Overview

ID MAG01783
Name HKD2_bin.24
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Nitrospirota
Class Thermodesulfovibrionia
Order Thermodesulfovibrionales
Family SM23-35
Genus UBA2194
Species
Assembly information
Completeness (%) 89.45
Contamination (%) 5.65
GC content (%) 49.0
N50 (bp) 8,185
Genome size (bp) 1,914,505

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1911

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10091308_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007104 460.0
HKD2_k127_10091308_1 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004141 416.0
HKD2_k127_10091308_2 TIGRFAM daunorubicin resistance ABC transporter ATPase subunit K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006412 315.0
HKD2_k127_10091308_3 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000002259 229.0
HKD2_k127_10091308_4 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000009793 175.0
HKD2_k127_10091308_5 Auxiliary transport protein, membrane fusion protein (MFP) family protein K01993 - - 0.00000000000000004342 87.0
HKD2_k127_10123216_0 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 332.0
HKD2_k127_10123216_1 PFAM adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005844 286.0
HKD2_k127_10123216_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000000000000000000007799 95.0
HKD2_k127_10123216_3 MlaD protein K02067 - - 0.00000000000000000002141 102.0
HKD2_k127_10123216_4 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.00000000002238 65.0
HKD2_k127_10123216_5 ABC-type transport auxiliary lipoprotein component K09857 - - 0.0004357 50.0
HKD2_k127_1020427_0 metallopeptidase activity K03568 - - 9.81e-205 645.0
HKD2_k127_1020427_1 Ribosomal protein S1-like RNA-binding domain K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 531.0
HKD2_k127_1020427_2 metallopeptidase activity K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 441.0
HKD2_k127_1020427_3 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000001784 231.0
HKD2_k127_1020427_4 protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000000000000000000000000000000000001999 177.0
HKD2_k127_1020427_5 intermediate-associated protein 30 - - - 0.00000000000000000000000000000000000000002244 158.0
HKD2_k127_1020427_6 protein conserved in bacteria - - - 0.000000000000000000000000000000000000004729 150.0
HKD2_k127_1020427_7 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000005617 141.0
HKD2_k127_1020427_8 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000002448 132.0
HKD2_k127_1020427_9 COG0023 Translation initiation factor 1 (eIF-1 SUI1) and related K03113 - - 0.0000000000000000000201 97.0
HKD2_k127_1042469_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005775 455.0
HKD2_k127_1042469_1 queuosine biosynthetic process K03470,K09765 - 1.17.99.6,3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000001084 223.0
HKD2_k127_1042469_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000004615 207.0
HKD2_k127_1042469_3 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000008267 165.0
HKD2_k127_1042469_4 Protein of unknown function (DUF2905) - - - 0.000000000000000000007266 93.0
HKD2_k127_1042469_5 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.0001665 45.0
HKD2_k127_1063453_0 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 6.361e-225 721.0
HKD2_k127_1063453_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 1.166e-200 641.0
HKD2_k127_1063453_10 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000007922 227.0
HKD2_k127_1063453_11 PFAM response regulator receiver K03413 - - 0.00000000000000000000000000000000000000000000000000001432 192.0
HKD2_k127_1063453_12 Bacterial regulatory protein, Fis family K02481 - - 0.00000000000000000000000001324 127.0
HKD2_k127_1063453_13 phosphorelay signal transduction system K19622 - - 0.0000000000002594 76.0
HKD2_k127_1063453_14 cheY-homologous receiver domain - - - 0.000000000006925 66.0
HKD2_k127_1063453_16 STAS domain - - - 0.0000000008037 64.0
HKD2_k127_1063453_17 CheD chemotactic sensory transduction K03411 GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896 3.5.1.44 0.0003688 44.0
HKD2_k127_1063453_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 525.0
HKD2_k127_1063453_3 Chemotaxis sensory transducer K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004693 491.0
HKD2_k127_1063453_4 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02481,K11384 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007637 448.0
HKD2_k127_1063453_5 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 344.0
HKD2_k127_1063453_6 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 324.0
HKD2_k127_1063453_7 Two component signalling adaptor domain K03408 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001702 245.0
HKD2_k127_1063453_8 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000334 231.0
HKD2_k127_1063453_9 Methyl-accepting chemotaxis protein (MCP) signalling domain - - - 0.00000000000000000000000000000000000000000000000000000000007066 226.0
HKD2_k127_109899_0 Family 5 K02035,K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004059 375.0
HKD2_k127_109899_1 translation release factor activity K03265 GO:0001666,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0008150,GO:0009628,GO:0016020,GO:0030312,GO:0036293,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070482,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 316.0
HKD2_k127_109899_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005799 274.0
HKD2_k127_109899_3 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000001497 228.0
HKD2_k127_109899_4 - - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000006622 181.0
HKD2_k127_109899_5 Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000001312 178.0
HKD2_k127_109899_6 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000000000000000005227 137.0
HKD2_k127_109899_7 Haloacid dehalogenase domain protein hydrolase - - - 0.0000002114 52.0
HKD2_k127_1127538_0 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 566.0
HKD2_k127_1127538_1 AMP-binding enzyme C-terminal domain K05939 - 2.3.1.40,6.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 567.0
HKD2_k127_1127538_2 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 432.0
HKD2_k127_1127538_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000002409 246.0
HKD2_k127_1127538_4 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000000000000004132 170.0
HKD2_k127_1153510_0 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 359.0
HKD2_k127_1153510_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 327.0
HKD2_k127_1153510_10 PFAM CheW domain protein K03408 - - 0.00000000000000000000009969 106.0
HKD2_k127_1153510_2 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000838 295.0
HKD2_k127_1153510_3 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 311.0
HKD2_k127_1153510_4 Pfam:Arch_ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000811 283.0
HKD2_k127_1153510_5 HEAT repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007865 270.0
HKD2_k127_1153510_6 Response regulator receiver domain K03413 - - 0.00000000000000000000000000000000000000000001386 164.0
HKD2_k127_1153510_7 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000001418 171.0
HKD2_k127_1153510_8 PFAM CheW-like domain K03408 - - 0.000000000000000000000000000001399 127.0
HKD2_k127_1153510_9 chemotaxis protein K03407 - 2.7.13.3 0.0000000000000000000000004427 108.0
HKD2_k127_1155505_0 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008025 387.0
HKD2_k127_1155505_1 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 374.0
HKD2_k127_1155505_2 PFAM ATP-binding region, ATPase domain protein K04757 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000006109 196.0
HKD2_k127_1155505_3 PFAM Sulfate transporter antisigma-factor antagonist STAS K04749 - - 0.000000000000000000000000000000000000000000004851 165.0
HKD2_k127_1155505_4 Domain of unknown function (DUF4124) - - - 0.00000000000000000000000000000003491 132.0
HKD2_k127_1216594_0 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007144 576.0
HKD2_k127_1216594_1 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 456.0
HKD2_k127_1216594_2 Belongs to the MEMO1 family K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009858 276.0
HKD2_k127_1216594_3 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000009455 151.0
HKD2_k127_1216594_4 transcriptional regulator containing an HTH domain fused to a Zn-ribbon K07743 - - 0.000000000000000000000000000006668 122.0
HKD2_k127_1216594_5 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000000000001378 114.0
HKD2_k127_1216594_6 Binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000496 98.0
HKD2_k127_1216594_7 phosphoglucosamine mutase activity K01835,K01840 - 5.4.2.2,5.4.2.8 0.0000000000006144 69.0
HKD2_k127_1297650_0 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001764 257.0
HKD2_k127_1297650_1 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001325 250.0
HKD2_k127_1297650_2 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000004843 189.0
HKD2_k127_1297650_3 Haemolysin-type calcium-binding repeat (2 copies) - - - 0.0000000000000000000000000000000000000000000005752 179.0
HKD2_k127_1297650_4 LysM domain K01449,K19223 - 3.5.1.28 0.00000000000000004798 87.0
HKD2_k127_1297650_5 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0001924 46.0
HKD2_k127_1328371_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 1.947e-302 934.0
HKD2_k127_1328371_1 Class III cytochrome C family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 486.0
HKD2_k127_1328371_2 Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007718 392.0
HKD2_k127_1328371_3 PFAM glycosyl transferase, family 9 K02841 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003722 350.0
HKD2_k127_1328371_4 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005347 282.0
HKD2_k127_1328371_5 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001809 259.0
HKD2_k127_1328371_6 ACT domain K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000002929 255.0
HKD2_k127_1328371_7 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000005824 179.0
HKD2_k127_1334601_0 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 598.0
HKD2_k127_1334601_1 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005471 493.0
HKD2_k127_1334601_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000001957 246.0
HKD2_k127_1334601_3 ABC transporter K09691 - - 0.000000000000000000000000000000000000000000000000000000000000001495 226.0
HKD2_k127_1334601_4 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000001171 174.0
HKD2_k127_1334601_5 PFAM ABC-2 type transporter K09690 - - 0.000000000000000000000000000000000000169 152.0
HKD2_k127_1345891_0 PFAM Glycosyl transferases group 1 K13057 - 2.4.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000721 611.0
HKD2_k127_1345891_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002638 259.0
HKD2_k127_1345891_2 alpha amylase, catalytic K01236 - 3.2.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000001253 246.0
HKD2_k127_1345894_0 PFAM Glycosyl transferases group 1 K13057 - 2.4.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006628 600.0
HKD2_k127_1345894_1 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002963 253.0
HKD2_k127_1345894_2 glycoside hydrolase, family 13 domain protein K01236 - 3.2.1.141 0.0000000008907 63.0
HKD2_k127_1347322_0 PFAM ATP-binding region ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004303 412.0
HKD2_k127_1355263_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 548.0
HKD2_k127_1355263_1 arylsulfatase activity - - - 0.0000005263 61.0
HKD2_k127_1361685_0 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 601.0
HKD2_k127_1361685_1 Putative RNA methylase family UPF0020 K07444,K12297 - 2.1.1.173,2.1.1.264 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004844 483.0
HKD2_k127_1361685_2 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.00000000000000000000000000000000000000000000000000000000006175 209.0
HKD2_k127_1361685_3 membrane protein (DUF2207) - - - 0.0000000002295 64.0
HKD2_k127_1372395_0 PFAM natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005134 522.0
HKD2_k127_1372395_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 520.0
HKD2_k127_1372395_2 MgtE intracellular N domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 380.0
HKD2_k127_1372395_3 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000001433 236.0
HKD2_k127_1372896_0 Transglutaminase-like - - - 8.208e-239 767.0
HKD2_k127_1452829_0 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 9.136e-258 807.0
HKD2_k127_1452829_1 SMART AAA ATPase K02450 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 554.0
HKD2_k127_1452829_10 PEP-CTERM motif - - - 0.000000000000000000001048 106.0
HKD2_k127_1452829_11 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000002272 77.0
HKD2_k127_1452829_12 Type II secretion system protein B K02451 - - 0.00000000000000438 86.0
HKD2_k127_1452829_13 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000002478 65.0
HKD2_k127_1452829_2 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 453.0
HKD2_k127_1452829_3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 373.0
HKD2_k127_1452829_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004204 366.0
HKD2_k127_1452829_5 PFAM flavin reductase domain protein FMN-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000004375 228.0
HKD2_k127_1452829_6 Cyclophilin-like K09143 - - 0.00000000000000000000000000000000000000000000002192 173.0
HKD2_k127_1452829_7 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000687 128.0
HKD2_k127_1452829_8 - - - - 0.00000000000000000000000003128 114.0
HKD2_k127_1452829_9 SMART RNP-1 like RNA-binding protein - - - 0.000000000000000000000002444 106.0
HKD2_k127_1466210_0 carbon starvation protein CstA K06200 - - 3.936e-226 707.0
HKD2_k127_1466210_1 Hit family K19710 - 2.7.7.53 0.0000000000000000000000000000000000000000000000000000000000005987 214.0
HKD2_k127_1466210_2 SurA N-terminal domain K03771 - 5.2.1.8 0.0000000000000000000009672 106.0
HKD2_k127_1466210_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0007097 53.0
HKD2_k127_1476047_0 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 317.0
HKD2_k127_1476047_1 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 301.0
HKD2_k127_1476047_2 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001141 276.0
HKD2_k127_1476047_3 - - - - 0.00000000000000000000000000000002087 132.0
HKD2_k127_1476047_4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000007995 106.0
HKD2_k127_1482965_0 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003988 439.0
HKD2_k127_1482965_1 Chemotaxis sensory transducer K03406 - - 0.0000000001147 67.0
HKD2_k127_1482965_2 PFAM Integrase - - - 0.000008339 49.0
HKD2_k127_1500040_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 572.0
HKD2_k127_1500040_1 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 421.0
HKD2_k127_1500040_2 one-carbon metabolic process K00194,K00198 - 1.2.7.4,2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008374 395.0
HKD2_k127_1500040_3 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 385.0
HKD2_k127_1500040_4 acetyl-CoA catabolic process K00197 - 2.1.1.245 0.0000000000000000000000000000000000000003891 151.0
HKD2_k127_1500040_5 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000001281 135.0
HKD2_k127_151618_0 Acyl-CoA synthetase (NDP forming) K09181 - - 3.324e-241 764.0
HKD2_k127_151618_1 inositol-3-phosphate synthase activity K01858 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009064 536.0
HKD2_k127_151618_10 DNA-binding transcription factor activity - - - 0.00000000000001242 79.0
HKD2_k127_151618_12 domain protein - - - 0.000008878 51.0
HKD2_k127_151618_13 - - - - 0.00002068 48.0
HKD2_k127_151618_2 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 382.0
HKD2_k127_151618_3 Acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000033 352.0
HKD2_k127_151618_4 DRTGG domain protein K06873 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006067 328.0
HKD2_k127_151618_5 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000000000000000001015 227.0
HKD2_k127_151618_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000000001047 191.0
HKD2_k127_151618_7 PFAM Polynucleotide adenylyltransferase region K00970,K00974 - 2.7.7.19,2.7.7.72 0.0000000000000000000000000002849 128.0
HKD2_k127_151618_8 AMP binding - - - 0.00000000000000000001656 96.0
HKD2_k127_151618_9 Psort location Cytoplasmic, score 8.87 - - - 0.00000000000000001334 87.0
HKD2_k127_1521670_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009203 341.0
HKD2_k127_1521670_1 TIGRFAM phosphate ABC transporter, inner membrane subunit PstA K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003105 314.0
HKD2_k127_1521670_2 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003372 254.0
HKD2_k127_1521670_3 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000001578 147.0
HKD2_k127_1534996_0 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 5.398e-218 685.0
HKD2_k127_1534996_1 lipoprotein localization to outer membrane K02004,K09808 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0089705,GO:0098796,GO:0098797,GO:1990778 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 381.0
HKD2_k127_1534996_2 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002577 257.0
HKD2_k127_153894_0 Na dependent nucleoside transporter K03317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 490.0
HKD2_k127_153894_1 peptidyl-lysine modification to peptidyl-hypusine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 362.0
HKD2_k127_153894_2 Ferredoxin-fold anticodon binding domain K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000001207 112.0
HKD2_k127_1551507_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 - 1.12.99.6 3.499e-212 670.0
HKD2_k127_1551507_1 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 5.942e-209 660.0
HKD2_k127_1551507_10 hydrogenase maturation protease K03605 - - 0.00000000000000000000000000000000000000000000001843 177.0
HKD2_k127_1551507_11 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.00000000000000000000000000001114 124.0
HKD2_k127_1551507_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K16950 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007143 470.0
HKD2_k127_1551507_3 coenzyme F420 hydrogenase activity K14128 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 401.0
HKD2_k127_1551507_4 Nickel-dependent hydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 381.0
HKD2_k127_1551507_5 Oxidoreductase NAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 372.0
HKD2_k127_1551507_6 PFAM NADH ubiquinone oxidoreductase, 20 Kd subunit K06282 - 1.12.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005902 327.0
HKD2_k127_1551507_7 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000002619 266.0
HKD2_k127_1551507_8 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000006131 264.0
HKD2_k127_1551507_9 Phage integrase, N-terminal SAM-like domain K03733 - - 0.000000000000000000000000000000000000000000000000000001003 195.0
HKD2_k127_1574541_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 518.0
HKD2_k127_1574541_1 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 501.0
HKD2_k127_1574541_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000109 249.0
HKD2_k127_1574541_3 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000009705 183.0
HKD2_k127_1574541_4 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family K01406,K13276,K20276 - 3.4.24.40 0.000000000000000000000000000000000000002734 168.0
HKD2_k127_1574541_5 zinc-ribbon domain - - - 0.0000000000000000005062 92.0
HKD2_k127_1574541_6 Outer Membrane Lipoprotein - GO:0008150,GO:0043900,GO:0050789,GO:0050794,GO:0065007,GO:1900190 - 0.000000000000000005796 86.0
HKD2_k127_1581243_0 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000388 540.0
HKD2_k127_1581243_1 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009388 420.0
HKD2_k127_1581243_2 Male sterility protein K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 417.0
HKD2_k127_1581243_3 Belongs to the pseudouridine synthase RsuA family K06178,K06181,K06182 - 5.4.99.20,5.4.99.21,5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000528 295.0
HKD2_k127_1581243_4 deaminase K01493 - 3.5.4.12 0.000007049 49.0
HKD2_k127_1608494_0 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 399.0
HKD2_k127_1608494_1 Virulence factor BrkB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 295.0
HKD2_k127_1608494_2 retrograde transport, endosome to Golgi K07095 - - 0.000000000000000000000000000000000000000000000001023 190.0
HKD2_k127_1608494_3 Hep Hag repeat protein - - - 0.000001627 52.0
HKD2_k127_1610073_0 Belongs to the helicase family. UvrD subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 589.0
HKD2_k127_1610073_1 Putative zinc- or iron-chelating domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002172 264.0
HKD2_k127_1610073_2 Domain of unknown function (DUF3842) - - - 0.0000000000000000000000000000000003669 133.0
HKD2_k127_1610073_3 - - - - 0.00000000000000000000000000009708 123.0
HKD2_k127_1610073_4 Predicted RNA-binding protein - - - 0.0000000000000000000001206 98.0
HKD2_k127_1629461_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002896 502.0
HKD2_k127_1629461_1 GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 382.0
HKD2_k127_1629461_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 372.0
HKD2_k127_1629461_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 359.0
HKD2_k127_1629461_4 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000003417 216.0
HKD2_k127_1641891_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000583 376.0
HKD2_k127_1641891_1 Transposase DDE domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 344.0
HKD2_k127_1641891_2 - - - - 0.0000000000000001869 81.0
HKD2_k127_1641891_3 PFAM Tetratricopeptide repeat - - - 0.00000000006247 66.0
HKD2_k127_1670360_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005391 576.0
HKD2_k127_1670360_1 Class III cytochrome C family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001693 516.0
HKD2_k127_1670360_10 hydrogenase maturation protease K03605 - - 0.000000000000004102 78.0
HKD2_k127_1670360_2 PFAM Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004404 508.0
HKD2_k127_1670360_3 Involved in the tonB-independent uptake of proteins K03641 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 472.0
HKD2_k127_1670360_4 4 iron, 4 sulfur cluster binding K00124 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 388.0
HKD2_k127_1670360_5 nitrate reductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004003 275.0
HKD2_k127_1670360_6 Dinitrogenase iron-molybdenum cofactor - - - 0.0000000000000000000000000000000000000000001452 162.0
HKD2_k127_1670360_7 CGGC - - - 0.00000000000000000000000000000000000002478 147.0
HKD2_k127_1670360_8 Belongs to the UPF0251 family - - - 0.00000000000000000000000002848 111.0
HKD2_k127_1670360_9 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.000000000000000000002139 94.0
HKD2_k127_1702275_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 586.0
HKD2_k127_1702275_1 B3/4 domain K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 531.0
HKD2_k127_1702275_2 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 365.0
HKD2_k127_1702275_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000000000000000000000000004293 234.0
HKD2_k127_1702275_4 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000000000002177 223.0
HKD2_k127_1702275_5 Belongs to the ompA family K03286 - - 0.000000000000000000000000000000000000000000000000000004026 208.0
HKD2_k127_1702275_6 Dihydroorotate dehydrogenase electron transfer subunit K02823 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016645,GO:0016646,GO:0042602,GO:0052875,GO:0055114 - 0.000000000000000000000000000000000000000000452 167.0
HKD2_k127_174089_0 Belongs to the peptidase S16 family K01338,K04076 - 3.4.21.53 0.0 1051.0
HKD2_k127_174089_1 PFAM lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004244 285.0
