.0
HKD2_k127_3418923_3 Tetratricopeptide repeat - - - 0.00000837 55.0
HKD2_k127_344454_0 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 378.0
HKD2_k127_344454_1 Amidase K01426 - 3.5.1.4 0.0000000000000000000000000000002895 128.0
HKD2_k127_344454_3 Luciferase-like monooxygenase K14733 - 1.14.13.107 0.0006215 44.0
HKD2_k127_3462617_0 MMPL family K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005387 329.0
HKD2_k127_3462617_1 Belongs to the TPP enzyme family K01637 - 4.1.3.1 0.00000000000332 70.0
HKD2_k127_3475398_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 305.0
HKD2_k127_3475398_1 - - - - 0.000001383 55.0
HKD2_k127_3483886_0 AAA domain - - - 0.000000000000000000000000000000000000000000002291 175.0
HKD2_k127_3483886_1 RmuC family K09760 - - 0.0000000000000001723 84.0
HKD2_k127_3501238_0 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000007524 250.0
HKD2_k127_3501238_1 F420-dependent oxidoreductase, Rv2161c - - - 0.00000000000000000000000000000000000000000000000000000000005462 212.0
HKD2_k127_3501238_2 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000001925 92.0
HKD2_k127_3502205_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 433.0
HKD2_k127_3515054_0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.00000000000000001173 88.0
HKD2_k127_3515054_1 Alpha beta hydrolase - - - 0.000000000001807 68.0
HKD2_k127_3515054_2 Tetratricopeptide repeat - - - 0.0000192 55.0
HKD2_k127_3517555_0 response to heat K07090 - - 0.000000000000000000000000000000000000000000000000003342 185.0
HKD2_k127_3517555_1 HAD-hyrolase-like K16017 - - 0.0000000005478 69.0
HKD2_k127_3518095_0 DEAD/H associated K03724 - - 2.569e-238 764.0
HKD2_k127_3518095_1 Zn-dependent metallo-hydrolase RNA specificity domain K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000995 497.0
HKD2_k127_3532729_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01883,K12339 - 2.5.1.47,6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008461 354.0
HKD2_k127_3532729_1 TIGRFAM MoaD family protein K03636 - - 0.0000000000000000000000000000009888 123.0
HKD2_k127_3532729_2 NIL domain - - - 0.000000000000001892 86.0
HKD2_k127_3532729_3 Molybdopterin biosynthesis protein MoeB K21029 - 2.7.7.80 0.00000001901 64.0
HKD2_k127_3545851_0 transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003784 247.0
HKD2_k127_3545851_1 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000198 242.0
HKD2_k127_3545851_2 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000003797 175.0
HKD2_k127_3545851_3 - - - - 0.00000000000000000000000000000001721 129.0
HKD2_k127_3545851_4 SnoaL-like domain - - - 0.0000007424 56.0
HKD2_k127_3545851_5 PFAM Rhodanese domain protein - - - 0.00000948 50.0
HKD2_k127_3548747_0 peptidase M20 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006169 414.0
HKD2_k127_3550467_0 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 315.0
HKD2_k127_3553538_0 Bacterial protein of unknown function (DUF899) - - - 0.0000000000000000000000000000000000000000000000000000000000001774 215.0
HKD2_k127_3553538_1 hydroperoxide reductase activity - - - 0.00000000000000000000000000000000004305 139.0
HKD2_k127_3553538_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000159 116.0
HKD2_k127_3553538_3 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000001509 107.0
HKD2_k127_3567337_0 - - - - 0.0000000000000001208 90.0
HKD2_k127_3567337_1 cell adhesion involved in biofilm formation - - - 0.000000003205 60.0
HKD2_k127_3587202_0 PFAM beta-lactamase domain protein K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007554 434.0
HKD2_k127_3587202_1 PFAM DSBA oxidoreductase - - - 0.00000000000000000000000000000000000005684 151.0
HKD2_k127_3587202_2 of the double-stranded beta helix - - - 0.0000000000000000000000000000376 123.0
HKD2_k127_3587202_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000863 105.0
HKD2_k127_3587202_4 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.0002045 45.0
HKD2_k127_3595678_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K02887,K03628 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 7.414e-212 662.0
HKD2_k127_360156_0 Enoyl-CoA hydratase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 314.0
HKD2_k127_360156_1 SecD/SecF GG Motif K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005443 254.0
HKD2_k127_360206_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006784 392.0
HKD2_k127_360206_1 RNase H K03469 - 3.1.26.4 0.0000000000000000000000000000000000008131 144.0
HKD2_k127_360206_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000004665 116.0
HKD2_k127_362263_0 aldehyde oxidase and xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008104 406.0
HKD2_k127_362263_1 CO dehydrogenase flavoprotein C-terminal domain K11178 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007378 301.0
HKD2_k127_3640939_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 558.0
HKD2_k127_3671246_0 metal-dependent hydrolase with the TIM-barrel fold K07048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 332.0
HKD2_k127_3671246_1 PFAM ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000002463 242.0
HKD2_k127_3671246_2 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000001559 134.0
HKD2_k127_3671246_3 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.00000000000003973 78.0
HKD2_k127_3691144_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000891 578.0
HKD2_k127_3724881_0 protein histidine kinase activity K10439 - - 0.0000000000000000000000000000000000000000006594 174.0
HKD2_k127_3724881_1 Major facilitator superfamily K03446 - - 0.000000000000000000000001397 110.0
HKD2_k127_3725543_0 metal-dependent hydrolase of the TIM-barrel fold K07045 - - 0.000000000000000000000000000000000002188 151.0
HKD2_k127_3725543_1 Cyclic nucleotide-monophosphate binding domain K10914 - - 0.0000000009808 67.0
HKD2_k127_3728232_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000004456 271.0
HKD2_k127_3728232_1 ATPase associated with various cellular activities AAA_5 K04748 - - 0.00000000000000000000000000000000000000000000000000000000737 202.0
HKD2_k127_3735552_0 - - - - 0.00000000000000000000000000000000000000000002026 171.0
HKD2_k127_3735552_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000001447 85.0
HKD2_k127_3744352_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002295 403.0
HKD2_k127_3744352_1 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.000000000000000000000000000000000000000000002993 169.0
HKD2_k127_3744352_2 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000005648 79.0
HKD2_k127_3744352_3 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000286 63.0
HKD2_k127_3753792_0 Transglutaminase/protease-like homologues - - - 0.0 1275.0
HKD2_k127_3753792_1 Circularly permuted ATP-grasp type 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007892 503.0
HKD2_k127_3754224_0 PFAM ABC transporter related K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002865 337.0
HKD2_k127_3754224_1 hydrolase activity, acting on ester bonds - - - 0.000000000000000007826 89.0
HKD2_k127_3754224_2 Phosphotransferase enzyme family - - - 0.00000000000007055 76.0
HKD2_k127_3754744_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 9.415e-198 625.0
HKD2_k127_3754744_1 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000000000000001696 105.0
HKD2_k127_3756947_0 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 347.0
HKD2_k127_3756947_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000001903 206.0
HKD2_k127_3756947_2 - - - - 0.00000000000000000000002024 100.0
HKD2_k127_377563_0 zinc finger K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001315 345.0
HKD2_k127_3797231_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003953 433.0
HKD2_k127_3797231_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.00000000000000000000000000000000000000000003487 168.0
HKD2_k127_3797231_2 ADP binding - - - 0.00000005735 55.0
HKD2_k127_3826599_0 proline dipeptidase activity K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 317.0
HKD2_k127_3826599_1 Nitroreductase family - - - 0.0000000000000000000000000000000001202 138.0
HKD2_k127_3826599_2 Permease, YjgP YjgQ family K11720 - - 0.000000000000009219 80.0
HKD2_k127_3847892_0 Carboxylesterase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004118 482.0
HKD2_k127_3847892_1 phosphoribosyltransferase K07100 - - 0.00000000000000000000000000000000000000000000007438 172.0
HKD2_k127_3850364_0 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00162,K21417 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 402.0
HKD2_k127_3850364_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K21416 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000001835 220.0
HKD2_k127_3875395_0 PFAM Polysaccharide biosynthesis export protein K01991 - - 0.000000000000008603 80.0
HKD2_k127_3875395_1 CobQ CobB MinD ParA nucleotide binding domain - - - 0.00000000007764 73.0
HKD2_k127_390403_0 Polysaccharide biosynthesis protein K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006166 439.0
HKD2_k127_3910331_0 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.0000000000000000000000000000000000000004028 157.0
HKD2_k127_3910331_1 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides K08281 - 3.5.1.19 0.000000000000000000000000001429 123.0
HKD2_k127_3910331_2 COG1230 Co Zn Cd efflux system component K16264 - - 0.00000000000000006994 83.0
HKD2_k127_3910331_3 Protein of unknown function (DUF983) - - - 0.0002695 50.0
HKD2_k127_3911730_0 UvrD REP helicase K16898 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000394 277.0
HKD2_k127_3911730_1 exonuclease activity K16899 - 3.6.4.12 0.000000000004875 78.0
HKD2_k127_3933505_0 dehydratase - - - 0.00000000000000000000000000000000000004428 145.0
HKD2_k127_3933505_1 Receptor family ligand binding region K01999 - - 0.00000000000000000004451 101.0
HKD2_k127_39378_0 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 409.0
HKD2_k127_39378_1 Dodecin K09165 - - 0.00000000000000000001124 94.0
HKD2_k127_3944558_0 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003017 315.0
HKD2_k127_3944558_1 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009009 297.0
HKD2_k127_3944558_2 Binding-protein-dependent transport system inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001925 265.0
HKD2_k127_3944558_3 Limonene-1,2-epoxide hydrolase catalytic domain K10533 - 3.3.2.8 0.00000000000000000000000000001002 123.0
HKD2_k127_3944558_4 anion transmembrane transporter activity K02049 - - 0.00000000000000000000000000776 116.0
HKD2_k127_3956540_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 287.0
HKD2_k127_3956540_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001091 258.0
HKD2_k127_3956540_2 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000001382 197.0
HKD2_k127_3971496_0 Flavoprotein involved in K transport K03379,K21730 - 1.14.13.160,1.14.13.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 581.0
HKD2_k127_4010326_0 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 288.0
HKD2_k127_4010326_1 - - - - 0.00000000000000000000000000000000000000000000000205 183.0
HKD2_k127_4013839_0 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 503.0
HKD2_k127_4013839_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 355.0
HKD2_k127_4013839_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006891 302.0
HKD2_k127_4013839_3 Phosphoesterase family K01114 - 3.1.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003366 291.0
HKD2_k127_4013839_4 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000105 200.0
HKD2_k127_4015497_0 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004701 309.0
HKD2_k127_404061_0 VWA domain containing CoxE-like protein K07161 - - 0.000000000000000000000000000000007562 140.0
HKD2_k127_404061_1 Acetyl-CoA hydrolase/transferase C-terminal domain K01067 - 3.1.2.1 0.00000000000000000000000000001962 119.0
HKD2_k127_404061_2 protein conserved in bacteria - - - 0.000001784 58.0
HKD2_k127_4052163_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000009072 224.0
HKD2_k127_4052163_1 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000004804 94.0
HKD2_k127_4052163_2 ArsC family - - - 0.0000000000000002346 82.0
HKD2_k127_4073314_0 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000004466 144.0
HKD2_k127_4079835_0 DNA polymerase type-B family K02336 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004344 353.0
HKD2_k127_4079835_1 Methyltransferase small domain - - - 0.000000000000000000000000003695 119.0
HKD2_k127_4089914_0 epoxide hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 502.0
HKD2_k127_4089914_1 PFAM Enoyl-CoA hydratase isomerase K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 300.0
HKD2_k127_4089914_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001632 267.0
HKD2_k127_4089914_3 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000002327 183.0
HKD2_k127_4089914_4 Bacterial regulatory proteins, tetR family - - - 0.000005509 50.0
HKD2_k127_4100995_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 342.0
HKD2_k127_4100995_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 310.0
HKD2_k127_4100995_2 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.00000000264 66.0
HKD2_k127_4120386_0 UbiA prenyltransferase family K02548 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 0.0000000000000000000000000000000000000000000000000002022 196.0
HKD2_k127_412973_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000001773 220.0
HKD2_k127_4142280_0 Male sterility protein K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005446 464.0
HKD2_k127_4143490_0 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.00000000000000000000000000000000000000000000000000000000000002453 224.0
HKD2_k127_4143490_1 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 0.000000000000000000000002723 114.0
HKD2_k127_4155274_0 oxidase, subunit K00425 - 1.10.3.14 0.000000000000000000002393 95.0
HKD2_k127_4165979_0 AAA domain (Cdc48 subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006568 393.0
HKD2_k127_4165979_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.00000000000000000000000000000000000003386 147.0
HKD2_k127_4165979_2 - - - - 0.000000005111 62.0
HKD2_k127_4167684_0 histidine kinase, HAMP K13598 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 319.0
HKD2_k127_4179368_0 lactate metabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001291 553.0
HKD2_k127_4179368_1 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000001957 209.0
HKD2_k127_4193034_0 ferredoxin-NADP+ reductase activity K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.00000000000000000000000000000000000000000004644 162.0
HKD2_k127_4193034_1 Auxiliary transport protein, membrane fusion protein (MFP) family protein K01993 - - 0.00000000000000000000000001197 120.0
HKD2_k127_4193034_2 methyltransferase activity - - - 0.00000000001391 74.0
HKD2_k127_4223355_0 Phage Terminase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 338.0
HKD2_k127_422532_0 PQQ enzyme repeat K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000001146 200.0
HKD2_k127_422532_1 SnoaL-like polyketide cyclase - - - 0.0003889 48.0
HKD2_k127_4235037_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 1.068e-216 679.0
HKD2_k127_4235037_1 Sugar (and other) transporter K08369 - - 0.0000000000001553 82.0
HKD2_k127_4235037_2 TetR family transcriptional regulator - - - 0.00000000001078 75.0
HKD2_k127_4251194_0 Glutamine synthetase type III K01915 - 6.3.1.2 0.0 1020.0
HKD2_k127_4251194_1 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.0000000000000326 74.0
HKD2_k127_4255937_0 PFAM glycosyl transferase family 2 K20534 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 365.0
HKD2_k127_4260839_0 lipid-transfer protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008113 462.0
HKD2_k127_4260839_1 Rubredoxin-like zinc ribbon domain (DUF35_N) - - - 0.00000000000000000000000000000000000000001195 158.0
HKD2_k127_4263052_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006078 422.0
HKD2_k127_4263052_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 320.0
HKD2_k127_4270065_0 Natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003817 268.0
HKD2_k127_4279738_0 Putative modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000003071 188.0
HKD2_k127_4279738_1 metallopeptidase activity K03592 - - 0.000000000000000523 87.0
HKD2_k127_4282929_0 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 583.0
HKD2_k127_4282929_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000006964 54.0
HKD2_k127_4298117_0 ATP synthase alpha/beta family, beta-barrel domain K02412 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008168 387.0
HKD2_k127_4302061_0 Belongs to the peptidase S11 family K01286,K07258 GO:0003674,GO:0003824,GO:0004175,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000005101 235.0
HKD2_k127_4302061_1 Tetratricopeptide repeat - - - 0.00000005045 60.0
HKD2_k127_43088_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003251 274.0
HKD2_k127_43088_1 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003361 259.0
HKD2_k127_43088_2 PFAM Rhomboid family protein - - - 0.00000000000000000000000000000000000000000000000000006276 194.0
HKD2_k127_43088_3 helix_turn_helix, Lux Regulon K07684 - - 0.0001812 44.0
HKD2_k127_4310928_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K01719,K13542 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,4.1.1.37,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000142 387.0
HKD2_k127_4310928_1 Enoyl-CoA hydratase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000644 160.0
HKD2_k127_4331414_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 546.0
HKD2_k127_4394350_0 Hydrophobe amphiphile Efflux-1 (HAE1) family K03296,K19594 - - 2.631e-296 928.0
HKD2_k127_4412308_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 4.522e-265 831.0
HKD2_k127_4412308_1 response regulator - - - 0.0000000006458 60.0
HKD2_k127_4420227_0 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007887 342.0
HKD2_k127_4420227_1 COG1319 Aerobic-type carbon monoxide dehydrogenase middle subunit CoxM CutM homologs K03519,K11178 - 1.17.1.4,1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000101 282.0
HKD2_k127_4420227_2 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs K03518 - 1.2.5.3 0.00000000000000000000000000000004523 126.0
HKD2_k127_4427938_0 MaoC like domain - - - 0.0000000000000000000000000221 114.0
