logo

Overview

ID MAG01777
Name HKD2_bin.18
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Nitrospirota
Class Thermodesulfovibrionia
Order Thermodesulfovibrionales
Family UBA9159
Genus DASRZP01
Species
Assembly information
Completeness (%) 76.78
Contamination (%) 3.92
GC content (%) 52.0
N50 (bp) 9,952
Genome size (bp) 2,222,438

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2151

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10019430_0 (AIR) carboxylase K06898 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001148 267.0
HKD2_k127_10019430_1 PFAM NAD-dependent glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000008665 219.0
HKD2_k127_10019430_2 Cation efflux family K16264 - - 0.000000000000000000000000000000000001314 141.0
HKD2_k127_10065682_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 4.608e-292 907.0
HKD2_k127_10065682_1 phosphoglucosamine mutase activity K01835,K01840 - 5.4.2.2,5.4.2.8 1.348e-222 702.0
HKD2_k127_10065682_2 PFAM Glycosyl hydrolase family 3 N terminal domain K01207,K05349 - 3.2.1.21,3.2.1.52 0.000000000000000000000000000000000000000000000000000000005584 217.0
HKD2_k127_10065682_3 PFAM DnaJ homologue, subfamily C, member 28 - - - 0.000000000000000075 84.0
HKD2_k127_10065682_4 Amidohydrolase family - - - 0.000000000000001469 88.0
HKD2_k127_10065682_5 P pilus assembly Cpx signaling pathway, periplasmic inhibitor zinc-resistance associated protein K06006 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0010033,GO:0014070,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0044464,GO:0050896,GO:0051082,GO:0061077,GO:1990507 - 0.000007901 55.0
HKD2_k127_101129_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 4.31e-248 781.0
HKD2_k127_101129_1 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002452 272.0
HKD2_k127_101129_2 pfam psp1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007144 252.0
HKD2_k127_101129_3 metallopeptidase activity K03630 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008424 243.0
HKD2_k127_101129_4 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000003714 188.0
HKD2_k127_101129_5 - - - - 0.000000000000000007538 86.0
HKD2_k127_1042439_0 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852,K00856 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009935 459.0
HKD2_k127_1042439_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003278 312.0
HKD2_k127_1042439_2 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001063 286.0
HKD2_k127_1042439_3 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000001302 111.0
HKD2_k127_1042439_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000006195 97.0
HKD2_k127_108047_0 ABC transporter K06020 - 3.6.3.25 3.139e-314 970.0
HKD2_k127_108047_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003779 476.0
HKD2_k127_108047_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 428.0
HKD2_k127_108047_3 Putative MetA-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 389.0
HKD2_k127_108047_4 Cytidine and deoxycytidylate deaminase zinc-binding region K01493 - 3.5.4.12 0.000000000000000000000000000000000000000000000000000000007593 205.0
HKD2_k127_108047_5 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005515,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009161,GO:0009165,GO:0009259,GO:0009987,GO:0010181,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042726,GO:0042727,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046443,GO:0046444,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072387,GO:0072388,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.7.2 0.000000000000000000000009214 105.0
HKD2_k127_108047_6 GAF domain - - - 0.0000002615 54.0
HKD2_k127_1143119_0 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 5.245e-204 642.0
HKD2_k127_1143119_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 491.0
HKD2_k127_1143119_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 430.0
HKD2_k127_1143119_3 pfam abc K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 374.0
HKD2_k127_1143119_4 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005246 328.0
HKD2_k127_1143119_5 ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 323.0
HKD2_k127_1143119_6 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001194 259.0
HKD2_k127_1143119_7 - - - - 0.000000000000000001032 91.0
HKD2_k127_1143119_8 Malate dehydrogenase K00027 - 1.1.1.38 0.0008002 42.0
HKD2_k127_1295738_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000068 570.0
HKD2_k127_1295738_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005367 472.0
HKD2_k127_1295738_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003296 390.0
HKD2_k127_1295738_3 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000644 302.0
HKD2_k127_1295738_4 Lipoate-protein ligase K03800 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 0.0000000000000000000000000000000000000000000000254 181.0
HKD2_k127_1295738_5 DNA topoisomerase type I activity K03168 - 5.99.1.2 0.0000000000000000000000000000000000000004424 154.0
HKD2_k127_1295738_6 Belongs to the UPF0102 family K07460 - - 0.000000000000000000000000003392 114.0
HKD2_k127_1295738_7 Predicted RNA-binding protein - - - 0.00000000000002454 78.0
HKD2_k127_1295738_8 - - - - 0.00000000506 63.0
HKD2_k127_1295738_9 PFAM chemotaxis sensory transducer K03406 - - 0.0001803 47.0
HKD2_k127_132487_0 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 446.0
HKD2_k127_132487_1 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000001874 275.0
HKD2_k127_136396_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic K00058 - 1.1.1.399,1.1.1.95 3.325e-195 621.0
HKD2_k127_136396_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 523.0
HKD2_k127_136396_2 4 iron, 4 sulfur cluster binding K07139 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009487 413.0
HKD2_k127_136396_3 Evidence 2b Function of strongly homologous gene - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003435 259.0
HKD2_k127_136396_4 PFAM Phosphoribosyltransferase - - - 0.00000000000000000000000000000000000000132 157.0
HKD2_k127_136396_5 - - - - 0.000000000005034 73.0
HKD2_k127_1364018_0 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003306 563.0
HKD2_k127_1364018_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005529 473.0
HKD2_k127_1364018_2 poly(R)-hydroxyalkanoic acid synthase K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 348.0
HKD2_k127_1364018_3 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000009787 192.0
HKD2_k127_1364018_4 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.0000000000000000000000006533 117.0
HKD2_k127_1364018_5 - - - - 0.00000000000000001696 88.0
HKD2_k127_1364018_6 PFAM Mammalian cell entry related K02067 - - 0.0000001732 60.0
HKD2_k127_1364018_7 ABC-type transport auxiliary lipoprotein component K09857 - - 0.0004426 50.0
HKD2_k127_1365985_0 Alpha amylase, catalytic domain K06044 - 5.4.99.15 0.0 1204.0
HKD2_k127_1365985_1 Belongs to the glycosyl hydrolase 57 family - - - 0.0 1059.0
HKD2_k127_1365985_2 glycoside hydrolase, family 13 domain protein K01236 - 3.2.1.141 0.00000000002967 66.0
HKD2_k127_1371023_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 6.423e-240 749.0
HKD2_k127_1371023_1 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 1.753e-235 738.0
HKD2_k127_1371023_2 Molecular chaperone. Has ATPase activity K04079 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 413.0
HKD2_k127_1383723_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 591.0
HKD2_k127_1383723_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007369 580.0
HKD2_k127_1383723_2 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000001807 233.0
HKD2_k127_1383723_3 EamA-like transporter family - - - 0.0000000000005831 69.0
HKD2_k127_1409159_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003407 453.0
HKD2_k127_1409159_1 Receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009195 389.0
HKD2_k127_1409159_2 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006796 269.0
HKD2_k127_1426730_0 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004478 534.0
HKD2_k127_1426730_1 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005309 477.0
HKD2_k127_1426730_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002777 287.0
HKD2_k127_1426730_3 ferric iron binding K02380 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008199,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0051604,GO:0055114,GO:0071704,GO:1901564 - 0.000000000000000000000000000000000004487 147.0
HKD2_k127_1426730_4 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - - 0.00000000000000005955 82.0
HKD2_k127_1427955_0 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001798 552.0
HKD2_k127_1427955_1 PFAM peptidase S1 and S6 chymotrypsin Hap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 487.0
HKD2_k127_1427955_2 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000005257 218.0
HKD2_k127_1427955_3 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000004873 204.0
HKD2_k127_1427955_4 Glycine-zipper domain - - - 0.00000000000000000000000000000000000000000000000000002611 193.0
HKD2_k127_1427955_5 - - - - 0.000000000000000000000000000000001018 136.0
HKD2_k127_1427955_6 - - - - 0.0000000000000000000258 98.0
HKD2_k127_1462492_0 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004666 532.0
HKD2_k127_1462492_1 Large family of predicted nucleotide-binding domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 340.0
HKD2_k127_1462492_2 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001154 257.0
HKD2_k127_1462492_3 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000006737 202.0
HKD2_k127_1462492_4 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.00000000000000000000000000000000000000000000000000000005919 203.0
HKD2_k127_1487213_0 Iron-sulfur cluster-binding domain - - - 1.047e-214 676.0
HKD2_k127_1487213_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 2.378e-208 668.0
HKD2_k127_1487213_2 Protein of unknown function (DUF1847) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008458 381.0
HKD2_k127_1487213_3 Protein of unknown function (DUF498/DUF598) - - - 0.000000000000000000000000005082 113.0
HKD2_k127_1487213_4 PAS domain containing protein K03406,K13924,K14986 - 2.1.1.80,2.7.13.3,3.1.1.61 0.00000000000103 78.0
HKD2_k127_1500690_0 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005046 351.0
HKD2_k127_1500690_1 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000002931 144.0
HKD2_k127_1500690_2 Drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000002238 131.0
HKD2_k127_1521489_0 4Fe-4S binding domain - - - 4.181e-223 702.0
HKD2_k127_1521489_1 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 402.0
HKD2_k127_1521489_2 isochorismatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 383.0
HKD2_k127_1521489_3 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000001332 207.0
HKD2_k127_1521489_4 Catalyzes the reduction of arsenate As(V) to arsenite As(III) K03741 - 1.20.4.1 0.0000000000000000000000000000000000000000004249 162.0
HKD2_k127_1521489_5 CO dehydrogenase acetyl-CoA synthase gamma subunit (Corrinoid Fe-S protein) - - - 0.000000000000000000000000000000000003081 148.0
HKD2_k127_1521489_6 Methyltransferase K08316 - 2.1.1.171 0.000000000000000000000000000000003166 135.0
HKD2_k127_1521489_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000002674 60.0
HKD2_k127_1525248_0 AIR synthase related protein, N-terminal domain K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008979 452.0
HKD2_k127_1525248_1 Alginate export - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005707 438.0
HKD2_k127_1525248_10 PFAM DsrE DsrF-like family - - - 0.000002593 55.0
HKD2_k127_1525248_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003701 418.0
HKD2_k127_1525248_3 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 398.0
HKD2_k127_1525248_4 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005782 306.0
HKD2_k127_1525248_5 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000000000000000000005815 162.0
HKD2_k127_1525248_6 cobalamin synthesis protein, P47K - - - 0.000000000000000000000000000000000000000004424 166.0
HKD2_k127_1525248_7 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000009307 115.0
HKD2_k127_1525248_8 type II secretion system protein E K02652 - - 0.00000000000000000000001876 108.0
HKD2_k127_1525248_9 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.000000000000000000001557 94.0
HKD2_k127_1548621_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 1.991e-252 790.0
HKD2_k127_1548621_1 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007226 511.0
HKD2_k127_1548621_2 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02504,K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002592 265.0
HKD2_k127_1548621_3 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000001425 108.0
HKD2_k127_1548621_4 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000415 76.0
HKD2_k127_1557114_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 2.663e-199 628.0
HKD2_k127_1557114_1 response to copper ion - - - 0.000000000000000000000000000000000000000000000000000000000000000009994 227.0
HKD2_k127_1557114_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000009796 211.0
HKD2_k127_1557114_3 Glycosyl hydrolase family 57 - - - 0.000000000000000000000000000000000000000000000000000003232 199.0
HKD2_k127_1557114_4 PFAM Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000009391 173.0
HKD2_k127_1558029_0 Insulinase (Peptidase family M16) K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 465.0
HKD2_k127_1558029_1 Peptidase M16 domain protein K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003613 372.0
HKD2_k127_1558029_2 SdpI/YhfL protein family - - - 0.0000000000000000000001362 101.0
HKD2_k127_1558029_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000001167 90.0
HKD2_k127_1558029_4 Ribosomal RNA adenine dimethylase - - - 0.00000000003246 72.0
HKD2_k127_156496_0 NADH Ubiquinone plastoquinone (Complex I) K12141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 606.0
HKD2_k127_156496_1 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003789 615.0
HKD2_k127_156496_10 - - - - 0.00000000002381 70.0
HKD2_k127_156496_2 phosphorelay signal transduction system K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008753 474.0
HKD2_k127_156496_3 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 336.0
HKD2_k127_156496_4 Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004976 287.0
HKD2_k127_156496_5 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000104 257.0
HKD2_k127_156496_6 hydrogenase 4 membrane K12140 - - 0.0000000000000000000000000000000000000000000000000000000000000000003687 236.0
HKD2_k127_156496_7 Hemerythrin HHE cation binding domain K07216 - - 0.0000000000000000000000000000000000000000000003002 171.0
HKD2_k127_156496_8 Histidine kinase - - - 0.00000000000000000000000001273 114.0
HKD2_k127_156496_9 - K07803 - - 0.00000000000005069 78.0
HKD2_k127_1589233_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0 1010.0
HKD2_k127_1589233_1 Histidine kinase K07646 - 2.7.13.3 2.934e-215 687.0
HKD2_k127_1589233_2 spermidine synthase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000141 484.0
HKD2_k127_1589233_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003839 351.0
HKD2_k127_1589233_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000002037 242.0
HKD2_k127_1589233_5 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000002601 213.0
HKD2_k127_1589233_6 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000000000000000000000001015 213.0
HKD2_k127_162060_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1287.0
HKD2_k127_162060_1 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 594.0
HKD2_k127_162060_2 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000644 442.0
HKD2_k127_162060_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000002667 158.0
HKD2_k127_162060_4 B12 binding domain K21551 - 2.1.1.106 0.00000000000000000000000000000000008112 149.0
HKD2_k127_1682886_0 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 412.0
HKD2_k127_1682886_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K13926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 398.0
HKD2_k127_1682886_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K01993 - - 0.00000000000000000000000000000000000007546 156.0
HKD2_k127_1696624_0 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000007247 247.0
HKD2_k127_1696624_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000008383 229.0
HKD2_k127_1696624_2 Cytochrome c554 and c-prime - - - 0.00000000000000000004538 91.0
HKD2_k127_169971_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 556.0
HKD2_k127_169971_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 340.0
HKD2_k127_169971_2 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 319.0
HKD2_k127_169971_3 Histidine kinase K07675 - 2.7.13.3 0.0000000000000000000000000006485 123.0
HKD2_k127_169971_4 Cell wall hydrolase autolysin - - - 0.00000000000005249 83.0
HKD2_k127_169971_5 Sporulation and spore germination K06298 - - 0.0000006902 57.0
HKD2_k127_169971_6 Sporulation and spore germination - - - 0.0005401 43.0
HKD2_k127_1736213_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 1.266e-240 762.0
HKD2_k127_1736213_1 Belongs to the NadC ModD family K00767 GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001114 276.0
HKD2_k127_1835095_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 9.431e-221 700.0
HKD2_k127_1835095_1 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 295.0
HKD2_k127_1835095_2 Plays a role in the flagellum-specific transport system K02419 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005453 251.0
HKD2_k127_1835095_3 Role in flagellar biosynthesis K02421 - - 0.000000000000000000000000000000000008237 146.0
HKD2_k127_1835095_4 Role in flagellar biosynthesis K02420 - - 0.000000000000000004927 89.0
HKD2_k127_183754_0 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 1.135e-203 640.0
HKD2_k127_183754_1 Fructose-bisphosphate aldolase class-II - - - 2.237e-201 635.0
HKD2_k127_183754_2 DNA polymerase K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006172 538.0
HKD2_k127_183754_3 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 286.0
HKD2_k127_183754_4 - - - - 0.0000000000000000000000000000000000000000000000000000008064 203.0
HKD2_k127_183754_5 - - - - 0.00000006543 57.0
HKD2_k127_1844221_0 Family 5 K02035,K15580 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 381.0
HKD2_k127_1844221_1 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 290.0
HKD2_k127_1844221_2 -acetyltransferase - - - 0.00000000000000000000000000000004725 133.0
HKD2_k127_1844221_3 anaerobic respiration - - - 0.0000000000000000000000000000002822 134.0
HKD2_k127_1844221_4 Protein of unknown function DUF262 - - - 0.000000000000001567 79.0
HKD2_k127_1844221_5 Peptidase C26 K07010 - - 0.00000000000002518 75.0
HKD2_k127_186407_0 PFAM type II secretion system protein E K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 491.0
HKD2_k127_186407_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001326 241.0
HKD2_k127_1882979_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 5.791e-197 630.0
HKD2_k127_1882979_1 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002361 456.0
HKD2_k127_1882979_2 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 383.0
HKD2_k127_1882979_3 PFAM cytochrome c assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 304.0
HKD2_k127_1882979_4 Mo-molybdopterin cofactor metabolic process K03753,K07588 - - 0.0000000000000000000000000000000000000001089 160.0
HKD2_k127_1882979_5 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.0000000000000000000001696 103.0
HKD2_k127_1882979_6 Protein of unknown function, DUF488 - - - 0.000000000004254 67.0
HKD2_k127_1882979_7 TIGRFAM transcriptional regulator, AbrB family - - - 0.00007976 50.0
HKD2_k127_191342_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1131.0
HKD2_k127_191342_1 Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00124,K00335,K00355,K18331 - 1.12.1.3,1.6.5.2,1.6.5.3 1.664e-256 807.0
HKD2_k127_191342_10 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 - 2.1.1.200,3.5.1.19,6.1.1.16 0.00000000000000000000000000000000000000000000000000006692 198.0
HKD2_k127_191342_11 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.0000000000000000000000000000000000000000000000000005508 190.0
HKD2_k127_191342_12 dTDP-4-dehydrorhamnose 3,5-epimerase activity K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000002039 186.0
HKD2_k127_191342_13 PFAM Pyruvate kinase, alpha beta domain K09126 - - 0.00000000000000000000000000000000000000000000000001543 188.0
HKD2_k127_191342_14 PFAM Cytochrome b(N-terminal) b6 petB - - - 0.000000000000000000000000000000000000000000000003074 182.0
HKD2_k127_191342_15 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000003507 181.0
HKD2_k127_191342_16 heme-binding sites - - - 0.00000000000000000000000000000000000000003132 162.0
HKD2_k127_191342_17 denitrification pathway - - - 0.000000000000000000000000000000000000000216 163.0
HKD2_k127_191342_18 Ferredoxin K17992 - 1.12.1.3 0.00000000000000000000000000000008562 130.0
HKD2_k127_191342_19 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000000000003845 112.0
HKD2_k127_191342_2 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 503.0
HKD2_k127_191342_20 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000002384 106.0
HKD2_k127_191342_21 Bacterial regulatory protein, Fis family - - - 0.00000000000002842 84.0
HKD2_k127_191342_3 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 466.0
HKD2_k127_191342_4 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 441.0
HKD2_k127_191342_5 PFAM Nucleotidyl transferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 429.0
HKD2_k127_191342_6 citrate synthase K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 401.0
HKD2_k127_191342_7 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.000000000000000000000000000000000000000000000000000000000000000000000000000003229 271.0
HKD2_k127_191342_8 Domain of unknown function (DUF4337) - - - 0.000000000000000000000000000000000000000000000000000000000002199 215.0
HKD2_k127_191342_9 Telomere recombination K07566 - 2.7.7.87 0.0000000000000000000000000000000000000000000000000000409 193.0
HKD2_k127_1919946_0 radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007321 436.0
HKD2_k127_1919946_1 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000003416 166.0
HKD2_k127_1919946_2 Exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.000000000000000000000000001261 115.0
HKD2_k127_1919946_3 Sensor histidine kinase response regulator - - - 0.000002542 57.0
HKD2_k127_2079424_0 PFAM Pyridine nucleotide-disulphide oxidoreductase K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 3.19e-271 843.0
HKD2_k127_2079424_1 Cysteine-rich domain K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 393.0
HKD2_k127_2079424_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003617 392.0
HKD2_k127_2079424_3 4Fe-4S dicluster domain K03390,K16887 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000002866 243.0
HKD2_k127_2079424_4 nuclease K01174 GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575 3.1.31.1 0.000000000000000000000000000000000000000001299 168.0
HKD2_k127_2198926_0 Cobalamin (Vitamin B12) biosynthesis CbiM protein K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 384.0
HKD2_k127_2198926_1 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K16787 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 332.0
HKD2_k127_2198926_2 Cobalt transport protein K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001266 261.0
HKD2_k127_2198926_3 cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000009485 69.0
HKD2_k127_2199993_0 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009566 335.0
HKD2_k127_2199993_1 PFAM Phosphoglycerate mutase K02226 - 3.1.3.73 0.00000000000000000000000000000000000000000000000000000000000000000000003274 248.0
HKD2_k127_2199993_2 Cobalamin-5-phosphate synthase K02233 - 2.7.8.26 0.00000000000000000000000000000000000001421 154.0
HKD2_k127_220404_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005409 380.0
HKD2_k127_220404_1 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 310.0
HKD2_k127_220404_10 META domain K03929 - - 0.000000000008891 76.0
HKD2_k127_220404_12 Phosphoribosyl transferase domain K07100 - - 0.0003034 46.0
HKD2_k127_220404_2 TPM domain K06872 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 302.0
HKD2_k127_220404_3 PFAM LemA family protein K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 290.0
HKD2_k127_220404_4 Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) K00768 GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000005057 257.0
HKD2_k127_220404_5 Pfam:TPM K08988 - - 0.00000000000000000000000000000000000000000000000000000000000000004209 234.0
HKD2_k127_220404_6 PFAM periplasmic binding protein K02016 - - 0.0000000000000000000000000000000000000000000000000000000001651 214.0
HKD2_k127_220404_7 ABC transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000379 188.0
HKD2_k127_220404_8 Cobinamide kinase / cobinamide phosphate guanyltransferase K02231 - 2.7.1.156,2.7.7.62 0.000000000000000000000000000000000000000000000008761 177.0
HKD2_k127_220404_9 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000000000000000000000000000000000000000002299 166.0
HKD2_k127_2224218_0 cysteine-tRNA ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008203 445.0
HKD2_k127_2224218_1 galactose-1-phosphate uridylyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 338.0
HKD2_k127_2224218_10 cyclic nucleotide binding K00384,K01420 - 1.8.1.9 0.0000000000000000000332 104.0
HKD2_k127_2224218_11 AMP binding - - - 0.0000000000000000001427 99.0
HKD2_k127_2224218_12 PFAM Response regulator receiver domain - - - 0.00000000000001141 83.0
HKD2_k127_2224218_13 GYD domain - - - 0.00000001718 59.0
HKD2_k127_2224218_2 PFAM glycosyl transferase group 1 K15521 - 2.4.1.250 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 296.0
HKD2_k127_2224218_3 GlcNAc-PI de-N-acetylase K01463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003202 282.0
HKD2_k127_2224218_4 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001125 268.0
HKD2_k127_2224218_5 tRNA modification K06968 - 2.1.1.186 0.000000000000000000000000000000000000000000000000000000000000000000000381 241.0
HKD2_k127_2224218_6 CHASE K02488,K21009 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000006259 253.0
HKD2_k127_2224218_7 Methyltransferase, chemotaxis proteins K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000312 244.0
HKD2_k127_2224218_8 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000005482 241.0
HKD2_k127_2224218_9 OsmC-like protein K07397 - - 0.00000000000000000000000000000000000000000000000000006455 193.0
HKD2_k127_2268671_0 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000067 439.0
HKD2_k127_2268671_1 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000909 328.0
HKD2_k127_2268671_10 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000001083 191.0
HKD2_k127_2268671_11 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000002576 176.0
HKD2_k127_2268671_12 SurA N-terminal domain K03770 - 5.2.1.8 0.000000000000000000000000000000000000000001561 164.0
