Overview

ID MAG01784
Name HKD2_bin.26
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Patescibacteriota
Class Microgenomatia
Order GWA2-44-7
Family Amesbacteraceae
Genus XYB1-FULL-44-23
Species
Assembly information
Completeness (%) 82.81
Contamination (%) 0.1
GC content (%) 48.0
N50 (bp) 18,701
Genome size (bp) 803,467

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes666

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_1157454_0 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000000000000000000000000000001125 164.0
HKD2_k127_1157454_1 Polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000004793 166.0
HKD2_k127_1157454_2 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases K02503 - - 0.000000000000000001629 91.0
HKD2_k127_1157454_3 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000004233 82.0
HKD2_k127_1157454_4 PFAM blue (type 1) copper domain protein - - - 0.000004995 55.0
HKD2_k127_140250_0 Protein of unknown function (DUF4256) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 290.0
HKD2_k127_140250_1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.000000000000000000006963 103.0
HKD2_k127_140250_2 NUDIX domain - - - 0.0000000006788 70.0
HKD2_k127_1543545_0 Alpha-2-macroglobulin family K06894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 412.0
HKD2_k127_1543545_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000001072 191.0
HKD2_k127_1543545_2 Bacterial capsule synthesis protein PGA_cap K07282,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000001697 186.0
HKD2_k127_1543545_3 Memo-like protein K06990,K07282 - - 0.00000000000000006135 92.0
HKD2_k127_1543545_4 Hep Hag repeat protein - - - 0.000000000001376 82.0
HKD2_k127_1543545_5 - - - - 0.0000000004664 69.0
HKD2_k127_1543545_6 PFAM CBS domain containing protein K04767 - - 0.000000009053 58.0
HKD2_k127_168437_0 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 434.0
HKD2_k127_168437_1 PFAM amine oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 375.0
HKD2_k127_168437_10 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000005106 149.0
HKD2_k127_168437_11 Mannosyltransferase (PIG-V) - - - 0.00000000000000000000000000000000002331 150.0
HKD2_k127_168437_12 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000007553 132.0
HKD2_k127_168437_13 involved in cell wall biogenesis - - - 0.0000000000000000000000000004423 122.0
HKD2_k127_168437_14 Alpha-L-fucosidase - - - 0.000000000000000000000000002067 129.0
HKD2_k127_168437_15 Methyltransferase type 11 - - - 0.00000000000000008021 90.0
HKD2_k127_168437_16 glycosyl transferase family - - - 0.0000000000000002844 92.0
HKD2_k127_168437_17 COG0500 SAM-dependent methyltransferases K03183 - 2.1.1.163,2.1.1.201 0.00000000000001021 83.0
HKD2_k127_168437_18 Methionine biosynthesis protein MetW - - - 0.00000000001546 74.0
HKD2_k127_168437_19 polysaccharide biosynthetic process - - - 0.00000000245 69.0
HKD2_k127_168437_2 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009493 284.0
HKD2_k127_168437_20 Psort location CytoplasmicMembrane, score K00368,K07233,K22349 - 1.16.3.3,1.7.2.1 0.00000358 57.0
HKD2_k127_168437_21 - - - - 0.000006482 58.0
HKD2_k127_168437_22 Methyltransferase domain - - - 0.00007684 52.0
HKD2_k127_168437_23 - - - - 0.0004474 52.0
HKD2_k127_168437_3 PFAM glycosyl transferase family 39 - - - 0.0000000000000000000000000000000000000000000000000000006369 213.0
HKD2_k127_168437_4 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000005278 186.0
HKD2_k127_168437_5 PFAM glycosyl transferase family 39 - - - 0.00000000000000000000000000000000000000000000002693 189.0
HKD2_k127_168437_6 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000005707 178.0
HKD2_k127_168437_7 Glycosyl transferase family 2 K12984 - - 0.0000000000000000000000000000000000000000000001424 178.0
HKD2_k127_168437_8 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000005849 160.0
HKD2_k127_1887310_0 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000003692 254.0
HKD2_k127_1887310_1 Protein-disulfide isomerase - - - 0.00000000000000000000000000000001103 139.0
HKD2_k127_1887310_2 RNA methyltransferase TrmH family - - - 0.000000000000000000000002101 109.0
HKD2_k127_1887310_3 - - - - 0.0000000000000002151 82.0
HKD2_k127_1887310_5 - - - - 0.000000003048 65.0
HKD2_k127_1887310_6 - - - - 0.00000001079 58.0
HKD2_k127_1887310_8 GBS Bsp-like repeat - - - 0.0001401 54.0
HKD2_k127_2010708_0 PFAM ErfK YbiS YcfS YnhG family protein - - - 0.0000000000000000000000000008651 123.0
HKD2_k127_2010708_1 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000002797 71.0
HKD2_k127_2010708_2 RTX toxins and related Ca2 binding proteins - - - 0.00003431 55.0
HKD2_k127_2010708_3 Type II secretion system protein G K02456 - - 0.0003437 49.0
HKD2_k127_2010708_4 - - - - 0.0004608 48.0
HKD2_k127_2010708_5 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0006879 45.0
HKD2_k127_2014291_0 Glycosyltransferases, probably involved in cell wall biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000075 452.0
HKD2_k127_2014291_1 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000008832 258.0
HKD2_k127_2014291_10 VanZ like family - - - 0.00000000000000002313 89.0
HKD2_k127_2014291_11 Peptidase family M23 K21471 - - 0.000000000009004 76.0
HKD2_k127_2014291_2 cell division ATP-binding protein FtsE K09812 GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0007049,GO:0008150,GO:0008356,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0032506,GO:0042173,GO:0043937,GO:0043938,GO:0044085,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:1902531 - 0.0000000000000000000000000000000000000000000000000000000000000006715 226.0
HKD2_k127_2014291_3 A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics - - - 0.000000000000000000000000000000000000000000000000007476 190.0
HKD2_k127_2014291_4 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000001449 176.0
HKD2_k127_2014291_5 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000006485 169.0
HKD2_k127_2014291_6 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000001084 130.0
HKD2_k127_2014291_7 Psort location Cytoplasmic, score 9.65 - - - 0.00000000000000000000000000271 117.0
HKD2_k127_2014291_8 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation K09811 - - 0.0000000000000000000000003251 116.0
HKD2_k127_2014291_9 PFAM Glycosyl transferase family 2 K07011,K11936 - - 0.000000000000000000005258 104.0
HKD2_k127_2156658_0 PFAM Fructose-bisphosphate aldolase, class-I K01623 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 372.0
HKD2_k127_2156658_1 Transketolase, pyrimidine binding domain - - - 0.0000000000000000000000000000000000000000001329 162.0
HKD2_k127_2156658_2 COG COG2367 Beta-lactamase class A Defense mechanisms K17836 - 3.5.2.6 0.00000000000000000000000006975 119.0
HKD2_k127_2156658_3 pfkB family carbohydrate kinase K00852 - 2.7.1.15 0.0000000000000000000003619 108.0
HKD2_k127_2156658_4 Glycosyl Transferase K19002 - 2.4.1.337 0.00000000000000003246 85.0
HKD2_k127_2156658_5 metallopeptidase activity - - - 0.0000001064 58.0
HKD2_k127_2156658_6 HAD-hyrolase-like K07025 - - 0.000007716 56.0
HKD2_k127_2276454_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567,K04568 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004308 494.0
HKD2_k127_2276454_1 seryl-tRNA aminoacylation K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 462.0
HKD2_k127_2276454_2 Metal dependent phosphohydrolases with conserved 'HD' motif. K06951 - - 0.000000000000000000000000000000000000000000000001704 179.0
HKD2_k127_2276454_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - 0.00000000000000000000000000000004752 130.0
HKD2_k127_2276454_4 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.00000000000000000000000000000008649 132.0
HKD2_k127_2276454_5 Belongs to the phosphoglycerate mutase family K22305 - 3.1.3.3 0.00000000000000000000000000228 119.0
HKD2_k127_2276454_6 COGs COG1132 ABC-type multidrug transport system ATPase and permease components K06147 - - 0.0004221 50.0
HKD2_k127_2294627_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006607 526.0
HKD2_k127_2294627_1 Type IV secretory pathway, VirB4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000737 410.0
HKD2_k127_2294627_11 Lipid A core - O-antigen ligase and related enzymes - - - 0.0003029 53.0