HKD2_k127_4427938_1 Major facilitator Superfamily - - - 0.000000006662 64.0
HKD2_k127_4433135_0 Male sterility protein K12454 - 5.1.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007809 268.0
HKD2_k127_4433135_1 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.0000000000000000000000000000000000000000000000000000000000000002822 224.0
HKD2_k127_443475_0 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 305.0
HKD2_k127_443475_1 acyl-CoA transferases carnitine dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000636 272.0
HKD2_k127_443475_2 acyl-CoA transferases carnitine dehydratase - - - 0.000000000000000000000000000000000000000000000000001513 190.0
HKD2_k127_443475_3 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000001273 167.0
HKD2_k127_443475_4 Rhodanese Homology Domain - - - 0.00000000000000000000000000002161 120.0
HKD2_k127_4445298_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 577.0
HKD2_k127_4445298_1 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.00000000000000000000000000007726 129.0
HKD2_k127_445400_0 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000000000000000000000002787 241.0
HKD2_k127_445400_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000001162 224.0
HKD2_k127_4456601_0 ATP dependent DNA ligase domain protein K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 588.0
HKD2_k127_4469159_0 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000004152 244.0
HKD2_k127_4469159_1 Bacterial regulatory protein, Fis family - - - 0.0001056 46.0
HKD2_k127_4474186_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 404.0
HKD2_k127_4474186_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002362 275.0
HKD2_k127_4474186_2 Putative modulator of DNA gyrase K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000006668 214.0
HKD2_k127_4474186_3 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000000000004628 185.0
HKD2_k127_4474186_4 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000002842 159.0
HKD2_k127_4484839_0 extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000001069 229.0
HKD2_k127_4489333_0 Transglycosylase associated protein - - - 0.00000000000000002249 84.0
HKD2_k127_4506587_0 Belongs to the CarB family K01955 - 6.3.5.5 1.59e-254 801.0
HKD2_k127_4506587_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000001769 73.0
HKD2_k127_4507726_0 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001683 248.0
HKD2_k127_4507726_1 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000006413 158.0
HKD2_k127_4507726_2 lactoylglutathione lyase activity K08234 - - 0.0000002632 52.0
HKD2_k127_4529127_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004135 432.0
HKD2_k127_4529127_1 - - - - 0.00000000000000000000000000000000000000004039 157.0
HKD2_k127_4530353_0 Metal-dependent phosphohydrolase K07037 - - 0.0000000000000000000000000000000000005859 153.0
HKD2_k127_4553744_0 CoA binding domain - - - 9.944e-295 913.0
HKD2_k127_4553744_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006115 299.0
HKD2_k127_4563200_0 Epoxide hydrolase N terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 492.0
HKD2_k127_4563200_1 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000005273 191.0
HKD2_k127_4563200_2 Tetratricopeptide repeat - - - 0.000000000005084 76.0
HKD2_k127_4569361_0 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000001177 142.0
HKD2_k127_4575781_0 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000004581 112.0
HKD2_k127_4575781_1 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.0000000000000000002629 88.0
HKD2_k127_4575781_2 von Willebrand factor (vWF) type A domain K07114 - - 0.000000000000002219 83.0
HKD2_k127_4612026_0 PFAM sigma-54 factor interaction domain-containing protein K02584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 349.0
HKD2_k127_4627924_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate K03701 - - 1.695e-261 820.0
HKD2_k127_4647188_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002452 272.0
HKD2_k127_4647188_1 Macrocin-O-methyltransferase (TylF) - - - 0.00000000004183 74.0
HKD2_k127_4653809_0 SMP-30/Gluconolaconase/LRE-like region K01053 - 3.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 376.0
HKD2_k127_4653809_1 transmembrane transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 304.0
HKD2_k127_4653809_2 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000008684 190.0
HKD2_k127_4653809_3 domain, Protein - - - 0.00000000002958 64.0
HKD2_k127_4658704_0 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004168 397.0
HKD2_k127_4658704_1 Protein of unknown function (DUF1501) - - - 0.00001617 50.0
HKD2_k127_4674533_0 Belongs to the DegT DnrJ EryC1 family K16436 - 2.6.1.106 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 372.0
HKD2_k127_4675763_0 ZIP Zinc transporter K07238 - - 0.000000000000000000000000000000000000000000001678 173.0
HKD2_k127_4675763_1 DNA recombination-mediator protein A K04096 - - 0.0000000000000004786 83.0
HKD2_k127_4675763_2 Biotin carboxylase C-terminal domain K01968 - 6.4.1.4 0.000000000001218 74.0
HKD2_k127_4675763_3 'Cold-shock' DNA-binding domain K03704 - - 0.0000000001202 65.0
HKD2_k127_4675763_5 Protein of unknown function (DUF455) - - - 0.000002366 57.0
HKD2_k127_4683210_0 exo-alpha-(2->6)-sialidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 293.0
HKD2_k127_4697901_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 417.0
HKD2_k127_4697901_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000026 162.0
HKD2_k127_470950_0 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 0.00000000000000000000000000000000000000000004925 163.0
HKD2_k127_470950_1 AAA domain - - - 0.00000000000000000000000000000001971 140.0
HKD2_k127_470950_2 Cupin domain - - - 0.000000000000000000005855 98.0
HKD2_k127_4711243_0 alcohol dehydrogenase K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 349.0
HKD2_k127_4711243_1 NUDIX domain K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000000000002027 179.0
HKD2_k127_4711243_2 DegT/DnrJ/EryC1/StrS aminotransferase family K00812,K10907 - 2.6.1.1 0.00003149 46.0
HKD2_k127_4723800_0 MMPL family K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003111 258.0
HKD2_k127_4756074_0 UDP-glucoronosyl and UDP-glucosyl transferase - - - 0.00000000000000000000000000000000000000000000004202 174.0
HKD2_k127_4788497_0 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.000000000000000000000000000000000000000001833 169.0
HKD2_k127_4788497_1 Luciferase-like monooxygenase - - - 0.000000000000000000000003336 108.0
HKD2_k127_4788497_2 MAATS-type transcriptional repressor, C-terminal region K03577 - - 0.00000000001749 73.0
HKD2_k127_4788497_3 Radical SAM domain - - - 0.00000002157 56.0
HKD2_k127_4794532_0 Sodium/calcium exchanger protein K07300 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 368.0
HKD2_k127_4800046_0 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 359.0
HKD2_k127_4800046_1 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004265 321.0
HKD2_k127_4800046_2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000007735 247.0
HKD2_k127_4800046_3 Tellurite resistance protein TehB - - - 0.000000003952 63.0
HKD2_k127_4821579_0 CoA-transferase family III K07749,K08298 - 2.8.3.16,2.8.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004548 350.0
HKD2_k127_4821579_1 glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000003977 173.0
HKD2_k127_4824729_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005417 324.0
HKD2_k127_4824729_1 TIGRFAM Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000005718 192.0
HKD2_k127_4824729_2 Protein of unknown function (DUF465) K09794 - - 0.00000000003554 65.0
HKD2_k127_483577_0 NAD binding K00333,K13378 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 486.0
HKD2_k127_483577_1 transmembrane transporter activity K05820 - - 0.0000000000000000000000000000000000000000000000000003553 202.0
HKD2_k127_483577_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000006685 160.0
HKD2_k127_483577_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K02573 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000001058 156.0
HKD2_k127_483577_4 Thioredoxin-like [2Fe-2S] ferredoxin K00334,K00335 - 1.6.5.3 0.0000000000000000000000000000002426 128.0
HKD2_k127_483577_5 formate dehydrogenase K00123 - 1.17.1.9 0.000000000000000003815 92.0
HKD2_k127_4837580_0 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000001506 244.0
HKD2_k127_4837580_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.0006317 43.0
HKD2_k127_4843933_0 Acetyl-CoA acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 508.0
HKD2_k127_4843933_1 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000002566 188.0
HKD2_k127_4843933_2 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.0000000000000000000000000000000000000003398 153.0
HKD2_k127_4855657_0 Hydantoinase/oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008331 396.0
HKD2_k127_4855657_1 PQQ-like domain - - - 0.000000000000000000000000000000000000004873 149.0
HKD2_k127_4859175_0 glutamate--cysteine ligase K01919 - 6.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 383.0
HKD2_k127_4859175_1 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.0000000000000000000000000000000000000000000000000000000008968 206.0
HKD2_k127_4859175_2 Belongs to the FPP GGPP synthase family K00805 - 2.5.1.30 0.00000000000000000000000000000000000000000000000007375 190.0
HKD2_k127_4859175_3 Domain present in PSD-95, Dlg, and ZO-1/2. K02452 - - 0.00000000000000000002898 101.0
HKD2_k127_4863112_0 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001584 277.0
HKD2_k127_4863112_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001099 275.0
HKD2_k127_4863112_2 Amidase K01426 - 3.5.1.4 0.000001669 53.0
HKD2_k127_4887249_0 gluconolactonase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 478.0
HKD2_k127_4887249_1 Acetyl-CoA hydrolase/transferase N-terminal domain - - - 0.00000000000000000000000000000000000000000009747 165.0
HKD2_k127_4893736_0 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 292.0
HKD2_k127_4893736_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000002488 265.0
HKD2_k127_4893736_2 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000001834 176.0
HKD2_k127_4893736_3 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000007416 131.0
HKD2_k127_4893736_4 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.0000000000108 65.0
HKD2_k127_4893736_5 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00001591 47.0
HKD2_k127_4895861_0 Biotin carboxylase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007086 304.0
HKD2_k127_4913908_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 335.0
HKD2_k127_4913908_1 pyridoxamine 5'-phosphate K07005 - - 0.00000000000000000000000000000000006039 138.0
HKD2_k127_4914617_0 RNA polymerase beta subunit external 1 domain K03043 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 518.0
HKD2_k127_4914617_1 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000000000003411 155.0
HKD2_k127_4930804_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086,K03089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 295.0
HKD2_k127_4930804_1 short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000001895 179.0
HKD2_k127_4930804_2 FAD synthase K00953,K15429 GO:0003674,GO:0003824,GO:0003919,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042726,GO:0042727,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046443,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0070566,GO:0071704,GO:0071944,GO:0072387,GO:0072388,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.228,2.7.7.2 0.0000000000000000000000000000000000000000000009814 170.0
HKD2_k127_4930804_3 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000001188 83.0
HKD2_k127_4942356_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 461.0
HKD2_k127_4942356_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008937 322.0
HKD2_k127_4942356_2 Acetyl xylan esterase (AXE1) K06889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002372 254.0
HKD2_k127_4945684_0 belongs to the aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 580.0
HKD2_k127_4945684_1 domain protein K03750,K07219 - 2.10.1.1 0.000000000000000001993 90.0
HKD2_k127_4951717_0 [2Fe-2S] binding domain K03518,K13483 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000405 206.0
HKD2_k127_4951717_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K11177 - 1.17.1.4 0.000000000000000000000000000000000000000000000000006843 190.0
HKD2_k127_4951717_2 acetyltransferase - - - 0.0000000555 63.0
HKD2_k127_49523_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005705 285.0
HKD2_k127_49523_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000001789 224.0
HKD2_k127_49523_2 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000001879 187.0
HKD2_k127_4955147_0 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000003471 233.0
HKD2_k127_4970658_0 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000005924 185.0
HKD2_k127_4970658_1 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.000000000000000000000000007332 113.0
HKD2_k127_4970658_2 YGGT family K02221 - - 0.00000000000000000000000966 104.0
HKD2_k127_4970658_3 Putative regulatory protein - - - 0.00000000003078 64.0
HKD2_k127_4970658_4 Belongs to the UPF0235 family K09131 - - 0.00002835 50.0
HKD2_k127_4975157_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 537.0
HKD2_k127_4975157_1 Putative methyltransferase K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.0000000000000000000000000002749 123.0
HKD2_k127_4975157_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000001231 123.0
HKD2_k127_4975157_3 Domain of unknown function (DUF1877) - - - 0.000000000000000000000002659 112.0
HKD2_k127_4982339_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 538.0
HKD2_k127_4982339_1 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.0000000000000000000000000000001604 125.0
HKD2_k127_4982339_2 TIGRFAM Addiction module antidote protein, HigA K21498 - - 0.0000004986 51.0
HKD2_k127_4982597_0 ACT domain K00928 GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000005251 224.0
HKD2_k127_4982597_1 Hydrolase, P-loop family K06925 - - 0.000000005514 59.0
HKD2_k127_5003968_0 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008146 286.0
HKD2_k127_5003968_1 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003832 279.0
HKD2_k127_5003968_2 transferase activity, transferring glycosyl groups - - - 0.0000002088 55.0
HKD2_k127_5004453_0 III protein, CoA-transferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 505.0
HKD2_k127_5004453_1 Catalyzes the conversion of L-lactate to pyruvate. Is coupled to the respiratory chain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004762 408.0
HKD2_k127_5010269_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006649 312.0
HKD2_k127_5013711_0 Uncharacterized small protein (DUF2292) - - - 0.000002566 51.0
HKD2_k127_5031953_0 lactate metabolic process K00113 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000005646 236.0
HKD2_k127_5031953_1 Protein of unknown function (DUF3501) - - - 0.0000000000000000000000000000000000000002474 156.0
HKD2_k127_5038767_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006021 289.0
HKD2_k127_5038767_1 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000000000000007932 132.0
HKD2_k127_5038767_2 PFAM zinc finger, DksA TraR C4-type K06204 - - 0.000000000000000000004672 98.0
HKD2_k127_5045131_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 439.0
HKD2_k127_5045131_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000007397 100.0
HKD2_k127_5045131_2 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.0000000000000000000001209 102.0
HKD2_k127_5057855_0 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.00000000000000000000000000000000000000000004662 166.0
HKD2_k127_5057855_1 MoaE protein K03635,K03636,K03637,K03752,K21142 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.7.7.77,2.8.1.12,4.6.1.17 0.000000000000000000000000000000000002927 143.0
HKD2_k127_5080871_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003868 323.0
HKD2_k127_510379_0 Electron transfer flavoprotein K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 338.0
HKD2_k127_510379_1 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005214 283.0
HKD2_k127_510379_2 PFAM periplasmic binding protein K02016 - - 0.000000000000000000004853 98.0
HKD2_k127_5117513_0 Bacterial protein of unknown function (DUF885) - - - 1.328e-221 697.0
HKD2_k127_5118529_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 3.505e-202 641.0
HKD2_k127_5129143_0 COG3668 Plasmid stabilization system protein K19092 - - 0.00000000000000000000000000001731 122.0
HKD2_k127_5129143_1 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain K07746 - - 0.000000000000000000006651 96.0
HKD2_k127_5129143_2 Major Facilitator Superfamily K08151 - - 0.000000000000000009281 91.0
HKD2_k127_5129143_3 membrane K08973 - - 0.00003453 51.0
HKD2_k127_5134783_0 Metallophosphoesterase, calcineurin superfamily - - - 0.0000000000000000000000000000000000000000000000000000000008431 211.0
HKD2_k127_5134783_1 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000003746 164.0
HKD2_k127_5134783_2 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E K07025 - - 0.0000000000000000000000000000000001297 140.0
HKD2_k127_5134783_3 COG0346 Lactoylglutathione lyase and related lyases K05606 - 5.1.99.1 0.00000000000001498 84.0
HKD2_k127_5134783_4 Glyoxalase-like domain K01759,K05606 - 4.4.1.5,5.1.99.1 0.00000000000002018 83.0
HKD2_k127_5138250_0 transferase activity, transferring glycosyl groups K00713,K03280 - 2.4.1.56 0.00000000000000000000000000000000000000000000000000000000000000000003595 244.0
HKD2_k127_5138250_1 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001615 235.0
HKD2_k127_5173871_0 PFAM Sulfate transporter antisigma-factor antagonist STAS - - - 8.116e-220 694.0
HKD2_k127_5176062_0 glutathione-regulated potassium exporter activity K03455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000859 441.0
HKD2_k127_5176062_1 Class ii aldolase K01628 - 4.1.2.17 0.00000000000001225 81.0
HKD2_k127_5176062_2 Putative methyltransferase - - - 0.00001963 47.0
HKD2_k127_5206923_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009257 271.0
HKD2_k127_5206923_1 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000401 121.0