HKD2_k127_2268671_13 RNA-binding protein containing a PIN domain K06962 - - 0.0000000000000000000000000000000000006022 145.0
HKD2_k127_2268671_14 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000004725 135.0
HKD2_k127_2268671_15 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.000000000000000000255 90.0
HKD2_k127_2268671_2 ParB-like nuclease domain K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 327.0
HKD2_k127_2268671_3 PFAM Cobyrinic acid a,c-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006823 317.0
HKD2_k127_2268671_4 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000000000145 266.0
HKD2_k127_2268671_5 Transcriptional regulatory protein, C terminal K07664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001202 257.0
HKD2_k127_2268671_6 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000002669 267.0
HKD2_k127_2268671_7 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000804 237.0
HKD2_k127_2268671_8 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000004674 209.0
HKD2_k127_2268671_9 PAP2 superfamily - - - 0.00000000000000000000000000000000000000000000000000000005018 207.0
HKD2_k127_2460762_0 General secretory system II, protein E domain protein K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003395 567.0
HKD2_k127_2460762_1 General secretory system II, protein E domain protein K02652 - - 0.0000005439 53.0
HKD2_k127_24759_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1463.0
HKD2_k127_24759_1 Belongs to the CarA family K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 573.0
HKD2_k127_24759_10 response to copper ion K07156,K14166 - - 0.0000000000000000000000000000000531 128.0
HKD2_k127_24759_11 Membrane - - - 0.00000000000000000000000001007 126.0
HKD2_k127_24759_12 - - - - 0.00000003855 57.0
HKD2_k127_24759_13 - - - - 0.00000745 54.0
HKD2_k127_24759_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 527.0
HKD2_k127_24759_3 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 - 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002146 402.0
HKD2_k127_24759_4 long-chain fatty acid transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 397.0
HKD2_k127_24759_5 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005315 347.0
HKD2_k127_24759_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004297 269.0
HKD2_k127_24759_7 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000006751 228.0
HKD2_k127_24759_8 FMN binding - - - 0.00000000000000000000000000000000000000000000000000000000000000007562 228.0
HKD2_k127_24759_9 Evidence 5 No homology to any previously reported sequences K07156,K07245,K14166 - - 0.00000000000000000000000000000000000003075 163.0
HKD2_k127_254112_0 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001115 261.0
HKD2_k127_254112_1 Peptidase family M23 K21471 - - 0.000000000000000000000000000000000000000000000000000000000000000000688 242.0
HKD2_k127_254112_2 ABC transporter K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000009464 236.0
HKD2_k127_254112_3 Belongs to the ABC-4 integral membrane protein family. FtsX subfamily K09811 - - 0.000000000000000000000000000000000000000000000002022 184.0
HKD2_k127_2557502_0 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003474 436.0
HKD2_k127_2557502_1 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 408.0
HKD2_k127_2557502_10 glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000005623 205.0
HKD2_k127_2557502_11 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K14986 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000003748 208.0
HKD2_k127_2557502_12 TIGRFAM cytochrome C family protein - - - 0.000000000000000000000000000000000000000000000000001343 196.0
HKD2_k127_2557502_13 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000000000000000000000000000000006958 194.0
HKD2_k127_2557502_14 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.0000000000000000000000000001736 124.0
HKD2_k127_2557502_15 oligosaccharyl transferase activity - - - 0.000000000000000000000000001188 131.0
HKD2_k127_2557502_16 oligosaccharyl transferase activity - - - 0.000000000000000000000000009061 128.0
HKD2_k127_2557502_17 3-demethylubiquinone-9 3-O-methyltransferase activity K20444 - - 0.0000000000000000005128 97.0
HKD2_k127_2557502_18 Tetratricopeptide repeat - - - 0.0000000003665 74.0
HKD2_k127_2557502_19 Virilizer, N-terminal - GO:0000003,GO:0000375,GO:0000381,GO:0001510,GO:0001667,GO:0002064,GO:0002065,GO:0002066,GO:0003006,GO:0003674,GO:0003676,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0006928,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007297,GO:0007298,GO:0007530,GO:0007538,GO:0007539,GO:0007549,GO:0008150,GO:0008152,GO:0008380,GO:0009451,GO:0009888,GO:0009987,GO:0010467,GO:0010468,GO:0010631,GO:0016020,GO:0016021,GO:0016070,GO:0016071,GO:0016477,GO:0016556,GO:0016604,GO:0016607,GO:0018993,GO:0019219,GO:0019222,GO:0019953,GO:0022412,GO:0022414,GO:0030154,GO:0030707,GO:0030855,GO:0031224,GO:0031323,GO:0031440,GO:0031974,GO:0031981,GO:0032259,GO:0032501,GO:0032502,GO:0032504,GO:0032991,GO:0034641,GO:0034708,GO:0036396,GO:0040011,GO:0040029,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043414,GO:0043484,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0044703,GO:0045293,GO:0046483,GO:0048024,GO:0048468,GO:0048477,GO:0048609,GO:0048856,GO:0048869,GO:0048870,GO:0050684,GO:0050789,GO:0050794,GO:0051171,GO:0051179,GO:0051252,GO:0051674,GO:0051704,GO:0060255,GO:0060429,GO:0065007,GO:0070013,GO:0071704,GO:0080009,GO:0080090,GO:0090130,GO:0090132,GO:0090304,GO:0097159,GO:0110104,GO:1900363,GO:1901360,GO:1901363,GO:1902494,GO:1903311,GO:1990234 - 0.0002646 54.0
HKD2_k127_2557502_2 Polysaccharide biosynthesis protein K03328 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 362.0
HKD2_k127_2557502_3 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 350.0
HKD2_k127_2557502_4 cyclopropane-fatty-acyl-phospholipid synthase K00574,K15256,K15257 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008276 298.0
HKD2_k127_2557502_5 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 302.0
HKD2_k127_2557502_6 Glycosyl transferase family group 2 K07011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 301.0
HKD2_k127_2557502_7 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001466 289.0
HKD2_k127_2557502_8 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001026 287.0
HKD2_k127_2557502_9 methyltransferase activity K00563,K02169 - 2.1.1.187,2.1.1.197 0.000000000000000000000000000000000000000000000000000000000000000000000008416 248.0
HKD2_k127_2560410_0 NeuB family K03856,K04516 - 2.5.1.54,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 428.0
HKD2_k127_2560410_1 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 398.0
HKD2_k127_2560410_2 Fumarate hydratase (Fumerase) K01676,K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000004043 226.0
HKD2_k127_2560410_3 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000001227 228.0
HKD2_k127_2560410_4 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000008682 155.0
HKD2_k127_2560410_5 PFAM Archease protein family (DUF101 UPF0211) - - - 0.00000000000000000000000000000000000007268 146.0
HKD2_k127_2570060_0 COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 439.0
HKD2_k127_2570060_1 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 396.0
HKD2_k127_2570060_2 MlaD protein K06192 - - 0.00000000000008889 72.0
HKD2_k127_2570060_3 MltA-interacting MipA family protein K07274 - - 0.000000000004877 66.0
HKD2_k127_2572750_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 3.339e-203 638.0
HKD2_k127_2572750_1 C-terminal, D2-small domain, of ClpB protein K03696 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 583.0
HKD2_k127_2572750_10 ribonuclease III activity K03685,K07053 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3,3.1.3.97 0.00000000000000000000000000000000000000000000000000001139 199.0
HKD2_k127_2572750_11 AMP binding - - - 0.0000000000000000000000000000000000000000000368 165.0
HKD2_k127_2572750_13 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000000007038 126.0
HKD2_k127_2572750_14 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000003389 123.0
HKD2_k127_2572750_2 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 534.0
HKD2_k127_2572750_3 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 505.0
HKD2_k127_2572750_4 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004909 479.0
HKD2_k127_2572750_5 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 410.0
HKD2_k127_2572750_6 Ion channel K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006495 365.0
HKD2_k127_2572750_7 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 332.0
HKD2_k127_2572750_8 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 330.0
HKD2_k127_2572750_9 Polysaccharide deacetylase K11931 - - 0.00000000000000000000000000000000000000000000000000000000000000000001434 247.0
HKD2_k127_2575594_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 4.536e-233 739.0
HKD2_k127_2575594_1 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002869 423.0
HKD2_k127_2575594_2 Chemotaxis protein methyltransferase K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 348.0
HKD2_k127_2575594_3 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 288.0
HKD2_k127_2575594_4 Cellulose biosynthesis protein BcsQ K04562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005743 288.0
HKD2_k127_2575594_5 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003787 244.0
HKD2_k127_2575594_6 Sigma-70, region 4 K02405 - - 0.000000000000000000000000000000000000000000000000000000001605 209.0
HKD2_k127_2575594_7 cheY-homologous receiver domain K03413 - - 0.000000000000000000000000000000000000000000000000002323 184.0
HKD2_k127_2575594_8 Flagellar biosynthesis regulator FlhF K02404 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000006658 186.0
HKD2_k127_2575594_9 cheY-homologous receiver domain K03413 - - 0.00000000000000000000000000000000000000000199 158.0
HKD2_k127_2583225_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 8.024e-196 615.0
HKD2_k127_2583225_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005925 441.0
HKD2_k127_2583225_2 Histidine kinase K07708 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000007758 197.0
HKD2_k127_2583225_3 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000002585 114.0
HKD2_k127_2584855_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 6.87e-306 949.0
HKD2_k127_2584855_1 Domain in cystathionine beta-synthase and other proteins. K07182 - - 4.718e-248 782.0
HKD2_k127_2584855_10 TIGRFAM transcriptional regulator, Rrf2 family - - - 0.000000000000000000000000000000000003818 143.0
HKD2_k127_2584855_11 Protein of unknown function, DUF485 - - - 0.000000000000000000000000002482 114.0
HKD2_k127_2584855_12 - - - - 0.0000000000002277 73.0
HKD2_k127_2584855_2 glycolate transport K14393 - - 3.95e-232 732.0
HKD2_k127_2584855_3 Domain in cystathionine beta-synthase and other proteins. K07182 - - 1.472e-229 727.0
HKD2_k127_2584855_4 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 456.0
HKD2_k127_2584855_5 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007717 343.0
HKD2_k127_2584855_6 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005508 316.0
HKD2_k127_2584855_7 PFAM Isochorismatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004829 254.0
HKD2_k127_2584855_8 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002566 248.0
HKD2_k127_2584855_9 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.00000000000000000000000000000000000001344 154.0
HKD2_k127_2585654_0 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 1.835e-216 681.0
HKD2_k127_2585654_1 MacB-like periplasmic core domain K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 468.0
HKD2_k127_2585654_2 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003254 438.0
HKD2_k127_2585654_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004321 325.0
HKD2_k127_2585654_4 MiaB-like tRNA modifying enzyme K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 308.0
HKD2_k127_2585654_5 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009383 268.0
HKD2_k127_2585654_6 Tautomerase enzyme K01821 - 5.3.2.6 0.000000000000000000000000005278 112.0
HKD2_k127_2585955_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 7.479e-288 905.0
HKD2_k127_26014_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 553.0
HKD2_k127_26014_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 502.0
HKD2_k127_26014_2 ATP synthase subunit D K02120 - - 0.00000000000000000000000000000000000000000000000000000000000000000001909 239.0
HKD2_k127_261947_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 428.0
HKD2_k127_261947_1 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 346.0
HKD2_k127_261947_2 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000000000000000000000001091 175.0
HKD2_k127_261947_3 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.000000000000000000000000000000000000000000003008 167.0
HKD2_k127_261947_4 Bacterial antitoxin of type II TA system, VapB - - - 0.0000000000000000000002218 98.0
HKD2_k127_2632981_0 heme-copper terminal oxidase activity K02274 - 1.9.3.1 4.893e-239 749.0
HKD2_k127_2632981_1 UPF0210 protein K09157 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 489.0
HKD2_k127_2632981_10 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000001674 210.0
HKD2_k127_2632981_11 - K18700 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0042802,GO:0042803,GO:0046983 3.1.2.29 0.0000000000000000000000000000000000000000000000000000000001011 206.0
HKD2_k127_2632981_12 NTPase - - - 0.000000000000000000000000000000000000313 147.0
HKD2_k127_2632981_13 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.000000000349 65.0
HKD2_k127_2632981_2 cytochrome c peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006157 467.0
HKD2_k127_2632981_3 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 440.0
HKD2_k127_2632981_4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K02297 - 1.10.3.10,1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008787 316.0
HKD2_k127_2632981_5 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000007259 269.0
HKD2_k127_2632981_6 membrane protein, hemolysin III homolog K11068 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000004876 247.0
HKD2_k127_2632981_7 cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000001826 242.0
HKD2_k127_2632981_8 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000009355 231.0
HKD2_k127_2632981_9 protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.0000000000000000000000000000000000000000000000000000000000008214 220.0
HKD2_k127_2634997_0 helicase K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 565.0
HKD2_k127_2634997_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 373.0
HKD2_k127_2634997_2 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001066 274.0
HKD2_k127_2634997_3 PINc domain ribonuclease K09006 - - 0.00000000000000000000000000000000000000000000000000000000000000001502 230.0
HKD2_k127_2634997_4 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000004744 188.0
HKD2_k127_2634997_5 negative regulation of ribosome biogenesis K00969,K09710 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 0.0000000000000000000000000000000001373 135.0
HKD2_k127_2642616_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000001799 222.0
HKD2_k127_2642616_1 protein with SCP PR1 domains - - - 0.0000000000000000000000000000000000000000000001833 173.0
HKD2_k127_2642616_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.000000000000000000000000000006721 123.0
HKD2_k127_2690311_0 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 323.0
HKD2_k127_2690311_1 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000001067 240.0
HKD2_k127_2690311_2 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000000000002209 213.0
HKD2_k127_2690311_3 PFAM Nitrate reductase gamma subunit - - - 0.00000000000000000001744 100.0
HKD2_k127_2690311_4 - - - - 0.000000000000007574 79.0
HKD2_k127_2715768_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1677.0
HKD2_k127_2715768_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 6.623e-277 870.0
HKD2_k127_2715768_10 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000000000000000001032 248.0
HKD2_k127_2715768_11 PFAM ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001702 244.0
HKD2_k127_2715768_12 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000009455 228.0
HKD2_k127_2715768_13 TIGRFAM FeS cluster assembly scaffold protein NifU K04488 - - 0.000000000000000000000000000000000000000000000000000000000134 205.0
HKD2_k127_2715768_14 Glycosyl transferase family group 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000000148 211.0
HKD2_k127_2715768_15 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.00000000000000000000000000000000000000000000000000004308 192.0
HKD2_k127_2715768_16 Glycoprotease family K14742 - - 0.00000000000000000000000000000000000000000000000001173 188.0
HKD2_k127_2715768_17 isopentenyl-diphosphate delta-isomerase activity K00949,K01823 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.7.6.2,5.3.3.2 0.0000000000000000000000000000000000000000000000004725 181.0
HKD2_k127_2715768_18 YbbR-like protein - - - 0.0000000000000000000000000000000000000000001224 166.0
HKD2_k127_2715768_19 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000009086 164.0
HKD2_k127_2715768_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 601.0
HKD2_k127_2715768_20 Transcriptional regulator - - - 0.0000000000000000000000000000000000000007319 153.0
HKD2_k127_2715768_21 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.00000000000000000000000000000000000001498 150.0
HKD2_k127_2715768_22 Domain of unknown function (DUF4412) - - - 0.0000000000000000000000000000000000007227 147.0
HKD2_k127_2715768_23 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.000000000000000000000000000000000941 136.0
HKD2_k127_2715768_24 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000003545 127.0
HKD2_k127_2715768_25 peroxiredoxin activity - - - 0.00000000000000000000000000001861 124.0
HKD2_k127_2715768_26 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000001037 116.0
HKD2_k127_2715768_27 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000001148 113.0
HKD2_k127_2715768_28 Sulfurtransferase TusA - - - 0.0000000000000000000000004825 106.0
HKD2_k127_2715768_29 - - - - 0.00000372 50.0
HKD2_k127_2715768_3 ferrous iron transmembrane transporter activity K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006344 610.0
HKD2_k127_2715768_4 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005 588.0
HKD2_k127_2715768_5 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 513.0
HKD2_k127_2715768_6 COG1104 Cysteine sulfinate desulfinase cysteine desulfurase K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006743 441.0
HKD2_k127_2715768_7 Competence protein K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 396.0
HKD2_k127_2715768_8 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 310.0
HKD2_k127_2715768_9 HDOD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003557 313.0
HKD2_k127_27163_0 ferrous iron binding K06990,K09141 - - 0.000000000000000000000000000000000000000000000000000000009793 203.0
HKD2_k127_27163_1 metalloendopeptidase activity K03799 - - 0.0000000000000000000000003445 117.0
HKD2_k127_27163_2 phosphorelay signal transduction system - - - 0.0000000005077 68.0
HKD2_k127_2731603_0 Elongation factor SelB, winged helix K03833 - - 5.949e-212 676.0
HKD2_k127_2731603_1 L-seryl-tRNASec selenium transferase activity K01042 GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 473.0
HKD2_k127_2731603_2 redox protein regulator of disulfide bond formation K07397 - - 0.00000000000000000000000005046 113.0
HKD2_k127_2731603_3 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00005036 45.0
HKD2_k127_275125_0 Domain of unknown function (DUF4139) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000461 552.0
HKD2_k127_275125_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007169 486.0
HKD2_k127_2798171_0 Haem-binding uptake, Tiki superfamily, ChaN - - - 3.441e-215 703.0
HKD2_k127_2798171_1 Domain of unknown function (DUF4070) - - - 1.892e-211 668.0
HKD2_k127_2798171_10 - - - - 0.0000000000000000000000000000000000000000000000000002582 209.0
HKD2_k127_2798171_11 NADH dehydrogenase K03885 GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019646,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0036094,GO:0042592,GO:0043167,GO:0043168,GO:0044237,GO:0044425,GO:0044464,GO:0045333,GO:0048037,GO:0048878,GO:0050136,GO:0050660,GO:0050662,GO:0050801,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0097159,GO:0098771,GO:0098796,GO:1901265,GO:1901363,GO:1902494 1.6.99.3 0.00000000000000000000000000000000000000000000000001992 194.0
HKD2_k127_2798171_12 zinc-ribbon domain - - - 0.0000000000000000000000000000000000000001412 152.0
HKD2_k127_2798171_13 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000002051 159.0
HKD2_k127_2798171_14 translation release factor activity - - - 0.00000000000000000000000000000000000006242 147.0
HKD2_k127_2798171_15 Histidine phosphatase superfamily (branch 1) K08296 - - 0.0000000000000000000000000000000000003739 145.0
HKD2_k127_2798171_16 Transglycosylase associated protein - - - 0.000000000000000000000000000000003648 130.0
HKD2_k127_2798171_17 - - - - 0.00000000000000000003905 99.0
HKD2_k127_2798171_18 - - - - 0.00000007152 59.0
HKD2_k127_2798171_19 Sporulation related domain K16081 - - 0.000001013 59.0
HKD2_k127_2798171_2 PLD-like domain K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 551.0
HKD2_k127_2798171_20 PFAM Lytic transglycosylase catalytic - - - 0.000002287 57.0
HKD2_k127_2798171_3 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009525 481.0
HKD2_k127_2798171_4 Belongs to the N(4) N(6)-methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 455.0
HKD2_k127_2798171_5 Restriction endonuclease XhoI K01155 - 3.1.21.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006977 336.0
HKD2_k127_2798171_6 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.00000000000000000000000000000000000000000000000000000000001561 211.0
HKD2_k127_2798171_7 Cytochrome c3 - - - 0.0000000000000000000000000000000000000000000000000000000006362 203.0
HKD2_k127_2798171_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000008961 222.0
HKD2_k127_2798171_9 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.00000000000000000000000000000000000000000000000000000001603 209.0
HKD2_k127_2805895_0 response to heat K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 470.0
HKD2_k127_2805895_1 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006876 471.0
HKD2_k127_2805895_2 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 289.0
HKD2_k127_2805895_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005976 250.0
HKD2_k127_2805895_4 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000005066 227.0
HKD2_k127_2805895_5 - - - - 0.000000000000000000000000000000000000000000000002898 176.0
HKD2_k127_2805895_6 Nodulation protein S (NodS) - - - 0.0000000000000000000000000000000000000001092 159.0
HKD2_k127_2805895_7 UTRA K03710 - - 0.0000000000000000000000000000000001018 142.0
HKD2_k127_2805895_8 Universal stress protein family K07090 - - 0.0001689 46.0
HKD2_k127_2805895_9 Pfam:DUF1049 - - - 0.0002372 48.0
HKD2_k127_28140_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 8.548e-297 917.0
HKD2_k127_28140_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 7.673e-203 642.0
HKD2_k127_28140_10 Predicted permease YjgP/YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000006708 244.0
HKD2_k127_28140_11 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000009653 231.0
HKD2_k127_28140_12 Protein of unknown function DUF47 K07220 - - 0.000000000000000000000000000000000000000000000000000000009476 204.0
HKD2_k127_28140_13 - - - - 0.000000000000000000000000000000000000000000000000000003349 198.0
HKD2_k127_28140_14 C4-type zinc ribbon domain K07164 - - 0.000000000000000000000000000000000000001071 157.0
HKD2_k127_28140_15 GatB Yqey domain protein K09117 - - 0.0000000000000000000000000000000003913 136.0
HKD2_k127_28140_16 permease YjgP YjgQ family K11720 - - 0.0000000000000000000000000000000008205 145.0
HKD2_k127_28140_17 ATP synthesis coupled proton transport K02109 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0016020,GO:0016469,GO:0032991,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 - 0.0000000000000000000001529 102.0
HKD2_k127_28140_18 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000002453 91.0
HKD2_k127_28140_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002991 489.0
HKD2_k127_28140_3 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004983 444.0
HKD2_k127_28140_4 Phosphate transporter family K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 409.0
HKD2_k127_28140_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007627 410.0
HKD2_k127_28140_6 Transcriptional regulator K11921,K19338 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 396.0
HKD2_k127_28140_7 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 393.0
HKD2_k127_28140_9 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826,K02619 - 2.6.1.42,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006126 284.0
HKD2_k127_2869361_0 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007593 474.0
HKD2_k127_2869361_1 DivIVA protein K04074 - - 0.000000000000000000000000000000000000000000000000000000000000000008365 228.0
HKD2_k127_2869361_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000000000000000000000000000000000000001138 216.0
HKD2_k127_2869361_3 PFAM response regulator receiver K02483,K07658,K07668 - - 0.000000000000000000000000000001222 125.0
HKD2_k127_2869361_4 YGGT family K02221 - - 0.0008195 42.0
HKD2_k127_289531_0 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 2.043e-304 962.0
HKD2_k127_289531_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000107 216.0
HKD2_k127_289531_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000008436 213.0
HKD2_k127_2940209_0 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 2.062e-237 751.0
HKD2_k127_2940209_1 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 7.366e-196 616.0
HKD2_k127_2940209_10 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002171 243.0
HKD2_k127_2940209_11 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704,K20453 - 4.2.1.33,4.2.1.35,4.2.1.85 0.000000000000000000000000000000000000000000000000000000000000001563 221.0
HKD2_k127_2940209_12 PFAM OmpA MotB domain protein K02557 - - 0.000000000000000000000000000000000000000000000003599 180.0
HKD2_k127_2940209_13 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000000005488 153.0
HKD2_k127_2940209_14 diguanylate cyclase - - - 0.0000000000000000000000000000000004601 138.0
HKD2_k127_2940209_15 Belongs to the peptidase M16 family K07263 - - 0.00000000000001022 80.0
HKD2_k127_2940209_16 - - - - 0.00000000001134 74.0
HKD2_k127_2940209_17 PFAM flagellar protein FliS K02422 - - 0.00000000001604 70.0
HKD2_k127_2940209_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002861 574.0
HKD2_k127_2940209_3 S-adenosylhomocysteine deaminase activity K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 498.0
HKD2_k127_2940209_4 metal-dependent phosphohydrolase HD region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001241 366.0
