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Overview

ID MAG01779
Name HKD2_bin.2
Sample SMP0047
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanomicrobia
Order Methanomicrobiales
Family JACTUA01
Genus JAJRCY01
Species
Assembly information
Completeness (%) 63.48
Contamination (%) 2.62
GC content (%) 64.0
N50 (bp) 2,445
Genome size (bp) 1,355,540

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1628

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10001047_0 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 482.0
HKD2_k127_10015094_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 6.526e-237 746.0
HKD2_k127_10015094_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005027 335.0
HKD2_k127_10015094_2 membrane K09167 - - 0.0000000000000000000000000000000000000000000000000000000000003562 216.0
HKD2_k127_10015094_3 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000007588 158.0
HKD2_k127_1002436_0 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002258 263.0
HKD2_k127_1002436_1 ABC transporter K02049 - - 0.00000000000000000000000000000000000000000000000000000000000003006 232.0
HKD2_k127_1002436_2 NMT1-like family K02051 - - 0.0000000000000000000000000000000000000000000001135 182.0
HKD2_k127_1002436_3 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.0000000000000000000000000000000000000000000003523 168.0
HKD2_k127_10034863_0 V-type ATP synthase, subunit I K02123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004464 328.0
HKD2_k127_10034863_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009511 249.0
HKD2_k127_10034863_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000000000000000001629 175.0
HKD2_k127_10068122_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 3.233e-243 757.0
HKD2_k127_10068122_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 568.0
HKD2_k127_10068122_2 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004915 458.0
HKD2_k127_10068122_3 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005526 416.0
HKD2_k127_10068122_4 Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids K00869 - 2.7.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 391.0
HKD2_k127_10068122_5 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003592 349.0
HKD2_k127_10068122_6 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007039 343.0
HKD2_k127_10068122_7 Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids K06981 - 2.7.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001686 281.0
HKD2_k127_10068122_8 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000006646 60.0
HKD2_k127_1007737_0 PFAM Protein kinase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004624 246.0
HKD2_k127_1007737_1 Pectinesterase - - - 0.000000000000000000000000000000000000000000000002498 192.0
HKD2_k127_1007737_2 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000000000000000001416 103.0
HKD2_k127_10192718_0 PD-(D/E)XK nuclease superfamily K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 326.0
HKD2_k127_10193919_0 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003328 421.0
HKD2_k127_10193919_1 Peptidase family M54 K06974 - - 0.0000000000000000000000000000000000003157 148.0
HKD2_k127_10193919_2 HEPN domain - - - 0.00000005188 61.0
HKD2_k127_1056239_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 1.922e-245 787.0
HKD2_k127_1056239_1 methanogenesis marker protein 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 452.0
HKD2_k127_1056239_2 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 411.0
HKD2_k127_1056239_3 Uncharacterized protein conserved in archaea (DUF2113) - - - 0.000000000000000000000000000000000000000000000000000000000000000005868 236.0
HKD2_k127_1056239_4 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.000000000000000000000000000000000000000000000000007174 184.0
HKD2_k127_106577_0 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 476.0
HKD2_k127_1066131_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000003346 217.0
HKD2_k127_1074431_0 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 431.0
HKD2_k127_1074431_1 transferase hexapeptide repeat containing protein K00966 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 420.0
HKD2_k127_1074431_2 archaeal Zn-finger protein - - - 0.00000000000000000000000000000000000000000000000000001136 194.0
HKD2_k127_1074431_3 Domain of unknown function (DUF371) K09738 - - 0.00000000000000000000000000000000000000000001591 164.0
HKD2_k127_1074431_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000001439 162.0
HKD2_k127_1074431_5 Thioredoxin K03671 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000008149 108.0
HKD2_k127_1074431_6 - - - - 0.000000000000000000000558 105.0
HKD2_k127_1097273_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 338.0
HKD2_k127_1101602_0 membrane-associated protein domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008092 268.0
HKD2_k127_1101602_1 Ig-like domain from next to BRCA1 gene - - - 0.00000000000000000000000000000000000000000000000000000001551 210.0
HKD2_k127_1101602_2 - - - - 0.0000000001028 72.0
HKD2_k127_1101602_3 Belongs to the glycosyl hydrolase 18 family - - - 0.000007137 57.0
HKD2_k127_1101602_4 reverse transcriptase - - - 0.0003777 48.0
HKD2_k127_1107454_0 Belongs to the eukaryotic ribosomal protein eS4 family K02987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 305.0
HKD2_k127_1107454_1 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000001394 236.0
HKD2_k127_1107454_2 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000000000000001949 222.0
HKD2_k127_1107454_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.0000000000000000000000000000000000000000000000000000000006447 207.0
HKD2_k127_1107454_4 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 - - 0.00000000000000000000000000000000000000002163 155.0
HKD2_k127_1107454_5 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000002566 151.0
HKD2_k127_1107454_6 Binds 16S rRNA, required for the assembly of 30S particles K02954 - - 0.00000000000000000000001628 100.0
HKD2_k127_1115972_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 419.0
HKD2_k127_1115972_1 PFAM AMMECR1 domain protein K09141 - - 0.00000000000000000000000001417 109.0
HKD2_k127_1121118_0 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009148 262.0
HKD2_k127_1121118_1 protein conserved in archaea - - - 0.00000000000007797 73.0
HKD2_k127_1121317_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 5.469e-216 673.0
HKD2_k127_1121317_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000001069 71.0
HKD2_k127_1126969_0 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001017 275.0
HKD2_k127_1126969_1 cyclase family K07130 - 3.5.1.9 0.000000000001202 73.0
HKD2_k127_1133711_0 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006111 394.0
HKD2_k127_1133711_1 Domain of unknown function (DUF814) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 324.0
HKD2_k127_1134480_0 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000000000000000000000000000000001934 246.0
HKD2_k127_1134480_1 - - - - 0.00000000000002852 78.0
HKD2_k127_1134480_2 ATP-grasp domain K06913 - - 0.0000000000001284 72.0
HKD2_k127_1139340_0 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 524.0
HKD2_k127_1139340_1 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007834 431.0
HKD2_k127_1139340_2 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.000007682 55.0
HKD2_k127_1171070_0 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 1e-238 760.0
HKD2_k127_1171070_1 MoeA C-terminal region (domain IV) K03750 - 2.10.1.1 0.00000000000000000000000000000000006566 138.0
HKD2_k127_1203465_0 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000000000000000000000000000000000000000000000000002994 216.0
HKD2_k127_1203465_1 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.0000000000000000000000533 98.0
HKD2_k127_1203465_2 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000001872 49.0
HKD2_k127_1208872_0 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 476.0
HKD2_k127_1235669_0 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014,K00891,K03785 - 1.1.1.25,2.7.1.71,4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 327.0
HKD2_k127_1235669_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000003496 72.0
HKD2_k127_1240174_0 PFAM Radical SAM domain protein K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000856 514.0
HKD2_k127_1240174_1 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002286 280.0
HKD2_k127_1281187_0 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002721 354.0
HKD2_k127_1281187_1 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000001215 163.0
HKD2_k127_131045_0 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.000000000000000000000000000000000000000000000000000000000000002217 224.0
HKD2_k127_131045_1 PFAM metal-dependent phosphohydrolase, HD sub domain K06950 - - 0.00000000000000000000000000000000000000000001471 167.0
HKD2_k127_131045_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07709 - 2.7.13.3 0.00000000000000000000000000000000003569 141.0
HKD2_k127_131045_3 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.000000000007779 66.0
HKD2_k127_132512_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 427.0
HKD2_k127_132512_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002378 278.0
HKD2_k127_132512_2 PFAM ABC-2 type transporter K01992 - - 0.0000000000001942 72.0
HKD2_k127_1373942_0 - - - - 0.0000000000000000000000000000000000000625 149.0
HKD2_k127_1373942_1 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000000000000000000000000004263 124.0
HKD2_k127_1373942_2 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.0000002875 54.0
HKD2_k127_1391932_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003027 443.0
HKD2_k127_1391932_1 PFAM AIR synthase related protein K07123 - - 0.000000000000000000000000000000000000000000000000000000000000000002701 229.0
HKD2_k127_1393759_0 PFAM Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009137 458.0
HKD2_k127_1404212_0 PFAM HhH-GPD family protein K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001065 282.0
HKD2_k127_1404212_1 PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002764 244.0
HKD2_k127_1404212_2 NmrA-like family K01784 - 5.1.3.2 0.00000000000000008308 82.0
HKD2_k127_1404212_3 - - - - 0.00000000000001974 79.0
HKD2_k127_1421161_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 541.0
HKD2_k127_1437178_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 347.0
HKD2_k127_1437178_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000001865 160.0
HKD2_k127_1439340_0 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 291.0
HKD2_k127_1439340_1 Cobalt transport protein K02008 - - 0.0000000000000000000000000000000000000000000000000000000005557 212.0
HKD2_k127_1439340_2 iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000003418 160.0
HKD2_k127_1441066_0 Cytochrome c-type biogenesis protein CcmF C-terminal K02198 - - 0.000000000000000000000000000000000000000000000000000000000826 224.0
HKD2_k127_1441066_1 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH - - - 0.0000002848 56.0
HKD2_k127_1442456_0 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003966 245.0
HKD2_k127_1442456_1 PFAM HhH-GPD family protein K03575 - - 0.0000000000000000000000000000000001251 136.0
HKD2_k127_1446939_0 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006074 275.0
HKD2_k127_1446939_1 Protein of unknown function (DUF473) K09135 - - 0.00000000000000000000000000000000000002287 149.0
HKD2_k127_147942_0 L-lactate dehydrogenase (FMN-dependent) and related alpha-hydroxy acid dehydrogenases K00467 - 1.13.12.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 545.0
HKD2_k127_147942_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002876 366.0
HKD2_k127_147942_2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000001486 171.0
HKD2_k127_147942_3 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.00001954 53.0
HKD2_k127_1573627_0 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 302.0
HKD2_k127_1573627_1 CBS domain containing protein - - - 0.0000007365 52.0
HKD2_k127_1608221_0 Belongs to the peptidase S8 family K01342 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030193,GO:0030195,GO:0032101,GO:0032102,GO:0042730,GO:0043170,GO:0044238,GO:0048519,GO:0048583,GO:0048585,GO:0050789,GO:0050818,GO:0050819,GO:0050878,GO:0051239,GO:0051241,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070011,GO:0071704,GO:0080134,GO:0140096,GO:1900046,GO:1900047,GO:1901564,GO:1903034,GO:1903035 3.4.21.62 0.000000000000000000000000000000000000000008432 166.0
HKD2_k127_1616296_0 - - - - 0.00000000000005558 84.0
HKD2_k127_1675669_0 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004801 331.0
HKD2_k127_1675669_1 Protein phosphatase 2C - - - 0.00000001634 57.0
HKD2_k127_1675669_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.00000108 53.0
HKD2_k127_1681735_0 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000000000000000004388 162.0
HKD2_k127_1681735_1 - - - - 0.000000000000000000000000000000000000001024 153.0
HKD2_k127_1681735_2 TIGRFAM hydrogenase assembly chaperone hypC hupF K04653 - - 0.000000000000000000000000000000006594 131.0
HKD2_k127_1681735_3 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.000000000000001992 79.0
HKD2_k127_1683847_0 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005413 407.0
HKD2_k127_1683847_1 methyltransferase small K07579 - - 0.0000000000000000000000000000000000000000000000000000000000000139 226.0
HKD2_k127_1683847_2 PFAM major facilitator superfamily MFS_1 K08223 - - 0.000000000000000000000000000000002475 134.0
HKD2_k127_1683847_3 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000001286 86.0
HKD2_k127_1706540_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000459 541.0
HKD2_k127_1706540_1 - - - - 0.000000000000000000000000000008425 123.0
HKD2_k127_1718289_0 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 383.0
HKD2_k127_1718289_1 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000003964 173.0
HKD2_k127_1718289_2 - - - - 0.000000000000000000000000000000005056 130.0
HKD2_k127_1718289_3 but it may be involved in stabilization of the trimeric complex - - - 0.00000000000003974 73.0
HKD2_k127_1718289_4 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.00000000000306 72.0
HKD2_k127_1737123_0 cytidyltransferase-related domain K00952 - 2.7.7.1 0.0000000000000000000000000000000000000000000000001383 177.0
HKD2_k127_1737123_1 Transglutaminase-like superfamily - - - 0.0000000000000000000000002441 116.0
HKD2_k127_174713_0 Sodium hydrogen exchanger K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003488 247.0
HKD2_k127_174713_1 Protein of unknown function DUF45 K07043 - - 0.00000000001355 76.0
HKD2_k127_1765386_0 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 518.0
HKD2_k127_1765386_1 PFAM tRNA methyltransferase complex GCD14 subunit K07442 - 2.1.1.219,2.1.1.220 0.00000000000000000000000000000000000000000000000000000000000000000000000002735 259.0
HKD2_k127_1765386_2 Contacts the emerging nascent chain on the ribosome K03626 - - 0.0000000000000000000000000000000000001961 143.0
HKD2_k127_1765386_3 PFAM PUA domain containing protein K07398 - - 0.0000000000000000000000000000004532 132.0
HKD2_k127_176704_0 Required for chromosome condensation and partitioning K03529 - - 5.257e-304 962.0
HKD2_k127_176704_1 chromosome segregation and condensation protein ScpA K05896 - - 0.000000000000000000000000000000005023 132.0
HKD2_k127_1776294_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 411.0
HKD2_k127_1776294_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.00000000001444 67.0
HKD2_k127_1799177_0 2Fe-2S iron-sulfur cluster binding domain - - - 1.129e-246 769.0
HKD2_k127_1799177_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 494.0
HKD2_k127_1819039_0 serine-type endopeptidase activity - - - 0.0000000000000000000000000000000000000000000001807 172.0
HKD2_k127_1819039_1 Uracil DNA glycosylase superfamily K03649 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097507,GO:0140097,GO:1901360 3.2.2.28 0.0000000000000000000000000000000000000001424 155.0
HKD2_k127_1819039_2 PFAM Polyketide cyclase dehydrase - - - 0.00006446 52.0
HKD2_k127_1847685_0 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 370.0
HKD2_k127_1847685_1 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.000000000000000000000000000000000000000000000001379 184.0
HKD2_k127_1847685_2 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain K07746 - - 0.0000000000000000000000533 98.0
HKD2_k127_1847685_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00001072 49.0
HKD2_k127_1865125_0 SMART Elongator protein 3 MiaB NifB - - - 5.159e-237 747.0
HKD2_k127_1865125_1 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.000000000000000000000000000000000000000000000006263 173.0
HKD2_k127_1889000_0 KH, type 1, domain K07041 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 595.0
HKD2_k127_1889000_1 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000001635 123.0
HKD2_k127_1891866_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005341 443.0
HKD2_k127_1891866_1 PBP superfamily domain K05772 - - 0.00000000000006255 74.0
HKD2_k127_1948447_0 PFAM aminotransferase class V - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 364.0
HKD2_k127_1953896_0 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 432.0
HKD2_k127_2004204_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007497 500.0
HKD2_k127_2004204_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 338.0
HKD2_k127_2004204_2 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000296 181.0
HKD2_k127_2004204_3 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000846 117.0
HKD2_k127_2009779_0 Methanogenesis marker protein 8 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 317.0
HKD2_k127_2009779_1 Protein of unknown function (DUF1624) - - - 0.00000000000000000000001836 105.0
HKD2_k127_2009779_2 Sugar efflux transporter for intercellular exchange K15383 - - 0.0000000000000000000193 93.0
HKD2_k127_2037673_0 Belongs to the UPF0288 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007956 442.0
HKD2_k127_2037673_1 Uncharacterized protein conserved in archaea (DUF2102) - - - 0.000000000000000000000000000000000000000000003321 175.0
HKD2_k127_2052118_0 Trehalose utilisation - - - 0.000000000000000002097 89.0
HKD2_k127_2052118_1 - K03561,K12287 - - 0.00000000000004354 81.0
HKD2_k127_2072184_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 4.317e-260 806.0
HKD2_k127_2072184_1 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 323.0
HKD2_k127_2083701_0 PFAM peptidase U32 K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 338.0
HKD2_k127_2099315_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 361.0
HKD2_k127_2099315_1 PFAM Chromate transporter K07240 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008017 277.0
HKD2_k127_210726_0 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006369 394.0
HKD2_k127_210726_1 PFAM methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 349.0
HKD2_k127_2112183_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 7.466e-281 878.0
HKD2_k127_2112183_1 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007641 397.0
HKD2_k127_2112183_2 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.00000000000000000000000000000000000000002847 155.0
HKD2_k127_2118972_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 3.008e-275 860.0
HKD2_k127_2145742_0 UDP-glucose:hexose-1-phosphate uridylyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 363.0
HKD2_k127_2154600_0 PFAM Histone deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 355.0
HKD2_k127_2154600_1 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000002352 123.0
HKD2_k127_2161463_0 Nitrogenase component 1 type Oxidoreductase K02587 - - 2.712e-234 730.0
HKD2_k127_2176515_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 2.427e-205 647.0
HKD2_k127_2177394_0 Belongs to the TPP enzyme family K00158 - 1.2.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002904 458.0
HKD2_k127_2177394_1 4-Hydroxyphenylpyruvate dioxygenase - - - 0.0000000000000000000000000000000001271 139.0