HKD2_k127_5206923_2 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000002184 100.0
HKD2_k127_5206923_3 Glycosyltransferase Family 4 - - - 0.0000000006599 69.0
HKD2_k127_5225089_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006136 519.0
HKD2_k127_5225089_1 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000005797 223.0
HKD2_k127_5260089_0 Putative modulator of DNA gyrase K03568 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 458.0
HKD2_k127_5260089_1 Putative modulator of DNA gyrase K03592 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000286 190.0
HKD2_k127_5260736_0 TrkA-C domain K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003024 270.0
HKD2_k127_5260736_1 CoA-transferase family III - - - 0.00000000000000000000000000000001224 135.0
HKD2_k127_5260921_0 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 357.0
HKD2_k127_5260921_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000001566 194.0
HKD2_k127_5269121_0 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002718 285.0
HKD2_k127_5269121_1 Putative esterase - - - 0.0001073 46.0
HKD2_k127_5269121_2 Sigma-70, region 4 K03088 - - 0.0007259 45.0
HKD2_k127_5275361_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005596 357.0
HKD2_k127_5283603_0 PFAM binding-protein-dependent transport systems inner membrane component K02018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000124 277.0
HKD2_k127_5283603_1 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 0.00000000000000000000000000000000002935 140.0
HKD2_k127_5283603_2 Bacterial extracellular solute-binding protein K02020 - - 0.0000000000000000004806 89.0
HKD2_k127_5289005_0 acetyl-coa acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006068 295.0
HKD2_k127_5289005_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006893 264.0
HKD2_k127_5289005_2 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000002012 157.0
HKD2_k127_5289005_3 nucleic-acid-binding protein containing a Zn-ribbon K07068 - - 0.000000000000000000000000000000000007367 141.0
HKD2_k127_5290154_0 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008108 260.0
HKD2_k127_5290154_1 CoA-transferase family III - - - 0.000000000000000006675 91.0
HKD2_k127_5296950_0 AhpC/TSA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007588 423.0
HKD2_k127_5296950_1 - - - - 0.000000000000000000000000000005831 122.0
HKD2_k127_5296950_2 - - - - 0.000000000000000000007998 93.0
HKD2_k127_5296950_3 alcohol dehydrogenase K13953 - 1.1.1.1 0.000000000000000000505 87.0
HKD2_k127_5303465_0 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009885 477.0
HKD2_k127_5303465_1 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000007334 172.0
HKD2_k127_5303465_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000001973 120.0
HKD2_k127_5303465_3 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000009032 90.0
HKD2_k127_5303465_4 - - - - 0.000001792 50.0
HKD2_k127_5309845_0 Sodium Bile acid symporter family K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004872 477.0
HKD2_k127_5309845_1 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 303.0
HKD2_k127_5309845_2 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.00000000000000000000001402 100.0
HKD2_k127_5318214_0 Rieske [2Fe-2S] domain K03862,K18068 - 1.14.12.7,1.14.13.82 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 475.0
HKD2_k127_5318214_1 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000003807 135.0
HKD2_k127_5318214_2 Protein of unknown function (DUF1329) - - - 0.000000000647 71.0
HKD2_k127_5334825_0 PFAM 4-hydroxyphenylacetate 3-hydroxylase K00483 - 1.14.14.9 1.338e-241 754.0
HKD2_k127_5334825_1 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.000000000000001057 79.0
HKD2_k127_534454_0 PFAM Diacylglycerol kinase, catalytic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 327.0
HKD2_k127_534454_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004903 323.0
HKD2_k127_534454_2 N-acyl-D-aspartate D-glutamate deacylase - - - 0.00000000000000000000000000000000000000000000000000003266 195.0
HKD2_k127_5362539_0 Glutathione S-transferase K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002315 263.0
HKD2_k127_5362539_1 Winged helix-turn-helix DNA-binding - - - 0.0000000000000000000000000000000124 130.0
HKD2_k127_5367371_0 Methylmalonyl-CoA mutase K14447 - 5.4.99.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 304.0
HKD2_k127_5372170_0 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008045 344.0
HKD2_k127_5372170_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001834 274.0
HKD2_k127_5372170_2 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000001528 171.0
HKD2_k127_5372170_3 PFAM zinc finger, DksA TraR C4-type K06204 - - 0.000000000000000000000000000000001083 134.0
HKD2_k127_5374729_0 PFAM acyl-CoA dehydrogenase domain protein K00255,K11731 - 1.3.8.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 326.0
HKD2_k127_5410133_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000004572 207.0
HKD2_k127_5441103_0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K14751 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005423 403.0
HKD2_k127_5441103_1 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000001825 179.0
HKD2_k127_5441103_2 Major Facilitator Superfamily K08223 - - 0.000000000000000000000000002366 114.0
HKD2_k127_5457382_0 CoA-transferase family III K18702 - 2.8.3.19 0.000000000000000000000000000000000000002107 154.0
HKD2_k127_5457382_1 transferase - - - 0.00000000000004836 73.0
HKD2_k127_5461204_0 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 351.0
HKD2_k127_5461204_1 L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000001065 54.0
HKD2_k127_5466847_0 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006559 581.0
HKD2_k127_5476018_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.000000000000000000000000000000000000000006391 160.0
HKD2_k127_5476018_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000001553 110.0
HKD2_k127_5484285_0 Bacterial membrane protein YfhO - - - 0.00000000000000000000000000000000000000000000000000000000003279 221.0
HKD2_k127_5502996_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 5.883e-208 658.0
HKD2_k127_5506849_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008808 478.0
HKD2_k127_5506849_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 430.0
HKD2_k127_5506849_2 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000000000000000000002185 241.0
HKD2_k127_5506849_3 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.227 0.00000000000002333 76.0
HKD2_k127_5507602_0 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000652 584.0
HKD2_k127_5512956_0 DNA integration - - - 0.00000000000000000000000000000000000000000000000000000000001162 219.0
HKD2_k127_551346_0 Dehydrogenase K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000029 286.0
HKD2_k127_551346_1 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000001631 66.0
HKD2_k127_551346_2 sequence-specific DNA binding - - - 0.000000004871 61.0
HKD2_k127_5515576_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008345 590.0
HKD2_k127_5515576_1 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000008557 217.0
HKD2_k127_5517444_0 aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 381.0
HKD2_k127_5517444_1 Glycolate oxidase subunit K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001948 281.0
HKD2_k127_5531233_0 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 392.0
HKD2_k127_5531233_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000001645 129.0
HKD2_k127_5540487_0 Bifunctional nuclease K03617,K08999 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000002133 162.0
HKD2_k127_5540487_1 Protein containing von Willebrand factor type A (VWA) domain K07161 - - 0.0000003075 52.0
HKD2_k127_5540487_2 Thioredoxin - - - 0.0003338 46.0
HKD2_k127_5540487_3 Tetratricopeptide repeat - - - 0.0003986 51.0
HKD2_k127_5547097_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 1.911e-217 689.0
HKD2_k127_5547097_1 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 574.0
HKD2_k127_5547097_2 - - - - 0.0000000000000000000000000000000000000000000000005346 181.0
HKD2_k127_5547097_3 luciferase - - - 0.0000000000000000000000000000000000000000000488 164.0
HKD2_k127_5561390_0 Evidence 5 No homology to any previously reported sequences - - - 0.0000000008015 68.0
HKD2_k127_5561390_1 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000001197 58.0
HKD2_k127_5561390_2 FR47-like protein K02348 GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 - 0.00004244 52.0
HKD2_k127_5561390_3 Divergent 4Fe-4S mono-cluster - - - 0.0002187 46.0
HKD2_k127_55776_0 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008374 350.0
HKD2_k127_5581092_0 Oxidoreductase NAD-binding domain K00380,K02641,K14338 - 1.14.14.1,1.18.1.2,1.6.2.4,1.8.1.2 9.968e-270 847.0
HKD2_k127_5595986_0 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.000000000000000000000000000000000000000000000000000000000000000000003808 244.0
HKD2_k127_5595986_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000008504 179.0
HKD2_k127_5595986_2 UDP-3-O-acyl N-acetylglycosamine deacetylase K02535,K13599 - 3.5.1.108 0.0000000000000000000001206 98.0
HKD2_k127_5599113_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 1.068e-259 823.0
HKD2_k127_5599113_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 286.0
HKD2_k127_5599113_2 Universal stress protein - - - 0.00000000003684 66.0
HKD2_k127_5601487_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005308 430.0
HKD2_k127_5601487_1 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000005158 175.0
HKD2_k127_5627356_0 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 343.0
HKD2_k127_5627356_1 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000004387 149.0
HKD2_k127_5627356_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.00000000000000000000000000002793 119.0
HKD2_k127_563016_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 441.0
HKD2_k127_563016_1 Enoyl-CoA hydratase/isomerase K20765 - 3.7.1.18 0.00000000000000000000000000000000000000000000000000000000000000002947 228.0
HKD2_k127_5634587_0 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 335.0
HKD2_k127_5639951_0 DSBA-like thioredoxin domain - - - 0.000000000000000000000000000000000000000002487 163.0
HKD2_k127_5639951_1 Thioesterase - - - 0.0000000000000000000000000000009682 126.0
HKD2_k127_5639951_2 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000002656 112.0
HKD2_k127_564126_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 356.0
HKD2_k127_564126_1 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000002756 168.0
HKD2_k127_5646691_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002129 277.0
HKD2_k127_5646691_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000003313 73.0
HKD2_k127_5669084_0 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000004746 235.0
HKD2_k127_5669084_1 Male sterility protein K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000781 191.0
HKD2_k127_5669084_2 FtsX-like permease family - - - 0.00000000000000000000000000000000000000005638 157.0
HKD2_k127_5681130_0 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.0000000000000000000000000000000000000000006885 169.0
HKD2_k127_5681130_1 Amidohydrolase family - - - 0.0000000000000000000000001846 112.0
HKD2_k127_5681130_2 - - - - 0.000000000005376 66.0
HKD2_k127_568934_0 UvrD/REP helicase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001581 499.0
HKD2_k127_5702049_0 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000003103 197.0
HKD2_k127_5702049_1 PFAM Acyltransferase - - - 0.00000000000000000000000000000000000000000000000000007058 192.0
HKD2_k127_570502_0 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000006372 256.0
HKD2_k127_570502_1 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000000000000000000000000000000001758 153.0
HKD2_k127_570502_2 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000007979 149.0
HKD2_k127_570502_3 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.00000005855 57.0
HKD2_k127_5718273_0 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 330.0
HKD2_k127_5718273_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000113 213.0
HKD2_k127_5718273_2 regulatory protein IclR - - - 0.000000000000000000000000000000000000000000000000000000004023 204.0
HKD2_k127_5718273_3 Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000005274 189.0
HKD2_k127_5718273_4 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000001326 149.0
HKD2_k127_5721644_0 GIY-YIG type nucleases (URI domain) K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.0000000000000000000000000000001741 129.0
HKD2_k127_5721644_1 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.000000000000000000000000006075 123.0
HKD2_k127_5722297_0 protein-disulfide reductase activity K04084 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000674 277.0
HKD2_k127_5722297_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000192 239.0
HKD2_k127_5738003_0 Amidohydrolase family - - - 0.00000000000000000000000000000002215 141.0
HKD2_k127_5738003_1 regulation of response to stimulus K13730 - - 0.000000000000001847 89.0
HKD2_k127_5757450_0 phosphatidylethanolamine metabolic process K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000001732 174.0
HKD2_k127_5757450_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000009906 93.0
HKD2_k127_5774253_0 Asparaginyl-tRNA synthetase K01893 GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 285.0
HKD2_k127_5774253_1 PrpF protein K09788 - - 0.000000000000000000000000000000000000000000000000000000000547 208.0
HKD2_k127_5792915_0 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 6.536e-204 638.0
HKD2_k127_5792915_1 Acyl-CoA dehydrogenase, C-terminal domain K04117 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 401.0
HKD2_k127_5792915_2 depolymerase - - - 0.000000000000000000000000000000000000000002371 168.0
HKD2_k127_5792915_3 PFAM MaoC like domain - - - 0.000000000000000000000000000000000000006951 155.0
HKD2_k127_5792915_4 TonB dependent receptor - - - 0.00000000000000000000000000000000000001438 153.0
HKD2_k127_5803168_0 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005491 300.0
HKD2_k127_5803168_1 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000000006409 161.0
HKD2_k127_5803168_2 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000003216 159.0
HKD2_k127_5803168_3 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000000000000000000000000001572 151.0
HKD2_k127_5803168_4 Protein of unknown function (DUF1646) - - - 0.0000000000000000826 87.0
HKD2_k127_5803168_5 Amino acid permease - - - 0.0000000001486 69.0
HKD2_k127_5803168_6 PFAM Protein-tyrosine phosphatase, low molecular weight K01104,K20201 - 3.1.3.48,3.9.1.2 0.00000000229 65.0
HKD2_k127_5807553_0 Multicopper oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000482 506.0
HKD2_k127_5807553_1 Glutathione S-transferase, C-terminal domain K11209 - - 0.000000000000000000000000000000000000000000000001249 175.0
HKD2_k127_5809165_0 ABC transporter K02013 - 3.6.3.34 0.00000000000000000000000000000000000000000000000000000000000000002696 237.0
HKD2_k127_5809165_1 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000006628 231.0
HKD2_k127_5809165_2 PFAM Haloacid dehalogenase domain protein hydrolase K07025 - - 0.000000000000000000000000000000000000000000000000004062 190.0
HKD2_k127_5809165_3 Periplasmic binding protein K02016 - - 0.000000000000000006067 91.0
HKD2_k127_5809165_4 PFAM metallophosphoesterase K07098 - - 0.0000001562 57.0
HKD2_k127_5817555_0 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001358 307.0
HKD2_k127_5817555_2 - - - - 0.000000001536 70.0
HKD2_k127_585182_0 Putative glutamine amidotransferase - - - 0.0000000000000000000000000000000000000000000000000000002455 210.0
HKD2_k127_5874252_0 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000007285 211.0
HKD2_k127_5874252_1 Iron-binding zinc finger CDGSH type K05710 - - 0.000000000000000004787 89.0
HKD2_k127_5874252_2 carboxylic ester hydrolase activity K01998 - - 0.000000003183 64.0
HKD2_k127_5935731_0 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005267 359.0
HKD2_k127_5935731_1 Belongs to the radical SAM superfamily. PqqE family K06139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004047 250.0
HKD2_k127_593718_0 Putative modulator of DNA gyrase K03592 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000421 292.0
HKD2_k127_593718_1 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000034 268.0
HKD2_k127_593718_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000003383 119.0
HKD2_k127_593718_3 Crp Fnr family K21564 - - 0.000000000000001257 86.0
HKD2_k127_5960860_0 Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 313.0
HKD2_k127_5960860_1 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000009116 101.0
HKD2_k127_5966607_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 569.0
HKD2_k127_5990022_0 TIM-barrel fold metal-dependent hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001521 256.0
HKD2_k127_5990022_1 Cupin 2 conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000003397 229.0
HKD2_k127_5990389_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000004174 193.0
HKD2_k127_5990389_1 - - - - 0.00000000000000000000000000004792 123.0
HKD2_k127_5994426_0 TIGRFAM fructose-1,6-bisphosphatase, class II K02446 - 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005404 359.0
HKD2_k127_5994426_1 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000003186 138.0
HKD2_k127_5994426_2 Protein of unknown function (DUF429) - - - 0.00000000008532 63.0
HKD2_k127_6025319_0 PFAM TPR repeat-containing protein - - - 0.0001678 53.0
HKD2_k127_6041596_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004742 346.0
HKD2_k127_6041596_1 Belongs to the SAICAR synthetase family K01923 - 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000393 235.0
HKD2_k127_6042599_0 alcohol dehydrogenase K00121 - 1.1.1.1,1.1.1.284 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003522 376.0
HKD2_k127_6042599_1 Enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 331.0
HKD2_k127_6042599_2 Flavin-binding monooxygenase-like - - - 0.0000000001533 62.0
HKD2_k127_6042599_3 Gamma-glutamyl cyclotransferase, AIG2-like - - - 0.0000292 51.0