HKD2_k127_2294627_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004215 319.0
HKD2_k127_2294627_3 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000007003 239.0
HKD2_k127_2294627_4 PFAM 60 kDa inner membrane insertion protein K03217 - - 0.000000000000000000000000000000000000000008681 164.0
HKD2_k127_2294627_5 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000001974 117.0
HKD2_k127_2294627_6 R3H domain protein K06346 - - 0.0000000000000000000005382 101.0
HKD2_k127_2294627_7 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000001734 89.0
HKD2_k127_2294627_8 Reverse transcriptase-like - - - 0.0000000000000000002261 93.0
HKD2_k127_2294627_9 Ribosomal protein L34 K02914 - - 0.00000001092 58.0
HKD2_k127_2352533_0 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008617 265.0
HKD2_k127_2352533_1 - - - - 0.0000000000000000000000000000000000000000000000000000005577 196.0
HKD2_k127_2352533_2 NUDIX domain K01515 - 3.6.1.13 0.000000000000000000000000000007834 125.0
HKD2_k127_2352533_3 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.000000000000000000002203 106.0
HKD2_k127_2352533_4 spore germination K08978 - - 0.00000000004751 73.0
HKD2_k127_2352533_5 Belongs to the UPF0235 family K09131 - - 0.0000000003464 63.0
HKD2_k127_2581242_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000762 310.0
HKD2_k127_2581242_1 impB/mucB/samB family C-terminal domain K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000003401 242.0
HKD2_k127_2581242_10 DNA polymerase family B, exonuclease domain K07501 - - 0.0000000000000000000000000000002769 131.0
HKD2_k127_2581242_11 Zincin-like metallopeptidase - - - 0.0000000000000000000000000003641 118.0
HKD2_k127_2581242_12 Glycosyl transferase K00728 - 2.4.1.109 0.000000000000000009075 96.0
HKD2_k127_2581242_13 spore germination K08978 - - 0.000000000000000145 91.0
HKD2_k127_2581242_14 Psort location CytoplasmicMembrane, score - - - 0.00000000000008827 81.0
HKD2_k127_2581242_15 Glycosyltransferase family 87 - - - 0.0001029 54.0
HKD2_k127_2581242_16 - - - - 0.0001171 48.0
HKD2_k127_2581242_17 FR47-like protein - - - 0.0002769 49.0
HKD2_k127_2581242_2 peptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000001754 227.0
HKD2_k127_2581242_3 Aminoglycoside-2''-adenylyltransferase K19545 - - 0.0000000000000000000000000000000000000000000000000000002114 200.0
HKD2_k127_2581242_4 glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000000000000000000000000004314 195.0
HKD2_k127_2581242_5 Peptide-methionine (R)-S-oxide reductase K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000719 180.0
HKD2_k127_2581242_7 glycosyl transferase, family 39 - - - 0.000000000000000000000000000000000000008111 164.0
HKD2_k127_2581242_8 Glycosyl transferase, family 2 K07011 - - 0.0000000000000000000000000000000000003221 151.0
HKD2_k127_2581242_9 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000001056 148.0
HKD2_k127_277010_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007584 554.0
HKD2_k127_277010_1 Penicillin-binding Protein dimerisation domain K03587,K08384 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 368.0
HKD2_k127_277010_2 TIGRFAM stage V sporulation protein E, cell division protein FtsW K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000241 277.0
HKD2_k127_277010_3 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000004699 255.0
HKD2_k127_277010_4 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000004176 159.0
HKD2_k127_277010_5 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000005881 148.0
HKD2_k127_277010_6 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000001833 152.0
HKD2_k127_277010_7 Diacylglycerol kinase K00887,K00901 - 2.7.1.107,2.7.1.66 0.0000000000000000000000005479 109.0
HKD2_k127_277010_8 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0098552,GO:0098562 - 0.00000001144 58.0
HKD2_k127_277010_9 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00006113 49.0
HKD2_k127_293611_0 PFAM PHP domain - - - 0.00000000000000000000000000319 120.0
HKD2_k127_293611_1 Catalyzes the formation of CDP-2,3-bis-(O- geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O- geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids K19664 - 2.7.7.67 0.000000000000000000000003061 110.0
HKD2_k127_293611_3 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0003623 51.0
HKD2_k127_293611_4 Prokaryotic N-terminal methylation motif - - - 0.0007961 48.0
HKD2_k127_3108525_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 8.557e-206 653.0
HKD2_k127_3108525_1 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006498 357.0
HKD2_k127_3108525_10 Hydrolase, P-loop family K06925 - - 0.000000000002298 78.0
HKD2_k127_3108525_11 UbiA prenyltransferase family - - - 0.000000008318 59.0
HKD2_k127_3108525_12 nucleotidyltransferase activity - - - 0.00000002493 65.0
HKD2_k127_3108525_15 Ami_3 K01448 GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.5.1.28 0.0007129 51.0
HKD2_k127_3108525_2 PFAM VanW family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001286 284.0
HKD2_k127_3108525_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000001469 235.0
HKD2_k127_3108525_4 PFAM HhH-GPD superfamily base excision DNA repair protein K01247 - 3.2.2.21 0.00000000000000000000000000000000000005198 151.0
HKD2_k127_3108525_5 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0000000000000000000000000000000008696 134.0
HKD2_k127_3108525_6 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000002288 124.0
HKD2_k127_3108525_7 PFAM Peptidase family M23 - - - 0.0000000000000000000000005071 114.0
HKD2_k127_3108525_8 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000002291 92.0
HKD2_k127_3108525_9 Bacterial extracellular solute-binding protein K02027 - - 0.000000000000004359 88.0
HKD2_k127_3249760_0 TIGRFAM FeS assembly protein SufB K07033,K09014 - - 2.195e-213 671.0
HKD2_k127_3249760_1 Acyl-CoA synthetase (NDP forming) K09181 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 499.0
HKD2_k127_3249760_10 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress - - - 0.0000000000000000000000000000000000006924 148.0
HKD2_k127_3249760_11 NifU-like N terminal domain K04488 - - 0.00000000000000000000000000004218 120.0
HKD2_k127_3249760_12 - - - - 0.000000000000000000000002936 108.0
HKD2_k127_3249760_13 FeS assembly protein SufD K07033,K09015 - - 0.0000000000000000000002372 104.0
HKD2_k127_3249760_14 Mannosyltransferase (PIG-V) - - - 0.000000000000001745 89.0
HKD2_k127_3249760_15 - - - - 0.000000000000006221 84.0
HKD2_k127_3249760_16 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.000000001543 61.0
HKD2_k127_3249760_17 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000217 65.0
HKD2_k127_3249760_18 4Fe-4S single cluster domain K05337 - - 0.00000001106 59.0
HKD2_k127_3249760_19 Endonuclease Exonuclease Phosphatase - - - 0.0000000112 68.0
HKD2_k127_3249760_2 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 433.0
HKD2_k127_3249760_20 PFAM SMP-30 Gluconolaconase - - - 0.000008758 59.0
HKD2_k127_3249760_3 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006006 380.0
HKD2_k127_3249760_4 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008454 283.0
HKD2_k127_3249760_5 ABC transporter K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000647 256.0
HKD2_k127_3249760_6 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000008891 245.0
HKD2_k127_3249760_7 Nickel-dependent hydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000003311 251.0
HKD2_k127_3249760_8 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000001793 188.0
HKD2_k127_3511080_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000744 596.0
HKD2_k127_3511080_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 534.0
HKD2_k127_3511080_10 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 0.000000000000000000000000000000000000000000000000000009683 197.0
HKD2_k127_3511080_11 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000009238 196.0
HKD2_k127_3511080_12 GDP-mannose-dependent alpha-(1-2)-phosphatidylinositol mannosyltransferase K08256 GO:0000026,GO:0000030,GO:0000287,GO:0003674,GO:0003824,GO:0004376,GO:0004377,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0043167,GO:0043169,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046486,GO:0046488,GO:0046872,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.345 0.00000000000000000000000000000000000000000000001723 185.0