HKD2_k127_2179361_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 378.0
HKD2_k127_2179361_1 COG1361 S-layer domain - - - 0.000000000000000000000000000000000000000000000000000001033 199.0
HKD2_k127_2179361_2 PFAM Cation K03498 - - 0.00000000000000001615 91.0
HKD2_k127_2198843_0 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009281 263.0
HKD2_k127_2198843_1 metallopeptidase activity - - - 0.000000000000000000000000000000009536 133.0
HKD2_k127_2204425_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001772 455.0
HKD2_k127_2204425_1 COG0477 Permeases of the major facilitator superfamily K08177 - - 0.00000000000000000000000000000000000000000005512 161.0
HKD2_k127_2223476_0 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000003744 189.0
HKD2_k127_2223476_1 PFAM cyclase family protein K07130 - 3.5.1.9 0.0000000000000000000000000000000000000005341 153.0
HKD2_k127_2226337_0 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007196 375.0
HKD2_k127_2226337_1 Peptidase C39 family K06992 - - 0.000000000000000000000000006285 115.0
HKD2_k127_2229317_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 2.238e-261 811.0
HKD2_k127_2258971_0 PFAM Aminotransferase class I and II K10907 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 568.0
HKD2_k127_2258971_1 PFAM regulatory protein AsnC Lrp family - - - 0.00000000000000000000000000000000000000000000000000294 183.0
HKD2_k127_2264918_0 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 420.0
HKD2_k127_2264918_1 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000006914 209.0
HKD2_k127_2269890_0 SMART Elongator protein 3 MiaB NifB K06936 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009261 398.0
HKD2_k127_2269890_1 - - - - 0.0000000000000000000000003294 121.0
HKD2_k127_2276184_0 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001669 259.0
HKD2_k127_2276184_1 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000009198 102.0
HKD2_k127_2282544_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000000000000000000000000003155 160.0
HKD2_k127_2282544_1 COG2041 Sulfite oxidase and related enzymes - - - 0.00000001249 59.0
HKD2_k127_2291398_0 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008267 454.0
HKD2_k127_2291398_1 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000973 268.0
HKD2_k127_2291398_2 PDGLE domain K02009 - - 0.0000000000000000000001286 103.0
HKD2_k127_2291398_3 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000001033 71.0
HKD2_k127_2291398_4 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.000000000002945 68.0
HKD2_k127_2293326_0 Trypsin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009286 418.0
HKD2_k127_2293326_1 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000000000000000001709 186.0
HKD2_k127_2293326_2 AraC-like ligand binding domain - - - 0.00000000000000000000006869 104.0
HKD2_k127_2297329_0 DEAD DEAH box helicase domain protein K03725 - - 2.007e-256 807.0
HKD2_k127_2297329_1 SMART regulatory protein, Crp K07730 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 394.0
HKD2_k127_2297329_2 ArsR transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000002477 227.0
HKD2_k127_2297329_3 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.000000000000000000000000001464 113.0
HKD2_k127_2383942_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 555.0
HKD2_k127_2383942_1 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 363.0
HKD2_k127_2383942_2 COG0433 Predicted ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007414 268.0
HKD2_k127_2383942_3 MoaE protein K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000000000000000000000000000002709 243.0
HKD2_k127_2391110_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006081 354.0
HKD2_k127_2391110_1 COG1413 FOG HEAT repeat K22221 - - 0.0001959 47.0
HKD2_k127_2427409_0 Succinate dehydrogenase fumarate reductase flavoprotein subunit K00239,K18209 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016491,GO:0022900,GO:0044237,GO:0045333,GO:0055114 1.3.4.1,1.3.5.1,1.3.5.4 2.074e-230 731.0
HKD2_k127_2427409_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000007444 182.0
HKD2_k127_2435397_0 Domain related to MnhB subunit of Na+/H+ antiporter K05566 - - 0.0000000000000000000000000000000000000000000005779 171.0
HKD2_k127_2435397_1 TIGRFAM monovalent cation proton antiporter, MnhG PhaG subunit K05571 - - 0.0000000000000000000000000000000003299 136.0
HKD2_k127_2435397_2 Domain of unknown function (DUF4040) - - - 0.000000000000000000000007123 108.0
HKD2_k127_2435397_3 Membrane bound hydrogenase - - - 0.00000000000000000000009907 104.0
HKD2_k127_2435397_4 PFAM multiple resistance and pH regulation protein F K05570 - - 0.0000000003071 61.0
HKD2_k127_2435397_5 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.000000001796 62.0
HKD2_k127_2439717_0 Carbamoyl-phosphate synthase, small chain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006991 484.0
HKD2_k127_2439717_1 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 402.0
HKD2_k127_2439717_2 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006507 295.0
HKD2_k127_2447975_0 - - - - 0.0000000000000000000000000000000000000000000007596 178.0
HKD2_k127_2447975_1 to orf3 of fosmid clone 4B7mr3 - - - 0.00000000000000000000000000000000000000001338 162.0
HKD2_k127_2449403_0 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 305.0
HKD2_k127_2449403_1 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.000000341 55.0
HKD2_k127_2457072_0 Thioredoxin - - - 0.00000000000000000000000000000000000001568 148.0
HKD2_k127_2457072_1 SnoaL-like domain - - - 0.00000000002853 67.0
HKD2_k127_2457072_2 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.000000001455 62.0
HKD2_k127_2460637_0 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000001588 119.0
HKD2_k127_2460637_1 cyclase family K07130 - 3.5.1.9 0.00000000000000000001118 94.0
HKD2_k127_2464608_0 tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008286 429.0
HKD2_k127_2483771_0 PFAM Beta propeller domain K14475 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 556.0
HKD2_k127_2483771_1 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K03733,K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 425.0
HKD2_k127_2483771_2 PFAM Methyltransferase type - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 306.0
HKD2_k127_2483771_3 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.0000000000000000000000000000000000000000000000000000001783 201.0
HKD2_k127_2483771_4 PBS lyase HEAT-like repeat K22221 - - 0.00000000002953 72.0
HKD2_k127_2485570_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 4.132e-262 819.0
HKD2_k127_2485570_1 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000002103 242.0
HKD2_k127_2486336_0 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000000003316 210.0
HKD2_k127_2486336_1 Glutaredoxin - - - 0.000000000000000000000000000001403 122.0
HKD2_k127_2486336_2 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000000001318 75.0
HKD2_k127_2486336_3 - - - - 0.00009655 52.0
HKD2_k127_2503232_0 toxin activity - - - 0.000000000000000000000000000000000000000000003989 175.0
HKD2_k127_2505127_0 TIGRFAM AAA family ATPase, CDC48 subfamily K13525 - - 7.949e-313 967.0
HKD2_k127_2505127_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003647 439.0
HKD2_k127_2505127_2 PFAM Methionine synthase, vitamin-B12 independent K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007292 372.0
HKD2_k127_2505127_3 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.0000000000000000000000000000000000000004171 160.0
HKD2_k127_2521712_0 Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 457.0
HKD2_k127_2521712_1 PFAM metallophosphoesterase K07096 - - 0.000000000000000000000000000000000000000000004017 169.0
HKD2_k127_2521712_2 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000000000000000000001004 150.0
HKD2_k127_2530095_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 5.728e-302 933.0
HKD2_k127_2530095_1 V-type ATPase 116kDa subunit family K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 619.0
HKD2_k127_2530095_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008899 574.0
HKD2_k127_2530095_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005386 400.0
HKD2_k127_2530095_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000000000000004251 118.0
HKD2_k127_2530095_5 ATP synthase subunit C K02124 - - 0.0000000000000000000001918 98.0
HKD2_k127_2530095_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015399,GO:0015405,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022853,GO:0022857,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098660,GO:0099131 - 0.0000009485 55.0
HKD2_k127_2537650_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 442.0
HKD2_k127_2537650_1 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000003236 194.0
HKD2_k127_2556149_0 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005633 447.0
HKD2_k127_2556149_1 Putative small multi-drug export protein - - - 0.000000000000000000000000000000005529 132.0
HKD2_k127_2556149_2 Belongs to the UPF0285 family - - - 0.00000000000000000000000000000002036 143.0
HKD2_k127_2556149_3 phosphoglycerate mutase K15635 - 5.4.2.12 0.00002545 50.0
HKD2_k127_2589314_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006965 423.0
HKD2_k127_2605942_0 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 422.0
HKD2_k127_2605942_1 PFAM cobalamin (vitamin B12) biosynthesis CbiM protein K02007 - - 0.0000000000000000000000000000000000000000000001992 168.0
HKD2_k127_2611218_0 Branched-chain amino acid transport system permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 359.0
HKD2_k127_2611218_1 COG0559 Branched-chain amino acid ABC-type transport system, permease components K01997,K11956 - - 0.00000000000000000000000000000000000000000000000000000000004575 206.0
HKD2_k127_2648714_0 Holliday junction DNA helicase ruvB C-terminus K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009355 456.0
HKD2_k127_2648714_1 Crossover junction endodeoxyribonuclease RuvC K01159 - 3.1.22.4 0.000000000000000000000000000000000000000000000000003066 190.0
HKD2_k127_2648714_2 RuvA, C-terminal domain K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000001933 171.0
HKD2_k127_2648714_3 PhoU domain - - - 0.00000000000000000000000000000000003497 139.0
HKD2_k127_268982_0 to orf2, orf11, orf12, orf13, orf14, orf15 of fosmid clone 4B7mr3 - - - 0.0000000000000000000000000000000000000000000000000000000000000006716 232.0
HKD2_k127_268982_1 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.000001522 51.0
HKD2_k127_2693318_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 469.0
HKD2_k127_2693318_1 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005298 291.0
HKD2_k127_2697551_0 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000000000000000000000000000000000000000000000000000002811 204.0
HKD2_k127_2697551_1 EamA-like transporter family - - - 0.0000000000000000000399 96.0
HKD2_k127_2697551_2 transferase activity, transferring glycosyl groups - - - 0.000255 47.0
HKD2_k127_2698295_0 Rubrerythrin - - - 0.000000000000000000000000000000000000006911 153.0
HKD2_k127_2698295_1 PFAM Linocin_M18 bacteriocin protein - - - 0.000000000000000000000000000000002815 132.0
HKD2_k127_2703855_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 1.76e-205 648.0
HKD2_k127_2703855_1 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 403.0
HKD2_k127_2703855_2 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005612 339.0
HKD2_k127_2703855_3 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000001387 228.0
HKD2_k127_2706280_0 UbiA prenyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000009809 222.0
HKD2_k127_2706280_1 Sodium/hydrogen exchanger family K03455 - - 0.000000000000000000000003884 115.0
HKD2_k127_2706280_2 - - - - 0.00000000001407 75.0
HKD2_k127_2753736_0 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000208 223.0
HKD2_k127_2753736_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.00000000000000000000000000000000000000000000000006474 180.0
HKD2_k127_2753736_2 PFAM AMMECR1 domain protein K09141 - - 0.00000000000000000000000000000000000000000785 159.0
HKD2_k127_2791335_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000584 253.0
HKD2_k127_2791335_1 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000000000006277 186.0
HKD2_k127_2791335_2 homolog of PrgY (pheromone shutdown protein) - - - 0.000000005777 59.0
HKD2_k127_2811610_0 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 419.0
HKD2_k127_2811610_1 PFAM oxidoreductase nitrogenase, component 1 - - - 0.000000000000000000000000000000000000000000001811 169.0
HKD2_k127_2819487_0 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 4.051e-208 662.0
HKD2_k127_2833465_0 Nitrogenase component 1 type Oxidoreductase K02591 - 1.18.6.1 9.315e-232 725.0
HKD2_k127_2833465_1 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 385.0
HKD2_k127_2833465_2 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.00000000000000000000513 92.0
HKD2_k127_2835284_0 Pas domain - - - 0.000000000000000000000000000000004542 141.0
HKD2_k127_289844_0 PFAM AIR synthase related protein K07123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003781 432.0
HKD2_k127_289844_1 methanogen marker protein 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 287.0
HKD2_k127_289844_2 transcription factor (CBF NF-Y) - - - 0.0000000000000000000000000001055 116.0
HKD2_k127_2937843_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004045 251.0
HKD2_k127_2937843_1 Stage II sporulation protein E K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000003874 199.0
HKD2_k127_2937843_2 STAS domain K04749,K06378 - - 0.0000000000000002757 87.0
HKD2_k127_2937935_0 homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 370.0
HKD2_k127_2937935_1 amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000000000000000005506 211.0
HKD2_k127_2937935_2 Hydrogenase maturation protease K03605 - - 0.0000000000000009585 85.0
HKD2_k127_2951097_0 Tetratricopeptide repeat K12600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 336.0
HKD2_k127_2951097_1 PFAM TPR repeat-containing protein - - - 0.00004218 57.0
HKD2_k127_2955150_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 454.0
HKD2_k127_2955150_1 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000000007894 110.0
HKD2_k127_2962368_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 524.0
HKD2_k127_2962368_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007425 481.0
HKD2_k127_2962368_2 serine threonine protein kinase K07178 - 2.7.11.1 0.0000000000000000000000000000000000009439 141.0
HKD2_k127_2968302_0 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008366 397.0
HKD2_k127_2968302_1 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.000000000000000000000000000000000000000000000000000000557 196.0
HKD2_k127_2968302_2 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.00000000000000000000000000000000000000000000001784 184.0
HKD2_k127_2968302_3 - K06868 - 2.5.1.73 0.000000006422 61.0
HKD2_k127_3008258_0 DegT/DnrJ/EryC1/StrS aminotransferase family K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 525.0
HKD2_k127_3008258_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 308.0
HKD2_k127_3008258_2 PFAM PBS lyase HEAT-like repeat - - - 0.0000000000000000000000000029 120.0
HKD2_k127_3008258_3 PFAM PP-loop domain protein - - - 0.0000000000000003906 80.0
HKD2_k127_3013367_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 4.234e-276 854.0
HKD2_k127_3013367_1 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 2.048e-273 844.0
HKD2_k127_30350_0 COG1404 Subtilisin-like serine proteases K14645 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000254 158.0
HKD2_k127_3040447_0 uridine kinase K00855,K00876 - 2.7.1.19,2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005309 300.0
HKD2_k127_3040447_1 Cyclophilin-like K09143 - - 0.0000000000000000000000000000000001543 136.0
HKD2_k127_3040447_2 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.0000000000000000533 83.0
HKD2_k127_3040447_3 PFAM response regulator receiver K11443 - - 0.0000000000000002168 84.0
HKD2_k127_3065342_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 5.977e-291 906.0
HKD2_k127_3065342_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 9.562e-263 822.0
HKD2_k127_306594_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000001882 166.0
HKD2_k127_306594_1 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.0000000000000000000000000000001047 126.0
HKD2_k127_3071382_0 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005616 256.0
HKD2_k127_3071382_1 Catalyzes the dephosphorylation of 2-phosphoglycolate K22223 - 3.1.3.18 0.000000000000000000000000000000000000000000001198 169.0
HKD2_k127_3071382_2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone - - - 0.0000000000000373 82.0
HKD2_k127_3071382_3 PRC-barrel domain - - - 0.00000000000322 69.0
HKD2_k127_3086883_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 571.0
HKD2_k127_3086883_1 Polymer-forming cytoskeletal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 314.0
HKD2_k127_3144127_0 Domain of unknown function (DUF3821) - - - 0.000000000000000000000000000000000000000003552 167.0
HKD2_k127_3167726_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 2.165e-211 664.0
HKD2_k127_3170804_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002035 553.0
HKD2_k127_3170804_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006594 329.0
HKD2_k127_3170804_2 AAA domain K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008979 312.0
HKD2_k127_3170804_3 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000008262 222.0
HKD2_k127_3170804_4 response regulator, receiver - - - 0.000000000000000000000000000000000000000000000000000000001882 207.0
HKD2_k127_3170804_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000002652 89.0
HKD2_k127_3172419_0 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 351.0
HKD2_k127_3172419_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17884 - 2.7.8.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005934 299.0
HKD2_k127_3172419_2 TIGRFAM signal peptide peptidase SppA, 36K type K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009957 278.0
HKD2_k127_3172419_3 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.0000000000000000000000000000000000000000003159 164.0
HKD2_k127_3182400_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008958 284.0
HKD2_k127_3182400_1 DoxX K16937 - 1.8.5.2 0.00000000000005145 80.0
HKD2_k127_319732_0 TIGRFAM NiFe hydrogenase maturation protein HypF K04656 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 578.0
HKD2_k127_3200103_0 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000000000000001397 207.0
HKD2_k127_3200103_1 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.0000000000000000000000000000000000000000000001273 172.0
HKD2_k127_3200103_2 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000000000000000000002144 154.0
HKD2_k127_3200103_3 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.0000000000000000000000000000000009934 131.0
HKD2_k127_3200103_4 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000000000000007357 109.0
HKD2_k127_3200103_5 CRS1_YhbY K07574 - - 0.00000000000000000000001523 103.0
HKD2_k127_3200103_6 structural constituent of ribosome K02924 - - 0.0000000000000000004157 87.0
HKD2_k127_3215977_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003241 600.0
HKD2_k127_3215977_1 methylase K00571 - 2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 351.0
HKD2_k127_3215977_2 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000006537 237.0
HKD2_k127_3215977_3 PFAM Uncharacterised conserved protein UCP037465, zinc finger protein, AF1427 - - - 0.0000000000003568 70.0
HKD2_k127_3222998_0 PFAM ribonuclease II K01147 - 3.1.13.1 0.000000000000000000000000000000000000000002692 160.0
HKD2_k127_3222998_1 Isoprenylcysteine carboxyl methyltransferase - - - 0.000000000000000000000000003894 111.0
HKD2_k127_3222998_2 Psort location Cytoplasmic, score K07138 - - 0.00000000008467 65.0
HKD2_k127_3224768_0 ABC transporter transmembrane region K06147,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 303.0
