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Overview

ID MAG01787
Name HKD2_bin.29
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Rariloculales
Family Rariloculaceae
Genus FEN-1219
Species
Assembly information
Completeness (%) 92.0
Contamination (%) 3.68
GC content (%) 68.0
N50 (bp) 26,592
Genome size (bp) 4,042,813

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3578

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10013018_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 1.674e-224 707.0
HKD2_k127_10013018_1 TonB-dependent receptor K02014 - - 1.063e-223 717.0
HKD2_k127_10013018_10 Integral membrane protein TerC family - - - 0.00000000000000000000000000000000000000000000000000000000004882 213.0
HKD2_k127_10013018_11 NHL repeat - - - 0.00000000000000000000000000000000000000000003824 179.0
HKD2_k127_10013018_12 TPM domain K08988 - - 0.00000000000000000000000000000000000000003338 162.0
HKD2_k127_10013018_13 - - - - 0.000000000000000000000000000000000000004661 149.0
HKD2_k127_10013018_14 Domain of unknown function (DUF4185) - - - 0.0000000000000000000000000000000002887 150.0
HKD2_k127_10013018_16 - - - - 0.0000000000000000000000008075 106.0
HKD2_k127_10013018_17 SNARE associated Golgi protein - - - 0.00000000000000000000007225 113.0
HKD2_k127_10013018_19 - - - - 0.0000000000000000000008326 111.0
HKD2_k127_10013018_2 Sucrose-6F-phosphate phosphohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 603.0
HKD2_k127_10013018_20 Phospholipid methyltransferase - - - 0.000000000000000000003579 106.0
HKD2_k127_10013018_21 histone acetyltransferase HPA2 and related acetyltransferases - GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 - 0.0000000000000000004467 98.0
HKD2_k127_10013018_22 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.000000000000006308 86.0
HKD2_k127_10013018_3 Belongs to the radical SAM superfamily. RlmN family K06941 - 2.1.1.192 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 444.0
HKD2_k127_10013018_4 DNA polymerase type-B family K02336 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 441.0
HKD2_k127_10013018_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006215 310.0
HKD2_k127_10013018_6 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 296.0
HKD2_k127_10013018_7 TPM domain K06872 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005186 249.0
HKD2_k127_10013018_8 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000023 248.0
HKD2_k127_10013018_9 Sulfotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000006048 233.0
HKD2_k127_1017878_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 1.022e-213 674.0
HKD2_k127_1017878_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 1.827e-201 642.0
HKD2_k127_1017878_10 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004268 259.0
HKD2_k127_1017878_11 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000000000004499 241.0
HKD2_k127_1017878_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000163 235.0
HKD2_k127_1017878_13 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.000000000000000000000000000000000000000000000000000000000007245 218.0
HKD2_k127_1017878_14 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000005453 200.0
HKD2_k127_1017878_15 lactoylglutathione lyase activity K03088 - - 0.000000000000000000000000000000000000000000000000001487 197.0
HKD2_k127_1017878_16 Amino-transferase class IV K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000001061 194.0
HKD2_k127_1017878_17 Putative restriction endonuclease - - - 0.00000000000000000000000000000000000003042 152.0
HKD2_k127_1017878_18 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 - - 0.00000000000000000000000000001585 128.0
HKD2_k127_1017878_19 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000001592 103.0
HKD2_k127_1017878_2 TIGRFAM Cell shape determining protein MreB Mrl K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 564.0
HKD2_k127_1017878_21 Belongs to the UPF0250 family K09158 - - 0.0000004221 63.0
HKD2_k127_1017878_3 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 566.0
HKD2_k127_1017878_4 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 424.0
HKD2_k127_1017878_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 405.0
HKD2_k127_1017878_6 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 351.0
HKD2_k127_1017878_7 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005544 319.0
HKD2_k127_1017878_8 Lytic murein transglycosylase K08305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000254 304.0
HKD2_k127_1017878_9 cell wall glycoprotein biosynthetic process K00344,K01809,K01840,K03431,K04035,K15778,K16881 GO:0000032,GO:0000271,GO:0003674,GO:0003824,GO:0004476,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006013,GO:0006056,GO:0006057,GO:0006139,GO:0006464,GO:0006486,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009242,GO:0009298,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019309,GO:0019318,GO:0019320,GO:0019438,GO:0019538,GO:0019673,GO:0031506,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0042546,GO:0043170,GO:0043412,GO:0043413,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046483,GO:0055086,GO:0070085,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.14.13.81,1.6.5.5,2.7.7.13,5.3.1.8,5.4.2.10,5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000004675 274.0
HKD2_k127_1173_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 7.092e-201 638.0
HKD2_k127_1173_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 437.0
HKD2_k127_1173_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001599 433.0
HKD2_k127_1173_3 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 394.0
HKD2_k127_1173_4 Alkyl hydroperoxide reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002709 234.0
HKD2_k127_1173_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000006932 180.0
HKD2_k127_1275890_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003234 447.0
HKD2_k127_1275890_1 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006807 447.0
HKD2_k127_1275890_2 PFAM NAD dependent epimerase dehydratase family K00091 - 1.1.1.219 0.000000000000000000000000000000000000004511 152.0
HKD2_k127_1321939_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 3.444e-285 890.0
HKD2_k127_1321939_1 Flagellar hook protein FlgE K02390 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 485.0
HKD2_k127_1321939_10 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005636 290.0
HKD2_k127_1321939_11 Belongs to the flagella basal body rod proteins family K02391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008718 252.0
HKD2_k127_1321939_12 Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella K02406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009323 244.0
HKD2_k127_1321939_13 belongs to the bacterial solute-binding protein 3 family K02030,K02424,K10036 - - 0.00000000000000000000000000000000000000000000000000000000000000004123 235.0
HKD2_k127_1321939_14 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02393 - - 0.0000000000000000000000000000000000000000000000000000000000001005 220.0
HKD2_k127_1321939_15 COG3951 Rod binding protein K02395 GO:0003674,GO:0005198 - 0.0000000000000000000000000000000000000000000000000000000001024 216.0
HKD2_k127_1321939_16 cheY-homologous receiver domain - - - 0.0000000000000000000000000000000000000000000000000000001104 209.0
HKD2_k127_1321939_17 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000393 192.0
HKD2_k127_1321939_18 domain protein - - - 0.0000000000000000000000000000000000000000000001776 181.0
HKD2_k127_1321939_19 Required for flagellar hook formation. May act as a scaffolding protein K02389 - - 0.0000000000000000000000000000000000000000006594 174.0
HKD2_k127_1321939_2 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation K02394 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 469.0
HKD2_k127_1321939_20 Protein of unknown function (DUF3237) - - - 0.000000000000000000000000000000000000000005838 162.0
HKD2_k127_1321939_21 Belongs to the flagella basal body rod proteins family K02388 - - 0.0000000000000000000000000000000000000002328 160.0
HKD2_k127_1321939_22 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body K02387 - - 0.000000000000000000000000000006718 126.0
HKD2_k127_1321939_23 Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly K02386 - - 0.0000000000000000000000326 111.0
HKD2_k127_1321939_24 DsrE/DsrF-like family - - - 0.000000000000000216 86.0
HKD2_k127_1321939_25 negative regulation of translational initiation - - - 0.000000000000000722 86.0
HKD2_k127_1321939_26 PilZ domain - - - 0.0000000000001523 74.0
HKD2_k127_1321939_27 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000004706 71.0
HKD2_k127_1321939_28 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000001223 70.0
HKD2_k127_1321939_29 FlgN protein - - - 0.000006589 54.0
HKD2_k127_1321939_3 Belongs to the flagella basal body rod proteins family K02396 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 439.0
HKD2_k127_1321939_31 COG2747 Negative regulator of flagellin synthesis (anti-sigma28 factor) K02398 - - 0.00008429 54.0
HKD2_k127_1321939_4 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006132 422.0
HKD2_k127_1321939_5 basal body rod K02392 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007219 373.0
HKD2_k127_1321939_6 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006098 361.0
HKD2_k127_1321939_7 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003745 346.0
HKD2_k127_1321939_8 Bacterial regulatory helix-turn-helix protein, lysR family K04761 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003383 344.0
HKD2_k127_1321939_9 Belongs to the bacterial flagellin family K02397 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009885 301.0
HKD2_k127_1329432_0 dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0015949,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 462.0
HKD2_k127_1329432_1 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007881 409.0
HKD2_k127_1329432_2 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000006401 261.0
HKD2_k127_1329432_3 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.000000000000000000000000000000000000000000000000216 181.0
HKD2_k127_1329432_4 Protein of unknown function (DUF445) - - - 0.000000000000000000000000000000002875 138.0
HKD2_k127_1341027_0 Carbon starvation protein K06200 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 0.0 1079.0
HKD2_k127_1341027_1 TIGRFAM FeS assembly protein SufB K09014 - - 1.288e-270 837.0
HKD2_k127_1341027_10 PFAM OmpA MotB domain protein K02557 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 374.0
HKD2_k127_1341027_11 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 367.0
HKD2_k127_1341027_12 FeS assembly ATPase SufC K09013 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 353.0
HKD2_k127_1341027_13 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 337.0
HKD2_k127_1341027_14 Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009932 311.0
HKD2_k127_1341027_15 PFAM MotA TolQ ExbB proton channel K02556 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 295.0
HKD2_k127_1341027_16 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003669 278.0
HKD2_k127_1341027_17 PFAM peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002189 288.0
HKD2_k127_1341027_18 FeS assembly protein SufD K09015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008057 278.0
HKD2_k127_1341027_19 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000002934 255.0
HKD2_k127_1341027_2 sulphate transporter - - - 6.044e-212 674.0
HKD2_k127_1341027_20 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001374 262.0
HKD2_k127_1341027_21 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009205 247.0
HKD2_k127_1341027_23 COG1360 Flagellar motor protein K02557 - - 0.00000000000000000000000000000000000000000000000000000000000000983 228.0
HKD2_k127_1341027_24 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045454,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 0.0000000000000000000000000000000000000000000000000000008359 196.0
HKD2_k127_1341027_25 PFAM Amino acid-binding ACT K03567 - - 0.000000000000000000000000000000000000000000000000000002908 196.0
HKD2_k127_1341027_26 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.00000000000000000000000000000000000000000000000001295 183.0
HKD2_k127_1341027_27 - - - - 0.0000000000000000000000000000000000000000000000004746 186.0
HKD2_k127_1341027_28 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000000009842 143.0
HKD2_k127_1341027_29 SH3 domain K07184 - - 0.000000000000000000000000000000000000401 148.0
HKD2_k127_1341027_3 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008678 581.0
HKD2_k127_1341027_30 HIT family K02503 - - 0.000000000000000000000000000000000002006 143.0
HKD2_k127_1341027_31 transcriptional regulator - - - 0.00000000000000000000000000000000001712 140.0
HKD2_k127_1341027_32 Protein of unknown function (DUF3302) - - - 0.00000000000000000000000000001205 127.0
HKD2_k127_1341027_33 Universal stress protein K06149 - - 0.00000000000000000000000001179 115.0
HKD2_k127_1341027_34 - - - - 0.00000000000000000000000006644 116.0
HKD2_k127_1341027_35 YceI-like domain - - - 0.00000000000000000000000007596 119.0
HKD2_k127_1341027_36 Protein of unknown function (DUF1249) K09920 - - 0.0000000000000000000004758 102.0
HKD2_k127_1341027_37 COG2010 Cytochrome c, mono- and diheme variants - - - 0.0000000000000000000172 96.0
HKD2_k127_1341027_38 Selenoprotein, putative - - - 0.00000000000000007963 83.0
HKD2_k127_1341027_39 Histidine kinase K02480 - 2.7.13.3 0.00000000000003399 82.0
HKD2_k127_1341027_4 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000699 534.0
HKD2_k127_1341027_40 ATP-binding region ATPase domain protein - - - 0.0000000000435 76.0
HKD2_k127_1341027_41 Recombinase zinc beta ribbon domain - - - 0.00000003897 62.0
HKD2_k127_1341027_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005321 533.0
HKD2_k127_1341027_6 Sodium/calcium exchanger protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 504.0
HKD2_k127_1341027_7 Biotin-lipoyl like - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 452.0
HKD2_k127_1341027_8 MotA/TolQ/ExbB proton channel family K02556 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008634 437.0
HKD2_k127_1341027_9 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002296 445.0
HKD2_k127_1352514_0 Hydroxymethylglutaryl-coenzyme A reductase K00054 - 1.1.1.88 6.526e-313 976.0
HKD2_k127_1352514_1 DNA ligase (ATP) activity K01971 - 6.5.1.1 1e-266 849.0
HKD2_k127_1352514_10 Glycosyl transferase family 21 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006698 353.0
HKD2_k127_1352514_11 molybdopterin biosynthesis K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002389 309.0
HKD2_k127_1352514_12 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 300.0
HKD2_k127_1352514_13 Sulfotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006752 287.0
HKD2_k127_1352514_14 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001569 282.0
HKD2_k127_1352514_15 Molybdopterin-guanine dinucleotide biosynthesis protein B K03753 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000001166 237.0
HKD2_k127_1352514_16 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000586 225.0
HKD2_k127_1352514_17 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000567 215.0
HKD2_k127_1352514_18 Thioredoxin-like [2Fe-2S] ferredoxin K00127 - - 0.0000000000000000000000000000000000000000000000000000000000009202 217.0
HKD2_k127_1352514_19 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000001684 217.0
HKD2_k127_1352514_2 Formate dehydrogenase subunit alpha K00123 - 1.17.1.9 1.217e-263 818.0
HKD2_k127_1352514_20 TPR repeat - - - 0.0000000000000000000000000000000000000000000000008929 187.0
HKD2_k127_1352514_21 GHMP kinases N terminal domain K00938 - 2.7.4.2 0.00000000000000000000000000000000000000000003321 173.0
HKD2_k127_1352514_22 MlaC protein K07323 - - 0.000000000000000000000000004216 119.0
HKD2_k127_1352514_23 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000000000000002655 115.0
HKD2_k127_1352514_24 Phosphorylase superfamily - - - 0.00004194 54.0
HKD2_k127_1352514_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - - 3.634e-231 725.0
HKD2_k127_1352514_4 Domain of unknown function (DUF3463) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004061 598.0
HKD2_k127_1352514_5 synthase K01641,K15311 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007555 524.0
HKD2_k127_1352514_6 Exporters of the RND superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 491.0
HKD2_k127_1352514_7 Squalene phytoene synthase K00801 - 2.5.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004255 394.0
HKD2_k127_1352514_8 NmrA-like family K00091 - 1.1.1.219 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 401.0
HKD2_k127_1352514_9 GHMP kinases N terminal domain K01597 - 4.1.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 370.0
HKD2_k127_1379820_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 5.76e-247 769.0
HKD2_k127_1379820_1 Radical SAM - - - 4.838e-201 649.0
HKD2_k127_1379820_10 Putative zinc-finger - - - 0.0000000000000000000000000000000000003057 157.0
HKD2_k127_1379820_11 Flagellar motor protein K02557 - - 0.00000000000000000000000000001565 129.0
HKD2_k127_1379820_12 MotA TolQ ExbB proton channel K02556 - - 0.00000000000000000000000006523 122.0
HKD2_k127_1379820_13 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000004968 106.0
HKD2_k127_1379820_14 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00001772 56.0
HKD2_k127_1379820_3 Metallophosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 401.0
HKD2_k127_1379820_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002674 370.0
HKD2_k127_1379820_5 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000006035 218.0
HKD2_k127_1379820_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000387 194.0
HKD2_k127_1379820_7 radical SAM domain protein K06137,K06138 - 1.3.3.11 0.0000000000000000000000000000000000000000000000000000162 201.0
HKD2_k127_1379820_8 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000000000000000000000000000539 164.0
HKD2_k127_1379820_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000009869 149.0
HKD2_k127_1382994_0 ABC transporter transmembrane region K11085 - - 1.056e-280 875.0
HKD2_k127_1382994_1 Aminomethyltransferase folate-binding domain - - - 1.67e-257 808.0
HKD2_k127_1382994_10 DNA topological change K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003784 494.0
HKD2_k127_1382994_11 Bacterial sugar transferase K03606 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 472.0
HKD2_k127_1382994_12 Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor) K17763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006755 418.0
HKD2_k127_1382994_13 Thermolysin metallopeptidase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 411.0
HKD2_k127_1382994_14 pfam abc K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003023 394.0
HKD2_k127_1382994_15 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 378.0
HKD2_k127_1382994_16 aspartyl asparaginyl beta-hydroxylase K12979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002353 352.0
HKD2_k127_1382994_17 Protein of unknown function (DUF1552) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005426 350.0
HKD2_k127_1382994_18 Protein of unknown function (DUF1552) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 353.0
HKD2_k127_1382994_19 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003236 260.0
HKD2_k127_1382994_2 Belongs to the GcvT family K15066 - 2.1.1.341 4.622e-257 798.0
HKD2_k127_1382994_20 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004587 246.0
HKD2_k127_1382994_21 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000003099 236.0
HKD2_k127_1382994_22 - - - - 0.000000000000000000000000000000000000000000000000000000000006036 222.0
HKD2_k127_1382994_23 Glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000002636 224.0
HKD2_k127_1382994_24 response to abiotic stimulus K06867 - - 0.0000000000000000000000000000000000000000000000000000000193 217.0
HKD2_k127_1382994_25 - - - - 0.00000000000000000000000000000000000000000000000000000004031 214.0
HKD2_k127_1382994_26 ATP-grasp - - - 0.0000000000000000000000000000000000000000000000000000001868 210.0
HKD2_k127_1382994_27 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000001179 202.0
HKD2_k127_1382994_28 ankyrin repeat K15503 - - 0.00000000000000000000000000000000000000000000000000003269 215.0
HKD2_k127_1382994_29 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000005706 192.0
HKD2_k127_1382994_3 TIGRFAM asparagine synthase (glutamine-hydrolyzing) K01953 - 6.3.5.4 2.462e-243 772.0
HKD2_k127_1382994_30 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000007312 188.0
HKD2_k127_1382994_31 - - - - 0.00000000000000000000000000000000000000000000000009948 184.0
HKD2_k127_1382994_32 - - - - 0.000000000000000000000000000000000000000000000004791 188.0
HKD2_k127_1382994_33 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000008822 169.0
HKD2_k127_1382994_34 - - - - 0.000000000000000000000000000000000000000002337 169.0
HKD2_k127_1382994_35 PFAM Sulfate transporter antisigma-factor antagonist STAS K17762 - - 0.0000000000000000000000000000000000000006678 151.0
HKD2_k127_1382994_36 Biotin-lipoyl like K01993 - - 0.000000000000000000000000000000000000001513 163.0
HKD2_k127_1382994_37 Stage II sporulation protein - - - 0.00000000000000000000000000000000003678 147.0
HKD2_k127_1382994_38 - - - - 0.0000000000000000000000000000000004876 145.0
HKD2_k127_1382994_39 PFAM ATP-binding region, ATPase domain protein domain protein K07683 - 2.7.13.3 0.0000000000000000000000000000000006392 144.0
HKD2_k127_1382994_4 Periplasmic glucan biosynthesis protein, MdoG K03670 - - 2.884e-210 666.0
HKD2_k127_1382994_40 Histidine kinase-like ATPase domain - - - 0.00000000000000000000000000004595 121.0
HKD2_k127_1382994_41 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000001665 121.0
HKD2_k127_1382994_42 - - - - 0.00000000000000000000000001707 121.0
HKD2_k127_1382994_43 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.0000000000000000000000000268 113.0
HKD2_k127_1382994_44 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000107 122.0
HKD2_k127_1382994_45 GGDEF domain - - - 0.000000000000000000000002542 114.0
HKD2_k127_1382994_46 - - - - 0.00000000000000000000002653 107.0
HKD2_k127_1382994_47 - - - - 0.00000000000000000000002702 111.0
HKD2_k127_1382994_48 - - - - 0.000000000000000000004375 103.0
HKD2_k127_1382994_49 (twin-arginine translocation) pathway signal - - - 0.0000000000000001612 87.0
HKD2_k127_1382994_5 COG4993 Glucose dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001541 614.0
HKD2_k127_1382994_50 - - - - 0.000000000000002753 82.0
HKD2_k127_1382994_51 - - - - 0.000000000000003467 85.0
HKD2_k127_1382994_52 - - - - 0.00000000000005093 75.0
HKD2_k127_1382994_53 Cupin 2, conserved barrel domain protein - - - 0.0000000000001079 78.0
HKD2_k127_1382994_54 - - - - 0.000000000002474 77.0
HKD2_k127_1382994_55 - - - - 0.000000000004093 72.0
HKD2_k127_1382994_56 Lactoylglutathione lyase K01759 - 4.4.1.5 0.00007049 53.0
HKD2_k127_1382994_6 Pyrrolo-quinoline quinone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005432 603.0
HKD2_k127_1382994_7 DNA topological change K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002925 580.0
HKD2_k127_1382994_8 DNA topological change K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003728 540.0
HKD2_k127_1382994_9 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 520.0
HKD2_k127_1390845_0 acetolactate synthase K01652 GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 7.29e-285 888.0
HKD2_k127_1390845_1 receptor - - - 2.028e-232 745.0
HKD2_k127_1390845_10 AAA-like domain - - - 0.000000000000000000000000000000000000000000000000000000007845 228.0
HKD2_k127_1390845_11 acetolactate synthase, small K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000005135 171.0
HKD2_k127_1390845_12 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000354 166.0
HKD2_k127_1390845_13 - - - - 0.00000000001338 68.0
HKD2_k127_1390845_2 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000529 541.0
HKD2_k127_1390845_3 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006658 464.0
HKD2_k127_1390845_4 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005561 447.0
HKD2_k127_1390845_5 C-terminal domain of alpha-glycerophosphate oxidase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008891 425.0
HKD2_k127_1390845_6 PFAM peptidase M48 Ste24p - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 383.0
HKD2_k127_1390845_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005449 320.0
HKD2_k127_1390845_8 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000565 314.0
HKD2_k127_1390845_9 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001306 262.0
HKD2_k127_1428238_0 homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 1.849e-251 803.0
HKD2_k127_1428238_1 FtsX-like permease family K02004 - - 2.096e-194 638.0
HKD2_k127_1428238_10 SMART Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 413.0
HKD2_k127_1428238_11 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 406.0
HKD2_k127_1428238_12 Belongs to the arginase family K01476,K01480,K12255,K18459 - 3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006944 392.0
HKD2_k127_1428238_13 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007583 394.0
HKD2_k127_1428238_14 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 388.0
HKD2_k127_1428238_15 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000816 344.0
HKD2_k127_1428238_16 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 351.0
HKD2_k127_1428238_17 Belongs to the GST superfamily K11209 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 309.0
HKD2_k127_1428238_18 Preprotein translocase subunit TatD K03424 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 310.0
HKD2_k127_1428238_19 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000005041 243.0
HKD2_k127_1428238_2 belongs to the aldehyde dehydrogenase family K09472,K12254 - 1.2.1.54,1.2.1.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001344 613.0
HKD2_k127_1428238_20 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.00000000000000000000000000000000000000000000000000001307 203.0
HKD2_k127_1428238_21 TonB-dependent receptor, beta-barrel - - - 0.0000000000000000000000000000000000000000000001943 183.0
HKD2_k127_1428238_22 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.0000000000000000000000000000000000000000002447 174.0
HKD2_k127_1428238_23 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000005552 158.0
HKD2_k127_1428238_24 Metal-dependent hydrolase K07043 - - 0.000000000000000000000000000000000000001873 163.0
HKD2_k127_1428238_25 - - - - 0.00000000000000002351 96.0