HKD2_k127_174106_0 PFAM AMP-dependent synthetase and ligase K01908 - 6.2.1.17 0.0 1078.0
HKD2_k127_174106_1 Belongs to the peptidase S16 family - - - 9.219e-228 730.0
HKD2_k127_174106_10 Aldo/keto reductase family - - - 0.000000000000000000000000000000005328 129.0
HKD2_k127_174106_11 tetratricopeptide repeat - - - 0.000006351 59.0
HKD2_k127_174106_2 4 iron, 4 sulfur cluster binding K07139 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000326 416.0
HKD2_k127_174106_3 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006676 306.0
HKD2_k127_174106_4 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 285.0
HKD2_k127_174106_5 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000000000000000002315 199.0
HKD2_k127_174106_6 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000000001795 185.0
HKD2_k127_174106_7 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000009891 166.0
HKD2_k127_174106_8 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000002366 159.0
HKD2_k127_174106_9 Domain of unknown function (DUF4388) - - - 0.00000000000000000000000000000000000005411 158.0
HKD2_k127_1745376_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 3.801e-198 631.0
HKD2_k127_1745376_1 Ftsk_gamma K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 384.0
HKD2_k127_1745376_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP) K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 301.0
HKD2_k127_1745376_3 PFAM Cytidine and deoxycytidylate deaminase zinc-binding region K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000001343 174.0
HKD2_k127_1745376_4 Protein of unknown function (DUF3187) - - - 0.0000000000000000000001566 109.0
HKD2_k127_1789870_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008317 356.0
HKD2_k127_1789870_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 331.0
HKD2_k127_1789870_10 Mediates influx of magnesium ions K03284 - - 0.00000000000003682 72.0
HKD2_k127_1789870_11 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03116,K03117 - - 0.0000000000008714 73.0
HKD2_k127_1789870_2 PFAM VacJ family lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009707 258.0
HKD2_k127_1789870_3 HEAT repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000003228 243.0
HKD2_k127_1789870_4 MlaC protein K07323 - - 0.0000000000000000000000000000000000000000000000000000000000002753 217.0
HKD2_k127_1789870_6 PFAM Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.0000000000000000000000000000000000000000000000005978 178.0
HKD2_k127_1789870_7 - - - - 0.0000000000000000000000000000000000000004214 154.0
HKD2_k127_1789870_8 PFAM Glutaredoxin K06191 - - 0.0000000000000000000000000001194 117.0
HKD2_k127_1795022_0 fatty acid beta-oxidation using acyl-CoA dehydrogenase K03522,K22432 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009055,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0019395,GO:0019752,GO:0022900,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.3.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006753 507.0
HKD2_k127_1795022_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003573 430.0
HKD2_k127_1795022_2 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002515 342.0
HKD2_k127_1795022_3 Electron transfer flavoprotein K03521 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016020,GO:0016491,GO:0022900,GO:0030312,GO:0040007,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 324.0
HKD2_k127_1795022_4 COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - 0.000000000000000000000000000000000000000000000000000000001078 215.0
HKD2_k127_1799275_0 PD-(D/E)XK nuclease superfamily - - - 2.435e-246 795.0
HKD2_k127_1799275_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005499 275.0
HKD2_k127_1799275_2 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000001107 235.0
HKD2_k127_1799275_3 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000644 160.0
HKD2_k127_1799275_4 Belongs to the helicase family. UvrD subfamily - - - 0.00000000000000000000000000000000000000003844 161.0
HKD2_k127_1799275_5 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000006326 138.0
HKD2_k127_1827496_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004498 557.0
HKD2_k127_1827496_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 479.0
HKD2_k127_1827496_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000006094 173.0
HKD2_k127_1827496_3 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000002238 157.0
HKD2_k127_1827496_4 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000000000000009446 85.0
HKD2_k127_1828043_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 298.0
HKD2_k127_1828043_1 - - - - 0.0001355 51.0
HKD2_k127_1913881_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 443.0
HKD2_k127_1913881_1 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002998 319.0
HKD2_k127_1913881_2 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000333 244.0
HKD2_k127_1913881_3 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000002792 198.0
HKD2_k127_1913881_4 PFAM Uncharacterised protein family UPF0079, ATPase K06925 - - 0.0000000000000000000000000000001099 131.0
HKD2_k127_1913881_5 PFAM Type II secretion system protein E K02652 - - 0.000000000000000000007862 102.0
HKD2_k127_1913881_6 twitching motility protein K02669 - - 0.00000000005349 72.0
HKD2_k127_1952437_0 ABC transporter transmembrane region K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000829 510.0
HKD2_k127_1952437_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009396 427.0
HKD2_k127_1952437_10 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000003663 137.0
HKD2_k127_1952437_11 kinase activity - - - 0.000000000000000000000000000002176 131.0
HKD2_k127_1952437_13 COGs COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferase of PMT family - - - 0.0005513 51.0
HKD2_k127_1952437_2 Phosphomethylpyrimidine kinase K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 351.0
HKD2_k127_1952437_3 Histidine biosynthesis protein K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004749 293.0
HKD2_k127_1952437_4 Thiamine biosynthesis protein (ThiI) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004806 282.0
HKD2_k127_1952437_5 Catalyzes the synthesis of activated sulfate K00860 - 2.7.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000948 270.0
HKD2_k127_1952437_6 Protein of unknown function (DUF3108) - - - 0.00000000000000000000000000000000000000000000000000000000000415 216.0
HKD2_k127_1952437_7 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000002086 212.0
HKD2_k127_1952437_8 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000000000000000000006871 197.0
HKD2_k127_1952437_9 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000005417 190.0
HKD2_k127_200472_0 PFAM Radical SAM domain protein K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 599.0
HKD2_k127_200472_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006664 604.0
HKD2_k127_200472_10 phosphatase homologous to the C-terminal domain of histone macroH2A1 K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000006691 229.0
HKD2_k127_200472_11 Part of a membrane complex involved in electron transport K03613 - - 0.00000000000000000000000000000000000000000000000000000000000000003265 230.0
HKD2_k127_200472_12 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000001022 183.0
HKD2_k127_200472_13 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000001444 126.0
HKD2_k127_200472_14 Part of a membrane complex involved in electron transport K03612 - - 0.000000000000000000000000003336 119.0
HKD2_k127_200472_15 GIY-YIG catalytic domain K07461 - - 0.0000000000000000000004941 98.0
HKD2_k127_200472_2 Part of a membrane complex involved in electron transport K03615 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 499.0
HKD2_k127_200472_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004333 495.0
HKD2_k127_200472_4 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 434.0
HKD2_k127_200472_5 Part of a membrane complex involved in electron transport K03614 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002037 370.0
HKD2_k127_200472_6 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 317.0
HKD2_k127_200472_7 electron transport complex, RnfABCDGE type, B subunit K03616 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 317.0
HKD2_k127_200472_8 Part of a membrane complex involved in electron transport K03617 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003492 245.0
HKD2_k127_200472_9 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000006416 241.0
HKD2_k127_2013648_0 PFAM NAD-dependent epimerase dehydratase K08678 - 4.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 369.0
HKD2_k127_2013648_1 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000005731 248.0
HKD2_k127_2013648_2 DNA-binding transcription factor activity K18996 - - 0.000000000000000000000000000004424 123.0
HKD2_k127_202027_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1221.0
HKD2_k127_202027_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1056.0
HKD2_k127_202027_2 Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP- dependent clade X sub-subfamily K00850 - 2.7.1.11 8.752e-194 613.0
HKD2_k127_202027_3 Fructose-bisphosphate aldolase class-II K01624 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005547 567.0
HKD2_k127_202027_4 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 331.0
HKD2_k127_202027_5 Belongs to the GPI family K01810 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001466 305.0
HKD2_k127_2075863_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007159 385.0
HKD2_k127_2075863_1 - K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004267 329.0
HKD2_k127_2075863_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005798 262.0
HKD2_k127_2075863_3 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.000000000000000000000000000000000002603 147.0
HKD2_k127_2082435_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 7.228e-270 843.0
HKD2_k127_2082435_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 4.317e-252 787.0
HKD2_k127_2089628_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004448 403.0
HKD2_k127_2089628_1 4Fe-4S ferredoxin iron-sulfur binding domain protein K07138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 362.0
HKD2_k127_2089628_2 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000002677 139.0
HKD2_k127_2149499_0 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.000000000000000000000000000000000000000000007227 172.0
HKD2_k127_2149499_1 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.000000000000000000000000000000000000000006924 159.0
HKD2_k127_2149499_2 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.000000000001482 70.0
HKD2_k127_2166123_0 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336,K05299 - 1.17.1.10,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004832 503.0
HKD2_k127_2166123_1 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004275 310.0
HKD2_k127_2166123_2 Cytochrome C biogenesis protein transmembrane region K06196 - - 0.000000000000000000000000000000000000000000000000000000000000002023 225.0
HKD2_k127_2166123_3 FmdE, Molybdenum formylmethanofuran dehydrogenase operon K11261 - 1.2.7.12 0.00000000000000000000000000000000000003051 145.0
HKD2_k127_2166123_4 LuxR family transcriptional regulator - - - 0.000000004202 59.0
HKD2_k127_2193163_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 2146.0
HKD2_k127_2193163_1 RNA polymerase beta subunit external 1 domain K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1602.0
HKD2_k127_2193163_10 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000003341 140.0
HKD2_k127_2193163_11 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.0000000000000000000000000000000007799 134.0
HKD2_k127_2193163_12 Thioredoxin domain - - - 0.000000000000000000000000000000002639 133.0
HKD2_k127_2193163_13 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000006905 127.0
HKD2_k127_2193163_14 Thioredoxin domain - - - 0.0000000000000000002382 89.0
HKD2_k127_2193163_15 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000002587 87.0
HKD2_k127_2193163_16 structural constituent of ribosome K02913 - - 0.00000000000000001983 82.0
HKD2_k127_2193163_17 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.00000000000007158 74.0
HKD2_k127_2193163_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 6.435e-249 779.0
HKD2_k127_2193163_3 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 413.0
HKD2_k127_2193163_4 PFAM DAHP synthetase I KDSA K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008824 364.0
HKD2_k127_2193163_5 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005648 342.0
HKD2_k127_2193163_6 Pyridine nucleotide-disulphide oxidoreductase K03387 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000867 271.0
HKD2_k127_2193163_7 Participates in transcription elongation, termination and antitermination K02601 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009784 247.0
HKD2_k127_2193163_8 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000000003287 213.0
HKD2_k127_2193163_9 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000000000000000000000008643 200.0
HKD2_k127_2258669_0 Type II and III secretion system protein K02453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 488.0
HKD2_k127_2320264_0 Beta-ketoacyl synthase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 369.0
HKD2_k127_2320264_1 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 283.0
HKD2_k127_2320264_2 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007924 273.0
HKD2_k127_2320264_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000007027 181.0
HKD2_k127_2320264_4 3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein) K02372 - 4.2.1.59 0.0000000000000000000000000000000000003799 144.0
HKD2_k127_2320264_5 Putative methyltransferase - - - 0.000000000000000000000702 109.0
HKD2_k127_2351526_0 ABC-type multidrug transport system ATPase and permease K06147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007646 473.0
HKD2_k127_2370017_0 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002042 451.0
HKD2_k127_2370017_1 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 445.0
HKD2_k127_2370017_10 Enoyl-CoA hydratase/isomerase K13767 - 4.2.1.17 0.00000000000000000000000000000000000000000000004592 179.0
HKD2_k127_2370017_11 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000004561 170.0
HKD2_k127_2370017_12 Enoyl-CoA hydratase K16425 GO:0003674,GO:0003824,GO:0004300,GO:0016829,GO:0016835,GO:0016836 - 0.0000000000000000000000000000000000565 143.0
HKD2_k127_2370017_13 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000001074 125.0
HKD2_k127_2370017_14 Phosphopantetheine attachment site - - - 0.0000000000000000000000000002161 117.0
HKD2_k127_2370017_15 Malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000002093 123.0
HKD2_k127_2370017_16 ABC-2 family transporter protein K01992 - - 0.0000000001036 71.0
HKD2_k127_2370017_17 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000004748 63.0
HKD2_k127_2370017_2 synthase K16167,K16424 GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747 2.3.1.246 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007769 345.0
HKD2_k127_2370017_3 PFAM metallopeptidase family M24 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 310.0
HKD2_k127_2370017_4 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 301.0
HKD2_k127_2370017_5 ABC transporter K01990,K11050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001616 289.0
HKD2_k127_2370017_6 LysE type translocator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001329 254.0
HKD2_k127_2370017_7 PFAM O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000001402 243.0
HKD2_k127_2370017_8 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III - - - 0.0000000000000000000000000000000000000000000000000000000000000002446 226.0
HKD2_k127_2370017_9 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000009762 180.0
HKD2_k127_2410594_0 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 7.747e-217 695.0
HKD2_k127_2410594_1 MgsA AAA+ ATPase C terminal K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002726 581.0
HKD2_k127_2410594_2 Pas domain s-box - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 385.0
HKD2_k127_2410594_3 Histidine kinase K07675 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003888 285.0
HKD2_k127_2410594_5 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000192 221.0
HKD2_k127_2410594_6 Drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000198 113.0
HKD2_k127_2499366_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01006 - 2.7.9.1 0.0 1225.0
HKD2_k127_2528392_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 - 1.12.99.6 3.875e-213 673.0
HKD2_k127_2528392_1 PFAM NADH ubiquinone oxidoreductase, 20 Kd subunit K06282 - 1.12.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 358.0
HKD2_k127_2528392_2 hydrogenase maturation protease K03605 - - 0.0000000000000000000000005322 110.0
HKD2_k127_2546823_0 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826,K02619 - 2.6.1.42,4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000056 279.0
HKD2_k127_2546823_1 Oligopeptidase F K08602 - - 0.000000000000000000000000000000000000000000000000000000000000000000001967 258.0
HKD2_k127_2546823_2 Domain of unknown function (DUF296) - - - 0.00000000000000000000000000000000000000000000000000000002982 200.0
HKD2_k127_2546823_3 - - - - 0.000000000000000000000000000000000000000000000001684 180.0
HKD2_k127_2546823_4 Lipoate-protein ligase K03800 GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 0.000000000000000000000000000000000000000000000008766 181.0
HKD2_k127_2546823_5 Subtilase family - - - 0.0000000000000000000000000000000005351 149.0
HKD2_k127_2546823_6 Belongs to the ompA family K03286 - - 0.0000000000000000000000001479 114.0
HKD2_k127_2546823_7 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.000000000006101 72.0
HKD2_k127_2559232_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 346.0
HKD2_k127_2559232_1 Histidine kinase K07641,K07642,K07711 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 299.0
HKD2_k127_2559232_2 PFAM response regulator receiver K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001158 253.0
HKD2_k127_2574706_0 DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 609.0
HKD2_k127_2574706_1 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001745 246.0
HKD2_k127_2574706_2 Glycosyltransferase like family - - - 0.00000000000000000000000000000000000000000000000000000000002615 215.0
HKD2_k127_2574706_3 Nucleoside-diphosphate-sugar epimerases - - - 0.00000000000000000000000000000000000000000004172 171.0
HKD2_k127_2574706_4 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000000000000321 140.0
HKD2_k127_2574706_5 Glycosyltransferase like family 2 - - - 0.00000000000000000000009752 108.0
HKD2_k127_2574706_6 Glycosyltransferase like family 2 K07011,K20444 - - 0.00000000000000000001134 108.0
HKD2_k127_2574706_7 - - - - 0.000000000000006001 75.0
HKD2_k127_2574706_8 Methyltransferase domain - - - 0.000000000001653 81.0
HKD2_k127_2582279_0 domain, Protein - - - 2.205e-225 709.0
HKD2_k127_2582279_1 M42 glutamyl aminopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 428.0
HKD2_k127_2582279_2 PFAM Isochorismatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 287.0
HKD2_k127_2582279_3 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K01883,K02533,K08281,K15396 - 2.1.1.200,3.5.1.19,6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000007623 241.0
HKD2_k127_25836_0 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004225 374.0
HKD2_k127_25836_1 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000139 166.0
HKD2_k127_2584939_0 DALR_2 K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003169 572.0
HKD2_k127_2584939_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008099 548.0
HKD2_k127_2584939_2 Large family of predicted nucleotide-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 311.0
HKD2_k127_2584939_3 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000000009362 230.0
HKD2_k127_2584939_4 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.0000000000000000000000000000000000000000000000000000000000001624 219.0
HKD2_k127_2584939_5 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000000000000000000000000000000000000000000001906 203.0
HKD2_k127_2584939_6 deoxyhypusine monooxygenase activity K05384,K05386 - - 0.00000000000000000000001765 105.0
HKD2_k127_2584939_7 - - - - 0.000001016 57.0
HKD2_k127_2584939_8 Evidence 5 No homology to any previously reported sequences - - - 0.00000111 51.0
HKD2_k127_2589832_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 2.948e-230 737.0
HKD2_k127_2589832_1 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.0000000000000000000000000000000000000000000000000000000000000009097 228.0
HKD2_k127_2589832_2 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000000000000000000000003879 206.0
HKD2_k127_2589832_3 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006082,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0051186,GO:0051188,GO:0070566,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.00000000000000000000000000000000000000000000000000004498 192.0
HKD2_k127_2589832_4 Methyltransferase K08316 - 2.1.1.171 0.0000000000000000000000000000000000000001421 158.0
HKD2_k127_2589832_5 molybdopterin synthase activity K03635,K03752 - 2.7.7.77,2.8.1.12 0.0000000000000000000000000000000000000001811 153.0
HKD2_k127_2589832_6 DsrE/DsrF-like family - - - 0.00000000000000000000000000000000000001341 150.0
HKD2_k127_2589832_7 Belongs to the UPF0146 family K09713 - - 0.00000000000000000000000001782 113.0
HKD2_k127_2595284_0 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000527 291.0
HKD2_k127_2595284_1 PFAM Glycosyl hydrolase family 3 N terminal domain K01207,K05349 - 3.2.1.21,3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000008543 251.0
HKD2_k127_2595284_2 PFAM Phosphoglycerate mutase K02226 - 3.1.3.73 0.000000000000000000000000000000000000000000000000000000007526 204.0
HKD2_k127_2595284_3 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000003337 66.0
HKD2_k127_2595284_4 PGAP1-like protein - - - 0.00000615 57.0
HKD2_k127_2601162_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001869 277.0
HKD2_k127_2601162_1 PFAM Glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009129 265.0
HKD2_k127_2601162_2 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000001865 182.0
HKD2_k127_2601162_3 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000001342 148.0
HKD2_k127_2601162_4 PFAM Glycosyl transferase family 2 K20444 - - 0.00000000000000000005144 93.0
HKD2_k127_2601162_5 Protein of unknown function (DUF559) - - - 0.0001172 44.0
HKD2_k127_2630578_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K00174 - 1.2.7.11,1.2.7.3 1.312e-216 686.0
HKD2_k127_2630578_1 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 366.0
HKD2_k127_2630578_10 radical SAM domain protein - - - 0.00000006091 59.0
HKD2_k127_2630578_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002655 246.0
HKD2_k127_2630578_3 Signal transduction histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000001581 244.0
HKD2_k127_2630578_4 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000006522 211.0
HKD2_k127_2630578_5 radical SAM K06871 - - 0.0000000000000000000000000000000000000000000001591 182.0
HKD2_k127_2630578_6 part of a sulfur-relay system - - - 0.00000000000000000000000000001148 121.0
HKD2_k127_2630578_7 electron transfer activity K05337,K17247 - - 0.0000000000000000000002829 97.0
HKD2_k127_2630578_8 Belongs to the Fur family K09825 - - 0.0000000000000000134 84.0
HKD2_k127_2630578_9 Rubrerythrin - - - 0.0000000002976 68.0
HKD2_k127_2638433_0 Dehydratase family K01687 - 4.2.1.9 2.131e-263 821.0
HKD2_k127_2638433_1 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007718 477.0
HKD2_k127_2638433_2 radical SAM domain protein K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008803 418.0