HKD2_k127_3272979_0 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005085 381.0
HKD2_k127_3272979_1 PFAM ribosomal protein S8E K02995 - - 0.000000000000000000000000000000000000004796 147.0
HKD2_k127_3272979_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.00000000000000001425 84.0
HKD2_k127_3273064_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 550.0
HKD2_k127_3273064_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 339.0
HKD2_k127_3273064_2 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.00000000000000000000000000000000000000000000000000000000000000000000001339 244.0
HKD2_k127_3273064_3 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.0000000000000000000000000000000000000000000000000000000000000000003253 231.0
HKD2_k127_3286853_0 Protein of unknown function DUF58 - - - 0.0000000000000000000000001535 115.0
HKD2_k127_3286853_1 Periplasmic copper-binding protein (NosD) - - - 0.0000002083 62.0
HKD2_k127_32931_0 - - - - 0.00000000000000000000000000000000000000000697 166.0
HKD2_k127_32931_1 COG0433 Predicted ATPase - - - 0.0000000000000000241 83.0
HKD2_k127_3309359_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 363.0
HKD2_k127_3309359_1 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 311.0
HKD2_k127_3309359_2 Belongs to the UPF0218 family K09735 - - 0.000000000000000000000000000000000002137 144.0
HKD2_k127_3309359_3 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.00000000000000000000000001442 111.0
HKD2_k127_3309359_4 Large family of predicted nucleotide-binding domains K07158 - - 0.00000000000000000000000006617 119.0
HKD2_k127_3318642_0 regulatory, ligand-binding protein related to C-terminal domains of K channels K07228 - - 0.0000000000000000000000000000000000000000000000000002224 192.0
HKD2_k127_3318642_1 Sodium hydrogen exchanger K03455 - - 0.000000000000000000000000000000000000000003212 159.0
HKD2_k127_3318642_2 CHASE4 domain - - - 0.0000000000000000000000000000000000000004429 164.0
HKD2_k127_3325504_0 PFAM phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 578.0
HKD2_k127_3325504_1 PHP-associated - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001156 280.0
HKD2_k127_3325504_2 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000000001478 111.0
HKD2_k127_3325504_3 Methyltransferase domain - - - 0.000000291 52.0
HKD2_k127_3325504_4 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0003759 49.0
HKD2_k127_333466_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.567e-280 873.0
HKD2_k127_333466_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000003694 61.0
HKD2_k127_3356487_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005709 424.0
HKD2_k127_3357990_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003257 270.0
HKD2_k127_3357990_1 - - - - 0.00000000000000000000000000000002081 127.0
HKD2_k127_3357990_2 DNA ligase D, 3-phosphoesterase domain - - - 0.0000000000000000000000000997 107.0
HKD2_k127_3431248_0 Tripartite tricarboxylate transporter TctA family K08971 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 467.0
HKD2_k127_3431248_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 364.0
HKD2_k127_3431248_2 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000366 274.0
HKD2_k127_3438955_0 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003356 385.0
HKD2_k127_345813_0 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 523.0
HKD2_k127_345813_1 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000001979 99.0
HKD2_k127_3484489_0 TIGRFAM UbiD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 593.0
HKD2_k127_3484489_1 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 301.0
HKD2_k127_3484489_2 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000001806 231.0
HKD2_k127_3494650_0 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000002904 201.0
HKD2_k127_3494650_1 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000003872 184.0
HKD2_k127_3494650_2 Predicted membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000000007593 178.0
HKD2_k127_3494650_3 chorismate mutase K04093 - 5.4.99.5 0.0000002114 52.0
HKD2_k127_3502097_0 PFAM alanine dehydrogenase PNT domain protein K00259,K00324 GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1,1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006193 590.0
HKD2_k127_3502097_1 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.0000000000000004077 78.0
HKD2_k127_3502097_2 PBS lyase HEAT-like repeat - - - 0.000008911 52.0
HKD2_k127_3527416_0 PFAM Phosphoribosylglycinamide synthetase K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006589 554.0
HKD2_k127_3527416_1 PFAM Radical SAM domain protein K06937 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 533.0
HKD2_k127_3527416_2 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004285 433.0
HKD2_k127_3527416_3 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 419.0
HKD2_k127_3527416_4 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.0000000000000000000000000000000000000000000000000000000000026 214.0
HKD2_k127_3527416_5 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000008073 199.0
HKD2_k127_3527416_6 - - - - 0.000000000000000006789 87.0
HKD2_k127_3543038_0 Sodium Bile acid symporter family K03453 - - 0.000000000000000000000000000001759 133.0
HKD2_k127_3543038_1 - - - - 0.00000000000000000000002819 113.0
HKD2_k127_3559005_0 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 312.0
HKD2_k127_3559005_1 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007611 289.0
HKD2_k127_3577152_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004213 409.0
HKD2_k127_3577152_1 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 320.0
HKD2_k127_3577152_2 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.00001983 49.0
HKD2_k127_359331_0 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.000000000000008051 76.0
HKD2_k127_3607194_0 - - - - 0.000000000000000002799 92.0
HKD2_k127_363119_0 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007167 379.0
HKD2_k127_363119_1 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.00002976 46.0
HKD2_k127_3639413_0 TGS domain protein K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 529.0
HKD2_k127_3639413_1 Pyruvate kinase, alpha/beta domain K09126 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001823 280.0
HKD2_k127_3639413_2 Stage II sporulation protein M - - - 0.000000000000000000000000000000000000000000000000002031 192.0
HKD2_k127_3639413_3 - - - - 0.000000000000000000000000000000000000000000004565 165.0
HKD2_k127_3639413_4 Integral membrane protein DUF92 - - - 0.00000000000001146 74.0
HKD2_k127_3639766_0 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.00000000000000000000000000000000000000000001265 166.0
HKD2_k127_3639766_1 TIGRFAM small GTP-binding protein K06944 - - 0.0000000000000000000000000000000000001706 142.0
HKD2_k127_3640407_0 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001008 279.0
HKD2_k127_3640407_1 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000002472 226.0
HKD2_k127_3640407_2 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000005393 163.0
HKD2_k127_3640407_3 Zinc-ribbon containing domain - - - 0.00000000000000000000000000003777 118.0
HKD2_k127_3640407_4 PFAM Desulfoferrodoxin Dfx domain protein - - - 0.000000000000007679 76.0
HKD2_k127_3657807_0 DEAD DEAH box helicase K06877 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 436.0
HKD2_k127_3657807_1 Exonuclease K07502 - - 0.0000000000000000000000000000000001144 135.0
HKD2_k127_3658208_0 Protein of unknown function (DUF1102) - - - 0.0000000000000000000000000000000000000000000000000001772 207.0
HKD2_k127_3658208_1 Domain of unknown function (DUF296) K06934 - - 0.000000001043 59.0
HKD2_k127_3678818_0 PFAM methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 331.0
HKD2_k127_3685376_0 - - - - 0.00000000000000000000000000000000000000000000000000000003029 211.0
HKD2_k127_3685376_1 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 0.000000000000000000000000000000000000005119 146.0
HKD2_k127_3691585_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 4.826e-194 610.0
HKD2_k127_3691585_1 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008349 278.0
HKD2_k127_3691585_2 transcription activator, effector binding - - - 0.00000000000000000000000000000000000000000000000000000005224 201.0
HKD2_k127_3691585_3 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.000000000000000000000000000000000005328 139.0
HKD2_k127_3692901_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 5.343e-205 647.0
HKD2_k127_3692901_1 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.000000000000000000000000000000000006985 139.0
HKD2_k127_3693124_0 TIGRFAM small GTP-binding protein K06944 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 460.0
HKD2_k127_370993_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 6.46e-310 961.0
HKD2_k127_370993_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 400.0
HKD2_k127_370993_2 Belongs to the PdaD family K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006381 310.0
HKD2_k127_370993_3 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.0000000000000000000187 97.0
HKD2_k127_3725559_0 - - - - 0.0000000000000000006464 92.0
HKD2_k127_3725559_1 - - - - 0.000006089 53.0
HKD2_k127_374814_0 Deoxyribodipyrimidine photo-lyase-related protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008316 430.0
HKD2_k127_374814_1 CHAT domain - - - 0.000000000000007433 81.0
HKD2_k127_3764557_0 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000000000000000000000000000000004547 150.0
HKD2_k127_3764557_1 - - - - 0.000454 52.0
HKD2_k127_3795314_0 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 427.0
HKD2_k127_3795314_1 Lon protease (S16) C-terminal proteolytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003081 245.0
HKD2_k127_3795314_2 EamA-like transporter family - - - 0.0000000004722 64.0
HKD2_k127_3814460_0 PFAM AIR synthase related protein K07388 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 437.0
HKD2_k127_3814611_0 PFAM Uncharacterised protein family UPF0066 - - - 0.000000000000000000000000000000000000000001235 167.0
HKD2_k127_3814611_1 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000001986 124.0
HKD2_k127_3826241_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 590.0
HKD2_k127_3826241_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 497.0
HKD2_k127_3826241_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.00000000000000000000000000000000000000000000000000000000000000000001799 235.0
HKD2_k127_3856049_0 Protein of unknown function (DUF460) K09150 - - 1.535e-231 733.0
HKD2_k127_3856049_1 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000001032 226.0
HKD2_k127_3856049_2 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000001768 133.0
HKD2_k127_3856049_3 Rio2, N-terminal K07179 - 2.7.11.1 0.00000000000000000001169 94.0
HKD2_k127_3856049_4 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360 - 0.00000000000000000001176 94.0
HKD2_k127_3856578_0 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.00000000000000000000000000000000000000000005188 165.0
HKD2_k127_3856578_1 - - - - 0.000000000000000000000000000000002211 137.0
HKD2_k127_3876135_0 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000001881 116.0
HKD2_k127_3876135_1 Cytochrome C biogenesis protein - - - 0.000000000000000000000000003294 127.0
HKD2_k127_3876135_2 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.0000000000009776 70.0
HKD2_k127_3878682_0 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006635 424.0
HKD2_k127_3878682_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004579 421.0
HKD2_k127_3878682_2 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001902 282.0
HKD2_k127_3879811_0 RimK domain protein ATP-grasp - - - 0.000000000000000000000000000000000000000000000000000007493 194.0
HKD2_k127_3879811_1 RimK-like ATPgrasp N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000003434 189.0
HKD2_k127_3884726_0 Ribonuclease R winged-helix domain K09720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007743 439.0
HKD2_k127_3884726_1 TIGRFAM deoxycytidine triphosphate deaminase K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000001588 170.0
HKD2_k127_3892099_0 Pfam:DUF137 K09722 - 6.3.2.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000888 331.0
HKD2_k127_3892099_1 PFAM GHMP kinase K06982 - 2.7.1.169 0.000000000000000000000000000000001371 132.0
HKD2_k127_3896164_0 SMART Elongator protein 3 MiaB NifB K22226 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 389.0
HKD2_k127_3896164_1 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000007417 229.0
HKD2_k127_3905325_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004793 548.0
HKD2_k127_3905325_1 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 336.0
HKD2_k127_3905325_2 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.00000000000000000000000000000000000000000000000004171 181.0
HKD2_k127_3905325_3 SpoVT / AbrB like domain - - - 0.000000000000000000000008866 103.0
HKD2_k127_3945647_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 1.671e-212 677.0
HKD2_k127_3945647_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006113 269.0
HKD2_k127_3945647_2 - - - - 0.0000000000000000000000000000000000002957 146.0
HKD2_k127_3945647_3 PFAM PEGA domain - - - 0.00006789 49.0
HKD2_k127_3946638_0 Fumarate reductase succinate dehydrogenase flavoprotein K00239 - 1.3.5.1,1.3.5.4 2.343e-229 721.0
HKD2_k127_3946638_1 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000002138 230.0
HKD2_k127_3956800_0 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004603 263.0
HKD2_k127_3956800_1 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000001977 234.0
HKD2_k127_3956800_2 NMT1-like family K02051 - - 0.000000000000007626 78.0
HKD2_k127_3959768_0 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.000000000000000000000000000000000000000000000000000000000001408 220.0
HKD2_k127_3959768_1 ATP-binding region, ATPase domain protein domain protein - - - 0.000000000000000000000000000000001719 132.0
HKD2_k127_3963018_0 Mitochondrial small ribosomal subunit Rsm22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002137 295.0
HKD2_k127_3965962_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004887 394.0
HKD2_k127_3965962_1 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000153 96.0
HKD2_k127_3965962_2 COG3634 Alkyl hydroperoxide reductase, large subunit K00384 - 1.8.1.9 0.000000000000000000009116 96.0
HKD2_k127_4002867_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 1.763e-288 894.0
HKD2_k127_4002867_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 7.208e-204 641.0
HKD2_k127_4002867_2 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000003025 238.0
HKD2_k127_4004187_0 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009037 324.0
HKD2_k127_4004187_1 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007328 318.0
HKD2_k127_4004187_2 Prephenate dehydratase K04518 - 4.2.1.51 0.000000000000000000000000000000000000000000000000000001214 204.0
HKD2_k127_4010339_0 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 509.0
HKD2_k127_4010339_1 peptidase M42 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008254 454.0
HKD2_k127_4010339_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 445.0
HKD2_k127_4010339_3 PFAM phosphatidate cytidylyltransferase - - - 0.000000000000000000000000000000000000000006927 160.0
HKD2_k127_4014681_0 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 572.0
HKD2_k127_4014681_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000001871 251.0
HKD2_k127_4014681_2 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000000000002697 199.0
HKD2_k127_4018805_0 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001382 281.0
HKD2_k127_4018805_1 Domain of unknown function (DUF4962) - - - 0.0000000000000000000000000000001174 144.0
HKD2_k127_4018805_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K03406 - - 0.0000000000000000000000000000001841 130.0
HKD2_k127_4024726_0 to orf2, orf11, orf12, orf13, orf14, orf15 of fosmid clone 4B7mr3 - - - 0.00000000000000000000000000000000000000000001979 170.0
HKD2_k127_4026085_0 KEOPS complex Cgi121-like subunit K09119 - - 0.0000000000000000000000000000000000000000002507 163.0
HKD2_k127_4026085_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 0.0000000000000000000002352 100.0
HKD2_k127_4055141_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 478.0
HKD2_k127_4055141_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008123 354.0
HKD2_k127_4065463_0 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.00000000000000000000000000000000000000000000000000000000000002274 221.0
HKD2_k127_4069659_0 PFAM von Willebrand factor type A - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009971 277.0
HKD2_k127_4078177_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 429.0
HKD2_k127_4078177_1 Threonyl-tRNA synthetase K01868 - 6.1.1.3 0.0000000000000000000000000000000000000000001644 161.0
HKD2_k127_4078177_2 Domain of unknown function (DUF1894) - - - 0.0000000000005512 72.0
HKD2_k127_4084288_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 486.0
HKD2_k127_4100634_0 involved in cell wall biogenesis K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 436.0
HKD2_k127_4100634_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 404.0
HKD2_k127_4100634_2 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.00000000000000000000000000000000000000000000000445 179.0
HKD2_k127_4100634_3 - - - - 0.0000000000000000002699 93.0
HKD2_k127_4101333_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00440 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.98.1 4.973e-264 815.0
HKD2_k127_4101333_1 coenzyme F420-reducing hydrogenase, delta subunit K00442 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001834 284.0
HKD2_k127_4101333_2 NADH ubiquinone oxidoreductase 20 kDa subunit K00443 - 1.12.98.1 0.00000000000000017 80.0
HKD2_k127_4110409_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 4.693e-277 865.0
HKD2_k127_4120514_0 Belongs to the RtcB family K14415 - 6.5.1.3 5.536e-216 679.0
HKD2_k127_4120514_1 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008882 327.0
HKD2_k127_4120514_2 Involved in protein export K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 309.0
HKD2_k127_4120514_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000002223 232.0
HKD2_k127_4120514_4 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.0000000000000000000000000000000000000000000000000000007587 198.0
HKD2_k127_4120514_5 PFAM BioY protein K03523 - - 0.0000000000000000000000000000000000000000000000007364 180.0
HKD2_k127_4120514_6 - - - - 0.00000000000000000000000008817 109.0
HKD2_k127_4120514_7 Protein of unknown function (DUF2551) - - - 0.0000000000000000000003111 101.0
HKD2_k127_4120514_8 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000001862 90.0
HKD2_k127_4120514_9 Protein-export membrane protein SecD K03072 - - 0.00000000000001111 83.0
HKD2_k127_4151044_0 PFAM AMP-dependent synthetase and ligase K01908 - 6.2.1.17 1.194e-296 932.0
HKD2_k127_4151044_1 to orf3 of fosmid clone 4B7mr3 - - - 0.00000000000006514 83.0
HKD2_k127_4156442_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 307.0
HKD2_k127_4156442_1 PFAM Methylated-DNA- protein -cysteine S-methyltransferase K00567 - 2.1.1.63 0.00000000000000000000000000000001926 140.0
HKD2_k127_4157584_0 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000593 418.0
HKD2_k127_4157584_1 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005489 281.0
HKD2_k127_4158834_0 PFAM ABC transporter related K02068,K03529,K06166,K16786,K16787 - 2.7.8.37 0.000000000000000000000000000000000000000000000000000000000000004672 227.0
HKD2_k127_4158834_1 PFAM ABC transporter K16786 - - 0.000003686 51.0
HKD2_k127_4211331_0 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007387 267.0
HKD2_k127_4217900_0 TspO/MBR family K05770 - - 0.0000000000000000000000000000000000000000000000001183 182.0
HKD2_k127_4217900_1 Domain of unknown function (DUF1894) - - - 0.000000000000000000000000000000002579 134.0
HKD2_k127_4217900_2 Domain of unknown function (DUF1890) - - - 0.0000000000000000001061 90.0