HKD2_k127_2940209_5 Metal-dependent phosphohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000898 358.0
HKD2_k127_2940209_6 MotA/TolQ/ExbB proton channel family K02556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 331.0
HKD2_k127_2940209_7 MotA/TolQ/ExbB proton channel family K02556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001307 278.0
HKD2_k127_2940209_8 PFAM flagellin domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006256 278.0
HKD2_k127_2940209_9 Flagellar Motor Protein K02557 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009288,GO:0009425,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044425,GO:0044459,GO:0044461,GO:0044463,GO:0044464,GO:0071944,GO:0120100,GO:0120101 - 0.00000000000000000000000000000000000000000000000000000000000000000000000005781 258.0
HKD2_k127_2942124_0 Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 591.0
HKD2_k127_2942124_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07644 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 478.0
HKD2_k127_2942124_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009028 477.0
HKD2_k127_2942124_3 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004005 357.0
HKD2_k127_2942124_4 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 312.0
HKD2_k127_2942124_5 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002337 282.0
HKD2_k127_2942124_6 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01535 - 3.6.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000002069 258.0
HKD2_k127_2942124_7 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000000000000000000000001078 245.0
HKD2_k127_2942124_8 Belongs to the sulfur carrier protein TusA family - - - 0.00000000000000000001223 93.0
HKD2_k127_2942124_9 PFAM transposase, IS4 family protein - - - 0.0000005482 58.0
HKD2_k127_2958343_0 CO dehydrogenase flavoprotein C-terminal domain K11178 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003027 407.0
HKD2_k127_2958343_1 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 389.0
HKD2_k127_2958343_2 amine oxidase K01854 - 5.4.99.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 355.0
HKD2_k127_2958343_3 XdhC and CoxI family K07402 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008697 251.0
HKD2_k127_2958343_4 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K07141 - 2.7.7.76 0.000000000000000000000000000000000000000000000002126 180.0
HKD2_k127_297806_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1590.0
HKD2_k127_29976_0 acetyl-CoA catabolic process K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 511.0
HKD2_k127_29976_1 one-carbon metabolic process K00194,K00198 - 1.2.7.4,2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 392.0
HKD2_k127_29976_2 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 388.0
HKD2_k127_29976_3 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005476 326.0
HKD2_k127_29976_4 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001511 277.0
HKD2_k127_29976_5 PFAM Cobyrinic acid ac-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002551 266.0
HKD2_k127_3033500_0 Belongs to the peptidase S16 family - - - 5.337e-249 792.0
HKD2_k127_3033500_1 Domains REC, sigma54 interaction, HTH8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009099 492.0
HKD2_k127_3033500_2 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 317.0
HKD2_k127_3033500_3 RNase_H superfamily K07502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002271 278.0
HKD2_k127_3033500_4 PFAM lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000000008907 261.0
HKD2_k127_3033500_5 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000008474 241.0
HKD2_k127_3033500_6 Signal transduction histidine kinase, phosphotransfer (Hpt) - - - 0.00000000000000000000000000000001314 143.0
HKD2_k127_3116723_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 552.0
HKD2_k127_3116723_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002799 478.0
HKD2_k127_3116723_2 Flavodoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 381.0
HKD2_k127_3116723_3 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008958 309.0
HKD2_k127_3116723_4 Ferritin-like domain K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000004574 182.0
HKD2_k127_3116723_5 - - - - 0.0000000000000000000000000000000000000000004911 162.0
HKD2_k127_3116723_6 rubredoxin - - - 0.0000000000000000001343 90.0
HKD2_k127_3121740_0 PFAM V-type ATPase 116 kDa K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008218 594.0
HKD2_k127_3121740_1 PFAM thiamine pyrophosphate protein domain protein TPP-binding K09459 - 4.1.1.82 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 314.0
HKD2_k127_3121740_2 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009009 306.0
HKD2_k127_3121740_3 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0000000000000000000000000000000000000000000000000000002621 203.0
HKD2_k127_3121740_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000000009765 117.0
HKD2_k127_3121740_6 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.0000000000000000000000311 101.0
HKD2_k127_3121740_7 - - - - 0.0000000000000000000004522 98.0
HKD2_k127_3121740_8 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.00000000000005173 75.0
HKD2_k127_3200884_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 535.0
HKD2_k127_3200884_1 Protein of unknown function (DUF3187) - - - 0.000000000000000000000002404 114.0
HKD2_k127_3279634_0 Beta-lactamase - - - 9.755e-283 890.0
HKD2_k127_3279634_1 Predicted permease K07089 - - 1.982e-239 755.0
HKD2_k127_3279634_10 peptidylprolyl isomerase K07533 - 5.2.1.8 0.0001715 53.0
HKD2_k127_3279634_2 SMART Elongator protein 3 MiaB NifB K22226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 490.0
HKD2_k127_3279634_3 Putative glycosyl hydrolase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004892 483.0
HKD2_k127_3279634_4 PFAM Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002527 326.0
HKD2_k127_3279634_5 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000002422 239.0
HKD2_k127_3279634_6 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000834 162.0
HKD2_k127_3279634_8 - - - - 0.000000000000000000000001072 108.0
HKD2_k127_3279634_9 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.000000000001216 80.0
HKD2_k127_3398830_0 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002974 362.0
HKD2_k127_3398830_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002604 353.0
HKD2_k127_3398830_2 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005436 286.0
HKD2_k127_3398830_3 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0031347,GO:0031348,GO:0034214,GO:0035821,GO:0040007,GO:0042802,GO:0043170,GO:0043207,GO:0043545,GO:0043933,GO:0044003,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0046483,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0061799,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0075136,GO:0080134,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.17 0.000000000000000000000000000000000000000000000000000006622 194.0
HKD2_k127_3398830_4 Outer membrane lipoprotein - - - 0.000000000000000000000000000000000000000000001924 177.0
HKD2_k127_3398830_5 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000000000000009911 160.0
HKD2_k127_3398830_6 energy transducer activity K03646,K03832 - - 0.00000000000004694 81.0
HKD2_k127_3398830_7 PFAM Positive regulator of sigma(E) RseC MucC K03803 - - 0.000001734 56.0
HKD2_k127_3398830_8 PilZ domain - - - 0.00009713 50.0
HKD2_k127_342321_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 537.0
HKD2_k127_342321_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 477.0
HKD2_k127_342321_10 PFAM methyl-viologen-reducing hydrogenase delta subunit - - - 0.000000000000000000007266 93.0
HKD2_k127_342321_2 CO dehydrogenase/acetyl-CoA synthase delta subunit K00194 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 331.0
HKD2_k127_342321_3 Methylene-tetrahydrofolate reductase C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 295.0
HKD2_k127_342321_4 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002716 277.0
HKD2_k127_342321_5 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000191 261.0
HKD2_k127_342321_6 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000004656 224.0
HKD2_k127_342321_7 Transcriptional regulator - - - 0.00000000000000000000000000000000000002271 152.0
HKD2_k127_342321_8 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.0000000000000000000000000000000000003812 141.0
HKD2_k127_342321_9 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000001571 123.0
HKD2_k127_357595_0 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003457 422.0
HKD2_k127_357595_1 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 322.0
HKD2_k127_357595_10 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000001223 171.0
HKD2_k127_357595_11 cytochrome c biogenesis protein - - - 0.0000000000000000000000000000000000000234 153.0
HKD2_k127_357595_12 Protein of unknown function (DUF1573) - - - 0.0000000002945 62.0
HKD2_k127_357595_14 YMGG-like Gly-zipper - - - 0.00003361 53.0
HKD2_k127_357595_2 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 321.0
HKD2_k127_357595_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 317.0
HKD2_k127_357595_4 cytochrome complex assembly - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004747 250.0
HKD2_k127_357595_5 Protein of unknown function (DUF1499) - - - 0.000000000000000000000000000000000000000000000000000000000000003456 226.0
HKD2_k127_357595_6 PFAM VacJ family lipoprotein K04754 - - 0.000000000000000000000000000000000000000000000000000000000002469 218.0
HKD2_k127_357595_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07323 - - 0.000000000000000000000000000000000000000000000000000005079 197.0
HKD2_k127_357595_8 Protein of unknown function (DUF1003) - - - 0.00000000000000000000000000000000000000000000000000006938 190.0
HKD2_k127_357595_9 protocatechuate 3,4-dioxygenase - - - 0.0000000000000000000000000000000000000000000000002777 179.0
HKD2_k127_3576374_0 Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001641 505.0
HKD2_k127_3576374_1 Zn-dependent metallo-hydrolase RNA specificity domain K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007106 407.0
HKD2_k127_3576374_2 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3,2.1.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 376.0
HKD2_k127_3576374_3 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - 0.0000000000000000000000000000000000000000000000000000000002685 219.0
HKD2_k127_362_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 521.0
HKD2_k127_362_1 ABC transporter K09817 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000302 258.0
HKD2_k127_362_10 TIGRFAM hydrogenase maturation protease K08315 - 3.4.23.51 0.00002191 47.0
HKD2_k127_362_2 PFAM periplasmic solute binding protein K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000005829 231.0
HKD2_k127_362_3 ABC 3 transport family K09816,K09819 - - 0.000000000000000000000000000000000000000000000000000000000000002073 227.0
HKD2_k127_362_4 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000001058 159.0
HKD2_k127_362_5 PFAM GCN5-related N-acetyltransferase - - - 0.000000000000000000000000000000001018 136.0
HKD2_k127_362_7 NAD(P)H-binding K01784 - 5.1.3.2 0.0000000000000000000000006148 117.0
HKD2_k127_362_9 - - - - 0.000000835 50.0
HKD2_k127_383384_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 3.987e-229 729.0
HKD2_k127_383384_1 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004546 451.0
HKD2_k127_383384_10 4Fe-4S binding domain - - - 0.00001091 48.0
HKD2_k127_383384_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004926 385.0
HKD2_k127_383384_3 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000000000000000000000000000000000000000000000000000000000000000000001306 262.0
HKD2_k127_383384_4 PINc domain ribonuclease K09006 - - 0.00000000000000000000000000000000000000000000000000000000000000006019 229.0
HKD2_k127_383384_5 Signal transduction histidine kinase, nitrogen specific, NtrB K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000002042 238.0
HKD2_k127_383384_6 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000006185 143.0
HKD2_k127_383384_7 Uncharacterized conserved protein (DUF2249) - - - 0.0000000000000000000000000004123 115.0
HKD2_k127_383384_8 Domain of unknown function (DUF1858) - - - 0.00000000000000001672 83.0
HKD2_k127_383384_9 negative regulation of ribosome biogenesis K00969,K09710 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 2.7.7.18 0.0000000000000006159 78.0
HKD2_k127_3866771_0 Trypsin K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 548.0
HKD2_k127_3866771_1 Trypsin K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 435.0
HKD2_k127_3866771_10 protein histidine kinase activity K01768,K03406,K07636,K07716,K17763 - 2.7.13.3,4.6.1.1 0.00000000000000000000000000000003218 134.0
HKD2_k127_3866771_2 Cell wall formation K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 394.0
HKD2_k127_3866771_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007543 393.0
HKD2_k127_3866771_4 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002733 389.0
HKD2_k127_3866771_5 Transporter K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009191 321.0
HKD2_k127_3866771_6 TIGRFAM Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000002068 187.0
HKD2_k127_3866771_7 HNH nucleases - - - 0.0000000000000000000000000000000000000000002449 160.0
HKD2_k127_3866771_8 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000001375 161.0
HKD2_k127_3866771_9 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K01921,K03589,K06438 GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 6.3.2.4 0.000000000000000000000000000000004547 138.0
HKD2_k127_386764_0 ABC transporter K06158 - - 5.747e-240 756.0
HKD2_k127_386764_1 PFAM Alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009707 321.0
HKD2_k127_386764_2 Diacylglycerol kinase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001424 248.0
HKD2_k127_386764_3 Beta-lactamase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001643 241.0
HKD2_k127_386764_4 6-carboxyhexanoate--CoA ligase K01906 - 6.2.1.14 0.000000000000000000000000000000000000000000000000000001878 201.0
HKD2_k127_386764_5 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000001714 151.0
HKD2_k127_3875363_0 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 419.0
HKD2_k127_3875363_1 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001758 240.0
HKD2_k127_3875363_2 Peptidase family M54 K06974 - - 0.00000000000000000000000000000000000000000000000463 177.0
HKD2_k127_3877197_0 PFAM Polysulphide reductase, NrfD K00185 - - 3.282e-228 720.0
HKD2_k127_3877197_1 PFAM Radical SAM K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007634 598.0
HKD2_k127_3877197_2 - K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004802 421.0
HKD2_k127_3877197_3 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004576 377.0
HKD2_k127_3877197_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000005267 177.0
HKD2_k127_3877197_5 helix_turn_helix, cAMP Regulatory protein K10914,K21563 - - 0.000000000000000000000000001715 121.0
HKD2_k127_3877197_6 Universal stress protein family - - - 0.00000004816 58.0
HKD2_k127_3878753_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 2.313e-212 666.0
HKD2_k127_3878753_1 Metallopeptidase family M24 K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008562 336.0
HKD2_k127_3878753_2 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.00000000000000000000000000000000000000000000000000000000000005741 217.0
HKD2_k127_3878753_3 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000003701 193.0
HKD2_k127_3878753_4 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000000000007973 192.0
HKD2_k127_3878753_5 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000009277 166.0
HKD2_k127_3878753_6 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.000000000000000000000000000000005468 128.0
HKD2_k127_3878753_7 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000005466 117.0
HKD2_k127_3878753_8 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000000002548 73.0
HKD2_k127_388613_0 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 1.898e-215 674.0
HKD2_k127_388613_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 541.0
HKD2_k127_388613_2 ThiS family K03636 - - 0.00000000000000000000000000000000001504 136.0
HKD2_k127_388613_3 NIL - - - 0.0000000000000000000000000000006639 123.0
HKD2_k127_388613_4 Proposed homoserine kinase K15635 - 5.4.2.12 0.0000000000000000000003958 96.0
HKD2_k127_3886928_0 peptidyl-tyrosine sulfation - - - 0.0000000001623 73.0
HKD2_k127_3886928_1 LysM domain - - - 0.0000000001857 73.0
HKD2_k127_3889418_0 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002795 352.0
HKD2_k127_3889418_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000001485 72.0
HKD2_k127_3889418_2 Tetratricopeptide repeat K06665 GO:0000122,GO:0000228,GO:0000785,GO:0000790,GO:0000988,GO:0000989,GO:0001076,GO:0001190,GO:0001191,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005737,GO:0006139,GO:0006323,GO:0006325,GO:0006333,GO:0006338,GO:0006342,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016458,GO:0016584,GO:0017053,GO:0018130,GO:0019216,GO:0019217,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0022607,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031497,GO:0031974,GO:0031981,GO:0032774,GO:0032879,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0034728,GO:0035950,GO:0035952,GO:0035953,GO:0035955,GO:0040029,GO:0042304,GO:0042826,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0045814,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045944,GO:0046483,GO:0046890,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0060255,GO:0062012,GO:0065007,GO:0070013,GO:0071103,GO:0071704,GO:0071824,GO:0071840,GO:0072364,GO:0080090,GO:0080134,GO:0080135,GO:0090087,GO:0090088,GO:0090089,GO:0090304,GO:0090568,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2000531,GO:2000877,GO:2000879,GO:2001020,GO:2001141 - 0.000000002409 67.0
HKD2_k127_390798_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K13378 - 1.6.5.3 2.161e-299 926.0
HKD2_k127_390798_1 HD domain K07023 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 560.0
HKD2_k127_390798_10 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.0000000000000000000000000000008448 123.0
HKD2_k127_390798_11 4 iron, 4 sulfur cluster binding K00176 - 1.2.7.3 0.000000000000000000002104 96.0
HKD2_k127_390798_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 410.0
HKD2_k127_390798_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008374 340.0
HKD2_k127_390798_4 Cytochrome b/b6/petB K00412,K03888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 312.0
HKD2_k127_390798_5 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000002776 217.0
HKD2_k127_390798_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - - 0.000000000000000000000000000000000000000000000003225 174.0
HKD2_k127_390798_7 NADH dehydrogenase (ubiquinone) activity K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.0000000000000000000000000000000000000000000319 166.0
HKD2_k127_390798_8 Rieske [2Fe-2S] domain K02636,K03886 - 1.10.9.1 0.000000000000000000000000000000000001276 144.0
HKD2_k127_390798_9 Thiamine-binding protein - - - 0.0000000000000000000000000000000000109 138.0
HKD2_k127_3908496_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K01598,K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 368.0
HKD2_k127_3908496_1 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000001676 230.0
HKD2_k127_3908496_2 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000001399 178.0
HKD2_k127_3908496_3 PFAM YicC-like family, N-terminal region - - - 0.00000000000000000000000000000000000002004 150.0
HKD2_k127_3908496_4 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000000000000000003868 133.0
HKD2_k127_3908496_5 Domain of unknown function (DUF370) K09777 - - 0.000000000000000000000000000003836 126.0
HKD2_k127_3908496_6 Tetratricopeptide repeat - - - 0.00000000000000000000003975 111.0
HKD2_k127_3908496_7 Roadblock/LC7 domain - - - 0.00000000000000000000004846 102.0
HKD2_k127_3927647_0 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009673 460.0
HKD2_k127_3927647_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 391.0
HKD2_k127_3927647_2 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 368.0
HKD2_k127_3927647_3 Pfam Anion-transporting ATPase K01551,K19171 - 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007352 274.0
HKD2_k127_3927647_4 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000007086 197.0
HKD2_k127_3930331_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 544.0
HKD2_k127_3930331_1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000754 507.0
HKD2_k127_3930331_2 Cell cycle protein K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003307 424.0
HKD2_k127_3930331_3 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 411.0
HKD2_k127_3930331_4 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 388.0
HKD2_k127_3930331_5 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000002203 267.0
HKD2_k127_3930331_6 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain K00075 - 1.3.1.98 0.000000000000000000000000000004291 126.0
HKD2_k127_3934787_0 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 408.0
HKD2_k127_3934787_1 Mechanosensitive ion channel K03442 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003961 389.0
HKD2_k127_3934787_2 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 335.0
HKD2_k127_3934787_3 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000003318 212.0
HKD2_k127_3934787_4 Protein of unknown function DUF116 K09729 - - 0.000000000000000000000000000000000000000000000000000000000005088 214.0
HKD2_k127_3934787_5 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000004267 218.0
HKD2_k127_3934787_6 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000003623 203.0
HKD2_k127_3938586_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.081e-292 907.0
HKD2_k127_3938586_1 ROK family K00845,K13967,K19979,K20433 - 2.7.1.188,2.7.1.2,2.7.1.214,2.7.1.60,5.1.3.9 0.00000000000000000000000000000000000000000000000000000000000000000009488 240.0
HKD2_k127_3945165_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 355.0
HKD2_k127_3945165_1 HEAT repeats - - - 0.0000000000000000000000000000001845 133.0
HKD2_k127_3945642_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01006 - 2.7.9.1 0.0 1197.0
HKD2_k127_3945642_1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 3.898e-295 913.0
HKD2_k127_3945642_10 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009208 480.0
HKD2_k127_3945642_11 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 426.0
HKD2_k127_3945642_12 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008948 391.0
HKD2_k127_3945642_13 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 381.0
HKD2_k127_3945642_14 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 377.0
HKD2_k127_3945642_15 HD domain K07814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 369.0
HKD2_k127_3945642_16 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 360.0
HKD2_k127_3945642_17 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007365 323.0
HKD2_k127_3945642_18 lipopolysaccharide transport protein B ATP-binding component of ABC superfamily K01990,K06861 GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 289.0
HKD2_k127_3945642_19 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002407 262.0
HKD2_k127_3945642_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 3.335e-276 865.0
HKD2_k127_3945642_20 Appr-1'-p processing enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000001373 235.0
HKD2_k127_3945642_21 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.000000000000000000000000000000000000000000000000000281 190.0
HKD2_k127_3945642_22 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000002042 134.0
HKD2_k127_3945642_23 OstA-like protein K09774 - - 0.0000000000000000000000000000000006345 136.0
HKD2_k127_3945642_24 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000009115 130.0
HKD2_k127_3945642_25 PFAM PKD domain containing protein K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000005759 139.0
HKD2_k127_3945642_26 bacterial (prokaryotic) histone like domain K04764 - - 0.00000000000000000000000006413 110.0
HKD2_k127_3945642_27 Protein of unknown function (DUF465) K09794 - - 0.000000000000000001244 88.0
HKD2_k127_3945642_28 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000007197 91.0
HKD2_k127_3945642_29 - - - - 0.000000000000009754 76.0
HKD2_k127_3945642_3 Dehydratase family K01687 - 4.2.1.9 7.53e-271 842.0
HKD2_k127_3945642_30 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.000000006646 60.0
HKD2_k127_3945642_31 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA K11719 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0017089,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264 - 0.000001651 56.0
HKD2_k127_3945642_4 PFAM Radical SAM domain protein K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003378 598.0
HKD2_k127_3945642_5 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007528 584.0
HKD2_k127_3945642_6 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 536.0
HKD2_k127_3945642_7 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000638 507.0
HKD2_k127_3945642_8 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 507.0
HKD2_k127_3945642_9 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00174,K00186 - 1.2.7.11,1.2.7.3,1.2.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003797 479.0
HKD2_k127_3961303_0 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 317.0
HKD2_k127_3961303_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000001285 177.0
HKD2_k127_3982886_0 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 414.0
HKD2_k127_3982886_1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 347.0
HKD2_k127_3982886_2 ABC transporter K01996,K11963 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002783 314.0
HKD2_k127_3982886_3 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000003667 268.0
HKD2_k127_3982886_5 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000001261 150.0
HKD2_k127_3982886_6 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000002158 123.0
HKD2_k127_3982886_7 chemotaxis, protein K03776 - - 0.0003061 52.0
HKD2_k127_4022868_0 PFAM Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 569.0
HKD2_k127_4022868_1 4 iron, 4 sulfur cluster binding K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 363.0
HKD2_k127_4022868_2 Universal stress protein family - - - 0.000000000000000000000000000000000000021 148.0
HKD2_k127_4022868_3 - - - - 0.0000000000000000000000000002664 113.0
HKD2_k127_4022868_4 cheY-homologous receiver domain - - - 0.000000000000000002937 87.0
HKD2_k127_4034434_0 ThiF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006198 381.0
HKD2_k127_4034434_1 JAB/MPN domain K21140 - 3.13.1.6 0.000000000000000000000000000000005975 132.0
HKD2_k127_4034434_2 Belongs to the sulfur carrier protein TusA family - - - 0.00000000000000000002173 92.0
HKD2_k127_4034434_3 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 0.000000000006014 66.0