HKD2_k127_2638433_3 PFAM NAD dependent epimerase dehydratase family K07071 - - 0.0000000000000000000000000000000000000000000000000000001485 205.0
HKD2_k127_2638433_4 monooxygenase activity - - - 0.000000000000000000000000000000000000000000000003765 177.0
HKD2_k127_2638433_5 SRPBCC domain-containing protein - - - 0.000000000000000000000000000002049 127.0
HKD2_k127_2638433_7 Protein of unknown function (DUF465) K09794 - - 0.000000000000000001476 87.0
HKD2_k127_2638433_9 PFAM Methyltransferase - - - 0.000000001356 59.0
HKD2_k127_2653075_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007367 502.0
HKD2_k127_2653075_1 metal-dependent enzyme K09153 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 304.0
HKD2_k127_2653075_2 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006691 257.0
HKD2_k127_2653075_3 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537,K01539 - 3.6.3.8,3.6.3.9 0.0000000000000000000000000000000000000000000006786 169.0
HKD2_k127_2653075_4 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000000000000000143 143.0
HKD2_k127_2653075_5 - - - - 0.0000000000000000000000000000002013 130.0
HKD2_k127_2653075_6 Binds the 23S rRNA K02909 - - 0.00000000000000000000000005035 108.0
HKD2_k127_2653075_7 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000119 107.0
HKD2_k127_2653075_8 Belongs to the PdxA family K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.000000000001678 69.0
HKD2_k127_2659766_0 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000891 402.0
HKD2_k127_2659766_1 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007868 353.0
HKD2_k127_2659766_2 PFAM NUDIX hydrolase - - - 0.000000000000000000000000000000000000000000000000000006051 195.0
HKD2_k127_2659766_3 phosphatase activity K05967 - - 0.00000000000000000000000000000000000000006259 158.0
HKD2_k127_2659766_5 SMART Cold shock protein K03704 - - 0.0000000000000000000000000001297 117.0
HKD2_k127_2659766_6 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.00000000000000000000000001054 112.0
HKD2_k127_2659766_7 chitin catabolic process - - - 0.0002709 51.0
HKD2_k127_2753526_0 PFAM alpha amylase, catalytic K06044 - 5.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 348.0
HKD2_k127_2753526_1 ribonuclease BN - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004085 274.0
HKD2_k127_2753526_2 Alpha amylase, catalytic domain K06044 - 5.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000001168 257.0
HKD2_k127_2753526_3 Alpha amylase, catalytic domain K06044 - 5.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000006408 228.0
HKD2_k127_2753526_4 PFAM Glycosyl transferases group 1 K13057 - 2.4.1.245 0.00001098 48.0
HKD2_k127_2767216_0 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 382.0
HKD2_k127_2767216_1 Cobalt transport protein K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002658 267.0
HKD2_k127_2767216_2 wide pore channel activity K07267 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005247 252.0
HKD2_k127_2767216_3 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K16787 - - 0.0000000000000000000000000002719 118.0
HKD2_k127_2852724_0 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 557.0
HKD2_k127_2852724_1 HlyD family secretion protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 483.0
HKD2_k127_2852724_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 363.0
HKD2_k127_2852724_3 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001093 277.0
HKD2_k127_2852724_4 Redoxin K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000008386 235.0
HKD2_k127_2852724_5 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000407 184.0
HKD2_k127_2852724_6 Trypsin-like peptidase domain - - - 0.0000000000000000000000135 115.0
HKD2_k127_2852724_7 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000006484 77.0
HKD2_k127_2852724_8 Tetratricopeptide repeat - - - 0.0000000000001379 83.0
HKD2_k127_2852724_9 MacB-like periplasmic core domain K02004 - - 0.000000000003702 66.0
HKD2_k127_2869162_0 ABC transporter K06158 - - 5.725e-238 750.0
HKD2_k127_2869162_1 Elongator protein 3, MiaB family, Radical SAM - - - 4.659e-194 618.0
HKD2_k127_2869162_2 PFAM Major Facilitator Superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 510.0
HKD2_k127_2869162_3 Metallo-beta-lactamase superfamily K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 516.0
HKD2_k127_2869162_4 Alpha-tubulin suppressor and related RCC1 domain-containing proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008625 345.0
HKD2_k127_289736_0 Trypsin K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 433.0
HKD2_k127_289736_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002344 337.0
HKD2_k127_289736_2 Cysteine-rich domain - - - 0.0000000000000000000000000000000000000000000009704 169.0
HKD2_k127_289736_3 - - - - 0.0000000000000000000000000008173 123.0
HKD2_k127_2903388_0 Type II secretion system protein E K02652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001944 608.0
HKD2_k127_2903388_1 twitching motility protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 554.0
HKD2_k127_2903388_2 Type II secretion system (T2SS), protein F K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000881 371.0
HKD2_k127_2925253_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 7.116e-243 759.0
HKD2_k127_2925253_1 ACT domain K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006004 591.0
HKD2_k127_2925253_2 2Fe-2S iron-sulfur cluster binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000476 591.0
HKD2_k127_2925253_3 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007895 355.0
HKD2_k127_2925253_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000002939 245.0
HKD2_k127_2925253_5 diguanylate cyclase activity K02488 - 2.7.7.65 0.000000000000000000000000000000000001204 156.0
HKD2_k127_2925253_6 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000009225 57.0
HKD2_k127_294022_0 Aminotransferase class-III K01845 - 5.4.3.8 1.224e-202 638.0
HKD2_k127_294022_1 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 565.0
HKD2_k127_294022_10 RelA SpoT domain protein K07816 - 2.7.6.5 0.00000122 57.0
HKD2_k127_294022_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 370.0
HKD2_k127_294022_3 membrane K09133 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 339.0
HKD2_k127_294022_4 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000001296 227.0
HKD2_k127_294022_5 PFAM Archease protein family (DUF101 UPF0211) - - - 0.000000000000000000000000000000000008266 140.0
HKD2_k127_294022_6 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.000000000000000000000000000000001938 131.0
HKD2_k127_294022_8 response to copper ion - - - 0.00000000000000000000001034 112.0
HKD2_k127_294022_9 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.0000000002008 64.0
HKD2_k127_2972166_0 Sigma-54 interaction domain K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 397.0
HKD2_k127_2972166_1 ATPases associated with a variety of cellular activities K09689,K09691 - 3.6.3.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 305.0
HKD2_k127_2972166_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003703 256.0
HKD2_k127_2972166_3 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001696 241.0
HKD2_k127_2972166_4 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000006163 189.0
HKD2_k127_2972166_5 ABC-2 type transporter K01992,K09690,K09691,K09692 - - 0.000000000000000000000000000000000000000000009093 172.0
HKD2_k127_2972166_6 Glycosyl transferases group 1 - - - 0.000000000000000000000002803 115.0
HKD2_k127_2972166_7 PFAM Radical SAM - - - 0.000000000000000000000006895 115.0
HKD2_k127_2972166_8 Acetyltransferase (GNAT) domain - - - 0.0000000000000000001035 100.0
HKD2_k127_2992814_0 PFAM Iron-binding zinc finger CDGSH type - - - 0.00000000000000000000000000001016 119.0
HKD2_k127_2992814_1 Lipocalin-like domain - - - 0.000000000000000000001909 102.0
HKD2_k127_2992814_2 Subtilase family - - - 0.0000000000002422 83.0
HKD2_k127_2992814_3 - - - - 0.0000000001219 64.0
HKD2_k127_2996483_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007357 359.0
HKD2_k127_2996483_3 Binds directly to 16S ribosomal RNA K02968 - - 0.000000000000005674 78.0
HKD2_k127_2996483_4 DNA polymerase III, delta' subunit K02340 - 2.7.7.7 0.00000000000169 78.0
HKD2_k127_2998436_0 Leucyl-tRNA synthetase, Domain 2 K01869 - 6.1.1.4 1.928e-270 841.0
HKD2_k127_2998436_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 6.672e-196 618.0
HKD2_k127_2998436_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000344 406.0
HKD2_k127_2998436_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 371.0
HKD2_k127_2998436_4 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 357.0
HKD2_k127_2998436_5 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000000000263 198.0
HKD2_k127_2998436_6 SurA N-terminal domain K03770 - 5.2.1.8 0.0000000000000000000000000000000000000002263 157.0
HKD2_k127_2998436_7 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000000009149 139.0
HKD2_k127_2998436_8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016246,GO:0016441,GO:0016458,GO:0017148,GO:0019222,GO:0022607,GO:0022613,GO:0022618,GO:0030423,GO:0031047,GO:0031123,GO:0031124,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032269,GO:0032270,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0035194,GO:0040029,GO:0040033,GO:0043170,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045974,GO:0045975,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113 - 0.000000000000000000003286 95.0
HKD2_k127_2998436_9 PFAM NHL repeat - - - 0.00000005813 64.0
HKD2_k127_3037101_0 Transporter associated domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 474.0
HKD2_k127_3037101_1 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 387.0
HKD2_k127_3037101_2 PFAM Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 343.0
HKD2_k127_3037101_3 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 301.0
HKD2_k127_3037101_4 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.00000000000000000000000000000000000000000000000000000000006484 208.0
HKD2_k127_3037101_5 PFAM Formylglycine-generating sulfatase enzyme K18912 - 1.14.99.50 0.000000000000000000000000000000000000000000000000000000001368 211.0
HKD2_k127_3037101_6 Histidine kinase - - - 0.0000000000000000000000000000000000000000002812 169.0
HKD2_k127_3037101_7 FecR protein - - - 0.000000000000003097 85.0
HKD2_k127_309823_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.531e-216 678.0
HKD2_k127_309823_1 acetyl-CoA carboxylase, biotin carboxylase K01965 - 6.4.1.3 1.898e-215 675.0
HKD2_k127_309823_2 S-adenosylhomocysteine deaminase activity K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 494.0
HKD2_k127_309823_3 endoribonuclease L-PSP - - - 0.000000000000000000000000000000000000000000002586 169.0
HKD2_k127_309823_4 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000001395 112.0
HKD2_k127_309823_5 - - - - 0.00000000000000003178 88.0
HKD2_k127_3345628_0 Short-chain dehydrogenase reductase SDR - - - 4.483e-275 936.0
HKD2_k127_3345628_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000007118 246.0
HKD2_k127_3363443_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 2.628e-276 862.0
HKD2_k127_3363443_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 5.844e-216 678.0
HKD2_k127_3363443_2 Uncharacterized protein family (UPF0051) K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000571 612.0
HKD2_k127_3363443_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 485.0
HKD2_k127_3363443_4 Protein of unknown function (DUF1015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 380.0
HKD2_k127_3363443_5 ABC transporter K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003917 256.0
HKD2_k127_3363443_6 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000003818 165.0
HKD2_k127_3363443_7 thiolester hydrolase activity K03186 - 2.5.1.129 0.000000000000000000000001056 108.0
HKD2_k127_3363443_8 Phosphoglycerate kinase K00927 - 2.7.2.3 0.0000009651 52.0
HKD2_k127_3392725_0 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004608 315.0
HKD2_k127_3392725_1 PFAM SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000001001 164.0
HKD2_k127_3392725_2 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000004574 123.0
HKD2_k127_3392725_3 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.00000000000000000000000000003657 118.0
HKD2_k127_3392725_4 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000003966 111.0
HKD2_k127_3392725_5 Recombinase - - - 0.000002205 50.0
HKD2_k127_3460743_0 Sigma-54 factor, Activator interacting domain (AID) K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 501.0
HKD2_k127_3460743_1 ADP-ribosylglycohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 399.0
HKD2_k127_3460743_2 PFAM ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 287.0
HKD2_k127_3460743_3 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009134 263.0
HKD2_k127_3460743_4 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.00000000000000000000000000000000000000000000000000004308 192.0
HKD2_k127_3460743_5 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000005506 175.0
HKD2_k127_3460743_6 OstA-like protein K09774 - - 0.00000000000000000000000000000000000002245 149.0
HKD2_k127_3460743_7 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.000000000000000000000000000000000009865 144.0
HKD2_k127_3460743_8 - - - - 0.00000000000001749 75.0
HKD2_k127_3460743_9 Lipopolysaccharide-assembly, LptC-related - - - 0.00000002877 61.0
HKD2_k127_3465202_0 - - - - 0.000000000000000000000000000000000000000000000000000000002093 206.0
HKD2_k127_3465202_1 Belongs to the small heat shock protein (HSP20) family - - - 0.00000001162 60.0
HKD2_k127_3465202_2 - - - - 0.00026 50.0
HKD2_k127_37142_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0 1210.0
HKD2_k127_37142_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 416.0
HKD2_k127_37142_2 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005681 330.0
HKD2_k127_37142_3 SMART Elongator protein 3 MiaB NifB K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001217 289.0
HKD2_k127_37142_4 ADP-ribosylation factor family K06883 - - 0.0000000000000000000000000000000000000000000000000000000000001337 225.0
HKD2_k127_3742417_0 TatD related DNase K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000427 551.0
HKD2_k127_3742417_1 Protoporphyrinogen oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 355.0
HKD2_k127_3742417_2 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000004222 228.0
HKD2_k127_379030_0 TIGRFAM ATP-dependent helicase HrpB K03579 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004979 347.0
HKD2_k127_379030_1 domain protein - - - 0.0000004386 55.0
HKD2_k127_3799612_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 6.109e-270 846.0
HKD2_k127_3799612_1 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 349.0
HKD2_k127_3799612_2 Cellulose biosynthesis protein BcsQ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004349 331.0
HKD2_k127_3799612_3 N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001532 317.0
HKD2_k127_3799612_4 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 285.0
HKD2_k127_3799612_5 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000005911 228.0
HKD2_k127_3799612_6 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000006534 167.0
HKD2_k127_3801188_0 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000001036 235.0
HKD2_k127_3801188_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000007804 208.0
HKD2_k127_3817512_0 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 486.0
HKD2_k127_3817512_1 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008625 460.0
HKD2_k127_3817512_2 - - - - 0.0000000000000000000000000000000000000000000001339 171.0
HKD2_k127_3817512_3 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000001085 175.0
HKD2_k127_3817512_4 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.000000000000000000000000000000000003149 145.0
HKD2_k127_3817512_5 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.000000000000004291 76.0
HKD2_k127_3878390_0 bacterial OsmY and nodulation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002744 278.0
HKD2_k127_3878390_1 mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000000000000000000000000000000000000001663 243.0
HKD2_k127_3878390_2 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000003387 143.0
HKD2_k127_3878390_3 - - - - 0.000000000000000000000000000000638 124.0
HKD2_k127_3878390_4 - - - - 0.000000000000000000000000007338 111.0
HKD2_k127_3878390_5 hyperosmotic response K04065 - - 0.00000000000000000005936 93.0
HKD2_k127_3878390_6 - - - - 0.0000000000000000004188 89.0
HKD2_k127_3878390_7 - - - - 0.000000000000004593 76.0
HKD2_k127_3878390_8 PFAM glycosyl transferase group 1 K13057 - 2.4.1.245 0.00000000003115 64.0
HKD2_k127_3878390_9 Protein of unknown function (DUF3096) - - - 0.0000000002945 62.0
HKD2_k127_3898744_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1132.0
HKD2_k127_3898744_1 Elongation factor G, domain IV K02355 - - 1.203e-304 947.0
HKD2_k127_3898744_2 H( )-stimulated, divalent metal cation uptake system K03322 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 526.0
HKD2_k127_3898744_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008809 441.0
HKD2_k127_3898744_4 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000001328 140.0
HKD2_k127_3898744_5 PFAM phosphofructokinase K00850 - 2.7.1.11 0.00000000000000000000000000004053 119.0
HKD2_k127_3898744_6 PFAM Positive regulator of sigma(E) RseC MucC K03803 - - 0.00000000006143 70.0
HKD2_k127_3906706_0 Bacterial regulatory protein, Fis family K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 560.0
HKD2_k127_3906706_1 GHKL domain K13598 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006315 475.0
HKD2_k127_3906706_2 Fumarate reductase succinate dehydrogenase flavoprotein K18209 - 1.3.4.1 0.0000002827 53.0
HKD2_k127_39420_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 8.39e-220 687.0
HKD2_k127_39420_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 391.0
HKD2_k127_39420_10 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000329 226.0
HKD2_k127_39420_11 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000000000000000000003644 212.0
HKD2_k127_39420_12 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000000399 214.0
HKD2_k127_39420_13 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000047 197.0
HKD2_k127_39420_14 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000004505 180.0
HKD2_k127_39420_15 Binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000009383 178.0
HKD2_k127_39420_16 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000749 170.0
HKD2_k127_39420_17 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000002084 164.0
HKD2_k127_39420_18 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000005089 155.0
HKD2_k127_39420_19 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000005581 154.0
HKD2_k127_39420_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 349.0
HKD2_k127_39420_20 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000000000002919 151.0
HKD2_k127_39420_21 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000009368 152.0
HKD2_k127_39420_22 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000004751 131.0
HKD2_k127_39420_23 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.0000000000000000000000000000001242 126.0
HKD2_k127_39420_24 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.00000000000000000000000000003765 121.0
HKD2_k127_39420_25 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000002176 106.0
HKD2_k127_39420_26 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000001514 106.0
HKD2_k127_39420_27 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000000001545 103.0
HKD2_k127_39420_28 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000002587 87.0
HKD2_k127_39420_29 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000000005954 71.0
HKD2_k127_39420_3 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003801 328.0
HKD2_k127_39420_30 Belongs to the universal ribosomal protein uL29 family K02904 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000001383 72.0
HKD2_k127_39420_4 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 319.0
HKD2_k127_39420_5 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001087 277.0
HKD2_k127_39420_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001694 273.0
HKD2_k127_39420_7 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005239 267.0
HKD2_k127_39420_8 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 - - 0.00000000000000000000000000000000000000000000000000000000000000000005997 237.0
HKD2_k127_39420_9 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000104 229.0
HKD2_k127_39507_0 Sigma-54 interaction domain K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 590.0
HKD2_k127_39507_1 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 566.0
HKD2_k127_39507_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004333 456.0
HKD2_k127_39507_3 Branched-chain amino acid transport system / permease component K01997 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 376.0
HKD2_k127_39507_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000522 165.0
HKD2_k127_39507_5 7 8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950,K09007,K13940,K17488 - 2.7.6.3,3.5.4.16,3.5.4.39,4.1.2.25 0.000000000000000000000000000000000000000004667 161.0
HKD2_k127_39507_6 diguanylate cyclase - - - 0.0000000000000000000000000008633 128.0
HKD2_k127_39507_7 - - - - 0.0000000000000001237 85.0
HKD2_k127_3967121_0 PFAM Aldehyde dehydrogenase K00131 - 1.2.1.9 2.479e-225 710.0
HKD2_k127_3967121_1 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004429 246.0
HKD2_k127_3967121_2 deoxyhypusine monooxygenase activity - - - 0.000000000000000000000728 101.0
HKD2_k127_3971632_0 galactose-1-phosphate uridylyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 353.0
HKD2_k127_3971632_1 TIGRFAM transcriptional regulator, Rrf2 family - - - 0.00000000000000000000000000000000000000009613 154.0
HKD2_k127_3971632_2 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000005717 152.0
HKD2_k127_3971632_3 PFAM Smr protein MutS2 - - - 0.00000000000000000000000000000000002449 137.0
HKD2_k127_3971632_4 TIGRFAM cytochrome d ubiquinol oxidase, subunit II K00426 - 1.10.3.14 0.00000000000000000000000000000002245 127.0
HKD2_k127_3971632_5 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000003171 76.0
HKD2_k127_3989445_0 GGDEF domain K21088 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 556.0
HKD2_k127_3989445_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002647 439.0
HKD2_k127_3989445_10 Putative regulatory protein - - - 0.00000000000000000000009719 100.0
HKD2_k127_3989445_11 EamA-like transporter family - - - 0.000000000006395 70.0
HKD2_k127_3989445_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 368.0
HKD2_k127_3989445_3 myo-inosose-2 dehydratase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 320.0
HKD2_k127_3989445_4 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008385 311.0
HKD2_k127_3989445_5 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009412 273.0
HKD2_k127_3989445_6 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000000006531 240.0
HKD2_k127_3989445_7 isopentenyl-diphosphate delta-isomerase activity K00949,K01823 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.7.6.2,5.3.3.2 0.000000000000000000000000000000000000000000000000000003148 197.0
HKD2_k127_3989445_8 PFAM Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000000000000000000000003192 166.0
HKD2_k127_3989445_9 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.000000000000000000000000000000000000000005502 161.0
HKD2_k127_4013528_0 HMGL-like K01666 - 4.1.3.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 319.0
HKD2_k127_4013528_1 phosphorelay signal transduction system - - - 0.0000000000000000000000000000000000000001309 154.0
HKD2_k127_4020589_0 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 324.0