HKD2_k127_4218179_0 glycosyl transferase, family 39 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 394.0
HKD2_k127_4218179_1 involved in cell wall biogenesis K00721 - 2.4.1.83 0.00000000000000000000000000000000000000003342 159.0
HKD2_k127_4277763_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 6.151e-196 617.0
HKD2_k127_4283214_0 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 448.0
HKD2_k127_4283214_1 N-4 methylation of cytosine K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 354.0
HKD2_k127_4283214_2 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000002113 124.0
HKD2_k127_4291723_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K14126 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000001906 233.0
HKD2_k127_4291723_1 Roadblock LC7 K07131 - - 0.000000000000000000000000000000000000000000000000006375 182.0
HKD2_k127_4318622_0 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 4.246e-196 619.0
HKD2_k127_4318622_1 PFAM NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001422 246.0
HKD2_k127_4318622_2 beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008556 244.0
HKD2_k127_4318622_3 Domain of unknown function DUF123 - - - 0.00000000000000000000000000000000000000001473 158.0
HKD2_k127_4318622_4 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.00000000000000000000000000000000002168 135.0
HKD2_k127_4328289_0 Thioredoxin K03671 - - 0.00000000000000000000000000000000000001406 149.0
HKD2_k127_4328289_1 PFAM transcriptional coactivator pterin dehydratase K01724 - 4.2.1.96 0.0000000000000000000000002734 110.0
HKD2_k127_433137_0 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 383.0
HKD2_k127_433137_1 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000003994 168.0
HKD2_k127_4350019_0 - K09712 - - 0.000000000000000000009099 98.0
HKD2_k127_4350019_1 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.00000000000001654 72.0
HKD2_k127_4350019_2 Domain of unknown function (DUF333) K14475 - - 0.0000000000001823 77.0
HKD2_k127_4350019_3 Domain of unknown function (DUF333) K09712 - - 0.000000000597 64.0
HKD2_k127_4358458_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.895e-206 649.0
HKD2_k127_4358458_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008227 350.0
HKD2_k127_4358458_2 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004287 310.0
HKD2_k127_4358458_3 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 295.0
HKD2_k127_4358458_4 TIGRFAM F420-dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006352 299.0
HKD2_k127_4358458_5 - - - - 0.0000000000000004897 83.0
HKD2_k127_4390487_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 557.0
HKD2_k127_4390487_1 Cysteine-rich small domain K08260 - 3.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002567 370.0
HKD2_k127_4390487_2 protein conserved in archaea K09746 - - 0.0000000000000000000000000000000000000000000000000000000000009824 213.0
HKD2_k127_4390487_3 Domain of unknown function (DUF1858) - - - 0.0000000000000000000000003544 106.0
HKD2_k127_4409453_0 HAD-hyrolase-like K07025 - - 0.00000000000000000000000000000000000000000000000005138 187.0
HKD2_k127_4409453_1 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.000000000005794 68.0
HKD2_k127_441196_0 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000238 256.0
HKD2_k127_441196_1 Threonine dehydratase K01754 - 4.3.1.19 0.000000000000000002284 88.0
HKD2_k127_4415742_0 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002225 255.0
HKD2_k127_4415742_1 COG1131 ABC-type multidrug transport system, ATPase component K01990 - - 0.000000000000000000000000000000000009418 140.0
HKD2_k127_4460107_0 lysozyme activity K07273 - - 0.000000000000031 84.0
HKD2_k127_4471085_0 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001897 425.0
HKD2_k127_4471085_1 PFAM band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005107 338.0
HKD2_k127_4471085_2 COG1881 Phospholipid-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000000008318 196.0
HKD2_k127_4488736_0 PFAM CoA-binding domain protein K01905,K22224 - 6.2.1.13 1.779e-260 819.0
HKD2_k127_4488736_1 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007445 385.0
HKD2_k127_4488736_2 Protein of unknown function, DUF255 K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008503 294.0
HKD2_k127_4488736_3 - - - - 0.00000000000000000000000000007992 125.0
HKD2_k127_4504415_0 Trypsin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 370.0
HKD2_k127_450607_0 Belongs to the glutamate synthase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 391.0
HKD2_k127_450607_1 SPFH Band 7 PHB domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003388 274.0
HKD2_k127_450607_2 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000000000000002732 184.0
HKD2_k127_4506442_0 NAD-dependent epimerase dehydratase K01709,K01710 - 4.2.1.45,4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002086 301.0
HKD2_k127_4506442_1 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000009445 119.0
HKD2_k127_4513019_0 PFAM phosphoesterase, RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009174 278.0
HKD2_k127_4513019_1 ribosomal protein S15 K02956 - - 0.00000000000000000000000000000000000000000000000000000000000007013 221.0
HKD2_k127_4513019_2 response regulator - - - 0.0000000000000000000000000000000000000000000000001433 195.0
HKD2_k127_4526304_0 PFAM Protein kinase domain - - - 0.000000009133 64.0
HKD2_k127_4529881_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 1.904e-249 783.0
HKD2_k127_4529881_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003177 433.0
HKD2_k127_4529881_2 subunit (C K02119 - - 0.0004252 49.0
HKD2_k127_4546666_0 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 5.468e-265 827.0
HKD2_k127_4546666_1 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 345.0
HKD2_k127_4546666_2 Nitrogenase component 1 type Oxidoreductase K02587 - - 0.00000000000000000000000000000000000000000000000000000000000000281 234.0
HKD2_k127_4546666_3 Belongs to the eukaryotic ribosomal protein eS6 family K02991 - - 0.000000000000000000000000000000000000000000000364 175.0
HKD2_k127_4554376_0 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 - - 0.000000000000000000000000000000000000000000000000000000000000000000001694 251.0
HKD2_k127_4563513_0 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001705 252.0
HKD2_k127_4563513_1 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 - 2.3.1.101 0.00000000000000000000000000000000000001931 145.0
HKD2_k127_4576920_0 COG0733 Na -dependent transporters of the SNF family K03308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005382 397.0
HKD2_k127_4666984_0 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 532.0
HKD2_k127_4666984_1 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007018 364.0
HKD2_k127_4666984_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004983 348.0
HKD2_k127_4666984_3 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.0000000000007559 69.0
HKD2_k127_467866_0 DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 352.0
HKD2_k127_467866_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01563 - 3.8.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 343.0
HKD2_k127_467866_2 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000005363 204.0
HKD2_k127_467866_3 DNA polymerase beta - - - 0.000000000000000000000000000000000000001428 155.0
HKD2_k127_467866_4 - - - - 0.00000000000000006616 87.0
HKD2_k127_467866_5 HEPN domain K09132 - - 0.0008386 48.0
HKD2_k127_4689766_0 PFAM PfkB domain protein - - - 0.000000000000000000000000000000000000000000000000000001473 202.0
HKD2_k127_4691583_0 Protein of unknown function (DUF354) K09726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 323.0
HKD2_k127_4691583_1 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000001576 184.0
HKD2_k127_4691583_2 PFAM LmbE family protein - - - 0.000000000009521 66.0
HKD2_k127_4691583_3 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000009534 65.0
HKD2_k127_4695602_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1524.0
HKD2_k127_4704200_0 TIGRFAM cell division ATPase MinD K03609 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 377.0
HKD2_k127_4704200_1 - - - - 0.00000000000000000000000000000000000000000000882 169.0
HKD2_k127_4704200_2 PFAM Roadblock LC7 family protein - - - 0.0000000000000000000000000000000001691 145.0
HKD2_k127_4704200_3 - - - - 0.0000002886 62.0
HKD2_k127_4714864_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 - 4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 326.0
HKD2_k127_4714864_1 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 285.0
HKD2_k127_4714864_2 resolvase K14060 - - 0.00000000000000000000000005274 114.0
HKD2_k127_4714864_3 resolvase K14060 - - 0.000003899 48.0
HKD2_k127_4715144_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 5.763e-215 671.0
HKD2_k127_4715144_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000003598 238.0
HKD2_k127_4715144_2 phosphohydrolase (DHH superfamily) K07097 - - 0.000000000000000003948 85.0
HKD2_k127_4723665_0 - - - - 0.0000000000001392 78.0
HKD2_k127_4723665_1 Protein of unknown function (DUF998) - - - 0.000001108 58.0
HKD2_k127_4727200_0 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000000000000000000000000000000000000001387 257.0
HKD2_k127_4727200_1 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000006464 230.0
HKD2_k127_4729272_0 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 369.0
HKD2_k127_4729272_1 membrane K09167 - - 0.000000000000000000000000000000000000000000000000000002035 197.0
HKD2_k127_4737073_0 PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain K10947 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 532.0
HKD2_k127_4737073_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003973 248.0
HKD2_k127_4748733_0 cation diffusion facilitator family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 484.0
HKD2_k127_4748733_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 356.0
HKD2_k127_4748733_2 TIGRFAM intracellular protease, PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000001076 175.0
HKD2_k127_4748733_3 PFAM thioesterase superfamily - - - 0.000000000000000000000000000000000000000000002251 169.0
HKD2_k127_4748733_4 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.00000000000000000000007456 97.0
HKD2_k127_4748733_5 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.0000000004683 62.0
HKD2_k127_4755689_0 Located on the platform of the 30S subunit K02948 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006424 243.0
HKD2_k127_4755689_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000644 232.0
HKD2_k127_4755689_2 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000004435 75.0
HKD2_k127_4802876_0 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002064 274.0
HKD2_k127_4802876_1 - - - - 0.000000000001156 71.0
HKD2_k127_480426_0 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009218 371.0
HKD2_k127_4846958_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000177 245.0
HKD2_k127_4846958_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000832 211.0
HKD2_k127_4857283_0 - - - - 0.00000000000000000000000000000000000000000006925 168.0
HKD2_k127_4857283_1 PFAM cyclase family protein K07130 - 3.5.1.9 0.0000000000000000000000001585 107.0
HKD2_k127_4857283_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K03431 - 5.4.2.10 0.000000000000002134 87.0
HKD2_k127_4875634_0 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.000000000000000000000000000000000000000000001062 173.0
HKD2_k127_4875634_1 repeat-containing protein - - - 0.00000007545 65.0
HKD2_k127_4891458_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 3.297e-228 710.0
HKD2_k127_4891458_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002134 245.0
HKD2_k127_4900950_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.14e-199 633.0
HKD2_k127_4900950_1 PFAM asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000003486 229.0
HKD2_k127_4900950_2 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000003311 95.0
HKD2_k127_4900950_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.00002216 53.0
HKD2_k127_4928424_0 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 542.0
HKD2_k127_4928424_1 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002271 326.0
HKD2_k127_4928424_2 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.0000000000000000000000000000000000000000000000000001003 191.0
HKD2_k127_4943915_0 Belongs to the HpcH HpaI aldolase family K01630 - 4.1.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000009904 264.0
HKD2_k127_4943915_1 glycolate biosynthetic process K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000458 168.0
HKD2_k127_4943915_2 Methionine biosynthesis protein MetW - - - 0.0000000000002477 78.0
HKD2_k127_4943915_3 D-glycero-D-manno-heptose 7-phosphate metabolic process K03271 - 5.3.1.28 0.000000000208 63.0
HKD2_k127_4953796_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009833 550.0
HKD2_k127_4953796_1 PFAM ABC transporter related K09695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 411.0
HKD2_k127_4953796_2 PFAM ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003282 334.0
HKD2_k127_4977299_0 Involved in cell shape control K22222 - - 3.075e-209 657.0
HKD2_k127_4977299_1 PFAM amine oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 516.0
HKD2_k127_4977299_2 PFAM Glycosyl transferase family 2 K07027 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 357.0
HKD2_k127_4977299_3 - - - - 0.0000000000000000000000000000000000000000000000003658 189.0
HKD2_k127_4977299_4 COG0463 Glycosyltransferases involved in cell wall biogenesis K07027 - - 0.0000000000000000000000000000000000005715 152.0
HKD2_k127_4980626_0 Predicted membrane protein (DUF2070) K08979 - - 0.000000000000000000000000000000000000000000000000000006149 195.0
HKD2_k127_498691_0 PFAM Thiolase K00626 - 2.3.1.9 2.18e-206 649.0
HKD2_k127_498691_1 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000000000000000000000000000000005462 203.0
HKD2_k127_498691_2 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.000000000000006068 75.0
HKD2_k127_498691_3 domain, Protein - - - 0.00000348 53.0
HKD2_k127_5005849_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 400.0
HKD2_k127_5005849_1 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002635 270.0
HKD2_k127_5005849_2 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000002002 160.0
HKD2_k127_5014730_0 binds to the 23S rRNA K02921 - - 0.0000000000000000000000000000000001876 134.0
HKD2_k127_5014730_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000000000000002354 89.0
HKD2_k127_5014730_2 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000007195 81.0
HKD2_k127_5014730_3 Probably involved in the biogenesis of the ribosome K14561 - - 0.00000000000008796 77.0
HKD2_k127_5034690_0 RNA methylase K07446 - 2.1.1.213 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 362.0
HKD2_k127_5048770_0 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006428 466.0
HKD2_k127_5048770_1 Belongs to the MCM family K10726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 398.0
HKD2_k127_5048770_2 protein conserved in archaea K09746 - - 0.0000000000000000000000000000003331 143.0
HKD2_k127_5048770_3 PFAM metallophosphoesterase K06953 - - 0.00000000000001423 75.0
HKD2_k127_5059668_0 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 1.764e-273 856.0
HKD2_k127_5089373_0 Uncharacterized protein conserved in archaea (DUF2117) - - - 0.0000000000000000000000003298 109.0
HKD2_k127_5089373_1 - - - - 0.000000000000000000000008135 111.0
HKD2_k127_5093292_0 PFAM NAD(P) transhydrogenase, beta subunit K00325 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007357 557.0
HKD2_k127_5093292_1 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007879 271.0
HKD2_k127_5129715_0 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 6.579e-262 822.0
HKD2_k127_5152627_0 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009059 404.0
HKD2_k127_5152627_1 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000002577 150.0
HKD2_k127_5199435_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005357 573.0
HKD2_k127_5199435_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007248 497.0
HKD2_k127_5199435_2 Transcription elongation factor Spt5 K02601 - - 0.00000000000000000000000007357 109.0
HKD2_k127_5199435_3 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000002814 88.0
HKD2_k127_5202096_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 445.0
HKD2_k127_5202096_1 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000001179 172.0
HKD2_k127_5202096_2 - - - - 0.00000000000000000000000000004841 118.0
HKD2_k127_5202096_3 Ammonium Transporter K03320 - - 0.0000000001998 61.0
HKD2_k127_5237916_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 576.0
HKD2_k127_5237916_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008758 385.0
HKD2_k127_5237916_2 PFAM Ferritin, Dps family protein K02217 - 1.16.3.2 0.000000000000000000000005988 102.0
HKD2_k127_5261838_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000864 440.0
HKD2_k127_5261838_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0000000000000000000000000000000000000000000000000004816 188.0
HKD2_k127_5312153_0 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006724 290.0
HKD2_k127_5312153_1 Cysteine-rich small domain K08260 - 3.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000001478 267.0
HKD2_k127_5312153_2 Domain of unknown function (DUF1858) - - - 0.00000000000000000000002859 100.0
HKD2_k127_5329283_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 412.0
HKD2_k127_5329283_1 GYD domain - - - 0.0000000000000000004419 91.0
HKD2_k127_5329283_2 Fe-S-cluster oxidoreductase - - - 0.0000000000000001803 85.0
HKD2_k127_5343287_0 amino acid K03294 - - 0.0000000000000000000000002481 111.0
HKD2_k127_5382633_0 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000001815 164.0
HKD2_k127_5382633_1 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.00000000000000000000000000000000000000000002078 162.0
HKD2_k127_5382633_2 - - - - 0.0000000000000000000000000000007812 123.0
HKD2_k127_5412982_0 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000002521 239.0
HKD2_k127_5412982_1 PFAM Uncharacterised protein family (UPF0153) - - - 0.00000000000000000000000000000000000000000000000000008182 191.0
HKD2_k127_5412982_2 ATPases associated with a variety of cellular activities K02006 - - 0.00000000000000000000002867 102.0
HKD2_k127_5423029_0 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003529 397.0
HKD2_k127_5423029_1 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000000000000000000001956 224.0
HKD2_k127_5434982_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 8.17e-232 729.0
HKD2_k127_5434982_1 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000006545 247.0
HKD2_k127_5434982_2 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000000000000000000004625 192.0
HKD2_k127_5434982_3 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.000000000000000000000000000004225 121.0
HKD2_k127_5434982_4 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.0000000000000001391 80.0
HKD2_k127_5492912_0 PFAM Histone deacetylase - - - 0.000000000000000000000000000000000000000000000000004973 185.0
HKD2_k127_5492912_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000005688 183.0
HKD2_k127_5492912_2 PFAM Ribonuclease III K03685 - 3.1.26.3 0.00000000000000000000002089 102.0
HKD2_k127_5505820_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.0 1557.0
HKD2_k127_5505820_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 463.0
HKD2_k127_5505820_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006193 314.0
HKD2_k127_5507736_0 Polysaccharide biosynthesis protein K01709 - 4.2.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004731 354.0
HKD2_k127_5507736_1 3-beta hydroxysteroid dehydrogenase/isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000908 311.0
HKD2_k127_5507736_2 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.000000000000000000000000000000000000000000000000000000000000000000009067 239.0
HKD2_k127_5507736_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000001855 238.0