HKD2_k127_4084138_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0 1176.0
HKD2_k127_4084138_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0 1143.0
HKD2_k127_4084138_10 PFAM response regulator receiver K07658 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 289.0
HKD2_k127_4084138_11 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000005168 240.0
HKD2_k127_4084138_12 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.000000000000000000000000000000000000000000000000000000002274 204.0
HKD2_k127_4084138_13 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000005109 171.0
HKD2_k127_4084138_14 PFAM Copper amine oxidase N-terminal domain K01448 - 3.5.1.28 0.000000000000009052 85.0
HKD2_k127_4084138_15 Sporulation and spore germination - - - 0.0000000005357 67.0
HKD2_k127_4084138_2 Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 8.933e-321 986.0
HKD2_k127_4084138_3 FMN binding - - - 9.538e-276 854.0
HKD2_k127_4084138_4 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 6.477e-263 822.0
HKD2_k127_4084138_5 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 429.0
HKD2_k127_4084138_6 Peptidase family M48 K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005609 411.0
HKD2_k127_4084138_7 Protein of unknown function (DUF3365) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 421.0
HKD2_k127_4084138_8 Ribonuclease R winged-helix domain K09720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 386.0
HKD2_k127_4084138_9 PFAM Glutamine amidotransferase, class-II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 299.0
HKD2_k127_4086124_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007441 362.0
HKD2_k127_4086124_1 Protein of unknown function (DUF1015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 362.0
HKD2_k127_4086124_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.0000000000000000000000000000000000000000000000000000003484 195.0
HKD2_k127_4109211_0 Belongs to the thiolase family K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007463 486.0
HKD2_k127_4109211_1 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008994 346.0
HKD2_k127_4109211_10 DNA/RNA hybrid annealing activity K07012 - - 0.00005305 49.0
HKD2_k127_4109211_2 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 334.0
HKD2_k127_4109211_3 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001108 279.0
HKD2_k127_4109211_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001687 260.0
HKD2_k127_4109211_5 Domain of unknown function (DUF4337) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005743 243.0
HKD2_k127_4109211_6 Prokaryotic cytochrome b561 - - - 0.0000000000000000000000000000000000000000000000000000000000002227 224.0
HKD2_k127_4109211_7 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000001205 179.0
HKD2_k127_4109211_8 HEPN domain - - - 0.00000000000000000001256 96.0
HKD2_k127_4109211_9 Nucleotidyltransferase domain K07076 - - 0.0000000000000000002253 91.0
HKD2_k127_4110512_0 Aconitase C-terminal domain K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000439 595.0
HKD2_k127_4110512_1 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 374.0
HKD2_k127_4110512_2 protein transport across the cell outer membrane K02452,K02463 - - 0.00000000000000000000000000000000471 139.0
HKD2_k127_4110512_3 4Fe-4S single cluster domain of Ferredoxin I K05337 - - 0.000000000000001725 78.0
HKD2_k127_4123060_0 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008381 489.0
HKD2_k127_4123060_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 446.0
HKD2_k127_4123060_10 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000000003042 132.0
HKD2_k127_4123060_11 low-complexity proteins - - - 0.00000000000000000000003599 108.0
HKD2_k127_4123060_12 response regulator receiver K02658 - - 0.0000000000000000002976 100.0
HKD2_k127_4123060_13 CrcB-like protein, Camphor Resistance (CrcB) K06199 - - 0.0000000004652 61.0
HKD2_k127_4123060_2 MoeA C-terminal region (domain IV) K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007385 427.0
HKD2_k127_4123060_3 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 396.0
HKD2_k127_4123060_4 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000596 315.0
HKD2_k127_4123060_5 Permease K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002 278.0
HKD2_k127_4123060_6 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000009379 243.0
HKD2_k127_4123060_7 Uncharacterized ACR, COG1993 K09137 - - 0.00000000000000000000000000000000000000000000000000001435 196.0
HKD2_k127_4123060_8 Zinc dependent phospholipase C - - - 0.0000000000000000000000000000000000000000000000000000448 195.0
HKD2_k127_4123060_9 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.00000000000000000000000000000000000000000000000001231 190.0
HKD2_k127_4148376_0 PFAM Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 318.0
HKD2_k127_4148376_1 EVE domain - - - 0.00000000000000000000000000000000000000000000000000007244 189.0
HKD2_k127_4152149_0 PFAM V-type ATPase 116 kDa K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 528.0
HKD2_k127_4152149_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 419.0
HKD2_k127_4152149_2 Rhomboid family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000124 248.0
HKD2_k127_4152149_3 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000000001558 68.0
HKD2_k127_4218330_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 458.0
HKD2_k127_4218330_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 408.0
HKD2_k127_4218330_10 Protein of unknown function, DUF488 - - - 0.00003872 46.0
HKD2_k127_4218330_2 Di-iron-containing protein involved in the repair of iron-sulfur clusters K07322 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 341.0
HKD2_k127_4218330_3 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000000135 240.0
HKD2_k127_4218330_4 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000005583 223.0
HKD2_k127_4218330_5 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000000000125 185.0
HKD2_k127_4218330_6 Molecular chaperone. Has ATPase activity K04079 - - 0.00000000000000000000000000000000000000000000000004579 181.0
HKD2_k127_4218330_7 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000005431 158.0
HKD2_k127_4218330_8 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.000000000000000000000000000000000000003723 147.0
HKD2_k127_4218330_9 HDOD domain - - - 0.000000005269 61.0
HKD2_k127_4234282_0 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003518 508.0
HKD2_k127_4234282_1 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000356 247.0
HKD2_k127_4234282_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000006759 104.0
HKD2_k127_4304466_0 phosphorelay sensor kinase activity K03320,K03407 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 398.0
HKD2_k127_4304466_1 Branched-chain amino acid transport system / permease component K01997 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 372.0
HKD2_k127_4304466_2 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002881 318.0
HKD2_k127_4304466_3 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006991 312.0
HKD2_k127_4304466_4 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005532 291.0
HKD2_k127_4304466_5 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004666 279.0
HKD2_k127_4304466_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003384 274.0
HKD2_k127_4304466_7 GDP-mannose mannosyl hydrolase activity - - - 0.000000000000000000000008626 102.0
HKD2_k127_4304466_8 DNA restriction-modification system - GO:0000737,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006304,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009036,GO:0009056,GO:0009057,GO:0009307,GO:0009987,GO:0015666,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044355,GO:0046483,GO:0046700,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0099046,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.000007112 48.0
HKD2_k127_4304466_9 DNA recombination protein RmuC homolog K09760 - - 0.00009374 51.0
HKD2_k127_4320686_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 7.882e-233 728.0
HKD2_k127_4320686_1 GAF domain K02584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 525.0
HKD2_k127_4320686_10 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.00005899 51.0
HKD2_k127_4320686_2 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 506.0
HKD2_k127_4320686_3 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000009813 229.0
HKD2_k127_4320686_4 Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000000000000000000000000006235 214.0
HKD2_k127_4320686_5 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000599 190.0
HKD2_k127_4320686_6 Belongs to the Fur family K03711,K09825 - - 0.000000000000000000000000000000000000000000000003782 175.0
HKD2_k127_4320686_7 GYD domain - - - 0.00000000000000000000000000000000000000004313 153.0
HKD2_k127_4320686_8 AhpC/TSA family K03386 - 1.11.1.15 0.0000000000000000000981 89.0
HKD2_k127_4320686_9 peptidyl-tyrosine sulfation - - - 0.00000001459 68.0
HKD2_k127_4349661_0 response regulator receiver K03407,K13490 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 618.0
HKD2_k127_4349661_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003511 356.0
HKD2_k127_4349661_2 histidine kinase HAMP region domain protein K03406,K13487 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001399 346.0
HKD2_k127_4349661_3 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008736 327.0
HKD2_k127_4349661_4 response regulator, receiver - - - 0.0000000000000002027 86.0
HKD2_k127_4349661_5 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.00003995 50.0
HKD2_k127_437526_0 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 518.0
HKD2_k127_437526_1 Bacterial Ig-like domain 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000651 262.0
HKD2_k127_437526_11 general secretion pathway protein K02456,K02457,K02458,K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.00000003955 60.0
HKD2_k127_437526_12 PFAM General secretion pathway protein K K02460 - - 0.000018 56.0
HKD2_k127_437526_2 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 0.00000000000000000000000000000000000000000000000000000000000001573 225.0
HKD2_k127_437526_3 chlorophyll binding K03286,K07275 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000004854 199.0
HKD2_k127_437526_4 PFAM short chain dehydrogenase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000008243 188.0
HKD2_k127_437526_5 Type II secretion system (T2SS), protein J K02459 - - 0.0000000000000000000000004694 113.0
HKD2_k127_437526_7 protein import K01179 - 3.2.1.4 0.000000000000003959 87.0
HKD2_k127_437526_8 - - - - 0.000000000002682 77.0
HKD2_k127_437526_9 - - - - 0.000000002898 65.0
HKD2_k127_4553057_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 3.28e-234 743.0
HKD2_k127_4553057_1 TIGRFAM Hopanoid biosynthesis associated RND transporter like protein HpnN K07003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000985 432.0
HKD2_k127_4553057_2 PFAM VacJ family lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000000000006724 237.0
HKD2_k127_4553057_3 NUDIX domain K01823 - 5.3.3.2 0.00000000000000000000000000000000000000001857 158.0
HKD2_k127_4553057_4 PFAM Toluene tolerance K07323 - - 0.000000000000000000000000000000000001064 147.0
HKD2_k127_4575827_0 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 616.0
HKD2_k127_4575827_1 Uroporphyrinogen decarboxylase (URO-D) K14080 - 2.1.1.246 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006558 444.0
HKD2_k127_4575827_2 Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007392 387.0
HKD2_k127_4575827_3 Methionine synthase, cobalamin (vitamin B12)-binding module, cap - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 329.0
HKD2_k127_4575827_4 TIGRFAM iron-sulfur cluster binding protein - - - 0.00000000000000000000000000000000000000000001588 169.0
HKD2_k127_4575827_5 PFAM Carboxymuconolactone decarboxylase - - - 0.0000002114 52.0
HKD2_k127_465101_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005723 471.0
HKD2_k127_465101_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006785 416.0
HKD2_k127_465101_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 431.0
HKD2_k127_465101_3 Response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002806 403.0
HKD2_k127_465101_4 NMT1/THI5 like K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007911 341.0
HKD2_k127_465101_5 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005742 340.0
HKD2_k127_465101_6 signal transduction histidine kinase K03406 - - 0.000000000000000000000000000000000000000000000000000000000001321 239.0
HKD2_k127_465101_7 cheY-homologous receiver domain - - - 0.000000000000000000000000000000000000000000000000000000002992 203.0
HKD2_k127_465101_8 response regulator, receiver - - - 0.00000000000000000000000000000000000000004229 176.0
HKD2_k127_465101_9 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000598 151.0
HKD2_k127_4663581_0 Mur ligase, middle domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000917 345.0
HKD2_k127_4663581_1 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000181 270.0
HKD2_k127_4663581_2 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000000003273 161.0
HKD2_k127_4663581_3 ROK family K00845 GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135 2.7.1.2 0.000002326 51.0
HKD2_k127_4717051_0 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 541.0
HKD2_k127_4717051_1 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000000000006255 141.0
HKD2_k127_4773496_0 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 389.0
HKD2_k127_4773496_2 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000000000000004398 234.0
HKD2_k127_4773496_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000000004893 229.0
HKD2_k127_4773496_4 2 iron, 2 sulfur cluster binding K01465,K02823,K05784,K17828 - 1.3.1.14,3.5.2.3 0.00000000000000000000000000000000000000000000000000000001057 207.0
HKD2_k127_4773496_5 Cyclic nucleotide-monophosphate binding domain K10914 - - 0.000000000000000000000000000000000000000000000000001252 191.0
HKD2_k127_4773496_6 Putative regulatory protein - - - 0.00000001996 57.0
HKD2_k127_4773496_7 Regulatory protein, FmdB family - - - 0.00000006439 56.0
HKD2_k127_488881_0 PFAM AICARFT IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 4.693e-197 621.0
HKD2_k127_488881_1 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 371.0
HKD2_k127_488881_2 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 363.0
HKD2_k127_488881_3 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 314.0
HKD2_k127_488881_4 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004223 301.0
HKD2_k127_488881_5 Histidine kinase - - - 0.000000000000000000000000000000000000000004426 173.0
HKD2_k127_488881_6 HAMP domain - - - 0.00000000000000000000000000007666 132.0
HKD2_k127_488881_7 Thioredoxin K03672 - 1.8.1.8 0.000000000000000000000246 102.0
HKD2_k127_488881_8 Protein of unknown function (DUF1189) - - - 0.0000000000000002763 88.0
HKD2_k127_492028_0 Protein of unknown function (DUF3373) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 512.0
HKD2_k127_492028_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 323.0
HKD2_k127_492028_10 peptidyl-tyrosine sulfation - - - 0.00000000006222 75.0
HKD2_k127_492028_12 PFAM sigma-54 factor interaction domain-containing protein K02584 - - 0.000000009261 61.0
HKD2_k127_492028_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004087 323.0
HKD2_k127_492028_3 Alcohol dehydrogenase GroES-like domain K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000003159 228.0
HKD2_k127_492028_4 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000000000000007233 203.0
HKD2_k127_492028_5 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.00000000000000000000000000000000000000000000000008443 184.0
HKD2_k127_492028_6 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000000009996 171.0
HKD2_k127_492028_7 - - - - 0.0000000000000000000000000000000000000000107 164.0
HKD2_k127_492028_8 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000000000000000000002225 166.0
HKD2_k127_492028_9 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000002336 97.0
HKD2_k127_4982303_0 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000125 227.0
HKD2_k127_4982303_1 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000000000000001597 176.0
HKD2_k127_4982303_2 SMART HNH nuclease K07451 - - 0.000000000000000000000000000000000000008382 148.0
HKD2_k127_4982303_3 Protein of unknown function (DUF507) - - - 0.0000000000000000000000000001546 116.0
HKD2_k127_4982303_4 Protein of unknown function (DUF507) - - - 0.00000000000000000000000002467 111.0
HKD2_k127_4982303_5 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000006028 96.0
HKD2_k127_4982303_6 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000008193 71.0
HKD2_k127_5068405_0 hmm pf00545 - GO:0005575,GO:0005576 - 0.000000000000000000000000000000000000000000000000001356 186.0
HKD2_k127_5068405_1 photosystem II stabilization K02237 - - 0.0000000000000000000000000000000001215 141.0
HKD2_k127_5068405_2 Barstar (barnase inhibitor) K03623 - - 0.000000000000000805 80.0
HKD2_k127_5068405_3 PPIC-type PPIASE domain K03769,K03770 - 5.2.1.8 0.0000271 53.0
HKD2_k127_5068405_4 response regulator containing a CheY-like receiver domain and a GGDEF domain K02488 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 0.000928 50.0
HKD2_k127_5114417_0 COG0463 Glycosyltransferases involved in cell wall biogenesis K13693 - 2.4.1.266 2.939e-204 642.0
HKD2_k127_5114417_1 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 446.0
HKD2_k127_5114417_2 haloacid dehalogenase-like hydrolase K07026 - 3.1.3.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 320.0
HKD2_k127_5114417_3 ATP synthase subunit D K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002265 261.0
HKD2_k127_5114417_4 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000005986 138.0
HKD2_k127_5114417_5 PBS lyase HEAT domain protein repeat-containing protein - - - 0.00000001839 64.0
HKD2_k127_5123597_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 3.797e-315 972.0
HKD2_k127_5123597_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 9.116e-246 770.0
HKD2_k127_5123597_2 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 501.0
HKD2_k127_5123597_3 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 436.0
HKD2_k127_5123597_4 PFAM DAHP synthetase I KDSA K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007728 364.0
HKD2_k127_5123597_5 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000009615 250.0
HKD2_k127_5123597_6 Peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000002406 201.0
HKD2_k127_5135246_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 9.289e-277 863.0
HKD2_k127_5135246_1 Chemoreceptor zinc-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008048 242.0
HKD2_k127_5135246_2 Cation efflux family - - - 0.000003079 51.0
HKD2_k127_51593_0 TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit K00198 - 1.2.7.4 3.874e-265 831.0
HKD2_k127_51593_1 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 456.0
HKD2_k127_51593_2 Pyridine nucleotide-disulphide oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 304.0
HKD2_k127_51593_3 Cache domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001299 229.0
HKD2_k127_51593_4 4Fe-4S dicluster domain K00196 - - 0.0000000000000000000000000000000000000000000000003388 181.0
HKD2_k127_51593_5 - - - - 0.000000000005245 74.0
HKD2_k127_5173595_0 Sigma-54 interaction domain - - - 6.553e-218 683.0
HKD2_k127_5173595_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 441.0
HKD2_k127_5173595_2 TIGRFAM Methylglyoxal synthase K01734 - 4.2.3.3 0.00000000000000000000000000000000000000000001411 162.0
HKD2_k127_5173595_3 PFAM Auxin Efflux Carrier K07088 - - 0.00000000000000000000000000000000000000002734 164.0
HKD2_k127_5173595_4 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.00000004086 57.0
HKD2_k127_5181026_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004969 449.0
HKD2_k127_5181026_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 390.0
HKD2_k127_5181026_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 337.0
HKD2_k127_5221529_0 AMP-binding enzyme C-terminal domain - - - 1.77e-211 674.0
HKD2_k127_5221529_1 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 567.0
HKD2_k127_5221529_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000748 563.0
HKD2_k127_5221529_3 HlyD family secretion protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004014 482.0
HKD2_k127_5221529_4 Belongs to the TPP enzyme family K01577 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0008150,GO:0008152,GO:0008949,GO:0009056,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017076,GO:0019752,GO:0019842,GO:0030554,GO:0030976,GO:0032553,GO:0032555,GO:0032559,GO:0033609,GO:0033611,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043531,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0071704,GO:0097159,GO:0097367,GO:0104004,GO:1901265,GO:1901363,GO:1901575,GO:1901681 4.1.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009353 452.0
HKD2_k127_5221529_5 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 353.0
HKD2_k127_5221529_6 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - - 0.00000000000000000000000000000000000000000000000000000001099 200.0
HKD2_k127_5242549_0 Domains REC, sigma54 interaction, HTH8 K02481 - - 6.608e-201 636.0
HKD2_k127_5242549_1 PFAM UBA THIF-type NAD FAD binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 294.0
HKD2_k127_5242549_2 Signal transduction histidine kinase - - - 0.0000000000000002142 79.0
HKD2_k127_5255901_0 MMPL family K07003 - - 3.011e-294 924.0
HKD2_k127_5255901_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.42e-292 910.0
HKD2_k127_5255901_10 Receptor - - - 0.0000002574 57.0
HKD2_k127_5255901_11 sulfur relay protein TusB DsrH K07237 - - 0.00000436 52.0
HKD2_k127_5255901_12 PFAM DsrE family protein K06039,K07235 - - 0.0000156 51.0
HKD2_k127_5255901_2 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 5.271e-243 773.0
HKD2_k127_5255901_3 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 480.0
HKD2_k127_5255901_4 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 399.0
HKD2_k127_5255901_5 Outer membrane lipoprotein-sorting protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001619 229.0
HKD2_k127_5255901_6 DNA-binding transcription factor activity K03655,K03892,K21903 - 3.6.4.12 0.00000000000000000000002128 104.0
HKD2_k127_5255901_7 YtxH-like protein - - - 0.00000000000000000004118 98.0
HKD2_k127_5255901_8 - - - - 0.0000000000000001785 82.0
HKD2_k127_5257089_0 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007924 269.0
HKD2_k127_5257089_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000006485 265.0
HKD2_k127_5257089_2 membrane K07058 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000468 70.0
HKD2_k127_5262039_0 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006875 418.0
HKD2_k127_5262039_1 Serine aminopeptidase, S33 K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001823 274.0
HKD2_k127_5276442_0 Protein of unknown function (DUF512) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 419.0
HKD2_k127_5276442_1 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000003383 220.0
HKD2_k127_5276442_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.0000000000000000000000000000000002034 138.0
HKD2_k127_5323580_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007002 524.0
HKD2_k127_5323580_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006474 420.0
HKD2_k127_5323580_2 Protein of unknown function (DUF1385) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 317.0
HKD2_k127_5323580_3 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000000000001682 258.0
HKD2_k127_5323580_4 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000001339 173.0
HKD2_k127_5323580_5 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000002035 171.0
HKD2_k127_5323580_6 Binds the 23S rRNA K02909 - - 0.00000000000000000000000000002266 117.0
HKD2_k127_5323580_7 UPF0761 membrane protein K07058 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000001413 81.0
HKD2_k127_5331652_0 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000702 307.0
HKD2_k127_5331652_1 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000000000000000699 202.0
HKD2_k127_5356790_0 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 0.0 1073.0
HKD2_k127_5356790_1 Phosphoglycerate kinase K00927 - 2.7.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008806 601.0
HKD2_k127_5356790_10 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000001326 227.0
HKD2_k127_5356790_11 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000005442 216.0
HKD2_k127_5356790_12 Protein of unknown function (DUF2844) - - - 0.0000000000000000000000000000000000000000000000001898 181.0
HKD2_k127_5356790_13 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000005806 185.0
HKD2_k127_5356790_15 AsmA-like C-terminal region K07289 - - 0.0000000000000000000000000000000000000004282 168.0
HKD2_k127_5356790_16 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000003865 151.0
HKD2_k127_5356790_18 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000001266 100.0
HKD2_k127_5356790_19 - - - - 0.000000000000000000006195 97.0
HKD2_k127_5356790_2 FecR protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004787 452.0
HKD2_k127_5356790_20 - - - - 0.00000000000000000004505 91.0
HKD2_k127_5356790_22 protein secretion K03116,K03117 - - 0.000000000000003879 78.0
HKD2_k127_5356790_23 Response regulator, receiver - - - 0.00000003305 66.0
HKD2_k127_5356790_24 transferase activity, transferring glycosyl groups - - - 0.000000101 59.0
HKD2_k127_5356790_3 Protein of unknown function (DUF3443) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 430.0
HKD2_k127_5356790_4 Histidine kinase A domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 404.0
HKD2_k127_5356790_5 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 357.0
HKD2_k127_5356790_6 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003869 375.0
HKD2_k127_5356790_7 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 318.0
HKD2_k127_5356790_8 COG2195 Di- and tripeptidases K01258 - 3.4.11.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001386 292.0
HKD2_k127_5356790_9 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001212 258.0
HKD2_k127_5365341_0 Glycosyl hydrolase family 57 - - - 5.722e-225 718.0
HKD2_k127_5365341_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006376 574.0
HKD2_k127_5365341_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 479.0
HKD2_k127_5365341_3 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000002254 141.0
HKD2_k127_5365341_4 - - - - 0.0000000000000000000000004029 120.0
HKD2_k127_5365341_5 cell cycle K05589,K12065,K13052 - - 0.00000000000000003315 85.0
HKD2_k127_5365341_6 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000004418 81.0
HKD2_k127_5365341_7 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.000007943 48.0
HKD2_k127_5367527_0 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 368.0
HKD2_k127_5367527_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 289.0
HKD2_k127_5367527_2 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000002609 265.0