HKD2_k127_3511080_13 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000008344 168.0
HKD2_k127_3511080_14 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000001777 158.0
HKD2_k127_3511080_15 SpoVT / AbrB like domain - - - 0.000000000000000000000000000000218 136.0
HKD2_k127_3511080_16 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000002707 123.0
HKD2_k127_3511080_17 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000002865 121.0
HKD2_k127_3511080_18 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000002315 107.0
HKD2_k127_3511080_19 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000005913 97.0
HKD2_k127_3511080_2 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006978 416.0
HKD2_k127_3511080_20 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000002549 83.0
HKD2_k127_3511080_21 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000005287 88.0
HKD2_k127_3511080_22 DHHA1 domain protein K06881 - 3.1.13.3,3.1.3.7 0.0000000000002657 81.0
HKD2_k127_3511080_23 ASCH - - - 0.00000002488 61.0
HKD2_k127_3511080_24 protein of Bacteria UniRef RepID - - - 0.0000001266 63.0
HKD2_k127_3511080_25 ATP synthase F(0) sector subunit b K02109 - - 0.00000918 54.0
HKD2_k127_3511080_26 glycosyl transferase group 1 - - - 0.00002168 54.0
HKD2_k127_3511080_27 carbonate dehydratase activity K01673 - 4.2.1.1 0.00006777 50.0
HKD2_k127_3511080_28 TM2 domain - - - 0.0001122 49.0
HKD2_k127_3511080_29 MFS general substrate transporter - - - 0.0003958 52.0
HKD2_k127_3511080_3 FAD dependent oxidoreductase K07137 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 377.0
HKD2_k127_3511080_4 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 300.0
HKD2_k127_3511080_5 PFAM metal-dependent phosphohydrolase HD sub domain K09163 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001226 266.0
HKD2_k127_3511080_6 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000005238 248.0
HKD2_k127_3511080_7 Fic/DOC family N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000005256 248.0
HKD2_k127_3511080_8 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000004911 203.0
HKD2_k127_3511080_9 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000789 200.0
HKD2_k127_3614923_0 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005903 286.0
HKD2_k127_3614923_1 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000005189 268.0
HKD2_k127_3614923_2 undecaprenyl-phosphate glucose phosphotransferase activity - - - 0.00000000000000000000000000000000000000000000000000001063 196.0
HKD2_k127_3614923_3 Methylpurine-DNA glycosylase (MPG) K03652 GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 0.000000000000000000000000000000000000000000000001568 181.0
HKD2_k127_3614923_4 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000006566 166.0
HKD2_k127_3614923_5 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.0000000000000000000000000000000000006328 160.0
HKD2_k127_3614923_6 glycosyl transferase family 2 K07011 - - 0.0000000000000000000003099 102.0
HKD2_k127_3614923_7 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000004155 54.0
HKD2_k127_3944193_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000002011 211.0
HKD2_k127_3944193_1 - - - - 0.0000000000000000000000000000000000000000000000000000006524 212.0
HKD2_k127_3944193_10 23S rRNA-intervening sequence protein - - - 0.0000114 52.0
HKD2_k127_3944193_11 PFAM O-antigen polymerase K18814 - - 0.0000129 58.0
HKD2_k127_3944193_2 Ham1 family - - - 0.0000000000000000000000000000000000000000000000002796 183.0
HKD2_k127_3944193_3 Peptidase family M50 - - - 0.000000000000000000000000000000000001849 151.0
HKD2_k127_3944193_4 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000006923 142.0
HKD2_k127_3944193_5 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.00000000000000000000000000001291 125.0
HKD2_k127_3944193_6 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000003419 111.0
HKD2_k127_3944193_7 CYTH domain - - - 0.000000000000000000003744 100.0
HKD2_k127_3944193_8 Thymidylate synthase K00560 - 2.1.1.45 0.00000000009958 71.0
HKD2_k127_3944193_9 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0071944 - 0.0000006521 58.0
HKD2_k127_3948271_0 ABC transporter K06147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002176 367.0
HKD2_k127_3948271_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000137 274.0
HKD2_k127_4080196_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 321.0
HKD2_k127_4080196_1 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007101 312.0
HKD2_k127_4080196_10 Transcription factor zinc-finger K09981 - - 0.0007856 50.0
HKD2_k127_4080196_2 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000004232 202.0
HKD2_k127_4080196_3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.000000000000000000000000000000000000000000000000005228 196.0
HKD2_k127_4080196_4 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000003128 190.0
HKD2_k127_4080196_5 Domain of unknown function (DUF4131) K02238 - - 0.0000000000000000000000000000000000004274 151.0
HKD2_k127_4080196_6 Glycosyl transferase, WecB TagA CpsF family K05946 - 2.4.1.187 0.00000000000000000000000000007003 128.0
HKD2_k127_4080196_7 Competence protein ComEC K02238 - - 0.00000000000000000000000004776 119.0
HKD2_k127_4080196_8 - K01278,K03561,K12287 - 3.4.14.5 0.00000000000000004562 96.0
HKD2_k127_4080196_9 Transcription factor zinc-finger K09981 - - 0.000002505 57.0
HKD2_k127_4138605_0 ATP-grasp domain K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000001194 218.0
HKD2_k127_4138605_1 COG0530 Ca2 Na antiporter K07301 - - 0.00000003593 63.0
HKD2_k127_4210185_0 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000009204 166.0
HKD2_k127_4210185_1 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.0000000000000000000000000000001091 130.0
HKD2_k127_4334665_0 Sortase family K07284 - 3.4.22.70 0.0000001251 60.0
HKD2_k127_4334665_1 Domain of unknown function DUF11 - - - 0.0001748 55.0
HKD2_k127_4485413_0 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000617 378.0
HKD2_k127_4485413_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 353.0
HKD2_k127_4485413_10 His Kinase A (phosphoacceptor) domain K14982 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.00000000000000000000000000000000000000003357 165.0
HKD2_k127_4485413_11 Pep-cterm family integral membrane protein - - - 0.000000000000000000000000000009465 139.0
HKD2_k127_4485413_12 PFAM Secreted repeat of - - - 0.00000000000000000000000009372 115.0
HKD2_k127_4485413_13 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000004469 108.0
HKD2_k127_4485413_14 - - - - 0.00000000000000000000001632 109.0
HKD2_k127_4485413_15 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.0000000000000000000000801 101.0
HKD2_k127_4485413_16 Domain of unknown function (DUF4342) - - - 0.00000000000000000001176 94.0
HKD2_k127_4485413_17 NUDIX domain - - - 0.0000000000000000000187 97.0
HKD2_k127_4485413_18 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000002924 104.0
HKD2_k127_4485413_19 Cupredoxin-like domain - - - 0.0000000000000000000597 93.0
HKD2_k127_4485413_2 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 312.0
HKD2_k127_4485413_20 Belongs to the cytochrome b5 family - - - 0.0000000000000000001135 93.0
HKD2_k127_4485413_21 Acyltransferase family - - - 0.0000000000000000004669 98.0
HKD2_k127_4485413_22 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000004958 96.0
HKD2_k127_4485413_23 Protein of unknown function (DUF1003) - - - 0.0000000000000003374 85.0
HKD2_k127_4485413_24 Transcription factor zinc-finger K09981 - - 0.00000000000164 74.0
HKD2_k127_4485413_26 Zinc-dependent metalloprotease - - - 0.0000000009404 66.0
HKD2_k127_4485413_27 - - - - 0.00000001049 63.0
HKD2_k127_4485413_28 - - - - 0.00000002161 57.0
HKD2_k127_4485413_29 Matrixin - - - 0.00000007177 59.0
HKD2_k127_4485413_3 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 287.0
HKD2_k127_4485413_30 phosphoribosylanthranilate isomerase activity - - - 0.000002427 55.0
HKD2_k127_4485413_31 - - - - 0.0000166 52.0
HKD2_k127_4485413_32 SET domain K07117 - - 0.00009303 49.0
HKD2_k127_4485413_4 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002542 276.0
HKD2_k127_4485413_5 Efflux ABC transporter permease protein K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001514 272.0