HKD2_k127_4020589_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000004407 278.0
HKD2_k127_4020589_2 Putative diguanylate phosphodiesterase - - - 0.00000000000000001292 94.0
HKD2_k127_4064014_0 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004391 501.0
HKD2_k127_4064014_1 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 443.0
HKD2_k127_4064014_10 - - - - 0.000000000000000000000107 104.0
HKD2_k127_4064014_2 Dehydrogenase E1 component K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 429.0
HKD2_k127_4064014_3 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 318.0
HKD2_k127_4064014_4 Nitroreductase K04719 - 1.13.11.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001248 276.0
HKD2_k127_4064014_5 ABC transporter K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007211 243.0
HKD2_k127_4064014_6 Peptidase family M23 K21471 - - 0.0000000000000000000000000000000000000000000000000000000000000000005057 244.0
HKD2_k127_4064014_7 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000000003224 167.0
HKD2_k127_4064014_8 Belongs to the ABC-4 integral membrane protein family. FtsX subfamily K09811 - - 0.0000000000000000000000000000000000000005231 161.0
HKD2_k127_4064014_9 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.000000000000000000000000000000000000001224 153.0
HKD2_k127_4065679_0 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 358.0
HKD2_k127_4065679_1 Formylmethanofuran dehydrogenase, subunit e K11261 - 1.2.7.12 0.00000000000000000000006194 101.0
HKD2_k127_4065679_2 RmuC family K09760 - - 0.000000000000001048 83.0
HKD2_k127_4066156_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002556 461.0
HKD2_k127_4066156_1 Catalyzes the addition of the first glucose residue to the LPS core K02844 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005768 404.0
HKD2_k127_4066156_2 Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core K02848 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003322 273.0
HKD2_k127_4066156_3 COGs COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferase of PMT family - - - 0.000000000000001315 82.0
HKD2_k127_4066156_4 Lipopolysaccharide kinase (Kdo/WaaP) family K07178 - 2.7.11.1 0.000000002131 67.0
HKD2_k127_406778_0 GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 546.0
HKD2_k127_406778_1 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008083 463.0
HKD2_k127_406778_2 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000823 319.0
HKD2_k127_406778_3 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 291.0
HKD2_k127_406778_4 Protein of unknown function (DUF1460) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001417 249.0
HKD2_k127_406778_5 KOW (Kyprides, Ouzounis, Woese) motif. K05785 - - 0.000000000000000000000000000000003533 134.0
HKD2_k127_406778_6 Glutaredoxin K03676 - - 0.000000001752 59.0
HKD2_k127_4102363_0 Cytochrome c K00413 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006146 280.0
HKD2_k127_4107214_0 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000001104 149.0
HKD2_k127_4107214_1 ATPase-coupled phosphate ion transmembrane transporter activity - - - 0.0000000000000000000000072 115.0
HKD2_k127_4107214_2 - - - - 0.0000000001388 65.0
HKD2_k127_4156254_0 General secretory system II, protein E domain protein K02454 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 623.0
HKD2_k127_4156254_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009043 407.0
HKD2_k127_4156254_2 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 311.0
HKD2_k127_4156254_3 PFAM NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001894 277.0
HKD2_k127_4156254_4 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000000000000000000000000000000000000000008097 226.0
HKD2_k127_4170657_0 serine threonine protein kinase - - - 0.000000000000000000000000000000000000000000000000000000000005586 215.0
HKD2_k127_4170657_1 Protein of unknown function (DUF1810) - - - 0.0000000000000000000000000000000000000000000000000000000003288 205.0
HKD2_k127_4177091_0 MotA/TolQ/ExbB proton channel family K03562 - - 0.0000000000000000000000000000000000000000000000000000000008856 207.0
HKD2_k127_4177091_1 Biopolymer transport protein ExbD/TolR K03560 - - 0.0000000000000000000000000000000000000002376 153.0
HKD2_k127_4177091_2 energy transducer activity K03646,K03832 - - 0.0000000001582 70.0
HKD2_k127_4177091_3 YtxH-like protein - - - 0.0000000001753 64.0
HKD2_k127_4180047_0 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 579.0
HKD2_k127_4180047_1 Chalcone and stilbene synthases, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 454.0
HKD2_k127_4180047_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 447.0
HKD2_k127_4180047_3 long-chain fatty acid transporting porin activity K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000563 429.0
HKD2_k127_4180047_4 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000000000000000000000001652 200.0
HKD2_k127_4180047_5 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000003493 182.0
HKD2_k127_4180047_6 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.0000000000000000000000000000000000000000000000592 171.0
HKD2_k127_4180047_7 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000188 151.0
HKD2_k127_4193402_0 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000000000000000000000000001068 193.0
HKD2_k127_4193402_1 Protein of unknown function (DUF1318) - - - 0.0000000000000000000000000000000000000000000002118 174.0
HKD2_k127_4198503_0 4Fe-4S binding domain - - - 2.39e-205 652.0
HKD2_k127_4198503_1 Lipid A core-O-antigen ligase-like enyme K18814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006161 555.0
HKD2_k127_4198503_10 PFAM Rubredoxin-type Fe(Cys)4 protein - GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0017144,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114,GO:0072592 - 0.0000000000000000000001466 98.0
HKD2_k127_4198503_11 KAP family P-loop domain K12460 GO:0000186,GO:0001932,GO:0001934,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005768,GO:0005770,GO:0005829,GO:0007154,GO:0007165,GO:0007166,GO:0007275,GO:0007399,GO:0008150,GO:0009719,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010562,GO:0010604,GO:0010646,GO:0010647,GO:0010720,GO:0010975,GO:0010976,GO:0012505,GO:0019207,GO:0019220,GO:0019222,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0022008,GO:0023051,GO:0023052,GO:0023056,GO:0030154,GO:0030165,GO:0030234,GO:0031323,GO:0031325,GO:0031344,GO:0031346,GO:0031399,GO:0031401,GO:0031410,GO:0031982,GO:0032147,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032991,GO:0033674,GO:0038179,GO:0038180,GO:0042221,GO:0042325,GO:0042327,GO:0043085,GO:0043226,GO:0043227,GO:0043229,GO:0043405,GO:0043406,GO:0043408,GO:0043410,GO:0043549,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0045859,GO:0045860,GO:0045937,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051174,GO:0051239,GO:0051240,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0051716,GO:0051960,GO:0051962,GO:0060255,GO:0060284,GO:0065007,GO:0065009,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071900,GO:0071902,GO:0080090,GO:0097708,GO:0098772,GO:0120035,GO:1902531,GO:1902533,GO:1990089,GO:1990090,GO:2000026 - 0.00000000000000009756 88.0
HKD2_k127_4198503_2 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007 389.0
HKD2_k127_4198503_3 COG1194 A G-specific DNA glycosylase K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 322.0
HKD2_k127_4198503_4 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 291.0
HKD2_k127_4198503_5 PFAM PHP domain protein K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000000000000000000000000007877 250.0
HKD2_k127_4198503_6 G-rich domain on putative tyrosine kinase K16554 - - 0.000000000000000000000000000000000000000000000000000000000000000000001362 244.0
HKD2_k127_4198503_7 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.0000000000000000000000000000000000000000000000000000004919 201.0
HKD2_k127_4198503_8 - - - - 0.0000000000000000000000000000000000000000000000000008656 187.0
HKD2_k127_4198503_9 - - - - 0.000000000000000000000000000000000000000000000004538 179.0
HKD2_k127_4213929_0 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 408.0
HKD2_k127_4213929_1 TOBE domain K02019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007548 381.0
HKD2_k127_4213929_2 LysM domain K16291 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009899 345.0
HKD2_k127_4213929_3 PFAM Sulphate transporter K03321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003174 283.0
HKD2_k127_4213929_4 PFAM ABC transporter K02003 - - 0.00000000000000000000000000000000000000000001052 163.0
HKD2_k127_4213929_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000002201 161.0
HKD2_k127_4213929_7 Glycosyl transferase family 2 - - - 0.000000000000000002198 85.0
HKD2_k127_425273_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000095 545.0
HKD2_k127_425273_1 Mediates influx of magnesium ions K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 370.0
HKD2_k127_425273_2 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007411 271.0
HKD2_k127_425273_3 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000001795 195.0
HKD2_k127_425273_4 metallocarboxypeptidase activity - - - 0.00000000000000000000000000000000000000002543 164.0
HKD2_k127_425273_5 Penicillin-Binding Protein C-terminus Family K05367 - 2.4.1.129 0.00000000000000000000000000000000000000237 150.0
HKD2_k127_425273_6 - - - - 0.00000000000000000008906 91.0
HKD2_k127_425273_7 Cytochrome c - - - 0.00000000001397 69.0
HKD2_k127_4253227_0 NADH-quinone oxidoreductase K00341,K05568,K12139 - 1.6.5.3 5.854e-231 732.0
HKD2_k127_4253227_1 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 2.942e-207 655.0
HKD2_k127_4253227_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000006985 215.0
HKD2_k127_4253227_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000000000000008003 142.0
HKD2_k127_4253227_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000002334 136.0
HKD2_k127_4253227_13 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000000000002353 132.0
HKD2_k127_4253227_14 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000007948 113.0
HKD2_k127_4253227_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0002999 44.0
HKD2_k127_4253227_2 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008932 614.0
HKD2_k127_4253227_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003355 534.0
HKD2_k127_4253227_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005913 464.0
HKD2_k127_4253227_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 425.0
HKD2_k127_4253227_6 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain K00528,K16951 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 357.0
HKD2_k127_4253227_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003896 276.0
HKD2_k127_4253227_8 Metal-dependent phosphohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002219 271.0
HKD2_k127_4253227_9 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000184 263.0
HKD2_k127_4279524_0 Signal transducing histidine kinase homodimeric K03407 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 458.0
HKD2_k127_4279524_1 regulator, PATAN and FRGAF domain-containing - - - 0.000000000000000000000000000000000000002783 161.0
HKD2_k127_4279524_2 PFAM response regulator receiver K03413 - - 0.0000000000000000000000000000000000000126 147.0
HKD2_k127_42881_0 Sodium/calcium exchanger protein K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 357.0
HKD2_k127_42881_1 CO dehydrogenase K07321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 287.0
HKD2_k127_42881_2 Inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000001951 268.0
HKD2_k127_42881_3 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000009388 213.0
HKD2_k127_42881_4 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0022611,GO:0030272,GO:0032502,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 0.000000000000000000000000000000000000001214 156.0
HKD2_k127_42881_5 AMP binding - - - 0.00000000000000000000000000000000000003554 154.0
HKD2_k127_4364131_0 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 0.0 1049.0
HKD2_k127_4364131_1 PFAM ATPase, F1 V1 A1 complex, alpha beta subunit, nucleotide-binding domain K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009296 524.0
HKD2_k127_4364131_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004451 477.0
HKD2_k127_4364131_3 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000002546 213.0
HKD2_k127_4364131_4 ATP hydrolysis coupled proton transport K02110,K02124 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000001362 101.0
HKD2_k127_4364131_5 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008144,GO:0016829,GO:0016840,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:1901681,GO:1904047 4.3.99.3 0.00000000000001386 74.0
HKD2_k127_4364131_6 proton-transporting ATP synthase activity, rotational mechanism K02115 - - 0.00000000000001436 82.0
HKD2_k127_4364131_7 ATP synthase, Delta/Epsilon chain, beta-sandwich domain K02114 - - 0.00000000004303 69.0
HKD2_k127_4364131_8 F0F1-ATPase subunit K02116 - - 0.000000007211 60.0
HKD2_k127_4364131_9 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0006045 51.0
HKD2_k127_4474968_0 Belongs to the glycosyl hydrolase 57 family K16149 - 2.4.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000595 566.0
HKD2_k127_4474968_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 390.0
HKD2_k127_4474968_2 Transcriptional regulator K11921,K19338 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 360.0
HKD2_k127_4474968_3 C4-type zinc ribbon domain K07164 - - 0.0000000000000000000000000000000000000000000002243 177.0
HKD2_k127_4474968_4 - - - - 0.000009226 56.0
HKD2_k127_4496648_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003048 482.0
HKD2_k127_4496648_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009661 444.0
HKD2_k127_4496648_10 Ribosomal protein L34 K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000005343 72.0
HKD2_k127_4496648_11 - - - - 0.000006245 49.0
HKD2_k127_4496648_2 Ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007601 259.0
HKD2_k127_4496648_3 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000006431 253.0
HKD2_k127_4496648_4 Belongs to the TrpF family K01817 - 5.3.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000009172 242.0
HKD2_k127_4496648_5 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000009574 239.0
HKD2_k127_4496648_6 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000006971 195.0
HKD2_k127_4496648_7 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000005815 193.0
HKD2_k127_4496648_8 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000277 106.0
HKD2_k127_4496648_9 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000003009 77.0
HKD2_k127_4513090_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 588.0
HKD2_k127_4513090_1 NeuB family K03856 - 2.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003648 501.0
HKD2_k127_4513090_2 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004505 454.0
HKD2_k127_4513090_3 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002446 446.0
HKD2_k127_4513090_4 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 313.0
HKD2_k127_4513090_5 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000451 310.0
HKD2_k127_4513090_6 prephenate dehydrogenase K00210,K00220,K04517 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 0.00000000000000000000000000000000000000000000000000000000000000000002058 242.0
HKD2_k127_4513090_7 Chorismate mutase type II K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000002554 218.0
HKD2_k127_4513090_8 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.000000000000000000000000000000000000000000000000003339 194.0
HKD2_k127_4514110_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 497.0
HKD2_k127_4514110_1 lyase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004791 265.0
HKD2_k127_4514110_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000003182 222.0
HKD2_k127_4514110_3 part of a sulfur-relay system K11179 GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360 - 0.00000000000000000000000000000000000000000000002201 174.0
HKD2_k127_4514110_4 metal cluster binding K06940 - - 0.00000000000000000000000000000000000000000006277 168.0
HKD2_k127_4514110_5 regulatory protein, FmdB family - - - 0.000000000000001155 79.0
HKD2_k127_4515667_0 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412,K13491 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 345.0
HKD2_k127_4515667_1 Double sensory domain of two-component sensor kinase K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 303.0
HKD2_k127_4515667_2 Methyltransferase, chemotaxis proteins K00575,K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000001544 253.0
HKD2_k127_4515667_3 Two component signalling adaptor domain K03408 - - 0.0000000000000000000000000000000002475 138.0
HKD2_k127_4592689_0 Conserved carboxylase domain K01958 - 6.4.1.1 0.0 1099.0
HKD2_k127_4592689_1 acetyl-CoA carboxylase, biotin carboxylase K01961,K01965 - 6.3.4.14,6.4.1.2,6.4.1.3 0.0000000000000000000000000000000000000000005047 158.0
HKD2_k127_4592689_2 - - - - 0.00000000000000000000000006149 115.0
HKD2_k127_4617420_0 CO dehydrogenase acetyl-CoA synthase complex beta subunit K14138 - 2.3.1.169 4.839e-255 804.0
HKD2_k127_4617420_1 acetyl-CoA catabolic process K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 414.0
HKD2_k127_4636674_0 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000781 390.0
HKD2_k127_4636674_1 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 380.0
HKD2_k127_4636674_2 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001216 284.0
HKD2_k127_4636674_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001409 251.0
HKD2_k127_4636674_4 protein-(glutamine-N5) methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000001462 192.0
HKD2_k127_4636674_5 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000005934 183.0
HKD2_k127_4636674_6 ABC-2 type transporter K09690 - - 0.0000000000000000000000000000000000000000000001008 169.0
HKD2_k127_4636674_7 Transposase IS200 like K07491 - - 0.00000000000000000000000000007644 119.0
HKD2_k127_4679403_0 calcium, potassium:sodium antiporter activity K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 358.0
HKD2_k127_4679403_1 Transposase IS116 IS110 IS902 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005623 352.0
HKD2_k127_4679403_2 PFAM UspA - - - 0.00000000001184 66.0
HKD2_k127_4729448_0 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 314.0
HKD2_k127_4750909_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006628 600.0
HKD2_k127_4750909_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007847 308.0
HKD2_k127_4750909_2 Protein of unknown function (DUF3124) - - - 0.000000000000000000000000000000000000000001965 161.0
HKD2_k127_4750909_3 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.000000000000000000000006174 104.0
HKD2_k127_4782003_0 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 8.465e-206 651.0
HKD2_k127_4782003_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 466.0
HKD2_k127_4782003_2 coenzyme F390 synthetase K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 304.0
HKD2_k127_4782003_3 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000001088 229.0
HKD2_k127_4782003_4 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000007962 241.0
HKD2_k127_4782003_5 - - - - 0.000000000000000000000000000000000000000000001052 169.0
HKD2_k127_4832647_0 serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000526 331.0
HKD2_k127_4832647_1 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005697 241.0
HKD2_k127_4832647_2 PFAM EamA-like transporter family - - - 0.000000000000000000000000000000001971 132.0
HKD2_k127_4832647_3 Universal stress protein family - - - 0.0000000000000000000000000001013 121.0
HKD2_k127_4832647_4 Pentapeptide repeats (9 copies) - - - 0.0000000004976 68.0
HKD2_k127_4878654_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 484.0
HKD2_k127_4878654_1 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 460.0
HKD2_k127_4878654_2 Gram-negative-bacterium-type cell outer membrane assembly K04064,K06186 GO:0006950,GO:0006970,GO:0008150,GO:0009628,GO:0050896 - 0.00000000000000000000001212 104.0
HKD2_k127_4878654_3 Modulates RecA activity K03565 - - 0.000000000000001461 82.0
HKD2_k127_501581_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 1.498e-271 843.0
HKD2_k127_501581_1 Acetyl-coenzyme A transporter 1 K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 528.0
HKD2_k127_501581_10 zinc-ribbon domain - - - 0.0000000000000000000000000000000000000000001012 172.0
HKD2_k127_501581_11 MgtC family K07507 - - 0.000000000000000000000000000000000000002635 154.0
HKD2_k127_501581_12 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000002935 128.0
HKD2_k127_501581_2 denitrification pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 469.0
HKD2_k127_501581_3 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 453.0
HKD2_k127_501581_4 SMP-30/Gluconolaconase/LRE-like region K14274 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 343.0
HKD2_k127_501581_5 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008165 339.0
HKD2_k127_501581_6 Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) K03620,K08354 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 311.0
HKD2_k127_501581_7 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07305,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000004081 257.0
HKD2_k127_501581_8 proteolysis K07059 - - 0.0000000000000000000000000000000000000000000000000000000000002237 218.0
HKD2_k127_501581_9 Domain of unknown function (DUF4412) - - - 0.000000000000000000000000000000000000000000001953 171.0
HKD2_k127_5112381_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 4.771e-237 740.0
HKD2_k127_5112381_1 Ammonium Transporter Family K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006098 574.0
HKD2_k127_5112381_10 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.00000000002933 74.0
HKD2_k127_5112381_11 GAF domain K02584 - - 0.0000002482 55.0
HKD2_k127_5112381_12 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.000005543 51.0
HKD2_k127_5112381_2 Ammonium Transporter K03320 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008906 531.0
HKD2_k127_5112381_3 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006711 508.0
HKD2_k127_5112381_4 IMP dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000002576 204.0
HKD2_k127_5112381_5 Nitrogen regulatory protein P-II K04751,K04752 - - 0.0000000000000000000000000000000000000000000001118 171.0
HKD2_k127_5112381_6 helix_turn_helix, cAMP Regulatory protein K21563 - - 0.0000000000000000000000000000000000000000000136 169.0
HKD2_k127_5112381_7 PFAM DsrE DsrF-like family - - - 0.00000000000000000000000000000000000000181 150.0
HKD2_k127_5112381_8 - - - - 0.000000000000000000000000000000000000002808 156.0
HKD2_k127_5112381_9 Belongs to the HesB IscA family K15724 - - 0.0000000000000000000000002253 109.0
HKD2_k127_5141593_0 Hydrogenase formation hypA family K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 483.0
HKD2_k127_5141593_1 hydrogenase expression formation protein HypE K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007916 375.0
HKD2_k127_5141593_2 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 332.0
HKD2_k127_5141593_3 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003029 271.0
HKD2_k127_5141593_4 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001786 265.0
HKD2_k127_5141593_5 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001389 245.0
HKD2_k127_5141593_6 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.00000000000000000000000000000000000000003019 162.0
HKD2_k127_5141593_7 hydrogenase maturation protease K03605 - - 0.0000000000000000000009599 100.0
HKD2_k127_5141593_8 acetyl-CoA catabolic process K00197,K03616 - 2.1.1.245 0.000000000000000000002768 101.0
HKD2_k127_5170047_0 HMGL-like K01666 - 4.1.3.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 343.0