HKD2_k127_5367527_3 Heptaprenyl diphosphate synthase component I K00805 - 2.5.1.30 0.000000000000000000000000000000001825 136.0
HKD2_k127_5367527_4 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.000000000000000001448 86.0
HKD2_k127_5367527_5 NusG domain II K00805 - 2.5.1.30 0.000000000000001783 81.0
HKD2_k127_5367527_6 PFAM Radical SAM - - - 0.0000000000004626 80.0
HKD2_k127_5382048_0 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008336 505.0
HKD2_k127_5382048_1 Alpha beta hydrolase superfamily K01563 - 3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006213 396.0
HKD2_k127_5382048_2 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001584 303.0
HKD2_k127_5382048_3 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007565 287.0
HKD2_k127_5382048_4 Stage II sporulation protein E (SpoIIE) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001223 255.0
HKD2_k127_5382048_6 Belongs to the HesB IscA family K15724 - - 0.0000000000000000000000000001378 117.0
HKD2_k127_5382048_7 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.000000000000000000001901 98.0
HKD2_k127_5382048_8 STAS domain K04749 - - 0.000000000000000000003122 96.0
HKD2_k127_5386217_0 SMART Elongator protein 3 MiaB NifB - - - 6.039e-210 681.0
HKD2_k127_5386217_1 FAD binding domain K00278 - 1.4.3.16 8.575e-205 649.0
HKD2_k127_5386217_10 Tetratricopeptide repeat K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002578 252.0
HKD2_k127_5386217_11 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000004374 214.0
HKD2_k127_5386217_12 - - - - 0.000000000000000000000000000000000000000000000000003833 185.0
HKD2_k127_5386217_13 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000003425 190.0
HKD2_k127_5386217_14 TIGRFAM siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000000000000309 169.0
HKD2_k127_5386217_15 nucleotide metabolic process - - - 0.00000000000000000000000000000000004368 144.0
HKD2_k127_5386217_16 Belongs to the universal stress protein A family - - - 0.000000000000000000002553 99.0
HKD2_k127_5386217_17 4Fe-4S binding domain - - - 0.000000000000002177 79.0
HKD2_k127_5386217_18 Chemotaxis phosphatase CheX - - - 0.000000000000004194 79.0
HKD2_k127_5386217_19 peptidyl-tyrosine sulfation - - - 0.0000000008459 68.0
HKD2_k127_5386217_2 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007837 590.0
HKD2_k127_5386217_20 Belongs to the sulfur carrier protein TusA family - - - 0.00000000279 61.0
HKD2_k127_5386217_21 DsrE/DsrF-like family K07235 - - 0.0000001141 58.0
HKD2_k127_5386217_22 acetyltransferases and hydrolases with the alpha beta hydrolase fold K01046 - 3.1.1.3 0.0004865 51.0
HKD2_k127_5386217_23 DsrE/DsrF-like family K07236 - - 0.0006629 48.0
HKD2_k127_5386217_25 sulfur relay protein TusB DsrH K07237 - - 0.0009967 46.0
HKD2_k127_5386217_3 2Fe-2S iron-sulfur cluster binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 559.0
HKD2_k127_5386217_4 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009566 417.0
HKD2_k127_5386217_5 PFAM histone deacetylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 363.0
HKD2_k127_5386217_6 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 337.0
HKD2_k127_5386217_7 serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009862 320.0
HKD2_k127_5386217_8 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 302.0
HKD2_k127_5386217_9 PFAM PP-loop domain protein K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005978 274.0
HKD2_k127_5390397_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 8.153e-203 635.0
HKD2_k127_5390397_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 1.192e-200 632.0
HKD2_k127_5390397_10 Pfam:Arch_ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000708 269.0
HKD2_k127_5390397_11 HEAT repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002844 277.0
HKD2_k127_5390397_12 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000001512 248.0
HKD2_k127_5390397_13 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.00000000000000000000000000000000000000000000000000005207 189.0
HKD2_k127_5390397_14 Thioredoxin-like domain K03671 - - 0.0000000000000000000000000000000000000000000000001021 179.0
HKD2_k127_5390397_15 Response regulator receiver domain K03413 - - 0.0000000000000000000000000000000000000000000001393 170.0
HKD2_k127_5390397_16 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000009191 157.0
HKD2_k127_5390397_17 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.0000000000000000000000000000000000000003737 172.0
HKD2_k127_5390397_18 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000001542 153.0
HKD2_k127_5390397_19 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 0.0000000000000000000000000000000000001126 149.0
HKD2_k127_5390397_2 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 499.0
HKD2_k127_5390397_20 cell redox homeostasis K02199 - - 0.0000000000000000000000000000000000003934 148.0
HKD2_k127_5390397_21 PFAM response regulator receiver K03413 - - 0.000000000000000000000000000000000001719 141.0
HKD2_k127_5390397_22 Belongs to the UPF0109 family K06960 - - 0.0000000000000000000000000000000002519 133.0
HKD2_k127_5390397_23 Chemotaxis protein CheW K03408 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006935,GO:0008150,GO:0009453,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0042333,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - 0.00000000000000000000000000000001681 131.0
HKD2_k127_5390397_24 regulator, PATAN and FRGAF domain-containing - - - 0.0000000000000000000000000000001422 138.0
HKD2_k127_5390397_25 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000005158 108.0
HKD2_k127_5390397_26 PFAM CheW domain protein K03408 - - 0.00000000000000000000008527 108.0
HKD2_k127_5390397_3 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 391.0
HKD2_k127_5390397_4 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 356.0
HKD2_k127_5390397_5 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007829 334.0
HKD2_k127_5390397_6 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 317.0
HKD2_k127_5390397_7 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000023 318.0
HKD2_k127_5390397_8 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001426 285.0
HKD2_k127_5390397_9 CO dehydrogenase K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001324 284.0
HKD2_k127_5432104_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 447.0
HKD2_k127_5432104_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 348.0
HKD2_k127_5432104_2 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 327.0
HKD2_k127_5432104_3 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 315.0
HKD2_k127_5470193_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 483.0
HKD2_k127_5470193_1 Oxidoreductase FAD-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 415.0
HKD2_k127_5470193_2 coenzyme F420 hydrogenase activity K14128 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 407.0
HKD2_k127_5470193_3 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000003037 266.0
HKD2_k127_5470193_4 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.000000000000000000000000000000000000000000000000005717 185.0
HKD2_k127_5470193_5 Nickel-dependent hydrogenase - - - 0.00000000000000000000000000000002038 127.0
HKD2_k127_5588907_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2112.0
HKD2_k127_5588907_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1941.0
HKD2_k127_5588907_10 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001173 268.0
HKD2_k127_5588907_11 Mo-molybdopterin cofactor metabolic process K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003809 262.0
HKD2_k127_5588907_12 General secretory system II, protein E domain protein K02652 - - 0.00000000000000000000000000000000000000000000000000000000000003635 216.0
HKD2_k127_5588907_13 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000000002605 213.0
HKD2_k127_5588907_14 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000000000000001127 185.0
HKD2_k127_5588907_15 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000188 147.0
HKD2_k127_5588907_16 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358,K15771 GO:0001666,GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009274,GO:0009275,GO:0009628,GO:0009986,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010339,GO:0010467,GO:0016020,GO:0019538,GO:0019899,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0034641,GO:0034645,GO:0035375,GO:0035821,GO:0036293,GO:0040007,GO:0042221,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044444,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0070482,GO:0071704,GO:0071944,GO:0090087,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484 - 0.000000000000000000000000000000000002291 138.0
HKD2_k127_5588907_17 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000000004064 136.0
HKD2_k127_5588907_18 structural constituent of ribosome K02913 - - 0.000000000000001496 78.0
HKD2_k127_5588907_19 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000002593 79.0
HKD2_k127_5588907_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 2.85e-216 679.0
HKD2_k127_5588907_20 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000255 71.0
HKD2_k127_5588907_3 twitching motility protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008906 530.0
HKD2_k127_5588907_4 response regulator K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 469.0
HKD2_k127_5588907_5 TrkA-N domain K03455,K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 366.0
HKD2_k127_5588907_6 Type II secretion system (T2SS), protein F K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 355.0
HKD2_k127_5588907_7 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 338.0
HKD2_k127_5588907_8 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 314.0
HKD2_k127_5588907_9 His Kinase A (phosphoacceptor) domain K02668,K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 306.0
HKD2_k127_5611168_0 Elongation factor G, domain IV K02355 - - 1.009e-310 966.0
HKD2_k127_5640429_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 4.28e-239 752.0
HKD2_k127_5640429_1 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 558.0
HKD2_k127_5640429_2 OsmC-like protein K04063 - - 0.000000000000000000000000000000000000000000000000007544 184.0
HKD2_k127_5640429_3 Belongs to the acetyltransferase family. ArgA subfamily K00619,K14681 GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.00000000000000001791 81.0
HKD2_k127_5656222_0 Histidine kinase - - - 5.643e-204 669.0
HKD2_k127_5656222_1 HD domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 292.0
HKD2_k127_5656222_2 oxidoreductase K10960 - 1.3.1.111,1.3.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004737 286.0
HKD2_k127_5656222_3 energy transducer activity K03832 - - 0.00000000000000000000000000000000000000000001827 172.0
HKD2_k127_5656222_4 Universal stress protein family - - - 0.000000000000000000000000000000000000000154 154.0
HKD2_k127_5656222_5 proteolysis K03665 - - 0.00000000000000000000000000000002759 132.0
HKD2_k127_5656222_6 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 - 2.1.1.63 0.00000000000000000000000000001598 125.0
HKD2_k127_5656222_7 - - - - 0.00000000000000000000000000002156 117.0
HKD2_k127_5656222_8 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000001036 53.0
HKD2_k127_5664099_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007703 412.0
HKD2_k127_5664099_1 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000161 215.0
HKD2_k127_5664099_2 Rhodanese Homology Domain - - - 0.0000000000000008718 79.0
HKD2_k127_567025_0 PFAM Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 503.0
HKD2_k127_567025_1 PFAM 4Fe-4S K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007864 438.0
HKD2_k127_567025_2 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 336.0
HKD2_k127_567025_3 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000001366 205.0
HKD2_k127_567025_4 Cytochrome c - - - 0.00000000000000000000000000000000000000000000001124 172.0
HKD2_k127_567025_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000005647 172.0
HKD2_k127_567025_6 Protein of unknown function (DUF3795) - - - 0.000000000000000000000000000000001551 133.0
HKD2_k127_567025_7 PFAM Rieske 2Fe-2S K02636 - 1.10.9.1 0.00000000000000000000000000005161 120.0
HKD2_k127_5716234_0 COG0058 Glucan phosphorylase - - - 1.121e-255 799.0
HKD2_k127_5716234_1 Acetyl-CoA acetyltransferase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002463 441.0
HKD2_k127_5716234_2 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 402.0
HKD2_k127_5716234_3 3-hydroxyacyl-CoA dehydrogenase K00074,K01782 - 1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007499 373.0
HKD2_k127_5716234_4 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 356.0
HKD2_k127_5716234_5 Amino acid kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009119 322.0
HKD2_k127_5716234_6 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 307.0
HKD2_k127_5716234_7 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000003024 257.0
HKD2_k127_5716234_8 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.0000000000000000000000000002232 118.0
HKD2_k127_5720450_0 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000139 258.0
HKD2_k127_5720450_1 Formylmethanofuran dehydrogenase, subunit e K11261 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000116 238.0
HKD2_k127_5720450_2 von Willebrand factor type A domain - - - 0.0000000000000000000000000000000000000000000001939 184.0
HKD2_k127_5729365_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 5.022e-274 858.0
HKD2_k127_5729365_1 Protein of unknown function, DUF255 K06888 - - 3.08e-241 763.0
HKD2_k127_5729365_10 SNARE associated Golgi protein K03975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 328.0
HKD2_k127_5729365_11 Carbon-nitrogen hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 309.0
HKD2_k127_5729365_12 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005876 307.0
HKD2_k127_5729365_13 tRNA (Guanine-1)-methyltransferase K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009599 282.0
HKD2_k127_5729365_14 DJ-1/PfpI family K03152,K05520,K05687 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000000000009094 248.0
HKD2_k127_5729365_15 ferroxidase activity K03594 GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000002629 235.0
HKD2_k127_5729365_16 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000048 222.0
HKD2_k127_5729365_17 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000001253 221.0
HKD2_k127_5729365_18 PFAM iron dependent repressor K03709 - - 0.000000000000000000000000000000000000000000000000000000002008 206.0
HKD2_k127_5729365_19 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000000008748 189.0
HKD2_k127_5729365_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.739e-226 709.0
HKD2_k127_5729365_20 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED K07025 - - 0.00000000000000000000000000000000000000000000000002715 185.0
HKD2_k127_5729365_21 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000000000000000001016 171.0
HKD2_k127_5729365_23 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000007324 158.0
HKD2_k127_5729365_24 Type III restriction enzyme res subunit K01156 - 3.1.21.5 0.0000000000000000000000000000000000004065 143.0
HKD2_k127_5729365_25 Cytochrome P460 - - - 0.00000000000000000000000000000000004359 141.0
HKD2_k127_5729365_26 electron transfer activity K00428 - 1.11.1.5 0.00000000000000000000000002499 112.0
HKD2_k127_5729365_27 Protein of unknown function (DUF2283) - - - 0.0000000000000000004768 90.0
HKD2_k127_5729365_28 - - - - 0.0000000000005864 70.0
HKD2_k127_5729365_29 Protein of unknown function (DUF433) - - - 0.0000000000006593 71.0
HKD2_k127_5729365_3 AMP-binding enzyme C-terminal domain K05939 - 2.3.1.40,6.2.1.20 5.017e-210 663.0
HKD2_k127_5729365_30 Mut7-C RNAse domain - - - 0.000000009875 63.0
HKD2_k127_5729365_31 HicA toxin of bacterial toxin-antitoxin, - - - 0.00000006915 55.0
HKD2_k127_5729365_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 2.111e-202 636.0
HKD2_k127_5729365_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 5.705e-198 629.0
HKD2_k127_5729365_6 PFAM natural resistance-associated macrophage protein K03322 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 531.0
HKD2_k127_5729365_7 Outer membrane protein transport protein (OMPP1/FadL/TodX) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003763 466.0
HKD2_k127_5729365_8 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003853 395.0
HKD2_k127_5729365_9 COG1194 A G-specific DNA glycosylase K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 332.0
HKD2_k127_5838200_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002415 321.0
HKD2_k127_5838200_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000009527 224.0
HKD2_k127_5838200_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000002339 187.0
HKD2_k127_5838200_3 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000004639 154.0
HKD2_k127_5838200_4 Ribosomal protein L35 K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000009777 87.0
HKD2_k127_5913339_0 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009531 406.0
HKD2_k127_5913339_1 CHASE2 K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006004 312.0
HKD2_k127_5913339_2 CoA binding domain K09181 - - 0.0000000000000000000000000000000000000000000000000000000000003517 216.0
HKD2_k127_5913339_3 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000001878 93.0
HKD2_k127_5926467_0 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 514.0
HKD2_k127_5926467_1 PFAM glycosyl transferase, family 9 K02841 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004705 355.0
HKD2_k127_5926467_2 Cytochrome c554 and c-prime - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001135 250.0
HKD2_k127_5926467_3 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000005294 231.0
HKD2_k127_5926467_4 protein-disulfide reductase activity - - - 0.000000000000000000000000007647 115.0
HKD2_k127_5926467_5 - - - - 0.00000000000000000000000002377 111.0
HKD2_k127_5926467_6 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000001985 82.0
HKD2_k127_5958308_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1185.0
HKD2_k127_5958308_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 1.027e-282 900.0
HKD2_k127_5958308_10 LemA family K03744 - - 0.00000000000000000000000000001421 125.0
HKD2_k127_5958308_11 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.000000000000000000001561 99.0
HKD2_k127_5958308_12 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.0000000000000961 71.0
HKD2_k127_5958308_13 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000004374 74.0
HKD2_k127_5958308_2 fatty acid beta-oxidation using acyl-CoA dehydrogenase K03522,K22432 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.3.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003986 511.0
HKD2_k127_5958308_3 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 465.0
HKD2_k127_5958308_4 Nucleotidyl transferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 370.0
HKD2_k127_5958308_5 malonyl coa-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 347.0
HKD2_k127_5958308_6 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 343.0
HKD2_k127_5958308_7 Electron transfer flavoprotein K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 329.0
HKD2_k127_5958308_8 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000001331 234.0
HKD2_k127_5958308_9 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000005066 220.0
HKD2_k127_6057083_0 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 413.0
HKD2_k127_6057083_1 phosphatase activity K20881 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001046 283.0
HKD2_k127_6057083_2 inositol monophosphate 1-phosphatase activity K01082,K01092 - 3.1.3.25,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000002361 211.0
HKD2_k127_6057083_3 Protein of unknown function (DUF1284) K09706 - - 0.0000000000000000000000000000000002234 136.0
HKD2_k127_6057083_4 electron transfer activity K05337,K17247 - - 0.000000000000000000000000001978 111.0
HKD2_k127_6057083_5 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000211 112.0
HKD2_k127_6120590_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 503.0
HKD2_k127_6120590_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 503.0
HKD2_k127_6120590_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005954 402.0
HKD2_k127_6120590_3 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007688 291.0
HKD2_k127_61740_0 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 5.277e-269 854.0
HKD2_k127_61740_1 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009438 469.0
HKD2_k127_61740_10 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000001736 181.0
HKD2_k127_61740_11 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458,K14660 - 2.3.1.179 0.00000000000000000000000000000000000000000000374 166.0
HKD2_k127_61740_12 DNA polymerase X family K02347 - - 0.00000000000000000000000000000000000000000001152 164.0
HKD2_k127_61740_13 Lipid A biosynthesis K02517 - 2.3.1.241 0.000000000000000000000000000000000000127 153.0
HKD2_k127_61740_14 FabA-like domain K02372 - 4.2.1.59 0.00000000000000000000003728 104.0
HKD2_k127_61740_15 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000001355 96.0
HKD2_k127_61740_16 Glutaredoxin K03676 - - 0.00000000001016 66.0
HKD2_k127_61740_2 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003612 386.0
HKD2_k127_61740_3 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009824 365.0
HKD2_k127_61740_4 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002007 365.0
HKD2_k127_61740_5 diguanylate cyclase K02488 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005956 297.0
HKD2_k127_61740_6 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000009786 261.0
HKD2_k127_61740_7 Methyltransferase K15256 - - 0.0000000000000000000000000000000000000000000000000000000000001201 220.0
HKD2_k127_61740_8 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000002302 208.0
HKD2_k127_61740_9 mRNA catabolic process K06950 - - 0.00000000000000000000000000000000000000000000000000000001564 202.0
HKD2_k127_619500_0 histidine kinase HAMP region domain protein K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000479 309.0
HKD2_k127_619500_1 PFAM natural resistance-associated macrophage protein - - - 0.000000000000000000000000000000000000000000000002204 176.0
HKD2_k127_62152_0 Telomere recombination K04656 - - 2.543e-251 797.0
HKD2_k127_62152_1 CobW/HypB/UreG, nucleotide-binding domain K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004109 323.0
HKD2_k127_62152_2 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 307.0
HKD2_k127_62152_3 YtxH-like protein - - - 0.0000000000000000000000000000000799 127.0
HKD2_k127_62152_4 nickel cation binding K04651,K19640 - - 0.0000000000000000000000000003712 117.0
HKD2_k127_62152_5 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000001012 80.0
HKD2_k127_62152_7 Hydrogenase formation hypA family K04654 - - 0.000000002291 59.0
HKD2_k127_6394901_0 Cytochrome c554 and c-prime - - - 4.186e-243 759.0
HKD2_k127_6394901_1 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 1.603e-209 664.0
HKD2_k127_6394901_10 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.000000000000000000000000000000000003287 144.0
HKD2_k127_6394901_11 - - - - 0.000000000000159 74.0
HKD2_k127_6394901_2 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 580.0
HKD2_k127_6394901_3 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004336 487.0
HKD2_k127_6394901_4 S-adenosylmethionine synthetase (AdoMet synthetase) K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 295.0
HKD2_k127_6394901_5 Lipocalin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 297.0
HKD2_k127_6394901_6 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000005264 235.0
HKD2_k127_6394901_7 - - - - 0.000000000000000000000000000000000000000000000000000000002617 213.0
HKD2_k127_6394901_8 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000004978 175.0
HKD2_k127_6394901_9 Domain of unknown function (DUF3786) - - - 0.000000000000000000000000000000000001114 144.0
HKD2_k127_6398916_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.093e-206 661.0
HKD2_k127_6398916_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.527e-202 647.0
HKD2_k127_6398916_10 His Kinase A (phosphoacceptor) domain K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000002967 265.0
HKD2_k127_6398916_11 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K00067,K01790 - 1.1.1.133,5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000009151 254.0
HKD2_k127_6398916_12 undecaprenyl-phosphate glucose phosphotransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000004771 224.0
HKD2_k127_6398916_13 Transcription termination factor nusG - - - 0.0000000000000000000000000000000000000000000000002042 183.0
HKD2_k127_6398916_14 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.000000000000132 81.0
HKD2_k127_6398916_15 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.000000000005629 73.0
HKD2_k127_6398916_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 587.0
HKD2_k127_6398916_3 Bacterial regulatory protein, Fis family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 567.0
HKD2_k127_6398916_4 Bacterial regulatory protein, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 556.0
HKD2_k127_6398916_5 Cys/Met metabolism PLP-dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005049 525.0
HKD2_k127_6398916_6 epimerase dehydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 514.0
HKD2_k127_6398916_7 Polysaccharide biosynthesis protein CapD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002644 514.0
HKD2_k127_6398916_8 Nucleotidyl transferase K00978 - 2.7.7.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 430.0
HKD2_k127_6398916_9 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006353 314.0
HKD2_k127_6399522_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1254.0
HKD2_k127_6399522_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1123.0
HKD2_k127_6399522_10 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000001404 247.0
HKD2_k127_6399522_11 MlaD protein K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000001036 233.0
HKD2_k127_6399522_12 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000004794 220.0
HKD2_k127_6399522_13 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000000000002074 192.0
HKD2_k127_6399522_14 Belongs to the small heat shock protein (HSP20) family K06335,K13993 GO:0001666,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016310,GO:0019538,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0036294,GO:0040007,GO:0040008,GO:0042221,GO:0042594,GO:0043170,GO:0043207,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045926,GO:0046777,GO:0048519,GO:0050789,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0065007,GO:0070482,GO:0070887,GO:0071453,GO:0071456,GO:0071496,GO:0071704,GO:0071944,GO:0075136,GO:1901564 - 0.00000000000000000000000000000000000000000000009913 175.0
HKD2_k127_6399522_15 lysyltransferase activity K07027 - - 0.000000000000000000000000000000000000000000001335 177.0
HKD2_k127_6399522_16 bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding K13640 GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000693 132.0
HKD2_k127_6399522_17 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000001995 97.0