HKD2_k127_1428238_26 Transcriptional regulator K18301 - - 0.0000000000002302 79.0
HKD2_k127_1428238_27 - - - - 0.000000000001497 75.0
HKD2_k127_1428238_28 - - - - 0.00000007173 63.0
HKD2_k127_1428238_29 Tetratricopeptide repeat - - - 0.0000003021 61.0
HKD2_k127_1428238_3 Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process K05797 - 1.17.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003559 599.0
HKD2_k127_1428238_30 Bacterial regulatory proteins, tetR family - - - 0.000189 51.0
HKD2_k127_1428238_4 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 520.0
HKD2_k127_1428238_5 Aminotransferase class-III K00819,K00821 GO:0003674,GO:0003824,GO:0004587,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.6.1.11,2.6.1.13,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 500.0
HKD2_k127_1428238_6 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001842 439.0
HKD2_k127_1428238_7 Threonine synthase K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002513 430.0
HKD2_k127_1428238_8 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 412.0
HKD2_k127_1428238_9 SMART PUA domain containing protein K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 401.0
HKD2_k127_1456054_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1196.0
HKD2_k127_1456054_1 alcohol dehydrogenase K00114 - 1.1.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008761 530.0
HKD2_k127_1456054_3 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 297.0
HKD2_k127_1456054_4 cytochrome K08738 - - 0.00000000000000000000000000000000000000000000000000007597 190.0
HKD2_k127_1456054_5 light absorption K06893 - - 0.0000000000000000000000006666 119.0
HKD2_k127_1479792_0 Pyrrolo-quinoline quinone K00114 - 1.1.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 510.0
HKD2_k127_1479792_1 ABC transporter K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 464.0
HKD2_k127_1479792_10 SnoaL-like domain - - - 0.000000000000000000000000006336 123.0
HKD2_k127_1479792_11 TonB dependent receptor K02014 - - 0.000000000002857 72.0
HKD2_k127_1479792_12 SnoaL-like domain - - - 0.00000000001587 76.0
HKD2_k127_1479792_13 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000000005049 69.0
HKD2_k127_1479792_14 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000003377 67.0
HKD2_k127_1479792_2 transport, permease protein K01992 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006072 408.0
HKD2_k127_1479792_3 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005399 369.0
HKD2_k127_1479792_4 Glucose sorbosone K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 329.0
HKD2_k127_1479792_5 Uncharacterised protein family UPF0066 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008281 306.0
HKD2_k127_1479792_6 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01576,K01652 - 2.2.1.6,4.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000597 260.0
HKD2_k127_1479792_7 - - - - 0.000000000000000000000000000000000000000000000001713 186.0
HKD2_k127_1479792_8 Domain of unknown function (DUF1932) - - - 0.0000000000000000000000000000000000000000000001701 178.0
HKD2_k127_1479792_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000003995 117.0
HKD2_k127_1513833_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 6.25e-249 778.0
HKD2_k127_1513833_1 Histidine kinase K14986 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 301.0
HKD2_k127_1513833_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000005655 250.0
HKD2_k127_1513833_3 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000002714 228.0
HKD2_k127_1513833_4 universal stress protein K14055 - - 0.000000000000000000000000000000000000000000000000019 192.0
HKD2_k127_1513833_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000756 108.0
HKD2_k127_1513833_6 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000005394 99.0
HKD2_k127_1513833_7 ribosomal large subunit export from nucleus - - - 0.0000000000003992 72.0
HKD2_k127_152213_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 5.907e-290 910.0
HKD2_k127_152213_1 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 587.0
HKD2_k127_152213_10 prohibitin homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003576 319.0
HKD2_k127_152213_11 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002703 291.0
HKD2_k127_152213_12 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K01761 - 2.5.1.48,4.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000001814 267.0
HKD2_k127_152213_13 Bacterial regulatory proteins, tetR family K16137 - - 0.00000000000000000000000000000000000000000000000002101 191.0
HKD2_k127_152213_14 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000000000000001258 181.0
HKD2_k127_152213_15 - - - - 0.00000000009083 64.0
HKD2_k127_152213_16 - - - - 0.00001018 55.0
HKD2_k127_152213_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K16871 - 2.6.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006637 548.0
HKD2_k127_152213_3 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 494.0
HKD2_k127_152213_4 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004711 466.0
HKD2_k127_152213_5 cystathione gamma lyase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 446.0
HKD2_k127_152213_6 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 438.0
HKD2_k127_152213_7 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 430.0
HKD2_k127_152213_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 385.0
HKD2_k127_152213_9 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002456 377.0
HKD2_k127_152229_0 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.21.26 1.125e-215 683.0
HKD2_k127_152229_1 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000228 267.0
HKD2_k127_152229_2 Belongs to the aldehyde dehydrogenase family K00128 GO:0003674,GO:0003824,GO:0004029,GO:0004030,GO:0006725,GO:0008150,GO:0008152,GO:0009058,GO:0009698,GO:0009699,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0019438,GO:0019748,GO:0044237,GO:0044249,GO:0044550,GO:0050269,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901576 1.2.1.3 0.0000000000000000000000000000004045 124.0
HKD2_k127_1533028_0 TonB dependent receptor - - - 8.161e-217 706.0
HKD2_k127_1533028_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 376.0
HKD2_k127_1568620_0 UPF0313 protein - - - 0.0 1074.0
HKD2_k127_1568620_1 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.664e-232 734.0
HKD2_k127_1568620_2 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 409.0
HKD2_k127_1568620_3 Protein conserved in bacteria - - - 0.00000000000000000000000005442 121.0
HKD2_k127_1568620_4 NfeD-like C-terminal, partner-binding - - - 0.00000009931 59.0
HKD2_k127_1609750_0 Uncharacterized protein conserved in bacteria (DUF2219) - - - 0.000000000000000000000000000000000000000000000000000000001809 213.0
HKD2_k127_1609750_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000004284 203.0
HKD2_k127_1609750_2 Signal transduction protein - - - 0.00000000000000000000000000000006505 131.0
HKD2_k127_1609750_3 DnaJ molecular chaperone homology domain - - - 0.00000000000000000000005771 108.0
HKD2_k127_1609750_4 PhzC PhzF - - - 0.000007936 57.0
HKD2_k127_1759019_0 Uncharacterised conserved protein (DUF2156) K07027,K14205 - 2.3.2.3 7.087e-242 777.0
HKD2_k127_1759019_1 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.177e-198 633.0
HKD2_k127_1759019_10 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001355 232.0
HKD2_k127_1759019_11 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000005889 211.0
HKD2_k127_1759019_12 Bacterial virulence protein (VirJ) - - - 0.0000000000000000000000000000000000000000000003464 175.0
HKD2_k127_1759019_13 - - - - 0.00000000000000000000000000000000000000000001706 172.0
HKD2_k127_1759019_14 Hsp20/alpha crystallin family - - - 0.0000000000000000000000000000000000000000004462 164.0
HKD2_k127_1759019_15 - - - - 0.000000000000000000000000000000000000000002228 170.0
HKD2_k127_1759019_16 Cupin superfamily (DUF985) K09705 - - 0.00000000000000000000000000000000000000007411 156.0
HKD2_k127_1759019_17 Transposase K07486 - - 0.0000000000000000000000000000000000000005371 156.0
HKD2_k127_1759019_18 - - - - 0.00000000000000000000000000000000000005476 150.0
HKD2_k127_1759019_19 Glyoxalase-like domain - - - 0.0000000000000000000000000000000000001118 147.0
HKD2_k127_1759019_2 Lysin motif K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 584.0
HKD2_k127_1759019_20 Hsp20/alpha crystallin family - - - 0.0000000000000000000000000001056 119.0
HKD2_k127_1759019_22 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000001038 91.0
HKD2_k127_1759019_23 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000001161 84.0
HKD2_k127_1759019_24 Transposase IS116/IS110/IS902 family K07486 - - 0.0000000000000006085 82.0
HKD2_k127_1759019_25 Cellulase (glycosyl hydrolase family 5) - - - 0.000000000000003705 79.0
HKD2_k127_1759019_26 secretion system protein K02453 - - 0.0000000000001412 79.0
HKD2_k127_1759019_27 COGs COG5616 integral membrane protein - - - 0.0000004204 63.0
HKD2_k127_1759019_28 SnoaL-like domain - - - 0.0002885 53.0
HKD2_k127_1759019_3 PQQ-like domain K05889 - 1.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002419 522.0
HKD2_k127_1759019_4 Creatinase/Prolidase N-terminal domain K08688 - 3.5.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009785 473.0
HKD2_k127_1759019_5 Ferredoxin-fold anticodon binding domain K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002935 423.0
HKD2_k127_1759019_6 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 437.0
HKD2_k127_1759019_7 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 353.0
HKD2_k127_1759019_8 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009567 310.0
HKD2_k127_1759019_9 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000001833 252.0
HKD2_k127_1807881_0 Part of a membrane complex involved in electron transport K03615 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 370.0
HKD2_k127_1807881_2 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000000000000000000000000003818 194.0
HKD2_k127_1807881_3 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000009155 151.0
HKD2_k127_1819268_0 efflux transmembrane transporter activity - - - 2.005e-198 646.0
HKD2_k127_1819268_1 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002105 556.0
HKD2_k127_1819268_10 Domain of unknown function (DUF4124) - - - 0.000001311 56.0
HKD2_k127_1819268_2 Among the AAA ATPases, the YifB protease family belongs to the Helix 2 insert clade K07391 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 478.0
HKD2_k127_1819268_3 signal transduction protein with a C-terminal ATPase domain K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001371 286.0
HKD2_k127_1819268_4 Response regulator of the LytR AlgR family K08083 - - 0.000000000000000000000000000000000000000000000000000000000000000009395 246.0
HKD2_k127_1819268_5 Antibiotic biosynthesis monooxygenase - - - 0.0000000000000000000000000000000337 129.0
HKD2_k127_1819268_6 COG3245 Cytochrome c5 K02277 - 1.9.3.1 0.000000000000000000000001954 109.0
HKD2_k127_1819268_7 Membrane fusogenic activity K09806 - - 0.00000000000000002815 83.0
HKD2_k127_1819268_8 enzyme of heme biosynthesis K02496,K13543 - 2.1.1.107,4.2.1.75 0.000000000000001786 86.0
HKD2_k127_1819268_9 OmpA-like transmembrane domain - - - 0.0000000000000133 82.0
HKD2_k127_1856329_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 1.991e-215 692.0
HKD2_k127_1856329_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 543.0
HKD2_k127_1856329_10 phosphatase K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003535 284.0
HKD2_k127_1856329_11 FeS assembly SUF system protein SufT - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003579 256.0
HKD2_k127_1856329_12 TRAP transporter T-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006356 256.0
HKD2_k127_1856329_13 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000000009155 238.0
HKD2_k127_1856329_14 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000000000000000000000000000000000002335 227.0
HKD2_k127_1856329_15 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000000000000000003057 184.0
HKD2_k127_1856329_16 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000000000000000001099 185.0
HKD2_k127_1856329_17 binds to the 23S rRNA K02939 - - 0.00000000000000000000000000000000000000000000000003987 182.0
HKD2_k127_1856329_18 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000000000000000000000000001312 162.0
HKD2_k127_1856329_19 Histidine phosphatase superfamily (branch 1) K08296 - - 0.0000000000000000000000000000000000001126 148.0
HKD2_k127_1856329_2 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000172 528.0
HKD2_k127_1856329_20 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000008106 139.0
HKD2_k127_1856329_22 Belongs to the bacterial ribosomal protein bS16 family K02959 GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000002271 118.0
HKD2_k127_1856329_23 PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - 0.00000000000000000000000007559 114.0
HKD2_k127_1856329_24 PFAM RNA-binding S4 domain protein K04762 - - 0.0000000000000000000000004644 111.0
HKD2_k127_1856329_25 SUF system FeS assembly protein K04488 - - 0.000003682 48.0
HKD2_k127_1856329_26 membrane - - - 0.00008539 53.0
HKD2_k127_1856329_27 Site-specific recombinase, DNA invertase Pin - - - 0.00008835 48.0
HKD2_k127_1856329_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004668 490.0
HKD2_k127_1856329_4 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 492.0
HKD2_k127_1856329_5 signal peptide peptidase K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 464.0
HKD2_k127_1856329_6 CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006931 436.0
HKD2_k127_1856329_7 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008377 353.0
HKD2_k127_1856329_8 carbohydrate transport K11688,K21395 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 313.0
HKD2_k127_1856329_9 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 307.0
HKD2_k127_193325_0 Belongs to the glycosyl hydrolase 3 family K05349 - 3.2.1.21 7.514e-227 719.0
HKD2_k127_193325_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 607.0
HKD2_k127_193325_2 - - - - 0.0000000000000000000000000000000000000000000000000000000004779 210.0
HKD2_k127_193325_3 Protein of unknown function (DUF1232) - - - 0.000000000000000000000000000000000000117 149.0
HKD2_k127_193325_4 pyridoxamine 5-phosphate - - - 0.0000000000000000000000000000000000001281 149.0
HKD2_k127_193325_5 Transcriptional regulator K07727 - - 0.000000000000000000000000002276 112.0
HKD2_k127_193325_6 Amidohydrolase family K01465 - 3.5.2.3 0.000000000000000000000005965 110.0
HKD2_k127_193325_7 FAD binding domain - - - 0.0000000000000000004055 98.0
HKD2_k127_193325_8 Protein of unknown function (DUF2975) - - - 0.000000000000006998 81.0
HKD2_k127_2020982_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 572.0
HKD2_k127_2020982_1 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 400.0
HKD2_k127_2020982_2 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007903 285.0
HKD2_k127_2020982_3 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000001371 175.0
HKD2_k127_2020982_4 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.00000000000000000000000000000000000003079 147.0
HKD2_k127_2020982_5 electron transfer activity K00428 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.5 0.00000000000000000000000000000000007039 150.0
HKD2_k127_2057698_0 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 522.0
HKD2_k127_2057698_1 Thioredoxin K03672 - 1.8.1.8 0.00000000000000000000000000000000000000000000003527 196.0
HKD2_k127_2057698_2 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000001725 147.0
HKD2_k127_2057698_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000001643 89.0
HKD2_k127_2074219_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 433.0
HKD2_k127_2074219_1 NmrA-like family K19267 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007196 329.0
HKD2_k127_2074219_2 Putative neutral zinc metallopeptidase K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 316.0
HKD2_k127_2074219_3 NnrU protein - - - 0.000000000000000000000000000000000000000000000000000000005596 204.0
HKD2_k127_2074219_4 Redoxin - - - 0.000000000000000000000000000000002269 130.0
HKD2_k127_2074219_5 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000009558 133.0
HKD2_k127_2074219_6 - - - - 0.0000000000000000000000222 107.0
HKD2_k127_2081923_0 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004811 295.0
HKD2_k127_2081923_1 iron ion binding - - - 0.000000000000000000000000000000000000000000797 167.0
HKD2_k127_2081923_2 acetyltransferase - - - 0.000000000000000000000000000000000000002302 166.0
HKD2_k127_2081923_3 iron ion binding - - - 0.0000000000000000000003252 98.0
HKD2_k127_2081923_4 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000004075 111.0
HKD2_k127_2081923_5 Tetracyclin repressor, C-terminal all-alpha domain - - - 0.000000000000000006414 87.0
HKD2_k127_2224212_0 efflux pump K18138,K18322 - - 0.0 1385.0
HKD2_k127_2224212_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.0 1244.0
HKD2_k127_2224212_10 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 433.0
HKD2_k127_2224212_11 PFAM PhoH family protein K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 407.0
HKD2_k127_2224212_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 405.0
HKD2_k127_2224212_13 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 401.0
HKD2_k127_2224212_14 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 389.0
HKD2_k127_2224212_15 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005872 407.0
HKD2_k127_2224212_16 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008511 380.0
HKD2_k127_2224212_17 UDP-glucoronosyl and UDP-glucosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 368.0
HKD2_k127_2224212_18 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 323.0
HKD2_k127_2224212_19 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K03185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 347.0
HKD2_k127_2224212_2 PDZ-like domain - - - 4.973e-232 750.0
HKD2_k127_2224212_20 Type II secretory pathway component ExeA K02450,K12283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000392 316.0
HKD2_k127_2224212_21 PFAM Glutamine cyclotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 300.0
HKD2_k127_2224212_22 PFAM CBS domain K06189 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 296.0
HKD2_k127_2224212_23 TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 K18800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001804 295.0
HKD2_k127_2224212_24 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001283 277.0
HKD2_k127_2224212_25 UPF0761 membrane protein K07058 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000159 274.0
HKD2_k127_2224212_26 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000001978 266.0
HKD2_k127_2224212_27 DNA polymerase III, delta subunit K02340 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000004217 274.0
HKD2_k127_2224212_28 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000664 273.0
HKD2_k127_2224212_29 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000001177 247.0
HKD2_k127_2224212_3 Protein of unknown function, DUF255 K06888 - - 5.319e-227 723.0
HKD2_k127_2224212_30 PFAM SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003884 248.0
HKD2_k127_2224212_31 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000002743 235.0
HKD2_k127_2224212_32 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000000000000000000000001972 243.0
HKD2_k127_2224212_33 EVE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001374 228.0
HKD2_k127_2224212_34 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000000000000001101 227.0
HKD2_k127_2224212_35 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.0000000000000000000000000000000000000000000000000000000000001531 218.0
HKD2_k127_2224212_36 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000002582 224.0
HKD2_k127_2224212_37 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000000000002811 204.0
HKD2_k127_2224212_38 Belongs to the universal ribosomal protein uS9 family K02996 GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000005225 200.0
HKD2_k127_2224212_39 Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host K05801 - - 0.000000000000000000000000000000000000000000000000000000005575 208.0
HKD2_k127_2224212_4 Responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase K03568 - - 9.379e-197 624.0
HKD2_k127_2224212_40 - - - - 0.00000000000000000000000000000000000000000000000000002986 194.0
HKD2_k127_2224212_41 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000003996 194.0
HKD2_k127_2224212_42 C-terminus of AA_permease K03294 - - 0.000000000000000000000000000000000000000000000000002108 186.0
HKD2_k127_2224212_43 TIGRFAM histidinol-phosphate phosphatase HisN, inositol monophosphatase family K01092,K05602 - 3.1.3.15,3.1.3.25 0.000000000000000000000000000000000000000000000002329 184.0
HKD2_k127_2224212_44 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000000000005372 169.0
HKD2_k127_2224212_45 CAAX protease self-immunity - - - 0.000000000000000000000000000000000000000001125 167.0
HKD2_k127_2224212_46 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000005131 158.0
HKD2_k127_2224212_47 Belongs to the UPF0145 family - - - 0.000000000000000000000000000000000000000006752 165.0
HKD2_k127_2224212_48 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000000000008349 151.0
HKD2_k127_2224212_49 transcriptional - - - 0.0000000000000000000000000000000001305 138.0
HKD2_k127_2224212_5 TIGRFAM ribonuclease, Rne Rng family K08301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000852 616.0
HKD2_k127_2224212_50 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 - 0.000000000000000000000000000000001553 135.0
HKD2_k127_2224212_51 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000001924 129.0
HKD2_k127_2224212_52 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000007956 111.0
HKD2_k127_2224212_53 - - - - 0.0000000000000000000000003194 110.0
HKD2_k127_2224212_54 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000001582 102.0
HKD2_k127_2224212_55 Protein of unknown function, DUF255 K01829 - 5.3.4.1 0.00000000000000000000877 108.0
HKD2_k127_2224212_56 Belongs to the UPF0149 family K09895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000007928 98.0
HKD2_k127_2224212_57 Trm112p-like protein - - - 0.00000000000000004444 89.0
HKD2_k127_2224212_58 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - 0.0000000000000000526 89.0
HKD2_k127_2224212_59 TIGRFAM TIGR02449 family protein K09892 - - 0.00000000008097 65.0
HKD2_k127_2224212_6 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 601.0
HKD2_k127_2224212_60 salt-induced outer membrane protein K07283 - - 0.0000000007488 69.0
HKD2_k127_2224212_61 WD-40 repeat-containing protein - - - 0.00003431 57.0
HKD2_k127_2224212_7 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003456 562.0
HKD2_k127_2224212_8 peptidase M24B, X-Pro dipeptidase aminopeptidase K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 561.0
HKD2_k127_2224212_9 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000541 451.0
HKD2_k127_2378591_0 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365 - 2.4.1.129,3.4.16.4 2.83e-215 692.0
HKD2_k127_2378591_1 Parallel beta-helix repeats - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 594.0
HKD2_k127_2378591_2 Amidinotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001018 254.0
HKD2_k127_2378591_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000001072 254.0
HKD2_k127_2378591_4 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000001176 249.0
HKD2_k127_2378591_5 EF-hand domain pair - - - 0.0000001953 64.0
HKD2_k127_2378591_6 Tetratricopeptide repeat - - - 0.00008002 55.0
HKD2_k127_245881_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 456.0
HKD2_k127_245881_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000001 266.0
HKD2_k127_245881_2 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000002834 237.0
HKD2_k127_245881_3 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000000000000000000000000000000002554 241.0
HKD2_k127_245881_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000001108 214.0
HKD2_k127_245881_5 Endonuclease Exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000004433 176.0
HKD2_k127_245881_6 Indole-3-glycerol phosphate synthase K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.000000000000000000000000000000000001197 156.0
HKD2_k127_245881_7 N-(5'phosphoribosyl)anthranilate (PRA) isomerase K01817 - 5.3.1.24 0.000000000000000000000000000005517 134.0
HKD2_k127_245881_8 Putative prokaryotic signal transducing protein - - - 0.000000000000000005976 90.0
HKD2_k127_2562563_0 AcrB/AcrD/AcrF family - - - 0.0 1265.0
HKD2_k127_2562563_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009109 415.0
HKD2_k127_2562563_10 outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000002705 190.0
HKD2_k127_2562563_11 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000001965 176.0
HKD2_k127_2562563_12 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000001434 161.0
HKD2_k127_2562563_13 - - - - 0.00000000000000000000000000000000000004608 147.0
HKD2_k127_2562563_14 Serine threonine protein kinase - - - 0.0000000000000000000000000000000007135 151.0
HKD2_k127_2562563_15 Ankyrin repeat domain protein - - - 0.000000000000000000000000000003822 137.0
HKD2_k127_2562563_16 - - - - 0.000000000003529 72.0
HKD2_k127_2562563_2 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 402.0
HKD2_k127_2562563_3 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005333 398.0
HKD2_k127_2562563_4 Tfp pilus assembly protein FimV - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003781 365.0
HKD2_k127_2562563_6 long-chain fatty acid transporting porin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001185 271.0
HKD2_k127_2562563_7 Transcriptional regulatory protein, C terminal K07669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003476 244.0
HKD2_k127_2562563_8 Carboxylesterase family - - - 0.000000000000000000000000000000000000000000000000000000000002312 238.0
HKD2_k127_2562563_9 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.000000000000000000000000000000000000000000000002418 177.0
HKD2_k127_2565516_0 AcrB/AcrD/AcrF family K03296,K07788,K07789,K21133 - - 0.0 1066.0
HKD2_k127_2565516_1 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 5.609e-240 746.0
HKD2_k127_2565516_10 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000002715 238.0
HKD2_k127_2565516_11 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses K01077 - 3.1.3.1 0.0000000000000000000000003114 122.0