HKD2_k127_6043663_0 PFAM ABC transporter related K06861 - - 0.000000000000000000000000000000000000000003743 158.0
HKD2_k127_6043663_1 - - - - 0.0000000000000006372 78.0
HKD2_k127_6058180_0 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000000000002474 156.0
HKD2_k127_6058180_1 Protein of unknown function (DUF2889) K07053 - 3.1.3.97 0.000000000000000000000000000000009152 138.0
HKD2_k127_606079_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001488 269.0
HKD2_k127_606079_1 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000001634 194.0
HKD2_k127_6061251_0 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000002429 214.0
HKD2_k127_6061251_1 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000003836 126.0
HKD2_k127_6061251_2 associated with various cellular activities - - - 0.00000000000000000000000000003715 119.0
HKD2_k127_6061251_3 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000004637 65.0
HKD2_k127_6068845_0 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 383.0
HKD2_k127_6096068_0 Associated with various cellular activities K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 322.0
HKD2_k127_6096068_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000001139 189.0
HKD2_k127_6096068_2 protein some members contain a von Willebrand factor type A - - - 0.0000000000000000000000000000003161 134.0
HKD2_k127_6096068_3 - - - - 0.000000000000000000000000000007415 130.0
HKD2_k127_6096068_4 Aerotolerance regulator N-terminal - - - 0.00002395 55.0
HKD2_k127_6104576_0 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 304.0
HKD2_k127_6104576_1 ThiF family K03148,K21147 - 2.7.7.73,2.7.7.80,2.8.1.11 0.00000000000000000000000000000000000000000000001536 178.0
HKD2_k127_6114666_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003078 289.0
HKD2_k127_6114666_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0000000000000000000000000001649 117.0
HKD2_k127_6123315_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 7.505e-236 742.0
HKD2_k127_6134880_0 PFAM PhoH family protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 370.0
HKD2_k127_6141433_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005947 411.0
HKD2_k127_6163717_0 Coenzyme A transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000174 273.0
HKD2_k127_6163717_1 Enoyl-CoA hydratase/isomerase K20765 - 3.7.1.18 0.0000000000000000000000000000000000000000000000000000000001794 212.0
HKD2_k127_6194403_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004571 346.0
HKD2_k127_6194403_1 Glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000001451 213.0
HKD2_k127_6198851_0 PFAM FAD linked oxidase domain protein K00803 - 2.5.1.26 2.332e-214 677.0
HKD2_k127_6198851_1 hydrolase activity, acting on ester bonds K01563 - 3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005013 420.0
HKD2_k127_6198851_2 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002151 270.0
HKD2_k127_6198851_3 F420H(2)-dependent quinone reductase - - - 0.00000000000000000000000000008282 121.0
HKD2_k127_6218287_0 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000002053 144.0
HKD2_k127_6218287_1 Amidohydrolase - - - 0.00000000000000000000000005729 114.0
HKD2_k127_6221030_0 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000426 346.0
HKD2_k127_6221030_1 - - - - 0.000000000000001078 87.0
HKD2_k127_6236211_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000003601 206.0
HKD2_k127_6236211_1 Removes 5-oxoproline from various penultimate amino acid residues except L-proline K01304 - 3.4.19.3 0.00000000000000000000000000000000000000000004243 168.0
HKD2_k127_6248217_0 CoA-transferase family III - - - 0.00000000000000000000000002344 115.0
HKD2_k127_6248217_1 HEAT repeat - - - 0.0000006942 58.0
HKD2_k127_6251759_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000372 595.0
HKD2_k127_6251759_1 Alpha/beta hydrolase family K07020 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001043 261.0
HKD2_k127_6251759_2 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000000004 237.0
HKD2_k127_6251759_3 PFAM Inward rectifier potassium channel K08715 - - 0.000000000000000000000000000000000000000000000000000000000000000002342 239.0
HKD2_k127_6257466_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000154 205.0
HKD2_k127_6257466_1 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000001415 133.0
HKD2_k127_625995_0 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001928 270.0
HKD2_k127_625995_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000242 252.0
HKD2_k127_6284575_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 517.0
HKD2_k127_6284575_1 ACT domain K01653 - 2.2.1.6 0.00000000000000000000000000000000006158 135.0
HKD2_k127_6333321_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 452.0
HKD2_k127_6333321_1 PIN domain - - - 0.000000000000000000000000000000004387 133.0
HKD2_k127_6333321_2 Zn peptidase - - - 0.0000000000000001539 89.0
HKD2_k127_6340809_0 PFAM response regulator receiver K02282 - - 0.000000000000000000004734 106.0
HKD2_k127_6356329_0 Cellulose biosynthesis protein BcsQ K03496 GO:0008150,GO:0022603,GO:0042173,GO:0042174,GO:0043937,GO:0043939,GO:0045595,GO:0045596,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051093,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000004612 219.0
HKD2_k127_6356329_1 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000005894 194.0
HKD2_k127_6365012_0 alcohol dehydrogenase K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006362 465.0
HKD2_k127_6365012_1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 0.000000000000000005182 95.0
HKD2_k127_6369687_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 387.0
HKD2_k127_6391965_0 PFAM major facilitator superfamily MFS_1 K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 323.0
HKD2_k127_6391965_1 PFAM Colicin V production protein K03558 - - 0.0000002068 60.0
HKD2_k127_6391965_2 Belongs to the thioredoxin family K03671 - - 0.00001275 47.0
HKD2_k127_6393970_0 ferredoxin-NADP+ reductase activity K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000198 278.0
HKD2_k127_6393970_1 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000000007614 195.0
HKD2_k127_6393970_2 SAM-dependent methyltransferase K06969 - 2.1.1.191 0.000000000165 64.0
HKD2_k127_6433894_0 TIGRFAM tyrosine recombinase XerD K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006748 252.0
HKD2_k127_6433894_1 COG1994 Zn-dependent proteases - - - 0.0000000000000000000000000000000000000000000000001333 185.0
HKD2_k127_6433894_2 Segregation and condensation protein ScpA K05896 - - 0.000000000000000000000000000000005766 132.0
HKD2_k127_6433894_3 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.00000000000000000000002229 103.0
HKD2_k127_6444416_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006028 346.0
HKD2_k127_6449667_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 5.313e-240 769.0
HKD2_k127_6451155_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005511 393.0
HKD2_k127_6451155_1 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001061 289.0
HKD2_k127_6451155_2 Ribulose-phosphate 3 epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.00000000000000000000000000000000000000002587 158.0
HKD2_k127_6451155_3 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000008728 112.0
HKD2_k127_6451155_4 Chromate transporter K07240 - - 0.000002042 52.0
HKD2_k127_6454826_0 short-chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001031 273.0
HKD2_k127_6454826_1 HpcH/HpaI aldolase/citrate lyase family - - - 0.000000000000000000000000000000000000005071 158.0
HKD2_k127_6454826_2 SnoaL-like domain K06893 - - 0.000000000000000002226 87.0
HKD2_k127_6461641_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000003468 192.0
HKD2_k127_6491405_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000518 550.0
HKD2_k127_6491405_1 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000314 244.0
HKD2_k127_6491405_2 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000002951 143.0
HKD2_k127_6497975_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 497.0
HKD2_k127_6497975_1 L,D-transpeptidase catalytic domain K16291 - - 0.0000003617 58.0
HKD2_k127_6508571_0 Male sterility protein K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000006763 244.0
HKD2_k127_6508918_0 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 406.0
HKD2_k127_6508918_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.000000000000000000000000634 108.0
HKD2_k127_6508918_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000005086 61.0
HKD2_k127_6509421_0 Telomere recombination K04656 - - 1.151e-195 635.0
HKD2_k127_6512165_0 Glycoprotease family K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009567 310.0
HKD2_k127_6512165_1 Ribosomal RNA adenine dimethylases K02528 - 2.1.1.182 0.0000000000002522 73.0
HKD2_k127_6526798_0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 326.0
HKD2_k127_6526798_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000777 143.0
HKD2_k127_6532942_0 Dehydrogenase E1 component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003124 333.0
HKD2_k127_6532942_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000003408 265.0
HKD2_k127_6533684_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002655 595.0
HKD2_k127_6533684_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000862 332.0
HKD2_k127_6533684_2 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.000000000000000000000000001309 120.0
HKD2_k127_6533684_3 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000003571 52.0
HKD2_k127_6547795_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004358 310.0
HKD2_k127_6547795_1 In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold. K02601 - - 0.000000000000000000000000000000000000000000000000000000000000000000003753 239.0
HKD2_k127_6547795_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000001684 220.0
HKD2_k127_6547795_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000006908 128.0
HKD2_k127_6547795_4 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000004189 71.0
HKD2_k127_6547795_5 - - - - 0.000003781 49.0
HKD2_k127_6547795_6 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.00002618 48.0
HKD2_k127_6553195_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000003119 173.0
HKD2_k127_6553195_1 Hypothetical methyltransferase K07755 - 2.1.1.137 0.0000000000000000000000000000000000575 134.0
HKD2_k127_6555104_0 penicillin binding K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.000000000000000000000000000000000000000000001953 171.0
HKD2_k127_6555104_1 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000001191 164.0
HKD2_k127_655701_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 364.0
HKD2_k127_6597939_0 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000001284 218.0
HKD2_k127_6597939_1 TIGRFAM iron-sulfur cluster binding protein K18929 - - 0.000000000000000000000000000000000000000000000000000001649 199.0
HKD2_k127_6597939_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.0000000000000000000000000000004543 126.0
HKD2_k127_6602181_0 pyruvate phosphate dikinase K01006 - 2.7.9.1 3.405e-208 660.0
HKD2_k127_6602181_1 PFAM peptidase S1 and S6 chymotrypsin Hap K04771 - 3.4.21.107 0.000000000001202 73.0
HKD2_k127_6602428_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 GO:0000096,GO:0000097,GO:0000098,GO:0003674,GO:0003824,GO:0004122,GO:0004124,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008134,GO:0008144,GO:0008150,GO:0008152,GO:0008284,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009087,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016835,GO:0016836,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0032991,GO:0032993,GO:0036094,GO:0042127,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043388,GO:0043436,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046983,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0051098,GO:0051099,GO:0051101,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051291,GO:0065003,GO:0065007,GO:0065009,GO:0070279,GO:0071704,GO:0071840,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1904796,GO:1904798,GO:2000677,GO:2000679 2.5.1.47 0.000000000000000000000000000000000000000000000000000008999 191.0
HKD2_k127_6602428_1 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.000000000002775 76.0
HKD2_k127_6622668_0 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009471 367.0
HKD2_k127_6622668_1 KR domain K00065 - 1.1.1.127 0.000000000000000000000000000000000000000000000000000000000000000000003279 243.0
HKD2_k127_6624455_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000003291 167.0
HKD2_k127_6624455_1 cellular response to heat K09807 - - 0.00000000000000000000000000000000006531 142.0
HKD2_k127_6624455_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000025 48.0
HKD2_k127_6625660_0 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 392.0
HKD2_k127_6625660_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000002445 177.0
HKD2_k127_6625660_2 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) - - - 0.00004861 51.0
HKD2_k127_6629513_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 3.77e-270 856.0
HKD2_k127_6629513_1 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 529.0
HKD2_k127_6629513_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000002515 193.0
HKD2_k127_6629513_3 Putative transmembrane protein (PGPGW) - - - 0.000000000006677 70.0
HKD2_k127_6629513_4 - - - - 0.00003453 46.0
HKD2_k127_6633582_0 TIGRFAM conserved - - - 0.00000000000000000000000000000000000000000006757 163.0
HKD2_k127_6633582_1 Luciferase-like monooxygenase - - - 0.000000000000008905 76.0
HKD2_k127_6633582_2 Thioredoxin - - - 0.0000001999 61.0
HKD2_k127_6650148_0 Carbon starvation protein K06200 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 470.0
HKD2_k127_6650148_1 PhoQ Sensor K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000743 128.0
HKD2_k127_6650861_0 Flavin-binding monooxygenase-like K14520 - 1.14.13.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009353 586.0
HKD2_k127_6659749_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005977 293.0
HKD2_k127_6659749_1 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.000000000000000000000000000000000000000000000000000000003132 203.0
HKD2_k127_6659749_2 Belongs to the HpcH HpaI aldolase family K01644,K08691 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006107,GO:0008150,GO:0008152,GO:0009987,GO:0015977,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0043167,GO:0043169,GO:0043427,GO:0043436,GO:0043648,GO:0044237,GO:0044281,GO:0046872,GO:0047777,GO:0050083,GO:0071704 4.1.3.24,4.1.3.25,4.1.3.34 0.0000000000000000000000000000000000000000000005572 179.0
HKD2_k127_6670480_0 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007143 358.0
HKD2_k127_6670480_1 Plasmid stabilization system K19092 - - 0.000000000000000000000005035 103.0
HKD2_k127_6670480_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000004214 63.0
HKD2_k127_6673132_0 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008867 359.0
HKD2_k127_6673132_1 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000001127 146.0
HKD2_k127_6673132_2 membrane K15977 - - 0.00000000000000000000000000008908 119.0
HKD2_k127_6697622_0 Sulfatase K01130 - 3.1.6.1 3.309e-256 794.0
HKD2_k127_6697622_1 Protein of unknown function (DUF3313) - - - 0.0000000000000000000000000000000000000000000000000000007592 201.0
HKD2_k127_6697622_2 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000002181 105.0
HKD2_k127_6697622_3 PFAM Glyoxalase bleomycin resistance protein dioxygenase K01759,K05606 - 4.4.1.5,5.1.99.1 0.00004741 51.0
HKD2_k127_6703089_0 Ammonia monooxygenase K10944 - 1.14.18.3,1.14.99.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 368.0
HKD2_k127_6703089_1 Ammonia monooxygenase/methane monooxygenase, subunit C K10946 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000024 287.0
HKD2_k127_6738457_0 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000007157 187.0
HKD2_k127_6738457_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000002968 177.0
HKD2_k127_6738457_2 Ribosomal proteins 50S L24/mitochondrial 39S L24 K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000002556 121.0
HKD2_k127_6761896_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00002443 47.0
HKD2_k127_6761896_1 - - - - 0.0002209 47.0
HKD2_k127_676672_0 protein some members contain a von Willebrand factor type A - - - 0.0000002755 59.0
HKD2_k127_676672_1 Aerotolerance regulator N-terminal - - - 0.0000006213 62.0
HKD2_k127_6791235_0 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000004287 227.0
HKD2_k127_6791235_1 regulator K07667 - - 0.000000000000000000000000000000000000000000004125 167.0
HKD2_k127_6823962_0 - - - - 0.000000000000000000000000000000000000000000000004637 174.0
HKD2_k127_6823962_1 CYTH - - - 0.000000000000000000000000000000000000000006924 159.0
HKD2_k127_6823962_2 Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.00000000000000000000000000000001273 136.0
HKD2_k127_6823962_3 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - GO:0003674,GO:0003824,GO:0016787,GO:0016817,GO:0016818 - 0.00000000000000000000000000000005238 134.0
HKD2_k127_683168_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003668 423.0
HKD2_k127_6841169_0 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 380.0
HKD2_k127_6841169_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000022 265.0
HKD2_k127_6841169_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000009827 228.0
HKD2_k127_6841169_3 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000006166 197.0
HKD2_k127_6841169_4 protein possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000000000002773 179.0
HKD2_k127_6841169_5 - - - - 0.00000001793 58.0
HKD2_k127_6841169_6 glutathione-regulated potassium exporter activity - - - 0.0000003431 52.0
HKD2_k127_6849116_0 SMART Elongator protein 3 MiaB NifB K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006555 381.0
HKD2_k127_6849116_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 367.0
HKD2_k127_6849116_2 phosphatase (DUF442) - - - 0.00008055 46.0
HKD2_k127_686656_0 von Willebrand factor, type A - - - 0.000000000000000000000000000000000000000000001256 183.0
HKD2_k127_6894754_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000714 423.0
HKD2_k127_6894754_1 Ribosomal protein L17 K02879 - - 0.000000000000000000000000000000000000000005354 157.0