HKD2_k127_6399522_2 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006685 536.0
HKD2_k127_6399522_3 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004412 513.0
HKD2_k127_6399522_4 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006642 473.0
HKD2_k127_6399522_5 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003397 341.0
HKD2_k127_6399522_6 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 357.0
HKD2_k127_6399522_7 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 319.0
HKD2_k127_6399522_8 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004974 292.0
HKD2_k127_6399522_9 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000001782 263.0
HKD2_k127_6403899_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 7.963e-257 811.0
HKD2_k127_6403899_2 DNA recombination-mediator protein A K04096 - - 0.000003578 49.0
HKD2_k127_6421749_0 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008858 421.0
HKD2_k127_6421749_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 365.0
HKD2_k127_6421749_2 response regulator K02485 - - 0.000000000000000000000004975 106.0
HKD2_k127_6421749_3 COG1522 Transcriptional regulators - - - 0.000000005576 63.0
HKD2_k127_6427375_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 6.043e-294 920.0
HKD2_k127_6427375_1 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 366.0
HKD2_k127_6427375_2 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000008749 268.0
HKD2_k127_6427375_3 phosphoesterase RecJ domain protein K06881 GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000009465 265.0
HKD2_k127_6427375_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000000000000001099 153.0
HKD2_k127_6455154_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003868 577.0
HKD2_k127_6455154_1 anti-sigma regulatory factor K04757 - 2.7.11.1 0.0000000000000000000000000006919 118.0
HKD2_k127_6455174_0 Ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 448.0
HKD2_k127_6455174_1 Chromate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 435.0
HKD2_k127_6455174_10 ACT domain protein - - - 0.0002146 49.0
HKD2_k127_6455174_2 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007958 273.0
HKD2_k127_6455174_3 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000001425 232.0
HKD2_k127_6455174_4 Universal stress protein family K07090 - - 0.00000000000000000000000000000000000000000000000000000000000001138 226.0
HKD2_k127_6455174_5 Chromate resistance exported protein - - - 0.0000000000000000000000000000000000000000000000000000009854 204.0
HKD2_k127_6455174_6 Cyclophilin-like K09143 - - 0.000000000000000000000000000000000000000000000006489 174.0
HKD2_k127_6455174_7 PFAM Smr protein MutS2 - - - 0.000000000000000000000000000001886 123.0
HKD2_k127_6455174_8 pyrroloquinoline quinone binding - - - 0.000000000000000000000000005949 128.0
HKD2_k127_6455174_9 Transposase IS200 like K07491 - - 0.0000001234 56.0
HKD2_k127_648_0 LysM domain K08307,K12204,K16291 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003971 345.0
HKD2_k127_648_1 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000008871 237.0
HKD2_k127_648_2 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000001781 111.0
HKD2_k127_648_3 - - - - 0.0000000000000006805 82.0
HKD2_k127_6483841_0 Belongs to the peptidase M16 family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000001313 260.0
HKD2_k127_6483841_1 WHG domain - - - 0.00000000000000000000000000000000000000000000000000003834 194.0
HKD2_k127_6483841_2 Flavodoxin-like fold - - - 0.000000000000000000000000000000006046 139.0
HKD2_k127_6495460_0 ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 308.0
HKD2_k127_6495460_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002387 242.0
HKD2_k127_6495460_2 response regulator K02485 - - 0.0000000000000000000000000000000000000000000000000002142 188.0
HKD2_k127_6495460_3 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000001141 130.0
HKD2_k127_6495460_4 Phage integrase family - - - 0.00000000000000000000121 98.0
HKD2_k127_6495460_5 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0001929 48.0
HKD2_k127_6496940_0 flagellar basal-body rod protein FlgG K02392 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 332.0
HKD2_k127_6496940_1 PFAM Metal-dependent hydrolase HDOD - - - 0.00000000000000000000000000000000000000000000000000000000000000000001878 243.0
HKD2_k127_6496940_2 PFAM flagellar basal body rod protein K02392 - - 0.000000000000000000000000000000000000000002079 165.0
HKD2_k127_6496940_3 HDOD domain - - - 0.00000000000000000000000000272 120.0
HKD2_k127_6496940_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000001087 77.0
HKD2_k127_6496940_5 - - - - 0.0007338 47.0
HKD2_k127_6514267_0 transporter antisigma-factor antagonist STAS K03321 - - 1.439e-226 718.0
HKD2_k127_6514267_1 alcohol dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 484.0
HKD2_k127_6514267_2 SEC-C motif K09858 - - 0.0000000000000000000000000000000000000000000000000000000000000002054 224.0
HKD2_k127_6514267_3 Belongs to the SfsA family K06206 - - 0.000000000000000000000009254 103.0
HKD2_k127_6514267_4 Protein of unknown function (DUF1161) - - - 0.0000000000000000004713 88.0
HKD2_k127_6544062_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 8.724e-297 921.0
HKD2_k127_6544062_1 Domains GAF, HisKA, HATPase_c, GAF, HD-GYP-related - - - 4.192e-270 851.0
HKD2_k127_6544062_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 9.173e-198 636.0
HKD2_k127_6544062_3 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000008115 245.0
HKD2_k127_6544062_4 Methyl-accepting chemotaxis protein K03406 - - 0.0000000000000000000000000000000000000000000000000000000000005704 232.0
HKD2_k127_6544062_5 Polysaccharide export protein K01991,K20988 - - 0.00000000000000000000000000000000000000001734 167.0
HKD2_k127_6544062_6 Transcriptional regulator containing an HTH domain fused to a Zn-ribbon K07743 - - 0.000000000000000000000000000008365 121.0
HKD2_k127_6544062_7 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.000000000000000000001187 99.0
HKD2_k127_6544062_8 iron ion homeostasis - - - 0.00002085 55.0
HKD2_k127_6547598_0 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 529.0
HKD2_k127_6547598_2 RNA-binding - - - 0.0000000000000000000000005451 111.0
HKD2_k127_6547598_3 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000001037 70.0
HKD2_k127_6552864_0 Arsenite efflux pump ACR3 and related permeases K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000374 544.0
HKD2_k127_6552864_1 chelatase, subunit ChlI K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008594 347.0
HKD2_k127_6552864_10 Belongs to the peptidase S1C family K04771 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 0.000000000000000000002015 108.0
HKD2_k127_6552864_11 Glycosyl transferase family 41 - - - 0.00000000000001445 86.0
HKD2_k127_6552864_2 CO dehydrogenase acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 300.0
HKD2_k127_6552864_3 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000001015 213.0
HKD2_k127_6552864_4 DGC domain - - - 0.00000000000000000000000000000000000000000000000000005471 191.0
HKD2_k127_6552864_5 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 0.000000000000000000000000000000000000000000000000004281 193.0
HKD2_k127_6552864_6 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000008681 171.0
HKD2_k127_6552864_7 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000006741 168.0
HKD2_k127_6552864_8 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000000000000001372 139.0
HKD2_k127_6552864_9 4Fe-4S binding domain - - - 0.00000000000000000000000000000003502 127.0
HKD2_k127_6588361_0 binding domain protein K07138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 406.0
HKD2_k127_6588361_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K13924 - 2.1.1.80,3.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 310.0
HKD2_k127_6588361_2 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.000000000000000000000000000000000000000000000000003469 184.0
HKD2_k127_6588361_3 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000000005944 99.0
HKD2_k127_6594929_0 GTP-binding protein TypA K06207 - - 2.351e-267 834.0
HKD2_k127_6594929_1 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 492.0
HKD2_k127_6594929_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006574 447.0
HKD2_k127_6594929_3 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 411.0
HKD2_k127_6594929_4 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002082 282.0
HKD2_k127_6594929_5 - - - - 0.000000000000000000000000000000000003454 141.0
HKD2_k127_6594929_6 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.00000000000000006889 81.0
HKD2_k127_6594929_7 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000001485 52.0
HKD2_k127_6615022_0 Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00124,K00335,K00355,K18331 - 1.12.1.3,1.6.5.2,1.6.5.3 8.536e-273 852.0
HKD2_k127_6615022_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 557.0
HKD2_k127_6615022_10 PHP-associated K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000000000002195 209.0
HKD2_k127_6615022_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000008438 198.0
HKD2_k127_6615022_12 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K18330 - 1.12.1.3 0.000000000000000000000000000000000000000000000001046 184.0
HKD2_k127_6615022_13 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000003056 178.0
HKD2_k127_6615022_14 Ferredoxin K17992 - 1.12.1.3 0.000000000000000000000000000000000000000001107 160.0
HKD2_k127_6615022_15 Domain in cystathionine beta-synthase and other proteins. K06041 - 5.3.1.13 0.00000000000000000000000000000000000000006054 155.0
HKD2_k127_6615022_16 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000000000001212 147.0
HKD2_k127_6615022_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000000000003887 145.0
HKD2_k127_6615022_18 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000003799 133.0
HKD2_k127_6615022_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000000002465 126.0
HKD2_k127_6615022_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 552.0
HKD2_k127_6615022_20 DRTGG domain - - - 0.0000000000000000000000000000004865 125.0
HKD2_k127_6615022_21 DRTGG domain - - - 0.00000000000000000000000000001433 121.0
HKD2_k127_6615022_22 Sigma-54 dependent response regulator K07714 - - 0.00000000000000000000000000004807 120.0
HKD2_k127_6615022_23 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000003777 75.0
HKD2_k127_6615022_24 Transcriptional regulator, Crp Fnr family K10914 - - 0.00000000000003637 79.0
HKD2_k127_6615022_25 Signal transducing histidine kinase, homodimeric domain K03407 - 2.7.13.3 0.000000000111 74.0
HKD2_k127_6615022_26 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L K00341 - 1.6.5.3 0.0000000001154 64.0
HKD2_k127_6615022_3 response regulator K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 484.0
HKD2_k127_6615022_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 444.0
HKD2_k127_6615022_5 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 388.0
HKD2_k127_6615022_6 Histidine kinase K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009974 344.0
HKD2_k127_6615022_7 (Rhomboid) family - - - 0.000000000000000000000000000000000000000000000000000000000000005583 223.0
HKD2_k127_6615022_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000004113 214.0
HKD2_k127_6615022_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000001163 217.0
HKD2_k127_6627185_0 Belongs to the GPI family K01810 - 5.3.1.9 1.076e-267 834.0
HKD2_k127_6627185_1 cell redox homeostasis - - - 5.234e-220 691.0
HKD2_k127_6627185_2 Sensory domain found in PocR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 482.0
HKD2_k127_6627185_3 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008391 360.0
HKD2_k127_6627185_4 histidine kinase, HAMP K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000004036 269.0
HKD2_k127_6627185_5 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.00000000000000000000000000000000005057 136.0
HKD2_k127_6643804_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 1.842e-263 824.0
HKD2_k127_6643804_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 8.91e-212 664.0
HKD2_k127_6643804_2 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003096 437.0
HKD2_k127_6643804_3 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000001959 234.0
HKD2_k127_6643804_4 PFAM Amino acid-binding ACT - - - 0.00000000000000000000000000000000000000000000000000000000001991 208.0
HKD2_k127_6672864_0 DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity K03581 - 3.1.11.5 1.275e-318 990.0
HKD2_k127_6672864_1 Tfp pilus assembly protein tip-associated adhesin K02674 - - 4.824e-271 889.0
HKD2_k127_6672864_2 Response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 461.0
HKD2_k127_6672864_3 Uncharacterised nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005599 348.0
HKD2_k127_6672864_4 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000004236 156.0
HKD2_k127_6672864_5 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000267 126.0
HKD2_k127_6672864_6 acetolactate decarboxylase activity K01575 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0047605 4.1.1.5 0.0000000000000000000003275 105.0
HKD2_k127_6672864_7 Prokaryotic N-terminal methylation motif - - - 0.000002368 58.0
HKD2_k127_6672864_8 2-epimerase K16213 - 5.1.3.11 0.000051 49.0
HKD2_k127_6682070_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 433.0
HKD2_k127_6688700_0 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001932 284.0
HKD2_k127_6688700_1 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002764 280.0
HKD2_k127_6688700_2 oligosaccharyl transferase activity - - - 0.000000000000000000000000002765 130.0
HKD2_k127_6688700_3 PFAM Tetratricopeptide repeat - - - 0.0000881 56.0
HKD2_k127_6693318_0 PFAM flavin reductase domain protein, FMN-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004431 276.0
HKD2_k127_6693318_1 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000005773 181.0
HKD2_k127_6693318_2 regulation of translation K03530 - - 0.0000000000000000000000000000000001276 134.0
HKD2_k127_6693318_3 Nitroreductase family - - - 0.0000000000000000000000000000000009026 137.0
HKD2_k127_6693318_4 - - - - 0.00000000000000000000000000003697 120.0
HKD2_k127_6694562_0 Nitrite and sulphite reductase 4Fe-4S K11180 - 1.8.99.5 3.225e-209 656.0
HKD2_k127_6694562_1 Nitrite and sulphite reductase 4Fe-4S K11181 - 1.8.99.5 3.542e-200 628.0
HKD2_k127_6694562_2 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002141 580.0
HKD2_k127_6694562_3 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 507.0
HKD2_k127_6694562_4 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007364 502.0
HKD2_k127_6694562_5 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003345 481.0
HKD2_k127_6694562_6 lyase activity - - - 0.0000000000000000000000000000109 123.0
HKD2_k127_6694562_8 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0009153 44.0
HKD2_k127_6714324_0 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 6.012e-258 816.0
HKD2_k127_6714324_1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01840,K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 531.0
HKD2_k127_6714324_10 deoxyribonuclease V activity K05982 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0043737,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.7 0.0000000000000000000000000000000000000000000000000000000000004028 221.0
HKD2_k127_6714324_11 Protein of unknown function (DUF3108) - - - 0.0000000000000000000000000000000000000000000000000000000003832 212.0
HKD2_k127_6714324_12 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000002206 164.0
HKD2_k127_6714324_13 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000006802 151.0
HKD2_k127_6714324_14 Transcriptional regulator, MerR family - - - 0.000000000000000000000000000000001268 134.0
HKD2_k127_6714324_15 O-Antigen ligase K02847 - - 0.00000000000000009079 93.0
HKD2_k127_6714324_16 Part of a membrane complex involved in electron transport K03612 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0002532 48.0
HKD2_k127_6714324_2 Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily K03615 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 495.0
HKD2_k127_6714324_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003524 424.0
HKD2_k127_6714324_4 Phosphomethylpyrimidine kinase K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008709 368.0
HKD2_k127_6714324_5 Part of a membrane complex involved in electron transport K03614 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 361.0
HKD2_k127_6714324_6 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 307.0
HKD2_k127_6714324_7 Thiamine biosynthesis protein (ThiI) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 304.0
HKD2_k127_6714324_8 transferase activity, transferring glycosyl groups K13500 - 2.4.1.175,2.4.1.226 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008594 289.0
HKD2_k127_6714324_9 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004207 285.0
HKD2_k127_6715459_0 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008989 309.0
HKD2_k127_6715459_1 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009542 307.0
HKD2_k127_6715459_2 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 303.0
HKD2_k127_6715459_3 transcriptional regulator - GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000001249 249.0
HKD2_k127_6723672_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.467e-229 728.0
HKD2_k127_6723672_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 1.963e-221 702.0
HKD2_k127_6723672_2 PFAM Aminotransferase class I and II K10206,K14261 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 598.0
HKD2_k127_6723672_3 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 513.0
HKD2_k127_6723672_4 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 444.0
HKD2_k127_6723672_5 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 383.0
HKD2_k127_6723672_6 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 332.0
HKD2_k127_6723672_7 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002995 243.0
HKD2_k127_6723672_8 SMART Cold shock protein K03704 - - 0.00000000000000000000000004793 108.0
HKD2_k127_6723672_9 PFAM import inner membrane translocase, subunit Tim44 - - - 0.000000000000000001722 90.0
HKD2_k127_6727200_0 Ftsk_gamma K03466 - - 2.133e-214 686.0
HKD2_k127_6727200_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001572 268.0
HKD2_k127_6727200_2 DoxX K15977 - - 0.00000000000000000000000000000000000000000000008899 171.0
HKD2_k127_6760875_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789,K18138 - - 6.977e-283 881.0
HKD2_k127_6760875_1 HlyD membrane-fusion protein of T1SS K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001617 381.0
HKD2_k127_6760875_2 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007797 281.0
HKD2_k127_6824626_0 AAA domain, putative AbiEii toxin, Type IV TA system K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001785 266.0
HKD2_k127_6824626_1 Cobalt transport protein K02008 - - 0.000000000000000000000000000000000003738 148.0
HKD2_k127_6857273_0 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006228 471.0
HKD2_k127_6857273_1 Phage integrase, N-terminal SAM-like domain K03733 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006859 343.0
HKD2_k127_6857273_2 HDOD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005627 312.0
HKD2_k127_6857273_3 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002886 267.0
HKD2_k127_6857273_4 Diguanylate cyclase, GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000005023 244.0
HKD2_k127_6857273_5 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.0000000007581 60.0
HKD2_k127_6857273_6 PFAM Metal-dependent phosphohydrolase, HD - - - 0.00000004734 59.0
HKD2_k127_6927079_0 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 569.0
HKD2_k127_6927079_1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000217 537.0
HKD2_k127_6927079_3 metal-dependent phosphohydrolase HD region - - - 0.00000000001001 66.0
HKD2_k127_6927079_4 protein conserved in bacteria K09796 - - 0.0000000009617 66.0
HKD2_k127_6958380_0 Transport of potassium into the cell K03549 - - 8.381e-253 794.0
HKD2_k127_6958380_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 1.475e-231 735.0
HKD2_k127_6958380_2 O-Antigen ligase - - - 0.00000000000000000000000000000000000000000004274 177.0
HKD2_k127_6982666_0 Pyridoxal-phosphate dependent enzyme K06001 - 4.2.1.20 7.728e-222 698.0
HKD2_k127_6982666_1 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 516.0
HKD2_k127_6982666_10 ABC transporter K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000315 227.0
HKD2_k127_6982666_11 lactate metabolic process K11473,K18928 - - 0.00000000000000000000000000000000000000000000000000000000000001214 229.0
HKD2_k127_6982666_12 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000002131 217.0
HKD2_k127_6982666_13 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.000000000000000000000000000000000000000000000000000000001471 208.0
HKD2_k127_6982666_14 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000528 200.0
HKD2_k127_6982666_15 Belongs to the ABC-4 integral membrane protein family. FtsX subfamily K09811 - - 0.000000000000000000000000000000000000000005385 166.0
HKD2_k127_6982666_16 peroxiredoxin activity - - - 0.0000000000000000000000000000009831 127.0
HKD2_k127_6982666_18 - - - - 0.00000000000000000000183 99.0
HKD2_k127_6982666_19 Regulatory protein, FmdB family - - - 0.000000000000000000006408 94.0
HKD2_k127_6982666_2 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001425 454.0
HKD2_k127_6982666_3 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009168 421.0
HKD2_k127_6982666_4 Dehydrogenase E1 component K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 413.0
HKD2_k127_6982666_5 Lysin motif K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002305 394.0
HKD2_k127_6982666_6 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 310.0
HKD2_k127_6982666_7 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000006039 243.0
HKD2_k127_6982666_8 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000006817 240.0
HKD2_k127_6982666_9 Peptidase family M23 K21471 - - 0.0000000000000000000000000000000000000000000000000000000000000000004641 243.0
HKD2_k127_6999402_0 ATP synthase alpha/beta family, beta-barrel domain K02412 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 512.0
HKD2_k127_6999402_1 phosphorelay signal transduction system K07713,K07714,K10943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 454.0
HKD2_k127_6999402_2 The M ring may be actively involved in energy transduction K02409 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 416.0
HKD2_k127_6999402_3 FliG middle domain K02410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 304.0
HKD2_k127_6999402_4 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000005 207.0
HKD2_k127_6999402_5 Belongs to the flagella basal body rod proteins family K02388 - - 0.0000000000000000000000000000000000001392 147.0
HKD2_k127_6999402_6 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.000000000000001506 81.0
HKD2_k127_6999402_7 Flagellar hook-basal body complex protein FliE K02408 - - 0.00000000000009435 75.0
HKD2_k127_6999402_8 Flagellar assembly protein FliH K02411 - - 0.000000000004162 75.0
HKD2_k127_6999402_9 PFAM MgtE intracellular - - - 0.00003488 53.0
HKD2_k127_7114020_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1450.0
HKD2_k127_7114020_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003746 383.0
HKD2_k127_7114020_2 YtkA-like - - - 0.0000000000000000000000000006295 117.0
HKD2_k127_7114020_3 Protein of unknown function (DUF2892) - - - 0.0000000000000000000355 91.0
HKD2_k127_7114020_4 Protein of unknown function with PCYCGC motif - - - 0.00000004278 58.0
HKD2_k127_7237057_0 PFAM Aldehyde ferredoxin oxidoreductase K03738 - 1.2.7.5 2.194e-271 845.0
HKD2_k127_7237057_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 2.454e-209 657.0
HKD2_k127_7237057_2 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 9.531e-200 627.0
HKD2_k127_7237057_3 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 - 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 367.0
HKD2_k127_7237057_4 PFAM 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007825 253.0
HKD2_k127_7237057_5 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins K09181,K15520 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 2.3.1.189 0.000000000000000000000000000000000000000000000000000006313 195.0
HKD2_k127_7237057_6 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000002326 51.0
HKD2_k127_7249380_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 534.0
HKD2_k127_7249380_1 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 310.0
HKD2_k127_7249380_2 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000002735 203.0
HKD2_k127_7249380_3 Tetratricopeptide repeats - - - 0.0000000000000000000000000000000000000000000000000000003091 219.0
HKD2_k127_7249380_5 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000006874 63.0
HKD2_k127_7264428_0 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000000000000000000000000000000000000000000000008392 231.0
HKD2_k127_7264428_1 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.000000000000000000000000000000000000000002512 164.0
HKD2_k127_7264428_2 PFAM Flagellar hook-length control K02414 - - 0.00000003475 66.0
HKD2_k127_7264428_3 C-terminal, D2-small domain, of ClpB protein K03667 - - 0.00003657 46.0
HKD2_k127_7448708_0 calcium, potassium:sodium antiporter activity K07301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007163 352.0
HKD2_k127_7448708_1 response regulator, receiver K03413 - - 0.000000000000000000000000001112 116.0
HKD2_k127_7448708_2 - - - - 0.000000000000000444 82.0
HKD2_k127_7448708_3 Belongs to the universal stress protein A family - - - 0.000000000004323 74.0
HKD2_k127_7477158_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 7.131e-229 743.0
HKD2_k127_7477158_1 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 426.0
HKD2_k127_7477158_2 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 383.0
HKD2_k127_7477158_3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000008085 262.0
HKD2_k127_7477158_4 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000004422 226.0
HKD2_k127_7477158_5 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.000000000000000000000000000000000000000000000000000000001061 204.0
HKD2_k127_7477158_7 Belongs to the Nudix hydrolase family - - - 0.000000000000000000000000000000002014 134.0
HKD2_k127_7608636_0 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006231 605.0
HKD2_k127_7608636_1 Bacterial regulatory protein, Fis family K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 551.0
HKD2_k127_7608636_2 GHKL domain K13598 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 538.0
HKD2_k127_7608636_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007451 459.0
HKD2_k127_7608636_5 NADH-quinone oxidoreductase K00341,K05568,K12139 - 1.6.5.3 0.0000000000000000000000000000004847 125.0
HKD2_k127_7618196_0 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000005562 257.0
HKD2_k127_7618196_1 Protein of unknown function (DUF815) K06923 - - 0.000000000000000000000000000000000000000000000000000000002291 209.0