HKD2_k127_2565516_12 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000005095 103.0
HKD2_k127_2565516_13 - - - - 0.000000000001504 68.0
HKD2_k127_2565516_2 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 9.199e-201 632.0
HKD2_k127_2565516_3 Pyridine nucleotide-disulphide oxidoreductase K07222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001356 576.0
HKD2_k127_2565516_4 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005013 425.0
HKD2_k127_2565516_5 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 406.0
HKD2_k127_2565516_6 C-terminal domain of 1-Cys peroxiredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004261 376.0
HKD2_k127_2565516_7 OsmC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001221 262.0
HKD2_k127_2565516_8 CoA binding domain K06929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002824 263.0
HKD2_k127_2565516_9 3-Demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000008622 232.0
HKD2_k127_2585701_0 in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004734 282.0
HKD2_k127_2585701_1 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000201 262.0
HKD2_k127_2585701_2 Dihydroxyacetone kinase, L subunit K05879 - 2.7.1.121 0.0000000000000000000000000000000000000000000000000000004224 204.0
HKD2_k127_2585701_3 Dihydroxyacetone kinase K00863,K05878 - 2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15 0.000000000000000000000000000000000000000000000000000723 186.0
HKD2_k127_2612696_0 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 340.0
HKD2_k127_2612696_1 COG1131 ABC-type multidrug transport system, ATPase component K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000009395 213.0
HKD2_k127_2612696_2 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000000000006489 174.0
HKD2_k127_2630879_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004607 490.0
HKD2_k127_2630879_1 Sugar (and other) transporter K08195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 466.0
HKD2_k127_2630879_10 Domain of unknown function (DUF1993) K09983 - - 0.000000000000000000000000000000000000000000000000000004608 196.0
HKD2_k127_2630879_11 Pfam:DUF2029 - - - 0.000000000000000000000000000000000000000000006991 183.0
HKD2_k127_2630879_12 Conserved TM helix - - - 0.000000000000000000000000000000000000000002019 173.0
HKD2_k127_2630879_13 MgtE intracellular N domain - - - 0.000000000000000000000001737 115.0
HKD2_k127_2630879_14 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.000000000000000000127 93.0
HKD2_k127_2630879_15 Methyltransferase domain - - - 0.00000000000007144 72.0
HKD2_k127_2630879_2 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 412.0
HKD2_k127_2630879_3 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 403.0
HKD2_k127_2630879_4 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 370.0
HKD2_k127_2630879_5 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008742 348.0
HKD2_k127_2630879_6 Glycosyltransferase like family 2 K20534 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008372 336.0
HKD2_k127_2630879_7 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007368 274.0
HKD2_k127_2630879_8 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000001019 226.0
HKD2_k127_2630879_9 involved in outer membrane biogenesis K07289 - - 0.00000000000000000000000000000000000000000000000000000000000000334 249.0
HKD2_k127_2648374_0 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 464.0
HKD2_k127_2648374_1 Protein of unknown function (DUF1552) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 297.0
HKD2_k127_2648374_2 Ankyrin repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004295 260.0
HKD2_k127_2668232_0 aminotransferase K14260 - 2.6.1.2,2.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001482 494.0
HKD2_k127_2668232_1 Electron transfer flavoprotein K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 336.0
HKD2_k127_2668232_2 electron transfer flavoprotein beta subunit K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 315.0
HKD2_k127_2668232_3 sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006277 289.0
HKD2_k127_2668232_4 PD-(D/E)XK nuclease superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009852 277.0
HKD2_k127_2668232_5 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582 - 3.1.11.5 0.000000000000000000000000003732 120.0
HKD2_k127_2699740_0 N-terminal TM domain of oligopeptide transport permease C K02034,K12370 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000818 453.0
HKD2_k127_2699740_1 PFAM binding-protein-dependent transport systems inner membrane component K02033,K12369 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008191 259.0
HKD2_k127_2699740_2 Belongs to the ABC transporter superfamily K02031,K12371 - - 0.00000000000000000000000000000000000000000000000000000000004722 206.0
HKD2_k127_2699740_3 - - - - 0.00001111 55.0
HKD2_k127_2700466_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 1289.0
HKD2_k127_2700466_1 PFAM glycoside hydrolase, family 3 domain protein K05349 - 3.2.1.21 1.898e-319 992.0
HKD2_k127_2700466_10 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007543 625.0
HKD2_k127_2700466_11 beta-keto acid cleavage enzyme K18013 - 2.3.1.247 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 526.0
HKD2_k127_2700466_12 amino acid peptide transporter K03305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005065 512.0
HKD2_k127_2700466_13 Tannase and feruloyl esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002907 528.0
HKD2_k127_2700466_14 Glycosyl hydrolases family 15 K01178 - 3.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 525.0
HKD2_k127_2700466_15 Cupin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001402 448.0
HKD2_k127_2700466_16 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 451.0
HKD2_k127_2700466_17 gag-polyprotein putative aspartyl protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004784 460.0
HKD2_k127_2700466_18 Protein of unknown function (DUF1552) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 435.0
HKD2_k127_2700466_19 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008338 407.0
HKD2_k127_2700466_2 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K20940 - 1.14.13.218 5.636e-222 696.0
HKD2_k127_2700466_20 ankyrin repeat K15503 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007569 416.0
HKD2_k127_2700466_21 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007241 358.0
HKD2_k127_2700466_22 Sugar (and other) transporter K08195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 359.0
HKD2_k127_2700466_23 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000297 331.0
HKD2_k127_2700466_24 2-keto-3-deoxy-galactonokinase K00883 - 2.7.1.58 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 329.0
HKD2_k127_2700466_25 Ankyrin repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 314.0
HKD2_k127_2700466_26 Alpha/beta hydrolase family K01561 - 3.8.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001183 281.0
HKD2_k127_2700466_27 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000065 274.0
HKD2_k127_2700466_28 KDPG and KHG aldolase K01631 - 4.1.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000005762 258.0
HKD2_k127_2700466_29 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000001499 244.0
HKD2_k127_2700466_3 SbmA/BacA-like family - - - 4.218e-220 700.0
HKD2_k127_2700466_30 GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000003228 243.0
HKD2_k127_2700466_31 Amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000005523 213.0
HKD2_k127_2700466_32 Melibiase K07407 - 3.2.1.22 0.000000000000000000000000000000000000000000000000000000003876 226.0
HKD2_k127_2700466_33 - - - - 0.0000000000000000000000000000000000000000000000000003434 205.0
HKD2_k127_2700466_34 Phosphatidylethanolamine-binding protein - - - 0.0000000000000000000000000000000000000000001959 166.0
HKD2_k127_2700466_35 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000007496 172.0
HKD2_k127_2700466_36 gluconolactonase activity K01053 - 3.1.1.17 0.00000000000000000000000000000000000000002054 164.0
HKD2_k127_2700466_37 - - - - 0.000000000000000000000000000000000002372 151.0
HKD2_k127_2700466_38 - - - - 0.0000000000000000000000000000002339 137.0
HKD2_k127_2700466_4 ABC transporter C-terminal domain K15738 - - 2.74e-219 698.0
HKD2_k127_2700466_40 - - - - 0.000000000000000000000000002846 117.0
HKD2_k127_2700466_41 - - - - 0.000000000000000000006441 97.0
HKD2_k127_2700466_43 - - - - 0.00000000000000002249 88.0
HKD2_k127_2700466_44 intracellular protease amidase K05520 - 3.5.1.124 0.0000000000009754 74.0
HKD2_k127_2700466_46 SnoaL-like domain - - - 0.000006697 56.0
HKD2_k127_2700466_5 SbmA/BacA-like family - - - 5.95e-215 689.0
HKD2_k127_2700466_6 Putative glucoamylase - - - 5.285e-212 669.0
HKD2_k127_2700466_7 DNA topological change K03168 - 5.99.1.2 8.817e-207 668.0
HKD2_k127_2700466_8 4-hydroxybenzoate 3-monooxygenase K00481 - 1.14.13.2 9.517e-205 644.0
HKD2_k127_2700466_9 Protein of unknown function (DUF1587) - - - 6.133e-194 631.0
HKD2_k127_2726507_0 PQQ-like domain K00117 - 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 591.0
HKD2_k127_2726507_1 Carboxylesterase family K03929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 388.0
HKD2_k127_2726507_10 - - - - 0.00000008229 64.0
HKD2_k127_2726507_2 Phosphate-selective porin O and P - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 367.0
HKD2_k127_2726507_3 Cysteine-rich domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 342.0
HKD2_k127_2726507_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001339 271.0
HKD2_k127_2726507_5 - - - - 0.00000000000000000000000000000000000006699 156.0
HKD2_k127_2726507_6 FMN-binding domain protein - - - 0.0000000000000000000000000000000000004972 151.0
HKD2_k127_2726507_7 - - - - 0.0000000000000000000000000000000000013 142.0
HKD2_k127_2726507_8 Dehydrogenase K00117 - 1.1.5.2 0.000000000000000000000000000000003941 132.0
HKD2_k127_2726507_9 ApbE family - - - 0.0000000000000000000000000000164 128.0
HKD2_k127_2758418_0 2 iron, 2 sulfur cluster binding - - - 0.0 1628.0
HKD2_k127_2758418_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1350.0
HKD2_k127_2758418_10 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006841 284.0
HKD2_k127_2758418_11 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000003748 267.0
HKD2_k127_2758418_12 RibD C-terminal domain K00082,K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000579 245.0
HKD2_k127_2758418_13 6-pyruvoyl tetrahydropterin synthase - - - 0.0000000000000000000000000000000000000000000000000000000002247 205.0
HKD2_k127_2758418_14 protein-(glutamine-N5) methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000001921 213.0
HKD2_k127_2758418_15 Belongs to the ompA family - - - 0.0000000000000000000000000000000000000000000000000000001841 210.0
HKD2_k127_2758418_16 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000000000000000000000000000000000000000000000001415 196.0
HKD2_k127_2758418_17 COG1047 FKBP-type peptidyl-prolyl cis-trans isomerases 2 K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000000009022 183.0
HKD2_k127_2758418_18 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.0000000000000000000000000000000000000003919 161.0
HKD2_k127_2758418_19 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.0000000000000000000000000000000000006944 152.0
HKD2_k127_2758418_2 COG0243 Anaerobic dehydrogenases, typically selenocysteine-containing - - - 0.0 1094.0
HKD2_k127_2758418_20 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000004368 144.0
HKD2_k127_2758418_21 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000003875 126.0
HKD2_k127_2758418_3 Bacterial protein of unknown function (DUF885) - - - 2.056e-227 720.0
HKD2_k127_2758418_4 Aldehyde dehydrogenase family K13922,K18119 - 1.2.1.76,1.2.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 541.0
HKD2_k127_2758418_5 PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B K04099 - 1.13.11.57 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 535.0
HKD2_k127_2758418_6 transmembrane transporter activity K13021 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002468 435.0
HKD2_k127_2758418_7 COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 412.0
HKD2_k127_2758418_8 Putative vitamin uptake transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000925 360.0
HKD2_k127_2758418_9 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003895 329.0
HKD2_k127_2806572_0 Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA K01638 - 2.3.3.9 9.612e-297 931.0
HKD2_k127_2806572_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 2.126e-290 915.0
HKD2_k127_2806572_10 OsmC-like protein K04063 - - 0.0000000000000000000000000000000000000000000002513 171.0
HKD2_k127_2806572_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 4.885e-266 833.0
HKD2_k127_2806572_3 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 601.0
HKD2_k127_2806572_4 Magnesium transport protein CorA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007517 567.0
HKD2_k127_2806572_5 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0042254,GO:0042255,GO:0042623,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0065003,GO:0070035,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 517.0
HKD2_k127_2806572_6 Histidine kinase K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000214 519.0
HKD2_k127_2806572_7 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005319 483.0
HKD2_k127_2806572_8 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007013 258.0
HKD2_k127_2806572_9 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000002947 228.0
HKD2_k127_2820950_0 Prolyl oligopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 375.0
HKD2_k127_2820950_2 photoreceptor activity - - - 0.000000000000006419 74.0
HKD2_k127_2820950_3 Histidine kinase - - - 0.0000000000005176 70.0
HKD2_k127_2868460_0 glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1452.0
HKD2_k127_2868460_1 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 2.175e-220 693.0
HKD2_k127_2868460_10 Major facilitator K05819,K08195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001221 399.0
HKD2_k127_2868460_11 Acyl-CoA thioesterase K10805 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005913 345.0
HKD2_k127_2868460_12 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001243 340.0
HKD2_k127_2868460_13 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 329.0
HKD2_k127_2868460_14 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019693,GO:0019752,GO:0020037,GO:0022607,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 326.0
HKD2_k127_2868460_15 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003268 266.0
HKD2_k127_2868460_16 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000000000000000000000000000005445 248.0
HKD2_k127_2868460_17 Cytochrome C oxidase, mono-heme subunit/FixO K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001629 250.0
HKD2_k127_2868460_18 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000003152 238.0
HKD2_k127_2868460_19 Putative restriction endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000004809 244.0
HKD2_k127_2868460_2 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000612 617.0
HKD2_k127_2868460_20 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000000000006149 195.0
HKD2_k127_2868460_21 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000001052 208.0
HKD2_k127_2868460_22 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000000000005536 194.0
HKD2_k127_2868460_23 PFAM molybdopterin biosynthesis MoaE protein K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000000001379 184.0
HKD2_k127_2868460_24 nicotinamide mononucleotide transporter K03811 - - 0.00000000000000000000000000000000000000000000001193 192.0
HKD2_k127_2868460_25 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.0000000000000000000000000000000000000000000007408 168.0
HKD2_k127_2868460_26 Auxin binding protein - - - 0.00000000000000000000000000000001903 131.0
HKD2_k127_2868460_27 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000004875 126.0
HKD2_k127_2868460_28 MobA-Related Protein K00087,K07141,K07402,K19190 - 1.1.1.328,1.17.1.4,2.7.7.76 0.00000000000000000000000008728 117.0
HKD2_k127_2868460_29 Membrane - GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - 0.000000000000000000000009803 109.0
HKD2_k127_2868460_3 TonB-dependent receptor plug K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 554.0
HKD2_k127_2868460_30 Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway K15521 - 2.4.1.250 0.0000000000000000000007593 109.0
HKD2_k127_2868460_31 Choline kinase - - - 0.0000000000002159 83.0
HKD2_k127_2868460_32 YKOF-related Family - - - 0.0000000000003939 72.0
HKD2_k127_2868460_33 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000000003087 68.0
HKD2_k127_2868460_4 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 468.0
HKD2_k127_2868460_5 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 437.0
HKD2_k127_2868460_6 Predicted membrane protein (DUF2339) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 444.0
HKD2_k127_2868460_7 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004441 415.0
HKD2_k127_2868460_8 Phosphoesterase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006169 413.0
HKD2_k127_2868460_9 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003466 404.0
HKD2_k127_2873935_0 Protein of unknown function (DUF1624) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 400.0
HKD2_k127_2873935_1 Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 350.0
HKD2_k127_2873935_2 Cytochrome c K10535 - 1.7.2.6 0.0001291 46.0
HKD2_k127_2914972_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 1.045e-245 773.0
HKD2_k127_2914972_1 PFAM aminoacyl-tRNA synthetase class Ib K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 434.0
HKD2_k127_2914972_2 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 338.0
HKD2_k127_2914972_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.000000000000000000000000000000000000000000000000000000001294 215.0
HKD2_k127_2914972_4 Protein of unknown function (DUF1097) - - - 0.00000000000000000000000000000000000000000000000009405 183.0
HKD2_k127_2914972_5 Glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.000000000000000000000000000000009853 132.0
HKD2_k127_2914972_6 Amidohydrolase family - - - 0.00000000000000000000009343 111.0
HKD2_k127_2914972_7 - - - - 0.00000000000006988 75.0
HKD2_k127_296419_0 Retinal pigment epithelial membrane protein K11159 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 383.0
HKD2_k127_296419_1 2OG-Fe(II) oxygenase superfamily K03919 - 1.14.11.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003907 280.0
HKD2_k127_296419_4 - - - - 0.000000000000004139 81.0
HKD2_k127_3064353_0 Heavy metal translocating P-type atpase K17686 - 3.6.3.54 7.006e-277 873.0
HKD2_k127_3064353_1 Multi-copper - - - 2.151e-242 782.0
HKD2_k127_3064353_2 copper resistance K07233 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004242 249.0
HKD2_k127_3064353_3 helix_turn_helix, mercury resistance K19591 - - 0.0000000000000000000000000000000000000000004249 162.0
HKD2_k127_3064353_4 FAD binding domain - - - 0.0000000000000000000000000000000000004603 147.0
HKD2_k127_3064353_5 Protein of unknown function (DUF1090) - - - 0.00000000000000000000000001119 115.0
HKD2_k127_3064353_6 - - - - 0.0000000000000000000000001504 113.0
HKD2_k127_3064353_7 Metallo-beta-lactamase superfamily - - - 0.0000000002226 66.0
HKD2_k127_3064353_8 - - - - 0.0000009131 57.0
HKD2_k127_3067471_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.222e-306 955.0
HKD2_k127_3067471_1 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 3.565e-268 851.0
HKD2_k127_3067471_10 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) K01826 - 5.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 340.0
HKD2_k127_3067471_11 SEC-C Motif Domain Protein - - - 0.0000000000000000000000000000000000000000000000000007457 192.0
HKD2_k127_3067471_12 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.000000000000000000000000000000000000000000002749 167.0
HKD2_k127_3067471_13 endonuclease activity - - - 0.0000000000000000000000000000000001089 144.0
HKD2_k127_3067471_14 5-carboxymethyl-2-hydroxymuconate isomerase K01826 - 5.3.3.10 0.0000000000000000000000000000001024 129.0
HKD2_k127_3067471_15 COG3901 Regulator of nitric oxide reductase transcription K19339 - - 0.00000000000000000000000000007384 126.0
HKD2_k127_3067471_16 Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - - 0.0000000000000000000000000002682 128.0
HKD2_k127_3067471_17 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000004895 55.0
HKD2_k127_3067471_2 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01200,K01214 - 3.2.1.41,3.2.1.68 1.11e-244 773.0
HKD2_k127_3067471_3 Belongs to the aldehyde dehydrogenase family K00151 - 1.2.1.60 7.012e-218 690.0
HKD2_k127_3067471_4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007359 559.0
HKD2_k127_3067471_5 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 460.0
HKD2_k127_3067471_6 Surface antigen variable number K07278 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 453.0
HKD2_k127_3067471_7 PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B K04101,K05713 - 1.13.11.16,1.13.11.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004759 417.0
HKD2_k127_3067471_8 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 389.0
HKD2_k127_3067471_9 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 404.0
HKD2_k127_3111022_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1013.0
HKD2_k127_3111022_1 Phosphoesterase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002158 551.0
HKD2_k127_3111022_2 DNA photolyase K01669 GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0019222,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 525.0
HKD2_k127_3111022_3 Di-haem cytochrome c peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 489.0
HKD2_k127_3111022_4 PFAM Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 411.0
HKD2_k127_3111022_5 COG1194 A G-specific DNA glycosylase K03575 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 308.0
HKD2_k127_3111022_6 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000001139 254.0
HKD2_k127_3111022_7 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000004137 170.0
HKD2_k127_3111022_8 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.000000000000000000000000000000000003897 149.0
HKD2_k127_3165912_0 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004294 503.0
HKD2_k127_3165912_1 ATPase family associated with various cellular activities (AAA) K01338 - 3.4.21.53 0.0000000000000000001653 89.0
HKD2_k127_3166963_0 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008753 522.0
HKD2_k127_3166963_1 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 345.0
HKD2_k127_3183046_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1116.0
HKD2_k127_3183046_1 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 4.168e-275 859.0
HKD2_k127_3183046_10 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 422.0
HKD2_k127_3183046_11 transporter, permease K02033,K15581 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 415.0
HKD2_k127_3183046_12 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001417 406.0
HKD2_k127_3183046_13 Binding-protein-dependent transport system inner membrane component K02034,K15582 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003442 388.0
HKD2_k127_3183046_14 TAP-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 366.0
HKD2_k127_3183046_15 COG1192 ATPases involved in chromosome partitioning K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 352.0
HKD2_k127_3183046_16 signal transduction histidine kinase K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 336.0
HKD2_k127_3183046_17 ParB-like nuclease domain K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 318.0
HKD2_k127_3183046_18 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006221 301.0
HKD2_k127_3183046_19 SPFH domain / Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002681 281.0
HKD2_k127_3183046_2 highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues K01915 - 6.3.1.2 1.047e-238 745.0
HKD2_k127_3183046_20 Oxidoreductase family, NAD-binding Rossmann fold K09949 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003204 291.0
HKD2_k127_3183046_21 ABC transporter K09697 - 3.6.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000004632 267.0
HKD2_k127_3183046_22 COG1668 ABC-type Na efflux pump, permease component K09696 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008453 264.0
HKD2_k127_3183046_23 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0018130,GO:0019438,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000006349 240.0
HKD2_k127_3183046_24 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000001335 235.0
HKD2_k127_3183046_25 D,D-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.0000000000000000000000000000000000000000000000000000005665 199.0
HKD2_k127_3183046_26 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000001621 169.0
HKD2_k127_3183046_27 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000000002523 160.0
HKD2_k127_3183046_28 cytochrome - - - 0.00000000000000000000000000000000000000007986 159.0
HKD2_k127_3183046_29 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000001153 155.0
HKD2_k127_3183046_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 7.52e-218 681.0
HKD2_k127_3183046_30 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000000000002379 147.0
HKD2_k127_3183046_31 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000001173 113.0
HKD2_k127_3183046_32 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000000000000006171 98.0
HKD2_k127_3183046_33 Putative diguanylate phosphodiesterase - - - 0.0000000000000000004015 95.0
HKD2_k127_3183046_34 Belongs to the bacterial ribosomal protein bL34 family K02914 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000002777 80.0
HKD2_k127_3183046_35 Domain of unknown function (DUF4124) - - - 0.000000000000000746 85.0
HKD2_k127_3183046_36 atp synthase K02116 GO:0003674,GO:0003824,GO:0005215,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000001414 68.0
HKD2_k127_3183046_4 Belongs to the class-II aminoacyl-tRNA synthetase family K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 2.404e-205 653.0
HKD2_k127_3183046_5 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 610.0
HKD2_k127_3183046_6 Belongs to the ABC transporter superfamily K02031,K02032 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007805 616.0
HKD2_k127_3183046_7 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006494 593.0
HKD2_k127_3183046_8 response regulator K07712 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000848 559.0
HKD2_k127_3183046_9 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 450.0