HKD2_k127_5170047_1 PFAM KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.000000000000000000000000000000000000000000002227 171.0
HKD2_k127_5170047_2 ABC transporter, ATP-binding protein K02013 - 3.6.3.34 0.000000000000000000000000000001926 122.0
HKD2_k127_5170266_0 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009067 559.0
HKD2_k127_5170266_1 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 509.0
HKD2_k127_5170266_2 metal-dependent phosphohydrolase HD region - - - 0.00000000000000000000000000000000000000000000000000000000000003598 227.0
HKD2_k127_5170266_3 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000004949 160.0
HKD2_k127_5170266_4 Histidine kinase - - - 0.00000000000000000000000000001108 123.0
HKD2_k127_5170266_5 PFAM response regulator receiver - - - 0.00000000000000000000000000001398 123.0
HKD2_k127_5182101_0 alcohol dehydrogenase K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 435.0
HKD2_k127_5182101_1 Glucose dehydrogenase C-terminus K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 385.0
HKD2_k127_5182101_2 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 365.0
HKD2_k127_5182101_3 Dihydrodipicolinate reductase, C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009434 252.0
HKD2_k127_5182101_4 - - - - 0.000000000000003248 81.0
HKD2_k127_5182101_5 - - - - 0.00000000000001057 80.0
HKD2_k127_5182101_6 negative regulation of DNA recombination K07456 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.000000005707 57.0
HKD2_k127_5217541_0 Spermidine synthase K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006007 571.0
HKD2_k127_5299501_0 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000976 435.0
HKD2_k127_5299501_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009226 414.0
HKD2_k127_5299501_2 PFAM binding-protein-dependent transport systems inner membrane component K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 416.0
HKD2_k127_5302340_0 kinase activity K01006,K01007 - 2.7.9.1,2.7.9.2 2.59e-247 777.0
HKD2_k127_5302340_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 476.0
HKD2_k127_5302340_2 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000008155 224.0
HKD2_k127_5302340_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000004579 177.0
HKD2_k127_5314296_0 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 621.0
HKD2_k127_5314296_1 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003533 355.0
HKD2_k127_5314296_2 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004286 306.0
HKD2_k127_5314296_3 lyase activity - - - 0.0000000000000000000000000000000000000000000002056 190.0
HKD2_k127_5314296_4 Uncharacterized protein conserved in bacteria (DUF2147) - - - 0.00000000000000000000000000000000000001118 149.0
HKD2_k127_5314296_5 - - - - 0.000000000000000000000000008901 111.0
HKD2_k127_5314296_6 - - - - 0.000000000003901 78.0
HKD2_k127_5314296_7 cyclic diguanylate phosphodiesterase - - - 0.00000000002229 72.0
HKD2_k127_5321191_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 6.956e-229 715.0
HKD2_k127_5321191_1 Elongation factor SelB, winged helix K03833 - - 1.62e-218 694.0
HKD2_k127_5321191_10 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.000000000000000000000000000000000000003236 152.0
HKD2_k127_5321191_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003207 601.0
HKD2_k127_5321191_3 Evidence 2b Function of strongly homologous gene - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000495 576.0
HKD2_k127_5321191_4 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 516.0
HKD2_k127_5321191_5 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001999 441.0
HKD2_k127_5321191_6 aminopeptidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009436 412.0
HKD2_k127_5321191_7 Large family of predicted nucleotide-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 335.0
HKD2_k127_5321191_8 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567 2.7.7.60 0.00000000000000000000000000000000000000000000000000000000583 206.0
HKD2_k127_5321191_9 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000002266 197.0
HKD2_k127_5350579_0 Surface antigen K07277 - - 3.546e-255 807.0
HKD2_k127_5350579_1 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001988 394.0
HKD2_k127_5350579_2 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003864 394.0
HKD2_k127_5350579_3 Protein of unknown function (DUF1009) K09949 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004236 252.0
HKD2_k127_5350579_4 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000000002219 179.0
HKD2_k127_5350579_5 lyase activity - - - 0.00000000000000000000000000000000003927 142.0
HKD2_k127_5350579_6 PFAM Outer membrane K06142 - - 0.0000000000000000414 88.0
HKD2_k127_5352818_0 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 447.0
HKD2_k127_5352818_1 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007333 374.0
HKD2_k127_5352818_2 Protein of unknown function (DUF1009) K09949 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001241 268.0
HKD2_k127_5352818_3 diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000001673 274.0
HKD2_k127_5352818_4 denitrification pathway - - - 0.0000000000000000000000000000000000000000000000002966 185.0
HKD2_k127_5352818_5 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K16363 - 3.5.1.108,4.2.1.59 0.000000000000000000000000000000000000000916 150.0
HKD2_k127_5352818_6 heme-binding sites - - - 0.00000000000000000000000000000000000000413 156.0
HKD2_k127_5352818_7 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000008746 148.0
HKD2_k127_5352818_8 Belongs to the UPF0754 family - - - 0.000001071 58.0
HKD2_k127_5352818_9 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0001018 47.0
HKD2_k127_5367978_0 TIGRFAM acetylornithine and succinylornithine K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 528.0
HKD2_k127_5367978_1 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 463.0
HKD2_k127_5367978_10 Ribosomal protein S16 K02959 - - 0.000000000000000000000000004723 111.0
HKD2_k127_5367978_2 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 373.0
HKD2_k127_5367978_3 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 297.0
HKD2_k127_5367978_4 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 298.0
HKD2_k127_5367978_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000005813 257.0
HKD2_k127_5367978_6 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000003849 174.0
HKD2_k127_5367978_7 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000001323 156.0
HKD2_k127_5367978_8 PFAM CBS domain - - - 0.0000000000000000000000000000000000000006062 153.0
HKD2_k127_5367978_9 Belongs to the UPF0109 family K06960 - - 0.00000000000000000000000000000001254 129.0
HKD2_k127_5384089_0 retrograde transport, endosome to Golgi K07095 - - 0.00000000000000000000000000000000000000000002276 165.0
HKD2_k127_5384089_1 MarC family integral membrane protein - - - 0.00000000000000000000000000000000000000002259 160.0
HKD2_k127_5384089_2 PFAM Class I peptide chain release factor - - - 0.0000000000000000000000000000000000000003899 152.0
HKD2_k127_5384089_3 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000001129 126.0
HKD2_k127_5536250_0 methyltransferase K03149,K15256 GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0042221,GO:0050896,GO:0051716,GO:0070887,GO:0071241,GO:0071248,GO:0071281 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009106 308.0
HKD2_k127_5536250_1 Phospholipid methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000001218 210.0
HKD2_k127_5536250_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000004649 61.0
HKD2_k127_5557951_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 373.0
HKD2_k127_5557951_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 329.0
HKD2_k127_5557951_2 HD domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 297.0
HKD2_k127_5557951_3 oxidoreductase K10960 - 1.3.1.111,1.3.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000001141 261.0
HKD2_k127_5557951_4 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000007047 166.0
HKD2_k127_5557951_5 Universal stress protein family - - - 0.00000000000000000000000000000000000000000166 161.0
HKD2_k127_5557951_6 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.000000000000000000000000000000000000005229 150.0
HKD2_k127_5557951_7 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K03832 - - 0.000000000000000000000000000000000000006178 156.0
HKD2_k127_5557951_8 - - - - 0.000000000000000000000000000009929 119.0
HKD2_k127_5557951_9 proteolysis K03665 - - 0.000000000000000000000000000038 122.0
HKD2_k127_5558797_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005925 458.0
HKD2_k127_5558797_1 - - - - 0.00000000000000000006798 91.0
HKD2_k127_5558797_2 nuclease activity K06218 - - 0.00000000000005779 75.0
HKD2_k127_5558797_3 Di-haem cytochrome c peroxidase - - - 0.0000000000002431 74.0
HKD2_k127_5611288_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005568 372.0
HKD2_k127_5611288_1 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000005412 231.0
HKD2_k127_5611288_2 HDIG domain protein K06950 - - 0.0000000000000000000000000000000000000000000000000000000000000001021 227.0
HKD2_k127_5611288_3 helix_turn_helix, mercury resistance K13640 - - 0.000000000000000000000000000000137 127.0
HKD2_k127_5624617_0 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001232 261.0
HKD2_k127_5624617_1 translation initiation factor activity K06996 - - 0.00000000000000000000000000000000000001624 152.0
HKD2_k127_5624617_2 Protein of unknown function (DUF498/DUF598) - - - 0.000000000000000000000000000000009139 130.0
HKD2_k127_5624617_3 Protein of unknown function (DUF1232) - - - 0.0000000000000000000001546 101.0
HKD2_k127_5624617_4 - - - - 0.00000000004978 68.0
HKD2_k127_5671662_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1070.0
HKD2_k127_5671662_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000000000000000000000000000006626 199.0
HKD2_k127_5671662_2 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000006239 99.0
HKD2_k127_5725953_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 582.0
HKD2_k127_5725953_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 402.0
HKD2_k127_5725953_2 Mur ligase, middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 315.0
HKD2_k127_5725953_3 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004546 291.0
HKD2_k127_5725953_4 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000001605 190.0
HKD2_k127_5740538_0 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K02297 - 1.10.3.10,1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001868 315.0
HKD2_k127_5740538_1 oxidase, subunit IV K02277 - 1.9.3.1 0.00000000000003115 76.0
HKD2_k127_5740538_2 Cytochrome c oxidase, subunit III K02276,K02299 - 1.9.3.1 0.0000000001115 62.0
HKD2_k127_5744508_0 Domain in cystathionine beta-synthase and other proteins. K07182 - - 3.839e-258 810.0
HKD2_k127_5744508_1 PFAM phosphofructokinase K00850 - 2.7.1.11 0.000000000000000000000000000000000006379 139.0
HKD2_k127_5744508_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.00000000000000000000000000000000001115 142.0
HKD2_k127_5845865_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 7.527e-237 768.0
HKD2_k127_5845865_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 438.0
HKD2_k127_5845865_2 addiction module killer protein - - - 0.00000000000000000000000000000002696 128.0
HKD2_k127_5845865_3 Transcriptional regulator - - - 0.00000000000000000000000000002707 119.0
HKD2_k127_5845865_5 SMART Tetratricopeptide domain protein - - - 0.00000001038 62.0
HKD2_k127_5845865_6 TPR repeat - - - 0.00000001691 59.0
HKD2_k127_5856889_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 5.544e-200 630.0
HKD2_k127_5856889_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009963 489.0
HKD2_k127_5856889_2 Nucleotidyl transferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000046 369.0
HKD2_k127_5856889_3 TIGRFAM arginyl-tRNA synthetase K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.0000000000001241 71.0
HKD2_k127_5856889_4 12 heme-binding sites - - - 0.0000001901 57.0
HKD2_k127_5887246_0 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 465.0
HKD2_k127_5887246_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09695 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004276 357.0
HKD2_k127_5887246_2 ABC-2 type transporter K09694 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 345.0
HKD2_k127_5887246_3 Phospholipase, patatin family K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001363 284.0
HKD2_k127_5887246_4 Domain of unknown function (DUF3842) - - - 0.00000000000000000000000000005979 117.0
HKD2_k127_5903863_0 Protein of unknown function (DUF3641) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 293.0
HKD2_k127_5903863_1 transferase activity, transferring glycosyl groups K20742 - 3.4.14.13 0.000000000000000000000000000000000000000000000000000000000000001993 225.0
HKD2_k127_5903863_2 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07305,K12267 GO:0003674,GO:0003824,GO:0008113,GO:0008150,GO:0008152,GO:0009405,GO:0016491,GO:0016667,GO:0016671,GO:0044419,GO:0051704,GO:0055114 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000001836 189.0
HKD2_k127_5903863_3 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000000000000000000000000000000000000001015 185.0
HKD2_k127_5903863_4 Protein of unknown function (DUF1624) - - - 0.00000000000000000001603 94.0
HKD2_k127_6014640_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 383.0
HKD2_k127_6014640_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005469 289.0
HKD2_k127_6014640_2 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000002127 268.0
HKD2_k127_6014640_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000000000000000000000000004118 245.0
HKD2_k127_6014640_4 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000000000000007076 230.0
HKD2_k127_6014640_5 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000005506 221.0
HKD2_k127_6014640_6 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.0000000000000000000000000000000226 130.0
HKD2_k127_6019244_0 Transglycosylase SLT domain K08309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000942 423.0
HKD2_k127_6019244_2 Tetratricopeptide repeat - - - 0.0007058 50.0
HKD2_k127_6033462_0 transferase activity, transferring glycosyl groups K02844 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001302 317.0
HKD2_k127_6033462_1 glycosyl transferase group 1 - - - 0.000000000379 63.0
HKD2_k127_60413_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005988 453.0
HKD2_k127_60413_1 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 437.0
HKD2_k127_60413_10 belongs to the Fur family K02076,K03711,K09823 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000004796 194.0
HKD2_k127_60413_11 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 0.0000000000000000000000000000000000000000000000001003 183.0
HKD2_k127_60413_12 SMART Cold shock protein K03704 - - 0.000000000000000000000000004398 111.0
HKD2_k127_60413_13 - - - - 0.000000000000000000005507 97.0
HKD2_k127_60413_14 Alcohol dehydrogenase GroES-like domain - - - 0.000002219 50.0
HKD2_k127_60413_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 404.0
HKD2_k127_60413_3 AAA domain, putative AbiEii toxin, Type IV TA system K09817 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000548 348.0
HKD2_k127_60413_4 ABC 3 transport family K09816 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003993 312.0
HKD2_k127_60413_5 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005654 299.0
HKD2_k127_60413_6 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001362 302.0
HKD2_k127_60413_7 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.000000000000000000000000000000000000000000000000000000000000000003876 236.0
HKD2_k127_60413_8 wide pore channel activity K07267 - - 0.00000000000000000000000000000000000000000000000000000000000002016 224.0
HKD2_k127_60413_9 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000004524 218.0
HKD2_k127_6046423_0 Bacterial DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1187.0
HKD2_k127_6046423_1 Penicillin-binding protein OB-like domain K05366 - 2.4.1.129,3.4.16.4 2.964e-257 814.0
HKD2_k127_6046423_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 544.0
HKD2_k127_6046423_3 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008287 505.0
HKD2_k127_6046423_4 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003482 458.0
HKD2_k127_6046423_5 PFAM PfkB K00856 - 2.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 397.0
HKD2_k127_6046423_6 DUF218 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001626 279.0
HKD2_k127_6046423_7 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000000003392 213.0
HKD2_k127_6046423_8 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000001418 102.0
HKD2_k127_6137517_0 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004293 279.0
HKD2_k127_6137517_1 ATPase-coupled phosphate ion transmembrane transporter activity - - - 0.00000000000000000000000002021 120.0
HKD2_k127_6137517_2 - - - - 0.00007244 48.0
HKD2_k127_6137517_3 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.00008456 46.0
HKD2_k127_6255783_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000001215 217.0
HKD2_k127_6255783_1 - - - - 0.0000000000000000000000000000000000000000000006439 170.0
HKD2_k127_6255783_2 Uroporphyrinogen decarboxylase (URO-D) K01599 - 4.1.1.37 0.00000000000004392 76.0
HKD2_k127_6275065_0 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000001743 229.0
HKD2_k127_6275065_1 Glycine-zipper domain - - - 0.000000000000000000000000000000000000000000000000000000007627 203.0
HKD2_k127_6275065_2 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000002169 198.0
HKD2_k127_6275065_3 - - - - 0.00000000000000000000000009036 115.0
HKD2_k127_6293803_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 485.0
HKD2_k127_6293803_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 315.0
HKD2_k127_6361819_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 583.0
HKD2_k127_6361819_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004051 548.0
HKD2_k127_6361819_2 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000549 454.0
HKD2_k127_6361819_3 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002525 256.0
HKD2_k127_6361819_4 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000000000000000000000000000000001753 217.0
HKD2_k127_6361819_5 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.0000000000000000000000000000000000000000000000000000001359 207.0
HKD2_k127_6389023_0 Arginyl tRNA synthetase N terminal dom K01887 - 6.1.1.19 6.81e-198 630.0
HKD2_k127_6389023_1 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 418.0
HKD2_k127_6412836_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 2.394e-285 898.0
HKD2_k127_6412836_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 579.0
HKD2_k127_6412836_10 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000000000007101 95.0
HKD2_k127_6412836_11 COGs COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain K11618 - - 0.00000000000000002198 87.0
HKD2_k127_6412836_12 Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives - - - 0.00000000000001117 81.0
HKD2_k127_6412836_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 331.0
HKD2_k127_6412836_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008733 277.0
HKD2_k127_6412836_4 phosphoesterase RecJ domain protein K06881 GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000007233 265.0
HKD2_k127_6412836_5 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000006337 243.0
HKD2_k127_6412836_6 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000009266 242.0
HKD2_k127_6412836_7 PAS fold - - - 0.000000000000000000000000000000000000000004125 166.0
HKD2_k127_6412836_8 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000000000002358 143.0
HKD2_k127_6412836_9 Histidine kinase - - - 0.000000000000000000000000000000002009 133.0
HKD2_k127_6418607_0 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K01919,K01920,K05844 GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.2,6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 375.0
HKD2_k127_6418607_1 beta-keto acid cleavage enzyme K18013 - 2.3.1.247 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005875 330.0
HKD2_k127_6418607_2 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000006561 240.0
HKD2_k127_6418607_3 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000318 186.0
HKD2_k127_6418607_4 transferase activity, transferring glycosyl groups K00786 - - 0.000000000000000000000000000000000000000000745 168.0
HKD2_k127_6418607_5 Glycosyl transferase family 2 - - - 0.000000000000000000000000006074 112.0
HKD2_k127_6418607_6 Glycosyltransferase like family 2 K07011 - - 0.0000441 51.0
HKD2_k127_6423207_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000226 585.0
HKD2_k127_6423207_1 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 415.0
HKD2_k127_6423207_2 Protein of unknown function DUF89 K09116 - - 0.000000000000000000000000000000000000000000000000000000000000000000006106 243.0
HKD2_k127_6423207_3 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000003698 229.0
HKD2_k127_6423207_4 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000003103 197.0
HKD2_k127_6423207_5 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.0000000000000000000000000008966 114.0
HKD2_k127_6423207_6 RNA recognition motif - - - 0.0000000000000000000001036 101.0
HKD2_k127_6423207_7 deoxyhypusine monooxygenase activity K05386 - - 0.00000000000000003413 86.0
HKD2_k127_6423207_8 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000003467 78.0
HKD2_k127_6423207_9 - - - - 0.000000000000001567 79.0
HKD2_k127_6447582_0 CoA binding domain K01905,K09181,K22224 - 6.2.1.13 1.231e-250 784.0
HKD2_k127_6447582_1 Transposase IS200 like - - - 0.00000000000000000000000000000000000000000000000000002668 192.0
HKD2_k127_6447582_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.0000000000000000000000000000000000006464 147.0
HKD2_k127_6483523_0 protein methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007568 512.0
HKD2_k127_6483523_1 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 443.0
HKD2_k127_6483523_2 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 374.0
HKD2_k127_6483523_3 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009603 257.0
HKD2_k127_6483523_4 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000006018 221.0
HKD2_k127_6483523_5 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000009007 187.0
HKD2_k127_6483523_6 Wzt C-terminal domain K09691 - - 0.00000000000000000000002233 101.0
HKD2_k127_6483523_7 methyltransferase - - - 0.0000000000000000000001899 107.0
HKD2_k127_6483523_8 acetyltransferase K03789 - 2.3.1.128 0.00000000000000000003374 96.0
HKD2_k127_6483523_9 Glycosyl transferase, family 2 - - - 0.00004194 54.0
HKD2_k127_6503444_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 3.608e-292 905.0
HKD2_k127_6503444_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 6.942e-200 632.0
HKD2_k127_6503444_2 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000067 376.0
HKD2_k127_6503444_3 (AIR) carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002633 271.0
HKD2_k127_6503444_4 glycerophosphoryl diester phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001539 244.0
HKD2_k127_6503444_5 thiamine biosynthesis protein ThiS K03154 - - 0.00000000005293 64.0
HKD2_k127_6503444_6 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000005937 54.0
HKD2_k127_6572235_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1576.0
HKD2_k127_6572235_1 FMN binding - - - 0.0000000000000000000000000000003242 129.0
HKD2_k127_6572235_2 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.000000000000000000000000003923 110.0
HKD2_k127_6611963_0 Belongs to the ABC transporter superfamily K02032,K10823 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000267 222.0
HKD2_k127_6611963_1 ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000001379 217.0