HKD2_k127_7618196_2 PFAM response regulator receiver K07657,K07658 - - 0.000000000000000000000000002058 115.0
HKD2_k127_7618196_4 Cellulose synthase operon protein C C-terminus (BCSC_C) K20543 - - 0.00009084 55.0
HKD2_k127_770914_0 Heat shock 70 kDa protein K04043 - - 0.0 1017.0
HKD2_k127_770914_1 negative regulation of protein lipidation K19294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 585.0
HKD2_k127_770914_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 432.0
HKD2_k127_770914_3 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 336.0
HKD2_k127_770914_4 SGNH hydrolase-like domain, acetyltransferase AlgX K19295 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007341 273.0
HKD2_k127_770914_5 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000005219 178.0
HKD2_k127_770914_6 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000000004218 167.0
HKD2_k127_770914_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000008695 107.0
HKD2_k127_7720106_0 Surface antigen K07277 - - 4.115e-228 726.0
HKD2_k127_7720106_1 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000004865 228.0
HKD2_k127_7748190_0 membrane transporter protein K07090 - - 4.954e-207 650.0
HKD2_k127_7748190_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000002138 241.0
HKD2_k127_7748190_2 helix_turn_helix gluconate operon transcriptional repressor K03710 - - 0.00000000000000000000000000000000004456 143.0
HKD2_k127_7767456_0 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000969 312.0
HKD2_k127_7767456_1 MgtE intracellular - - - 0.000000000000000000000000000000000000000000103 166.0
HKD2_k127_7767456_2 lipolytic protein G-D-S-L family - - - 0.00000000000000000000000000000000000000001218 159.0
HKD2_k127_7767456_3 Nitroreductase family - - - 0.0000000000000001064 80.0
HKD2_k127_7778388_0 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 548.0
HKD2_k127_7778388_1 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K13819 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 357.0
HKD2_k127_7778388_2 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 347.0
HKD2_k127_7818173_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002022 460.0
HKD2_k127_7818173_1 COGs COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000086 209.0
HKD2_k127_7818173_2 four-way junction helicase activity K03550 GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 0.00000000000000000000000000000000000000002225 158.0
HKD2_k127_7818173_3 Methyltransferase domain - - - 0.000000000000000000000000000007062 126.0
HKD2_k127_7841929_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1191.0
HKD2_k127_7841929_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821,K09251 - 2.6.1.11,2.6.1.17,2.6.1.82 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 425.0
HKD2_k127_7841929_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002706 274.0
HKD2_k127_7841929_3 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000000000000000000000000001929 146.0
HKD2_k127_7841929_4 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000007171 129.0
HKD2_k127_7841929_5 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.000000000000000796 81.0
HKD2_k127_7872184_0 Sigma-54 interaction domain - - - 2.757e-231 729.0
HKD2_k127_7872184_1 Molybdopterin oxidoreductase Fe4S4 domain K00123,K22341 - 1.17.1.11,1.17.1.9 1.302e-198 632.0
HKD2_k127_7872184_10 Domain of unknown function (DUF296) - - - 0.000000000000000000000000000000000000000000000000000000005626 202.0
HKD2_k127_7872184_11 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000000000000000000000000000000000000000007164 196.0
HKD2_k127_7872184_12 Type II secretion system (T2SS), protein K K02460 - - 0.0000000000000000000000000000000000000000000000000004224 197.0
HKD2_k127_7872184_13 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000002065 181.0
HKD2_k127_7872184_14 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.000000000000000000000000000000000000000000001704 188.0
HKD2_k127_7872184_15 PhoQ Sensor - - - 0.000000000000000000000000000000000000000007057 177.0
HKD2_k127_7872184_16 - - - - 0.00000000000000000000006874 112.0
HKD2_k127_7872184_17 fimbrial assembly K02461 - - 0.0000000000002316 83.0
HKD2_k127_7872184_18 pilus assembly protein PilW K02459,K02672 - - 0.000000009624 66.0
HKD2_k127_7872184_19 Type II secretion system (T2SS), protein M subtype b - - - 0.00000122 57.0
HKD2_k127_7872184_2 type II secretion system protein E K02454 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005519 567.0
HKD2_k127_7872184_20 - - - - 0.000001243 56.0
HKD2_k127_7872184_21 type IV pilus modification protein PilV K02458 - - 0.000005631 55.0
HKD2_k127_7872184_22 General secretion pathway protein K02457 - - 0.00009659 51.0
HKD2_k127_7872184_3 molybdopterin oxidoreductase Fe4S4 region K05299 - 1.17.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005533 488.0
HKD2_k127_7872184_4 pseudouridine synthase activity K06176 - 5.4.99.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000926 425.0
HKD2_k127_7872184_5 Type II secretion system (T2SS), protein F K02455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 370.0
HKD2_k127_7872184_6 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002652 332.0
HKD2_k127_7872184_7 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008222 348.0
HKD2_k127_7872184_8 Bacterial type II and III secretion system protein K02453,K03219 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000171 292.0
HKD2_k127_7872184_9 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000005259 237.0
HKD2_k127_7929402_0 COG0463 Glycosyltransferases involved in cell wall biogenesis K13693 - 2.4.1.266 8.111e-202 635.0
HKD2_k127_7929402_1 glycosyl transferase family 2 K21349 - 2.4.1.268 6.311e-195 615.0
HKD2_k127_7929402_2 MOFRL family K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 447.0
HKD2_k127_7929402_3 haloacid dehalogenase-like hydrolase K07026 - 3.1.3.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009941 315.0
HKD2_k127_7929402_4 transmembrane transport - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003862 250.0
HKD2_k127_7929402_5 ATP synthase subunit D K02120 - - 0.000000000000000000000000000000000000000000000000000006061 194.0
HKD2_k127_7929402_6 Domain of Unknown Function (DUF1259) - - - 0.0000000000000000000000000000001634 127.0
HKD2_k127_7929402_7 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000005331 104.0
HKD2_k127_7929402_8 Universal stress protein family K07090 - - 0.000000000661 61.0
HKD2_k127_7976969_0 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 415.0
HKD2_k127_7976969_1 Nitrous oxide-stimulated promoter - - - 0.0000000000000000000000000000000000000001254 153.0
HKD2_k127_7976969_2 Domain of unknown function (DUF4416) - - - 0.000000000000000000002673 94.0
HKD2_k127_7983210_0 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 355.0
HKD2_k127_7983210_1 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 346.0
HKD2_k127_7983210_2 cytochrome C - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006672 276.0
HKD2_k127_7983210_3 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003345 272.0
HKD2_k127_7983210_4 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000001375 241.0
HKD2_k127_7983210_5 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.0000000000000000000000000000000000000000000000000000000000000000871 226.0
HKD2_k127_7983210_6 MotA/TolQ/ExbB proton channel family K03562 - - 0.000000000000000000000000000000000000000000000000000000000002361 216.0
HKD2_k127_7983210_7 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000000000000000000005279 153.0
HKD2_k127_7983210_8 Biopolymer transport protein ExbD/TolR K03560 - - 0.000000000000000000000000000000000003421 146.0
HKD2_k127_8001366_0 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 1.644e-262 821.0
HKD2_k127_8001366_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 528.0
HKD2_k127_8001366_2 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 385.0
HKD2_k127_8001366_3 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000001426 189.0
HKD2_k127_8001366_4 PFAM Glucosamine-6-phosphate isomerases 6-phosphogluconolactonase K01057 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 0.000000000000000000000000000000000000000000000004776 181.0
HKD2_k127_8001366_5 Universal stress protein - - - 0.000000144 57.0
HKD2_k127_8032256_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 4.176e-213 672.0
HKD2_k127_8032256_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123,K05299,K22341 - 1.17.1.10,1.17.1.11,1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004955 553.0
HKD2_k127_8032256_2 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009449 516.0
HKD2_k127_8032256_3 Thioredoxin-like [2Fe-2S] ferredoxin K00334 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050136,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000000000002717 131.0
HKD2_k127_8083558_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.099e-230 730.0
HKD2_k127_8083558_1 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 312.0
HKD2_k127_8083558_2 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 286.0
HKD2_k127_8083558_3 - - - - 0.00000000000000000000001508 109.0
HKD2_k127_8083558_4 diaminopimelate decarboxylase activity K01581 - 4.1.1.17 0.0000000000000000000001496 98.0
HKD2_k127_8083558_5 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000001651 96.0
HKD2_k127_8084410_0 Methyl-viologen-reducing hydrogenase, delta subunit K03388,K16885,K16886 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1044.0
HKD2_k127_8084410_1 nitrate reductase activity K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005365 431.0
HKD2_k127_8084410_2 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.000000000000000000001383 95.0
HKD2_k127_8084410_3 FAD dependent oxidoreductase K16885 - - 0.0000000000000000004943 88.0
HKD2_k127_8193734_0 PFAM tRNA synthetases class II (D, K and N) K01893 - 6.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 595.0
HKD2_k127_8193734_1 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008278 565.0
HKD2_k127_8193734_2 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 351.0
HKD2_k127_8193734_3 Ndr family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008457 254.0
HKD2_k127_8193734_4 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005268 251.0
HKD2_k127_8193734_5 O-methyltransferase K00588 - 2.1.1.104 0.00000000000000000000000000000000000000000000000000000004103 207.0
HKD2_k127_8193734_6 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000001678 200.0
HKD2_k127_8193734_8 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000001959 78.0
HKD2_k127_8193734_9 Cytochrome C oxidase, cbb3-type, subunit III K02305 - - 0.00003188 47.0
HKD2_k127_8196715_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 5.088e-204 644.0
HKD2_k127_8196715_1 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007436 425.0
HKD2_k127_8196715_2 LysM domain - - - 0.0000000000000000000000000000000001519 145.0
HKD2_k127_8199009_0 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 332.0
HKD2_k127_8199009_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007342 281.0
HKD2_k127_8199009_10 Belongs to the universal ribosomal protein uL29 family K02904 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000006988 75.0
HKD2_k127_8199009_11 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000001221 67.0
HKD2_k127_8199009_2 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000007489 232.0
HKD2_k127_8199009_3 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000002194 201.0
HKD2_k127_8199009_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000133 169.0
HKD2_k127_8199009_5 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.00000000000000000000000000000000000000006413 154.0
HKD2_k127_8199009_6 Ribosomal protein L22p/L17e K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000001864 127.0
HKD2_k127_8199009_7 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000000003352 106.0
HKD2_k127_8199009_8 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000008939 105.0
HKD2_k127_8199009_9 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000001443 96.0
HKD2_k127_8213355_0 PFAM AMP-dependent synthetase and ligase K01908 - 6.2.1.17 0.0 1080.0
HKD2_k127_8213355_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004817 321.0
HKD2_k127_8213355_2 Di-haem cytochrome c peroxidase - - - 0.00000000004526 63.0
HKD2_k127_8229162_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 308.0
HKD2_k127_8229162_1 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000000000001759 212.0
HKD2_k127_8229162_2 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000004106 161.0
HKD2_k127_8229162_3 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000001729 150.0
HKD2_k127_8229162_4 PFAM nitrogen-fixing NifU domain protein - - - 0.000000000000000000000002494 103.0
HKD2_k127_8229162_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000003698 73.0
HKD2_k127_829235_0 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00335 - 1.6.5.3 1.788e-248 779.0
HKD2_k127_829235_1 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009757 313.0
HKD2_k127_829235_10 PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00124,K00335 - 1.6.5.3 0.00000000000000000000000001614 114.0
HKD2_k127_829235_11 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000008595 85.0
HKD2_k127_829235_2 LysM domain K01449,K19223 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000001837 245.0
HKD2_k127_829235_3 Aminoacyl-tRNA editing domain K03976 - - 0.00000000000000000000000000000000000000000000000000000000000001864 218.0
HKD2_k127_829235_4 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000001446 198.0
HKD2_k127_829235_5 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000000000000000001037 185.0
HKD2_k127_829235_6 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000003439 173.0
HKD2_k127_829235_7 PFAM Respiratory-chain NADH dehydrogenase 24 Kd subunit K00334,K18330 - 1.12.1.3,1.6.5.3 0.0000000000000000000000000000000000000000007455 162.0
HKD2_k127_829235_8 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 0.000000000000000000000000000000000000000001158 160.0
HKD2_k127_829235_9 VanZ like family - - - 0.0000000000000000000000000000000000009176 147.0
HKD2_k127_8325080_0 Galactose-1-phosphate uridyl transferase, C-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 331.0
HKD2_k127_8325080_1 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000003489 223.0
HKD2_k127_8325080_2 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000000000001733 181.0
HKD2_k127_8325080_3 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 0.000000000000000000005086 93.0
HKD2_k127_8325080_4 Universal stress protein K06149 - - 0.00000000001104 68.0
HKD2_k127_8352200_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006571 567.0
HKD2_k127_8352200_1 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 536.0
HKD2_k127_8352200_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 443.0
HKD2_k127_8352200_3 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 388.0
HKD2_k127_8352200_4 Evidence 2b Function of strongly homologous gene K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 303.0
HKD2_k127_8352200_5 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004889 306.0
HKD2_k127_8352200_6 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 297.0
HKD2_k127_8352200_7 transcriptional regulator - GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001915 260.0
HKD2_k127_8352200_8 Vitamin K epoxide reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001101 257.0
HKD2_k127_835755_0 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006838 509.0
HKD2_k127_8386121_0 DNA-directed DNA polymerase activity K02340 - 2.7.7.7 0.0000000000000000000000000001844 126.0
HKD2_k127_8386121_1 cheY-homologous receiver domain K03413 - - 0.0000000000000000000000005302 106.0
HKD2_k127_8386121_2 Binds directly to 16S ribosomal RNA K02968 - - 0.000000003029 62.0
HKD2_k127_8472884_0 PFAM SPFH domain Band 7 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 406.0
HKD2_k127_8472884_1 Psort location Cytoplasmic, score - - - 0.00000000001702 77.0
HKD2_k127_8472884_2 Nicotinic acid phosphoribosyltransferase K00763 - 6.3.4.21 0.00000000003453 64.0
HKD2_k127_8482043_0 membrane - - - 3.159e-267 835.0
HKD2_k127_8482043_1 Sugar (and other) transporter K03446 - - 1.08e-242 758.0
HKD2_k127_8482043_10 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000008877 221.0
HKD2_k127_8482043_11 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000006598 173.0
HKD2_k127_8482043_12 MarC family integral membrane protein - - - 0.0000000000000000000000000000000000000000005835 164.0
HKD2_k127_8482043_13 retrograde transport, endosome to Golgi K07095 - - 0.000000000000000000000000000000000000000001318 161.0
HKD2_k127_8482043_14 PFAM OmpA family K02557 - - 0.00000000000000000000000000000000005463 143.0
HKD2_k127_8482043_15 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000006495 143.0
HKD2_k127_8482043_16 Sulphur transport K07112 - - 0.0000000000000000000000000000001827 139.0
HKD2_k127_8482043_17 PFAM MotA TolQ ExbB proton channel K02556 - - 0.0000000000000000000000000000005082 133.0
HKD2_k127_8482043_18 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000000000000000001135 122.0
HKD2_k127_8482043_19 Universal stress protein family - - - 0.00000000000000000000000000003375 123.0
HKD2_k127_8482043_2 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005777 470.0
HKD2_k127_8482043_20 Peptidase family M54 K06974 - - 0.00000000000000000000000000004141 123.0
HKD2_k127_8482043_21 - - - - 0.0000000000000002313 85.0
HKD2_k127_8482043_23 Belongs to the sulfur carrier protein TusA family - - - 0.000000001066 67.0
HKD2_k127_8482043_24 Na( ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.000000002365 59.0
HKD2_k127_8482043_25 - - - - 0.000003978 51.0
HKD2_k127_8482043_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K01665,K03342,K13950 - 2.6.1.85,4.1.3.27,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 436.0
HKD2_k127_8482043_4 dUTP biosynthetic process K01494 GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 313.0
HKD2_k127_8482043_5 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 297.0
HKD2_k127_8482043_6 cyclic diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004646 251.0
HKD2_k127_8482043_7 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000605 261.0
HKD2_k127_8482043_8 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000004734 234.0
HKD2_k127_8482043_9 lyase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000003114 249.0
HKD2_k127_84832_0 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 385.0
HKD2_k127_84832_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 340.0
HKD2_k127_84832_10 Anti-sigma-28 factor, FlgM K02398 - - 0.0002229 48.0
HKD2_k127_84832_2 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002486 277.0
HKD2_k127_84832_3 Flagellar basal body rod FlgEFG protein C-terminal K02396 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004554 287.0
HKD2_k127_84832_4 PFAM inositol monophosphatase K01082 - 3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000001279 265.0
HKD2_k127_84832_5 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.00000000000000000000000000000000000000000000000000000000002605 213.0
HKD2_k127_84832_6 Peptidase family M23 - - - 0.000000000000000000000000000000000000000007313 164.0
HKD2_k127_84832_7 Belongs to the bacterial flagellin family K02397 - - 0.00000000000000000002887 103.0
HKD2_k127_84832_8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding K03563 - - 0.00000000000003768 75.0
HKD2_k127_84832_9 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.00000000003 73.0
HKD2_k127_8544691_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.479e-228 718.0
HKD2_k127_8544691_1 ACT domain K00928 - 2.7.2.4 2.019e-202 636.0
HKD2_k127_8544691_10 iron ion homeostasis - - - 0.0001549 52.0
HKD2_k127_8544691_2 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 602.0
HKD2_k127_8544691_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 550.0
HKD2_k127_8544691_4 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 550.0
HKD2_k127_8544691_5 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 334.0
HKD2_k127_8544691_6 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000006351 205.0
HKD2_k127_8544691_7 Polysaccharide export protein K01991 - - 0.00000000000000000000000000000000000000000000000000027 198.0
HKD2_k127_8544691_8 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000002811 196.0
HKD2_k127_8544691_9 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000189 57.0
HKD2_k127_8554011_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 3.153e-271 857.0
HKD2_k127_8554011_1 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 2.732e-249 776.0
HKD2_k127_8554011_10 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000006009 233.0
HKD2_k127_8554011_11 Biogenesis protein K09792 - - 0.00000000000000000000000000000000000000000000000000000000001518 215.0
HKD2_k127_8554011_12 Thioesterase superfamily K19222 - 3.1.2.28 0.000000000000000000000000000000000000000000000000003062 185.0
HKD2_k127_8554011_13 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000001143 144.0
HKD2_k127_8554011_14 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000000000000000001143 120.0
HKD2_k127_8554011_15 FixH - - - 0.0000000000000000000001491 103.0
HKD2_k127_8554011_16 Cytochrome C oxidase, cbb3-type, subunit III K00406 - - 0.0000000000000001692 85.0
HKD2_k127_8554011_17 N-terminal domain of cytochrome oxidase-cbb3, FixP - - - 0.00000000000001774 74.0
HKD2_k127_8554011_19 TIGRFAM cytochrome oxidase maturation protein, cbb3-type - - - 0.0000000000000474 75.0
HKD2_k127_8554011_2 PFAM ABC transporter related K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 508.0
HKD2_k127_8554011_20 - - - - 0.000000002194 59.0
HKD2_k127_8554011_21 FixH - - - 0.00001081 55.0
HKD2_k127_8554011_23 Cbb3-type cytochrome oxidase component FixQ - - - 0.0006648 44.0
HKD2_k127_8554011_3 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 462.0
HKD2_k127_8554011_4 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 455.0
HKD2_k127_8554011_5 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 378.0
HKD2_k127_8554011_6 PFAM cytochrome C oxidase mono-heme subunit FixO K00405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000434 338.0
HKD2_k127_8554011_7 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007566 332.0
HKD2_k127_8554011_8 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002489 285.0
HKD2_k127_8554011_9 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000001926 273.0
HKD2_k127_8560788_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 9.04e-243 758.0
HKD2_k127_8560788_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000002488 220.0
HKD2_k127_8560788_2 ATP synthesis coupled proton transport K02109,K18682 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000003212 171.0
HKD2_k127_8560788_3 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.000000000000000000000000000000000000001428 155.0
HKD2_k127_858894_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 383.0
HKD2_k127_858894_1 PFAM Phosphomethylpyrimidine kinase type-1 K00868,K00941,K14153 - 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000003237 228.0
HKD2_k127_858894_2 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000004782 63.0
HKD2_k127_8702886_0 PFAM GGDEF domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007584 377.0
HKD2_k127_8702886_1 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000000000000002824 254.0
HKD2_k127_8702886_2 peptidyl-prolyl cis-trans isomerase - - - 0.000000000000000000000000000000000000000001567 160.0
HKD2_k127_8702886_3 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000002139 134.0
HKD2_k127_8702886_4 - - - - 0.0000008391 57.0
HKD2_k127_8730494_0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002885 432.0
HKD2_k127_8730494_1 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 430.0
HKD2_k127_8730494_2 Seven times multi-haem cytochrome CxxCH - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000347 369.0
HKD2_k127_8730494_3 L,D-transpeptidase catalytic domain K21470 - - 0.0000000000000000000000000000002885 135.0
HKD2_k127_8730494_4 Protein of unknown function, DUF488 - - - 0.00000000000000003944 81.0
HKD2_k127_8730494_5 Cytochrome c - - - 0.00000000000002871 76.0
HKD2_k127_8730494_6 WD40-like Beta Propeller K03641 - - 0.000001434 60.0
HKD2_k127_885201_0 Secretin and TonB N terminus short domain K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004389 390.0
HKD2_k127_885201_1 Type IV pilus assembly protein PilM; K02662 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006182 354.0
HKD2_k127_885201_2 PFAM Pilus assembly protein PilO K02664 - - 0.00000000000001942 81.0
HKD2_k127_885201_3 Fimbrial assembly protein (PilN) K02663 - - 0.00000000000004961 79.0
HKD2_k127_885201_4 Pilus assembly protein, PilP K02665 - - 0.0000000000806 70.0
HKD2_k127_885201_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K13735 GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009279,GO:0009405,GO:0009987,GO:0016020,GO:0019867,GO:0022610,GO:0030260,GO:0030312,GO:0030313,GO:0031589,GO:0031975,GO:0042710,GO:0043708,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944,GO:0090605 - 0.000000002355 69.0
HKD2_k127_8986345_0 ATP-dependent Clp protease ATP-binding subunit ClpA K03694 - - 1.14e-277 873.0
HKD2_k127_8986345_1 UbiA prenyltransferase family K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 357.0
HKD2_k127_8986345_10 PFAM Amidohydrolase 2 K01686 - 4.2.1.8 0.00000000000000000000000000000000008483 147.0
HKD2_k127_8986345_11 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000000000000007239 126.0
HKD2_k127_8986345_12 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000003556 125.0
HKD2_k127_8986345_13 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000002917 83.0
HKD2_k127_8986345_14 Protein of unknown function (DUF2845) - - - 0.00000000001397 69.0
HKD2_k127_8986345_15 Domain of unknown function (DUF4136) - - - 0.000000000592 67.0
HKD2_k127_8986345_16 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000686 59.0
HKD2_k127_8986345_2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 322.0
HKD2_k127_8986345_3 leucyltransferase activity K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004058 299.0
HKD2_k127_8986345_4 FKBP-type peptidyl-prolyl cis-trans isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007588 297.0
HKD2_k127_8986345_5 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009766 285.0
HKD2_k127_8986345_6 TIGRFAM cytochrome C family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002331 276.0
HKD2_k127_8986345_7 Phospholipase D. Active site motifs. K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001044 274.0
HKD2_k127_8986345_8 SurA N-terminal domain K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000006233 227.0
HKD2_k127_8986345_9 Protein of unknown function (DUF4019) - - - 0.000000000000000000000000000000000000001564 151.0
HKD2_k127_8998312_0 His Kinase A (phospho-acceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 591.0
HKD2_k127_8998312_2 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K07713 - - 0.000000000000000000007799 95.0