HKD2_k127_319088_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 1.556e-243 756.0
HKD2_k127_319088_1 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 2.476e-229 746.0
HKD2_k127_319088_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 2.663e-199 628.0
HKD2_k127_319088_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002674 471.0
HKD2_k127_319088_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000002137 258.0
HKD2_k127_319088_5 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000007199 236.0
HKD2_k127_319088_6 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000004661 225.0
HKD2_k127_319088_7 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000005672 207.0
HKD2_k127_319088_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000000002616 147.0
HKD2_k127_320270_0 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000602 507.0
HKD2_k127_320270_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007918 462.0
HKD2_k127_320270_10 catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000001014 246.0
HKD2_k127_320270_11 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000000000000000000002182 236.0
HKD2_k127_320270_12 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000002008 249.0
HKD2_k127_320270_13 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.0000000000000000000000000000000000000000000000000000000000004103 218.0
HKD2_k127_320270_14 Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle K08316 - 2.1.1.171 0.000000000000000000000000000000000000001015 154.0
HKD2_k127_320270_15 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000002465 123.0
HKD2_k127_320270_16 Domain of unknown function (DUF4124) - - - 0.0000000000000000000004723 104.0
HKD2_k127_320270_17 there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc K02913 - - 0.0000000000000000002851 87.0
HKD2_k127_320270_18 RNA polymerase sigma K03089 - - 0.0002045 45.0
HKD2_k127_320270_2 Acetyl-coenzyme A transporter 1 K08218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 456.0
HKD2_k127_320270_3 PFAM Fatty acid desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 396.0
HKD2_k127_320270_4 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 328.0
HKD2_k127_320270_5 Exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 321.0
HKD2_k127_320270_6 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019897,GO:0019898,GO:0031224,GO:0031226,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 321.0
HKD2_k127_320270_7 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001498 276.0
HKD2_k127_320270_8 TIGRFAM Cell division ATP-binding protein FtsE K09812 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002269 287.0
HKD2_k127_320270_9 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001362 259.0
HKD2_k127_3213232_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 2.108e-227 734.0
HKD2_k127_3213232_1 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 401.0
HKD2_k127_3213232_2 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003652 363.0
HKD2_k127_3213232_3 Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position K11211 - 2.7.1.166 0.000000000000000000000000000000000000000000000000001886 192.0
HKD2_k127_3213232_4 Large-conductance mechanosensitive channel, MscL K03282 - - 0.0000000000000000000000000000000000000000446 154.0
HKD2_k127_3213232_5 protein conserved in bacteria - - - 0.00000000000000000006695 91.0
HKD2_k127_322726_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01576,K01652 - 2.2.1.6,4.1.1.7 2.369e-268 841.0
HKD2_k127_322726_1 DNA topological change K03168 - 5.99.1.2 8.886e-236 754.0
HKD2_k127_322726_10 PFAM Glucose Sorbosone dehydrogenase K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003145 360.0
HKD2_k127_322726_11 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 334.0
HKD2_k127_322726_12 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000265 325.0
HKD2_k127_322726_13 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 319.0
HKD2_k127_322726_14 bacteriocin export ABC transporter, lactococcin 972 group K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 292.0
HKD2_k127_322726_15 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000722 295.0
HKD2_k127_322726_16 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001794 276.0
HKD2_k127_322726_17 Bacterial regulatory helix-turn-helix protein, lysR family K03566 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001029 252.0
HKD2_k127_322726_18 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000001588 234.0
HKD2_k127_322726_19 Uracil DNA glycosylase superfamily - - - 0.00000000000000000000000000000000000000000000000000001616 197.0
HKD2_k127_322726_2 PQQ-like domain K00117 - 1.1.5.2 1.887e-210 673.0
HKD2_k127_322726_20 PPIC-type PPIASE domain - - - 0.0000000000000000000000000000000000000000000001731 179.0
HKD2_k127_322726_21 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.00000000000000000000000000000000000000000001438 168.0
HKD2_k127_322726_22 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000004696 161.0
HKD2_k127_322726_23 methyltransferase - - - 0.0000000000000000000000000000000000000004117 155.0
HKD2_k127_322726_24 GntR family transcriptional regulator K07979 - - 0.00000000000000000000000000001235 123.0
HKD2_k127_322726_25 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000000006425 126.0
HKD2_k127_322726_26 Bacterial extracellular solute-binding protein K02020,K22003 - 5.3.3.7 0.00000000000000007635 92.0
HKD2_k127_322726_27 Bacterial virulence protein (VirJ) - - - 0.000003124 58.0
HKD2_k127_322726_3 Multicopper oxidase K04753 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 506.0
HKD2_k127_322726_4 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 528.0
HKD2_k127_322726_5 Amino acid permease K11735 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 496.0
HKD2_k127_322726_6 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 456.0
HKD2_k127_322726_7 Cobalamin-independent synthase, Catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 440.0
HKD2_k127_322726_8 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007485 414.0
HKD2_k127_322726_9 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 404.0
HKD2_k127_3228942_0 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 1.018e-263 827.0
HKD2_k127_3228942_1 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 398.0
HKD2_k127_3228942_2 Belongs to the ParA family K04562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009595 310.0
HKD2_k127_3228942_3 PFAM GTP-binding signal recognition particle SRP54 G- domain K02404 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007851 293.0
HKD2_k127_3228942_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003867 272.0
HKD2_k127_3228942_5 Protein of unknown function (DUF2802) - - - 0.0001312 50.0
HKD2_k127_3232098_0 TIGRFAM ATP-dependent helicase HrpA K03578 - 3.6.4.13 4.379e-306 1007.0
HKD2_k127_3232098_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 1.348e-218 697.0
HKD2_k127_3232098_10 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000000000000000000000007233 203.0
HKD2_k127_3232098_11 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 0.0000000000000000000000000000000000000000000000000000000271 201.0
HKD2_k127_3232098_12 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.00000000000000000000000000000000000000000004059 165.0
HKD2_k127_3232098_13 PFAM NUDIX hydrolase - - - 0.0000000000000000000000000000000000000001648 160.0
HKD2_k127_3232098_14 Outer membrane lipoprotein - - - 0.000000000000000000001253 103.0
HKD2_k127_3232098_15 protein acetylation - - - 0.000000000000009863 81.0
HKD2_k127_3232098_16 Peptidase propeptide and YPEB domain - - - 0.00008969 51.0
HKD2_k127_3232098_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 2.162e-204 645.0
HKD2_k127_3232098_3 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 589.0
HKD2_k127_3232098_4 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 567.0
HKD2_k127_3232098_5 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004673 401.0
HKD2_k127_3232098_6 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07660 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 321.0
HKD2_k127_3232098_7 signal transduction histidine kinase K07637 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 326.0
HKD2_k127_3232098_8 MazG nucleotide pyrophosphohydrolase domain K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 286.0
HKD2_k127_3232098_9 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000001004 271.0
HKD2_k127_33082_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788 - - 0.0 1366.0
HKD2_k127_33082_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07789 - - 0.0 1356.0
HKD2_k127_33082_10 Belongs to the pseudouridine synthase RsuA family K06181 - 5.4.99.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002126 271.0
HKD2_k127_33082_11 Asp Glu hydantoin racemase K01799,K06033 - 4.1.1.76,5.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000004642 244.0
HKD2_k127_33082_12 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000001593 207.0
HKD2_k127_33082_13 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000461 214.0
HKD2_k127_33082_14 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000001078 188.0
HKD2_k127_33082_15 PFAM Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000008405 194.0
HKD2_k127_33082_16 DoxX K15977 - - 0.0000000000000000000000000000000000000000000000001192 192.0
HKD2_k127_33082_17 - - - - 0.000000000000000000000000000000000000000000000007179 192.0
HKD2_k127_33082_18 Putative DNA-binding domain - - - 0.00000000000000000000000000000000000000000000001035 181.0
HKD2_k127_33082_19 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000000000000000000006408 176.0
HKD2_k127_33082_2 Elongator protein 3, MiaB family, Radical SAM - - - 1.16e-247 781.0
HKD2_k127_33082_20 SMP-30/Gluconolaconase/LRE-like region - - - 0.0000000000000000000000000000000000453 147.0
HKD2_k127_33082_21 metal-dependent hydrolase with the TIM-barrel fold K07048 - - 0.0000000000000000000000000000000004825 147.0
HKD2_k127_33082_22 Predicted integral membrane protein (DUF2282) - - - 0.00000000000000000000000000000005129 132.0
HKD2_k127_33082_23 PepSY-associated TM region - - - 0.00000000000000000000000000005716 130.0
HKD2_k127_33082_24 Protein of unknown function (DUF3592) - - - 0.00000000000000000000000002783 128.0
HKD2_k127_33082_25 COG0188 Type IIA topoisomerase (DNA gyrase topo II, topoisomerase IV), A subunit - - - 0.00000000000000127 80.0
HKD2_k127_33082_26 OmpA-like transmembrane domain K03286 - - 0.000005329 52.0
HKD2_k127_33082_27 Protein of unknown function (DUF1109) - - - 0.000024 55.0
HKD2_k127_33082_28 Metallo-beta-lactamase superfamily - - - 0.0002234 53.0
HKD2_k127_33082_3 Protein of unknown function (DUF1800) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006847 545.0
HKD2_k127_33082_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 489.0
HKD2_k127_33082_5 Protein of unknown function (DUF1501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 466.0
HKD2_k127_33082_6 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 431.0
HKD2_k127_33082_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009263 397.0
HKD2_k127_33082_8 Belongs to the GST superfamily K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005694 349.0
HKD2_k127_33082_9 Belongs to the UPF0276 family K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 343.0
HKD2_k127_33420_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.998e-233 731.0
HKD2_k127_33420_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 3.334e-228 717.0
HKD2_k127_33420_2 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007983 414.0
HKD2_k127_33420_3 Peptidase family M48 - - - 0.000004131 53.0
HKD2_k127_3484799_0 TIGRFAM type IV-A pilus assembly ATPase PilB K02652 - - 1.821e-228 717.0
HKD2_k127_3484799_1 Type II secretion system K02653 - - 0.00000000000000000000000000000832 122.0
HKD2_k127_3589587_0 glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1472.0
HKD2_k127_3667266_0 PFAM TrkA-N domain K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001861 593.0
HKD2_k127_3667266_1 DNA helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 483.0
HKD2_k127_3667266_2 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 360.0
HKD2_k127_3667266_3 Belongs to the GST superfamily K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000008674 247.0
HKD2_k127_3667266_4 Prokaryotic Cytochrome C oxidase subunit IV - - - 0.00000000000000000000000000000004645 128.0
HKD2_k127_3667266_5 COG0457 FOG TPR repeat - - - 0.0000000000000000148 96.0
HKD2_k127_3667266_6 - - - - 0.000000000001281 81.0
HKD2_k127_3667266_7 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000005166 48.0
HKD2_k127_3667266_8 - - - - 0.0001433 55.0
HKD2_k127_3834736_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003313 565.0
HKD2_k127_3834736_1 MmgE/PrpD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 539.0
HKD2_k127_3834736_10 decarboxylase K01607 - 4.1.1.44 0.00000000005752 71.0
HKD2_k127_3834736_2 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001836 464.0
HKD2_k127_3834736_3 Glycosyltransferase family 9 (heptosyltransferase) K02849 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 393.0
HKD2_k127_3834736_4 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000389 376.0
HKD2_k127_3834736_5 PFAM ABC transporter related K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007289 347.0
HKD2_k127_3834736_6 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 332.0
HKD2_k127_3834736_7 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001043 281.0
HKD2_k127_3834736_8 decarboxylase K01607 - 4.1.1.44 0.00000000000000000000000002084 123.0
HKD2_k127_3834736_9 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - 0.000000000000000000000007341 103.0
HKD2_k127_3837035_0 secondary active sulfate transmembrane transporter activity K03321 - - 6.92e-271 844.0
HKD2_k127_3837035_1 Sodium/hydrogen exchanger family K03316 - - 4.885e-201 641.0
HKD2_k127_3837035_10 PFAM OmpA domain protein transmembrane region-containing protein K03286 - - 0.0000007086 58.0
HKD2_k127_3837035_2 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 451.0
HKD2_k127_3837035_3 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002412 455.0
HKD2_k127_3837035_4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000003415 258.0
HKD2_k127_3837035_5 Domain of unknown function (DUF4118) - - - 0.0000000000000000000000000000000000000000000003673 192.0
HKD2_k127_3837035_6 bacterial OsmY and nodulation domain K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.00000000000000000000000000000000000007325 149.0
HKD2_k127_3837035_7 CsbD-like - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000003097 100.0
HKD2_k127_3837035_8 Transcriptional regulatory protein, C terminal - - - 0.00000000000000001225 87.0
HKD2_k127_3837035_9 UPF0391 membrane protein - - - 0.000000000000001725 78.0
HKD2_k127_3837291_0 Isocitrate dehydrogenase K00031 - 1.1.1.42 0.0 1067.0
HKD2_k127_3837291_1 Aminomethyltransferase folate-binding domain K15066 - 2.1.1.341 2.087e-235 735.0
HKD2_k127_3837291_2 PFAM glycine cleavage T protein (aminomethyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003959 589.0
HKD2_k127_3837291_3 Fructose-bisphosphate aldolase class-I K01623 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 397.0
HKD2_k127_3837291_4 PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 390.0
HKD2_k127_3837291_5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000005404 107.0
HKD2_k127_3873781_0 SMART Elongator protein 3 MiaB NifB - - - 9.294e-227 713.0
HKD2_k127_3873781_1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 3.158e-224 718.0
HKD2_k127_3873781_10 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002224 265.0
HKD2_k127_3873781_11 peptidylprolyl isomerase, FKBP-type K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000004897 250.0
HKD2_k127_3873781_12 Protein of unknown function (DUF3014) - - - 0.000000000000000000000000000000000000000000000000001031 193.0
HKD2_k127_3873781_14 Glycine-zipper domain - - - 0.000000000002097 76.0
HKD2_k127_3873781_15 Sh3 type 3 domain protein K01361 - 3.4.21.96 0.00000000001041 71.0
HKD2_k127_3873781_16 Putative auto-transporter adhesin, head GIN domain - - - 0.0000000006958 70.0
HKD2_k127_3873781_17 - - - - 0.00000007717 57.0
HKD2_k127_3873781_2 MacB-like periplasmic core domain - - - 3.632e-213 688.0
HKD2_k127_3873781_3 alginic acid biosynthetic process K01729 - 4.2.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002729 555.0
HKD2_k127_3873781_4 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 542.0
HKD2_k127_3873781_5 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 500.0
HKD2_k127_3873781_6 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005491 376.0
HKD2_k127_3873781_7 Protein of unknown function (DUF1501) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 359.0
HKD2_k127_3873781_8 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001771 341.0
HKD2_k127_3873781_9 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001438 286.0
HKD2_k127_3875125_0 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004243 587.0
HKD2_k127_3875125_1 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 308.0
HKD2_k127_3875125_2 - - - - 0.0000000000000000001004 103.0
HKD2_k127_3875125_3 Putative 2OG-Fe(II) oxygenase - - - 0.00000000000001588 81.0
HKD2_k127_3875125_5 SCP-2 sterol transfer family - - - 0.00000000000004438 81.0
HKD2_k127_3875125_6 - - - - 0.000000003175 61.0
HKD2_k127_3875125_7 Haloacid dehalogenase-like hydrolase - - - 0.00000007026 65.0
HKD2_k127_3875777_0 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 360.0
HKD2_k127_3875777_1 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001601 269.0
HKD2_k127_3875777_2 - - - - 0.00000000000000000000000001353 113.0
HKD2_k127_3875777_3 endoribonuclease L-PSP - - - 0.00000000000000000001885 97.0
HKD2_k127_3889460_0 serine dehydratase beta chain K01752 - 4.3.1.17 1.12e-243 762.0
HKD2_k127_3889460_1 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 545.0
HKD2_k127_3889460_2 Phosphate acetyl/butaryl transferase K00625 - 2.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007883 437.0
HKD2_k127_3889460_3 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009345 433.0
HKD2_k127_3889460_4 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007069 400.0
HKD2_k127_3889460_5 Asparaginase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 402.0
HKD2_k127_3889460_6 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004637 378.0
HKD2_k127_3889460_7 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002253 251.0
HKD2_k127_3889460_8 endonuclease activity - - - 0.0000000000000000000000000000002768 131.0
HKD2_k127_3889460_9 Evidence 5 No homology to any previously reported sequences - - - 0.00000000001731 72.0
HKD2_k127_3911375_0 Beta-Casp domain K07576 - - 3.025e-200 632.0
HKD2_k127_3911375_1 L-2-hydroxyglutarate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005079 402.0
HKD2_k127_3911375_10 - - - - 0.0000000000000000000000000000005868 126.0
HKD2_k127_3911375_12 Beta-lactamase - - - 0.00000004323 62.0
HKD2_k127_3911375_2 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005535 354.0
HKD2_k127_3911375_3 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 301.0
HKD2_k127_3911375_4 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006748 282.0
HKD2_k127_3911375_5 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000000000000000000000000000000002027 205.0
HKD2_k127_3911375_6 Domain of Unknown Function (DUF1080) - - - 0.00000000000000000000000000000000000000000000000000008 194.0
HKD2_k127_3911375_7 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0003674,GO:0003824,GO:0004735,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.0000000000000000000000000000000000000000702 160.0
HKD2_k127_3911375_8 Methyltransferase domain - - - 0.000000000000000000000000000000000000001113 162.0
HKD2_k127_3911375_9 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.000000000000000000000000000000000000004636 149.0
HKD2_k127_3954607_0 PFAM response regulator receiver K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005441 541.0
HKD2_k127_3954607_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002488 498.0
HKD2_k127_3954607_2 Histidine kinase K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 388.0
HKD2_k127_3954607_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005319 376.0
HKD2_k127_3954607_4 Belongs to the N-Me-Phe pilin family K02650 - - 0.0000000000000000002121 90.0
HKD2_k127_3963392_0 Belongs to the Orn Lys Arg decarboxylase class-II family K00928,K12526 - 2.7.2.4,4.1.1.20 3.603e-297 935.0
HKD2_k127_3963392_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.105e-254 796.0
HKD2_k127_3963392_10 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000007939 242.0
HKD2_k127_3963392_11 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000005829 238.0
HKD2_k127_3963392_12 MerR family regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000001162 205.0
HKD2_k127_3963392_13 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000002301 160.0
HKD2_k127_3963392_14 - - - - 0.000000000000000000000000000000000000000006704 158.0
HKD2_k127_3963392_15 COG4635 Flavodoxin K00230 - 1.3.5.3 0.0000000000000000000000000000000000000005624 156.0
HKD2_k127_3963392_16 - - - - 0.0000000000000000000000000000000005294 148.0
HKD2_k127_3963392_17 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000006875 123.0
HKD2_k127_3963392_18 protein, YerC YecD - - - 0.00000000000000000000000001052 112.0
HKD2_k127_3963392_19 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 0.00000000000000000000005354 102.0
HKD2_k127_3963392_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 496.0
HKD2_k127_3963392_20 Type II secretory pathway component ExeA K02450,K12283 - - 0.000000000000000002 98.0
HKD2_k127_3963392_21 Major facilitator Superfamily - - - 0.00004754 45.0
HKD2_k127_3963392_22 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0001088 51.0
HKD2_k127_3963392_3 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 431.0
HKD2_k127_3963392_4 Histidine biosynthesis bifunctional protein HisB K01089 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 411.0
HKD2_k127_3963392_5 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 375.0
HKD2_k127_3963392_6 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005701 342.0
HKD2_k127_3963392_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 330.0
HKD2_k127_3963392_8 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 324.0
HKD2_k127_3963392_9 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007003 317.0
HKD2_k127_3980522_0 Protein of unknown function (DUF1593) - - - 2.831e-201 640.0
HKD2_k127_3980522_1 Carboxylesterase family K03929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 521.0
HKD2_k127_3980522_11 Zn-dependent - - - 0.0000000000000000000000000000000003599 143.0
HKD2_k127_3980522_12 ASCH - - - 0.00000000000000000000000000000003739 130.0
HKD2_k127_3980522_13 amidohydrolase - - - 0.000000000000000000000000000008253 134.0
HKD2_k127_3980522_14 Esterase PHB depolymerase K03932 - - 0.000000000000000000000000000186 119.0
HKD2_k127_3980522_15 Protein involved in outer membrane biogenesis - - - 0.00000000000000000000000001986 118.0
HKD2_k127_3980522_16 PFAM glycosyl transferase group 1 K00696 - 2.4.1.14 0.00000000000000000000000002128 123.0
HKD2_k127_3980522_17 - - - - 0.0000000000000000000000002713 116.0
HKD2_k127_3980522_18 Methyltransferase FkbM domain - - - 0.00000000000000000000001696 107.0
HKD2_k127_3980522_19 - - - - 0.00000000000000000004058 104.0
HKD2_k127_3980522_2 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 511.0
HKD2_k127_3980522_20 - - - - 0.000000000000006312 87.0
HKD2_k127_3980522_21 Sulfotransferase family - - - 0.00000000001549 75.0
HKD2_k127_3980522_3 PFAM NADH flavin oxidoreductase NADH oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 343.0
HKD2_k127_3980522_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005283 295.0
HKD2_k127_3980522_5 COG0577 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001241 280.0
HKD2_k127_3980522_6 response to abiotic stimulus K06867 - - 0.000000000000000000000000000000000000000000000000000001893 212.0
HKD2_k127_3980522_7 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000003935 185.0
HKD2_k127_3980522_8 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000000000002511 185.0
HKD2_k127_3980522_9 SnoaL-like domain - - - 0.000000000000000000000000000000000002377 150.0
HKD2_k127_3997683_0 DNA polymerase type-B family K02336 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002585 619.0
HKD2_k127_3997683_1 Major Facilitator Superfamily K02429 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002039 531.0
HKD2_k127_3997683_10 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567,K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000001572 167.0
HKD2_k127_3997683_11 NHL repeat - - - 0.000000000000000000000000000000000000000003961 171.0
HKD2_k127_3997683_12 - - - - 0.00000000000000000000000000000000000005406 147.0
HKD2_k127_3997683_14 - - - - 0.00000000000000000000000001832 121.0
HKD2_k127_3997683_15 SNARE associated Golgi protein - - - 0.00000000000000000000001608 116.0
HKD2_k127_3997683_16 AntiSigma factor - - - 0.00000000000000000000003694 114.0
HKD2_k127_3997683_17 EamA-like transporter family - - - 0.000000000005794 68.0
HKD2_k127_3997683_19 SnoaL-like domain - - - 0.000008527 55.0
HKD2_k127_3997683_2 DNA topological change - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002259 500.0
HKD2_k127_3997683_3 AlkA N-terminal domain K13529 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 466.0
HKD2_k127_3997683_4 Transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 332.0
HKD2_k127_3997683_5 Glutathione S-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003177 321.0
HKD2_k127_3997683_6 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 299.0
HKD2_k127_3997683_7 ABC-2 family transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000002357 215.0
HKD2_k127_3997683_8 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000004029 178.0
HKD2_k127_3997683_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000864 183.0
HKD2_k127_4025731_0 Dehydrogenase K00117 - 1.1.5.2 2.471e-275 865.0
HKD2_k127_4025731_1 Coenzyme F420-dependent N5N10-methylene tetrahydromethanopterin reductase and related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 592.0
HKD2_k127_4025731_10 NUDIX domain - - - 0.000000000000000000000000000000000000000000001676 175.0
HKD2_k127_4025731_11 surface antigen variable number repeat protein K07001 - - 0.00000000000000000000000000000000000000122 160.0
HKD2_k127_4025731_12 Alpha beta hydrolase fold-3 domain protein - - - 0.00000000000000000000000000001075 123.0