HKD2_k127_5507736_4 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000001824 203.0
HKD2_k127_5507736_5 COG1202 Superfamily II helicase, archaea-specific - - - 0.0000000000000000000000000000000000000000000000000003362 188.0
HKD2_k127_5507736_6 Glucose-1-phosphate cytidylyltransferase K00978 - 2.7.7.33 0.000000000000000000000000000000000000000000003174 171.0
HKD2_k127_5507736_7 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000001196 137.0
HKD2_k127_5507736_8 - - - - 0.000000000000000000000000000001499 128.0
HKD2_k127_5508515_0 COG0438 Glycosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002115 379.0
HKD2_k127_5508515_1 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 321.0
HKD2_k127_5508515_2 PFAM amine oxidase - - - 0.00000000000000000000000000000002552 128.0
HKD2_k127_5508515_3 PFAM thioesterase superfamily K02614 - - 0.0000000000000000000000001316 110.0
HKD2_k127_5508515_4 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.00002848 47.0
HKD2_k127_5519591_0 TIGRFAM PAS sensor protein - - - 0.0000000000000000000000000000000000000000000000009899 189.0
HKD2_k127_5565685_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 3.593e-196 623.0
HKD2_k127_5565685_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 370.0
HKD2_k127_5565685_2 Domain of unknown function (DUF4445) - - - 0.00000000000000000000000000000000000006198 153.0
HKD2_k127_5567330_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004701 321.0
HKD2_k127_5567330_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000001925 143.0
HKD2_k127_5574742_0 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007229 378.0
HKD2_k127_5574742_1 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005771 287.0
HKD2_k127_5574742_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000002373 175.0
HKD2_k127_5574742_3 TIR domain - - - 0.000000003675 61.0
HKD2_k127_5596844_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 7.668e-214 673.0
HKD2_k127_5596844_1 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 524.0
HKD2_k127_5596844_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008454 359.0
HKD2_k127_5596844_3 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 315.0
HKD2_k127_5596844_4 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 292.0
HKD2_k127_5596844_5 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.000000000000000000000000000000000000000000000000000000000000000000001791 244.0
HKD2_k127_5596844_6 PFAM methyltransferase small K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000000000000000003468 209.0
HKD2_k127_5596844_7 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000000000000000000009226 166.0
HKD2_k127_5596844_8 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000000000000000000000000000000000004888 154.0
HKD2_k127_562275_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1354.0
HKD2_k127_562275_1 PFAM PilT protein domain protein K06865 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003787 262.0
HKD2_k127_5634591_0 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 379.0
HKD2_k127_5634591_1 - - - - 0.000000000000000000302 94.0
HKD2_k127_5634591_2 - - - - 0.000000000000000008812 89.0
HKD2_k127_5641453_0 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005156 288.0
HKD2_k127_5641453_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.0000000000000000000000000000000000000000000000000000000000000000004324 230.0
HKD2_k127_5669348_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 421.0
HKD2_k127_5669348_1 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001086 270.0
HKD2_k127_5679704_0 Uncharacterized membrane protein (DUF2298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 302.0
HKD2_k127_5688592_0 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.000000000000000000000000000000000000000000000005739 183.0
HKD2_k127_5688592_1 B-block binding subunit of TFIIIC - - - 0.000000000000000000000000000000000000000000002162 166.0
HKD2_k127_5688592_2 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000000000001306 129.0
HKD2_k127_5688592_3 - - - - 0.00000000000001511 83.0
HKD2_k127_5693728_0 PFAM HhH-GPD family protein K07457 - - 0.000000000000000000000000000000000000000000000000000000000005926 216.0
HKD2_k127_5693728_1 PFAM class II aldolase adducin family protein K01628 - 4.1.2.17 0.000000000000000000000000000000000000000018 168.0
HKD2_k127_5712686_0 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001632 268.0
HKD2_k127_5712690_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 9.879e-209 659.0
HKD2_k127_5712690_1 transferase hexapeptide repeat containing protein K00973 - 2.7.7.24 0.00000000000000000000000000000007943 126.0
HKD2_k127_5726048_0 CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006002 385.0
HKD2_k127_5726048_1 PFAM formyl transferase domain protein K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000343 261.0
HKD2_k127_5756343_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009988 312.0
HKD2_k127_576829_0 protein conserved in archaea - - - 0.000000000000000000002217 98.0
HKD2_k127_576829_1 Copper binding proteins, plastocyanin/azurin family - - - 0.00000000000000000001379 98.0
HKD2_k127_576829_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000002955 69.0
HKD2_k127_5780072_0 protein kinase activity - - - 0.0000000000000000000000000000000001489 143.0
HKD2_k127_5780072_1 chitinase K01183 - 3.2.1.14 0.00000000000003864 85.0
HKD2_k127_5780864_0 Elongator protein 3, MiaB family, Radical SAM K06935 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 365.0
HKD2_k127_5780864_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000003018 173.0
HKD2_k127_5789738_0 PFAM PilT protein domain protein K06865 - - 2.667e-197 625.0
HKD2_k127_5792625_0 PFAM Peptidase C1A, papain C-terminal - - - 0.0000000000000000000000000000000000000000000000000000000005382 216.0
HKD2_k127_5805269_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 550.0
HKD2_k127_5805269_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 385.0
HKD2_k127_5805269_2 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 299.0
HKD2_k127_5805269_3 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002036 269.0
HKD2_k127_5805269_4 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000001173 242.0
HKD2_k127_5805269_5 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000006241 246.0
HKD2_k127_5805269_6 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000516 220.0
HKD2_k127_5824220_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 367.0
HKD2_k127_5824220_1 bis(5'-adenosyl)-triphosphatase activity K02503,K19710 - 2.7.7.53 0.000000000000000000000000000000002235 135.0
HKD2_k127_5831850_0 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein K18210 - 1.3.4.1 1.81e-210 661.0
HKD2_k127_5831850_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384,K03387 - 1.8.1.9 0.00000000000000000000000000000000000000000004699 164.0
HKD2_k127_5842652_0 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000005909 172.0
HKD2_k127_5869829_0 glyoxalase III activity - - - 0.00000000000000000000000000000000000000000000558 172.0
HKD2_k127_5869829_1 ubiquitin protein ligase activity K16276 GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009057,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010498,GO:0016567,GO:0016740,GO:0019538,GO:0019725,GO:0019787,GO:0019941,GO:0030003,GO:0030163,GO:0031667,GO:0031668,GO:0031669,GO:0032446,GO:0032501,GO:0033554,GO:0036211,GO:0042592,GO:0042594,GO:0043161,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048871,GO:0048878,GO:0050801,GO:0050896,GO:0051603,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0060586,GO:0061630,GO:0061659,GO:0065007,GO:0065008,GO:0070647,GO:0071496,GO:0071704,GO:0098771,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0000000000000003369 87.0
HKD2_k127_5869829_2 - - - - 0.0000000003321 64.0
HKD2_k127_587148_0 protein conserved in bacteria (DUF2179) - - - 0.0000000000000000000000000000000000000000000000000000000000003758 226.0
HKD2_k127_587148_1 PFAM peptidase zinc-dependent K06974 - - 0.00000000000000000000000000000000000000000000000001084 186.0
HKD2_k127_587148_2 Belongs to the UPF0146 family K09713 - - 0.0000000000000000000000000000000000000000000003464 175.0
HKD2_k127_5881162_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004099 450.0
HKD2_k127_589226_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0 1218.0
HKD2_k127_589226_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000064 273.0
HKD2_k127_589226_2 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007679 261.0
HKD2_k127_589226_3 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000006929 257.0
HKD2_k127_589226_4 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.00000000000000000000000000000000000000000000005735 175.0
HKD2_k127_589226_5 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000005135 164.0
HKD2_k127_5895780_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0 1065.0
HKD2_k127_5895780_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005155 282.0
HKD2_k127_5895780_2 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000002289 192.0
HKD2_k127_5895780_3 PFAM Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000007202 135.0
HKD2_k127_5895780_4 - - - - 0.000000000000000000000000007401 117.0
HKD2_k127_5895780_5 cationic amino acid transporter K13866,K13871 - - 0.0000000000000184 76.0
HKD2_k127_5912146_0 - - - - 0.00000000000000000000000000000000000000000000000000431 190.0
HKD2_k127_5912146_1 iron dependent repressor K03709 - - 0.0000001206 56.0
HKD2_k127_5917513_0 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005191 428.0
HKD2_k127_5937462_0 neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002704 363.0
HKD2_k127_5937462_1 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000005536 238.0
HKD2_k127_5937462_2 COG1940 Transcriptional regulator sugar kinase K00845 - 2.7.1.2 0.00000000000000000001205 95.0
HKD2_k127_5937462_3 PFAM CBS domain - - - 0.00000000000000002405 88.0
HKD2_k127_5956242_0 8-oxoguanine DNA glycosylase domain protein K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 294.0
HKD2_k127_5956242_1 - - - - 0.00000000000000000000000000000000000000001263 168.0
HKD2_k127_5966847_0 inorganic K15986 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.6.1.1 3.079e-197 628.0
HKD2_k127_5966847_1 Uncharacterised conserved protein (DUF2156) K01163 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 353.0
HKD2_k127_5966847_2 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007201 330.0
HKD2_k127_5966847_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000002676 174.0
HKD2_k127_5966847_4 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007,K02009 GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000005534 121.0
HKD2_k127_5966847_5 Belongs to the peptidase S8 family - - - 0.000000000009319 66.0
HKD2_k127_5979183_0 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 5.608e-235 739.0
HKD2_k127_5979183_1 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002671 261.0
HKD2_k127_5979183_2 - - - - 0.000000000002079 72.0
HKD2_k127_5983756_0 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005879 266.0
HKD2_k127_5983756_1 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000007236 227.0
HKD2_k127_5983756_2 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 - - 0.0000000000000000000000000000000000000000000000000001657 187.0
HKD2_k127_5983756_3 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.000000000000000000000000000000008221 127.0
HKD2_k127_5983756_4 Binds to the 23S rRNA K02896 - - 0.000000000000000000000000002746 115.0
HKD2_k127_5983756_5 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000001619 104.0
HKD2_k127_5987718_0 Conserved repeat domain - - - 0.000000002438 68.0
HKD2_k127_5993625_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000002056 72.0
HKD2_k127_5993625_1 PBS lyase HEAT-like repeat - - - 0.00009527 48.0
HKD2_k127_6005776_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004863 383.0
HKD2_k127_6005776_1 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 345.0
HKD2_k127_6016204_0 PFAM von Willebrand factor type A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 449.0
HKD2_k127_6020252_0 Domain of unknown function (DUF1917) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004635 299.0
HKD2_k127_6020252_1 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.0000000000000000000000000000000000000000000001431 169.0
HKD2_k127_6026214_0 - - - - 0.00000000000000000000000000000000000000000000000000001082 198.0
HKD2_k127_6030975_0 Binds the lower part of the 30S subunit head K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001035 245.0
HKD2_k127_6030975_1 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000000000000000000000000001938 186.0
HKD2_k127_6030975_2 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000000000000006598 89.0
HKD2_k127_6030975_3 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 GO:0000172,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005732,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.00000000000000002305 89.0
HKD2_k127_6034132_0 COG2133 Glucose sorbosone dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006441 538.0
HKD2_k127_6034132_1 COG2133 Glucose sorbosone dehydrogenases - - - 0.00000000000000000000000000000000006432 141.0
HKD2_k127_6074927_0 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 456.0
HKD2_k127_6074927_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 325.0
HKD2_k127_6074927_2 Phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000005376 163.0
HKD2_k127_6074927_3 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000000000000000000000000004788 156.0
HKD2_k127_6074927_4 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000185 95.0
HKD2_k127_6105685_0 toxin activity - - - 0.0000000000000000000000000000000000000000000000000000000009195 218.0
HKD2_k127_6123796_0 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005395 417.0
HKD2_k127_6123796_1 VIT family - - - 0.0000000004214 60.0
HKD2_k127_6135640_0 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00579 - 2.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000007983 259.0
HKD2_k127_6135640_1 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00578 - 2.1.1.86 0.000000000000000000000000000000000005158 141.0
HKD2_k127_6135640_2 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.000000000000006096 74.0
HKD2_k127_6169272_0 UPF0056 membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000000001963 201.0
HKD2_k127_6169272_1 Peptidase family M23 - - - 0.00000000000000000000000000000000000001302 151.0
HKD2_k127_6169272_2 - - - - 0.0000000000005601 75.0
HKD2_k127_6173573_0 extracellular matrix structural constituent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 461.0
HKD2_k127_6173573_1 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000004055 95.0
HKD2_k127_6185157_0 PFAM amino acid permease-associated region K03294 - - 5.13e-199 629.0
HKD2_k127_6235836_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 292.0
HKD2_k127_6235836_1 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000001576 183.0
HKD2_k127_6276011_0 - - - - 0.00000000000000000000003926 101.0
HKD2_k127_6276011_1 SigmaK-factor processing regulatory protein BofA K06317 - - 0.000000000000000005086 87.0
HKD2_k127_6276011_2 - - - - 0.000000000000000007451 85.0
HKD2_k127_6285469_0 PFAM Isochorismatase - - - 0.0000000000002328 72.0
HKD2_k127_6293971_0 phosphoglycerate mutase K15635 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 509.0
HKD2_k127_6312469_0 Lon protease (S16) C-terminal proteolytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007318 282.0
HKD2_k127_6314211_0 PFAM Orn Lys Arg decarboxylase major region K01582,K01584 - 4.1.1.18,4.1.1.19 0.0 1017.0
HKD2_k127_6327620_0 PFAM conserved K07027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 386.0
HKD2_k127_6327653_0 Uncharacterized protein conserved in archaea (DUF2193) - - - 1.197e-199 627.0
HKD2_k127_6346172_0 - K03561,K12287 - - 0.000000000000000000000000000000000000000000004486 180.0
HKD2_k127_6348273_0 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 603.0
HKD2_k127_6348273_1 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005274 342.0
HKD2_k127_6348273_2 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000001019 207.0
HKD2_k127_6362047_0 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 341.0
HKD2_k127_6362047_1 Domain of unknown function (DUF4962) - - - 0.00000000000000000000000000006072 135.0
HKD2_k127_6362047_2 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000006165 115.0
HKD2_k127_6362047_3 - - - - 0.0000000000000001243 89.0
HKD2_k127_6362047_4 Domain present in carbohydrate binding proteins and sugar hydrolses K07218 - - 0.00000000000000048 93.0
HKD2_k127_6363862_0 Helix-hairpin-helix domain K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 552.0
HKD2_k127_6363862_1 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009993 323.0
HKD2_k127_6363862_2 Winged helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000855 320.0
HKD2_k127_6363862_3 Protein of unknown function (DUF357) K09728 - - 0.00001996 56.0
HKD2_k127_6481798_0 - - - - 0.00000000000000000000000000000000000000000000001359 182.0
HKD2_k127_6487529_0 Belongs to the UPF0284 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 411.0
HKD2_k127_6487529_1 PFAM Phosphatidylglycerophosphatase A - - - 0.0000000000000000000000000000000000000000000000000008692 195.0
HKD2_k127_6487529_2 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.0000000000000000000000000000000000000000000004276 175.0
HKD2_k127_6540078_0 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000654 248.0
HKD2_k127_6540078_1 Protein of unknown function (DUF1614) - - - 0.00000000000000000000000000000000000000000000000000000000000000000007656 238.0
HKD2_k127_6540078_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000000000008294 65.0
HKD2_k127_6540078_3 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.00000000008849 63.0
HKD2_k127_6540790_0 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 546.0
HKD2_k127_6540790_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.0000000000000003219 81.0
HKD2_k127_6582092_0 Di-haem cytochrome c peroxidase - - - 0.000000000000000000000000000000000006218 141.0
HKD2_k127_6582092_1 Peptidase dimerisation domain - - - 0.000000000000000000000000000009496 120.0
HKD2_k127_6582092_2 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000002269 98.0
HKD2_k127_6628102_0 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.0000000000000000000000000000000000000000000002278 174.0
HKD2_k127_6628102_1 membrane-bound metal-dependent hydrolase - - - 0.0000000000000000000000003119 114.0
HKD2_k127_6636848_0 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000001776 233.0
HKD2_k127_6636848_1 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.000000000000000000000000000000003884 136.0
HKD2_k127_6636848_2 - - - - 0.000000003287 64.0
HKD2_k127_6681186_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008984 546.0
HKD2_k127_6681186_1 Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase K00192 - 1.2.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 414.0
HKD2_k127_6681186_2 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha- epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear K00195 - - 0.00000000000000000000000000000000000000000000000000001515 194.0
HKD2_k127_6714188_0 PFAM peptidase M24 K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 432.0
HKD2_k127_6714188_1 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 394.0
HKD2_k127_6714188_2 PFAM AAA ATPase central domain protein - - - 0.000000000000000000000000000000000000001128 153.0
HKD2_k127_6741198_0 Saccharopine dehydrogenase C-terminal domain K00808 - 2.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005317 587.0
HKD2_k127_6741198_1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01581 - 4.1.1.17 0.000000000000000000000000000000000000000000000000000000000000005471 219.0
HKD2_k127_6759251_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002006 256.0
HKD2_k127_6770334_0 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001877 282.0
HKD2_k127_6770334_1 PFAM TrkA-N domain K03499 - - 0.00000000000000000000000000000000000001811 145.0