HKD2_k127_4485413_6 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003235 260.0
HKD2_k127_4485413_7 Two component transcriptional regulator, winged helix family K07665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001876 250.0
HKD2_k127_4485413_8 phospholipase C - - - 0.0000000000000000000000000000000000000000000000000000001314 207.0
HKD2_k127_4485413_9 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000002704 184.0
HKD2_k127_4526237_0 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 629.0
HKD2_k127_4526237_1 ATP-dependent DNA helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 514.0
HKD2_k127_4526237_10 PFAM UbiA prenyltransferase - - - 0.000000000000000000000000000000000000000004947 165.0
HKD2_k127_4526237_11 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000007484 162.0
HKD2_k127_4526237_12 Glycosyl transferase family 4 - - - 0.0000000000000000000000000000000000000001207 168.0
HKD2_k127_4526237_13 chaperone-mediated protein folding - - - 0.0000000000000000000000000000000004276 149.0
HKD2_k127_4526237_14 TRANSCRIPTIONal - - - 0.000000000000000000000000000000106 139.0
HKD2_k127_4526237_15 FemAB family K05363,K11693 - 2.3.2.10,2.3.2.16 0.00000000000000002153 93.0
HKD2_k127_4526237_16 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00002415 57.0
HKD2_k127_4526237_17 Protein of unknown function (DUF3616) - - - 0.0001679 54.0
HKD2_k127_4526237_18 Methyltransferase FkbM domain - - - 0.0004444 50.0
HKD2_k127_4526237_2 aminopeptidase activity K19689 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005082 476.0
HKD2_k127_4526237_3 Uncharacterized membrane protein (DUF2298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 371.0
HKD2_k127_4526237_4 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000009213 222.0
HKD2_k127_4526237_5 TatD related DNase K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000008891 196.0
HKD2_k127_4526237_6 Glycosyl transferase family group 2 - - - 0.000000000000000000000000000000000000000000000000001328 201.0
HKD2_k127_4526237_7 Methicillin resistance protein - - - 0.000000000000000000000000000000000000000000000000224 188.0
HKD2_k127_4526237_8 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000002091 185.0
HKD2_k127_4526237_9 RmuC family K09760 - - 0.000000000000000000000000000000000000000000003783 176.0
HKD2_k127_4533452_0 DNA polymerase K02337 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.7.7.7 1.855e-236 761.0
HKD2_k127_4533452_1 Glycosyl hydrolases family 15 K07190 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001905 270.0
HKD2_k127_4533452_2 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000401 149.0
HKD2_k127_4533452_3 PFAM glycosyl transferase family 39 - - - 0.0000000000000000000000000000000000001025 161.0
HKD2_k127_4533452_4 AAA domain - - - 0.000000000000000000000000000000000003287 144.0
HKD2_k127_4533452_5 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000002981 108.0
HKD2_k127_4533452_6 EDD domain protein, DegV family - - - 0.000000000000000004983 94.0
HKD2_k127_4625103_0 PFAM TrkA-N domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008892 372.0
HKD2_k127_4625103_1 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000002162 219.0
HKD2_k127_4625103_2 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids K03733 - - 0.000000000000000000000000000000007635 139.0
HKD2_k127_4625103_3 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000001659 110.0
HKD2_k127_4625103_4 Tetratricopeptide repeat - - - 0.00000000000000000008247 99.0
HKD2_k127_466472_0 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 4.52e-231 736.0
HKD2_k127_466472_1 ABC transporter, ATP-binding protein K06147,K18893 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005307 412.0
HKD2_k127_466472_10 Belongs to the DsbB family K03611 - - 0.00000000000000000000000000000000000000000005135 164.0
HKD2_k127_466472_11 Protein of unknown function (DUF1003) - - - 0.0000000000000000000000000000000000000000001175 164.0
HKD2_k127_466472_12 PFAM TspO MBR family K05770 - - 0.000000000000000000000000000000000000000001128 162.0
HKD2_k127_466472_13 Thioredoxin - - - 0.00000000000000000000000000000000000000001844 160.0
HKD2_k127_466472_14 TRANSCRIPTIONal - - - 0.0000000000000000000000000000000000173 152.0
HKD2_k127_466472_15 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000000000001736 143.0
HKD2_k127_466472_16 COGs COG4633 conserved - - - 0.0000000000000000000000000001643 118.0
HKD2_k127_466472_18 glycosyl hydrolase, BNR repeat-containing protein - - - 0.0000000000000000000003917 110.0
HKD2_k127_466472_19 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase K19200 - - 0.0000000000000000000004425 108.0
HKD2_k127_466472_2 Cytochrome C biogenesis protein transmembrane region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000779 321.0
HKD2_k127_466472_20 Rhodanese Homology Domain - - - 0.000000000000000000005855 98.0
HKD2_k127_466472_22 AAA domain - - - 0.0000000001068 70.0
HKD2_k127_466472_23 Short C-terminal domain K08982 - - 0.0000000004458 63.0
HKD2_k127_466472_24 Protein of unknown function (DUF1573) - - - 0.00000002056 62.0
HKD2_k127_466472_25 PFAM pfkB family carbohydrate kinase - - - 0.0000003423 61.0
HKD2_k127_466472_26 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000009897 60.0
HKD2_k127_466472_27 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704 2.3.1.180 0.0001553 53.0
HKD2_k127_466472_3 Belongs to the MEMO1 family K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002853 275.0
HKD2_k127_466472_4 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001744 253.0
HKD2_k127_466472_5 PhoQ Sensor - - - 0.000000000000000000000000000000000000000000000000000000000000002898 235.0
HKD2_k127_466472_6 inorganic diphosphatase activity K01507,K01514,K15986 - 3.6.1.1,3.6.1.11 0.00000000000000000000000000000000000000000000000000000000000004379 225.0
HKD2_k127_466472_7 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000001342 210.0
HKD2_k127_466472_8 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000003506 202.0
HKD2_k127_466472_9 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.00000000000000000000000000000000000000000000001375 183.0
HKD2_k127_4804263_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 2.244e-247 792.0
HKD2_k127_4804263_1 membrane - - - 0.00000000000000000009735 104.0
HKD2_k127_4804263_2 Spermidine synthase K00797 - 2.5.1.16 0.0000000000000002513 85.0
HKD2_k127_4804263_3 beta-propeller repeat - - - 0.0002834 53.0
HKD2_k127_4879993_0 alpha-ribazole phosphatase activity K01834 - 5.4.2.11 0.0000000000000000002999 95.0
HKD2_k127_4879993_1 PFAM polysaccharide biosynthesis protein K03328 - - 0.00000000000004609 82.0
HKD2_k127_5062984_0 PFAM Protein synthesis factor, GTP-binding K06207 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 615.0
HKD2_k127_5062984_1 Belongs to the ClpA ClpB family K03696 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004625 326.0
HKD2_k127_5062984_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002333 269.0
HKD2_k127_5062984_3 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.000000000000000000000000000000000009683 143.0
HKD2_k127_5062984_4 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000008227 85.0
HKD2_k127_5092737_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 573.0
HKD2_k127_5092737_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 303.0
HKD2_k127_5092737_2 phenylalanyl-tRNA synthetase (beta subunit) K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000001027 218.0
HKD2_k127_5092737_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000001688 153.0
HKD2_k127_5092737_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000001094 115.0
HKD2_k127_5092737_5 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.000000000000001184 85.0
HKD2_k127_5092737_6 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.0000000006944 61.0
HKD2_k127_5092737_7 Heat shock protein - - - 0.00000000123 66.0
HKD2_k127_5092737_8 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00003771 48.0
HKD2_k127_5334735_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 454.0
HKD2_k127_5334735_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 415.0
HKD2_k127_5334735_10 Sugar-specific transcriptional regulator TrmB - - - 0.0000000000000007597 87.0