HKD2_k127_6611963_2 phosphorelay signal transduction system - - - 0.000000000000000000000000000002619 125.0
HKD2_k127_6611963_3 PAS fold - - - 0.0000000000000005353 87.0
HKD2_k127_6624892_0 TIGRFAM molybdenum cofactor synthesis K03750,K07219 - 2.10.1.1 1.488e-219 695.0
HKD2_k127_6624892_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 9.874e-204 641.0
HKD2_k127_6624892_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 7.434e-197 619.0
HKD2_k127_6624892_3 Mo-molybdopterin cofactor metabolic process K02379 - - 0.0000000000000000000000000000000000000000000000000000000000008016 218.0
HKD2_k127_6624892_4 Probable molybdopterin binding domain - - - 0.000000000000000000000000000000000000000000000000000000000006184 212.0
HKD2_k127_6624892_5 MOSC domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000002599 199.0
HKD2_k127_6624892_6 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000004515 147.0
HKD2_k127_6624892_7 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000005662 86.0
HKD2_k127_6654849_0 Argininosuccinate lyase C-terminal K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002972 494.0
HKD2_k127_6654849_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 353.0
HKD2_k127_6654849_2 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000004131 249.0
HKD2_k127_6654849_3 Protein of unknown function DUF58 - - - 0.000000000000000000000000000000000000000003603 168.0
HKD2_k127_6654849_4 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000004083 152.0
HKD2_k127_6685809_0 membrane transporter protein K07090 - - 2.524e-202 636.0
HKD2_k127_6685809_1 phosphorelay signal transduction system K02584,K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 508.0
HKD2_k127_6685809_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009811 251.0
HKD2_k127_6685809_3 helix_turn_helix gluconate operon transcriptional repressor K03710 - - 0.0000000000000000000000000000001069 133.0
HKD2_k127_6685809_4 Calcineurin-like phosphoesterase K07098 - - 0.0000000000000000000000000001105 115.0
HKD2_k127_6685809_5 COG0589 Universal stress protein UspA and related nucleotide-binding proteins K20989 - - 0.00000000000249 72.0
HKD2_k127_6700272_0 indolepyruvate ferredoxin oxidoreductase activity K00179,K08941 - 1.2.7.8 1.677e-194 620.0
HKD2_k127_6700272_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003769 567.0
HKD2_k127_6700272_2 coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 415.0
HKD2_k127_6700272_3 amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 302.0
HKD2_k127_6700272_4 amino acid-binding ACT - - - 0.000000000000000000000000000000000000000000000000002332 186.0
HKD2_k127_6700272_5 membrane K00389 - - 0.000000000000000000000000000000000000000000005364 167.0
HKD2_k127_6700272_6 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000003381 131.0
HKD2_k127_6711042_0 Bacterial Type VI secretion, VC_A0110, EvfL, ImpJ, VasE K11893 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 484.0
HKD2_k127_6711042_1 ImcF-related N-terminal domain K11891 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009168 465.0
HKD2_k127_6711042_2 HD domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006178 259.0
HKD2_k127_6711042_3 Type VI secretion system protein DotU K11892 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002539 256.0
HKD2_k127_6711042_4 Type VI secretion lipoprotein, VasD, EvfM, TssJ, VC_A0113 - - - 0.00000000000000000000000002872 117.0
HKD2_k127_6711042_5 helix_turn_helix, Lux Regulon - - - 0.00000000000000000001281 100.0
HKD2_k127_674216_0 PFAM ResB family protein K07399 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 408.0
HKD2_k127_674216_1 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002521 378.0
HKD2_k127_674216_2 PFAM Type II secretion system protein E K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000302 282.0
HKD2_k127_678046_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000003292 213.0
HKD2_k127_678046_1 Protein of unknown function DUF47 K07220 - - 0.000000000000000000000000000000000000000000000000008963 186.0
HKD2_k127_678046_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000006195 169.0
HKD2_k127_678046_3 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000002772 139.0
HKD2_k127_678046_4 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000001606 97.0
HKD2_k127_6782103_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01535 - 3.6.3.6 9.255e-298 933.0
HKD2_k127_6782103_1 Polyprenyl synthetase K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003154 353.0
HKD2_k127_6782103_2 FtsZ-dependent cytokinesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000001385 241.0
HKD2_k127_6782103_3 ferrous iron binding K06990,K09141 - - 0.00000000000000000000000000000000000000000000000000000000000001037 219.0
HKD2_k127_6782103_4 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000000000001799 205.0
HKD2_k127_6782103_5 TrkA-C domain - - - 0.0000000000000000000000000000000000000000000000000044 189.0
HKD2_k127_6782103_6 SurA N-terminal domain K03771 - 5.2.1.8 0.0000000000000000000000000000000000000004053 158.0
HKD2_k127_6782103_7 Domain of unknown function (DUF4388) - - - 0.0000000000000000000004633 111.0
HKD2_k127_6812792_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 5.535e-312 974.0
HKD2_k127_6812792_1 Protein of unknown function, DUF255 K06888 - - 2.015e-234 742.0
HKD2_k127_6812792_10 Radical SAM K04034 - 1.21.98.3 0.00000000000008967 76.0
HKD2_k127_6812792_11 Universal stress protein - - - 0.00000000000009079 81.0
HKD2_k127_6812792_13 transcriptional K22299 - - 0.0001903 51.0
HKD2_k127_6812792_2 PFAM magnesium chelatase ChlI subunit K07391 - - 1.283e-205 651.0
HKD2_k127_6812792_3 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 2.247e-195 616.0
HKD2_k127_6812792_4 Belongs to the dGTPase family. Type 2 subfamily K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002987 459.0
HKD2_k127_6812792_5 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000004107 250.0
HKD2_k127_6812792_6 SMART Signal transduction response regulator, receiver domain - - - 0.0000000000000000000000000000000000000000000000000002637 195.0
HKD2_k127_6812792_8 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000173 81.0
HKD2_k127_6812792_9 DUF167 - - - 0.000000000000006163 78.0
HKD2_k127_6895658_0 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001801 265.0
HKD2_k127_6895658_1 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004854 269.0
HKD2_k127_6895658_2 Protein phosphatase 2C domain K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000008395 255.0
HKD2_k127_6895658_3 STAS domain K04749 - - 0.0000000000000000000000003577 108.0
HKD2_k127_6895658_4 anti-sigma regulatory factor K04757 - 2.7.11.1 0.000000000000000000000009343 105.0
HKD2_k127_6895658_5 TonB-dependent receptor - - - 0.0000001274 65.0
HKD2_k127_6919089_0 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 518.0
HKD2_k127_6919089_1 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K15022 - 1.17.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 369.0
HKD2_k127_6919089_2 PFAM Methylenetetrahydrofolate reductase K00297,K00547 - 1.5.1.20,2.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 361.0
HKD2_k127_6919089_3 Methylene-tetrahydrofolate reductase C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000001082 238.0
HKD2_k127_6919089_4 - - - - 0.0000000000000000000000000000000000000000000000000000004313 199.0
HKD2_k127_6919089_5 aminopeptidase N - - - 0.00006586 51.0
HKD2_k127_6940457_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1083.0
HKD2_k127_6940457_1 Domain of unknown function (DUF4139) - - - 7.491e-198 627.0
HKD2_k127_6940457_10 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000001144 79.0
HKD2_k127_6940457_2 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 483.0
HKD2_k127_6940457_3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00174,K00186 - 1.2.7.11,1.2.7.3,1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009846 476.0
HKD2_k127_6940457_4 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000002379 240.0
HKD2_k127_6940457_5 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000000003917 216.0
HKD2_k127_6940457_7 SMART Cold shock protein K03704 - - 0.0000000000000000000000003804 105.0
HKD2_k127_6940457_8 methyltransferase activity - - - 0.000000000000000000002934 98.0
HKD2_k127_6940457_9 electron transfer activity K00428 - 1.11.1.5 0.0000000000000000004237 91.0
HKD2_k127_6953190_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 5e-324 1007.0
HKD2_k127_6953190_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000229 635.0
HKD2_k127_6953190_10 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000000000001033 138.0
HKD2_k127_6953190_11 - - - - 0.0000000000000000000000000000000009735 136.0
HKD2_k127_6953190_12 - - - - 0.0000000000000000000000000001875 130.0
HKD2_k127_6953190_13 Belongs to the bacterial ribosomal protein bL32 family K02911 GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - 0.00000000000000000000002164 100.0
HKD2_k127_6953190_14 cell cycle K05589,K12065,K13052 - - 0.000000000000009035 78.0
HKD2_k127_6953190_15 Glycosyl hydrolase family 57 - - - 0.00000002709 57.0
HKD2_k127_6953190_16 PilZ domain - - - 0.00000271 57.0
HKD2_k127_6953190_2 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003813 445.0
HKD2_k127_6953190_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004989 431.0
HKD2_k127_6953190_4 PFAM Cys Met metabolism pyridoxal-phosphate-dependent K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 390.0
HKD2_k127_6953190_5 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 367.0
HKD2_k127_6953190_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 350.0
HKD2_k127_6953190_7 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000005274 216.0
HKD2_k127_6953190_8 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.000000000000000000000000000000000000000000000001339 178.0
HKD2_k127_6953190_9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000002 170.0
HKD2_k127_7047276_0 ABC transporter, ATP-binding protein K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000035 310.0
HKD2_k127_7047276_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009746 292.0
HKD2_k127_7047276_2 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000000000000000000000000000009535 170.0
HKD2_k127_7047276_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000001158 166.0
HKD2_k127_7047276_4 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000000000000000001906 165.0
HKD2_k127_7068335_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 414.0
HKD2_k127_7068335_1 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 321.0
HKD2_k127_7068335_2 Diacylglycerol kinase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007294 249.0
HKD2_k127_7068335_3 6-carboxyhexanoate--CoA ligase K01906 - 6.2.1.14 0.000000000000000000000000000000000000000000000000000000000005635 217.0
HKD2_k127_7068335_4 Phosphate transporter family K03306 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.0000000000000000000000000000000000000000000004494 169.0
HKD2_k127_7068335_5 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000000000000000000000000004462 169.0
HKD2_k127_7085468_0 - - - - 0.00000000000000000000000000000000000000000001382 166.0
HKD2_k127_7085468_1 Pfam:Pyridox_oxidase - - - 0.00000057 53.0
HKD2_k127_7085468_2 Nucleotidyl transferase K00963 - 2.7.7.9 0.00007088 48.0
HKD2_k127_7085773_0 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004243 274.0
HKD2_k127_7085773_1 ROK family K00845,K13967,K19979,K20433 - 2.7.1.188,2.7.1.2,2.7.1.214,2.7.1.60,5.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000004242 249.0
HKD2_k127_7085773_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000003811 195.0
HKD2_k127_7085773_3 4Fe-4S ferredoxin iron-sulfur binding domain protein K00176 - 1.2.7.3 0.00000000000000000001477 92.0
HKD2_k127_7096049_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000001553 215.0
HKD2_k127_7096049_1 Histidine kinase - - - 0.0000000000000000000000002084 123.0
HKD2_k127_7096049_2 Uncharacterized ACR, COG1678 - - - 0.0000000000001493 74.0
HKD2_k127_7096049_3 Transcriptional regulator K07735 - - 0.00000000008007 64.0
HKD2_k127_7112428_0 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 319.0
HKD2_k127_7112428_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000011 200.0
HKD2_k127_7112428_2 nucleotidyltransferase activity K07075 - - 0.000000000000000000000000002514 117.0
HKD2_k127_7112428_3 AP endonuclease family 2 K01151 - 3.1.21.2 0.00000000000000000000000008415 109.0
HKD2_k127_7124881_0 SMP-30 Gluconolaconase LRE domain protein K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004541 407.0
HKD2_k127_7124881_1 oxidoreductase activity, acting on CH-OH group of donors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003525 259.0
HKD2_k127_7124881_3 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.00000415 51.0
HKD2_k127_7124881_4 Catalyzes the reversible epimerization of cellobiose to 4-O-beta-D-glucopyranosyl-D-mannose (Glc-Man) K16213 - 5.1.3.11 0.00005047 47.0
HKD2_k127_7156153_0 Heat shock 70 kDa protein K04043 - - 1.136e-321 994.0
HKD2_k127_7156153_1 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 520.0
HKD2_k127_7156153_10 Phosphoribosyl-AMP cyclohydrolase K01496,K11755 - 3.5.4.19,3.6.1.31 0.000000000000000000000000000000000000000000000006569 173.0
HKD2_k127_7156153_11 PFAM Pyruvate ferredoxin flavodoxin oxidoreductase K00177 - 1.2.7.3 0.0000000000000000000000000000000000000000000001457 173.0
HKD2_k127_7156153_12 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.00000000000000000000000000000000000000003452 160.0
HKD2_k127_7156153_13 Archaeal transcriptional regulator TrmB - - - 0.0000000000000000000000000000000000000002502 159.0
HKD2_k127_7156153_14 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000004427 153.0
HKD2_k127_7156153_15 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000173 110.0
HKD2_k127_7156153_16 Protein of unknown function (DUF507) - - - 0.0000000000000000000000001792 109.0
HKD2_k127_7156153_17 Protein of unknown function (DUF507) - - - 0.0000000000000000000000003116 108.0
HKD2_k127_7156153_18 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000132 102.0
HKD2_k127_7156153_19 Rubredoxin - - - 0.0000000000000000000008686 96.0
HKD2_k127_7156153_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 459.0
HKD2_k127_7156153_20 Diguanylate cyclase - - - 0.00000000000000001455 96.0
HKD2_k127_7156153_21 Adenosine specific kinase K09129 - - 0.0000000000000006218 78.0
HKD2_k127_7156153_3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 396.0
HKD2_k127_7156153_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000539 368.0
HKD2_k127_7156153_5 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 333.0
HKD2_k127_7156153_6 Belongs to the acetyltransferase family. ArgA subfamily K00619,K14681 GO:0003674,GO:0003824,GO:0004042,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016043,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0040007,GO:0042450,GO:0042802,GO:0042803,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,4.3.2.1 0.00000000000000000000000000000000000000000000000000000000000007523 216.0
HKD2_k127_7156153_7 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000000001173 188.0
HKD2_k127_7156153_8 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000001722 189.0
HKD2_k127_7156153_9 Single-strand binding protein family K03111 - - 0.000000000000000000000000000000000000000000000001752 176.0
HKD2_k127_718125_0 amine dehydrogenase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009038 293.0
HKD2_k127_718125_1 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.000000000000000000000000000000000000000000000003258 185.0
HKD2_k127_718125_2 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000000000000000000000000000000000000001872 153.0
HKD2_k127_718125_3 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000005624 132.0
HKD2_k127_7188405_0 Formate--tetrahydrofolate ligase K01938 - 6.3.4.3 1.666e-264 819.0
HKD2_k127_7188405_1 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004492 376.0
HKD2_k127_7188405_2 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 318.0
HKD2_k127_7188405_3 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003375 246.0
HKD2_k127_7188405_4 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000004136 119.0
HKD2_k127_7210088_0 UV-endonuclease UvdE K13281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 344.0
HKD2_k127_7210088_1 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.000000000000000000000000000000000000000008273 158.0
HKD2_k127_7210088_2 - - - - 0.000000000000000000000000000004871 124.0
HKD2_k127_7259013_0 ACT domain K00928 - 2.7.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001159 579.0
HKD2_k127_7259013_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 542.0
HKD2_k127_7319553_0 COG0058 Glucan phosphorylase - - - 3.398e-265 826.0
HKD2_k127_7319553_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 604.0
HKD2_k127_7319553_2 phosphatase activity K20881 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 293.0
HKD2_k127_7319553_3 Belongs to the ompA family K03286 - - 0.0000000000000000000000000000000000000000000000000000001376 196.0
HKD2_k127_7319553_4 glycosyl transferase family 8 - - - 0.0000000000000006574 85.0
HKD2_k127_7335862_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1724.0
HKD2_k127_7335862_1 Seven times multi-haem cytochrome CxxCH - - - 5.159e-200 632.0
HKD2_k127_7335862_10 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004639 372.0
HKD2_k127_7335862_11 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 374.0
HKD2_k127_7335862_12 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006276 355.0
HKD2_k127_7335862_13 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 353.0
HKD2_k127_7335862_14 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 346.0
HKD2_k127_7335862_15 PFAM cytochrome c assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000643 286.0
HKD2_k127_7335862_16 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003126 281.0
HKD2_k127_7335862_17 Diguanylate cyclase K21084 - 2.7.7.65 0.000000000000000000000000000000000000000000000000000000000000000000000000001996 276.0
HKD2_k127_7335862_18 beta-galactosidase activity K12308 - 3.2.1.23 0.00000000000000000000000000000000000000000000000000000000000000003652 231.0
HKD2_k127_7335862_19 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000001775 226.0
HKD2_k127_7335862_2 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 7.828e-195 616.0
HKD2_k127_7335862_20 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000000004053 193.0
HKD2_k127_7335862_21 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000000000000000000000000000002265 186.0
HKD2_k127_7335862_22 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000000000000000000000000001479 153.0
HKD2_k127_7335862_23 Cyclic nucleotide-monophosphate binding domain - - - 0.0000000000000000000000251 105.0
HKD2_k127_7335862_24 Mo-molybdopterin cofactor metabolic process K03753,K07588 - - 0.00000000000006455 73.0
HKD2_k127_7335862_25 Tetratricopeptide repeat - - - 0.0000000000001075 80.0
HKD2_k127_7335862_26 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000006513 76.0
HKD2_k127_7335862_27 Diguanylate cyclase - - - 0.0000000006801 60.0
HKD2_k127_7335862_28 Single cache domain 3 - - - 0.00000006003 66.0
HKD2_k127_7335862_3 cysteine synthase A K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 466.0
HKD2_k127_7335862_4 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 460.0
HKD2_k127_7335862_5 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006681 445.0
HKD2_k127_7335862_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 441.0
HKD2_k127_7335862_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 433.0
HKD2_k127_7335862_8 Belongs to the MtfA family K09933 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003046 419.0
HKD2_k127_7335862_9 Histone deacetylase domain K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 419.0
HKD2_k127_7348954_0 Metallo-beta-lactamase superfamily K22405 - 1.6.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001518 462.0
HKD2_k127_7348954_1 alkyl hydroperoxide reductase K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004 271.0
HKD2_k127_7348954_2 alkyl hydroperoxide reductase K03386 - 1.11.1.15 0.000000000000000000000005603 103.0
HKD2_k127_7348954_3 TIGRFAM desulfoferrodoxin FeS4 iron-binding domain K05919 - 1.15.1.2 0.0000000006732 61.0
HKD2_k127_7359331_0 Belongs to the GTP cyclohydrolase I type 2 NIF3 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008794 447.0
HKD2_k127_7359331_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009369 334.0
HKD2_k127_7359331_2 ATPases associated with a variety of cellular activities K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004214 265.0
HKD2_k127_7359331_3 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07712 - - 0.0000000000000000000000000000000000000000000000000000000000000001938 234.0
HKD2_k127_7359331_4 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000073 221.0
HKD2_k127_7359331_5 ABC-2 type transporter K01992,K09690 - - 0.00000000000000000000000000000000000000000000000002425 188.0
HKD2_k127_7359331_6 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000008693 152.0
HKD2_k127_7359331_7 Glycosyl transferases group 1 - - - 0.00000000000000000000000000001618 124.0
HKD2_k127_7359331_8 Ribosomal protein S21 K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000007599 94.0
HKD2_k127_7359331_9 Uncharacterized conserved protein (DUF2304) K09153 - - 0.00000001039 63.0
HKD2_k127_7475780_0 ATPase BadF BadG BcrA BcrD type - - - 0.0 1557.0
HKD2_k127_7475780_1 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007665 302.0
HKD2_k127_7475780_2 methyltransferase activity - - - 0.0000000000000000000000000000000000000000000001833 173.0
HKD2_k127_7525116_0 Cytochrome c3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004103 550.0
HKD2_k127_7525116_1 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005727 252.0
HKD2_k127_7525116_2 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001182 249.0
HKD2_k127_7525116_3 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.0000000000000000000000000000000000000000000000000000000000003338 229.0
HKD2_k127_7525116_4 ATP synthesis coupled proton transport K02109,K18682 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000001826 154.0
HKD2_k127_7525116_5 ATP synthesis coupled proton transport K02109 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0016020,GO:0016469,GO:0032991,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 - 0.000000000000000000000000002513 116.0
HKD2_k127_7525116_6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000269 98.0
HKD2_k127_7525116_7 Peptidylprolyl isomerase K03770 - 5.2.1.8 0.0000004386 61.0
HKD2_k127_7615089_0 Sigma-54 interaction domain K07714 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006757 319.0
HKD2_k127_7625189_0 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001875 600.0
HKD2_k127_7625189_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000001451 72.0
HKD2_k127_7625189_2 - - - - 0.0000003413 53.0
HKD2_k127_7679628_0 Mur ligase family, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003994 317.0
HKD2_k127_7679628_1 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000003933 179.0
HKD2_k127_7679628_2 Preprotein translocase subunit K03210 - - 0.0000000000000000000000000000000000000001801 152.0
HKD2_k127_7687750_0 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 3.282e-194 625.0
HKD2_k127_7687750_1 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 435.0
HKD2_k127_7687750_2 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 286.0
HKD2_k127_7687750_3 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000122 50.0
HKD2_k127_7690283_0 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 551.0
HKD2_k127_7690283_1 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000143 480.0
HKD2_k127_7690283_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 469.0