HKD2_k127_6770334_2 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.000000000000000000000000000000000002208 143.0
HKD2_k127_6771081_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 506.0
HKD2_k127_6771081_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 451.0
HKD2_k127_6771081_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a - - - 0.0000000000000000000000000000000000000000009233 160.0
HKD2_k127_6771081_3 Oxidoreductase K00177 - 1.2.7.3 0.0000000000000007035 78.0
HKD2_k127_6806126_0 Predicted membrane protein (DUF2070) K08979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 306.0
HKD2_k127_6807831_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000003185 235.0
HKD2_k127_6807831_1 4Fe-4S ferredoxin, iron-sulfur binding - - - 0.0000000000000000000000000000000000000000000000000009453 192.0
HKD2_k127_6807831_2 Protein of unknown function (DUF1622) - - - 0.000000000000000000386 92.0
HKD2_k127_6807831_3 Conserved region in glutamate synthase - - - 0.0000000000000001911 79.0
HKD2_k127_6823192_0 PFAM AAA ATPase central domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003222 530.0
HKD2_k127_6823192_1 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 324.0
HKD2_k127_6823192_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.0000000000000000000000000000000002347 134.0
HKD2_k127_689674_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 4.369e-208 653.0
HKD2_k127_689674_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000994 231.0
HKD2_k127_689674_2 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000525 217.0
HKD2_k127_689674_3 PFAM beta-lactamase domain protein - - - 0.000408 43.0
HKD2_k127_6923769_0 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003372 356.0
HKD2_k127_6923769_1 Domain of unknown function (DUF1743) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 314.0
HKD2_k127_6962857_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 563.0
HKD2_k127_6967378_0 Belongs to the HMG-CoA reductase family K00021 - 1.1.1.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 569.0
HKD2_k127_6967378_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 451.0
HKD2_k127_6967378_2 Uncharacterised conserved protein UCP033563 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 419.0
HKD2_k127_6967378_3 Methyltransferase K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000009335 237.0
HKD2_k127_6967378_4 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000007763 169.0
HKD2_k127_6967378_5 - - - - 0.000000002364 64.0
HKD2_k127_698172_0 PFAM peptidase - - - 0.0000000002181 63.0
HKD2_k127_7020433_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003031 430.0
HKD2_k127_7061386_0 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000006494 188.0
HKD2_k127_7061386_1 PFAM TPR repeat-containing protein - - - 0.0001999 50.0
HKD2_k127_7086238_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 5.345e-255 799.0
HKD2_k127_7104364_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 2.643e-196 614.0
HKD2_k127_7104364_1 TIGRFAM hydrogenase accessory protein HypB K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 357.0
HKD2_k127_7104364_2 SMART phosphoesterase PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002061 283.0
HKD2_k127_7104364_3 PFAM ribosomal protein S8E K02995 - - 0.00000000000000000000000000000000000000000000005185 172.0
HKD2_k127_7104364_4 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.0000000000000000000000000000000000000002896 156.0
HKD2_k127_7104364_5 - - - - 0.000000000000000000000000000000000008151 145.0
HKD2_k127_7104364_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 - - 0.000000000000000000000000003765 116.0
HKD2_k127_7104364_7 RNA-binding protein involved in rRNA processing K07569 - - 0.00000000000000004771 82.0
HKD2_k127_7104364_8 - - - - 0.0000007239 61.0
HKD2_k127_7112114_0 PFAM DEAD_2 domain protein K10844 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 420.0
HKD2_k127_7140219_0 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000649 251.0
HKD2_k127_7140219_1 NMT1-like family K02051 - - 0.000000000000004601 81.0
HKD2_k127_7147434_0 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004722 276.0
HKD2_k127_7195206_0 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 561.0
HKD2_k127_7195206_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000003624 79.0
HKD2_k127_7249527_0 Belongs to the glutamate synthase family - - - 8.679e-276 853.0
HKD2_k127_7249527_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 7.565e-205 645.0
HKD2_k127_7249527_2 PFAM glutamine amidotransferase, class-II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005144 556.0
HKD2_k127_7249527_3 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 515.0
HKD2_k127_7249527_4 Coenzyme F420 hydrogenase dehydrogenase, beta subunit K00441 - 1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004344 402.0
HKD2_k127_7249527_5 PFAM glutamate synthase alpha subunit domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 349.0
HKD2_k127_7256859_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 387.0
HKD2_k127_7256859_1 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.00000000000000000000000000001736 119.0
HKD2_k127_7281113_0 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000009046 195.0
HKD2_k127_7281113_1 Esterase of the alpha-beta hydrolase superfamily K07001 GO:0003674,GO:0003824,GO:0016787 - 0.00002705 47.0
HKD2_k127_7287588_0 Phosphate transport regulator K07220 - - 0.000000000000000000000000000000000000000000000000005391 190.0
HKD2_k127_7287588_1 - - - - 0.00000000000001301 81.0
HKD2_k127_7287588_2 COG0306 Phosphate sulphate permeases K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.000001888 50.0
HKD2_k127_7287588_3 Protein of unknown function (DUF998) - - - 0.0009344 46.0
HKD2_k127_728887_0 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007301 389.0
HKD2_k127_728887_1 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.0000000000000000000000000000000000000000000000000000002166 197.0
HKD2_k127_728887_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.00000000000000000000000000000000000000004047 158.0
HKD2_k127_728887_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.0000000000000000000000000000000000000003262 150.0
HKD2_k127_728887_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.000000000000000000000000000000002148 134.0
HKD2_k127_728887_5 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.00000000000000002466 84.0
HKD2_k127_7313979_0 Protein of unknown function, DUF255 K06888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000735 505.0
HKD2_k127_7313979_1 Belongs to the UPF0280 family K09740 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 290.0
HKD2_k127_7313979_2 - - - - 0.00000000000000000000000009597 111.0
HKD2_k127_7316023_0 PAC2 family K06869 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 347.0
HKD2_k127_7316023_1 Protein of unknown function (DUF473) K09135 - - 0.0000000000000000000000000000000000000008819 153.0
HKD2_k127_7316023_2 - - - - 0.0000000000000000000000000002264 117.0
HKD2_k127_7324312_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004546 377.0
HKD2_k127_7324312_1 bacterial-type flagellum-dependent cell motility - - - 0.0000000000002669 82.0
HKD2_k127_7334057_0 DNA polymerase beta domain protein region K09717 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003511 341.0
HKD2_k127_7334057_1 PFAM amino acid-binding ACT domain protein K06862 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 320.0
HKD2_k127_7334057_2 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000001174 239.0
HKD2_k127_7343470_0 Arginine deiminase K01478 - 3.5.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 339.0
HKD2_k127_7343470_1 Belongs to the carbamate kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 321.0
HKD2_k127_7343470_2 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 302.0
HKD2_k127_7343470_3 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000005546 184.0
HKD2_k127_7343470_4 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.0000000000000000000000000002969 117.0
HKD2_k127_7344877_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 557.0
HKD2_k127_7344877_1 PFAM SufBD protein K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005227 556.0
HKD2_k127_7344877_2 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 467.0
HKD2_k127_7344877_3 COG0863 DNA modification methylase K00571,K00590 - 2.1.1.113,2.1.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007087 450.0
HKD2_k127_7344877_4 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 339.0
HKD2_k127_7344877_5 ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000065 274.0
HKD2_k127_7344877_6 sugar phosphatases of the HAD superfamily K02566 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000076 259.0
HKD2_k127_7344877_7 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000001103 112.0
HKD2_k127_7344877_8 - - - - 0.00000000000000000000009428 106.0
HKD2_k127_7344877_9 Belongs to the UPF0434 family - - - 0.0000000000000000006486 87.0
HKD2_k127_7352205_0 Domain of unknown function DUF128 K21640 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002273 267.0
HKD2_k127_7352205_1 - - - - 0.000000000000000000002853 95.0
HKD2_k127_7357799_0 PFAM PP-loop domain protein - - - 0.000000000000000000007049 104.0
HKD2_k127_7357799_1 Rio2, N-terminal K07179 - 2.7.11.1 0.0000000000000005323 79.0
HKD2_k127_7372832_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 6.125e-282 882.0
HKD2_k127_7372832_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002919 310.0
HKD2_k127_7372832_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.0000000000000002657 79.0
HKD2_k127_7393147_0 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000007185 220.0
HKD2_k127_7393147_1 endonuclease III K01247 - 3.2.2.21 0.000001088 60.0
HKD2_k127_7398985_0 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 576.0
HKD2_k127_7398985_1 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000103 266.0
HKD2_k127_7398985_2 Belongs to the peptidase S16 family K04076 - 3.4.21.53 0.00000000000000000000000000003489 118.0
HKD2_k127_7413829_0 Pectate lyase K01728 - 4.2.2.2 0.00000000000000000000000000000000000000000001887 179.0
HKD2_k127_7416827_0 PFAM ABC-2 type transporter K09694 - - 0.0000000000000000000000000000000000000003716 151.0
HKD2_k127_7416827_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000004119 155.0
HKD2_k127_7426044_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 300.0
HKD2_k127_7426044_1 - - - - 0.00000000000000000000000000000002829 128.0
HKD2_k127_7435232_0 PFAM Rubrerythrin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001063 281.0
HKD2_k127_7435232_1 Dual specificity phosphatase, catalytic domain - - - 0.00000000000000002101 88.0
HKD2_k127_7435232_2 Psort location CytoplasmicMembrane, score 10.00 K03975 - - 0.000000000000001985 82.0
HKD2_k127_743661_0 transferase hexapeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008334 256.0
HKD2_k127_743661_1 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000004922 209.0
HKD2_k127_743661_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000002697 177.0
HKD2_k127_7438467_0 AAA domain - - - 3.53e-224 720.0
HKD2_k127_7438467_1 COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - 0.000000000000000000005159 96.0
HKD2_k127_7442865_0 Cache_2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004354 545.0
HKD2_k127_7442865_1 PFAM extracellular solute-binding protein family 3 K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002056 267.0
HKD2_k127_7442865_2 Histidine kinase K02480 - 2.7.13.3 0.0000000000002574 83.0
HKD2_k127_7450036_0 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000007998 155.0
HKD2_k127_7450036_1 GyrI-like small molecule binding domain - - - 0.00000000000000000000000000000000001446 140.0
HKD2_k127_7455143_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007597 450.0
HKD2_k127_7455143_1 Anaerobic ribonucleoside-triphosphate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000001608 217.0
HKD2_k127_7455143_2 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000002687 213.0
HKD2_k127_7455143_3 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000009099 71.0
HKD2_k127_7455143_4 Domain of unknown function DUF11 - - - 0.00000000001573 76.0
HKD2_k127_7486026_0 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 366.0
HKD2_k127_7486026_1 PFAM Radical SAM domain protein K07129 - - 0.0000000000000000000000000000000000000000000000000004404 188.0
HKD2_k127_7487586_0 Transport of potassium into the cell K03549 - - 8.317e-227 719.0
HKD2_k127_7487586_1 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00000000000000000000000000000000007206 137.0
HKD2_k127_7487940_0 PFAM respiratory-chain NADH dehydrogenase, subunit 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 340.0
HKD2_k127_7487940_1 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 0.000000000000000000000000000000000002479 139.0
HKD2_k127_7508244_0 MscS Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000009787 225.0
HKD2_k127_7508640_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K14126 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 353.0
HKD2_k127_7508640_1 F420-non-reducing hydrogenase subunit G K14128 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000001286 186.0
HKD2_k127_7520884_0 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 1.195e-195 614.0
HKD2_k127_7520884_1 Cell division protein 48 (CDC48), domain 2 K13525 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 368.0
HKD2_k127_7520884_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000009668 53.0
HKD2_k127_7585611_0 PFAM Sporulation protein YtfJ - - - 0.00000000000000000001105 96.0
HKD2_k127_7585611_1 Protein of unknown function (DUF2953) - - - 0.000000000000001553 85.0
HKD2_k127_7594421_0 PFAM TatD-related deoxyribonuclease K07049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008521 380.0
HKD2_k127_7594421_1 pfam nmd3 K07562 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 350.0
HKD2_k127_7594421_2 Protein of unknown function (DUF424) K09148 - - 0.0000000000000000000000000000003086 136.0
HKD2_k127_7594421_3 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.0000000000007607 68.0
HKD2_k127_7597617_0 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 8.321e-231 725.0
HKD2_k127_7597617_1 Domain of unknown function DUF87 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 481.0
HKD2_k127_7607243_0 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 455.0
HKD2_k127_7607243_1 PFAM Xylose isomerase domain protein TIM barrel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 347.0
HKD2_k127_7607243_2 adenyl ribonucleotide binding - - - 0.0000000000000000000000000000000000000000000000000000000000001965 219.0
HKD2_k127_7607243_3 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000000000000000002446 87.0
HKD2_k127_7615046_0 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000652 175.0
HKD2_k127_7615046_1 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000000000000000000000002201 128.0
HKD2_k127_7623756_0 nucleoside 2-deoxyribosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004829 302.0
HKD2_k127_7623756_1 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.000000000000000000000000000000000000000000000000000000000000000000001218 239.0
HKD2_k127_7623756_2 Site-specific DNA-methyltransferase (Adenine-specific) K06223 - 2.1.1.72 0.00001043 51.0
HKD2_k127_7623937_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 383.0
HKD2_k127_7632139_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 1.183e-198 625.0
HKD2_k127_7635593_0 Dihydrouridine synthase (Dus) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 510.0
HKD2_k127_7635593_1 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.00000000000000000000000000000000000002442 145.0
HKD2_k127_7635593_2 Domain of unknown function DUF11 - - - 0.000000000000000000000001055 116.0
HKD2_k127_7635902_0 PFAM PBS lyase HEAT-like repeat - - - 0.000000000000000000000000000000007066 135.0
HKD2_k127_7635902_1 - - - - 0.000001501 59.0
HKD2_k127_7643848_0 TIGRFAM TraB family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003729 474.0
HKD2_k127_7643848_1 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000001578 212.0
HKD2_k127_7643848_2 Belongs to the UPF0305 family - - - 0.0000000000000000000000000000000000000000000000003559 183.0
HKD2_k127_7643848_3 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000004836 117.0
HKD2_k127_7648811_0 PFAM Aminotransferase class I and II K10206 - 2.6.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 401.0
HKD2_k127_7648811_1 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000000004121 113.0
HKD2_k127_7651889_0 Belongs to the peptidase S8 family - - - 0.00000000102 70.0
HKD2_k127_7656125_0 CRISPR-associated protein Cas4 K07464 - 3.1.12.1 0.00000000000000000000000000000000000000000000000000000000000001178 223.0
HKD2_k127_7656125_1 Protein of unknown function (DUF3467) - - - 0.00000000000000000000000000000000001141 144.0
HKD2_k127_7656125_2 DNA polymerase beta domain protein region K09717 - - 0.000000000000000000000000000000001909 130.0
HKD2_k127_7656125_3 - - - - 0.0001 51.0
HKD2_k127_7665292_0 PFAM response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005479 329.0
HKD2_k127_7665292_1 Belongs to the peptidase S8 family K12287 - - 0.0000000000000009455 85.0
HKD2_k127_7665292_2 Tetratricopeptide repeat - - - 0.00000000000002255 79.0
HKD2_k127_7673298_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 499.0
HKD2_k127_7673298_1 Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000418 359.0
HKD2_k127_7673298_2 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 290.0
HKD2_k127_7673298_3 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001102 255.0
HKD2_k127_7673298_4 AIR synthase related protein domain protein K04655 - - 0.00000000000000000000000000000000000000000001525 165.0
HKD2_k127_7678027_0 PFAM dihydropteroate synthase, DHPS - - - 1.251e-203 643.0
HKD2_k127_7678027_1 PFAM peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004489 495.0
HKD2_k127_7678027_2 SMART phosphoesterase PHP domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007892 295.0
HKD2_k127_7678027_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000604 286.0
HKD2_k127_7678027_4 Tetratricopeptide repeat - - - 0.0000000000000000000001122 106.0
HKD2_k127_7678027_5 - - - - 0.000000000000000000000141 102.0
HKD2_k127_7678027_6 Protein of unknown function DUF89 K09116 - - 0.00000000000000004861 83.0
HKD2_k127_7681888_0 PFAM SufBD protein K07033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005101 331.0
HKD2_k127_7681888_1 ABC transporter K09013 - - 0.0000000000000000000000000000000000000000001453 162.0
HKD2_k127_7718681_0 KH, type 1, domain K07041 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 565.0
HKD2_k127_7718681_1 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001493 370.0
HKD2_k127_7718681_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 310.0
HKD2_k127_7732721_0 PFAM ABC transporter K00400 - - 5.986e-267 831.0
HKD2_k127_7732721_1 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000272 199.0
HKD2_k127_7732721_2 Belongs to the UPF0288 family - - - 0.0000000000000000000001473 102.0
HKD2_k127_7736604_0 PFAM amine oxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005885 474.0
HKD2_k127_7736604_1 TIGRFAM MIP family channel K02440,K06188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006816 296.0
HKD2_k127_7743112_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005611 531.0
HKD2_k127_7748158_0 integral membrane protein - - - 0.00000000000000000000000000000000000002226 149.0
HKD2_k127_7748158_1 RDD family - - - 0.00000000000000001036 91.0
HKD2_k127_7764836_0 PFAM Cation K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004404 385.0
HKD2_k127_7765702_0 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 4.732e-212 671.0
HKD2_k127_7765702_1 Threonyl-tRNA synthetase K01868 - 6.1.1.3 0.00000000000000000000000002958 110.0
HKD2_k127_7765702_2 PFAM Cys Met metabolism K01740 - 2.5.1.49 0.00000000004284 64.0