HKD2_k127_5334735_11 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) K00790 - 2.5.1.7 0.000000000248 61.0
HKD2_k127_5334735_12 sortase family K07284 - 3.4.22.70 0.00002424 55.0
HKD2_k127_5334735_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 384.0
HKD2_k127_5334735_3 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 314.0
HKD2_k127_5334735_4 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000001333 263.0
HKD2_k127_5334735_5 PFAM RNA binding S1 domain protein K02945 - - 0.00000000000000000000000000000000000000000000000000000000262 214.0
HKD2_k127_5334735_6 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000005035 206.0
HKD2_k127_5334735_7 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000001016 186.0
HKD2_k127_5334735_8 6-O-methylguanine DNA methyltransferase, DNA binding domain K07443 - - 0.00000000000000000000000000002834 119.0
HKD2_k127_5334735_9 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.00000000000000000007331 103.0
HKD2_k127_5386612_0 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000002538 156.0
HKD2_k127_5386612_1 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000004859 157.0
HKD2_k127_5386612_2 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000003179 121.0
HKD2_k127_5386612_3 ComF family K02242 - - 0.000000000000000000000000003502 121.0
HKD2_k127_5386612_4 integral membrane protein - - - 0.0000000000000001308 92.0
HKD2_k127_5386612_5 GDP-mannose mannosyl hydrolase activity K03574 - 3.6.1.55 0.0000000000000002613 84.0
HKD2_k127_5386612_6 protein folding K09513 - - 0.00000000000008249 84.0
HKD2_k127_5386612_7 stage II sporulation K06381 - - 0.0000000002887 73.0
HKD2_k127_5461958_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009697 450.0
HKD2_k127_5461958_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000007533 230.0
HKD2_k127_5461958_2 N-acetylglucosaminylinositol deacetylase activity - - - 0.00000000000000000005033 99.0
HKD2_k127_5461958_3 HAD-hyrolase-like K19270 - 3.1.3.23 0.0000000000000000001167 97.0
HKD2_k127_5461958_4 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.000004904 51.0
HKD2_k127_56105_0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 364.0
HKD2_k127_56105_1 Belongs to the MurCDEF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008065 312.0
HKD2_k127_56105_2 Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000002732 271.0
HKD2_k127_56105_3 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000002432 263.0
HKD2_k127_56105_4 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002904 265.0
HKD2_k127_56105_5 Peptidoglycan-binding LysM - - - 0.0000000000000000000000000000000000000000000000000000000002265 217.0
HKD2_k127_56105_6 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.13 0.0000000000000000000000000000000000000000001072 172.0
HKD2_k127_56105_7 DUF218 domain - - - 0.0000000000000000000839 98.0
HKD2_k127_56105_8 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.00000004685 62.0
HKD2_k127_56105_9 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E K07025 - - 0.0001122 52.0
HKD2_k127_6394864_0 helicase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 399.0
HKD2_k127_6394864_1 Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins K07533 - 5.2.1.8 0.000000000000002168 84.0
HKD2_k127_6409199_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1164.0
HKD2_k127_6409199_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 0.0 1157.0
HKD2_k127_6409199_10 UreE urease accessory protein, C-terminal domain K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000006872 195.0
HKD2_k127_6409199_11 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000008235 184.0
HKD2_k127_6409199_12 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000008632 183.0
HKD2_k127_6409199_13 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000001056 184.0
HKD2_k127_6409199_14 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000002684 144.0
HKD2_k127_6409199_15 Ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.0000000000000000000005846 100.0
HKD2_k127_6409199_16 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000001656 96.0
HKD2_k127_6409199_17 PFAM peptidase C60 sortase A and B - - - 0.000000000000000229 88.0
HKD2_k127_6409199_18 Modulates RecA activity K03565 - - 0.00000000000002666 79.0
HKD2_k127_6409199_19 Likely ribonuclease with RNase H fold. K07447 - - 0.0000000000007903 74.0
HKD2_k127_6409199_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005456 544.0
HKD2_k127_6409199_20 SMART helix-turn-helix domain protein - - - 0.0000000001456 70.0
HKD2_k127_6409199_3 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 537.0
HKD2_k127_6409199_4 FtsK SpoIIIE family protein K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006388 514.0
HKD2_k127_6409199_5 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001703 481.0
HKD2_k127_6409199_6 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003833 438.0
HKD2_k127_6409199_7 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002107 288.0
HKD2_k127_6409199_8 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000001277 258.0
HKD2_k127_6409199_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.000000000000000000000000000000000000000000000000000004156 196.0
HKD2_k127_6581002_0 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000008869 189.0
HKD2_k127_6581002_1 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000004427 199.0
HKD2_k127_6581002_2 oligosaccharyl transferase activity K07151 - 2.4.99.18 0.00000000000000000000000000000000000000000000001274 191.0
HKD2_k127_6581002_3 Polysaccharide biosynthesis protein K03328 - - 0.00000000000000000002127 98.0
HKD2_k127_6581002_4 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000006406 81.0
HKD2_k127_6746133_0 PFAM Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003925 297.0
HKD2_k127_6746133_1 PFAM Transketolase, C-terminal domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000009459 217.0
HKD2_k127_6746133_2 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.00000000000000006696 85.0
HKD2_k127_6746133_3 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000001329 87.0
HKD2_k127_6746133_4 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides K07264 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016763,GO:0033692,GO:0034637,GO:0034645,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.2.43 0.0005554 52.0
HKD2_k127_7035834_0 Male sterility protein K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006619 374.0
HKD2_k127_7035834_1 Nucleotidyl transferase K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008669 280.0
HKD2_k127_7035834_10 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000186 99.0
HKD2_k127_7035834_11 2'-5' RNA ligase superfamily K01975 - 3.1.4.58 0.00000000001153 73.0
HKD2_k127_7035834_12 PFAM Cyclic nucleotide-binding K10914 - - 0.000005071 50.0
HKD2_k127_7035834_13 CAAX protease self-immunity K07052 - - 0.0004594 51.0
HKD2_k127_7035834_2 GtrA-like protein K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000003664 252.0
HKD2_k127_7035834_3 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000003376 238.0
HKD2_k127_7035834_4 COG0330 Membrane protease subunits stomatin prohibitin homologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000002893 237.0
HKD2_k127_7035834_5 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 0.000000000000000000000000000000002069 138.0
HKD2_k127_7035834_6 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.000000000000000000000000000000002124 136.0
HKD2_k127_7035834_7 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity - - - 0.00000000000000000000000000000001019 140.0
HKD2_k127_7035834_8 Cysteine-rich secretory protein family - - - 0.00000000000000000000000000199 123.0
HKD2_k127_7035834_9 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000001853 111.0
HKD2_k127_7188497_0 AraC-like ligand binding domain - - - 0.0000000000000000000000000000000000000000000002515 170.0
HKD2_k127_7188497_1 PFAM Isoprenylcysteine carboxyl methyltransferase - - - 0.0000000000000000000006078 100.0
HKD2_k127_7188497_2 FecR protein - - - 0.0002572 51.0
HKD2_k127_7188497_3 Exopolysaccharide biosynthesis protein - - - 0.0005554 51.0
HKD2_k127_7213829_0 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 522.0