HKD2_k127_9008695_0 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008307 605.0
HKD2_k127_9008695_1 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 341.0
HKD2_k127_9008695_2 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000000009118 201.0
HKD2_k127_9008695_3 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.0000000000000000000000000000000000000000000000000003744 189.0
HKD2_k127_9008695_4 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000000000001227 131.0
HKD2_k127_9008695_5 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000006118 112.0
HKD2_k127_9008695_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000011 82.0
HKD2_k127_9023776_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1165.0
HKD2_k127_9023776_1 myo-inosose-2 dehydratase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008125 317.0
HKD2_k127_9023776_2 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 304.0
HKD2_k127_9023776_3 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001373 285.0
HKD2_k127_9023776_4 ADP-ribosylation factor family K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000004624 242.0
HKD2_k127_9023776_5 - - - - 0.000000000000000000000000000000000000000000000000000000000002432 233.0
HKD2_k127_9023776_6 Putative regulatory protein - - - 0.000000000000000000001158 98.0
HKD2_k127_9023776_7 PFAM VacJ family lipoprotein K04754 - - 0.0000000000004846 75.0
HKD2_k127_9023776_8 LysM domain - - - 0.00000000003165 76.0
HKD2_k127_9047839_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 2.378e-262 820.0
HKD2_k127_9047839_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 524.0
HKD2_k127_9047839_2 Carbon-nitrogen hydrolase K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 493.0
HKD2_k127_9047839_3 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 417.0
HKD2_k127_9047839_4 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 335.0
HKD2_k127_9047839_5 SurA N-terminal domain K03771 - 5.2.1.8 0.00000000000000000000000005045 120.0
HKD2_k127_9047839_6 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00002482 55.0
HKD2_k127_9057175_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 345.0
HKD2_k127_9057175_1 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006984 245.0
HKD2_k127_9057175_2 molybdopterin binding domain - - - 0.00000000000000000005824 89.0
HKD2_k127_9057175_3 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000002317 69.0
HKD2_k127_9064145_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 546.0
HKD2_k127_9064145_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.0000000000000000000000000000000000003487 160.0
HKD2_k127_9064145_2 Universal stress protein - - - 0.0000004409 57.0
HKD2_k127_9064145_3 PFAM Universal stress protein family - - - 0.000004737 57.0
HKD2_k127_9064145_4 Universal stress protein - - - 0.00003634 54.0
HKD2_k127_9075428_0 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 301.0
HKD2_k127_9075428_1 ferredoxin-thioredoxin reductase activity - - - 0.0000000000000000000000000000000000000000003817 159.0
HKD2_k127_9075428_2 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676,K06191,K07390,K21636 - 1.1.98.6 0.000000000000000000001168 97.0
HKD2_k127_9075428_4 - - - - 0.0000002007 58.0
HKD2_k127_9075428_5 phosphorelay sensor kinase activity - - - 0.000003495 59.0
HKD2_k127_911246_0 Cytochrome C and Quinol oxidase polypeptide I K04561 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0016966,GO:0055114 1.7.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 425.0
HKD2_k127_911246_1 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 308.0
HKD2_k127_911246_2 PFAM Cytochrome b5 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001001 288.0
HKD2_k127_911246_3 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007078 249.0
HKD2_k127_911246_4 4Fe-4S binding domain - - - 0.000000000000000000000000000000000009346 148.0
HKD2_k127_911246_5 Cupin 2, conserved barrel domain protein - - - 0.0000000000006492 72.0
HKD2_k127_911246_6 Cytochrome b(C-terminal)/b6/petD K00412 - - 0.000000000000888 70.0
HKD2_k127_911246_7 electron transfer activity K05337,K17247 - - 0.000000009491 58.0
HKD2_k127_911246_8 - - - - 0.0001531 49.0
HKD2_k127_9122599_0 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001831 242.0
HKD2_k127_9122599_1 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.000000000000000000000000000000000000001966 149.0
HKD2_k127_9122599_2 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000000007331 121.0
HKD2_k127_9149214_0 PFAM Transketolase K00615 - 2.2.1.1 5.333e-238 747.0
HKD2_k127_9149214_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000001843 68.0
HKD2_k127_9161103_0 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 605.0
HKD2_k127_9161103_1 Actin K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009479 534.0
HKD2_k127_9161103_2 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 437.0
HKD2_k127_9161103_3 Cation efflux family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002204 273.0
HKD2_k127_9161103_4 AMP-binding enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004292 265.0
HKD2_k127_9161103_5 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000001223 143.0
HKD2_k127_9161103_6 Protein of unknown function (DUF1232) - - - 0.00000000000000000000000002453 110.0
HKD2_k127_9161103_7 shape-determining protein MreD K03571 - - 0.00006128 51.0
HKD2_k127_9192275_0 Binding-protein-dependent transport system inner membrane component K02050 - - 4.877e-231 727.0
HKD2_k127_9192275_1 ABC transporter K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 548.0
HKD2_k127_9192275_2 - - - - 0.00000000000000000000000000000000000001924 152.0
HKD2_k127_9192275_3 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.0000000000000000000001987 98.0
HKD2_k127_9205538_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 1.998e-225 710.0
HKD2_k127_9205538_1 TIGRFAM single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 442.0
HKD2_k127_9205538_10 - - - - 0.0006183 48.0
HKD2_k127_9205538_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 333.0
HKD2_k127_9205538_3 Psort location Cytoplasmic, score 8.96 K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001658 274.0
HKD2_k127_9205538_4 Methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000002521 267.0
HKD2_k127_9205538_5 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000005761 176.0
HKD2_k127_9205538_6 Preprotein translocase subunit K03210 - - 0.000000000000000000000000000000000009102 139.0
HKD2_k127_9205538_7 - - - - 0.0000000000000000000001054 109.0
HKD2_k127_9205538_8 Histidine kinase K07651 - 2.7.13.3 0.00000000000000000004767 91.0
HKD2_k127_9205538_9 - - - - 0.00000000002691 72.0
HKD2_k127_924403_0 TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain K02031,K02032,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 362.0
HKD2_k127_924403_1 Belongs to the ABC transporter superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000502 357.0
HKD2_k127_924403_2 Histidine kinase K07641,K07642,K07711 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000004648 213.0
HKD2_k127_924403_3 TPR repeat - - - 0.00000000000000000000000000000000000000000000000000004659 195.0
HKD2_k127_924403_4 Glutathione peroxidase - - - 0.000000000000000000000000000000000001099 145.0
HKD2_k127_924403_5 Belongs to the UPF0235 family K09131 - - 0.0000000000000003735 81.0
HKD2_k127_9244437_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 3.758e-221 697.0
HKD2_k127_9244437_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000008283 134.0
HKD2_k127_9287047_0 Belongs to the thiolase family K00626 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007761 530.0
HKD2_k127_9287047_1 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.0000000000000000000000000000000000000000000000000000000000009761 219.0
HKD2_k127_9287047_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000005461 145.0
HKD2_k127_9287047_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000001031 124.0
HKD2_k127_9287080_0 phosphorelay signal transduction system K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 424.0
HKD2_k127_9287080_1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008119 379.0
HKD2_k127_9287080_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 361.0
HKD2_k127_9287080_3 Belongs to the acetyltransferase family. ArgA subfamily K00619,K14681 GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000002225 223.0
HKD2_k127_9287080_4 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000008255 234.0
HKD2_k127_9287080_5 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000001631 207.0
HKD2_k127_9287080_6 oxidoreductase gamma subunit K00177 - 1.2.7.3 0.000000000000000000000000000000000000000188 156.0
HKD2_k127_9287080_7 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.00006017 53.0
HKD2_k127_9289964_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 3.552e-238 746.0
HKD2_k127_9289964_1 Preprotein translocase SecG subunit K03075 - - 0.000000000000000001471 90.0
HKD2_k127_9289964_2 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus K03821 - - 0.000000000000004942 77.0
HKD2_k127_9331055_0 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006957 320.0
HKD2_k127_9331055_1 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000001848 243.0
HKD2_k127_9331055_2 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000000000006838 229.0
HKD2_k127_9331055_3 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000003315 178.0
HKD2_k127_9331055_4 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.000000000000000000000000000002963 123.0
HKD2_k127_9331055_5 PFAM ABC transporter K01990 - - 0.00002038 50.0
HKD2_k127_9352916_0 ATPase BadF BadG BcrA BcrD type - - - 0.0 1559.0
HKD2_k127_9352916_1 7TM receptor with intracellular HD hydrolase K07037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 501.0
HKD2_k127_9352916_10 Prokaryotic diacylglycerol kinase K00901 - 2.7.1.107 0.00000000000000000000000000000000000000000000000004815 186.0
HKD2_k127_9352916_11 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000005105 98.0
HKD2_k127_9352916_12 Protein of unknown function (DUF2905) - - - 0.0000000000000000002296 93.0
HKD2_k127_9352916_13 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.000000000000001956 77.0
HKD2_k127_9352916_15 - - - - 0.000000002956 64.0
HKD2_k127_9352916_16 Lipoprotein - - - 0.000009172 57.0
HKD2_k127_9352916_2 Na dependent nucleoside transporter K03317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 409.0
HKD2_k127_9352916_3 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005902 394.0
HKD2_k127_9352916_4 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006316 347.0
HKD2_k127_9352916_5 Stage II sporulation protein K06381 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 310.0
HKD2_k127_9352916_6 Transcriptional regulator K11921,K19338 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007239 303.0
HKD2_k127_9352916_7 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000002328 225.0
HKD2_k127_9352916_8 queuosine biosynthetic process K03470,K09765 - 1.17.99.6,3.1.26.4 0.00000000000000000000000000000000000000000000000000000003378 201.0
HKD2_k127_9352916_9 - - - - 0.000000000000000000000000000000000000000000000000000004334 196.0
HKD2_k127_9357031_0 Aminotransferase class-III K01845 - 5.4.3.8 8.74e-206 647.0
HKD2_k127_9357031_1 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 596.0
HKD2_k127_9357031_10 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000003597 258.0
HKD2_k127_9357031_11 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000799 228.0
HKD2_k127_9357031_12 Putative zinc- or iron-chelating domain - - - 0.000000000000000000000000000000000000000000000000000462 191.0
HKD2_k127_9357031_13 heat shock protein binding - - - 0.00000000000000000000000000000000000007379 154.0
HKD2_k127_9357031_14 heat shock protein binding - - - 0.0000000000000000000000000000000000622 146.0
HKD2_k127_9357031_17 Cytochrome c - - - 0.00000000000000000000002689 103.0
HKD2_k127_9357031_2 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 596.0
HKD2_k127_9357031_3 Ribosomal protein S1-like RNA-binding domain K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 577.0
HKD2_k127_9357031_4 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009001 465.0
HKD2_k127_9357031_5 glucan 1,4-alpha-glucosidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 428.0
HKD2_k127_9357031_6 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 421.0
HKD2_k127_9357031_7 ribonuclease BN K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002111 361.0
HKD2_k127_9357031_8 thymidylate synthase (FAD) activity K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 326.0
HKD2_k127_9357031_9 PFAM oxidoreductase, molybdopterin binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004408 285.0
HKD2_k127_9373752_0 Malate/L-lactate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009237 531.0
HKD2_k127_9373752_1 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454,K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004984 527.0
HKD2_k127_9373752_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 477.0
HKD2_k127_9373752_3 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000000000000000000000002947 223.0
HKD2_k127_9373752_5 PFAM response regulator receiver K03413 - - 0.0000001378 54.0
HKD2_k127_9399573_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1184.0
HKD2_k127_9399573_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 1.399e-212 676.0
HKD2_k127_9399573_10 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005247 252.0
HKD2_k127_9399573_11 PFAM Roadblock LC7 family protein - - - 0.000000000000000000000000000000000000000000000000000000000001028 213.0
HKD2_k127_9399573_12 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000000000002946 131.0
HKD2_k127_9399573_13 PFAM Carboxymuconolactone decarboxylase - - - 0.00000000000000000000000000005537 119.0
HKD2_k127_9399573_14 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.00000000000000000002014 101.0
HKD2_k127_9399573_15 Rubrerythrin - - - 0.000000000000008907 80.0
HKD2_k127_9399573_2 isocitrate dehydrogenase activity K00031 GO:0000287,GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006102,GO:0008150,GO:0008152,GO:0008270,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044464,GO:0045333,GO:0046487,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:0072350 1.1.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 569.0
HKD2_k127_9399573_3 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 481.0
HKD2_k127_9399573_4 PFAM Hemerythrin HHE cation binding domain K09155 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 485.0
HKD2_k127_9399573_5 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006988 372.0
HKD2_k127_9399573_6 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 353.0
HKD2_k127_9399573_7 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008328 319.0
HKD2_k127_9399573_8 Inositol monophosphatase family K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003796 289.0
HKD2_k127_9399573_9 HD domain K07023 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005843 280.0
HKD2_k127_9426649_0 amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 317.0
HKD2_k127_9426649_1 aminopeptidase N - - - 0.0000000000000000000000000000000000000000000000000000003016 205.0
HKD2_k127_9426649_2 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000006502 198.0
HKD2_k127_9426649_3 DNA-binding transcription factor activity K02274 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000007496 193.0
HKD2_k127_9439801_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 - 1.12.99.6 1.165e-236 740.0
HKD2_k127_9439801_1 Endoribonuclease that initiates mRNA decay K18682 - - 1.117e-207 658.0
HKD2_k127_9439801_10 OsmC-like protein K07397 - - 0.0000000000000000000000000000000000000000000000000000003086 196.0
HKD2_k127_9439801_11 Hydrogenase maturation protease K03605 - - 0.0000000000000000000000000000000000000000000001955 174.0
HKD2_k127_9439801_12 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000009018 146.0
HKD2_k127_9439801_13 Belongs to the CinA family K03742,K03743 - 3.5.1.42 0.000000000000000000000000000002733 126.0
HKD2_k127_9439801_14 Phosphatidylglycerophosphatase A K01095 - 3.1.3.27 0.000000000000000000000000000002837 125.0
HKD2_k127_9439801_15 Large subunit K06281 - 1.12.99.6 0.000000000000000000000001309 103.0
HKD2_k127_9439801_16 - - - - 0.0000000000000000000002368 98.0
HKD2_k127_9439801_17 - - - - 0.00000000001582 67.0
HKD2_k127_9439801_18 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.0000000001615 65.0
HKD2_k127_9439801_2 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 516.0
HKD2_k127_9439801_3 PFAM type II secretion system protein E K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004427 498.0
HKD2_k127_9439801_4 NiFe/NiFeSe hydrogenase small subunit C-terminal K06282 - 1.12.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007705 436.0
HKD2_k127_9439801_5 Metallo-beta-lactamase superfamily K06897 - 2.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 331.0
HKD2_k127_9439801_6 PFAM Metallophosphoesterase K09769 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 321.0
HKD2_k127_9439801_7 Memo-like protein K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 289.0
HKD2_k127_9439801_8 Domain of unknown function (DUF4405) - - - 0.00000000000000000000000000000000000000000000000000000000002454 212.0
HKD2_k127_9439801_9 prenyltransferase activity K03186,K16875 GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.129 0.000000000000000000000000000000000000000000000000000000002579 205.0
HKD2_k127_9485187_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002483 323.0
HKD2_k127_9485187_1 denitrification pathway - - - 0.0000000000000000000000000000000000000000000000000000000000000000002137 237.0
HKD2_k127_9485187_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000003564 180.0
HKD2_k127_957786_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008377 475.0
HKD2_k127_957786_1 aminopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 404.0
HKD2_k127_957786_2 CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000000000000000000006937 130.0
HKD2_k127_96180_0 HI0933-like protein K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 459.0
HKD2_k127_96180_1 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000006601 180.0
HKD2_k127_96180_2 PFAM Peptidase family M28 - - - 0.0000000000000000000000000000000000001576 147.0
HKD2_k127_96180_3 septum formation protein Maf K06287 GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0022402,GO:0022607,GO:0030428,GO:0032506,GO:0044085,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0090529,GO:1902410,GO:1903047 - 0.00000000000000000001176 94.0
HKD2_k127_9622162_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003056 572.0
HKD2_k127_9622162_1 phosphatase activity K05967 - - 0.0000000000000000000000000000000000001299 154.0
HKD2_k127_9622162_3 Peptidase S24-like K01356 - 3.4.21.88 0.00001865 53.0
HKD2_k127_9642978_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 1.272e-277 874.0
HKD2_k127_9642978_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 6.358e-231 745.0
HKD2_k127_9642978_10 Histidine kinase K07675 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000001764 267.0
HKD2_k127_9642978_11 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000004704 252.0
HKD2_k127_9642978_12 FmdE, Molybdenum formylmethanofuran dehydrogenase operon K11261 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000552 245.0
HKD2_k127_9642978_13 Protein similar to CwfJ C-terminus 1 K19710 - 2.7.7.53 0.00000000000000000000000000000000000000000000000000000000000006401 218.0
HKD2_k127_9642978_14 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000793 222.0
HKD2_k127_9642978_15 regulation of ruffle assembly - - - 0.000000000000000000000000000000000000000000000000000000000001222 217.0
HKD2_k127_9642978_16 phosphorelay signal transduction system - - - 0.000000000000000000000000000000000000000000000000000009308 194.0
HKD2_k127_9642978_17 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000000000000000000000000003059 193.0
HKD2_k127_9642978_18 Prokaryotic N-terminal methylation motif K02456 - - 0.0000000000000000000000000000000000000000000000000005773 187.0
HKD2_k127_9642978_19 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000000005835 173.0
HKD2_k127_9642978_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 494.0
HKD2_k127_9642978_20 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.00000000000000000000000000000000000000000006424 162.0
HKD2_k127_9642978_21 PAC sensor-containing diguanylate cyclase - - - 0.00000000000000000000000000000000000000007261 165.0
HKD2_k127_9642978_22 Universal stress protein family - - - 0.0000000000000000000000000000000000004619 145.0
HKD2_k127_9642978_23 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000001912 139.0
HKD2_k127_9642978_24 ATPase or kinase K06925 GO:0002949,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000000000000000001872 123.0
HKD2_k127_9642978_25 YCII-related domain - - - 0.000000000000000000000000001232 116.0
HKD2_k127_9642978_26 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.000000000000000000000000008488 123.0
HKD2_k127_9642978_27 iron-sulfur cluster assembly - - - 0.000000000000000000000005181 102.0
HKD2_k127_9642978_28 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000000008128 105.0
HKD2_k127_9642978_29 Peptidase C26 K07010 - - 0.0000000000000000001405 91.0
HKD2_k127_9642978_3 N-Acyl-D-aspartate D-glutamate deacylase K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 481.0
HKD2_k127_9642978_30 Psort location CytoplasmicMembrane, score K09153 - - 0.000000000000007747 80.0
HKD2_k127_9642978_31 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000002222 69.0
HKD2_k127_9642978_32 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K16785 - - 0.00000001906 63.0
HKD2_k127_9642978_4 Probable molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 417.0
HKD2_k127_9642978_5 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006413 341.0
HKD2_k127_9642978_6 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003212 314.0
HKD2_k127_9642978_7 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 312.0
HKD2_k127_9642978_8 COG0564 Pseudouridylate synthases, 23S RNA-specific K06177 - 5.4.99.28,5.4.99.29 0.000000000000000000000000000000000000000000000000000000000000000000000000005298 261.0
HKD2_k127_9642978_9 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000008519 252.0
HKD2_k127_9765812_0 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 434.0
HKD2_k127_9765812_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002089 262.0
HKD2_k127_9765812_10 Phosphoesterase family - - - 0.00004627 55.0
HKD2_k127_9765812_2 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003,K05685 - - 0.00000000000000000000000000000000000000000000000000000002234 203.0
HKD2_k127_9765812_3 Putative transmembrane protein (Alph_Pro_TM) - - - 0.0000000000000000000000000000000000000000000000291 180.0
HKD2_k127_9765812_4 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000000000000000000111 134.0
HKD2_k127_9765812_5 Tetratricopeptide repeat - - - 0.00000000000000009385 89.0
HKD2_k127_9765812_6 AMP binding - - - 0.0000000001466 67.0
HKD2_k127_9765812_7 NosL K19342 - - 0.000000000791 66.0
HKD2_k127_9765812_9 Type II/IV secretion system protein K02454,K02652 - - 0.00001324 50.0
HKD2_k127_9809260_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 325.0
HKD2_k127_9809260_1 ACT domain K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000001632 256.0
HKD2_k127_9809260_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000001475 234.0
HKD2_k127_9809260_3 helix_turn_helix, cAMP Regulatory protein - - - 0.000000000000000000000000000000000000000000000000000000007807 205.0
HKD2_k127_9809260_4 BON domain - - - 0.000000000000000000000002507 110.0
HKD2_k127_9809260_5 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000006852 98.0
HKD2_k127_9813636_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 312.0
HKD2_k127_9813636_1 TGS domain K06944 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 305.0
HKD2_k127_9813636_2 DNA alkylation repair enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000838 267.0
HKD2_k127_9813636_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000005123 232.0
HKD2_k127_9818737_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1038.0
HKD2_k127_9818737_1 Gram-negative-bacterium-type cell outer membrane assembly K04064,K06186 GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896 - 0.0000000000000000000000000009166 115.0
HKD2_k127_9818737_2 Regulatory protein RecX K03565 - - 0.0000000001738 67.0
HKD2_k127_9946273_0 PD-(D/E)XK nuclease superfamily - - - 2.448e-243 786.0
HKD2_k127_9946273_1 Belongs to the helicase family. UvrD subfamily - - - 1.098e-219 713.0
HKD2_k127_9946273_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008429 474.0
HKD2_k127_9946273_3 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 455.0
HKD2_k127_9946273_4 Sigma-54 interaction domain K02481,K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 425.0
HKD2_k127_9946273_5 Amino acid adenylation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001418 277.0
HKD2_k127_9946273_6 zinc ion binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005028 252.0
HKD2_k127_9946273_7 GAF domain K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000007358 265.0
HKD2_k127_9946273_8 Belongs to the P-Pant transferase superfamily K06133 - - 0.000000000000000000000000000000000000000000000000000000007397 207.0
HKD2_k127_9946273_9 Tetratricopeptide TPR_2 repeat protein - - - 0.0001582 52.0
HKD2_k127_9960050_0 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008411 555.0
HKD2_k127_9960050_1 diaminopimelate decarboxylase activity K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000809 526.0
HKD2_k127_9960050_2 spermidine synthase activity K00797 GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007922 437.0
HKD2_k127_9960050_3 Starch synthase catalytic domain K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 429.0
HKD2_k127_9960050_4 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 429.0
HKD2_k127_9960050_5 tRNA 3'-trailer cleavage K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008339 328.0
HKD2_k127_9960050_6 COGs COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain) K01768 - 4.6.1.1 0.0003205 54.0
HKD2_k127_9965225_0 PFAM FAD linked oxidase domain protein - - - 1.49e-261 811.0
HKD2_k127_9965225_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007545 526.0
HKD2_k127_9965225_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 439.0
HKD2_k127_9965225_3 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 394.0
HKD2_k127_9965225_4 Desulfoferrodoxin ferrous iron-binding K05919 - 1.15.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000024 241.0
HKD2_k127_9965225_5 Protein of unknown function (DUF1810) - - - 0.000000000000000000000000000000000000000000000000000001047 195.0
HKD2_k127_9965225_6 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.00000000000000000000000000000000000000000003594 164.0
HKD2_k127_9965225_7 Threonyl-tRNA synthetase - - - 0.000000000000000000000000009049 111.0
HKD2_k127_9965225_8 cheY-homologous receiver domain - - - 0.000000004702 67.0