HKD2_k127_6902606_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 3.12e-220 689.0
HKD2_k127_6902606_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000003916 203.0
HKD2_k127_6902606_2 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000004833 168.0
HKD2_k127_6902606_3 Forms part of the polypeptide exit tunnel K02926 - - 0.0000005189 53.0
HKD2_k127_6917019_0 glutathione transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001619 296.0
HKD2_k127_6917019_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 288.0
HKD2_k127_6918180_0 TonB-dependent Receptor Plug Domain K16092 - - 0.000000000000000000000000000000000000000000000000002788 205.0
HKD2_k127_6924875_0 Peptidase family M20/M25/M40 K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002876 347.0
HKD2_k127_6924875_1 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.0000000000000000000000000000000002059 143.0
HKD2_k127_6930523_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K14161 - - 0.00000000000000000000000000000000000009043 162.0
HKD2_k127_6930523_1 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.000000000000000003686 87.0
HKD2_k127_6945094_0 Amidohydrolase family K01464 - 3.5.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 411.0
HKD2_k127_6949939_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006583 511.0
HKD2_k127_6950678_0 DNA photolyase activity K03716 - 4.1.99.14 0.00000000000000000000000000000000000000000000000000000000000000000000003098 254.0
HKD2_k127_6950678_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001847 248.0
HKD2_k127_6950678_2 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000008843 53.0
HKD2_k127_6950678_3 ParB domain protein nuclease K03497 - - 0.000001617 57.0
HKD2_k127_6958332_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000001601 233.0
HKD2_k127_6958332_1 pyridoxamine 5'-phosphate K07005 - - 0.000000000000000000000000000000000000000000000000002015 197.0
HKD2_k127_6958332_2 - - - - 0.0000000002855 64.0
HKD2_k127_6966628_0 Belongs to the ClpA ClpB family K03694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 487.0
HKD2_k127_6987568_0 Protein of unknown function (DUF541) - - - 0.00000000000000000000000000000000000000000004548 169.0
HKD2_k127_7001600_0 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 336.0
HKD2_k127_7001600_1 competence protein - - - 0.00000000000000000000000000000000000000002009 161.0
HKD2_k127_7033499_0 MMPL family K07003 - - 0.0000000000000000000000000000000000000000003239 168.0
HKD2_k127_7033499_1 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000004165 152.0
HKD2_k127_7033499_2 Photosynthesis system II assembly factor YCF48 - - - 0.00000000000000000000000000003404 129.0
HKD2_k127_7033499_3 Polysaccharide deacetylase K22278 - 3.5.1.104 0.00001102 52.0
HKD2_k127_7037421_0 cytochrome p450 K05525 - 1.14.13.151 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009774 586.0
HKD2_k127_7037421_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000001306 199.0
HKD2_k127_7037421_2 COG0491 Zn-dependent hydrolases, including glyoxylases K17837 - 3.5.2.6 0.00000000000000000004097 91.0
HKD2_k127_7055833_0 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000007772 233.0
HKD2_k127_7055833_1 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.0000000000000000000000000000000000004604 149.0
HKD2_k127_7055833_2 - - - - 0.000000000791 66.0
HKD2_k127_7065750_0 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000096 368.0
HKD2_k127_7065750_1 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000001375 53.0
HKD2_k127_7128914_0 short-chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006177 283.0
HKD2_k127_7128914_1 S4 RNA-binding domain K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000006578 243.0
HKD2_k127_7128914_2 translation initiation factor activity K12065,K13671 - - 0.00000000000000796 87.0
HKD2_k127_7130613_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000001447 184.0
HKD2_k127_7154540_0 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000003484 228.0
HKD2_k127_7154540_1 Parallel beta-helix repeats - - - 0.0000000000000000000000000011 115.0
HKD2_k127_7154620_0 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000934 195.0
HKD2_k127_7154620_1 Belongs to the RtcB family K14415 - 6.5.1.3 0.0002425 44.0
HKD2_k127_7166281_0 alpha, beta - - - 0.000000000000000000000000000000000000000000000003308 182.0
HKD2_k127_7166281_1 TIM-barrel fold metal-dependent hydrolase - - - 0.000000000000000000000000000000000000001143 154.0
HKD2_k127_7166281_2 peptidyl-tyrosine sulfation - - - 0.000000005568 66.0
HKD2_k127_7174077_0 PAS domain K07710 - 2.7.13.3 0.0000000000000000000000000000000000000001956 166.0
HKD2_k127_7194951_0 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000002942 126.0
HKD2_k127_7195677_0 response regulator receiver - - - 0.0000000000000000000000000000000001364 139.0
HKD2_k127_7195677_1 Histidine kinase K07675 - 2.7.13.3 0.00000000000000000002517 105.0
HKD2_k127_7207414_0 ABC transporter K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005404 440.0
HKD2_k127_7232462_0 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001641 247.0
HKD2_k127_7232462_1 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000005379 206.0
HKD2_k127_7232462_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K15580 - - 0.0000000000000000000000000000000000000000000000005673 192.0
HKD2_k127_7257704_0 PFAM Pyridoxal-dependent decarboxylase - - - 0.0000000000000000000000000000000000000000000000000008649 186.0
HKD2_k127_7257704_1 response to cobalt ion - - - 0.0003717 49.0
HKD2_k127_7261007_0 COG1145 Ferredoxin - - - 0.0000000000000000000000001158 116.0
HKD2_k127_7261007_1 ATP phosphoribosyltransferase K00765 - 2.4.2.17 0.000000000000000000000008757 102.0
HKD2_k127_7261007_2 protein possibly involved in aromatic compounds catabolism - - - 0.0000000001035 67.0
HKD2_k127_7262218_0 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001354 289.0
HKD2_k127_7262218_1 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001167 276.0
HKD2_k127_7262218_2 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000008556 146.0
HKD2_k127_7262218_3 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0003912 43.0
HKD2_k127_7266795_0 Squalene-hopene cyclase C-terminal domain K01852,K06045 - 4.2.1.129,5.4.99.17,5.4.99.7 0.000000000000000000000000000000000000000000000000000000000000000000000001419 258.0
HKD2_k127_7266795_1 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000008626 176.0
HKD2_k127_7305471_0 thiolester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000005662 212.0
HKD2_k127_7305471_1 - - - - 0.00004545 51.0
HKD2_k127_73083_0 Protein conserved in bacteria - - - 0.000000000000000000000000000165 117.0
HKD2_k127_73083_1 Outer membrane efflux protein - - - 0.00000000105 69.0
HKD2_k127_7310388_0 PFAM phosphoesterase, RecJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003578 266.0
HKD2_k127_73117_0 Glutathione peroxidase K00432 - 1.11.1.9 0.0000000000000000000000000000000000000000000000000000000000000000008357 235.0
HKD2_k127_73117_1 Protein of unknown function (DUF3486) - - - 0.00000000000001262 81.0
HKD2_k127_73117_2 Yip1 domain - - - 0.0000003973 60.0
HKD2_k127_7323958_0 Alcohol dehydrogenase GroES-like domain - - - 0.00000000000000000009783 91.0
HKD2_k127_7323958_1 PA14 - - - 0.00000000003234 73.0
HKD2_k127_733050_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 9.982e-216 686.0
HKD2_k127_733050_1 - - - - 0.00000000000000000000000000002834 119.0
HKD2_k127_733050_2 Transcriptional regulator - - - 0.0000000000000000001604 92.0
HKD2_k127_733160_0 Amidohydrolase family - - - 1.61e-217 692.0
HKD2_k127_733160_1 Major Facilitator Superfamily - - - 0.00000000002168 71.0
HKD2_k127_733160_2 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000003236 61.0
HKD2_k127_733160_3 PFAM Glycosyl transferase family 2 K00720 - 2.4.1.80 0.0008741 42.0
HKD2_k127_73348_0 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 362.0
HKD2_k127_73348_1 Carbon-nitrogen hydrolase K12251 - 3.5.1.53 0.00000000000000000000000000000000000000000000000000000004821 198.0
HKD2_k127_7392923_0 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000694 557.0
HKD2_k127_7418895_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009948 390.0
HKD2_k127_7418895_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002119 265.0
HKD2_k127_7418895_2 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000000000002318 159.0
HKD2_k127_7418895_3 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000006098 122.0
HKD2_k127_7418895_4 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000285 105.0
HKD2_k127_7418895_5 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000009273 92.0
HKD2_k127_7418929_0 NADPH quinone oxidoreductase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000001732 224.0
HKD2_k127_7418929_1 NADH pyrophosphatase-like rudimentary NUDIX domain K03426 - 3.6.1.22 0.000000000000000000000000000000001698 136.0
HKD2_k127_7418929_2 enoyl-CoA hydratase isomerase K01692 - 4.2.1.17 0.0000000000000000007741 96.0
HKD2_k127_7447078_0 ABC transporter K02065 - - 0.00000000000000000000000000000000000007629 143.0
HKD2_k127_7447078_1 PFAM Mammalian cell entry related domain protein K06192 - - 0.0000000000000000000000000000000001716 147.0
HKD2_k127_7447078_2 ABC-type transport auxiliary lipoprotein component K09857 - - 0.0000000000000000000017 100.0
HKD2_k127_7458936_0 AsmA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 404.0
HKD2_k127_7458936_1 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00758 - 2.4.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 400.0
HKD2_k127_7471108_0 Electron transfer flavoprotein K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004466 312.0
HKD2_k127_7471108_1 PFAM Electron transfer flavoprotein alpha beta-subunit K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 301.0
HKD2_k127_7471108_2 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000004823 201.0
HKD2_k127_7485711_0 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006602 369.0
HKD2_k127_7485711_1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000002726 150.0
HKD2_k127_7485711_2 With ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate K03154 - - 0.0000000000002546 72.0
HKD2_k127_7492291_0 Adenosine specific kinase K09129 - - 0.000000000000000000000000000000000000000000000000000000006346 203.0
HKD2_k127_7492291_1 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000001694 179.0
HKD2_k127_7504567_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 413.0
HKD2_k127_7504567_1 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 0.0000000000000000000006792 97.0
HKD2_k127_7504567_2 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000009112 96.0
HKD2_k127_7507086_0 PFAM ABC transporter K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005699 364.0
HKD2_k127_7507086_1 (ABC) transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 328.0
HKD2_k127_7512932_0 Aldo Keto reductase K05882 - 1.1.1.91 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 484.0
HKD2_k127_7512932_1 Biotin carboxylase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 289.0
HKD2_k127_7512932_2 cytochrome p450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001016 241.0
HKD2_k127_7514370_0 F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000005498 165.0
HKD2_k127_7514370_1 SnoaL-like domain - - - 0.0000000000000000000000000000000000000007227 152.0
HKD2_k127_7520161_0 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000004977 245.0
HKD2_k127_7520161_1 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K00851,K00852,K01807 GO:0003674,GO:0003824,GO:0004751,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006014,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.7.1.12,2.7.1.15,5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000002619 219.0
HKD2_k127_7520161_2 Methylenetetrahydrofolate reductase - - - 0.0000000000000000000000000000000002672 143.0
HKD2_k127_7520161_3 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.0000000000000000000000002 113.0
HKD2_k127_7542595_0 DDE superfamily endonuclease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001708 271.0
HKD2_k127_7542595_1 Transposase DDE domain - - - 0.00000006579 54.0
HKD2_k127_7563790_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002113 239.0
HKD2_k127_7563790_1 PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein K00239,K00244,K00278 GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0022900,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803 1.3.5.1,1.3.5.4,1.4.3.16 0.0001454 46.0
HKD2_k127_7571745_0 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007548 369.0
HKD2_k127_7580954_0 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate K00366,K00381 - 1.7.7.1,1.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003068 608.0
HKD2_k127_7580954_1 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 387.0
HKD2_k127_7580954_2 TIGRFAM Rrf2 family protein - - - 0.000000000000000004397 86.0
HKD2_k127_7584587_0 coproporphyrinogen oxidase activity K02495 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 422.0
HKD2_k127_7584587_1 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000006038 167.0
HKD2_k127_7593285_1 DegT/DnrJ/EryC1/StrS aminotransferase family K13010 - 2.6.1.102 0.00000000004749 64.0
HKD2_k127_7593285_2 N-terminal half of MaoC dehydratase - - - 0.0000000265 61.0
HKD2_k127_7611028_0 FR47-like protein - - - 0.00000000000000000000000000006319 123.0
HKD2_k127_7611028_1 COG4235 Cytochrome c biogenesis factor K02200 - - 0.0001298 51.0
HKD2_k127_761814_0 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000004039 246.0
HKD2_k127_761814_1 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000002933 207.0
HKD2_k127_761814_2 kDa class II heat shock protein-like K13993 - - 0.0000000000000002308 85.0
HKD2_k127_7636718_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009183 462.0
HKD2_k127_7636718_1 'glutamate synthase K00123,K00317,K00528,K09835 - 1.17.1.9,1.18.1.2,1.19.1.1,1.5.8.1,1.5.8.2,5.2.1.13 0.00000000000000000001293 97.0
HKD2_k127_7639822_0 PFAM DSBA oxidoreductase - - - 0.0000000000000000000000000000000000001867 148.0
HKD2_k127_7639822_1 Circularly permuted ATP-grasp type 2 - - - 0.000000000000000000000000000002619 125.0
HKD2_k127_7639822_2 Nitrite and sulphite reductase 4Fe-4S domain K00366,K00392 - 1.7.7.1,1.8.7.1 0.00000006025 58.0
HKD2_k127_7639822_3 Pfam Pyridoxamine 5'-phosphate - - - 0.000006916 54.0
HKD2_k127_7639822_4 Dehydrogenase K00076 GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136 1.1.1.159 0.00001005 49.0
HKD2_k127_7647646_0 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000002035 271.0
HKD2_k127_7647646_1 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000006476 175.0
HKD2_k127_7647911_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000001263 192.0
HKD2_k127_7647911_1 PFAM Appr-1-p processing domain protein - - - 0.00000000000000000000000000000000000001067 153.0
HKD2_k127_7647911_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0000000000000000000000000000000004223 131.0
HKD2_k127_7648440_0 Involved in the catabolism of oxalate and in the adapatation to low pH via the induction of the oxalate-dependent acid tolerance response (ATR). Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 299.0
HKD2_k127_7648440_1 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.000000000000008413 81.0
HKD2_k127_7648440_2 positive regulation of growth - - - 0.0000000000006027 71.0
HKD2_k127_7652544_0 Flp pilus assembly protein ATPase CpaF K02283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001892 482.0
HKD2_k127_7652544_1 Pilus assembly protein K02282 - - 0.000000000000000002942 93.0
HKD2_k127_765337_0 MotA/TolQ/ExbB proton channel family K02556 - - 0.00000000000000000000000000000000000000000000645 174.0
HKD2_k127_765337_1 Belongs to the DapA family - - - 0.000003334 59.0
HKD2_k127_766065_0 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009966 397.0
HKD2_k127_7671556_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 444.0
HKD2_k127_7671556_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007766 333.0
HKD2_k127_7671556_2 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000000001036 131.0
HKD2_k127_7678416_0 mannose-ethanolamine phosphotransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000424 399.0
HKD2_k127_7680595_0 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000008859 150.0
HKD2_k127_7680595_1 Haem-degrading - - - 0.0000000000000000000000000000000000003516 145.0
HKD2_k127_7688975_0 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007619 333.0
HKD2_k127_7688975_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K00462 - 1.13.11.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003588 277.0
HKD2_k127_7688975_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 0.00000000000000000000000000000000000000000000000002861 186.0
HKD2_k127_7688975_3 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000007458 143.0
HKD2_k127_7688975_4 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00006681 45.0
HKD2_k127_7699965_0 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit K00499,K16319 - 1.14.12.1,1.14.15.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 435.0
HKD2_k127_7699965_1 short-chain dehydrogenase - - - 0.000000000000000000000000000000000000000000001393 168.0
HKD2_k127_7699965_2 Ring hydroxylating beta subunit - - - 0.000000000002818 69.0
HKD2_k127_7705032_0 S-acyltransferase activity K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 284.0
HKD2_k127_7705032_1 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.000000000000000001136 88.0
HKD2_k127_7708320_0 Ribonuclease E/G family K08300,K08301 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000001086 205.0
HKD2_k127_7708320_1 Luciferase-like monooxygenase K15854 - 1.14.14.3 0.0000000243 59.0
HKD2_k127_771361_0 copper-translocating P-type ATPase K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005355 290.0
HKD2_k127_771361_1 peptide deformylase activity K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.00000000000000000000000000000000000000000000000000000000002507 210.0
HKD2_k127_772035_0 Sulfotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009646 370.0
HKD2_k127_7725072_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000246 271.0
HKD2_k127_7725072_1 CoA-transferase family III K07544 - 2.8.3.15 0.000000000000000000000000000000000000000000000000004388 190.0