HKD2_k127_4025731_13 Protein of unknown function (DUF3237) - - - 0.00000000000000000000000000002171 126.0
HKD2_k127_4025731_14 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000008616 117.0
HKD2_k127_4025731_15 - - - - 0.00000000002909 78.0
HKD2_k127_4025731_16 - - - - 0.000001373 57.0
HKD2_k127_4025731_17 Glyoxalase-like domain - - - 0.0003742 52.0
HKD2_k127_4025731_2 I - Lipid transport and metabolism - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 487.0
HKD2_k127_4025731_3 protein-glutamate methylesterase K00575,K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 425.0
HKD2_k127_4025731_4 Carboxylesterase family K03929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 388.0
HKD2_k127_4025731_5 receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 382.0
HKD2_k127_4025731_6 NHL repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 336.0
HKD2_k127_4025731_7 ankyrin repeat K15503 - - 0.00000000000000000000000000000000000000000000000000000000000003477 235.0
HKD2_k127_4025731_8 PAS domain K13924 - 2.1.1.80,3.1.1.61 0.000000000000000000000000000000000000000000000000000001747 216.0
HKD2_k127_4025731_9 Histidine kinase K01120,K07315 - 3.1.3.3,3.1.4.17 0.00000000000000000000000000000000000000000000004083 190.0
HKD2_k127_4075245_0 Dehydrogenase E1 component K00164 GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 0.0 1110.0
HKD2_k127_4075245_1 Aminotransferase class-III K00823 - 2.6.1.19 5.737e-233 728.0
HKD2_k127_4075245_10 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000009216 207.0
HKD2_k127_4075245_11 Protein of unknown function (DUF3187) - - - 0.00000000000000000000000000000000000000000008275 173.0
HKD2_k127_4075245_12 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.0000000000000000000000000000000000000000003258 167.0
HKD2_k127_4075245_13 Biopolymer transport protein ExbD TolR K03560 - - 0.00000000000000000000000000000000000000004116 157.0
HKD2_k127_4075245_14 MltA-interacting protein MipA K07274 - - 0.0000000000000000000000000000000000008169 150.0
HKD2_k127_4075245_15 Domain of unknown function (DUF4397) - - - 0.00000000000000000000000000000000000868 153.0
HKD2_k127_4075245_16 Tol-Pal system-associated acyl-CoA thioesterase K07107 - - 0.000000000000000000000000000000004173 132.0
HKD2_k127_4075245_17 COG3474 Cytochrome c2 K08738 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0015979,GO:0016020,GO:0044237,GO:0044464,GO:0071944 - 0.000000000000000000000000001392 123.0
HKD2_k127_4075245_18 Multidrug Resistance protein K03297 - - 0.00000000000000000007599 94.0
HKD2_k127_4075245_19 Multidrug Resistance protein K12962 - - 0.0000000000000006815 87.0
HKD2_k127_4075245_2 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 552.0
HKD2_k127_4075245_20 - - - - 0.00000000001348 75.0
HKD2_k127_4075245_21 - - - - 0.00000009772 61.0
HKD2_k127_4075245_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001869 505.0
HKD2_k127_4075245_4 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007593 482.0
HKD2_k127_4075245_5 Peptidogalycan biosysnthesis/recognition - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008723 416.0
HKD2_k127_4075245_6 Belongs to the arginase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 346.0
HKD2_k127_4075245_7 Serine aminopeptidase, S33 K03928 - 3.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 317.0
HKD2_k127_4075245_8 PFAM MotA TolQ ExbB proton channel K03562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002345 246.0
HKD2_k127_4075245_9 Putative Phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000003359 211.0
HKD2_k127_4087388_0 Belongs to the peptidase S16 family - - - 5.275e-261 829.0
HKD2_k127_4087388_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 7.483e-244 774.0
HKD2_k127_4087388_10 universal stress protein K14055 - - 0.0000000000000000000000000821 118.0
HKD2_k127_4087388_11 PFAM UspA - - - 0.00000000002928 75.0
HKD2_k127_4087388_2 Carbohydrate phosphorylase K00688 - 2.4.1.1 2.374e-228 722.0
HKD2_k127_4087388_3 Nicotinate phosphoribosyltransferase (NAPRTase) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 515.0
HKD2_k127_4087388_4 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007852 436.0
HKD2_k127_4087388_5 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009789 253.0
HKD2_k127_4087388_6 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000009566 252.0
HKD2_k127_4087388_7 PFAM isochorismatase hydrolase K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000008585 249.0
HKD2_k127_4087388_8 Phosphoribosyl transferase domain K07100 - - 0.00000000000000000000000000000000000000000000000000000008453 217.0
HKD2_k127_4087388_9 Phosphate acyltransferases - - - 0.000000000000000000000000000000000006125 146.0
HKD2_k127_4088019_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1505.0
HKD2_k127_4088019_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1285.0
HKD2_k127_4088019_10 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007572 625.0
HKD2_k127_4088019_11 DNA topological change K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 603.0
HKD2_k127_4088019_12 PQQ-like domain K05889 - 1.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008484 579.0
HKD2_k127_4088019_13 Short chain fatty acid transporter K02106 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006135 522.0
HKD2_k127_4088019_14 FecR protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 535.0
HKD2_k127_4088019_15 Belongs to the citrate synthase family K01659 GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704 2.3.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004737 511.0
HKD2_k127_4088019_16 Carbohydrate-selective porin, OprB family K16079,K16080 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009305 510.0
HKD2_k127_4088019_17 FAD binding domain K00480 - 1.14.13.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 418.0
HKD2_k127_4088019_18 beta-keto acid cleavage enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009323 398.0
HKD2_k127_4088019_19 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001972 410.0
HKD2_k127_4088019_2 synthetase K01908 - 6.2.1.17 2.823e-275 859.0
HKD2_k127_4088019_20 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K03417 - 4.1.3.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 411.0
HKD2_k127_4088019_21 long-chain fatty acid transporting porin activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 387.0
HKD2_k127_4088019_22 Protein of unknown function (DUF1552) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 362.0
HKD2_k127_4088019_23 cytochrome K17230 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007485 354.0
HKD2_k127_4088019_24 COG3264 Small-conductance mechanosensitive channel K05802 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 340.0
HKD2_k127_4088019_25 protein histidine kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003593 334.0
HKD2_k127_4088019_26 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 331.0
HKD2_k127_4088019_27 Transcriptional regulatory protein, C terminal K07665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 309.0
HKD2_k127_4088019_28 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 307.0
HKD2_k127_4088019_29 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 291.0
HKD2_k127_4088019_3 PFAM glycoside hydrolase family 3 domain protein K05349 - 3.2.1.21 2.286e-268 847.0
HKD2_k127_4088019_30 outer membrane efflux protein K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 295.0
HKD2_k127_4088019_31 PFAM NADPH-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002202 262.0
HKD2_k127_4088019_32 PFAM Methyltransferase type 12 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001664 261.0
HKD2_k127_4088019_33 Alginate export - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003438 268.0
HKD2_k127_4088019_34 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000002164 250.0
HKD2_k127_4088019_35 ribonuclease inhibitor activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002064 251.0
HKD2_k127_4088019_36 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004218 254.0
HKD2_k127_4088019_37 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007272 245.0
HKD2_k127_4088019_38 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002449 245.0
HKD2_k127_4088019_39 aldo-keto reductase (NADP) activity K05275 - 1.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000002849 244.0
HKD2_k127_4088019_4 DNA helicase K03654 - 3.6.4.12 2.082e-247 780.0
HKD2_k127_4088019_40 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000005637 247.0
HKD2_k127_4088019_41 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components - - - 0.00000000000000000000000000000000000000000000000000000000000000000276 235.0
HKD2_k127_4088019_42 GDSL-like Lipase/Acylhydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000003145 241.0
HKD2_k127_4088019_43 Major Facilitator - - - 0.0000000000000000000000000000000000000000000000000000000000002192 233.0
HKD2_k127_4088019_44 protein conserved in bacteria K09966 - - 0.0000000000000000000000000000000000000000000000000000000001152 206.0
HKD2_k127_4088019_45 - - - - 0.0000000000000000000000000000000000000000000000000000000001831 213.0
HKD2_k127_4088019_46 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000003494 210.0
HKD2_k127_4088019_47 ABC transporter, periplasmic molybdate-binding protein K02020 GO:0003674,GO:0005488,GO:0030973,GO:0043167,GO:0043168 - 0.00000000000000000000000000000000000000000000000000000008726 204.0
HKD2_k127_4088019_48 protein possibly involved in utilization of glycolate and propanediol - - - 0.0000000000000000000000000000000000000000000000000000007271 198.0
HKD2_k127_4088019_49 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000002591 190.0
HKD2_k127_4088019_5 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA K12297 - 2.1.1.173,2.1.1.264 5.312e-245 782.0
HKD2_k127_4088019_50 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000001638 179.0
HKD2_k127_4088019_51 PFAM Cupin 2 conserved barrel domain protein - - - 0.0000000000000000000000000000000000000003205 155.0
HKD2_k127_4088019_52 - - - - 0.000000000000000000000000000000000000001093 161.0
HKD2_k127_4088019_53 transcriptional regulator - - - 0.0000000000000000000000000000000000003036 149.0
HKD2_k127_4088019_54 - - - - 0.00000000000000000000000000000000000032 155.0
HKD2_k127_4088019_55 - - - - 0.0000000000000000000000000000002639 139.0
HKD2_k127_4088019_56 Predicted membrane protein (DUF2306) - - - 0.0000000000000000000000000000008878 139.0
HKD2_k127_4088019_57 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000003154 126.0
HKD2_k127_4088019_58 MAPEG family - - - 0.0000000000000000000000000001111 123.0
HKD2_k127_4088019_59 - - - - 0.0000000000000000000000000005485 119.0
HKD2_k127_4088019_6 2-methylcitrate dehydratase K01720 - 4.2.1.79 5.258e-222 704.0
HKD2_k127_4088019_61 - - - - 0.000000000000000000000000001283 121.0
HKD2_k127_4088019_62 phospholipase Carboxylesterase - - - 0.00000000000000000000000001042 121.0
HKD2_k127_4088019_63 Ankyrin repeat and kinase domain containing 1 K16289 - 2.7.11.1 0.00000000000000000000000004144 124.0
HKD2_k127_4088019_64 acetyltransferase - - - 0.0000000000000000000000002851 114.0
HKD2_k127_4088019_65 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000007766 107.0
HKD2_k127_4088019_68 - - - - 0.00000000000000000002632 98.0
HKD2_k127_4088019_69 general secretion pathway protein K02450 - - 0.00000000000000000006652 105.0
HKD2_k127_4088019_7 DNA topological change K03168 - 5.99.1.2 4.995e-213 689.0
HKD2_k127_4088019_70 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000009368 86.0
HKD2_k127_4088019_71 - - - - 0.0000000000000001264 91.0
HKD2_k127_4088019_72 - - - - 0.0000000000000006703 89.0
HKD2_k127_4088019_73 - - - - 0.000000000000001174 88.0
HKD2_k127_4088019_74 - - - - 0.000000000000001929 90.0
HKD2_k127_4088019_75 transposition K07483,K07497 - - 0.000000000000008076 77.0
HKD2_k127_4088019_76 - - - - 0.000000000001245 73.0
HKD2_k127_4088019_77 - - - - 0.00000000007052 70.0
HKD2_k127_4088019_79 - - - - 0.000000009597 63.0
HKD2_k127_4088019_8 Dehydrogenase K00117 - 1.1.5.2 8.248e-210 676.0
HKD2_k127_4088019_81 SnoaL-like domain - - - 0.000001359 61.0
HKD2_k127_4088019_83 - - - - 0.0001415 48.0
HKD2_k127_4088019_84 Type III secretion system lipoprotein chaperone (YscW) K09914 - - 0.0002575 49.0
HKD2_k127_4088019_85 Metallo-beta-lactamase superfamily - - - 0.0004289 53.0
HKD2_k127_4088019_9 Belongs to the peptidase S1B family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 628.0
HKD2_k127_4097000_0 secondary active sulfate transmembrane transporter activity K03321 - - 1.333e-280 872.0
HKD2_k127_4233424_0 Major Facilitator Superfamily - - - 3.012e-205 657.0
HKD2_k127_4233424_1 Dehydrogenase K00114 - 1.1.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002321 611.0
HKD2_k127_4233424_10 Prokaryotic cytochrome b561 K12262 - - 0.000000000000000000000000000000000000000001234 163.0
HKD2_k127_4233424_11 - - - - 0.00000000000000000000000000000000000001447 161.0
HKD2_k127_4233424_12 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01576,K01652 - 2.2.1.6,4.1.1.7 0.00000000000000000000000000000000000018 143.0
HKD2_k127_4233424_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000001856 147.0
HKD2_k127_4233424_14 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000001616 122.0
HKD2_k127_4233424_15 Cytochrome c K17760 - 1.1.9.1 0.0000000000005094 74.0
HKD2_k127_4233424_16 Domain of unknown function (DUF4279) - - - 0.00000806 57.0
HKD2_k127_4233424_2 glucose sorbosone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 404.0
HKD2_k127_4233424_3 Biotin-lipoyl like K03543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 318.0
HKD2_k127_4233424_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001837 282.0
HKD2_k127_4233424_5 Protein of unknown function (DUF938) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006398 252.0
HKD2_k127_4233424_6 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000001872 241.0
HKD2_k127_4233424_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000006884 236.0
HKD2_k127_4233424_8 - - - - 0.000000000000000000000000000000000000000000000000000000007073 206.0
HKD2_k127_4233424_9 - - - - 0.000000000000000000000000000000000000000000000000000000191 211.0
HKD2_k127_4246349_0 Alpha-amylase domain K01187 - 3.2.1.20 0.0 1347.0
HKD2_k127_4246349_1 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 1.5e-323 1002.0
HKD2_k127_4246349_10 Redoxin - - - 0.00000000000000000000000000000000000000000000000000000000006818 210.0
HKD2_k127_4246349_11 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000035 195.0
HKD2_k127_4246349_12 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases K03825 GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031248,GO:0031365,GO:0032991,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564,GO:1902493,GO:1902494,GO:1990234 - 0.000000000000000000000000000000000000000000000005968 179.0
HKD2_k127_4246349_13 chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.0000000000000000000000000000000000000000001102 163.0
HKD2_k127_4246349_14 TonB dependent receptor - - - 0.00000000000000000000000000000000000000005305 173.0
HKD2_k127_4246349_15 - - - - 0.000000000000000000000000000004923 127.0
HKD2_k127_4246349_16 Anp1 - - - 0.00000000000000000000000001893 123.0
HKD2_k127_4246349_17 - - - - 0.0000000000000000000000001209 113.0
HKD2_k127_4246349_18 - - - - 0.00000000000000000000009799 110.0
HKD2_k127_4246349_19 - - - - 0.000000000000000000002527 103.0
HKD2_k127_4246349_2 Alpha amylase, catalytic domain - - - 2.026e-248 782.0
HKD2_k127_4246349_20 - - - - 0.0000000000000000007561 89.0
HKD2_k127_4246349_21 - - - - 0.0000000000000003216 85.0
HKD2_k127_4246349_23 - - - - 0.0003132 49.0
HKD2_k127_4246349_24 CAAX protease self-immunity - - - 0.0008049 50.0
HKD2_k127_4246349_3 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 9.468e-246 772.0
HKD2_k127_4246349_4 TonB dependent receptor - - - 1.339e-223 715.0
HKD2_k127_4246349_5 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 618.0
HKD2_k127_4246349_6 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 569.0
HKD2_k127_4246349_7 Uncharacterised MFS-type transporter YbfB K05548,K05819,K08195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007188 463.0
HKD2_k127_4246349_8 MatE K03327 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003637 379.0
HKD2_k127_4246349_9 Glucose / Sorbosone dehydrogenase K21430 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 319.0
HKD2_k127_4284046_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009221 601.0
HKD2_k127_4284046_1 ribosomal rna small subunit methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 547.0
HKD2_k127_4284046_2 PFAM pfkB family carbohydrate kinase K00856 - 2.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000926 460.0
HKD2_k127_4284046_3 COG0685 5,10-methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000005356 226.0
HKD2_k127_4284046_4 Bile acid K03453 - - 0.000000000000000000000000000000000000000000000000003981 193.0
HKD2_k127_4284046_5 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000007099 109.0
HKD2_k127_4286020_0 Acetoacetyl-CoA synthase K01907 - 6.2.1.16 5.923e-255 805.0
HKD2_k127_4286020_1 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 2.672e-210 669.0
HKD2_k127_4286020_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000001887 136.0
HKD2_k127_4286020_11 Preprotein translocase subunit YajC K03210 - - 0.000000000000000000000000000324 122.0
HKD2_k127_4286020_12 DoxX K15977 - - 0.00000000000000000000002494 109.0
HKD2_k127_4286020_13 PDZ domain - - - 0.0000000000000002471 91.0
HKD2_k127_4286020_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004983 592.0
HKD2_k127_4286020_3 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 510.0
HKD2_k127_4286020_4 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000877 424.0
HKD2_k127_4286020_5 essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation K04763 GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003692 390.0
HKD2_k127_4286020_6 Membrane protein TerC, possibly involved in tellurium resistance - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006274 302.0
HKD2_k127_4286020_7 carbonate dehydratase activity K01674 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003353 283.0
HKD2_k127_4286020_8 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000000000000000000000000000000001272 221.0
HKD2_k127_4286020_9 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000849 161.0
HKD2_k127_4388381_0 DNA topological change K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 359.0
HKD2_k127_4388381_1 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000001607 177.0
HKD2_k127_4397163_0 Peptidase M16 - - - 0.0 1041.0
HKD2_k127_4397163_1 PFAM PrkA AAA K07180 - - 2.543e-302 940.0
HKD2_k127_4397163_10 Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily K01919 - 6.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 485.0
HKD2_k127_4397163_11 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002045 459.0
HKD2_k127_4397163_12 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003879 461.0
HKD2_k127_4397163_13 Transcriptional regulator K06714,K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000496 445.0
HKD2_k127_4397163_14 Belongs to the UPF0229 family K09786 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 417.0
HKD2_k127_4397163_15 Reductase C-terminal K00529 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002863 418.0
HKD2_k127_4397163_16 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 407.0
HKD2_k127_4397163_17 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 394.0
HKD2_k127_4397163_18 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003865 393.0
HKD2_k127_4397163_19 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 391.0
HKD2_k127_4397163_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K15022 - 1.17.1.10 3.114e-281 875.0
HKD2_k127_4397163_20 (ABC) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 357.0
HKD2_k127_4397163_21 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 301.0
HKD2_k127_4397163_22 Diguanylate cyclase K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002349 280.0
HKD2_k127_4397163_23 Phospholipase/Carboxylesterase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000007892 249.0
HKD2_k127_4397163_24 Two component transcriptional regulator, winged helix family K07662,K19610 GO:0003674,GO:0003700,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010810,GO:0019219,GO:0019222,GO:0030155,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000001102 231.0
HKD2_k127_4397163_25 Histidine kinase K07640 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000003012 241.0
HKD2_k127_4397163_26 Belongs to the P(II) protein family K04751,K04752 - - 0.00000000000000000000000000000000000000000000000000003978 189.0
HKD2_k127_4397163_27 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.0000000000000000000000000000000000000000000000003381 185.0
HKD2_k127_4397163_28 - - - - 0.000000000000000000000000000000000000000000003438 171.0
HKD2_k127_4397163_29 proteolysis - - - 0.00000000000000000000000000000000000000000001359 173.0
HKD2_k127_4397163_3 pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 1.741e-265 829.0
HKD2_k127_4397163_30 - - - - 0.0000000000000000000000000000000004391 140.0
HKD2_k127_4397163_31 Domain of unknown function (DUF4340) - - - 0.00000000000000000000000000003198 134.0
HKD2_k127_4397163_32 Protein of unknown function (DUF3775) - - - 0.00000000000000000000000004503 111.0
HKD2_k127_4397163_33 - - - - 0.00000000000000001178 86.0
HKD2_k127_4397163_34 - - - - 0.000000000003386 74.0
HKD2_k127_4397163_35 - - - - 0.0000000006347 72.0
HKD2_k127_4397163_36 Protein of unknown function (DUF2845) - - - 0.000000009939 64.0
HKD2_k127_4397163_37 SH3 domain protein K07184 - - 0.000004233 58.0
HKD2_k127_4397163_38 - - - - 0.000132 48.0
HKD2_k127_4397163_4 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 1.409e-208 660.0
HKD2_k127_4397163_5 SpoVR like protein K06415 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004058 594.0
HKD2_k127_4397163_6 Helicase K03724 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009129 563.0
HKD2_k127_4397163_7 PFAM Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 550.0
HKD2_k127_4397163_8 dihydroorotase K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 525.0
HKD2_k127_4397163_9 ABC-type uncharacterized transport system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 520.0
HKD2_k127_442168_0 COG3666 Transposase and inactivated derivatives - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001614 432.0
HKD2_k127_442168_1 PFAM nitrogen-fixing NifU domain protein - - - 0.00000000002317 69.0
HKD2_k127_4523064_0 GAF domain - - - 1.458e-200 647.0
HKD2_k127_4523064_1 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004601 297.0
HKD2_k127_4523064_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.000000000000000000000000000000000000000000000000000000000654 210.0
HKD2_k127_4620655_0 COG4993 Glucose dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 565.0
HKD2_k127_4620655_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008977 465.0
HKD2_k127_4620655_10 CHRD domain containing protein - - - 0.00002906 54.0
HKD2_k127_4620655_2 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 441.0
HKD2_k127_4620655_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004781 351.0
HKD2_k127_4620655_4 TRAP transporter T-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000001569 240.0
HKD2_k127_4620655_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000006636 226.0
HKD2_k127_4620655_6 MerR, DNA binding K13639 - - 0.0000000000000000000000000000000000000000000000000000004662 211.0
HKD2_k127_4620655_7 PFAM TRAP dicarboxylate transporter- DctP subunit - - - 0.0000000000000000000000000000000000000000000000000002358 203.0
HKD2_k127_4620655_8 PQQ-like domain K00114 - 1.1.2.8 0.000000000000000000000000000000000000839 158.0
HKD2_k127_4620655_9 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000007254 68.0
HKD2_k127_4864154_0 glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 3.8e-203 639.0
HKD2_k127_4864154_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006228 356.0
HKD2_k127_4864154_2 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07663 GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002236 303.0
HKD2_k127_4864154_3 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001027 252.0
HKD2_k127_490832_0 response regulator receiver K02481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001481 591.0
HKD2_k127_490832_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006796 567.0
HKD2_k127_490832_2 With GlrK is part of a two-component signal transduction system regulating glmY K07715 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 457.0
HKD2_k127_490832_3 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 448.0
HKD2_k127_490832_4 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003495 318.0
HKD2_k127_490832_5 HDOD domain - - - 0.000000000000000000000000000000000000000005639 167.0
HKD2_k127_4917471_0 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009105 384.0
HKD2_k127_4917471_1 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 294.0
HKD2_k127_4917471_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001855 270.0
HKD2_k127_4933712_0 Belongs to the peptidase M16 family K07263 - - 1.881e-298 945.0
HKD2_k127_4933712_1 E1-E2 ATPase K01535 - 3.6.3.6 6.768e-291 914.0
HKD2_k127_4933712_10 - - - - 0.000004922 57.0
HKD2_k127_4933712_11 Enoyl-CoA hydratase/isomerase K18383 - 4.1.2.41,4.2.1.101 0.00007494 46.0
HKD2_k127_4933712_2 COG4993 Glucose dehydrogenase - - - 5.289e-217 693.0
HKD2_k127_4933712_3 PQQ enzyme repeat - - - 4.698e-207 661.0
HKD2_k127_4933712_4 MatE - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 525.0
HKD2_k127_4933712_5 Domain of unknown function (DUF4159) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006797 359.0
HKD2_k127_4933712_6 glutathione s-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004022 276.0
HKD2_k127_4933712_7 PRMT5 arginine-N-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000017 266.0
HKD2_k127_4933712_8 NHL repeat - - - 0.0000000000000000000000000000001538 137.0
HKD2_k127_4933712_9 Carboxylesterase family - - - 0.00000000004487 66.0
HKD2_k127_4988303_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 0.0 1050.0
HKD2_k127_4988303_1 Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003039 413.0
HKD2_k127_4988303_2 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 331.0
HKD2_k127_4988303_3 ABC-type molybdate transport system, permease component K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 302.0
HKD2_k127_4988303_4 GTP cyclohydrolase K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000009104 259.0
HKD2_k127_4988303_5 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001456 267.0