HKD2_k127_778918_0 Belongs to the carbohydrate kinase PfkB family K00852,K22026 - 2.7.1.15,2.7.1.213,2.7.1.73 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 379.0
HKD2_k127_778918_1 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006012 244.0
HKD2_k127_778918_2 Belongs to the UPF0212 family K09731 - - 0.0000000000000000000000000000000000000000000001283 173.0
HKD2_k127_778918_3 Family of unknown function (DUF5350) - - - 0.0000000000000000000000001181 111.0
HKD2_k127_778918_4 Predicted membrane protein (DUF2070) K08979 - - 0.00001324 50.0
HKD2_k127_7791152_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 440.0
HKD2_k127_7791152_1 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.000000000000000000000000000000000000000000000000000000000000000001587 230.0
HKD2_k127_7791152_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000002521 220.0
HKD2_k127_7796792_0 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 368.0
HKD2_k127_7796792_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000003195 144.0
HKD2_k127_7796792_2 - - - - 0.0000000000000001436 80.0
HKD2_k127_7810614_0 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002265 458.0
HKD2_k127_7810614_1 - - - - 0.000000000000000000000000000000001503 132.0
HKD2_k127_7814671_0 domain, Protein K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000547 551.0
HKD2_k127_7814671_1 PFAM sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 550.0
HKD2_k127_7814671_2 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003903 258.0
HKD2_k127_7814671_3 - - - - 0.0000000000000000001877 95.0
HKD2_k127_7814671_4 - - - - 0.0000003738 56.0
HKD2_k127_7824704_0 PFAM Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002511 264.0
HKD2_k127_7827870_0 Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008964 264.0
HKD2_k127_7827870_1 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.00000000000000000000000000006744 124.0
HKD2_k127_7830443_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 445.0
HKD2_k127_7833349_0 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004017 338.0
HKD2_k127_7833349_1 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001846 323.0
HKD2_k127_7833349_2 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000000000000000000000001057 262.0
HKD2_k127_7833349_3 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934 - 2.1.1.131 0.0000000000000000000000000000000000000000000000000000000001335 207.0
HKD2_k127_7833349_4 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.0000000000000000000000000000000000000000000000000002732 190.0
HKD2_k127_7833349_5 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000000000000000000000000000000000000000000006449 173.0
HKD2_k127_7834134_0 PFAM NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 323.0
HKD2_k127_7837982_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1198.0
HKD2_k127_7843429_0 COG1668 ABC-type Na efflux pump, permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 503.0
HKD2_k127_7843429_1 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000003585 224.0
HKD2_k127_7843724_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008646 430.0
HKD2_k127_7843724_1 Archaeal Nre, N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 326.0
HKD2_k127_7843724_2 Ferredoxin K05337 - - 0.000000000000000000000001314 109.0
HKD2_k127_7843724_3 Ferredoxin K05337 - - 0.0000000000000003164 82.0
HKD2_k127_7847483_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 9.293e-306 955.0
HKD2_k127_7847483_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 5.266e-196 619.0
HKD2_k127_7850272_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 4.755e-196 620.0
HKD2_k127_7850272_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 297.0
HKD2_k127_7850272_2 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000002379 200.0
HKD2_k127_7850272_3 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.000000000000005589 76.0
HKD2_k127_7873091_0 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 293.0
HKD2_k127_7873091_1 Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule - - - 0.000000000000000000000004082 104.0
HKD2_k127_7873091_2 - - - - 0.000000000000000009446 85.0
HKD2_k127_7897318_0 Predicted metal-binding protein (DUF2284) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 345.0
HKD2_k127_7897318_1 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.0000000000000000000000000000000000000000000000000000004875 196.0
HKD2_k127_7897318_2 Prokaryotic homologs of the JAB domain - - - 0.00000000000000000000000004715 107.0
HKD2_k127_7897982_0 transcription termination protein NusA K02600 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000003207 170.0
HKD2_k127_7897982_1 phosphoribosyl-ATP pyrophosphohydrolase K01523 - 3.6.1.31 0.000000000000000000000000000001635 123.0
HKD2_k127_7898851_0 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008077 248.0
HKD2_k127_7927140_0 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008605 547.0
HKD2_k127_7948678_0 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 341.0
HKD2_k127_7948678_1 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000000000000000000003658 151.0
HKD2_k127_7948678_2 peptide deformylase activity K01462 - 3.5.1.88 0.00000000000000000004652 96.0
HKD2_k127_7948678_3 - - - - 0.0000002088 55.0
HKD2_k127_798827_0 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008741 583.0
HKD2_k127_798827_1 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.0000000000000000000000000000000000000000000000000000007536 194.0
HKD2_k127_798827_2 helicase activity K06915 - - 0.00000000000000000000002814 111.0
HKD2_k127_7989031_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000653 596.0
HKD2_k127_7989031_1 FeS cluster assembly scaffold protein NifU K04488 - - 0.000000000000000000000000000000000000000000000000000000000000000001806 231.0
HKD2_k127_7989031_2 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000001045 199.0
HKD2_k127_7989031_3 Transcriptional regulator K07108 - - 0.00000000000000000000000000000002696 128.0
HKD2_k127_7989031_4 PP-loop domain protein K06864 - - 0.00000000001364 68.0
HKD2_k127_7994007_0 Domain of unknown function (DUF373) K08975 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007055 431.0
HKD2_k127_7994007_1 - - - - 0.000000002566 59.0
HKD2_k127_7994314_0 PFAM Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 1.942e-213 681.0
HKD2_k127_7994314_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000000001165 134.0
HKD2_k127_799518_0 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 394.0
HKD2_k127_799518_1 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 379.0
HKD2_k127_799518_2 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 356.0
HKD2_k127_799518_3 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007376 302.0
HKD2_k127_799518_4 PFAM CBS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001911 284.0
HKD2_k127_799518_5 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000005352 229.0
HKD2_k127_799518_6 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.000000000000000000000000000000000000000000000000008141 187.0
HKD2_k127_799518_7 PFAM GTP-binding protein HSR1-related K06883 - - 0.00000006473 55.0
HKD2_k127_8004967_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta complex) K00193 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008804 338.0
HKD2_k127_8004967_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.0000000000000000000000000000000000005251 148.0
HKD2_k127_8020838_0 Domain of unknown function (DUF296) K06934 - - 0.00000000000000000000000000000000000000000000009913 175.0
HKD2_k127_8020838_1 PFAM peptidase U32 K08303 - - 0.0000000000000000000007112 97.0
HKD2_k127_8025403_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005507 460.0
HKD2_k127_8025403_1 TIGRFAM small GTP-binding protein K06943 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 372.0
HKD2_k127_8025403_2 SMART Peptidase A22, presenilin signal peptide - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 317.0
HKD2_k127_8025403_3 signal transduction protein with CBS domains K07744 - - 0.000000000000000000000000000000000000000000000000000002049 192.0
HKD2_k127_8025403_4 - - - - 0.000000000000000000000000007026 116.0
HKD2_k127_8032822_0 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003705 289.0
HKD2_k127_8032822_1 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.000000000000000000000000000000000000002049 152.0
HKD2_k127_8034900_0 Protein of unknown function (DUF2769) - - - 0.0000000000000000000000000000000001085 135.0
HKD2_k127_8034900_1 Domain of unknown function (DUF4962) - - - 0.00000000000000000000000000007033 136.0
HKD2_k127_8034900_2 ATP cone domain - - - 0.0000000000000000000000000756 108.0
HKD2_k127_8034900_3 Rieske-like [2Fe-2S] domain - - - 0.00000000000000001102 92.0
HKD2_k127_8057489_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 516.0
HKD2_k127_8062799_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 6.769e-241 752.0
HKD2_k127_8062799_1 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 320.0
HKD2_k127_8062799_2 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000001291 218.0
HKD2_k127_8065842_0 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000643 527.0
HKD2_k127_8065842_1 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000000000000000000000002464 224.0
HKD2_k127_8077586_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002486 527.0
HKD2_k127_8077586_1 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008901 366.0
HKD2_k127_8089537_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000002735 233.0
HKD2_k127_8089537_1 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000000000000000000002995 213.0
HKD2_k127_8089537_2 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000001142 194.0
HKD2_k127_8089537_3 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.0000000000000000000000000000000000000000000001118 171.0
HKD2_k127_8089537_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.000000000000000000000000000001438 123.0
HKD2_k127_8089537_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.0000000000000000000229 91.0
HKD2_k127_8109263_0 PFAM CBS domain - - - 3.713e-240 751.0
HKD2_k127_8109263_1 NIF3 (NGG1p interacting factor 3) - - - 0.000000000000000000000000000000000000000000000004776 181.0
HKD2_k127_8109263_2 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000006439 179.0
HKD2_k127_8111019_0 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 360.0
HKD2_k127_8111019_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000001567 197.0
HKD2_k127_8111019_2 PFAM Semialdehyde dehydrogenase NAD - binding K00133 - 1.2.1.11 0.0000000000000000000000000000000000004408 141.0
HKD2_k127_8111019_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000005986 93.0
HKD2_k127_8133507_0 Catalyzes the reversible phosphorylation of UMP to UDP K00947 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 424.0
HKD2_k127_8133507_1 PFAM Bacterial regulatory protein, arsR family - - - 0.0000000000000000000000000006088 115.0
HKD2_k127_8133507_2 - - - - 0.00000000000000000000591 94.0
HKD2_k127_8149181_0 Ferritin-like domain K02217 - 1.16.3.2 0.0000000000000000000000000000000000000000000000000002383 191.0
HKD2_k127_8149181_1 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000004709 150.0
HKD2_k127_8158174_0 acetyl-CoA carboxylase, biotin carboxylase K01959 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 555.0
HKD2_k127_8158174_1 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.00000000000000000000000000000000000000000000000000000000000002335 218.0
HKD2_k127_8201687_0 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001194 267.0
HKD2_k127_821041_0 Creatinase/Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 506.0
HKD2_k127_8218146_0 PFAM Protein kinase domain - - - 0.000000000000000000000003784 109.0
HKD2_k127_8218146_1 Right handed beta helix region - - - 0.0000000000000003659 88.0
HKD2_k127_8229952_0 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003283 312.0
HKD2_k127_8253526_0 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005413 266.0
HKD2_k127_8258854_0 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 521.0
HKD2_k127_8258854_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.00000000000000000000000001001 109.0
HKD2_k127_8258854_2 - - - - 0.00000001368 58.0
HKD2_k127_8300108_0 Peptidase M50 - - - 0.00000000000000000000000000000000000000000000004033 179.0
HKD2_k127_8300108_1 chorismate mutase K04093 - 5.4.99.5 0.00000000000000000000000769 104.0
HKD2_k127_8300108_2 Predicted membrane protein (DUF2207) - - - 0.0000001646 54.0
HKD2_k127_8300936_0 domain, Protein - - - 0.000000000000000000000000000000000000000003026 167.0
HKD2_k127_8338223_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 1.172e-229 722.0
HKD2_k127_8338223_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000008273 158.0
HKD2_k127_8357608_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 4.52e-197 621.0
HKD2_k127_8381056_0 ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates K03420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 450.0
HKD2_k127_8381056_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 328.0
HKD2_k127_8381056_2 Helix-turn-helix domain protein K03627 - - 0.00000000000000000000000000000000000000000005498 165.0
HKD2_k127_8433237_0 Fumarase C C-terminus K01679,K01744 - 4.2.1.2,4.3.1.1 6.636e-195 623.0
HKD2_k127_8433237_1 COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 292.0
HKD2_k127_8433237_2 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000001275 214.0
HKD2_k127_8433237_4 Extradiol ring-cleavage dioxygenase K15777 - - 0.0000000000000006009 87.0
HKD2_k127_8462553_0 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 444.0
HKD2_k127_8462553_1 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000001023 117.0
HKD2_k127_8462553_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000001192 74.0
HKD2_k127_8462553_3 PFAM PEGA domain - - - 0.000007136 58.0
HKD2_k127_8468886_0 DEAD DEAH box helicase domain protein K03724 - - 0.00000000000000004648 80.0
HKD2_k127_8468886_1 Short repeat of unknown function (DUF308) - - - 0.00002655 53.0
HKD2_k127_8505167_0 N-formylglutamate amidohydrolase K01479 - 3.5.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 308.0
HKD2_k127_8505167_1 PFAM Isochorismatase - - - 0.000000000000000000000000000000000000000000000000000000000000000001297 233.0
HKD2_k127_8550243_0 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.0000000000000000000000000000000000000000000000000000000000000000002391 233.0
HKD2_k127_8550243_1 PFAM glutamate--cysteine ligase, GCS2 - - - 0.0000000000000000000000000000000000000000000008107 179.0
HKD2_k127_8550243_2 Citrate transporter - - - 0.0000000000000000000000000001508 117.0
HKD2_k127_8575844_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008067 394.0
HKD2_k127_8584516_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 2.37e-244 759.0
HKD2_k127_8584516_1 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004791 272.0
HKD2_k127_8602001_0 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000000000000000000000000000003746 205.0
HKD2_k127_8602001_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000000000000619 183.0
HKD2_k127_8602001_2 - - - - 0.00000007876 59.0
HKD2_k127_8618493_0 in RNase L inhibitor, RLI K06174 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 510.0
HKD2_k127_8618493_1 Domain of unknown function (DUF814) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 319.0
HKD2_k127_8618493_2 RNase L inhibitor, RLI - - - 0.000000000000000000001821 101.0
HKD2_k127_8664239_0 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 332.0
HKD2_k127_8664239_1 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 - - 0.00000000000000000000000000000000000000000001741 168.0
HKD2_k127_8667366_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 2.67e-232 750.0
HKD2_k127_8667366_1 Sodium hydrogen exchanger K03455 - - 8.63e-209 669.0
HKD2_k127_8667366_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000002927 70.0
HKD2_k127_8667366_3 nucleotidyltransferase activity - - - 0.000000000004366 74.0
HKD2_k127_8693370_0 ABC transporter transmembrane region K06147,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 315.0
HKD2_k127_8696743_0 DEAD DEAH box helicase domain protein K03724 - - 3.251e-288 895.0
HKD2_k127_8700053_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 487.0
HKD2_k127_8713259_0 MafB19-like deaminase - - - 0.0000000000000000000000000000000000000000000000000000000000000008322 222.0
HKD2_k127_8713259_1 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000001289 168.0
HKD2_k127_8713259_2 SnoaL-like domain - - - 0.00000000000000000000000001162 115.0
HKD2_k127_8713259_3 Antibiotic biosynthesis monooxygenase - - - 0.000000000000004324 80.0
HKD2_k127_8742437_0 PBS lyase HEAT-like repeat - - - 0.000000000000000000000000000000000000000000000000012 190.0
HKD2_k127_8742437_1 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000001499 144.0
HKD2_k127_8753908_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 481.0
HKD2_k127_8753908_1 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.000000000000000000000000000000000000000000000000000000001987 203.0
HKD2_k127_8785602_0 Winged helix-turn-helix - - - 0.0000000000000000000000000000000001347 140.0
HKD2_k127_8785602_1 - - - - 0.00000000000000000000002447 106.0
HKD2_k127_8785602_2 ATP synthase subunit C K02124 - - 0.0000000000000000000001919 99.0
HKD2_k127_8797811_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009542 539.0
HKD2_k127_8797811_1 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K19244 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006556 413.0
HKD2_k127_8797811_2 PFAM Radical SAM domain protein K06937 - - 0.0000000000000000000000000000000000000000000000000000000004234 203.0
HKD2_k127_8797811_3 Uncharacterised protein family UPF0058 - - - 0.000000000000000000000000000000000000000373 152.0
HKD2_k127_87998_0 N-6 DNA Methylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003791 282.0
HKD2_k127_87998_1 Belongs to the TPP enzyme family K00158 - 1.2.3.3 0.000000000000000000000000000002663 121.0
HKD2_k127_8804297_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000324 231.0
HKD2_k127_8804569_0 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 353.0
HKD2_k127_8809466_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007903 285.0
HKD2_k127_8809466_1 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002858 278.0
HKD2_k127_8809466_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000613 143.0
HKD2_k127_8809466_3 F420-non-reducing hydrogenase subunit G K14128 - 1.8.98.5 0.0000000000000000000000000003218 114.0
HKD2_k127_8809466_4 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.0000000000000000000000008919 104.0
HKD2_k127_8816350_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1304.0
HKD2_k127_8816350_1 Integral membrane protein DUF92 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 331.0
HKD2_k127_8816350_2 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003082 271.0
HKD2_k127_8816350_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000001562 231.0
HKD2_k127_8816350_4 PFAM thymidylate kinase K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000001206 172.0
HKD2_k127_8825877_0 COG1226 Kef-type K transport systems K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007725 287.0
HKD2_k127_8825877_1 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000001275 151.0
HKD2_k127_8827964_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 2.604e-321 994.0
HKD2_k127_8827964_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 349.0
HKD2_k127_8834727_0 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 522.0
HKD2_k127_8834727_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 302.0
HKD2_k127_8834727_2 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000000000000000000000000001266 187.0
HKD2_k127_8841800_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 1.794e-308 959.0
HKD2_k127_8841800_1 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 422.0
HKD2_k127_8841800_2 Belongs to the LDH MDH superfamily K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 326.0
HKD2_k127_8841800_3 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 317.0