HKD2_k127_7725072_2 Major Facilitator - - - 0.0000203 55.0
HKD2_k127_7754340_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 420.0
HKD2_k127_7754340_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005583 297.0
HKD2_k127_7754340_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000001382 195.0
HKD2_k127_7756144_0 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 459.0
HKD2_k127_7756144_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 351.0
HKD2_k127_7756144_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000001126 241.0
HKD2_k127_7756144_3 PFAM Cytochrome c assembly protein - - - 0.00000000000000000000000000000000000000000000000000000008866 205.0
HKD2_k127_7756144_4 Sirohaem biosynthesis protein central K02304 - 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000008498 147.0
HKD2_k127_7756144_5 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000003019 67.0
HKD2_k127_7781377_0 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane K00247 - - 0.000000000928 64.0
HKD2_k127_7781377_1 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane K00246 - - 0.00000004143 59.0
HKD2_k127_778387_0 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 490.0
HKD2_k127_778387_1 Domain of unknown function (DUF4410) - - - 0.00000000000000000000000000000000000000000000000000000000001737 213.0
HKD2_k127_7796712_0 Deoxynucleoside kinase - - - 0.0000000000000000000000000002478 117.0
HKD2_k127_7796712_1 N-terminal half of MaoC dehydratase - - - 0.000000000000000000000000325 109.0
HKD2_k127_7796712_2 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000006841 110.0
HKD2_k127_7796712_3 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000000003122 96.0
HKD2_k127_7812232_0 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 1.718e-224 703.0
HKD2_k127_7812232_1 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000003555 176.0
HKD2_k127_7819892_0 beta-keto acid cleavage enzyme - - - 0.00000000000000000000000000000000000000000000000001761 190.0
HKD2_k127_7819892_1 - - - - 0.0000000009533 63.0
HKD2_k127_782905_0 Belongs to the GST superfamily K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 314.0
HKD2_k127_783037_0 TIM-barrel fold metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000000000004931 181.0
HKD2_k127_7839735_0 Histidine kinase K07711 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005458 293.0
HKD2_k127_7839735_1 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000002218 182.0
HKD2_k127_7839735_2 cheY-homologous receiver domain K11443 - - 0.00000001996 57.0
HKD2_k127_7840585_0 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000278 259.0
HKD2_k127_7840585_1 cytochrome p450 - - - 0.00000000000000000000000000000000000000000000000000002234 190.0
HKD2_k127_7840585_2 - - - - 0.000000000000000000000000000004756 127.0
HKD2_k127_7840585_3 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000001995 111.0
HKD2_k127_7840585_4 Mycolic acid cyclopropane synthetase - - - 0.000000000000001172 87.0
HKD2_k127_7851417_0 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000003658 159.0
HKD2_k127_7851417_1 Methylmuconolactone methyl-isomerase - - - 0.000000000000000000000000000000002736 139.0
HKD2_k127_7851417_2 Psort location CytoplasmicMembrane, score 9.46 - - - 0.0000000007308 70.0
HKD2_k127_7851417_3 Luciferase-like monooxygenase - - - 0.000001894 53.0
HKD2_k127_7851417_4 Psort location CytoplasmicMembrane, score - - - 0.000443 52.0
HKD2_k127_786207_0 Insulinase (Peptidase family M16) - - - 0.00000006117 57.0
HKD2_k127_7884157_0 similarity to GP 17427840 K07497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 417.0
HKD2_k127_7884157_1 Homeodomain-like domain - - - 0.00000000000000000000000000000001402 128.0
HKD2_k127_7886980_0 phosphatase K01104 - 3.1.3.48 0.000000000000000000000000005006 120.0
HKD2_k127_7886980_1 Copper amine oxidase, enzyme domain K00276 - 1.4.3.21 0.0000002606 56.0
HKD2_k127_7889790_0 Uncharacterized protein conserved in bacteria (DUF2330) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 495.0
HKD2_k127_7889790_1 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 383.0
HKD2_k127_7889790_2 Alcohol dehydrogenase GroES-like domain K00001,K00008 - 1.1.1.1,1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001023 276.0
HKD2_k127_7921419_0 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 388.0
HKD2_k127_7921419_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000001026 120.0
HKD2_k127_7921419_2 - - - - 0.00000000000000000000003644 100.0
HKD2_k127_7926771_0 Protein of unknown function (DUF1016) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 446.0
HKD2_k127_7928907_0 PFAM multicopper oxidase type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003016 280.0
HKD2_k127_7928907_1 Flavoprotein involved in K transport K03379 GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0055114 1.14.13.22 0.0000000000000266 73.0
HKD2_k127_7964905_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000005183 195.0
HKD2_k127_7964905_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000005705 95.0
HKD2_k127_7971885_0 Cys/Met metabolism PLP-dependent enzyme K01739,K01760,K01761 - 2.5.1.48,4.4.1.11,4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 533.0
HKD2_k127_7971885_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002443 321.0
HKD2_k127_7971885_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.0000000000000000000000000000000000000000009191 162.0
HKD2_k127_7971885_3 Hpt domain - - - 0.0000000000002614 74.0
HKD2_k127_798117_0 Lysin motif K08307 - - 0.000000000000000000000000000000000000000000000000000000000000007853 229.0
HKD2_k127_798117_1 Glutathione S-transferase, C-terminal domain - - - 0.00003223 51.0
HKD2_k127_7988633_0 PEP-utilising enzyme, N-terminal K08484 - 2.7.3.9 0.0000000000000000000000000000000000000002233 154.0
HKD2_k127_7988633_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000003214 96.0
HKD2_k127_7997458_0 PFAM Band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006038 314.0
HKD2_k127_7997458_1 NfeD-like C-terminal, partner-binding K07403 - - 0.000000000000000000000006339 106.0
HKD2_k127_8001854_0 ABC transporter transmembrane region K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002811 265.0
HKD2_k127_8001854_1 ABC transporter transmembrane region K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002696 252.0
HKD2_k127_8015667_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000001827 267.0
HKD2_k127_8015667_1 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000005135 236.0
HKD2_k127_8025301_0 Iron-sulfur cluster assembly protein K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 314.0
HKD2_k127_8025301_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - - 0.0000000000000000000000000000000000006097 143.0
HKD2_k127_8025301_2 Selenocysteine lyase K04127,K11325 - 5.1.1.17 0.000000000000000000000000001381 126.0
HKD2_k127_8025301_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000001003 80.0
HKD2_k127_8025301_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000291 61.0
HKD2_k127_8025301_5 amine dehydrogenase activity - - - 0.0000004293 59.0
HKD2_k127_8033889_0 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 292.0
HKD2_k127_8033889_1 efflux transmembrane transporter activity K02004 - - 0.00000000000000000000000000000000000000000000000001417 194.0
HKD2_k127_8033889_2 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0000000000000000000000000000000005277 134.0
HKD2_k127_8048829_0 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.00000000000000000000000000000000000000000000000000000000000009029 218.0
HKD2_k127_8048829_1 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000002413 202.0
HKD2_k127_8048829_2 Binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000003099 162.0
HKD2_k127_8048829_3 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.000000000000000000000000000000001503 132.0
HKD2_k127_8048829_4 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000002364 70.0
HKD2_k127_8048829_5 Ribosomal protein L30 K02907 - - 0.00000000002466 66.0
HKD2_k127_8063303_0 lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000000000000000000007655 110.0
HKD2_k127_8063303_1 PFAM CAAX amino terminal protease family K07052 - - 0.00003546 55.0
HKD2_k127_806481_0 CoA-transferase family III K07543 - 2.8.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000001312 273.0
HKD2_k127_806481_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000002416 239.0
HKD2_k127_806481_2 Yip1 domain - - - 0.00000000000001548 82.0
HKD2_k127_8066272_0 Flavin-binding monooxygenase-like K03379,K21730 - 1.14.13.160,1.14.13.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003222 474.0
HKD2_k127_8070647_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 1.116e-221 699.0
HKD2_k127_807483_0 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000001495 196.0
HKD2_k127_807483_1 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000008245 126.0
HKD2_k127_807483_2 associated with various cellular activities K03924 - - 0.0000000000000000000000000005076 119.0
HKD2_k127_8086939_0 Enoyl-CoA hydratase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000003999 182.0
HKD2_k127_8086939_1 PFAM conserved K06966 - 3.2.2.10 0.0000000000000000000000000000000000000008032 155.0
HKD2_k127_8086939_2 HAD-hyrolase-like K01560,K07025,K08723 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008655,GO:0009058,GO:0009112,GO:0009410,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019856,GO:0019859,GO:0030145,GO:0034641,GO:0034654,GO:0042221,GO:0042578,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.3.5,3.8.1.2 0.00000000000000001415 92.0
HKD2_k127_8103841_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000003406 233.0
HKD2_k127_8103841_1 Belongs to the GST superfamily K00799 - 2.5.1.18 0.0000000000000000000000000000000000000003821 151.0
HKD2_k127_8122736_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 6.598e-218 696.0
HKD2_k127_8126913_0 cellulose binding - - - 0.00000000000000000000000000000000000000008722 164.0
HKD2_k127_8126913_1 It is involved in the biological process described with transmembrane transport K08193,K12301 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0044425,GO:0051179,GO:0051234,GO:0055085 - 0.00000000000000004441 83.0
HKD2_k127_8143608_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 373.0
HKD2_k127_8143608_1 Metallo-beta-lactamase superfamily K13075 - 3.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000002485 269.0
HKD2_k127_8143608_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003858 270.0
HKD2_k127_8143608_3 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000001941 202.0
HKD2_k127_8149030_0 PFAM acyl-CoA dehydrogenase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 373.0
HKD2_k127_8149030_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000002348 150.0
HKD2_k127_8158512_0 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003761 492.0
HKD2_k127_8158512_1 Flavoprotein involved in K transport K03379,K21730 - 1.14.13.160,1.14.13.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 355.0
HKD2_k127_815893_0 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 366.0
HKD2_k127_8164922_0 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009254 417.0
HKD2_k127_8164922_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000006473 224.0
HKD2_k127_8164922_2 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000007051 164.0
HKD2_k127_8164922_3 - - - - 0.00000000000000000000009556 104.0
HKD2_k127_8164922_4 - - - - 0.000000000000000001158 95.0
HKD2_k127_8176650_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002044 222.0
HKD2_k127_8176650_1 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000005282 231.0
HKD2_k127_8176650_2 stress protein (general stress protein 26) - - - 0.0000000000000000000000000000000000001118 149.0
HKD2_k127_8176650_3 COG0183 Acetyl-CoA acetyltransferase - - - 0.0000000000000000000000000000000000001411 147.0
HKD2_k127_8176650_4 Haem-degrading - - - 0.0000000000000000000000000000006781 126.0
HKD2_k127_8185898_0 PFAM ABC transporter, transmembrane region K06147,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006007 425.0
HKD2_k127_8200304_0 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000004011 160.0
HKD2_k127_8200304_1 Protein of unknown function (DUF971) - - - 0.0000000001607 66.0
HKD2_k127_8208206_0 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001193 297.0
HKD2_k127_8208206_1 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000001522 86.0
HKD2_k127_8208206_2 - - - - 0.0000000008232 67.0
HKD2_k127_8266715_0 DAHP synthetase I family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007509 420.0
HKD2_k127_8293180_0 Acyl-CoA dehydrogenase, C-terminal domain K00248,K14448 - 1.3.8.1,1.3.8.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 529.0
HKD2_k127_8293180_1 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000006059 216.0
HKD2_k127_8293180_2 dehydratase - - - 0.00000000000000000000000000000000000000000000000002049 194.0
HKD2_k127_830056_0 PFAM asparagine synthase K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 289.0
HKD2_k127_830056_1 CarD-like/TRCF domain K07736 - - 0.00000000000000000000000000000000000000000000000005346 184.0
HKD2_k127_830056_2 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.00000000000000000000000000000000000000000002715 170.0
HKD2_k127_830056_3 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.000000000000000004582 85.0
HKD2_k127_8315261_0 Glucodextranase, domain N K01178 - 3.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 535.0
HKD2_k127_831739_0 tRNA synthetases class I (K) K01870 - 6.1.1.5 3.842e-212 677.0
HKD2_k127_8319931_0 Major facilitator Superfamily K08369 - - 0.00000000000000000000000000000000000000000000000000000000001278 221.0
HKD2_k127_8319931_1 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000002311 110.0
HKD2_k127_8328223_0 ABC transporter transmembrane region K18890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 356.0
HKD2_k127_8328223_1 Putative aminopeptidase - - - 0.00000000000000000002871 95.0
HKD2_k127_8328223_2 Enoyl-(Acyl carrier protein) reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.00000003141 65.0
HKD2_k127_8331259_0 Putative cyclase - - - 0.0000000000000000000000000000000000000002179 157.0
HKD2_k127_8334042_0 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 363.0
HKD2_k127_8334042_1 Haemolytic K08998 - - 0.00000000000000000002514 96.0
HKD2_k127_8334042_2 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000001373 71.0
HKD2_k127_8334042_3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000008372 63.0
HKD2_k127_8336575_0 TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain K02032,K10823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 320.0
HKD2_k127_8336575_1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000001008 154.0
HKD2_k127_8336575_2 ABC1 family K03688 - - 0.00000000000000000000000000000000000002552 159.0
HKD2_k127_8336575_3 Polymer-forming cytoskeletal - - - 0.00000000000005207 78.0
HKD2_k127_8337066_0 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000000000000007894 201.0
HKD2_k127_8337066_1 dehydratase - - - 0.00000000000000000000000000000000000000000000002286 181.0
HKD2_k127_834587_0 PFAM Transposase IS200 like - - - 0.0000000000000000000000000000003174 131.0
HKD2_k127_834587_1 Cupin 2, conserved barrel domain protein - - - 0.00006204 50.0
HKD2_k127_8348902_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000004539 198.0
HKD2_k127_8357670_0 acyl-CoA dehydrogenase K00249 - 1.3.8.7 1.469e-194 615.0
HKD2_k127_8357670_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009442 311.0
HKD2_k127_8357670_2 Short-chain dehydrogenase reductase sdr K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000001431 269.0
HKD2_k127_8357670_3 maleylacetoacetate isomerase K01801 - 5.2.1.4 0.000000000000000000000000000000000000000000000000000000000001482 217.0
HKD2_k127_8357670_4 PFAM aminoglycoside phosphotransferase K04343 - 2.7.1.72 0.000000000000000000000000000000000000000000000000000003395 203.0
HKD2_k127_8357670_5 PIN domain - - - 0.00000000000000000000000000000000001623 139.0
HKD2_k127_8357670_6 Antitoxin component of a toxin-antitoxin (TA) module - - - 0.000000000000000000000000003124 112.0
HKD2_k127_8361446_0 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000001212 247.0
HKD2_k127_8361446_1 - K03571 - - 0.0001577 50.0
HKD2_k127_8368559_0 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 361.0
HKD2_k127_8368559_1 thiolester hydrolase activity K06889 - - 0.0007 43.0
HKD2_k127_838804_0 PFAM Peptidase M16 inactive domain K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005317 271.0
HKD2_k127_8405610_0 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007263 293.0
HKD2_k127_8405610_1 Belongs to the TrpC family K01609,K13498 GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000003042 229.0
HKD2_k127_8405610_2 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000002673 85.0
HKD2_k127_8406746_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 457.0
HKD2_k127_8406746_1 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 343.0
HKD2_k127_8406746_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000007854 213.0
HKD2_k127_8416639_0 ribosomal RNA methyltransferase RrmJ FtsJ K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000007528 253.0
HKD2_k127_8416639_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000009695 256.0
HKD2_k127_8416639_2 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor - - - 0.0000000000000000000003731 103.0
HKD2_k127_8416639_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.0000000005256 64.0
HKD2_k127_8425226_0 tyrosine recombinase XerC K04763 - - 0.00000000000000000000000000000000000006205 148.0
HKD2_k127_8425226_1 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000007325 99.0
HKD2_k127_8441360_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000002698 181.0
HKD2_k127_8444992_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007375 604.0
HKD2_k127_8444992_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002016 273.0
HKD2_k127_8445214_0 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000008206 211.0
HKD2_k127_8445214_1 AAA domain K07028 - - 0.00000000000000001564 84.0
HKD2_k127_8445214_2 Sugar (and other) transporter K03446 - - 0.0000008969 51.0