HKD2_k127_7690283_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006815 361.0
HKD2_k127_7690283_4 tRNA 3'-trailer cleavage K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007985 332.0
HKD2_k127_7690283_5 Helix-turn-helix domain - - - 0.00000000000000000000000000002542 126.0
HKD2_k127_7690283_6 RNase_H superfamily K07502 - - 0.0000000000000000000000000005813 115.0
HKD2_k127_7690283_7 Response regulator, receiver - - - 0.000000000000002761 89.0
HKD2_k127_7690283_8 dnaJ homolog subfamily C member K19374 - - 0.000007715 59.0
HKD2_k127_7691363_0 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 2.65e-243 760.0
HKD2_k127_7691363_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 557.0
HKD2_k127_7691363_2 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000002093 102.0
HKD2_k127_7700476_0 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 8.259e-197 625.0
HKD2_k127_7700476_1 PFAM DAHP synthetase I KDSA K03856,K04516 - 2.5.1.54,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006488 546.0
HKD2_k127_7700476_2 Alginate export - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 405.0
HKD2_k127_7700476_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 370.0
HKD2_k127_7700476_4 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 338.0
HKD2_k127_7700476_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007383 264.0
HKD2_k127_7731142_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000843 456.0
HKD2_k127_7731142_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 350.0
HKD2_k127_7731142_2 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 337.0
HKD2_k127_7731142_3 Domain of unknown function (DUF4143) K07133 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009829 277.0
HKD2_k127_7731142_4 Methylmuconolactone methyl-isomerase - - - 0.00000000003637 68.0
HKD2_k127_7731142_5 - - - - 0.00000001552 62.0
HKD2_k127_7743540_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 3.7e-207 653.0
HKD2_k127_7743540_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 1.664e-203 642.0
HKD2_k127_7743540_2 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000002531 181.0
HKD2_k127_7743540_3 - - - - 0.0000001632 53.0
HKD2_k127_7759594_0 Belongs to the alpha-IPM synthase homocitrate synthase family K02594 - 2.3.3.14 2.524e-227 708.0
HKD2_k127_7759594_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009637 609.0
HKD2_k127_7759594_2 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004409 552.0
HKD2_k127_7759594_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004908 367.0
HKD2_k127_7759594_4 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 327.0
HKD2_k127_7759594_5 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000000000000000000000005956 192.0
HKD2_k127_7759594_6 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000000006709 125.0
HKD2_k127_7759594_7 Transporter associated domain K03699 - - 0.0000000000000003546 79.0
HKD2_k127_7759594_8 pfam yhs - - - 0.000000000000006196 76.0
HKD2_k127_7886159_0 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 305.0
HKD2_k127_7886159_1 Fumarate hydratase (Fumerase) K01676,K01677 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000001343 251.0
HKD2_k127_7886159_2 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000005072 232.0
HKD2_k127_7886159_3 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 0.000000000000000000000000000000000000000000000000001245 192.0
HKD2_k127_7886159_4 Prokaryotic diacylglycerol kinase K00887,K00901 - 2.7.1.107,2.7.1.66 0.00000000000000000000000000000000000000000000000004273 186.0
HKD2_k127_7886159_5 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.000000000000000000002058 98.0
HKD2_k127_7909932_0 PFAM Nitrate reductase gamma subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000007562 257.0
HKD2_k127_7909932_1 part of a sulfur-relay system K11179 GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360 - 0.000000000000000000000000000000000000000000000000000002948 192.0
HKD2_k127_7909932_2 RsbT co-antagonist protein rsbRD N-terminal domain - - - 0.00000000000000000000000000000000000000000001025 171.0
HKD2_k127_7909932_3 HEAT-like repeat - - - 0.0000000000000000000001473 102.0
HKD2_k127_7909932_4 lyase activity - - - 0.0000000000000001197 83.0
HKD2_k127_7932023_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 9.86e-207 652.0
HKD2_k127_7932023_1 Insulinase (Peptidase family M16) K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003068 461.0
HKD2_k127_7932023_2 Peptidase M16 K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 381.0
HKD2_k127_7932023_3 Lysin motif - - - 0.00000000000000000000000000000003958 138.0
HKD2_k127_7932023_4 Protein of unknown function (DUF1009) K09949 - - 0.00001502 48.0
HKD2_k127_7940507_0 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 335.0
HKD2_k127_7940507_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000003176 237.0
HKD2_k127_7940507_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000058 54.0
HKD2_k127_7983052_0 TIGRFAM formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000391 544.0
HKD2_k127_7983052_1 4Fe-4S dicluster domain K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007895 284.0
HKD2_k127_7983052_2 Necessary for formate dehydrogenase activity K02380 - - 0.000000000000000000000000000000000000001193 159.0
HKD2_k127_7983052_3 Probable molybdopterin binding domain - - - 0.00000000000000000001138 91.0
HKD2_k127_7989441_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 5.854e-315 989.0
HKD2_k127_7989441_1 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004444 544.0
HKD2_k127_7989441_2 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 511.0
HKD2_k127_7989441_3 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 439.0
HKD2_k127_7989441_4 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007115 399.0
HKD2_k127_7989441_5 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 396.0
HKD2_k127_7989441_6 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000000000002073 231.0
HKD2_k127_7989441_7 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0001651 44.0
HKD2_k127_8008966_0 PBP superfamily domain K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003763 396.0
HKD2_k127_8008966_1 ATP synthase subunit J K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008446 401.0
HKD2_k127_8008966_10 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 GO:0003674,GO:0003824,GO:0004766,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.000000002994 59.0
HKD2_k127_8008966_2 myo-inosose-2 dehydratase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 297.0
HKD2_k127_8008966_3 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001121 302.0
HKD2_k127_8008966_4 Binding-protein-dependent transport system inner membrane component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000907 280.0
HKD2_k127_8008966_5 ATPase activity K02010,K02049,K02068,K02071,K06857,K10112 - 3.6.3.30,3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009769 274.0
HKD2_k127_8008966_6 ABC-type tungstate transport system permease component-like protein K05772 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002032 256.0
HKD2_k127_8008966_7 PFAM TrkA-N domain K03499 - - 0.0000000000000000000000000000000000000000000000000000000000000002781 227.0
HKD2_k127_8008966_8 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.000000000000000000000000000000000000000000002484 176.0
HKD2_k127_8008966_9 Putative regulatory protein - - - 0.00000000000000000000002217 104.0
HKD2_k127_8035619_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004846 364.0
HKD2_k127_8035619_1 phosphorelay signal transduction system K07315 - 3.1.3.3 0.0000000000000000000000000000000001188 136.0
HKD2_k127_8035619_2 Histidine kinase - - - 0.0000000000000000000000000001519 123.0
HKD2_k127_8062191_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007548 578.0
HKD2_k127_8062191_1 Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003991 547.0
HKD2_k127_8062191_2 PFAM UBA THIF-type NAD FAD binding K21029 - 2.7.7.80 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007065 335.0
HKD2_k127_8062191_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 321.0
HKD2_k127_8062191_4 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001825 288.0
HKD2_k127_8062191_5 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001431 241.0
HKD2_k127_8062191_6 Tetratricopeptide repeats - - - 0.000000000000000000000000000000000000000000000000008297 205.0
HKD2_k127_8062191_7 proposed homoserine kinase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000001251 157.0
HKD2_k127_8078634_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 494.0
HKD2_k127_8078634_1 metal-dependent phosphohydrolase HD region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 317.0
HKD2_k127_8078634_2 Phage integrase, N-terminal SAM-like domain K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004347 305.0
HKD2_k127_8078634_3 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) K00564,K15460 - 2.1.1.172,2.1.1.223 0.0000000000000000000000000000000000000000000000000000000000000000000003347 245.0
HKD2_k127_8078634_4 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000003552 153.0
HKD2_k127_8082013_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.104e-216 680.0
HKD2_k127_8082013_1 Radical SAM superfamily K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 398.0
HKD2_k127_8082013_2 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 349.0
HKD2_k127_8100409_0 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 327.0
HKD2_k127_8100409_1 Transcriptional regulator K11921,K19338 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 309.0
HKD2_k127_8100409_2 Tetratricopeptide repeat K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000004901 239.0
HKD2_k127_8100409_3 Large-conductance mechanosensitive channel, MscL K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000000000000000000000000000000000000000000006387 228.0
HKD2_k127_8100409_4 OsmC-like protein K09136 - - 0.00000000000000000000000000000000000000000000006157 173.0
HKD2_k127_8100409_5 TIGRFAM siroheme synthase K02304 - 1.3.1.76,4.99.1.4 0.0000000000000000000000000000000000000000005256 166.0
HKD2_k127_8100409_6 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000002771 121.0
HKD2_k127_8128183_0 Conserved region in glutamate synthase - - - 3.363e-194 610.0
HKD2_k127_8128183_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 504.0
HKD2_k127_8128183_2 Ribonuclease R winged-helix domain K09720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007748 385.0
HKD2_k127_8128183_3 Dimerisation domain of Zinc Transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003488 274.0
HKD2_k127_8165170_0 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 440.0
HKD2_k127_8165170_1 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000003654 237.0
HKD2_k127_8165170_2 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.000000000000000000000000000000000000000000000007241 183.0
HKD2_k127_8165170_3 O-linked N-acetylglucosamine transferase SPINDLY family - - - 0.00000000000000000000000000000000000394 146.0
HKD2_k127_8171059_0 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002405 557.0
HKD2_k127_8171059_1 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000001204 228.0
HKD2_k127_8171059_2 PFAM pyridoxamine 5-phosphate - - - 0.000000000000000000000000000005569 121.0
HKD2_k127_8171059_3 Pyridoxamine 5'-phosphate oxidase - - - 0.00000000000000000000002057 105.0
HKD2_k127_8171059_4 Protein of unknown function (DUF1722) - - - 0.00000000000002418 72.0
HKD2_k127_8204232_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 7.031e-222 696.0
HKD2_k127_8204232_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005442 564.0
HKD2_k127_8204232_2 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000009373 234.0
HKD2_k127_8226033_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 4.353e-255 805.0
HKD2_k127_8226033_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 2.855e-221 702.0
HKD2_k127_8226033_2 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000009485 161.0
HKD2_k127_8232961_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 474.0
HKD2_k127_8232961_1 - - - - 0.0000002439 53.0
HKD2_k127_8232961_2 peptidase M48, Ste24p - - - 0.000002018 52.0
HKD2_k127_82912_0 Subtilase family K08651 - 3.4.21.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006135 379.0
HKD2_k127_82912_1 PFAM General secretion pathway protein K K02460 - - 0.00000000000000000000000000000000000008784 154.0
HKD2_k127_82912_2 General secretion pathway protein K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - 0.00000000000000000000000002712 117.0
HKD2_k127_82912_3 - - - - 0.00000000001228 74.0
HKD2_k127_82912_4 Prokaryotic N-terminal methylation motif K02458 - - 0.00000001793 61.0
HKD2_k127_829442_0 transposition, DNA-mediated - - - 0.000000000000000000000000000000000000000000000000006048 192.0
HKD2_k127_8320955_0 Branched-chain amino acid transport system / permease component K01997 GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015190,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015820,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0043090,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098713,GO:0098739,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007189 372.0
HKD2_k127_8320955_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001902 328.0
HKD2_k127_8320955_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001453 313.0
HKD2_k127_8344812_0 histidine kinase HAMP region domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 419.0
HKD2_k127_8344812_1 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 316.0
HKD2_k127_8360569_0 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.00000000000000000000000000000000000171 150.0
HKD2_k127_8360569_1 COG NOG19146 non supervised orthologous group - - - 0.0001291 46.0
HKD2_k127_8362537_0 GTP-binding protein TypA K06207 - - 4.173e-262 819.0
HKD2_k127_8362537_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 3.25e-206 654.0
HKD2_k127_8362537_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 607.0
HKD2_k127_8362537_3 ATPase kinase involved in NAD metabolism - - - 0.00000000000000000000000000000000000000000000000000000000000000000006864 239.0
HKD2_k127_8362537_4 PSP1 C-terminal conserved region - - - 0.000000000000000000000000000000000000000000000000000000000000000002552 236.0
HKD2_k127_8362537_5 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000001107 203.0
HKD2_k127_8362537_6 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000271 201.0
HKD2_k127_8362537_7 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000003425 209.0
HKD2_k127_8362537_8 PFAM Cupin 2, conserved barrel - - - 0.000000000000000000000000000000000000000001535 157.0
HKD2_k127_8362537_9 Protein of unknown function, DUF488 - - - 0.000000000000000000000000006658 111.0
HKD2_k127_83736_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005844 565.0
HKD2_k127_83736_1 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004485 487.0
HKD2_k127_83736_2 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 501.0
HKD2_k127_83736_3 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000002063 270.0
HKD2_k127_83736_4 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000000000000009648 205.0
HKD2_k127_83736_5 HAD-hyrolase-like K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000004449 205.0
HKD2_k127_83736_6 PFAM regulatory protein TetR K13770 - - 0.0000000000000000000000000000000000000258 151.0
HKD2_k127_83736_8 - - - - 0.0000000000000006217 85.0
HKD2_k127_83736_9 - - - - 0.000003537 50.0
HKD2_k127_8383881_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008714 411.0
HKD2_k127_8383881_1 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000002582 190.0
HKD2_k127_8383881_2 Protein of unknown function (DUF805) - - - 0.000000000000000002889 92.0
HKD2_k127_8406824_0 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006247 567.0
HKD2_k127_8406824_1 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007662 570.0
HKD2_k127_8406824_2 Pyridoxal-phosphate dependent enzyme K01738,K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 466.0
HKD2_k127_8406824_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008155 437.0
HKD2_k127_8406824_4 inositol monophosphate 1-phosphatase activity K01082,K01092 - 3.1.3.25,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000009464 236.0
HKD2_k127_8406824_5 Gaf domain K02488 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000004132 211.0
HKD2_k127_8406824_6 Histidine kinase A domain protein - - - 0.000000000000000000004004 109.0
HKD2_k127_8416618_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 490.0
HKD2_k127_8416618_1 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 303.0
HKD2_k127_8416618_2 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001082 274.0
HKD2_k127_8416618_3 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000002745 168.0
HKD2_k127_8504933_0 PFAM Nitrate reductase gamma subunit K00374 - 1.7.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 432.0
HKD2_k127_8504933_1 RsbT co-antagonist protein rsbRD N-terminal domain - - - 0.00000000000000000000000000000000000000000000005894 175.0
HKD2_k127_8564242_0 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008143 544.0
HKD2_k127_8564242_1 PFAM Radical SAM K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003943 527.0
HKD2_k127_8564242_10 proton-transporting ATP synthase activity, rotational mechanism K02115 - - 0.000000000000000000000000000000009382 138.0
HKD2_k127_8564242_11 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000000000000000000006835 122.0
HKD2_k127_8564242_12 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000007349 86.0
HKD2_k127_8564242_2 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006527 359.0
HKD2_k127_8564242_3 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K15022 - 1.17.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005629 321.0
HKD2_k127_8564242_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002523 271.0
HKD2_k127_8564242_5 GTP cyclohydrolase I K00950,K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659 2.7.6.3,3.5.4.16 0.000000000000000000000000000000000000000000000000000000000000000001702 232.0
HKD2_k127_8564242_6 GNAT family acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000383 218.0
HKD2_k127_8564242_7 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000007127 185.0
HKD2_k127_8564242_8 Glycoprotease family K01409,K14742 GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 0.0000000000000000000000000000000000000000000000002035 185.0
HKD2_k127_8564242_9 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000006724 157.0
HKD2_k127_8566364_0 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 515.0
HKD2_k127_8566364_1 Transcriptional regulator - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 374.0
HKD2_k127_8566364_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000005573 119.0
HKD2_k127_8606281_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000009184 272.0
HKD2_k127_8606281_1 Asparagine synthase K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000006119 172.0
HKD2_k127_8606281_2 Macrocin-O-methyltransferase (TylF) - - - 0.00000000000000000000000000000000001939 144.0
HKD2_k127_8606281_3 Methyltransferase domain - - - 0.0000000000000000000000000000000415 138.0
HKD2_k127_8606281_4 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.0000000000000000000002239 111.0
HKD2_k127_8606281_5 COG0500 SAM-dependent methyltransferases - - - 0.00000000000000000002701 102.0
HKD2_k127_8659408_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 2.866e-297 931.0
HKD2_k127_8659408_1 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 601.0
HKD2_k127_8659408_10 lactate metabolic process K11473,K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000002256 244.0
HKD2_k127_8659408_11 cyclic nucleotide binding K10914 - - 0.00000000000000000000000000000000000000000004584 166.0
HKD2_k127_8659408_13 deoxyhypusine monooxygenase activity - - - 0.0000000000000000000008934 104.0
HKD2_k127_8659408_14 Matrixin - - - 0.0000000000000000001455 102.0
HKD2_k127_8659408_15 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.0000000000000003601 91.0
HKD2_k127_8659408_16 cell envelope organization K05807,K08309 - - 0.00000000000000148 85.0
HKD2_k127_8659408_17 Regulatory protein, FmdB family - - - 0.000000000000001822 79.0
HKD2_k127_8659408_18 - - - - 0.000000007846 63.0
HKD2_k127_8659408_19 Papain family cysteine protease - - - 0.0000001585 63.0
HKD2_k127_8659408_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 534.0
HKD2_k127_8659408_3 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 525.0
HKD2_k127_8659408_4 Carbon-nitrogen hydrolase K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 518.0
HKD2_k127_8659408_5 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002889 409.0
HKD2_k127_8659408_6 Lysin motif K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001609 391.0
HKD2_k127_8659408_7 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005526 321.0
HKD2_k127_8659408_8 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001209 272.0
HKD2_k127_8659408_9 PFAM PP-loop domain protein K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000001056 243.0
HKD2_k127_8707244_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0 1141.0
HKD2_k127_8707244_1 Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 2.48e-219 682.0
HKD2_k127_8707244_2 GAF domain K02584 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 441.0
HKD2_k127_8736538_0 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004325 304.0
HKD2_k127_8736538_1 PFAM iron dependent repressor K03709 - - 0.00000000000000000000000000000000000000000000000005756 184.0
HKD2_k127_8736538_2 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.000000000000000000000000000000000000000000000001318 180.0
HKD2_k127_8736538_3 Protein conserved in bacteria - - - 0.000007411 49.0
HKD2_k127_8892007_0 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001134 280.0
HKD2_k127_8892007_1 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008042 264.0
HKD2_k127_8947034_0 Chemotaxis sensory transducer K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000018 233.0
HKD2_k127_8947034_1 protein-glutamate O-methyltransferase activity K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000001409 192.0
HKD2_k127_8947034_2 PFAM CheW domain protein K03408 - - 0.00000000000000000000000000000006457 133.0
HKD2_k127_8947034_3 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.1.61,3.5.1.44 0.000000000000000000148 91.0
HKD2_k127_8947034_4 PBS lyase HEAT domain protein repeat-containing protein - - - 0.000000002971 70.0
HKD2_k127_9033994_0 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 2.561e-212 662.0
HKD2_k127_9033994_1 endonuclease III K07457 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001151 259.0
HKD2_k127_9033994_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000001044 254.0
HKD2_k127_9037474_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000001285 213.0
HKD2_k127_9037474_1 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000005604 199.0
HKD2_k127_9037474_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000005604 199.0
HKD2_k127_9037474_3 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000000000000000000005016 173.0
HKD2_k127_9037474_4 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.0000000000000000000000000000000000000000000005419 169.0
HKD2_k127_9109230_0 Putative glycosyl hydrolase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 440.0
HKD2_k127_9109230_1 PFAM Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 323.0
HKD2_k127_9109230_2 Protein of unknown function (DUF520) K09767 - - 0.00000000000000000000000000000000006379 136.0
HKD2_k127_9111731_0 PAS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002465 289.0
HKD2_k127_9111731_1 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000000000000000000000000000000125 192.0
HKD2_k127_9111731_2 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000005318 198.0