HKD2_k127_4988303_6 Amidohydrolase K10221 - 3.1.1.57 0.0000000000000000000000000000000000000000000218 162.0
HKD2_k127_4988303_7 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.000000000000000000000000000000000003912 145.0
HKD2_k127_4988303_8 Pilin (bacterial filament) K02650,K02655 - - 0.00000000000000000000000000000000003812 145.0
HKD2_k127_500522_0 DNA topological change K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002139 372.0
HKD2_k127_500522_1 Metallo-beta-lactamase superfamily - - - 0.00000006821 57.0
HKD2_k127_5123731_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 3.29e-318 1008.0
HKD2_k127_5123731_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 8.838e-229 721.0
HKD2_k127_5123731_10 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 323.0
HKD2_k127_5123731_11 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001569 287.0
HKD2_k127_5123731_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000553 274.0
HKD2_k127_5123731_13 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000002898 243.0
HKD2_k127_5123731_14 Transcriptional K03719 - - 0.00000000000000000000000000000000000000000000000000000000000001131 220.0
HKD2_k127_5123731_15 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000004424 204.0
HKD2_k127_5123731_16 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000008059 171.0
HKD2_k127_5123731_17 Protein of unknown function (DUF1697) - - - 0.000000000000000000000000000000000058 140.0
HKD2_k127_5123731_18 Domain of unknown function (DUF4389) - - - 0.000000000000000000000183 100.0
HKD2_k127_5123731_19 Helix-turn-helix XRE-family like proteins K07729 - - 0.0000000000000000000006731 102.0
HKD2_k127_5123731_2 Aminotransferase class I and II K00812 - 2.6.1.1 1.406e-212 670.0
HKD2_k127_5123731_20 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000003028 82.0
HKD2_k127_5123731_21 - - - - 0.000000000000004009 80.0
HKD2_k127_5123731_22 - - - - 0.000000005918 61.0
HKD2_k127_5123731_23 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000001374 62.0
HKD2_k127_5123731_24 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00000001414 68.0
HKD2_k127_5123731_3 Belongs to the amidase family K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 562.0
HKD2_k127_5123731_4 Lytic murein transglycosylase K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002662 549.0
HKD2_k127_5123731_5 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 495.0
HKD2_k127_5123731_6 glucose galactose transporter K02429 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 464.0
HKD2_k127_5123731_7 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 435.0
HKD2_k127_5123731_8 Major facilitator superfamily K08151 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004489 374.0
HKD2_k127_5123731_9 Uncharacterised MFS-type transporter YbfB - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000632 314.0
HKD2_k127_5124615_0 Sugar (and other) transporter - - - 1.361e-210 662.0
HKD2_k127_5124615_1 Transketolase, pyrimidine binding domain K21417 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005581 491.0
HKD2_k127_5124615_2 Sulfatase K01133 - 3.1.6.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007792 439.0
HKD2_k127_5124615_3 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 378.0
HKD2_k127_5124615_4 e3 binding domain K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004486 378.0
HKD2_k127_5124615_5 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000006646 196.0
HKD2_k127_5124615_6 LysE type translocator - GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0042968,GO:0042970,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000003646 164.0
HKD2_k127_5124615_7 Acetyltransferase (GNAT) domain K18816 - 2.3.1.82 0.0000000000000000000000000009092 123.0
HKD2_k127_5124615_8 Type III secretion system lipoprotein chaperone (YscW) - - - 0.000000000000000000000000006299 121.0
HKD2_k127_5124615_9 Putative inner membrane exporter, YdcZ K09936 - - 0.000000000000000000000001252 110.0
HKD2_k127_5152201_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1444.0
HKD2_k127_5152201_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 1.687e-264 828.0
HKD2_k127_5152201_10 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000004783 182.0
HKD2_k127_5152201_11 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000000004668 179.0
HKD2_k127_5152201_12 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - 0.0000000000000000000000000000000005809 132.0
HKD2_k127_5152201_13 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000000000000000003861 132.0
HKD2_k127_5152201_14 belongs to the Fur family K09826 - - 0.00000000000000000000000000000001342 134.0
HKD2_k127_5152201_15 Protein of unknown function (DUF1244) K09948 - - 0.00000000000000000000000000000001927 133.0
HKD2_k127_5152201_16 COG4968 Tfp pilus assembly protein PilE K02655 - - 0.000000000000000000001019 109.0
HKD2_k127_5152201_17 - - - - 0.00000000000000000004359 101.0
HKD2_k127_5152201_18 Type II transport protein GspH K08084 - - 0.0000000000000000002611 94.0
HKD2_k127_5152201_19 - - - - 0.000000000000000001724 99.0
HKD2_k127_5152201_2 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 585.0
HKD2_k127_5152201_20 Binds directly to 16S ribosomal RNA K02968 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000008009 87.0
HKD2_k127_5152201_21 COG4967 Tfp pilus assembly protein PilV - - - 0.000000000001333 80.0
HKD2_k127_5152201_22 Type IV Pilus-assembly protein W K02672 - - 0.00000000000437 79.0
HKD2_k127_5152201_23 Type II transport protein GspH K08084 - - 0.0000001055 62.0
HKD2_k127_5152201_24 Pilus assembly protein PilX K02673 - - 0.00007566 55.0
HKD2_k127_5152201_3 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006125 518.0
HKD2_k127_5152201_4 MatE - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006862,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015215,GO:0015230,GO:0015605,GO:0015711,GO:0015748,GO:0015833,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0034220,GO:0035350,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0044610,GO:0051179,GO:0051181,GO:0051182,GO:0051184,GO:0051185,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098656,GO:1901264,GO:1901505,GO:1901679,GO:1904680 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 507.0
HKD2_k127_5152201_5 MgsA AAA+ ATPase C terminal K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 501.0
HKD2_k127_5152201_6 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 434.0
HKD2_k127_5152201_7 Belongs to the FPP GGPP synthase family K02523 GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 389.0
HKD2_k127_5152201_8 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007873 348.0
HKD2_k127_5152201_9 Belongs to the ribF family K11753 GO:0003674,GO:0003824,GO:0003919,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008531,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0044237,GO:0070566 2.7.1.26,2.7.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000002093 274.0
HKD2_k127_5158313_0 PrpF protein K16514 - 5.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006609 481.0
HKD2_k127_5158313_1 belongs to the aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 491.0
HKD2_k127_5158313_2 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 468.0
HKD2_k127_5158313_3 Methionine synthase K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 439.0
HKD2_k127_5158313_4 Amidohydrolase K10221 - 3.1.1.57 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000246 317.0
HKD2_k127_5158313_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005564 269.0
HKD2_k127_5164578_0 cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 346.0
HKD2_k127_5164578_1 ATP-dependent helicase HrpB K03579 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000002705 269.0
HKD2_k127_5173046_0 Angiotensin-converting enzyme K01283 - 3.4.15.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 470.0
HKD2_k127_5173046_1 COG3104 Dipeptide tripeptide permease K03305 - - 0.0000000000000000000000000000000000000000009248 160.0
HKD2_k127_5187086_0 Cytochrome c K02198 - - 1.635e-226 720.0
HKD2_k127_5187086_1 Major facilitator superfamily K08223 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003789 516.0
HKD2_k127_5187086_10 Protein of unknown function (DUF3450) - - - 0.000000000000000000000000000000000000000000000000000000000000006389 226.0
HKD2_k127_5187086_11 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000005372 232.0
HKD2_k127_5187086_12 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - 0.000000000000000000000000000000000000000000000000000000002577 206.0
HKD2_k127_5187086_13 MotA/TolQ/ExbB proton channel family - - - 0.0000000000000000000000000000000000000000000000000004112 190.0
HKD2_k127_5187086_14 COG0526 Thiol-disulfide isomerase and thioredoxins K02199 - - 0.00000000000000000000000000000000000000000000000001169 187.0
HKD2_k127_5187086_15 Biopolymer transport protein ExbD/TolR - - - 0.00000000000000000000000000000000000000000000000002218 182.0
HKD2_k127_5187086_16 phosphate regulon transcriptional regulatory protein PhoB K07657 GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.00000000000000000000000000000000000000000001806 171.0
HKD2_k127_5187086_17 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000000000000000000000000000002961 165.0
HKD2_k127_5187086_18 Protein of unknown function (DUF3450) - - - 0.0000000000000000000000000000000000000000001363 169.0
HKD2_k127_5187086_19 - - - - 0.00000000000000000000000000000000000001788 148.0
HKD2_k127_5187086_2 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007407 407.0
HKD2_k127_5187086_20 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.000000000000000000000000000000000001213 147.0
HKD2_k127_5187086_21 Cytochrome C' - - - 0.00000000000000000000000000000000004989 141.0
HKD2_k127_5187086_22 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0000000000000000000000000000000002137 139.0
HKD2_k127_5187086_23 Cytochrome C biogenesis K02200 - - 0.0000000000000000000000000000000002905 145.0
HKD2_k127_5187086_24 Biopolymer transport protein ExbD/TolR K03559 - - 0.00000000000000000000000000000003153 130.0
HKD2_k127_5187086_25 subunit of a heme lyase K02200,K04017 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567 - 0.000000000000000000000000000001623 129.0
HKD2_k127_5187086_26 (twin-arginine translocation) pathway signal - - - 0.0000000000000000000000000004672 124.0
HKD2_k127_5187086_27 - - - - 0.0000000000000000000000001296 108.0
HKD2_k127_5187086_28 - - - - 0.000000000000000000000004053 112.0
HKD2_k127_5187086_29 PFAM Forkhead-associated protein - - - 0.000000003028 69.0
HKD2_k127_5187086_3 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004576 388.0
HKD2_k127_5187086_30 NAD ADP-ribosyltransferase activity. It is involved in the biological process described with protein ADP-ribosylation K10798 GO:0000002,GO:0000003,GO:0000122,GO:0000166,GO:0000228,GO:0000302,GO:0000303,GO:0000305,GO:0000715,GO:0000723,GO:0000724,GO:0000725,GO:0000785,GO:0000790,GO:0000791,GO:0000976,GO:0000977,GO:0000981,GO:0001012,GO:0001067,GO:0001228,GO:0001817,GO:0001818,GO:0002009,GO:0002064,GO:0002065,GO:0002066,GO:0002225,GO:0002376,GO:0002520,GO:0002521,GO:0002573,GO:0002682,GO:0002684,GO:0002697,GO:0002699,GO:0002700,GO:0002702,GO:0002759,GO:0002760,GO:0002784,GO:0002786,GO:0002791,GO:0002792,GO:0002803,GO:0002805,GO:0002807,GO:0002808,GO:0002831,GO:0002833,GO:0002920,GO:0002922,GO:0003002,GO:0003006,GO:0003254,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003690,GO:0003700,GO:0003824,GO:0003909,GO:0003910,GO:0003950,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005667,GO:0005694,GO:0005700,GO:0005703,GO:0005719,GO:0005730,GO:0005737,GO:0005739,GO:0006139,GO:0006140,GO:0006163,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006282,GO:0006284,GO:0006289,GO:0006293,GO:0006294,GO:0006296,GO:0006302,GO:0006310,GO:0006351,GO:0006355,GO:0006357,GO:0006366,GO:0006464,GO:0006471,GO:0006508,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006963,GO:0006974,GO:0006979,GO:0006996,GO:0006997,GO:0007000,GO:0007005,GO:0007154,GO:0007163,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0007179,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007389,GO:0007552,GO:0007610,GO:0008069,GO:0008104,GO:0008134,GO:0008150,GO:0008152,GO:0008219,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009303,GO:0009314,GO:0009408,GO:0009410,GO:0009411,GO:0009416,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009798,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009950,GO:0009953,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010043,GO:0010212,GO:0010243,GO:0010332,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010563,GO:0010604,GO:0010605,GO:0010611,GO:0010613,GO:0010628,GO:0010629,GO:0010639,GO:0010646,GO:0010647,GO:0010941,GO:0010942,GO:0010990,GO:0012501,GO:0012505,GO:0014070,GO:0014742,GO:0014743,GO:0015030,GO:0016043,GO:0016070,GO:0016072,GO:0016333,GO:0016334,GO:0016485,GO:0016540,GO:0016604,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016886,GO:0017144,GO:0018130,GO:0018193,GO:0018209,GO:0018312,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019899,GO:0019900,GO:0019901,GO:0019953,GO:0022412,GO:0022414,GO:0022607,GO:0022616,GO:0023019,GO:0023051,GO:0023052,GO:0023056,GO:0030097,GO:0030099,GO:0030154,GO:0030225,GO:0030331,GO:0030534,GO:0030575,GO:0030576,GO:0030707,GO:0030808,GO:0030809,GO:0030855,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031334,GO:0031347,GO:0031349,GO:0031960,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032042,GO:0032101,GO:0032103,GO:0032200,GO:0032204,GO:0032205,GO:0032501,GO:0032502,GO:0032504,GO:0032507,GO:0032660,GO:0032700,GO:0032774,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032880,GO:0032991,GO:0032993,GO:0033036,GO:0033043,GO:0033044,GO:0033143,GO:0033145,GO:0033146,GO:0033148,GO:0033365,GO:0033554,GO:0033683,GO:0033993,GO:0034248,GO:0034250,GO:0034504,GO:0034599,GO:0034605,GO:0034613,GO:0034614,GO:0034622,GO:0034641,GO:0034644,GO:0034645,GO:0034654,GO:0034660,GO:0035079,GO:0035080,GO:0035257,GO:0035258,GO:0035363,GO:0036094,GO:0036211,GO:0040008,GO:0040009,GO:0042220,GO:0042221,GO:0042391,GO:0042393,GO:0042493,GO:0042592,GO:0042769,GO:0042802,GO:0042826,GO:0042981,GO:0043067,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043254,GO:0043279,GO:0043388,GO:0043412,GO:0043434,GO:0043484,GO:0043502,GO:0043504,GO:0043523,GO:0043565,GO:0043900,GO:0043902,GO:0043933,GO:0044030,GO:0044057,GO:0044085,GO:0044087,GO:0044089,GO:0044093,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044454,GO:0044464,GO:0044703,GO:0045087,GO:0045185,GO:0045595,GO:0045597,GO:0045739,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045936,GO:0045944,GO:0045980,GO:0046034,GO:0046332,GO:0046483,GO:0047485,GO:0048037,GO:0048148,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048545,GO:0048583,GO:0048584,GO:0048609,GO:0048729,GO:0048731,GO:0048856,GO:0048869,GO:0048878,GO:0050662,GO:0050707,GO:0050708,GO:0050709,GO:0050710,GO:0050776,GO:0050778,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050801,GO:0050879,GO:0050881,GO:0050882,GO:0050896,GO:0051046,GO:0051048,GO:0051049,GO:0051051,GO:0051052,GO:0051053,GO:0051054,GO:0051094,GO:0051098,GO:0051099,GO:0051101,GO:0051103,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051223,GO:0051224,GO:0051235,GO:0051239,GO:0051240,GO:0051241,GO:0051252,GO:0051253,GO:0051254,GO:0051276,GO:0051287,GO:0051385,GO:0051427,GO:0051457,GO:0051604,GO:0051606,GO:0051641,GO:0051651,GO:0051704,GO:0051716,GO:0051881,GO:0051900,GO:0051901,GO:0055086,GO:0060249,GO:0060255,GO:0060341,GO:0060359,GO:0060390,GO:0060391,GO:0060429,GO:0062012,GO:0062014,GO:0065003,GO:0065004,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070212,GO:0070412,GO:0070727,GO:0070848,GO:0070887,GO:0070911,GO:0071214,GO:0071241,GO:0071248,GO:0071294,GO:0071310,GO:0071363,GO:0071375,GO:0071417,GO:0071450,GO:0071451,GO:0071478,GO:0071482,GO:0071495,GO:0071559,GO:0071560,GO:0071704,GO:0071824,GO:0071840,GO:0072347,GO:0072521,GO:0072595,GO:0080090,GO:0080134,GO:0080135,GO:0090087,GO:0090092,GO:0090100,GO:0090257,GO:0090304,GO:0090305,GO:0097159,GO:0097305,GO:0097659,GO:0098687,GO:0098781,GO:0104004,GO:0140096,GO:0140097,GO:0140110,GO:1900180,GO:1900182,GO:1900371,GO:1900372,GO:1900407,GO:1900424,GO:1900426,GO:1900542,GO:1900543,GO:1901135,GO:1901214,GO:1901216,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576,GO:1901652,GO:1901653,GO:1901654,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902175,GO:1902531,GO:1902679,GO:1902680,GO:1902882,GO:1903201,GO:1903203,GO:1903376,GO:1903506,GO:1903507,GO:1903508,GO:1903516,GO:1903518,GO:1903530,GO:1903531,GO:1903578,GO:1903579,GO:1903827,GO:1903829,GO:1904044,GO:1904181,GO:1904356,GO:1904357,GO:1904645,GO:1904646,GO:1904760,GO:1904762,GO:1904950,GO:1905076,GO:1905077,GO:1990404,GO:1990837,GO:1990966,GO:2000112,GO:2000113,GO:2000677,GO:2000679,GO:2001020,GO:2001022,GO:2001141,GO:2001169,GO:2001170,GO:2001233,GO:2001242,GO:2001251 2.4.2.30 0.000002143 57.0
HKD2_k127_5187086_31 AAA domain - - - 0.0000247 56.0
HKD2_k127_5187086_32 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02196 GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - 0.0009359 48.0
HKD2_k127_5187086_4 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 376.0
HKD2_k127_5187086_5 MotA/TolQ/ExbB proton channel family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006223 380.0
HKD2_k127_5187086_6 PFAM Patatin K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 366.0
HKD2_k127_5187086_7 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007337 319.0
HKD2_k127_5187086_8 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001606 290.0
HKD2_k127_5187086_9 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000945 262.0
HKD2_k127_5222468_0 Putative amidoligase enzyme (DUF2126) - - - 0.0 1521.0
HKD2_k127_5222468_1 Circularly permuted ATP-grasp type 2 - - - 4.65e-233 731.0
HKD2_k127_5222468_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 483.0
HKD2_k127_5222468_3 A predicted alpha-helical domain with a conserved ER motif. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 368.0
HKD2_k127_5222468_4 PFAM 20S proteasome, A and B subunits K07395 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 327.0
HKD2_k127_5223383_0 Outer membrane receptor K02014 - - 1.767e-214 690.0
HKD2_k127_5223383_1 PQQ-like domain K00114 - 1.1.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 517.0
HKD2_k127_5223383_10 COG3473, Maleate cis-trans isomerase K01799,K06033 - 4.1.1.76,5.2.1.1 0.000000000000000000000000000000000000000000000000000001462 201.0
HKD2_k127_5223383_11 Thioesterase superfamily K19222 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0061522,GO:0071704,GO:1901576,GO:1901661,GO:1901663 3.1.2.28 0.0000000000000000000000000000000000000002259 154.0
HKD2_k127_5223383_12 Cytochrome c - - - 0.0000000000000000000000000000007522 133.0
HKD2_k127_5223383_13 Peptidogalycan biosysnthesis/recognition - - - 0.0000000000000002494 92.0
HKD2_k127_5223383_14 - - - - 0.00000000000005019 76.0
HKD2_k127_5223383_2 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 450.0
HKD2_k127_5223383_3 COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K07303 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008932 437.0
HKD2_k127_5223383_4 Subtilase family K14645 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007205 425.0
HKD2_k127_5223383_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 368.0
HKD2_k127_5223383_6 FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 292.0
HKD2_k127_5223383_7 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000865 219.0
HKD2_k127_5223383_8 - - - - 0.00000000000000000000000000000000000000000000000000000000000001299 218.0
HKD2_k127_5223383_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000008073 229.0
HKD2_k127_5245551_0 PFAM Peptidoglycan-binding domain 1 protein K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004902 437.0
HKD2_k127_5245551_2 - - - - 0.0000000000000000000000005708 109.0
HKD2_k127_5245551_3 Belongs to the ompA family - - - 0.000000000000000007567 91.0
HKD2_k127_5245551_4 - - - - 0.000000000000003855 87.0
HKD2_k127_5245551_5 Domain of unknown function (DUF4136) - - - 0.00000000000001467 81.0
HKD2_k127_5253808_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1269.0
HKD2_k127_5253808_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1065.0
HKD2_k127_5253808_10 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002028 435.0
HKD2_k127_5253808_11 Sigma-54 interaction domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 415.0
HKD2_k127_5253808_12 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008652 396.0
HKD2_k127_5253808_13 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 395.0
HKD2_k127_5253808_14 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 352.0
HKD2_k127_5253808_15 TIGRFAM DNA protecting protein DprA K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009035 329.0
HKD2_k127_5253808_16 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002382 321.0
HKD2_k127_5253808_17 signal transduction histidine kinase K07644,K07649 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 306.0
HKD2_k127_5253808_18 Lysin motif - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 302.0
HKD2_k127_5253808_19 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 295.0
HKD2_k127_5253808_2 PFAM peptidase M3A and M3B, thimet oligopeptidase F K01414 - 3.4.24.70 1.159e-236 750.0
HKD2_k127_5253808_20 PFAM HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000713 289.0
HKD2_k127_5253808_21 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 312.0
HKD2_k127_5253808_22 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007127 284.0
HKD2_k127_5253808_23 DNA-3-methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002184 277.0
HKD2_k127_5253808_24 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000144 253.0
HKD2_k127_5253808_25 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000006453 239.0
HKD2_k127_5253808_26 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000000000000000000000000000000000000000000000000000000000901 208.0
HKD2_k127_5253808_27 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000003038 203.0
HKD2_k127_5253808_28 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000006716 196.0
HKD2_k127_5253808_29 Belongs to the Smg family K03747 - - 0.00000000000000000000000000000000000000000001516 168.0
HKD2_k127_5253808_3 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 4.068e-204 659.0
HKD2_k127_5253808_30 4TM region of pyridine nucleotide transhydrogenase, mitoch K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000006454 163.0
HKD2_k127_5253808_31 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000000000000000001743 168.0
HKD2_k127_5253808_32 Sporulation related domain - - - 0.000000000000000000000000000000000001564 145.0
HKD2_k127_5253808_33 Domain of unknown function (DUF4390) - - - 0.00000000000000000000000000000000001326 145.0
HKD2_k127_5253808_34 - - - - 0.0000000000000000000205 102.0
HKD2_k127_5253808_35 Protein of unknown function (DUF3106) - - - 0.0000000000000001283 89.0
HKD2_k127_5253808_36 Outer membrane efflux protein K15725 - - 0.0000000000001528 85.0
HKD2_k127_5253808_37 - - - - 0.0000000001091 74.0
HKD2_k127_5253808_4 signal transduction histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 624.0
HKD2_k127_5253808_5 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 587.0
HKD2_k127_5253808_6 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 545.0
HKD2_k127_5253808_7 Peptidase inhibitor I9 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008721 550.0
HKD2_k127_5253808_8 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 503.0
HKD2_k127_5253808_9 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00324 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 434.0
HKD2_k127_5258587_0 ATPase FliI YscN family K02412 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 546.0
HKD2_k127_5258587_1 bacterial-type flagellum organization K02413 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000001717 58.0
HKD2_k127_5258587_2 - - - - 0.0000002518 54.0
HKD2_k127_5267515_0 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 6.311e-198 629.0
HKD2_k127_5267515_1 Major facilitator superfamily K05548,K08195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 468.0
HKD2_k127_5267515_10 receptor - - - 0.0000005859 51.0
HKD2_k127_5267515_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004197 441.0
HKD2_k127_5267515_3 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005557 389.0
HKD2_k127_5267515_4 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003283 379.0
HKD2_k127_5267515_5 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000000000000000000000009791 174.0
HKD2_k127_5267515_6 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.00000000000000000000000000000000000000000000007256 184.0
HKD2_k127_5267515_7 lactoylglutathione lyase activity K03088 - - 0.0000000000000000000000000000000000000000000002872 179.0
HKD2_k127_5267515_8 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000000000004262 149.0
HKD2_k127_5267515_9 regulatory protein TetR - - - 0.00000000889 58.0
HKD2_k127_5296980_0 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit - - - 4.795e-265 831.0
HKD2_k127_5296980_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007885 346.0
HKD2_k127_5296980_2 ATPases associated with a variety of cellular activities K02003,K05685 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 323.0
HKD2_k127_5296980_3 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 335.0
HKD2_k127_5296980_4 PFAM CopG domain protein DNA-binding domain protein - - - 0.00000000000000006908 83.0
HKD2_k127_5296980_5 MarR family - - - 0.00002984 52.0
HKD2_k127_5310866_0 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1230.0
HKD2_k127_5310866_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 8.868e-264 823.0
HKD2_k127_5310866_10 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 379.0
HKD2_k127_5310866_11 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 353.0
HKD2_k127_5310866_12 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 336.0
HKD2_k127_5310866_13 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000322 340.0
HKD2_k127_5310866_14 Belongs to the universal ribosomal protein uS2 family K02967 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 333.0
HKD2_k127_5310866_15 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 318.0
HKD2_k127_5310866_16 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 311.0
HKD2_k127_5310866_17 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005841 299.0
HKD2_k127_5310866_18 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002481 289.0
HKD2_k127_5310866_19 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000008838 256.0