HKD2_k127_8454758_0 Maf-like protein K06287 - - 0.000000000000000000000000000000000000007809 151.0
HKD2_k127_8454758_1 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.0000000000000000008461 91.0
HKD2_k127_8454758_2 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0002292 53.0
HKD2_k127_8472912_0 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 305.0
HKD2_k127_8472912_1 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.00000002043 58.0
HKD2_k127_8473096_0 MIR domain K00728 GO:0000030,GO:0000032,GO:0003674,GO:0003824,GO:0004169,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0005886,GO:0006056,GO:0006057,GO:0006464,GO:0006486,GO:0006493,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009268,GO:0009405,GO:0009628,GO:0009892,GO:0009966,GO:0009987,GO:0010033,GO:0010243,GO:0010498,GO:0010605,GO:0010646,GO:0012505,GO:0016020,GO:0016021,GO:0016043,GO:0016740,GO:0016757,GO:0016758,GO:0019222,GO:0019538,GO:0023051,GO:0030162,GO:0030163,GO:0030447,GO:0031224,GO:0031323,GO:0031324,GO:0031501,GO:0031502,GO:0031505,GO:0031506,GO:0031984,GO:0032268,GO:0032269,GO:0032991,GO:0033554,GO:0034645,GO:0034976,GO:0035268,GO:0035269,GO:0035690,GO:0035966,GO:0035967,GO:0036176,GO:0036177,GO:0036178,GO:0036211,GO:0036244,GO:0036503,GO:0040007,GO:0042175,GO:0042221,GO:0042493,GO:0042546,GO:0042710,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0044010,GO:0044011,GO:0044036,GO:0044038,GO:0044085,GO:0044182,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0044764,GO:0045229,GO:0045861,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051603,GO:0051703,GO:0051704,GO:0051716,GO:0051788,GO:0060255,GO:0065007,GO:0070085,GO:0070589,GO:0070887,GO:0071214,GO:0071218,GO:0071310,GO:0071467,GO:0071554,GO:0071555,GO:0071704,GO:0071712,GO:0071840,GO:0071852,GO:0071944,GO:0080090,GO:0080134,GO:0080135,GO:0090605,GO:0090609,GO:0097502,GO:0097582,GO:0097586,GO:0098796,GO:0098827,GO:0104004,GO:1900101,GO:1901135,GO:1901137,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901698,GO:1902494,GO:1905897,GO:1990234 2.4.1.109 0.000000000000002053 90.0
HKD2_k127_8473096_1 integral membrane protein K00728 - 2.4.1.109 0.000000000005169 79.0
HKD2_k127_8485981_0 Formamidopyrimidine-DNA glycosylase H2TH domain K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000003269 165.0
HKD2_k127_8485981_1 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000001696 163.0
HKD2_k127_8489131_0 ATP-dependent helicase deoxyribonuclease subunit B K16899 - 3.6.4.12 0.00000001971 66.0
HKD2_k127_852171_0 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001134 243.0
HKD2_k127_8530120_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000003497 233.0
HKD2_k127_8530120_1 SnoaL-like domain - - - 0.0002416 44.0
HKD2_k127_8532402_0 Belongs to the radical SAM superfamily. PqqE family K06139 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007359 321.0
HKD2_k127_8532402_1 Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ K06137 - 1.3.3.11 0.000000000000000000000000000000000000000000000000000000000000000002652 228.0
HKD2_k127_8532402_2 With PqqC converts a biosynthetic intermediate to pyrroloquinoline quinone K06138 - - 0.0000000000000000000006816 100.0
HKD2_k127_8535894_0 Transcriptional regulatory protein, C terminal K07659 - - 0.00000000000000000000000000000000000000000000000000000000000009085 223.0
HKD2_k127_8535894_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000005946 119.0
HKD2_k127_8551320_0 Amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002794 239.0
HKD2_k127_8551320_1 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.0000000000000000000000000000000000000000000001093 170.0
HKD2_k127_8552085_0 Sigma-54 interaction domain K07714,K07715 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006577 569.0
HKD2_k127_8570112_0 PQQ-like domain - - - 0.000000000000000000000000000000000000000000000001004 186.0
HKD2_k127_8570112_1 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.0000000000000001119 84.0
HKD2_k127_8577845_0 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 498.0
HKD2_k127_8577845_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005436 415.0
HKD2_k127_8577845_2 Toxic component of a toxin-antitoxin (TA) module K07171 - - 0.00000000000000000000000000000000000000000000007693 171.0
HKD2_k127_8589383_0 COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit K01768,K07315 - 3.1.3.3,4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002808 530.0
HKD2_k127_8606234_0 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 356.0
HKD2_k127_8606234_1 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000005113 226.0
HKD2_k127_860979_0 - - - - 0.000000000000000000000000000000000000006939 149.0
HKD2_k127_860979_1 - - - - 0.000000000000000002806 87.0
HKD2_k127_860979_2 - - - - 0.00000000008068 69.0
HKD2_k127_860979_3 Domain of unknown function (DUF4142) - - - 0.00001748 50.0
HKD2_k127_8631437_0 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.0000000208 64.0
HKD2_k127_8639601_0 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009237 281.0
HKD2_k127_8639601_1 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000002374 162.0
HKD2_k127_8639601_2 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000008899 95.0
HKD2_k127_8640280_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 554.0
HKD2_k127_8640280_1 von Willebrand factor (vWF) type A domain K07114 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000624 184.0
HKD2_k127_8640280_2 Bis-adenosyl-polyphosphate hydrolase, FHIT domain-containing K19710 - 2.7.7.53 0.00000000000000000000000000000000000001868 148.0
HKD2_k127_8670283_0 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 323.0
HKD2_k127_8670283_1 metallo-beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000008426 223.0
HKD2_k127_8670283_2 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000002571 151.0
HKD2_k127_8681099_0 Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 346.0
HKD2_k127_8681099_1 Uncharacterised protein family UPF0052 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004954 287.0
HKD2_k127_8681099_2 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000004909 225.0
HKD2_k127_8681099_3 NUDIX domain - - - 0.00000000000000000000000006321 113.0
HKD2_k127_8681099_4 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000001412 73.0
HKD2_k127_8705360_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008427 316.0
HKD2_k127_8705360_1 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.00000000000000000000000000000000000000000000000000000000000000000002362 239.0
HKD2_k127_8705360_2 TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000008703 195.0
HKD2_k127_8751045_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000006356 207.0
HKD2_k127_8751045_1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000001979 131.0
HKD2_k127_8765991_0 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000113 116.0
HKD2_k127_8765991_1 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000000686 66.0
HKD2_k127_8783082_0 Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - 0.00000000000000000000000000000000000000000003927 169.0
HKD2_k127_8783082_1 PFAM Helix-turn-helix type 11 domain protein - - - 0.000000000000000000000000000000000000000007262 158.0
HKD2_k127_8787370_0 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 310.0
HKD2_k127_8787370_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000000000000001765 172.0
HKD2_k127_8795259_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009405 266.0
HKD2_k127_8795259_1 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008959 246.0
HKD2_k127_8795259_2 response regulator, receiver K07658 - - 0.000000000000000002917 87.0
HKD2_k127_8800325_0 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000375 142.0
HKD2_k127_8809124_0 CBS domain K04767 - - 0.0000000000000000005461 97.0
HKD2_k127_8809124_1 CBS domain K04767 - - 0.000000000000000003785 89.0
HKD2_k127_8809124_2 PFAM UspA domain protein K06149 - - 0.000000000000000004552 94.0
HKD2_k127_8809124_3 acetyl-CoA hydrolase K01067,K18288 - 3.1.2.1 0.00000000008804 64.0
HKD2_k127_8858910_0 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 556.0
HKD2_k127_8858910_1 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 326.0
HKD2_k127_8868540_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 390.0
HKD2_k127_8868540_1 proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000002198 244.0
HKD2_k127_8869265_0 COG0477 Permeases of the major facilitator superfamily K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 505.0
HKD2_k127_8869265_1 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 320.0
HKD2_k127_8869265_2 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001389 242.0
HKD2_k127_8869265_3 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0009976 49.0
HKD2_k127_8869687_0 Flavin-binding monooxygenase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006917 423.0
HKD2_k127_8869687_1 CobW/HypB/UreG, nucleotide-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 327.0
HKD2_k127_8869687_2 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001887 262.0
HKD2_k127_8872609_0 Psort location CytoplasmicMembrane, score - - - 0.000000005429 67.0
HKD2_k127_8876136_0 Belongs to the UPF0145 family - - - 0.0000000000000000000000000000000000000006069 152.0
HKD2_k127_8876136_1 hydrolase activity, acting on ester bonds - - - 0.0000000000000000000000000000000000002105 149.0
HKD2_k127_8876136_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K19548 - 1.1.1.385 0.0000000000000001156 85.0
HKD2_k127_8882722_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 301.0
HKD2_k127_8882722_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.00000000000000000001793 96.0
HKD2_k127_8883675_0 oxidoreductases (related to aryl-alcohol - - - 0.0000000000000000000000000000000000000000000000006394 183.0
HKD2_k127_8883675_1 Amidohydrolase - - - 0.000000005899 65.0
HKD2_k127_8887236_0 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000000000000000000000000000000000000000000465 196.0
HKD2_k127_8887236_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000001608 145.0
HKD2_k127_8906597_0 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 342.0
HKD2_k127_8906597_1 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000003253 92.0
HKD2_k127_8912675_0 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000001228 258.0
HKD2_k127_8912675_1 Peptidase family M28 - - - 0.0000000000000000007644 92.0
HKD2_k127_8913842_0 COG1042 Acyl-CoA synthetase (NDP forming) - - - 0.0000000000005978 78.0
HKD2_k127_8913842_1 DNA methylase K07316 - 2.1.1.72 0.000000000008959 68.0
HKD2_k127_8922621_0 L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000000000000000000000000000000000000000000000000000000002654 211.0
HKD2_k127_8922621_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000001318 97.0
HKD2_k127_8922621_2 Luciferase-like monooxygenase - - - 0.00000000000001544 79.0
HKD2_k127_8932229_0 Protein of unknown function (DUF1254) - - - 0.00000000000000000000000000000000000000000000000000000002975 200.0
HKD2_k127_8932229_1 phosphatase activity K07025 - - 0.00000005602 57.0
HKD2_k127_8949150_0 ADP-glyceromanno-heptose 6-epimerase activity K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000001201 260.0
HKD2_k127_8949150_1 Carotenoid biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000005007 211.0
HKD2_k127_8952822_0 dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000001676 198.0
HKD2_k127_8955452_0 4-coumarate--CoA ligase-like K22133 GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005911,GO:0006082,GO:0006950,GO:0006952,GO:0007275,GO:0008150,GO:0008152,GO:0009056,GO:0009506,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009605,GO:0009607,GO:0009620,GO:0009719,GO:0009725,GO:0009735,GO:0009791,GO:0009987,GO:0010029,GO:0010030,GO:0010033,GO:0010035,GO:0010038,GO:0010154,GO:0010214,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0022414,GO:0030054,GO:0032501,GO:0032502,GO:0033609,GO:0033611,GO:0042221,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046686,GO:0048046,GO:0048316,GO:0048518,GO:0048580,GO:0048582,GO:0048608,GO:0048731,GO:0048856,GO:0050203,GO:0050789,GO:0050793,GO:0050832,GO:0050896,GO:0051094,GO:0051239,GO:0051240,GO:0051704,GO:0051707,GO:0055044,GO:0061458,GO:0065007,GO:0071704,GO:0098542,GO:1900140,GO:1901575,GO:2000026 6.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009113 393.0
HKD2_k127_8955452_1 Protein of unknown function (DUF3309) - - - 0.0000000000000000009532 86.0
HKD2_k127_8965629_0 response regulator K10943 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001131 266.0
HKD2_k127_8965629_1 Histidine kinase - - - 0.0000000000004776 71.0
HKD2_k127_8970272_0 L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000006275 211.0
HKD2_k127_8971706_0 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004064 273.0
HKD2_k127_8971706_1 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.000000000000000000000000000000000003192 139.0
HKD2_k127_8971706_2 SNARE associated Golgi protein - - - 0.000000000000000000000000000003234 127.0
HKD2_k127_8978522_0 Male sterility protein K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 293.0
HKD2_k127_8982220_0 transferase activity, transferring glycosyl groups K00713,K03280 - 2.4.1.56 0.0000000000000000000000000000000000000000000000000000000000000000007922 241.0
HKD2_k127_8998510_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000002211 249.0
HKD2_k127_8998510_1 COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - 0.00000000000000000000000000000000000000000007959 162.0
HKD2_k127_8998510_2 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 0.00000000000000000000000000000000000004538 144.0
HKD2_k127_9013179_0 amino acid-binding ACT domain protein K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 422.0
HKD2_k127_9013179_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0016829,GO:0016835,GO:0016838,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000002548 245.0
HKD2_k127_9013179_2 aminotransferase K14261 - - 0.0000000003237 61.0
HKD2_k127_9020809_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 2.614e-225 708.0
HKD2_k127_9020809_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005522 270.0
HKD2_k127_9020809_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000001702 228.0
HKD2_k127_9020809_3 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000008807 61.0
HKD2_k127_9023713_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 443.0
HKD2_k127_9030600_0 Acyl-CoA dehydrogenase, C-terminal domain K22027 - 1.14.13.235 0.00000000000001385 85.0
HKD2_k127_9034640_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 380.0
HKD2_k127_9034640_1 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.000000000000000000000000000000000000000000000004188 179.0
HKD2_k127_9046592_0 Dehydrogenase K15371 - 1.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000234 454.0
HKD2_k127_9049622_0 Peptidogalycan biosysnthesis/recognition K09919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002598 320.0
HKD2_k127_9049622_1 C-terminal, D2-small domain, of ClpB protein K03694 - - 0.000000000000000000000000000000000002713 144.0
HKD2_k127_9049622_2 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000001971 132.0
HKD2_k127_9050043_0 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008609 327.0
HKD2_k127_9054968_0 PFAM peptidase S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 388.0
HKD2_k127_9056772_0 NnrS protein K07234 - - 0.0000000000000000000000000000000000000000000000000000002064 199.0
HKD2_k127_9057167_0 Biotin carboxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007719 445.0
HKD2_k127_9057167_1 addiction module antidote protein, CC2985 family - - - 0.00000007736 54.0
HKD2_k127_907667_0 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K00018 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.1.1.26,1.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 326.0
HKD2_k127_907667_1 Histidine biosynthesis protein K01814,K01817 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16,5.3.1.24 0.0006524 42.0
HKD2_k127_9084176_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004642 275.0
HKD2_k127_9084176_1 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000000000002392 171.0
HKD2_k127_9084176_2 Right handed beta helix region - - - 0.0000003356 60.0
HKD2_k127_9084845_0 C-terminus of AA_permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008085 408.0
HKD2_k127_9095975_0 - - - - 0.0000000000000000000000000000002589 129.0
HKD2_k127_9095975_1 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00002824 51.0
HKD2_k127_9099600_0 TIGRFAM formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 2.356e-214 671.0
HKD2_k127_9099600_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000001181 85.0
HKD2_k127_9099600_2 NADH-dependant formate dehydrogenase delta subunit FdsD K00126 - 1.17.1.9 0.0000000000000001699 81.0
HKD2_k127_910754_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009648 515.0
HKD2_k127_910754_1 - - - - 0.000000000000005219 82.0
HKD2_k127_9115054_0 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000172 243.0
HKD2_k127_9115054_1 glycosyl transferase K20534 - - 0.000000000000002474 76.0
HKD2_k127_9115054_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000007425 68.0
HKD2_k127_9125460_0 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000001628 231.0
HKD2_k127_9125460_1 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000000000000000000000000000004469 151.0
HKD2_k127_9129768_0 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002671 275.0
HKD2_k127_9129768_1 Alpha beta hydrolase - - - 0.00000000001003 68.0
HKD2_k127_9145670_0 Glycosyl transferase family 4 K02851 - 2.7.8.33,2.7.8.35 0.00000000000000000000000000000000000000000000000000004037 208.0
HKD2_k127_9145670_1 - - - - 0.000001204 51.0
HKD2_k127_9148180_0 Dehydrogenase K17760 - 1.1.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 301.0
HKD2_k127_9148180_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000004298 128.0
HKD2_k127_9148180_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000003939 72.0
HKD2_k127_915344_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599,K01719,K13542 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,4.1.1.37,4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 537.0
HKD2_k127_915344_1 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000003002 262.0