HKD2_k127_9111731_3 Histidine kinase - - - 0.00000000000000000000000000001938 138.0
HKD2_k127_9111731_4 PhoQ Sensor - - - 0.00000000000000000000000000281 130.0
HKD2_k127_9111731_5 Metal-dependent phosphohydrolase - - - 0.00000000004232 64.0
HKD2_k127_9117525_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0 1321.0
HKD2_k127_9117525_1 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 5.958e-285 899.0
HKD2_k127_9117525_10 Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000638 155.0
HKD2_k127_9117525_11 sulfur carrier activity - GO:0008150,GO:0009987,GO:0019725,GO:0042592,GO:0048878,GO:0055082,GO:0065007,GO:0065008 - 0.00000000000000000000000000000000000000876 147.0
HKD2_k127_9117525_12 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000008283 134.0
HKD2_k127_9117525_13 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000000000000002645 123.0
HKD2_k127_9117525_14 AhpC/TSA family - - - 0.0000000000000000000009136 102.0
HKD2_k127_9117525_15 Domain of unknown function (DUF4136) - - - 0.0000000000000000001912 95.0
HKD2_k127_9117525_16 - - - - 0.0000000008333 64.0
HKD2_k127_9117525_17 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.0005679 45.0
HKD2_k127_9117525_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 5.417e-280 876.0
HKD2_k127_9117525_3 protein histidine kinase activity - - - 3.849e-211 673.0
HKD2_k127_9117525_4 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 548.0
HKD2_k127_9117525_5 SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006258 406.0
HKD2_k127_9117525_6 PFAM peptidase M16 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 381.0
HKD2_k127_9117525_7 Redoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003974 279.0
HKD2_k127_9117525_8 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000279 242.0
HKD2_k127_9117525_9 AhpC/TSA family - - - 0.0000000000000000000000000000000000000000000002118 174.0
HKD2_k127_9168055_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02652 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 575.0
HKD2_k127_9168055_1 Osmosensitive K+ channel His kinase sensor domain K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 546.0
HKD2_k127_9168055_10 Prokaryotic N-terminal methylation motif - - - 0.00000001873 62.0
HKD2_k127_9168055_11 TIGRFAM general secretion pathway protein H K02457 - - 0.00000002877 61.0
HKD2_k127_9168055_12 fimbrial assembly K02461 - - 0.00000008651 65.0
HKD2_k127_9168055_13 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.0000002632 52.0
HKD2_k127_9168055_2 sugar transferase K00996 - 2.7.8.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 438.0
HKD2_k127_9168055_3 Type II secretion system (T2SS), protein F K02455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 381.0
HKD2_k127_9168055_4 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008748 322.0
HKD2_k127_9168055_5 PFAM Glycosyl transferase family 2 K12992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004509 284.0
HKD2_k127_9168055_6 Type II secretion system (T2SS), protein K K02460 - - 0.0000000000000000000000000000000000000000000000000005748 196.0
HKD2_k127_9168055_7 Type II secretion system (T2SS), protein M subtype b - - - 0.00000000003291 71.0
HKD2_k127_9168055_8 Pfam:N_methyl_2 K02459 - - 0.0000000006925 69.0
HKD2_k127_9168055_9 PFAM Fimbrial assembly K02461 - - 0.000000009319 68.0
HKD2_k127_9233050_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 8.03e-268 835.0
HKD2_k127_9233050_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006901 445.0
HKD2_k127_9268335_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 5.894e-253 804.0
HKD2_k127_9268335_1 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 1.701e-203 639.0
HKD2_k127_9268335_10 Belongs to the Fur family K03711 - - 0.000000000000000000000000000008425 123.0
HKD2_k127_9268335_11 RDD family - - - 0.00000000000000000000001685 104.0
HKD2_k127_9268335_2 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 618.0
HKD2_k127_9268335_3 Actin K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005491 533.0
HKD2_k127_9268335_4 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 518.0
HKD2_k127_9268335_5 sulfate assimilation K00958 - 2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 368.0
HKD2_k127_9268335_6 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 357.0
HKD2_k127_9268335_7 DNA recombination-mediator protein A K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 310.0
HKD2_k127_9268335_8 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000002273 232.0
HKD2_k127_9268335_9 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000000005331 153.0
HKD2_k127_9291747_0 PFAM UbiA prenyltransferase K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004247 308.0
HKD2_k127_9291747_1 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000001589 206.0
HKD2_k127_9291747_2 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 0.00000000000000000000000000000000000000000000000000005217 188.0
HKD2_k127_9291747_3 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.000000000000000000000000000000000000000002177 159.0
HKD2_k127_9306050_0 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006794 456.0
HKD2_k127_9306050_1 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004291 291.0
HKD2_k127_9306050_2 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002326 285.0
HKD2_k127_9306050_3 Catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000004544 246.0
HKD2_k127_9324292_0 response regulator K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004468 482.0
HKD2_k127_9324292_1 Sensor histidine kinase PilS, PAS domain-containing K02668,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007879 321.0
HKD2_k127_9324292_2 Belongs to the LOG family K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 290.0
HKD2_k127_9324292_3 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000001668 191.0
HKD2_k127_9324292_4 nuclease K01174 GO:0003674,GO:0003824,GO:0004518,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901361,GO:1901575 3.1.31.1 0.000000000000000000000000000000000000000000004367 169.0
HKD2_k127_9324292_5 metalloendopeptidase activity K03799 - - 0.000000000000000000000000000000000003605 154.0
HKD2_k127_9324292_6 Type II secretion system (T2SS), protein F K02653 - - 0.000000000000000000000000000000006326 128.0
HKD2_k127_9324292_7 - - - - 0.00000000000002822 74.0
HKD2_k127_9338947_0 PFAM Outer membrane efflux protein K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 550.0
HKD2_k127_9338947_1 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 522.0
HKD2_k127_9338947_2 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008632 358.0
HKD2_k127_9338947_3 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000000000000000003571 199.0
HKD2_k127_9338947_4 Calcineurin-like phosphoesterase K07098 - - 0.000000000000000001707 87.0
HKD2_k127_941886_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 575.0
HKD2_k127_941886_1 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 364.0
HKD2_k127_941886_10 Domain of unknown function DUF11 - - - 0.0000179 53.0
HKD2_k127_941886_2 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004632 351.0
HKD2_k127_941886_3 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 346.0
HKD2_k127_941886_4 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000000000000000000000000000002047 234.0
HKD2_k127_941886_5 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000000000000000000000000000000001068 192.0
HKD2_k127_941886_6 - - - - 0.000000000000000000000000000000000000000005938 161.0
HKD2_k127_941886_7 Type IV pilus biogenesis stability protein PilW - - - 0.000000000000000000000000000000000006084 142.0
HKD2_k127_941886_8 COG2365 Protein tyrosine serine phosphatase - - - 0.000000000000000000000003251 117.0
HKD2_k127_941886_9 - - - - 0.000000004709 69.0
HKD2_k127_9422417_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 1.176e-281 876.0
HKD2_k127_9422417_1 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006085 345.0
HKD2_k127_9422417_2 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003676 334.0
HKD2_k127_9422417_3 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004053 318.0
HKD2_k127_9422417_4 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000000000000000000001918 214.0
HKD2_k127_9422417_5 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000004202 191.0
HKD2_k127_9422417_6 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000006064 190.0
HKD2_k127_9422417_7 Threonyl-tRNA synthetase - - - 0.0000000000000000000000000000000000000001505 154.0
HKD2_k127_9422417_8 Sporulation and spore germination - - - 0.000000000000000001071 93.0
HKD2_k127_9422417_9 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.00000000001412 76.0
HKD2_k127_9445929_0 Pyruvate:ferredoxin oxidoreductase core domain II K00169 - 1.2.7.1 1.764e-207 650.0
HKD2_k127_9445929_1 NADH flavin oxidoreductase NADH oxidase K10680 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 587.0
HKD2_k127_9445929_10 Domain of unknown function (DUF1732) - - - 0.00000000000000000000000000000000000000000000000000000000007799 214.0
HKD2_k127_9445929_11 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00171,K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000001884 171.0
HKD2_k127_9445929_12 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000001745 171.0
HKD2_k127_9445929_13 COG0666 FOG Ankyrin repeat K06867 - - 0.000000000000000000000000000007115 132.0
HKD2_k127_9445929_14 Domain of unknown function (DUF370) K09777 - - 0.00000000000000000000000000002927 119.0
HKD2_k127_9445929_15 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000000000000000000005539 116.0
HKD2_k127_9445929_16 Hemerythrin HHE cation binding domain K07216 - - 0.0000000000000000000002871 102.0
HKD2_k127_9445929_17 Roadblock/LC7 domain - - - 0.000000000000000000004658 97.0
HKD2_k127_9445929_18 belongs to the thioredoxin family K14949,K20543 - 2.7.11.1 0.00000000000000001778 94.0
HKD2_k127_9445929_19 Putative zinc- or iron-chelating domain K09160 - - 0.000002079 55.0
HKD2_k127_9445929_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 518.0
HKD2_k127_9445929_3 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 394.0
HKD2_k127_9445929_4 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 321.0
HKD2_k127_9445929_5 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 322.0
HKD2_k127_9445929_6 Creatinase Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007969 316.0
HKD2_k127_9445929_7 Pyruvate ferredoxin/flavodoxin oxidoreductase K00172 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003913 300.0
HKD2_k127_9445929_8 PFAM Roadblock LC7 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000009432 216.0
HKD2_k127_9445929_9 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000002783 212.0
HKD2_k127_9450665_0 PFAM 2-nitropropane dioxygenase NPD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 509.0
HKD2_k127_9450665_1 Belongs to the ABC transporter superfamily K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 359.0
HKD2_k127_9450665_2 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 352.0
HKD2_k127_9450665_3 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000002609 264.0
HKD2_k127_9450665_4 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000009453 203.0
HKD2_k127_9450665_5 dna ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000001297 186.0
HKD2_k127_9450665_6 TPR repeat - - - 0.0000000000000000000000000000000000000000000000001388 184.0
HKD2_k127_9450665_7 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000000000126 103.0
HKD2_k127_9451039_0 PFAM peptidase M24 K01262,K01271 - 3.4.11.9,3.4.13.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 493.0
HKD2_k127_9451039_1 Protein of unknown function (DUF512) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 458.0
HKD2_k127_9451039_10 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.00000000000000000315 94.0
HKD2_k127_9451039_11 PFAM PBS lyase HEAT-like repeat - - - 0.000000000001713 74.0
HKD2_k127_9451039_13 Serine threonine protein kinase K08884,K12132 GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 0.000000004275 66.0
HKD2_k127_9451039_14 - - - - 0.00000003292 60.0
HKD2_k127_9451039_2 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009891 381.0
HKD2_k127_9451039_3 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 300.0
HKD2_k127_9451039_4 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003457 278.0
HKD2_k127_9451039_5 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000000000000006379 218.0
HKD2_k127_9451039_6 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.0000000000000000000000000000000000000000007028 165.0
HKD2_k127_9451039_7 Domain of unknown function (DUF1992) - - - 0.00000000000000000000000000000000000000001204 156.0
HKD2_k127_9451039_8 CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.00000000000000000000000000000002002 133.0
HKD2_k127_9451039_9 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000229 127.0
HKD2_k127_947029_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00436,K14126 - 1.12.1.2,1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 424.0
HKD2_k127_947029_1 Sulfurtransferase TusA - - - 0.00000000000000000000000000785 111.0
HKD2_k127_947029_2 histidine kinase HAMP region domain protein K03406 - - 0.0000000000000000001184 102.0
HKD2_k127_9486292_0 Receptor family ligand binding region K01999 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 407.0
HKD2_k127_9486292_1 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 366.0
HKD2_k127_9486292_2 Nitroreductase family K04719 - 1.13.11.79 0.000000000000000000000000000000000000000000000000000000000002309 213.0
HKD2_k127_9486292_3 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000002269 106.0
HKD2_k127_952595_0 Belongs to the glycosyl hydrolase 57 family - - - 0.0 1067.0
HKD2_k127_952595_1 alpha amylase, catalytic K01236 - 3.2.1.141 8.579e-236 745.0
HKD2_k127_952595_2 PFAM Glycosyl transferases group 1 K13057 - 2.4.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005237 601.0
HKD2_k127_952595_3 Alpha amylase, catalytic domain K06044 - 5.4.99.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000001098 296.0
HKD2_k127_957472_0 Probable RNA and SrmB- binding site of polymerase A K00974 - 2.7.7.72 4.221e-276 873.0
HKD2_k127_957472_1 DNA polymerase K02347 - - 1.156e-228 722.0
HKD2_k127_957472_10 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 389.0
HKD2_k127_957472_11 Cell cycle protein K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002319 387.0
HKD2_k127_957472_12 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004796 357.0
HKD2_k127_957472_13 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002132 326.0
HKD2_k127_957472_14 diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000014 288.0
HKD2_k127_957472_15 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000002752 262.0
HKD2_k127_957472_16 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000148 229.0
HKD2_k127_957472_17 MraZ protein, putative antitoxin-like K03925 - - 0.00000000000000000000000000000000000000000000000000000008794 198.0
HKD2_k127_957472_18 PFAM response regulator receiver K02030 - - 0.000000000000000000000000000000000000000002151 171.0
HKD2_k127_957472_19 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000001377 128.0
HKD2_k127_957472_2 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 593.0
HKD2_k127_957472_20 Putative peptidoglycan binding domain - - - 0.00000000000000007083 87.0
HKD2_k127_957472_21 Stringent starvation protein B K09985 - - 0.000000000000001657 81.0
HKD2_k127_957472_23 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - 0.00000003059 64.0
HKD2_k127_957472_3 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002544 544.0
HKD2_k127_957472_4 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007618 517.0
HKD2_k127_957472_5 acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006524 473.0
HKD2_k127_957472_6 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 441.0
HKD2_k127_957472_7 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 416.0
HKD2_k127_957472_8 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 399.0
HKD2_k127_957472_9 Cell wall formation K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 385.0
HKD2_k127_9674078_0 Large extracellular alpha-helical protein K06894 - - 0.0 2012.0
HKD2_k127_9674078_1 Penicillin-Binding Protein C-terminus Family K05367 - 2.4.1.129 8.467e-221 706.0
HKD2_k127_9674078_2 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000000000001228 229.0
HKD2_k127_9693865_0 Endoribonuclease that initiates mRNA decay K18682 - - 4.546e-213 674.0
HKD2_k127_9693865_1 YmdB-like protein K09769 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009646 354.0
HKD2_k127_9693865_2 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000008014 241.0
HKD2_k127_9693865_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000001053 155.0
HKD2_k127_9693865_4 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00007671 46.0
HKD2_k127_9696753_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0 1165.0
HKD2_k127_9696753_1 Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 2.374e-313 967.0
HKD2_k127_9696753_10 Hydrogenase 4 membrane K12140 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001976 250.0
HKD2_k127_9696753_11 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009379 240.0
HKD2_k127_9696753_12 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000005092 72.0
HKD2_k127_9696753_2 Proton-conducting membrane transporter - - - 8.268e-258 810.0
HKD2_k127_9696753_3 Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - - 3.67e-225 708.0
HKD2_k127_9696753_4 GAF domain K02584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 555.0
HKD2_k127_9696753_5 Proton-conducting membrane transporter K12141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004646 501.0
HKD2_k127_9696753_6 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 422.0
HKD2_k127_9696753_7 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001843 320.0
HKD2_k127_9696753_8 PFAM Glutamine amidotransferase, class-II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008797 287.0
HKD2_k127_9696753_9 Macrocin-O-methyltransferase (TylF) K05303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000145 267.0
HKD2_k127_9725152_0 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 538.0
HKD2_k127_9725152_1 May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins K13819 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 363.0
HKD2_k127_9725152_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 285.0
HKD2_k127_9725152_3 Zinc dependent phospholipase C - - - 0.000000000000000000000000000000000000000000000221 180.0
HKD2_k127_9725152_4 GYD domain - - - 0.0000000000000000000000000000000001689 137.0
HKD2_k127_9725152_5 - - - - 0.0000000000001459 74.0
HKD2_k127_9725152_6 Collagen triple helix repeat (20 copies) - - - 0.000000005393 64.0
HKD2_k127_9786809_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 569.0
HKD2_k127_9786809_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005777 494.0
HKD2_k127_9786809_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 383.0
HKD2_k127_9786809_3 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 300.0
HKD2_k127_9786809_4 PASTA K12132 - 2.7.11.1 0.000000000009486 74.0
HKD2_k127_9786809_6 - - - - 0.0005459 48.0
HKD2_k127_9789711_0 Transport of potassium into the cell K03549 - - 2.625e-247 776.0
HKD2_k127_9789711_1 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 570.0
HKD2_k127_9789711_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003578 270.0
HKD2_k127_9789711_3 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 0.0000000000000000000000000000000000000000000000000000000000000000009328 239.0
HKD2_k127_9789711_4 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000001774 185.0
HKD2_k127_9789711_5 Peptidase family M23 - - - 0.000000000000000000000000001394 117.0
HKD2_k127_9789711_6 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000205 112.0
HKD2_k127_9823202_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001799 338.0
HKD2_k127_9823202_1 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.000000000000000000000000000000000000000000000000000007316 197.0
HKD2_k127_9823202_2 Outer membrane lipoprotein - - - 0.0000000000000000000000000000000000003594 154.0
HKD2_k127_9823202_3 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000003964 147.0
HKD2_k127_9844714_0 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006735 351.0
HKD2_k127_9844714_1 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000002947 266.0
HKD2_k127_9844714_2 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.00000000000000000000000000000588 128.0
HKD2_k127_9844714_3 Fimbrial assembly protein (PilN) K02663 - - 0.0000005024 59.0
HKD2_k127_9847338_0 Beta-Casp domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 572.0
HKD2_k127_9847338_1 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 547.0
HKD2_k127_9847338_11 Nitroreductase family - - - 0.0000000000001855 72.0
HKD2_k127_9847338_2 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002196 466.0
HKD2_k127_9847338_3 HELICc2 K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008709 369.0
HKD2_k127_9847338_4 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.000000000000000000000000000000000000000000000001834 176.0
HKD2_k127_9847338_5 lysyltransferase activity K07027 - - 0.000000000000000000000000000000000000000002122 167.0
HKD2_k127_9847338_6 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000000000000000009757 154.0
HKD2_k127_9847338_7 Protein of unknown function (DUF1284) K09706 - - 0.0000000000000000000000000000000000004828 143.0
HKD2_k127_9847338_8 phosphohistidine phosphatase, SixA K03574,K08296 - 3.6.1.55 0.000000000000000000000000000000000001426 144.0
HKD2_k127_9847338_9 GDP-mannose mannosyl hydrolase activity - - - 0.000000000000000000000111 100.0
HKD2_k127_9866581_0 Carbohydrate phosphorylase K00688 - 2.4.1.1 9.396e-314 980.0
HKD2_k127_9866581_1 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007125 530.0
HKD2_k127_9866581_2 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004034 406.0
HKD2_k127_9866581_3 Cytokinin riboside 5'-monophosphate phosphoribohydrolase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 356.0
HKD2_k127_9866581_4 HNH nucleases - - - 0.000000000000000000000000000000000000000004646 160.0
HKD2_k127_9866581_5 regulation of translation K03530 - - 0.0000000000000000000000000000000002997 133.0
HKD2_k127_9866581_6 Domain of unknown function (DUF4388) - - - 0.000000000000000000002104 96.0
HKD2_k127_9866581_7 Histidine kinase K07708,K07710 GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.13.3 0.000000000000000009432 96.0
HKD2_k127_9866581_8 Putative zinc- or iron-chelating domain - - - 0.00000000000000003062 87.0
HKD2_k127_9916376_0 amine dehydrogenase activity - - - 0.000000000000000000000000000000000004589 139.0
HKD2_k127_9916376_1 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.0000000000000000000000000000000005695 140.0
HKD2_k127_9916376_2 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000002335 128.0
HKD2_k127_9928752_0 helix_turn_helix gluconate operon transcriptional repressor K03710 - - 0.000000000000000000000000000000000000000000000000000000000000000000002464 241.0
HKD2_k127_9928752_1 response regulator - - - 0.00000000000000000000000000000000000000000000000000000002194 203.0
HKD2_k127_9928752_2 Histidine kinase - - - 0.0000000000000000000000000000000003137 145.0
HKD2_k127_9928752_3 beta-galactosidase activity - - - 0.00000000000000000000000008682 116.0
HKD2_k127_996859_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 2.125e-286 883.0
HKD2_k127_996859_1 Bacterial protein of unknown function (DUF853) - - - 9.93e-215 677.0
HKD2_k127_996859_2 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 381.0
HKD2_k127_996859_3 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000000000000000000000005069 223.0
HKD2_k127_996859_4 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000001864 121.0