HKD2_k127_5310866_2 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 7.113e-195 622.0
HKD2_k127_5310866_20 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000174 234.0
HKD2_k127_5310866_21 peptidase K06194 - - 0.000000000000000000000000000000000000000000000000000003839 200.0
HKD2_k127_5310866_22 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000000000000000000000000000000000000000000001906 168.0
HKD2_k127_5310866_23 Belongs to the CDS family K00981 GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 0.00000000000000000000000000000000000000000001413 180.0
HKD2_k127_5310866_24 Belongs to the skp family K06142 - - 0.00000000000000000000000003145 117.0
HKD2_k127_5310866_25 Protein of unknown function (DUF498/DUF598) - - - 0.00000000000000000000007964 104.0
HKD2_k127_5310866_26 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.000000000000000001499 89.0
HKD2_k127_5310866_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 610.0
HKD2_k127_5310866_4 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 589.0
HKD2_k127_5310866_5 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001308 581.0
HKD2_k127_5310866_6 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 511.0
HKD2_k127_5310866_7 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 443.0
HKD2_k127_5310866_8 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 427.0
HKD2_k127_5310866_9 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 406.0
HKD2_k127_5321729_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1283.0
HKD2_k127_5321729_1 FAD dependent oxidoreductase K06954 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 561.0
HKD2_k127_5321729_10 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002368 268.0
HKD2_k127_5321729_11 AntiSigma factor K07167 - - 0.0000000000000000000000000000000000000000000000000000000000000004827 236.0
HKD2_k127_5321729_12 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000001215 217.0
HKD2_k127_5321729_13 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000000000005354 194.0
HKD2_k127_5321729_14 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000005603 185.0
HKD2_k127_5321729_15 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000002095 171.0
HKD2_k127_5321729_16 membrane - - - 0.000000000000000000000000000000000002062 141.0
HKD2_k127_5321729_17 Protein of unknown function (DUF3240) - - - 0.000000000000000008997 87.0
HKD2_k127_5321729_2 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 479.0
HKD2_k127_5321729_3 Cyclopropane-fatty-acyl-phospholipid synthase K00574 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003971 492.0
HKD2_k127_5321729_4 Fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005971 426.0
HKD2_k127_5321729_5 serine-type exopeptidase activity K01322 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000282 346.0
HKD2_k127_5321729_6 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 324.0
HKD2_k127_5321729_7 Protein of unknown function (DUF1365) K09701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004542 316.0
HKD2_k127_5321729_8 XRE family transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 286.0
HKD2_k127_5321729_9 3-oxo-5-alpha-steroid 4-dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001777 278.0
HKD2_k127_5328536_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 4.77e-272 860.0
HKD2_k127_5333924_0 PFAM tRNA synthetase class II (G H P and S) K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004489 496.0
HKD2_k127_5333924_1 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004851 420.0
HKD2_k127_5333924_2 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000442 302.0
HKD2_k127_5333924_3 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000009422 242.0
HKD2_k127_5333924_4 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000000000000000001408 231.0
HKD2_k127_5333924_5 type IV pilus biogenesis stability protein PilW K02656 - - 0.00000000000000000000000000000000000000000006819 182.0
HKD2_k127_5333924_6 TIGRFAM iron-sulfur cluster assembly protein IscA K13628 - - 0.000000000000000000000000000000000000000005019 156.0
HKD2_k127_5333924_7 protein conserved in bacteria - - - 0.0000000000000000000000000000004502 132.0
HKD2_k127_5333924_8 NifU-like N terminal domain - - - 0.00000000002061 69.0
HKD2_k127_5333924_9 Domain of unknown function (DUF4115) K15539 - - 0.00000000004215 74.0
HKD2_k127_5338028_0 Methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003096 475.0
HKD2_k127_5338028_1 Tannase and feruloyl esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 388.0
HKD2_k127_5338028_10 COG2755 Lysophospholipase L1 and related esterases - - - 0.00000000000000000000000000000000682 148.0
HKD2_k127_5338028_11 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000009105 126.0
HKD2_k127_5338028_12 Domain of unknown function (DUF296) K06934 - - 0.00000000000000000000007825 106.0
HKD2_k127_5338028_13 sequence-specific DNA binding - - - 0.00000000000000003005 91.0
HKD2_k127_5338028_14 Fibronectin type III domain - - - 0.0000000000000008718 79.0
HKD2_k127_5338028_15 Small multidrug resistance protein K11741 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000001021 76.0
HKD2_k127_5338028_16 Universal stress protein family - - - 0.00000000000004371 83.0
HKD2_k127_5338028_17 - - - - 0.00000000002543 75.0
HKD2_k127_5338028_18 polyketide cyclase - - - 0.000000002298 64.0
HKD2_k127_5338028_19 methyltransferase - - - 0.000001426 51.0
HKD2_k127_5338028_2 alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009869 331.0
HKD2_k127_5338028_20 domain protein - - - 0.00001396 59.0
HKD2_k127_5338028_3 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 327.0
HKD2_k127_5338028_4 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000003075 271.0
HKD2_k127_5338028_5 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000001913 243.0
HKD2_k127_5338028_6 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000001096 214.0
HKD2_k127_5338028_7 PFAM SMP-30 Gluconolaconase K01179,K01181,K01218,K02014 - 3.2.1.4,3.2.1.78,3.2.1.8 0.0000000000000000000000000000000000000000009527 180.0
HKD2_k127_5338028_8 aminoglycoside hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.0000000000000000000000000000000000001321 155.0
HKD2_k127_5338028_9 negative regulation of transcription, DNA-templated - GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.00000000000000000000000000000000000186 148.0
HKD2_k127_5378043_0 Pyruvate kinase K00873 - 2.7.1.40 3.724e-244 769.0
HKD2_k127_5378043_1 electron transfer activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 509.0
HKD2_k127_5378043_10 Histidine phosphatase superfamily (branch 1) - - - 0.0000000000000000007346 94.0
HKD2_k127_5378043_2 FMN-dependent dehydrogenase K00101,K00467,K16422 - 1.1.2.3,1.1.3.46,1.13.12.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006577 397.0
HKD2_k127_5378043_3 phosphate regulon transcriptional regulatory protein PhoB K07657 GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000007199 236.0
HKD2_k127_5378043_4 Catalyzes the 2'-O methylation of guanosine at position 18 in tRNA K00556 GO:0001510,GO:0002128,GO:0002938,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008175,GO:0008757,GO:0009020,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0106050,GO:0140098,GO:0140101,GO:1901360 2.1.1.34 0.00000000000000000000000000000000000000000000000000000000000009909 220.0
HKD2_k127_5378043_5 Cell wall-active antibiotics response 4TMS YvqF - - - 0.00000000000000000000000000000000000000000000000000000002317 205.0
HKD2_k127_5378043_6 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000000006022 194.0
HKD2_k127_5378043_7 BON domain - - - 0.000000000000000000000000000000000000000000000001651 184.0
HKD2_k127_5378043_8 - - - - 0.00000000000000000000000000000000000000000004115 164.0
HKD2_k127_5378043_9 Tetratricopeptide repeat - - - 0.0000000000000000000000000000003976 137.0
HKD2_k127_54283_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.783e-241 752.0
HKD2_k127_5434357_0 PQQ enzyme repeat K00117 - 1.1.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 549.0
HKD2_k127_5434357_1 Dihydroxyacetone kinase K00863 - 2.7.1.28,2.7.1.29,4.6.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004824 351.0
HKD2_k127_5434357_2 HAD-superfamily hydrolase, subfamily IA, variant 3 K01091 - 3.1.3.18 0.0000000000000000000000000000000000000000000001654 176.0
HKD2_k127_5434357_3 - - - - 0.00000000000000000000000000000000000001838 160.0
HKD2_k127_545529_0 PUA-like domain K00958 - 2.7.7.4 2.078e-275 857.0
HKD2_k127_545529_1 Sulfite reductase K00381 - 1.8.1.2 4.058e-232 732.0
HKD2_k127_545529_10 ADP binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009902 376.0
HKD2_k127_545529_11 malonyl CoA-acyl carrier protein transacylase K00645,K13935 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 333.0
HKD2_k127_545529_12 acetylesterase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 308.0
HKD2_k127_545529_13 D-arabinono-1,4-lactone oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001967 295.0
HKD2_k127_545529_14 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009879 280.0
HKD2_k127_545529_15 alpha beta - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007351 253.0
HKD2_k127_545529_16 - - - - 0.000000000000000000000000000000000000000000000000000000000000008556 232.0
HKD2_k127_545529_17 protein conserved in bacteria K09958 - - 0.0000000000000000000000000000000000000000000000000000000000004758 217.0
HKD2_k127_545529_18 Alcohol dehydrogenase GroES-like domain K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000000000002341 209.0
HKD2_k127_545529_19 integral membrane protein - - - 0.00000000000000000000000000000000000000000000000001128 188.0
HKD2_k127_545529_2 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 2.041e-198 630.0
HKD2_k127_545529_20 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000001128 185.0
HKD2_k127_545529_21 Bacterial protein of unknown function (DUF934) - - - 0.00000000000000000000000000000000000000000000001353 194.0
HKD2_k127_545529_22 PFAM blue (type 1) copper domain protein - - - 0.00000000000000000000000000000000000000000000003105 178.0
HKD2_k127_545529_23 Putative membrane peptidase family (DUF2324) - - - 0.000000000000000000000000000000000008359 146.0
HKD2_k127_545529_24 DNA-binding transcription factor activity K03892 GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000001542 134.0
HKD2_k127_545529_25 - - - - 0.0000000000007996 79.0
HKD2_k127_545529_26 Protein of unknown function (DUF2849) - - - 0.00000000001109 71.0
HKD2_k127_545529_27 - - - - 0.0000000001396 70.0
HKD2_k127_545529_28 protein conserved in bacteria - - - 0.0006973 45.0
HKD2_k127_545529_3 MFS/sugar transport protein K06902 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 511.0
HKD2_k127_545529_4 phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 507.0
HKD2_k127_545529_5 COG1131 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005891 448.0
HKD2_k127_545529_6 Mo-co oxidoreductase dimerisation domain K17225 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000722 431.0
HKD2_k127_545529_7 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 368.0
HKD2_k127_545529_8 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 376.0
HKD2_k127_545529_9 FMN-dependent dehydrogenase K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 369.0
HKD2_k127_548927_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003045 286.0
HKD2_k127_548927_1 oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002082 253.0
HKD2_k127_548927_2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002151 238.0
HKD2_k127_5492308_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0 1300.0
HKD2_k127_5492308_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 3.391e-255 805.0
HKD2_k127_5492308_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 346.0
HKD2_k127_5492308_11 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 331.0
HKD2_k127_5492308_12 Belongs to the NadC ModD family K00767 GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 307.0
HKD2_k127_5492308_13 Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis K03683 GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003458 282.0
HKD2_k127_5492308_14 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000008265 242.0
HKD2_k127_5492308_15 Urate oxidase N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000006576 222.0
HKD2_k127_5492308_16 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000000000002885 209.0
HKD2_k127_5492308_17 - - - - 0.0000000000000000000000000000000000000000000000000000000007069 205.0
HKD2_k127_5492308_18 Part of a membrane complex involved in electron transport K03617 - - 0.0000000000000000000000000000000000000000000000000001343 198.0
HKD2_k127_5492308_19 Part of a membrane complex involved in electron transport K03613 - - 0.0000000000000000000000000000000000000000000000000002914 194.0
HKD2_k127_5492308_2 PFAM biotin lipoyl attachment domain-containing protein K00382 - 1.8.1.4 8.172e-225 712.0
HKD2_k127_5492308_20 Part of a membrane complex involved in electron transport K03612 - - 0.00000000000000000000000000000000000000000000419 171.0
HKD2_k127_5492308_21 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000000000002145 163.0
HKD2_k127_5492308_22 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000003365 65.0
HKD2_k127_5492308_23 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00008818 55.0
HKD2_k127_5492308_3 Protein tyrosine kinase - - - 2.088e-211 684.0
HKD2_k127_5492308_4 Diguanylate cyclase - - - 3.007e-195 640.0
HKD2_k127_5492308_5 PFAM Type II secretion system protein E - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008401 515.0
HKD2_k127_5492308_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 499.0
HKD2_k127_5492308_7 PFAM Type II secretion system protein E K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003167 425.0
HKD2_k127_5492308_8 Part of a membrane complex involved in electron transport K03614 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005862 370.0
HKD2_k127_5492308_9 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 364.0
HKD2_k127_5525941_0 4-hydroxyphenylacetate 3-hydroxylase C terminal - - - 1.137e-293 908.0
HKD2_k127_5525941_1 COG4993 Glucose dehydrogenase - - - 8.668e-215 692.0
HKD2_k127_5525941_10 N-acetyltransferase K00675 - 2.3.1.118 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001356 279.0
HKD2_k127_5525941_11 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002297 265.0
HKD2_k127_5525941_12 Lactonase, 7-bladed beta-propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000007169 239.0
HKD2_k127_5525941_13 FAD binding domain K03391,K05712 - 1.14.13.127,1.14.13.50 0.00000000000000000000000000000000000000000000000000000154 203.0
HKD2_k127_5525941_14 (Lipo)protein K04754 - - 0.00000000000000000000000000000000000000000000000000003763 198.0
HKD2_k127_5525941_15 NUDIX domain - - - 0.00000000000000000000000000000000000000000000000002485 184.0
HKD2_k127_5525941_16 - - - - 0.000000000000000000000000000000000000000000000001455 190.0
HKD2_k127_5525941_17 methyltransferase - GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016741,GO:0022607,GO:0032259,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071766,GO:0071770,GO:0071840,GO:0071944 - 0.00000000000000000000000000000000000000000009974 170.0
HKD2_k127_5525941_18 PFAM Mammalian cell entry related domain protein K02067 - - 0.000000000000000000000000000000000000001462 153.0
HKD2_k127_5525941_19 ABC-type transport system involved in resistance to organic solvents auxiliary component K07323 - - 0.000000000000000000000000000000000000186 153.0
HKD2_k127_5525941_2 Dehydrogenase K00114 - 1.1.2.8 3.944e-203 648.0
HKD2_k127_5525941_20 YceI-like domain - - - 0.000000000000000000000001793 113.0
HKD2_k127_5525941_21 - - - - 0.0000000000000000000001109 109.0
HKD2_k127_5525941_23 - - - - 0.0000000000000003942 93.0
HKD2_k127_5525941_24 - - - - 0.00000000004825 72.0
HKD2_k127_5525941_25 glycoside hydrolase family 38 K01191 - 3.2.1.24 0.00000001063 63.0
HKD2_k127_5525941_26 - - - - 0.00000001612 68.0
HKD2_k127_5525941_27 FAD binding domain K05712 - 1.14.13.127 0.0000009283 61.0
HKD2_k127_5525941_28 STAS domain K07122 - - 0.000002877 59.0
HKD2_k127_5525941_3 PQQ-like domain K00117 - 1.1.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 583.0
HKD2_k127_5525941_4 metal-dependent hydrolase of the TIM-barrel fold K03392,K10220 - 4.1.1.45,4.2.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 512.0
HKD2_k127_5525941_5 PQQ-like domain K05889 - 1.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 488.0
HKD2_k127_5525941_6 PFAM ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008658 330.0
HKD2_k127_5525941_7 Methylenetetrahydrofolate reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000041 299.0
HKD2_k127_5525941_8 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000321 303.0
HKD2_k127_5525941_9 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006838 306.0
HKD2_k127_557465_0 TonB-dependent Receptor Plug K02014 - - 5.353e-314 983.0
HKD2_k127_557465_1 Metallopeptidase family M24 - - - 4.67e-196 624.0
HKD2_k127_557465_10 response to abiotic stimulus K06867 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009135 268.0
HKD2_k127_557465_11 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000001189 206.0
HKD2_k127_557465_12 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000001298 203.0
HKD2_k127_557465_13 glyoxalase III activity K02005 - - 0.00000000000000000000000000000000000000000000000000001877 194.0
HKD2_k127_557465_14 Alcohol dehydrogenase GroES-like domain K00121 - 1.1.1.1,1.1.1.284 0.0000000000000000000000000000000000000000000022 183.0
HKD2_k127_557465_15 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000000000007716 165.0
HKD2_k127_557465_16 COG3764 Sortase (surface protein transpeptidase) K07284 - 3.4.22.70 0.000000000000000000000000000000000000003158 159.0
HKD2_k127_557465_17 - - - - 0.0000000000000000000000000001099 122.0
HKD2_k127_557465_19 metal cluster binding - - - 0.00000000003116 76.0
HKD2_k127_557465_2 Bacterial virulence protein (VirJ) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 578.0
HKD2_k127_557465_20 Domain of unknown function (DUF1905) - - - 0.0000000001372 68.0
HKD2_k127_557465_21 Serine aminopeptidase, S33 - - - 0.00000002218 63.0
HKD2_k127_557465_3 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 500.0
HKD2_k127_557465_4 Dimerisation domain K09846 - 2.1.1.210 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 412.0
HKD2_k127_557465_5 Aspartyl asparaginyl beta-hydroxylase and related dioxygenases K12979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 354.0
HKD2_k127_557465_6 COG0501 Zn-dependent protease with chaperone function - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002932 327.0
HKD2_k127_557465_7 protein containing a von Willebrand factor type A (vWA) domain K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000645 308.0
HKD2_k127_557465_8 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005877 271.0
HKD2_k127_557465_9 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001427 266.0
HKD2_k127_5592594_0 efflux transmembrane transporter activity K18300,K18308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 354.0
HKD2_k127_5592594_1 efflux pump K18299 - - 0.000000000000000000000000000000000000000001011 159.0
HKD2_k127_559509_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1025.0
HKD2_k127_559509_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 499.0
HKD2_k127_559509_10 DinB family - - - 0.000000000000000000000000000000000000000000000000000000000000002531 229.0
HKD2_k127_559509_11 - - - - 0.00000000000000000000000000000000000000000000000000000000003829 215.0
HKD2_k127_559509_12 TraB family - - - 0.00000000000000000000000000000000000000000000000000000001995 214.0
HKD2_k127_559509_13 Uncharacterized protein family, UPF0114 - - - 0.00000000000000000000000000000000000000000000000000001616 197.0
HKD2_k127_559509_14 Redoxin domain protein - - - 0.00000000000000000000000000000000000000000000000000008001 196.0
HKD2_k127_559509_15 histone H4-K16 acetylation K07020 - - 0.00000000000000000000000000000000000000000000000019 184.0
HKD2_k127_559509_16 membrane protein domain - - - 0.000000000000000000000000000000000000000000000009874 180.0
HKD2_k127_559509_17 Thiol disulfide interchange protein K03673 - - 0.00000000000000000000000000000000000000000000003975 180.0
HKD2_k127_559509_18 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000004532 186.0
HKD2_k127_559509_2 Aldo/keto reductase family K00011 - 1.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007722 344.0
HKD2_k127_559509_21 Diguanylate cyclase, GGDEF domain - - - 0.000000000000000000000000000000000000000005446 175.0
HKD2_k127_559509_22 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000001113 160.0
HKD2_k127_559509_23 PFAM electron transport protein SCO1 SenC K07152 - - 0.000000000000000000000000000000000000001507 160.0
HKD2_k127_559509_24 FtsX-like permease family K02004 - - 0.0000000000000000000000000000004136 130.0
HKD2_k127_559509_25 Winged helix DNA-binding domain - - - 0.000000000000000000000000000003483 123.0
HKD2_k127_559509_26 Carbohydrate family 9 binding domain-like - - - 0.000000000000000000000000000003637 123.0
HKD2_k127_559509_27 Protein conserved in bacteria K09796 - - 0.0000000000000000000004236 103.0
HKD2_k127_559509_28 PFAM sigma-70 region 2 domain protein K03088 - - 0.000000000000000000001126 102.0
HKD2_k127_559509_3 associated with various cellular activities K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 320.0
HKD2_k127_559509_30 - - - - 0.000000000000003436 88.0
HKD2_k127_559509_31 Bacterial protein of unknown function (Gcw_chp) - - - 0.000000000000007364 83.0
HKD2_k127_559509_32 Polymer-forming cytoskeletal - - - 0.00000000000001776 87.0
HKD2_k127_559509_33 regulation of cell-substrate adhesion K06079 - - 0.00000000000133 76.0
HKD2_k127_559509_4 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001715 274.0
HKD2_k127_559509_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006124 256.0
HKD2_k127_559509_6 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806,K12503 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000001759 243.0
HKD2_k127_559509_7 serine protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000005544 254.0
HKD2_k127_559509_8 Signal peptidase, peptidase S26 - - - 0.000000000000000000000000000000000000000000000000000000000000000008912 232.0
HKD2_k127_559509_9 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000176 245.0
HKD2_k127_5620090_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1026.0
HKD2_k127_5620090_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000000000009215 107.0
HKD2_k127_5664674_0 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005157 610.0
HKD2_k127_5664674_1 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002352 556.0
HKD2_k127_5664674_10 DSBA-like thioredoxin domain K07396 - - 0.00000000000000000000000000000000000000000000000000000004295 203.0
HKD2_k127_5664674_11 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000007242 186.0
HKD2_k127_5664674_12 Hemerythrin - - - 0.0000000000000000000000000000000000000003509 155.0
HKD2_k127_5664674_13 PFAM DGPFAETKE family protein - - - 0.0000000000000000000000000000000000000005318 154.0
HKD2_k127_5664674_14 2OG-Fe(II) oxygenase superfamily - - - 0.0000000000000000000000000000000000001572 151.0
HKD2_k127_5664674_15 - - - - 0.0000000000000000000000000001196 123.0
HKD2_k127_5664674_16 Protein of unknown function (DUF1289) - - - 0.000000000000003941 78.0
HKD2_k127_5664674_17 - - - - 0.0000000000003667 75.0
HKD2_k127_5664674_19 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors - - - 0.00001578 52.0
HKD2_k127_5664674_2 PFAM Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000709 512.0
HKD2_k127_5664674_3 NADPH:quinone reductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004513 372.0
HKD2_k127_5664674_4 Belongs to the HpcH HpaI aldolase family K00979,K01630,K02510 - 2.7.7.38,4.1.2.20,4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000009598 257.0
HKD2_k127_5664674_5 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000001367 234.0
HKD2_k127_5664674_6 Lytic polysaccharide mono-oxygenase, cellulose-degrading - - - 0.000000000000000000000000000000000000000000000000000000000000005513 229.0
HKD2_k127_5664674_7 YCII-related domain - - - 0.0000000000000000000000000000000000000000000000000000000000008098 223.0
HKD2_k127_5664674_8 phospholipid-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000001542 213.0
HKD2_k127_5664674_9 Domain of unknown function (DUF4159) - - - 0.000000000000000000000000000000000000000000000000000000000002564 218.0
HKD2_k127_572588_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 1.032e-237 747.0
HKD2_k127_572588_1 COG4993 Glucose dehydrogenase - - - 8.991e-216 691.0
HKD2_k127_572588_2 receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000895 604.0
HKD2_k127_572588_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004819 416.0
HKD2_k127_572588_4 major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003193 402.0
HKD2_k127_572588_5 Retinal pigment epithelial membrane protein K11159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 307.0
HKD2_k127_572588_6 peptidase - - - 0.00000000000000000000000000000000000000000000000000000001218 210.0
HKD2_k127_572588_7 YXWGXW repeat (2 copies) - - - 0.00000000000000000000000186 106.0
HKD2_k127_572588_8 - - - - 0.000000002482 67.0
HKD2_k127_572588_9 - - - - 0.00001094 49.0
HKD2_k127_5757707_0 Amidohydrolase K07045,K14333,K20941 - 4.1.1.103,4.1.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 445.0
HKD2_k127_5757707_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 409.0
HKD2_k127_5757707_2 Sugar (and other) transporter K08195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005376 368.0
HKD2_k127_5757707_3 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000003926 214.0
HKD2_k127_5757707_4 Peptidase family M48 - - - 0.0000000000000000000000002918 120.0
HKD2_k127_5759464_0 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 412.0
HKD2_k127_5759464_1 von Willebrand factor, type A K11912 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006814 349.0
HKD2_k127_5801280_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 0.0 1111.0
HKD2_k127_5801280_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 3.682e-250 786.0
HKD2_k127_5801280_10 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004926 347.0
HKD2_k127_5801280_11 Helix-hairpin-helix domain K04477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 314.0
HKD2_k127_5801280_12 Bacterioferritin (cytochrome b1) K03594 - 1.16.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000005091 279.0
HKD2_k127_5801280_13 alpha beta K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000001568 239.0