HKD2_k127_7213829_1 Maltogenic Amylase, C-terminal domain K05341,K05343 - 2.4.1.4,3.2.1.1,5.4.99.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 350.0
HKD2_k127_7213829_2 alpha beta alpha domain I K01840,K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 301.0
HKD2_k127_7213829_3 Starch synthase catalytic domain - - - 0.000000000000000000000000000000000000000000628 162.0
HKD2_k127_7553153_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 3.373e-302 948.0
HKD2_k127_7553153_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 446.0
HKD2_k127_7553153_10 PFAM peptidase C60, sortase A and B K07284 - 3.4.22.70 0.00000000000001245 81.0
HKD2_k127_7553153_11 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000003763 82.0
HKD2_k127_7553153_12 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000004267 76.0
HKD2_k127_7553153_13 LysM domain - - - 0.00000000008885 70.0
HKD2_k127_7553153_14 Domain of unknown function K20276 - - 0.000000002131 67.0
HKD2_k127_7553153_15 -O-antigen K02847 - - 0.00000004669 65.0
HKD2_k127_7553153_16 RecB family exonuclease. Source PGD - - - 0.0000002257 62.0
HKD2_k127_7553153_17 NUDIX domain - - - 0.000001098 57.0
HKD2_k127_7553153_18 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00002116 50.0
HKD2_k127_7553153_19 cellulase activity - - - 0.0000259 56.0
HKD2_k127_7553153_2 DNA polymerase X family K02347 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 405.0
HKD2_k127_7553153_21 the current gene model (or a revised gene model) may contain a frame shift - - - 0.0001609 47.0
HKD2_k127_7553153_22 LysM domain - - - 0.0005772 49.0
HKD2_k127_7553153_3 Beta-Casp domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 321.0
HKD2_k127_7553153_4 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001734 272.0
HKD2_k127_7553153_5 COG2244 Membrane protein involved in the export of O-antigen and teichoic acid K03328,K16695 - - 0.000000000000000000000000000000000000000000000000000000000008443 223.0
HKD2_k127_7553153_6 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000000000000001959 198.0
HKD2_k127_7553153_7 Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000004934 149.0
HKD2_k127_7553153_8 LemA family K03744 - - 0.00000000000000000000000000002918 124.0
HKD2_k127_7553153_9 Glycosyl transferase family group 2 K16557 - - 0.0000000000000000000000000005108 125.0
HKD2_k127_7758869_0 Cell division protein FtsA K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 397.0
HKD2_k127_7758869_1 PFAM peptidase M16 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000002004 234.0
HKD2_k127_7758869_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:1901360 2.7.4.6 0.0000000000000000000000000000000000000000000001955 174.0
HKD2_k127_7758869_3 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000008466 142.0
HKD2_k127_7758869_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000000000000000000000009205 117.0
HKD2_k127_7758869_5 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000003048 121.0
HKD2_k127_7758869_6 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000006738 104.0
HKD2_k127_7758869_7 PFAM PEGA domain - - - 0.000008723 58.0
HKD2_k127_7936673_0 Glycosyl transferase family 2 K07011 - - 0.0000000000000000000000000000000000000000000000000000000001349 214.0
HKD2_k127_7936673_1 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000006843 169.0
HKD2_k127_7936673_2 glycosyl transferase, family 39 - - - 0.000000000000000000000000000000000000000001143 175.0
HKD2_k127_7936673_3 Glycosyl transferase family 2 K12984 - - 0.00000000000000000000000000000000001372 145.0
HKD2_k127_7936673_4 Glycosyl transferases group 1 - - - 0.000000000000000000009564 102.0
HKD2_k127_8026991_0 Mazg nucleotide pyrophosphohydrolase - - - 0.0000000000000000000000000003104 116.0
HKD2_k127_8026991_1 Chaperone - - - 0.000000004248 68.0
HKD2_k127_8221673_0 Anticodon-binding domain of tRNA K01870 - 6.1.1.5 1.292e-299 946.0
HKD2_k127_8221673_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0030428,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 407.0
HKD2_k127_8221673_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000781 275.0
HKD2_k127_8221673_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000004009 233.0
HKD2_k127_8221673_4 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000333 188.0
HKD2_k127_8221673_5 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000005357 147.0
HKD2_k127_8221673_6 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - 0.0000000000000000004558 89.0
HKD2_k127_8221673_7 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000001044 82.0
HKD2_k127_8680819_0 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000001023 232.0
HKD2_k127_8680819_1 Uncharacterized protein conserved in bacteria (DUF2330) - - - 0.00000000000000000000004743 114.0
HKD2_k127_8680819_2 Camelysin metallo-endopeptidase - - - 0.00000000000000002773 94.0
HKD2_k127_8680819_3 PFAM von Willebrand factor type A - - - 0.0000000003752 66.0
HKD2_k127_8820090_0 Participates in initiation and elongation during chromosome replication K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 432.0
HKD2_k127_8820090_1 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 349.0
HKD2_k127_8820090_10 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.00000000000000000000000000257 121.0
HKD2_k127_8820090_11 Binds the 23S rRNA K02909 - - 0.000000000000000000000209 100.0
HKD2_k127_8820090_12 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000006689 87.0
HKD2_k127_8820090_13 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000001959 81.0
HKD2_k127_8820090_14 response regulator receiver - - - 0.0000000000000003234 83.0
HKD2_k127_8820090_15 Transporter Family - - - 0.0000000000002855 80.0
HKD2_k127_8820090_16 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000002494 72.0
HKD2_k127_8820090_17 endonuclease containing a URI domain K07461 - - 0.00000000000295 69.0
HKD2_k127_8820090_18 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - 0.0000000003584 64.0
HKD2_k127_8820090_2 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001604 282.0
HKD2_k127_8820090_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006729 263.0
HKD2_k127_8820090_4 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000515 265.0
HKD2_k127_8820090_5 PDZ domain (Also known as DHR or GLGF) K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000003038 238.0
HKD2_k127_8820090_6 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000001819 216.0
HKD2_k127_8820090_7 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000001013 211.0
HKD2_k127_8820090_8 TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000001322 166.0
HKD2_k127_8820090_9 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000317 143.0
HKD2_k127_8854145_0 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000002987 237.0
HKD2_k127_8854145_1 PFAM glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000656 195.0
HKD2_k127_8854145_2 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000005484 181.0
HKD2_k127_8854145_3 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000001919 152.0
HKD2_k127_8854145_4 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000412 138.0
HKD2_k127_8854145_5 glycosyl transferase family 2 - - - 0.0000000000001841 72.0
HKD2_k127_8854145_6 O-Antigen ligase - - - 0.00000001069 67.0
HKD2_k127_9007542_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K06950 - - 0.0000000000000000000000000000000000000000000001382 175.0
HKD2_k127_9007542_10 Membrane K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000000003448 74.0
HKD2_k127_9007542_11 Nudix hydrolase K03574 - 3.6.1.55 0.0000009638 58.0
HKD2_k127_9007542_2 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.0000000000000000000000000000000000008078 153.0
HKD2_k127_9007542_3 ATP-grasp domain K01921 - 6.3.2.4 0.0000000000000000000000000000000007615 143.0
HKD2_k127_9007542_4 HD domain K07023 - - 0.000000000000000000000000000007326 126.0
HKD2_k127_9007542_5 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K00797,K01611 - 2.5.1.16,4.1.1.50 0.0000000000000000000000000001493 120.0
HKD2_k127_9007542_6 - - - - 0.0000000000000000000000001033 113.0
HKD2_k127_9007542_7 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000002279 106.0
HKD2_k127_9007542_8 Acetyltransferase (GNAT) domain - - - 0.0000000000000001344 91.0