HKD2_k127_8853163_0 - - - - 0.000000000000000000008151 95.0
HKD2_k127_8853163_1 PFAM helix-turn-helix domain protein K07729 - - 0.0000000000008375 69.0
HKD2_k127_886442_0 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002742 466.0
HKD2_k127_886442_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006773 472.0
HKD2_k127_886442_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 350.0
HKD2_k127_886442_3 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 333.0
HKD2_k127_886442_4 PFAM sigma-70 region 4 domain protein K09714 - - 0.00000000000000000000000000000000000000000000000000000000000000006154 224.0
HKD2_k127_886442_5 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000000000000000000006173 218.0
HKD2_k127_886442_6 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000000000008523 196.0
HKD2_k127_886442_7 Binds the lower part of the 30S subunit head K02982 - - 0.0000000000000000000000000000000000000000000000009851 179.0
HKD2_k127_886442_8 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.000000000000000000000000009049 111.0
HKD2_k127_8882385_0 PFAM ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007868 337.0
HKD2_k127_8882385_1 permease K03299 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001856 314.0
HKD2_k127_8882385_2 PFAM ABC transporter related K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005223 241.0
HKD2_k127_8882385_3 signal-transduction protein containing cAMP-binding and CBS domains K01425 GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 3.5.1.2 0.0000000000000000000000000000000008141 134.0
HKD2_k127_8882385_4 PFAM PQ loop repeat K15383 - - 0.00000005879 59.0
HKD2_k127_8891650_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382,K00383 - 1.8.1.4,1.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 479.0
HKD2_k127_8891650_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004308 258.0
HKD2_k127_8891650_2 COG1361 S-layer domain - - - 0.0000000000000000000000000000000000000000000000000000006733 200.0
HKD2_k127_8907718_0 With S4 and S12 plays an important role in translational accuracy K02988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 336.0
HKD2_k127_8907718_1 TIGRFAM ribosomal protein L30P K02907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001047 251.0
HKD2_k127_8907718_2 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000000000000000000000000005743 237.0
HKD2_k127_8907718_3 binds to the 23S rRNA K02885 - - 0.0000000000000000002298 88.0
HKD2_k127_8911456_0 Uncharacterised nucleotidyltransferase - - - 0.0000000005109 70.0
HKD2_k127_8911456_1 signal peptide processing K00564,K13280 - 2.1.1.172,3.4.21.89 0.00001045 51.0
HKD2_k127_8940123_0 PFAM amino acid permease-associated region K20265 - - 6.709e-230 719.0
HKD2_k127_8940123_1 - - - - 0.000000000000000000000001234 109.0
HKD2_k127_8940123_2 Orn/Lys/Arg decarboxylase, C-terminal domain K01584 - 4.1.1.19 0.00000000000005362 72.0
HKD2_k127_8949232_0 TIGRFAM mannose-1-phosphate guanylyltransferase mannose-6-phosphate isomerase K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009496 587.0
HKD2_k127_8968154_0 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007116 381.0
HKD2_k127_8968154_1 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000978 327.0
HKD2_k127_8968154_2 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000001258 220.0
HKD2_k127_9024428_0 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 7.757e-197 620.0
HKD2_k127_9056864_0 PFAM ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007894 465.0
HKD2_k127_9056864_1 asparagine synthase - - - 0.0000000000000000000001386 108.0
HKD2_k127_9070298_0 - K03561,K12287 - - 0.000000000000000000000000000000000000000000000000001091 201.0
HKD2_k127_9081068_0 Transcriptional regulator K07722 - - 0.0000000000000000000000000000000000000000000000000000000000000003773 222.0
HKD2_k127_9081068_1 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.0000000000000000000000000000000000000000000006379 170.0
HKD2_k127_9081068_2 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.0000000000000006002 87.0
HKD2_k127_9090369_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006453 541.0
HKD2_k127_9090369_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000004493 232.0
HKD2_k127_9153871_0 PFAM oxidoreductase nitrogenase, component 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006368 358.0
HKD2_k127_9153871_1 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000016 309.0
HKD2_k127_9153871_2 PFAM oxidoreductase nitrogenase, component 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000376 273.0
HKD2_k127_9153871_3 light absorption K06893 - - 0.0000000000000000000000000000000001415 136.0
HKD2_k127_9160401_0 PFAM multi antimicrobial extrusion protein MatE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008415 380.0
HKD2_k127_9177596_0 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 458.0
HKD2_k127_9177596_1 PFAM respiratory-chain NADH dehydrogenase, subunit 1 - - - 0.000000000000000000000000000000000000000000000000000000000000001215 224.0
HKD2_k127_9182979_0 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 442.0
HKD2_k127_9183698_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003163 592.0
HKD2_k127_9183698_1 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000001508 235.0
HKD2_k127_9183698_2 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.000000000000000000000000007478 116.0
HKD2_k127_9183735_0 PFAM tRNA synthetase, class II (G, H, P and S) K01880 - 6.1.1.14 1.684e-271 845.0
HKD2_k127_9183735_1 DEAD DEAH box helicase domain protein K10896 - - 6.274e-239 754.0
HKD2_k127_9183735_2 Belongs to the UPF0173 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004723 317.0
HKD2_k127_9183735_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001263 303.0
HKD2_k127_9183735_4 serine-type endopeptidase activity - - - 0.00000000000000000000000000000006255 137.0
HKD2_k127_9183735_5 Secreted repeat of unknown function - - - 0.0000000000000000000000002594 108.0
HKD2_k127_926039_0 Heat shock 70 kDa protein K04043 - - 2.919e-297 923.0
HKD2_k127_926039_1 TIGRFAM phosphoribosylaminoimidazolecarboxamide formyltransferase IMP cyclohydrolase K00602 - 2.1.2.3,3.5.4.10 2.485e-203 643.0
HKD2_k127_926039_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000291 501.0
HKD2_k127_926039_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000001506 145.0
HKD2_k127_9283857_0 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002289 322.0
HKD2_k127_9283857_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.0000000000000000000000000000000000000000000000000000000000000000000000000003938 261.0
HKD2_k127_9283857_2 Tetratricopeptide repeat - - - 0.0001233 46.0
HKD2_k127_9304848_0 - - - - 0.000000000000000000000000000000000000000000188 163.0
HKD2_k127_9304848_1 - - - - 0.00000000000000000000000005149 114.0
HKD2_k127_9308886_0 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 5.061e-229 722.0
HKD2_k127_9308886_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 288.0
HKD2_k127_9308886_2 - - - - 0.00000000000000000000000000003056 126.0
HKD2_k127_9308886_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000005108 111.0
HKD2_k127_9322038_0 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004122 466.0
HKD2_k127_9327146_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008134 560.0
HKD2_k127_9327146_1 PFAM thiamine pyrophosphate enzyme K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 292.0
HKD2_k127_9327146_2 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.000000000000000000000000000000000000002075 155.0
HKD2_k127_9341263_0 Dehydrogenase E1 component K00164,K01616 GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005598 524.0
HKD2_k127_9349206_0 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000002452 244.0
HKD2_k127_9349206_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.000000000000000000000000000000000000000000000000000000000000000009536 229.0
HKD2_k127_9360715_0 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 517.0
HKD2_k127_9360715_1 HTH-type transcriptional regulatory protein K07728 - - 0.0000621 48.0
HKD2_k127_9387457_0 Belongs to the archaeal adenylate kinase family K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000001844 265.0
HKD2_k127_9387457_1 Integral membrane protein DUF106 - - - 0.00000000000000000000000000000000000000000000000000000000000000002475 232.0
HKD2_k127_9387457_2 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000003635 222.0
HKD2_k127_9387457_3 - - - - 0.000003246 57.0
HKD2_k127_9408995_0 Calcineurin-like phosphoesterase K07098 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006367 320.0
HKD2_k127_9408995_1 META domain - - - 0.00000000000001065 86.0
HKD2_k127_9408995_2 Heat shock protein K03668 - - 0.0000006256 61.0
HKD2_k127_9413463_0 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005579 573.0
HKD2_k127_9413463_1 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 408.0
HKD2_k127_9413463_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 373.0
HKD2_k127_9413463_3 PFAM Haloacid dehalogenase domain protein hydrolase K17686 - 3.6.3.54 0.0001919 44.0
HKD2_k127_94461_0 Replication factor C K04801 - - 0.000000000000000000000000000000000000000000000000000000000000000001191 233.0
HKD2_k127_94461_1 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000002067 171.0
HKD2_k127_94461_2 PFAM AIR synthase related protein K07388 - - 0.000006434 48.0
HKD2_k127_9471312_0 PFAM elongation factor Tu domain 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 338.0
HKD2_k127_9471312_1 UbiA prenyltransferase family - - - 0.0000000000000000000000000000000000000005919 153.0
HKD2_k127_9471312_2 UbiA prenyltransferase family - - - 0.0000000000003621 69.0
HKD2_k127_9471312_3 Domain of unknown function (DUF362) - - - 0.0000000001486 65.0
HKD2_k127_94941_0 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 298.0
HKD2_k127_94941_1 PhoU domain - - - 0.000000000000000000000000000000000000000000000000000000000000000003392 230.0
HKD2_k127_9503972_0 Serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008421 340.0
HKD2_k127_9503972_1 Protein phosphatase 2C - - - 0.000000000000000000000000000000000000000000000000000000000000000000008355 243.0
HKD2_k127_9518798_0 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008216 484.0
HKD2_k127_9518798_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000001491 124.0
HKD2_k127_9530862_0 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 523.0
HKD2_k127_9530862_1 PFAM LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006108 271.0
HKD2_k127_9531265_0 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 573.0
HKD2_k127_9531265_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007925 426.0
HKD2_k127_9531265_2 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003815 332.0
HKD2_k127_9531265_3 Fumarase C-terminus K01678 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000009548 261.0
HKD2_k127_9531265_4 Oxidoreductase K00177 - 1.2.7.3 0.00000000000000000000000000000000000000000000006803 172.0
HKD2_k127_9531265_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00176 - 1.2.7.3 0.00000000000000000000000000000000000000002046 154.0
HKD2_k127_9565193_0 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 416.0
HKD2_k127_956605_0 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 1.66e-209 668.0
HKD2_k127_956605_1 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 505.0
HKD2_k127_956605_2 PFAM oxidoreductase domain protein K18855 - 1.1.1.374 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002955 295.0
HKD2_k127_956605_3 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000001557 271.0
HKD2_k127_9582281_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 564.0
HKD2_k127_9582281_1 Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K02303 GO:0003674,GO:0003824,GO:0004851,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008757,GO:0009058,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019354,GO:0019438,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000007954 251.0
HKD2_k127_9583142_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 449.0
HKD2_k127_9583142_1 TIGRFAM hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000007406 98.0
HKD2_k127_9583142_2 Belongs to the UPF0235 family K09131 - - 0.0000000000000906 76.0
HKD2_k127_9598063_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000002609 141.0
HKD2_k127_9598063_1 PFAM Yip1 domain - - - 0.00000000000001751 82.0
HKD2_k127_9632915_0 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 354.0
HKD2_k127_9632915_1 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004722 276.0
HKD2_k127_9632915_2 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.00000000000000000000000000000000000000000000000000000000001854 211.0
HKD2_k127_9632915_3 Tetrapyrrole (Corrin/Porphyrin) Methylases K05934,K13541 - 2.1.1.131,3.7.1.12 0.0000000000000000000000000944 111.0
HKD2_k127_9638622_0 SMART Elongator protein 3 MiaB NifB - - - 5.714e-232 730.0
HKD2_k127_9638622_1 phosphoesterase RecJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 488.0
HKD2_k127_9638622_2 Belongs to the peptidase M50B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 463.0
HKD2_k127_9638622_3 ABC-2 family transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000478 422.0
HKD2_k127_9638622_4 tRNAHis guanylyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 327.0
HKD2_k127_9638622_5 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000000000000000000000000006606 255.0
HKD2_k127_9638622_6 COG1668 ABC-type Na efflux pump, permease component - - - 0.00000000000000000000000000000000000000000000000000000001358 202.0
HKD2_k127_9638622_7 PFAM PRC-barrel domain - - - 0.00000000000000000000000000001942 119.0
HKD2_k127_9638622_8 - - - - 0.000000000000006255 80.0
HKD2_k127_9645196_0 Domain of unknown function (DUF4349) - - - 0.00000000000000000000000000000000000000000000000007759 187.0
HKD2_k127_9645196_1 Protein tyrosine kinase - - - 0.000000000000000000000001039 111.0
HKD2_k127_9658092_0 TIGRFAM histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 2.299e-215 679.0
HKD2_k127_9658092_1 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 447.0
HKD2_k127_9658092_2 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004951 313.0
HKD2_k127_9658092_3 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002067 267.0
HKD2_k127_9658092_4 Belongs to the UPF0179 family K09730 - - 0.0000000000000000000000000000000000000000000000000000000004988 216.0
HKD2_k127_9658092_5 metal-binding protein - - - 0.0000000000000000000008497 109.0
HKD2_k127_9660121_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 1.379e-262 815.0
HKD2_k127_9685167_0 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 381.0
HKD2_k127_9685167_1 - - - - 0.0000000005811 60.0
HKD2_k127_9689740_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 5.558e-196 621.0
HKD2_k127_9700975_0 Molybdopterin converting factor K03635 - 2.8.1.12 0.000000000000000000000000000000000000001367 153.0
HKD2_k127_9700975_1 Molybdopterin converting factor, small subunit K03636 - - 0.0000000000000000001623 91.0
HKD2_k127_9715041_0 NMT1-like family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009953 441.0
HKD2_k127_9715041_1 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 369.0
HKD2_k127_9715041_2 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 340.0
HKD2_k127_9767809_0 Catalyzes the deamination of 5'-deoxyadenosine into 5'- deoxyinosine. May be involved in the recycling of 5'- deoxyadenosine, whereupon the 5'-deoxyribose moiety of 5'- deoxyinosine is further metabolized to deoxyhexoses used for the biosynthesis of aromatic amino acids in methanogens. Is also able to deaminate 5-methylthioadenosine, S-adenosyl-L-homocysteine and adenosine to a small extent K12960 GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0050270 3.5.4.28,3.5.4.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000684 566.0
HKD2_k127_9773764_0 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 314.0
HKD2_k127_9773764_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000268 231.0
HKD2_k127_978406_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009221 483.0
HKD2_k127_978406_1 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 381.0
HKD2_k127_9805460_0 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.000000000000000000000000000000000000000000000000000179 203.0
HKD2_k127_9819516_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000002292 241.0
HKD2_k127_9819516_1 PFAM carbonic anhydrase K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000027 230.0
HKD2_k127_9819516_2 - - - - 0.000000000000000000000000000000004862 131.0
HKD2_k127_986368_0 COG1982 Arginine lysine ornithine decarboxylases K01581,K01584 - 4.1.1.17,4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 452.0
HKD2_k127_9871603_0 Stage II sporulation protein E K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 537.0
HKD2_k127_9871603_1 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like - - - 0.00000000000000308 79.0
HKD2_k127_9885412_0 acid binding OB-fold tRNA helicase-type K07463 - - 7.871e-283 882.0
HKD2_k127_9885412_1 - - - - 0.00000000000000000000000000000000004559 136.0
HKD2_k127_9885412_2 - - - - 0.00000000002335 70.0
HKD2_k127_9898289_0 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000001813 237.0
HKD2_k127_9898289_1 PFAM Metal-dependent phosphohydrolase, HD K06951 - - 0.00000000000000000000000000000000000000000000000000000000000002455 220.0
HKD2_k127_9900449_0 COG0607 Rhodanese-related sulfurtransferase K01011,K01069 - 2.8.1.1,2.8.1.2,3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 459.0
HKD2_k127_9900449_1 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively - - - 0.0000000000000000000000000000001146 127.0
HKD2_k127_9900607_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005527 455.0
HKD2_k127_9907815_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 551.0
HKD2_k127_9907815_1 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 518.0
HKD2_k127_9907815_2 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.000000000000000000000000000000000000000000000518 169.0
HKD2_k127_9926652_0 PFAM Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000348 594.0
HKD2_k127_9926652_1 transporter K07238,K11021 - - 0.000000000000000000000001509 107.0
HKD2_k127_9946243_0 Membrane bound hydrogenase subunit K18016 - 1.12.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004502 499.0
HKD2_k127_9946243_1 PFAM NADH dehydrogenase (ubiquinone), 30 kDa subunit K18017 - 1.12.7.2 0.00000000000000000000002616 107.0
HKD2_k127_9951269_0 PFAM ferredoxin-dependent glutamate synthase - - - 2.804e-294 908.0
HKD2_k127_9951269_1 TIR domain - - - 0.00000000000001334 80.0
HKD2_k127_9953533_0 PHP C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 463.0
HKD2_k127_9953533_1 Translation initiation factor 2 alpha subunit K03237 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 364.0
HKD2_k127_9953533_2 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 295.0
HKD2_k127_9953533_3 amino acid K16263 - - 0.0000000000000000000000000000000000000000000000000000000000000000001919 243.0
HKD2_k127_9953533_4 protein conserved in archaea K09723 - - 0.0000000000000000000000000000000000000000000001051 177.0
HKD2_k127_9953533_5 binds to the 23S rRNA K02929 - - 0.000000000000000000000000000000000000000000004906 171.0
HKD2_k127_9953533_6 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.0000000000000000000000000000000001751 134.0
HKD2_k127_9953533_7 PFAM Ribosomal protein S27E K02978 - - 0.0000000000000000000000005899 110.0
HKD2_k127_9953533_8 - - - - 0.00000000000002491 80.0
HKD2_k127_9953533_9 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.0000000000002318 74.0
HKD2_k127_9965813_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.456e-218 694.0
HKD2_k127_9965813_1 Membrane protein of unknown function DUF63 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 315.0
HKD2_k127_9965813_2 - - - - 0.00000000000000000000000000000000000000000001368 166.0
HKD2_k127_9965813_3 Stage II sporulation protein M K06384 - - 0.000000000000000000000000000000000000009512 152.0
HKD2_k127_9965813_4 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.00000000000000000001587 92.0