HKD2_k127_9179894_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 3.479e-206 644.0
HKD2_k127_9188929_0 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 9.911e-236 740.0
HKD2_k127_9188929_1 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000007636 253.0
HKD2_k127_9188929_2 Carbamoyl-phosphate synthetase large chain domain protein K01961,K01968,K11263 - 6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000008064 247.0
HKD2_k127_9188929_3 Biotin-requiring enzyme - - - 0.0000000000000000000000008817 109.0
HKD2_k127_9188929_5 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00001996 51.0
HKD2_k127_9190256_0 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 506.0
HKD2_k127_9190256_1 Steryl acetyl hydrolase - - - 0.0000000000000000000000000000000000000000003238 162.0
HKD2_k127_9190256_2 protein homotetramerization - - - 0.0000000000000000000000000000005136 130.0
HKD2_k127_9190256_3 - - - - 0.0000000007375 65.0
HKD2_k127_9195960_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000535 280.0
HKD2_k127_9195960_1 Glycosyl hydrolase 36 superfamily, catalytic domain K13688,K18786 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.321 0.00000000000000000000001309 101.0
HKD2_k127_9198183_0 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003044 383.0
HKD2_k127_9205240_0 D12 class N6 adenine-specific DNA methyltransferase K06223 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005423 345.0
HKD2_k127_9205240_1 ATPase family associated with various cellular activities (AAA) K07452 - - 0.000000000000000000000000000000000003986 141.0
HKD2_k127_9205240_2 Amino acid permease - - - 0.0000000000007907 70.0
HKD2_k127_9210628_0 Squalene/phytoene synthase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005442 262.0
HKD2_k127_9210628_1 Squalene/phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000001431 139.0
HKD2_k127_9216112_0 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006055 419.0
HKD2_k127_9216112_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000003818 194.0
HKD2_k127_9216112_2 Glycosyl transferase, family 2 K00721,K01912,K08301 - 2.4.1.83,6.2.1.30 0.00000000000000000000000000002381 133.0
HKD2_k127_9216112_3 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000000000000001275 88.0
HKD2_k127_9216112_4 DREV methyltransferase - - - 0.000000000000001634 89.0
HKD2_k127_9221031_0 Pfam Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 582.0
HKD2_k127_9221031_1 Carboxylesterase family - - - 0.0000000000000000000000000000000000000000000000000000000000000006896 222.0
HKD2_k127_9221556_0 Biotin carboxylase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 600.0
HKD2_k127_9232519_0 Resistance protein K15547 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:1901474,GO:1901682,GO:1902599 - 0.0000000000001196 83.0
HKD2_k127_9234356_0 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001987 379.0
HKD2_k127_9234356_1 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K00652,K01935 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47,6.3.3.3 0.00000000000000000000000000000004414 131.0
HKD2_k127_9263742_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058,K16843 - 1.1.1.310,1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009758 348.0
HKD2_k127_9263742_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007297 340.0
HKD2_k127_9273012_0 Phosphoenolpyruvate carboxylase K01595 - 4.1.1.31 7.556e-226 731.0
HKD2_k127_9273012_1 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000008165 177.0
HKD2_k127_9297126_0 PFAM Type II secretion system protein E K02283,K03609 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 438.0
HKD2_k127_9297126_1 PFAM Type II secretion system F K12510 - - 0.00000000000000000000000000000000000000006315 163.0
HKD2_k127_9297126_2 Type II secretion system (T2SS), protein F - - - 0.0000000000000000000000000000000000000541 157.0
HKD2_k127_9297126_3 Sigma-54 interaction domain K07714 - - 0.0000000000000000000107 97.0
HKD2_k127_9297765_0 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003,K05685 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 369.0
HKD2_k127_9317021_0 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000003638 177.0
HKD2_k127_9317021_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000001183 61.0
HKD2_k127_9317946_0 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 308.0
HKD2_k127_9317946_1 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008744 299.0
HKD2_k127_9317946_2 Uncharacterized ACR, COG1399 K07040 - - 0.00000000000000000000000000002451 123.0
HKD2_k127_9317946_3 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000000000000000000006394 106.0
HKD2_k127_9317946_4 Ribosomal L32p protein family K02911 - - 0.0000000000000001119 80.0
HKD2_k127_9317946_5 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000001287 77.0
HKD2_k127_9324251_0 Acyl-CoA dehydrogenase type 2 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 574.0
HKD2_k127_9324251_1 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005588 274.0
HKD2_k127_9324251_2 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000006911 181.0
HKD2_k127_9324251_3 COG2010 Cytochrome c, mono- and diheme variants - - - 0.0000000000000000000001407 104.0
HKD2_k127_9334286_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 8.907e-292 907.0
HKD2_k127_933845_0 Poly A polymerase head domain K00970 - 2.7.7.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 325.0
HKD2_k127_935381_0 TIGRFAM Polyphosphate nucleotide phosphotransferase, PPK2 K00937 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 382.0
HKD2_k127_935381_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000001283 184.0
HKD2_k127_935381_2 MlaD protein K06192 - - 0.000000000000000000000000000000000000000006394 166.0
HKD2_k127_935381_3 ABC-type transport auxiliary lipoprotein component K09857 - - 0.000000000000003438 84.0
HKD2_k127_9371262_0 HlyD family secretion protein K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 295.0
HKD2_k127_9371262_1 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000004603 226.0
HKD2_k127_9371262_2 Biotin-lipoyl like K02005 - - 0.0000000157 58.0
HKD2_k127_9384288_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 295.0
HKD2_k127_9384288_1 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000003243 122.0
HKD2_k127_9384288_2 TIGRFAM DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.000005453 57.0
HKD2_k127_9384288_3 Lipopolysaccharide-assembly - - - 0.000078 52.0
HKD2_k127_939172_0 SnoaL-like domain - - - 0.000000000000000000009633 98.0
HKD2_k127_939172_1 SnoaL-like domain - - - 0.0000000000004774 75.0
HKD2_k127_9404389_0 Circularly permuted ATP-grasp type 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 419.0
HKD2_k127_9404389_1 A predicted alpha-helical domain with a conserved ER motif. - - - 0.0000000003625 66.0
HKD2_k127_9413358_0 Thioredoxin-like [2Fe-2S] ferredoxin K00127 - - 0.00000000000000000000000000000000000000000000000000000423 194.0
HKD2_k127_9413358_1 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00124 - - 0.000000000000000000000003846 103.0
HKD2_k127_9413358_2 PFAM Conserved nitrate reductase-associated protein (Nitr_red_assoc) - - - 0.000000000000000002779 90.0
HKD2_k127_9413358_3 Carbohydrate kinase K00941 - 2.7.1.49,2.7.4.7 0.0007 43.0
HKD2_k127_9452441_0 PFAM secretion protein HlyD family protein K03543 - - 0.0000000000000000000000000000000000000000000000000000000000005334 222.0
HKD2_k127_9452441_1 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.00000002432 64.0
HKD2_k127_9474681_0 Iron permease FTR1 family K07243 - - 0.000000000000000000000000000000000000000006807 164.0
HKD2_k127_9474681_1 PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.00000000000001334 76.0
HKD2_k127_9484151_0 COG0657 Esterase lipase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003673 333.0
HKD2_k127_9484151_1 Luciferase-like monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 296.0
HKD2_k127_9491270_0 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006272 531.0
HKD2_k127_9491270_1 Mur ligase, middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 324.0
HKD2_k127_9491270_2 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008741 289.0
HKD2_k127_9491270_3 LD-carboxypeptidase K01297 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009050,GO:0009056,GO:0009254,GO:0009987,GO:0016787,GO:0019538,GO:0030203,GO:0034641,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.4.17.13 0.00000000000000000000000000000000000000000000000000000000000004571 227.0
HKD2_k127_9508843_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005535 576.0
HKD2_k127_9508843_1 Glucokinase K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 310.0
HKD2_k127_9508843_2 DeoC/LacD family aldolase K11645 - 4.1.2.13 0.0000000003967 63.0
HKD2_k127_9514357_0 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000002177 210.0
HKD2_k127_952556_0 RNA-binding protein homologous to eukaryotic snRNP - - - 0.000000000000000000000000000000000000000000003921 175.0
HKD2_k127_952556_1 Thioredoxin-like - - - 0.00000000000000000003402 96.0
HKD2_k127_9537246_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009346 474.0
HKD2_k127_9537246_1 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000001345 170.0
HKD2_k127_9537246_2 Belongs to the OprB family - - - 0.000000000000000000000000000000007727 132.0
HKD2_k127_9537246_3 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000528 103.0
HKD2_k127_9537246_4 KH domain K06960 - - 0.00000000000000000000002028 101.0
HKD2_k127_9537246_5 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000261 89.0
HKD2_k127_9544963_0 Peptidase family M48 - - - 0.0000000000001165 80.0
HKD2_k127_9544963_1 PFAM CBS domain containing protein K07168 - - 0.0000000000004905 70.0
HKD2_k127_9553241_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006348 418.0
HKD2_k127_9553241_1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000000000000000002278 215.0
HKD2_k127_9565043_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 306.0
HKD2_k127_9585122_0 Flavin-binding monooxygenase-like K03379 - 1.14.13.22 0.000000000000000000000000000000000000000006727 157.0
HKD2_k127_9585122_1 ABC-type transport auxiliary lipoprotein component K09857 - - 0.000000000000000000000000000000000000004335 152.0
HKD2_k127_9585122_2 PFAM Mammalian cell entry related domain protein K06192 - - 0.0000000000000003509 81.0
HKD2_k127_9604465_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787,K15726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003204 614.0
HKD2_k127_9604465_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.000000000000000000000000000000000000000000000000000000000001272 224.0
HKD2_k127_9604465_2 outer membrane efflux protein K15725 - - 0.000000001215 65.0
HKD2_k127_962034_0 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.0000000000000000000000000000000000000000000000000002942 193.0
HKD2_k127_962034_1 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000003315 85.0
HKD2_k127_9623640_0 Putative cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007237 276.0
HKD2_k127_9623640_1 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000002178 187.0
HKD2_k127_9623640_2 Chromate transporter K07240 - - 0.0000000001114 63.0
HKD2_k127_9630775_0 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005358 340.0
HKD2_k127_9630775_1 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000009871 235.0
HKD2_k127_9630775_2 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000006388 152.0
HKD2_k127_963142_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 414.0
HKD2_k127_963142_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000004828 136.0
HKD2_k127_9661147_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 3.134e-209 663.0
HKD2_k127_9661147_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004513 263.0
HKD2_k127_9662961_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 413.0
HKD2_k127_9667404_0 Uncharacterised protein family (UPF0182) K09118 - - 0.0000000000000000000000000000003959 129.0
HKD2_k127_9667404_1 Protein of unknown function (DUF1232) - - - 0.00004023 50.0
HKD2_k127_9667404_2 Protein of unknown function (DUF1109) - - - 0.0006907 48.0
HKD2_k127_9673482_0 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 309.0
HKD2_k127_9673482_1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01586 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000005959 264.0
HKD2_k127_9673482_2 Fibronectin, type III domain - - - 0.00004554 52.0
HKD2_k127_9683752_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005438 285.0
HKD2_k127_9683752_1 R3H domain protein K06346 - - 0.0000000000000000000000000002892 127.0
HKD2_k127_9691714_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 313.0
HKD2_k127_9691714_1 Belongs to the peptidase S16 family K01338,K04076,K04770 - 3.4.21.53 0.00000000000000000000000000000000000001314 148.0
HKD2_k127_9697078_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.000002693 57.0
HKD2_k127_9697078_1 belongs to the sigma-70 factor family, ECF subfamily K03088 - - 0.0005274 50.0
HKD2_k127_9702540_0 PFAM Carbamoyl-phosphate synthase L chain ATP-binding K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005634 557.0
HKD2_k127_9712060_0 ThiF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 394.0
HKD2_k127_9712060_1 Peroxiredoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000001503 143.0
HKD2_k127_9712060_2 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.0003116 44.0
HKD2_k127_9717716_0 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009625 329.0
HKD2_k127_9717716_1 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.0000000000000000000000004102 106.0
HKD2_k127_9717716_2 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00162 - 1.2.4.1 0.000000000002844 67.0
HKD2_k127_974790_0 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001676 284.0
HKD2_k127_974790_1 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.000000000000000000000000000000000000000000000000414 185.0
HKD2_k127_974790_2 elongation factor Tu domain 2 protein K02355 - - 0.0000000000000000000000000000000000000000000000007205 181.0
HKD2_k127_974790_3 cytochrome P450 K00493,K14338 - 1.14.14.1,1.6.2.4 0.00000000000667 66.0
HKD2_k127_974790_4 Iron-containing redox enzyme K06137 - 1.3.3.11 0.000005398 56.0
HKD2_k127_9748579_0 Copper amine oxidase, N2 domain K00276 - 1.4.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007954 360.0
HKD2_k127_9748579_1 Cupin 2, conserved barrel domain protein - - - 0.0000000239 55.0
HKD2_k127_9750919_0 Proline dehydrogenase K00318 - - 0.0000000000000000000000001193 111.0
HKD2_k127_9750919_1 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.000000000000000000001388 106.0
HKD2_k127_9756075_0 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000001684 263.0
HKD2_k127_9756075_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000004325 204.0
HKD2_k127_9775877_0 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000004442 197.0
HKD2_k127_9775877_1 alpha-ribazole phosphatase activity K02226,K15634,K15640 - 3.1.3.73,5.4.2.12 0.0000000000000002101 83.0
HKD2_k127_9775877_2 - catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - 0.00006219 47.0
HKD2_k127_9803637_0 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005078 302.0
HKD2_k127_9803637_1 SpoIID LytB domain protein K06381 - - 0.000000000000000000000000000000000001672 139.0
HKD2_k127_9824445_0 ATPase associated with K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000008612 225.0
HKD2_k127_9824445_1 protein some members contain a von Willebrand factor type A - - - 0.000000000000000000000000009098 114.0
HKD2_k127_982513_0 AAA domain, putative AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008026 296.0
HKD2_k127_982513_1 Belongs to the prokaryotic GSH synthase family K01920 GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003987 274.0
HKD2_k127_982513_2 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008656 263.0
HKD2_k127_982513_3 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.0000000000000000000005645 97.0
HKD2_k127_982903_0 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 344.0
HKD2_k127_982903_1 Amp-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000008246 226.0
HKD2_k127_9834140_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 531.0
HKD2_k127_9834140_1 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000002403 55.0
HKD2_k127_9852939_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000472 514.0
HKD2_k127_9852939_1 Iron-sulphur cluster assembly - - - 0.0000000000000001126 83.0
HKD2_k127_9852939_2 Belongs to the HesB IscA family K13628 - - 0.00000000000001853 73.0
HKD2_k127_9852939_3 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051604,GO:0071704,GO:0097428,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - 0.0000000002854 69.0
HKD2_k127_9856787_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 496.0
HKD2_k127_9856787_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000006571 86.0
HKD2_k127_9888472_0 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 460.0
HKD2_k127_9888472_1 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000002575 101.0
HKD2_k127_9935353_0 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005356 357.0
HKD2_k127_993958_0 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006412 371.0
HKD2_k127_9941024_0 Flagellar Motor Protein K02557 - - 0.00000000000000000000000000000000000000000003007 167.0
HKD2_k127_9941024_1 - - - - 0.0000000000242 72.0
HKD2_k127_9945764_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000004208 88.0
HKD2_k127_9946975_0 DNA replication proofreading K02336,K06877 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002739 371.0
HKD2_k127_9964230_0 PFAM Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003487 601.0
HKD2_k127_9964230_1 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.00000000000000000000000000000000000000000000000000001247 199.0
HKD2_k127_9964230_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 GO:0008150,GO:0040007 2.7.4.16 0.000000000000000000000003579 105.0
HKD2_k127_9975898_0 TIGRFAM luciferase family oxidoreductase, group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 424.0
HKD2_k127_9975898_1 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007375 274.0
HKD2_k127_9975898_2 Amidohydrolase family - - - 0.000000000000000000000000001618 112.0