HKD2_k127_9007542_9 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000002091 86.0
HKD2_k127_9054854_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 368.0
HKD2_k127_9054854_1 TIGRFAM DNA polymerase III, alpha subunit K02337,K14162 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000006684 263.0
HKD2_k127_9054854_2 Arabinose efflux permease - - - 0.00000000000000001216 94.0
HKD2_k127_9116869_0 Participates in transcription elongation, termination and antitermination K02601 - - 0.000000000000000000000000000000000000000000000000000000000000007006 223.0
HKD2_k127_9116869_1 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000001702 185.0
HKD2_k127_9116869_2 Guanylate kinase K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009507,GO:0009536,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040008,GO:0042278,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0048638,GO:0050145,GO:0050789,GO:0050793,GO:0055086,GO:0065007,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.000000000000000000000004834 109.0
HKD2_k127_9116869_3 Required for morphogenesis under gluconeogenic growth conditions - - - 0.00000000000000000000003829 111.0
HKD2_k127_9116869_4 Belongs to the UPF0102 family K07460 - - 0.0000000000000000001077 93.0
HKD2_k127_9116869_5 Serine aminopeptidase, S33 - - - 0.0000000003625 66.0
HKD2_k127_9116869_6 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000005509 50.0
HKD2_k127_9341967_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007644 400.0
HKD2_k127_9341967_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 316.0
HKD2_k127_9341967_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000001838 68.0
HKD2_k127_9341967_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000001973 53.0
HKD2_k127_9477648_0 Type II IV secretion system protein K02454,K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 428.0
HKD2_k127_9477648_1 Type II secretion system (T2SS), protein F K02455,K02653,K12278 - - 0.00000000000000000000000000000000000000006774 166.0
HKD2_k127_9477648_2 LVIVD repeat - - - 0.000000001678 70.0
HKD2_k127_9493039_0 MgsA AAA+ ATPase C terminal K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007026 396.0
HKD2_k127_9493039_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001617 255.0
HKD2_k127_9493039_10 - - - - 0.0000000000188 70.0
HKD2_k127_9493039_11 Response regulator, receiver K02487,K02657,K02658,K06596 - - 0.0000001711 58.0
HKD2_k127_9493039_12 LytR cell envelope-related transcriptional attenuator - - - 0.0003805 51.0
HKD2_k127_9493039_13 Succinylglutamate desuccinylase / Aspartoacylase family - - - 0.0007723 51.0
HKD2_k127_9493039_2 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000006188 242.0
HKD2_k127_9493039_3 nitric oxide dioxygenase activity - - - 0.0000000000000000000000000000000000000000000000000001767 202.0
HKD2_k127_9493039_4 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000008324 150.0
HKD2_k127_9493039_5 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 GO:0000270,GO:0000271,GO:0003674,GO:0003824,GO:0003977,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0030203,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 0.00000000000000000000000000009344 125.0
HKD2_k127_9493039_6 PFAM glycosyl transferase family 39 - - - 0.0000000000000000000001901 112.0
HKD2_k127_9493039_7 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K11329 - - 0.0000000000000000000002663 101.0
HKD2_k127_9493039_8 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000001102 100.0
HKD2_k127_9493039_9 Transcriptional regulator K02483 - - 0.00000000000000001934 87.0
HKD2_k127_961782_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 6.227e-283 892.0
HKD2_k127_961782_1 PFAM E1-E2 ATPase-associated domain protein, Haloacid dehalogenase domain protein hydrolase, cation transporting ATPase domain protein K01531 - 3.6.3.2 1.981e-202 656.0
HKD2_k127_961782_10 PolyA polymerase K00974 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 312.0
HKD2_k127_961782_11 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002862 271.0
HKD2_k127_961782_12 Protein of unknown function (DUF3048) C-terminal domain - - - 0.0000000000000000000000000000000000000000000000002268 193.0
HKD2_k127_961782_13 - - - - 0.0000000000000000000000000000000000000000000000009624 181.0
HKD2_k127_961782_14 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.000000000000000000000000000000000000000000007382 174.0
HKD2_k127_961782_15 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000004571 168.0
HKD2_k127_961782_17 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000004682 141.0
HKD2_k127_961782_18 Belongs to the inositol monophosphatase superfamily K01092 - 3.1.3.25 0.00000000000000000000000000000005338 135.0
HKD2_k127_961782_19 Pfam:UPF0118 - - - 0.00000000000000000000000000002121 130.0
HKD2_k127_961782_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000228 452.0
HKD2_k127_961782_20 3-demethylubiquinone-9 3-O-methyltransferase activity K00568 GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 0.000000000000000000000003324 112.0
HKD2_k127_961782_21 DEAD DEAH box helicase domain protein K06877 - - 0.0000000000000000000001197 107.0
HKD2_k127_961782_22 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.000000000000000000000279 104.0
HKD2_k127_961782_23 membrane K08978 - - 0.0000000000000009281 83.0
HKD2_k127_961782_24 transcriptional - - - 0.00000000000002245 80.0
HKD2_k127_961782_25 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009889,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2001141 - 0.000000000001178 71.0
HKD2_k127_961782_26 Protein of unknown function (DUF4446) - - - 0.000000000008598 71.0
HKD2_k127_961782_28 ABC-2 family transporter protein K01992 - - 0.00000000002272 75.0
HKD2_k127_961782_29 ABC-2 family transporter protein K01992 - - 0.000000001791 68.0
HKD2_k127_961782_3 methionine adenosyltransferase activity K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 383.0
HKD2_k127_961782_30 K02342 DNA polymerase III subunit epsilon K09951 - - 0.0000004516 59.0
HKD2_k127_961782_31 ABC-2 family transporter protein K01992 - - 0.000003085 57.0
HKD2_k127_961782_32 COG0739 Membrane proteins related to metalloendopeptidases K21471 - - 0.00003798 54.0
HKD2_k127_961782_33 SpoVT / AbrB like domain - - - 0.0002547 45.0
HKD2_k127_961782_4 (ABC) transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 374.0
HKD2_k127_961782_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 347.0
HKD2_k127_961782_6 L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp K01876,K09759 - 6.1.1.12,6.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004292 342.0
HKD2_k127_961782_7 Endoribonuclease that initiates mRNA decay K18682 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 326.0
HKD2_k127_961782_8 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885,K09698 - 6.1.1.17,6.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008571 323.0
HKD2_k127_961782_9 Single-stranded-DNA-specific exonuclease recj K07462 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003474 316.0
HKD2_k127_9708477_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1128.0
HKD2_k127_9708477_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.589e-248 784.0
HKD2_k127_9708477_10 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.00000000000000000000000000000000000000000000001358 178.0
HKD2_k127_9708477_11 - - - - 0.00000000000000000000000000000000000000000000002238 175.0
HKD2_k127_9708477_12 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000007941 139.0
HKD2_k127_9708477_13 PFAM cytochrome c biogenesis protein, transmembrane region - - - 0.000000000000000000000000000000002813 139.0
HKD2_k127_9708477_14 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000005187 128.0
HKD2_k127_9708477_15 - - - - 0.00000000000000000000000153 108.0
HKD2_k127_9708477_16 quinone binding - - - 0.000000000000000236 83.0
HKD2_k127_9708477_17 Evidence 5 No homology to any previously reported sequences K09005 - - 0.0000000000000034 89.0
HKD2_k127_9708477_18 PFAM membrane protein of K08972 - - 0.00000003851 60.0
HKD2_k127_9708477_19 VIT family - - - 0.0000003293 58.0
HKD2_k127_9708477_2 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 1.087e-237 757.0
HKD2_k127_9708477_20 Preprotein translocase SecG subunit K03075 - - 0.0000003463 54.0
HKD2_k127_9708477_21 - - - - 0.00001333 56.0
HKD2_k127_9708477_3 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 548.0
HKD2_k127_9708477_4 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 385.0
HKD2_k127_9708477_5 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003 262.0
HKD2_k127_9708477_6 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000009765 217.0
HKD2_k127_9708477_7 Protein of unknown function (DUF1295) - - - 0.00000000000000000000000000000000000000000000000000000002504 205.0
HKD2_k127_9708477_8 Sugar isomerase (SIS) K15916 - 5.3.1.8,5.3.1.9 0.0000000000000000000000000000000000000000000000006145 188.0
HKD2_k127_9708477_9 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000001458 182.0
HKD2_k127_9726518_0 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000001471 84.0
HKD2_k127_9726518_1 Bacterial protein of unknown function (DUF916) K00226 - 1.3.98.1 0.000000000002006 79.0
HKD2_k127_9726518_2 PFAM glycosyl transferase family 39 - - - 0.00000000001378 73.0
HKD2_k127_9726518_3 Lysin motif - - - 0.0000009654 61.0
HKD2_k127_9726518_4 Pectate lyase - - - 0.00005465 50.0
HKD2_k127_9790518_0 lysyl-tRNA synthetase K04568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009622 264.0
HKD2_k127_9790518_1 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000001247 160.0
HKD2_k127_9790518_10 PFAM response regulator receiver K07665 - - 0.00000000000000000002173 92.0
HKD2_k127_9790518_11 HD superfamily hydrolase K06950 - - 0.000000000001688 75.0
HKD2_k127_9790518_12 Pentapeptide repeat - - - 0.000000000004168 74.0
HKD2_k127_9790518_13 Cyclic nucleotide-monophosphate binding domain K10914,K21828 - - 0.000000005786 59.0
HKD2_k127_9790518_14 PFAM blue (type 1) copper domain protein - - - 0.000001777 56.0
HKD2_k127_9790518_15 Crp-like helix-turn-helix domain - - - 0.00001459 53.0
HKD2_k127_9790518_2 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000001423 156.0
HKD2_k127_9790518_3 Protein of unknown function (DUF1648) - - - 0.000000000000000000000000000000000000000278 156.0
HKD2_k127_9790518_4 Nudix hydrolase - GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0016787,GO:0019538,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000001329 144.0
HKD2_k127_9790518_5 PFAM ATP-binding region K02484 - 2.7.13.3 0.00000000000000000000000000000001058 143.0
HKD2_k127_9790518_6 NUDIX domain K03574,K17816 GO:0000003,GO:0001669,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006259,GO:0006281,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0007154,GO:0007275,GO:0007548,GO:0007568,GO:0008150,GO:0008152,GO:0008406,GO:0008413,GO:0008584,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0012505,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022414,GO:0030141,GO:0030515,GO:0031090,GO:0031410,GO:0031668,GO:0031965,GO:0031967,GO:0031974,GO:0031975,GO:0031982,GO:0032501,GO:0032502,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0035539,GO:0036219,GO:0042221,GO:0042262,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044421,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044713,GO:0044714,GO:0045137,GO:0046060,GO:0046061,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046546,GO:0046661,GO:0046686,GO:0046700,GO:0047429,GO:0047693,GO:0048513,GO:0048608,GO:0048731,GO:0048856,GO:0050896,GO:0051716,GO:0055086,GO:0061458,GO:0070013,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:0090304,GO:0097159,GO:0097223,GO:0097708,GO:0099503,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.6.1.55,3.6.1.56 0.00000000000000000000000000000003229 132.0
HKD2_k127_9790518_7 Dihydrofolate reductase K00287 - 1.5.1.3 0.000000000000000000000000003002 118.0
HKD2_k127_9790518_8 RNHCP domain - - - 0.00000000000000000000000001533 113.0
HKD2_k127_9790518_9 Putative helix-turn-helix protein, YlxM / p13 like - - - 0.0000000000000000000000001296 108.0
HKD2_k127_9838803_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 7.573e-277 872.0
HKD2_k127_9838803_1 Heat shock 70 kDa protein K04043 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 4.462e-228 722.0
HKD2_k127_9838803_10 MviN-like protein K03980 - - 0.0000000000000000000000000000000000000000000000000000000000001899 233.0
HKD2_k127_9838803_11 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000009331 214.0
HKD2_k127_9838803_12 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000111 215.0
HKD2_k127_9838803_13 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000001973 230.0
HKD2_k127_9838803_14 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000002196 207.0
HKD2_k127_9838803_15 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000009621 196.0
HKD2_k127_9838803_16 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000003288 189.0
HKD2_k127_9838803_17 Glycosyl hydrolases family 8 K01179,K20542 GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0008810,GO:0016787,GO:0016798 3.2.1.4 0.0000000000000000000000000000000000000000000000000762 203.0
HKD2_k127_9838803_18 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000002478 183.0
HKD2_k127_9838803_19 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000004137 173.0
HKD2_k127_9838803_2 GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 610.0
HKD2_k127_9838803_20 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000007734 169.0
HKD2_k127_9838803_21 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000008433 157.0
HKD2_k127_9838803_22 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000001219 157.0
HKD2_k127_9838803_23 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000005287 145.0
HKD2_k127_9838803_24 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000005769 141.0
HKD2_k127_9838803_25 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000001487 139.0
HKD2_k127_9838803_26 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000005499 136.0
HKD2_k127_9838803_27 Aminoacyl-tRNA editing domain - - - 0.00000000000000000000000000000000009921 138.0
HKD2_k127_9838803_28 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000009105 138.0
HKD2_k127_9838803_29 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000003039 121.0
HKD2_k127_9838803_3 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 608.0
HKD2_k127_9838803_30 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000008018 115.0
HKD2_k127_9838803_31 50S ribosomal protein L4 K02926 - - 0.000000000000000000000000001106 121.0
HKD2_k127_9838803_32 Glycosyl hydrolases family 39 K01198 - 3.2.1.37 0.0000000000000000000000004243 119.0
HKD2_k127_9838803_33 One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000001855 107.0
HKD2_k127_9838803_34 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.0000000000000000000001317 99.0
HKD2_k127_9838803_35 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 0.00000000000000000001453 94.0
HKD2_k127_9838803_36 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000001135 88.0
HKD2_k127_9838803_37 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A K02876 - - 0.00000000000000000178 90.0
HKD2_k127_9838803_38 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000002467 85.0
HKD2_k127_9838803_39 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000006719 79.0
HKD2_k127_9838803_4 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 411.0
HKD2_k127_9838803_40 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000001971 76.0
HKD2_k127_9838803_41 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000001557 74.0
HKD2_k127_9838803_42 Belongs to the bacterial ribosomal protein bL36 family K02919 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000002032 64.0
HKD2_k127_9838803_43 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000007025 64.0
HKD2_k127_9838803_44 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.00000006037 64.0
HKD2_k127_9838803_45 Binds directly to 16S ribosomal RNA K02968 - - 0.0002197 47.0
HKD2_k127_9838803_5 PFAM Glycosyl transferase family 2 K00694 - 2.4.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 387.0
HKD2_k127_9838803_6 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006575 371.0
HKD2_k127_9838803_7 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005022 315.0
HKD2_k127_9838803_8 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 291.0
HKD2_k127_9838803_9 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004437 295.0