HKD2_k127_5801280_14 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.0000000000000000000000000000000000000000000000000000000000007221 222.0
HKD2_k127_5801280_15 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000007312 201.0
HKD2_k127_5801280_17 PFAM Archease protein family (DUF101 UPF0211) K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000004433 181.0
HKD2_k127_5801280_19 pterin-4-alpha-carbinolamine dehydratase K01724 GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 0.00000000000000000000000000000000000000000000003427 172.0
HKD2_k127_5801280_2 Belongs to the RtcB family K14415 - 6.5.1.3 6.645e-217 682.0
HKD2_k127_5801280_20 Cytochrome c - - - 0.00000000000000000000000000003122 123.0
HKD2_k127_5801280_21 Universal stress protein K14055 GO:0000302,GO:0001539,GO:0006928,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0033554,GO:0034599,GO:0034614,GO:0034644,GO:0035690,GO:0040011,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044764,GO:0046677,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071478,GO:0071482,GO:0071973,GO:0097237,GO:0097588,GO:0104004,GO:1901700,GO:1901701 - 0.000000000000000000000000001176 125.0
HKD2_k127_5801280_22 Universal stress protein K14055 GO:0000302,GO:0001539,GO:0006928,GO:0006950,GO:0006979,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0033554,GO:0034599,GO:0034614,GO:0034644,GO:0035690,GO:0040011,GO:0042221,GO:0042493,GO:0042542,GO:0042710,GO:0044010,GO:0044764,GO:0046677,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051704,GO:0051716,GO:0070301,GO:0070887,GO:0071214,GO:0071236,GO:0071478,GO:0071482,GO:0071973,GO:0097237,GO:0097588,GO:0104004,GO:1901700,GO:1901701 - 0.000000000000000000000002803 115.0
HKD2_k127_5801280_23 - - - - 0.0000000000000000000001228 104.0
HKD2_k127_5801280_24 MerR HTH family regulatory protein K18997 - - 0.0000000000000000001303 92.0
HKD2_k127_5801280_26 Phosphopantetheine attachment site - - - 0.000000000000001303 85.0
HKD2_k127_5801280_27 - - - - 0.00000000003912 70.0
HKD2_k127_5801280_28 - - - - 0.0000000002832 65.0
HKD2_k127_5801280_29 glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000002308 58.0
HKD2_k127_5801280_3 L-lactate permease K03303 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000577 619.0
HKD2_k127_5801280_4 Beta-Casp domain K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001552 526.0
HKD2_k127_5801280_5 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 489.0
HKD2_k127_5801280_6 Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit K00162 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002601 488.0
HKD2_k127_5801280_7 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009146 441.0
HKD2_k127_5801280_8 heat shock protein DnaJ K05516 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007601 346.0
HKD2_k127_5801280_9 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 343.0
HKD2_k127_5833082_0 Concanavalin A-like lectin/glucanases superfamily - - - 4.882e-244 781.0
HKD2_k127_5833082_1 - - - - 1.06e-199 636.0
HKD2_k127_5833082_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 424.0
HKD2_k127_5833082_3 XdhC and CoxI family - - - 0.000000000000000000000000000000000000000000000000000000000000001826 234.0
HKD2_k127_5833082_4 GTP cyclohydrolase K01495 - 3.5.4.16 0.000000000000000000000000009298 113.0
HKD2_k127_58640_0 COG0277 FAD FMN-containing dehydrogenases K00102 - 1.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 456.0
HKD2_k127_58640_1 MFS transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 447.0
HKD2_k127_58640_10 Predicted membrane protein (DUF2214) - - - 0.00000000000000000000000000000000008592 155.0
HKD2_k127_58640_11 May be involved in recombination K03554 - - 0.0000000000000000000000000001288 127.0
HKD2_k127_58640_12 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000001173 111.0
HKD2_k127_58640_13 OmpA family K03286 - - 0.0000411 52.0
HKD2_k127_58640_2 cation diffusion facilitator family transporter K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 367.0
HKD2_k127_58640_3 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007391 321.0
HKD2_k127_58640_4 Adenylate cyclase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000003643 280.0
HKD2_k127_58640_5 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002147 251.0
HKD2_k127_58640_6 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000005068 223.0
HKD2_k127_58640_7 protein serine/threonine phosphatase activity K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000005716 196.0
HKD2_k127_58640_8 Domain of unknown function (DUF1820) - - - 0.0000000000000000000000000000000000000001322 153.0
HKD2_k127_58640_9 Type VI secretion K07169,K11894,K11913 - - 0.00000000000000000000000000000000001077 153.0
HKD2_k127_5913417_0 Peptidase C39 family K13409 - - 7.438e-259 820.0
HKD2_k127_5913417_1 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 612.0
HKD2_k127_5913417_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009401 304.0
HKD2_k127_5913417_11 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 316.0
HKD2_k127_5913417_12 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004419 305.0
HKD2_k127_5913417_13 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000001692 243.0
HKD2_k127_5913417_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000006524 228.0
HKD2_k127_5913417_15 Thioredoxin K05838 - - 0.000000000000000000000000000000000000000000000000000000183 203.0
HKD2_k127_5913417_16 gluconolactonase activity K01053 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000001663 203.0
HKD2_k127_5913417_18 PFAM Metal-dependent phosphohydrolase, HD - - - 0.0000000000000000000000000000000001646 140.0
HKD2_k127_5913417_19 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000006346 137.0
HKD2_k127_5913417_2 Belongs to the type-B carboxylesterase lipase family K03929 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000839 561.0
HKD2_k127_5913417_20 Adenylate cyclase - - - 0.000000000000000000000000000000001622 147.0
HKD2_k127_5913417_21 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000002893 138.0
HKD2_k127_5913417_22 - - - - 0.000000000000000000000000000007617 135.0
HKD2_k127_5913417_23 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain K03320 - - 0.00000000000000000000000000003011 132.0
HKD2_k127_5913417_24 Phospholipid methyltransferase - - - 0.0000000000000000000001102 105.0
HKD2_k127_5913417_25 - - - - 0.0000000000000000000007816 106.0
HKD2_k127_5913417_26 Protein of unknown function (DUF2905) - - - 0.000000000000000000002547 94.0
HKD2_k127_5913417_27 Beta-lactamase - - - 0.0000000005257 72.0
HKD2_k127_5913417_3 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002999 519.0
HKD2_k127_5913417_4 synthase component I K01665 - 2.6.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008581 512.0
HKD2_k127_5913417_5 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 503.0
HKD2_k127_5913417_7 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009673 422.0
HKD2_k127_5913417_8 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008068 403.0
HKD2_k127_5913417_9 HlyD family secretion protein K13408 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 334.0
HKD2_k127_60301_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 3.073e-310 972.0
HKD2_k127_60301_1 Squalene--hopene cyclase K06045 - 4.2.1.129,5.4.99.17 1.998e-273 858.0
HKD2_k127_60301_10 Oxidoreductase molybdopterin binding domain K07147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 303.0
HKD2_k127_60301_11 Secreted protein, containing von Willebrand factor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003 296.0
HKD2_k127_60301_12 Aminotransferase class-III K00822,K00833 - 2.6.1.18,2.6.1.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002182 274.0
HKD2_k127_60301_13 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004157 267.0
HKD2_k127_60301_14 Prokaryotic cytochrome b561 - - - 0.000000000000000000000000000000000000000000000000000000000000000002758 236.0
HKD2_k127_60301_15 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000002506 234.0
HKD2_k127_60301_16 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935,K02169 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197,6.3.3.3 0.00000000000000000000000000000000000000000000000000000009264 202.0
HKD2_k127_60301_17 Domain of unknown function (DUF4399) - - - 0.000000000000000000000000000000000000000000104 166.0
HKD2_k127_60301_18 NlpC/P60 family - - - 0.000000000000000000000000005692 119.0
HKD2_k127_60301_19 - - - - 0.00000000000000000000000001641 124.0
HKD2_k127_60301_2 Binding-protein-dependent transport systems inner membrane component K02050 - - 1.762e-223 707.0
HKD2_k127_60301_20 OmpA family - - - 0.000000000000000001718 96.0
HKD2_k127_60301_21 Protein tyrosine kinase K08884,K12132 - 2.7.11.1 0.000000000000000008576 95.0
HKD2_k127_60301_22 - - - - 0.0001228 55.0
HKD2_k127_60301_23 COG1716 FOG FHA domain - - - 0.0001232 54.0
HKD2_k127_60301_3 ABC transporter K02049 - - 1.917e-196 623.0
HKD2_k127_60301_4 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01840,K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004903 623.0
HKD2_k127_60301_5 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 496.0
HKD2_k127_60301_6 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002817 516.0
HKD2_k127_60301_7 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009633 448.0
HKD2_k127_60301_8 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 405.0
HKD2_k127_60301_9 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 334.0
HKD2_k127_604954_0 Sulfate transporter antisigma-factor antagonist STAS - - - 1.492e-231 729.0
HKD2_k127_604954_1 membrane - - - 0.000000000000000000000000000000000000000000000000003422 187.0
HKD2_k127_604954_2 - - - - 0.000000000000000000000000000000000000000002519 168.0
HKD2_k127_604954_3 Glycogen debranching enzyme - - - 0.000000000000000002344 87.0
HKD2_k127_6142566_0 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004388 331.0
HKD2_k127_6142566_1 Participates in transcription elongation, termination and antitermination K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002057 295.0
HKD2_k127_6142566_2 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.000000000000000000000000000000000000000000000000000000000000000000006783 238.0
HKD2_k127_6142566_3 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000004356 192.0
HKD2_k127_6142566_4 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.0000000000000000000000000006686 118.0
HKD2_k127_6142566_5 translation elongation factor activity K02358 - - 0.000000000000000006545 83.0
HKD2_k127_6142566_6 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.0000000008426 60.0
HKD2_k127_6166743_0 FAD linked oxidases, C-terminal domain K18930 - - 0.0 1230.0
HKD2_k127_6166743_1 Belongs to the ABC transporter superfamily K02031,K02032 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 1.603e-305 950.0
HKD2_k127_6166743_10 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 473.0
HKD2_k127_6166743_11 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03670 GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006166 476.0
HKD2_k127_6166743_12 N-terminal TM domain of oligopeptide transport permease C K02034 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009671 396.0
HKD2_k127_6166743_13 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 387.0
HKD2_k127_6166743_14 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 385.0
HKD2_k127_6166743_15 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004749 364.0
HKD2_k127_6166743_16 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000092 302.0
HKD2_k127_6166743_17 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005294 289.0
HKD2_k127_6166743_18 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003488 274.0
HKD2_k127_6166743_19 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004904 288.0
HKD2_k127_6166743_2 - - - - 2.198e-296 926.0
HKD2_k127_6166743_20 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007004 262.0
HKD2_k127_6166743_21 Cystathionine beta-synthase K01697 GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363 4.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000882 267.0
HKD2_k127_6166743_22 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008424 259.0
HKD2_k127_6166743_23 Planctomycete cytochrome C - - - 0.000000000000000000000000000000000000000000000000000000000000000001404 237.0
HKD2_k127_6166743_24 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000007049 223.0
HKD2_k127_6166743_25 MOSC domain - - - 0.0000000000000000000000000000000000000000000000000006841 195.0
HKD2_k127_6166743_26 SMART phosphoesterase PA-phosphatase related - - - 0.00000000000000000000000000000000000000000000000001197 192.0
HKD2_k127_6166743_27 Prolyl 4-hydroxylase alpha subunit homologues. K07336 - - 0.00000000000000000000000000000000000000000000000002615 188.0
HKD2_k127_6166743_28 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000001979 192.0
HKD2_k127_6166743_29 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000001144 196.0
HKD2_k127_6166743_3 phosphoenolpyruvate carboxylase activity K01595 - 4.1.1.31 1.393e-267 854.0
HKD2_k127_6166743_30 sister chromatid segregation - - - 0.00000000000000000000000000000000000000000000001225 181.0
HKD2_k127_6166743_31 - - - - 0.000000000000000000000000000000000000000000003832 180.0
HKD2_k127_6166743_32 cellulase activity - - - 0.00000000000000000000000000000000000000001048 169.0
HKD2_k127_6166743_33 DNA-templated transcription, initiation K03088,K03091 - - 0.00000000000000000000000000000000000000005136 159.0
HKD2_k127_6166743_34 MarC family integral membrane protein K05595 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000008009 166.0
HKD2_k127_6166743_35 Exopolysaccharide synthesis, ExoD - - - 0.000000000000000000000000000000000000003066 162.0
HKD2_k127_6166743_36 Polymer-forming cytoskeletal - - - 0.00000000000000000000000000000000000004468 154.0
HKD2_k127_6166743_37 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000001761 139.0
HKD2_k127_6166743_38 - - - - 0.0000000000000000000000000001199 131.0
HKD2_k127_6166743_39 - - - - 0.0000000000000000000000000004673 124.0
HKD2_k127_6166743_4 Peptidase family M49 K01277 - 3.4.14.4 3.247e-252 795.0
HKD2_k127_6166743_40 - - - - 0.00000000000000000000000001316 115.0
HKD2_k127_6166743_42 - - - - 0.000000000000000007696 100.0
HKD2_k127_6166743_43 transport system, permease component K01992 - - 0.0000000000000003375 93.0
HKD2_k127_6166743_46 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000207 68.0
HKD2_k127_6166743_47 Protein of unknown function (DUF2845) - - - 0.00000003906 64.0
HKD2_k127_6166743_5 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0017038,GO:0022857,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033036,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043295,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072341,GO:1900750,GO:1901681,GO:1904680 - 3.729e-208 661.0
HKD2_k127_6166743_6 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 578.0
HKD2_k127_6166743_7 Glycosyl transferase family group 2 K03669 GO:0005575,GO:0016020 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 609.0
HKD2_k127_6166743_8 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008114 523.0
HKD2_k127_6166743_9 heat shock protein binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 515.0
HKD2_k127_621041_0 PhoQ Sensor K12257 - - 0.0 1596.0
HKD2_k127_621041_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1182.0
HKD2_k127_621041_10 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008494 312.0
HKD2_k127_621041_11 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000973 275.0
HKD2_k127_621041_12 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006411 255.0
HKD2_k127_621041_13 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008924 258.0
HKD2_k127_621041_14 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002146 254.0
HKD2_k127_621041_15 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000008064 214.0
HKD2_k127_621041_16 L,D-transpeptidase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000001411 213.0
HKD2_k127_621041_17 MucB/RseB C-terminal domain K03598 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0044464,GO:0045152 - 0.0000000000000000000000000000000000000000000000000000001314 207.0
HKD2_k127_621041_18 phosphinothricin N-acetyltransferase activity K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000000004231 198.0
HKD2_k127_621041_19 CYTH K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000008089 191.0
HKD2_k127_621041_2 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 2.224e-302 942.0
HKD2_k127_621041_20 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000000000659 191.0
HKD2_k127_621041_21 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000001696 195.0
HKD2_k127_621041_22 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000003962 179.0
HKD2_k127_621041_23 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000002873 173.0
HKD2_k127_621041_24 phosphoribosyltransferase K00760 - 2.4.2.8 0.0000000000000000000000000000000000000000005835 164.0
HKD2_k127_621041_25 Belongs to the GcvT family K06980 - - 0.00000000000000000000000000000000000003078 155.0
HKD2_k127_621041_26 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000001144 138.0
HKD2_k127_621041_27 succinate dehydrogenase K00241 - - 0.0000000000000000000000000004787 118.0
HKD2_k127_621041_28 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0016740,GO:0016772,GO:0016780,GO:0044238,GO:0071704,GO:1901576 2.7.8.7 0.0000000000000000000000003984 115.0
HKD2_k127_621041_29 succinate dehydrogenase, hydrophobic membrane anchor K00242 - - 0.00000000000000000000003184 104.0
HKD2_k127_621041_3 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.02e-281 875.0
HKD2_k127_621041_30 cell redox homeostasis K00384 - 1.8.1.9 0.0000000000005601 75.0
HKD2_k127_621041_31 Flavinator of succinate dehydrogenase K09159 - - 0.000000000002002 70.0
HKD2_k127_621041_32 Peptidoglycan-binding protein, CsiV - - - 0.00000000008879 72.0
HKD2_k127_621041_33 Protein of unknown function (DUF1674) - - - 0.00000002354 62.0
HKD2_k127_621041_34 Transposase - - - 0.0000002889 53.0
HKD2_k127_621041_35 Domain of unknown function (DUF4845) - - - 0.0000004409 57.0
HKD2_k127_621041_36 An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E K03597 GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - 0.0000008791 58.0
HKD2_k127_621041_37 Positive regulator of K03803 GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.0001663 49.0
HKD2_k127_621041_4 Glycosyl transferase family group 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 509.0
HKD2_k127_621041_5 two-component system sensor protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005877 467.0
HKD2_k127_621041_6 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 423.0
HKD2_k127_621041_7 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 425.0
HKD2_k127_621041_8 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 347.0
HKD2_k127_621041_9 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 310.0
HKD2_k127_6218540_0 MacB-like periplasmic core domain - - - 1.218e-218 703.0
HKD2_k127_6218540_1 ABC-type antimicrobial peptide transport system, permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 626.0
HKD2_k127_6218540_2 efflux transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 405.0
HKD2_k127_6218540_3 MacB-like periplasmic core domain - - - 0.0000000000000005877 80.0
HKD2_k127_6238401_0 TonB dependent receptor K02014 - - 3.585e-310 970.0
HKD2_k127_6238401_1 FAD linked oxidase domain protein K05797 - 1.17.99.1 2.033e-214 679.0
HKD2_k127_6238401_10 Glutathione-dependent formaldehyde-activating enzyme K03396 - 4.4.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 309.0
HKD2_k127_6238401_11 Transcriptional regulatory protein, C terminal K07667 GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000002232 254.0
HKD2_k127_6238401_12 Two component transcriptional regulator, winged helix family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000538 242.0
HKD2_k127_6238401_13 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000000000000000000004659 218.0
HKD2_k127_6238401_14 response to abiotic stimulus K06867 - - 0.00000000000000000000000000003279 125.0
HKD2_k127_6238401_15 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000000001311 117.0
HKD2_k127_6238401_16 Belongs to the UPF0235 family K09131 - - 0.00000000001005 70.0
HKD2_k127_6238401_17 - - - - 0.000005072 56.0
HKD2_k127_6238401_18 Bacterial regulatory proteins, tetR family - - - 0.00005236 53.0
HKD2_k127_6238401_2 DNA topological change - - - 1.605e-208 674.0
HKD2_k127_6238401_3 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 419.0
HKD2_k127_6238401_4 histidine kinase HAMP region domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 428.0
HKD2_k127_6238401_5 Bacterial extracellular solute-binding protein K02048 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 435.0
HKD2_k127_6238401_6 ATPase activity K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 417.0
HKD2_k127_6238401_7 sulfate ABC transporter K02047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004562 376.0
HKD2_k127_6238401_8 sulfate ABC transporter, inner membrane subunit CysT K02046,K15496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 340.0
HKD2_k127_6238401_9 Histidine kinase K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004229 336.0
HKD2_k127_627452_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1046.0
HKD2_k127_627452_1 Domain of unknown function (DUF1974) K06445 - - 5.236e-281 885.0
HKD2_k127_627452_10 COG1131 ABC-type multidrug transport system, ATPase component K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007012 407.0
HKD2_k127_627452_11 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 388.0
HKD2_k127_627452_12 alpha/beta hydrolase fold K07019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 318.0
HKD2_k127_627452_13 argininosuccinate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006519 310.0
HKD2_k127_627452_14 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 308.0
HKD2_k127_627452_15 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 292.0
HKD2_k127_627452_16 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005842 294.0
HKD2_k127_627452_17 Carboxylesterase K06999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009284 263.0
HKD2_k127_627452_18 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001469 265.0
HKD2_k127_627452_19 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000006072 259.0
HKD2_k127_627452_2 transporter - - - 4.129e-263 841.0
HKD2_k127_627452_20 Belongs to the ATCase OTCase family K09065,K13043 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.9 0.0000000000000000000000000000000000000000000000000000000000000001579 233.0
HKD2_k127_627452_21 PFAM PspA IM30 family protein K03969 GO:0003674,GO:0005488,GO:0005515,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006950,GO:0008150,GO:0008289,GO:0009266,GO:0009271,GO:0009408,GO:0009605,GO:0009607,GO:0009615,GO:0009628,GO:0009889,GO:0009898,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019897,GO:0019898,GO:0031234,GO:0031323,GO:0031326,GO:0042802,GO:0043167,GO:0043168,GO:0043207,GO:0043433,GO:0044092,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051090,GO:0051171,GO:0051252,GO:0051704,GO:0051707,GO:0060187,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0098552,GO:0098562,GO:0098586,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000001601 233.0
HKD2_k127_627452_22 Belongs to the SOS response-associated peptidase family - - - 0.000000000000000000000000000000000000000000000000000000000001522 230.0
HKD2_k127_627452_23 PFAM cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000002636 216.0
HKD2_k127_627452_24 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.0000000000000000000000000000000000000000000000000006917 187.0
HKD2_k127_627452_25 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000002177 200.0
HKD2_k127_627452_26 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000063 185.0
HKD2_k127_627452_27 Transport and Golgi organisation 2 - - - 0.0000000000000000000000000000000000000000000000007397 183.0
HKD2_k127_627452_28 Transfers electrons from cytochrome c551 to cytochrome oxidase - - - 0.00000000000000000000000000000000000000000005063 169.0
HKD2_k127_627452_29 Thiol disulfide interchange protein K03673 - - 0.00000000000000000000000000000000000000002923 162.0
HKD2_k127_627452_3 COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2 K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 525.0
HKD2_k127_627452_30 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000007573 98.0
HKD2_k127_627452_31 Regulates arginine biosynthesis genes K03402 - - 0.00000000000000000007583 102.0
HKD2_k127_627452_32 Phage shock protein B K03970 - - 0.000000000000000004623 86.0
HKD2_k127_627452_33 phage shock protein C K03973 - - 0.0000000000000001583 84.0
HKD2_k127_627452_34 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.00000000001723 72.0
HKD2_k127_627452_35 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03425 GO:0002790,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009977,GO:0009987,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0000000007844 62.0
HKD2_k127_627452_37 Type II secretion system protein B K02451 - - 0.00002599 55.0
HKD2_k127_627452_38 - - - - 0.0001879 47.0
HKD2_k127_627452_39 Belongs to the heme-copper respiratory oxidase family K02274 - 1.9.3.1 0.0002762 46.0
HKD2_k127_627452_4 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 460.0
HKD2_k127_627452_5 Aminotransferase class-V K14287 - 2.6.1.88 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002229 474.0
HKD2_k127_627452_6 TIGRFAM amino acid peptide transporter (Peptide H symporter), bacterial K03305 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008699 448.0
HKD2_k127_627452_7 Sigma-54 interaction domain K03974 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 426.0
HKD2_k127_627452_8 Peptidoglycan-binding domain 1 protein K02450 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001808 430.0
HKD2_k127_627452_9 sensor diguanylate cyclase phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 431.0
HKD2_k127_6290603_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001102 286.0
HKD2_k127_6400343_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 589.0
HKD2_k127_6400343_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005212 381.0
HKD2_k127_6415454_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 5.912e-209 665.0
HKD2_k127_6415454_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000172 251.0
HKD2_k127_6415454_2 Uncharacterized protein conserved in bacteria (DUF2059) K09924 - - 0.000000000000000000000000001665 119.0
HKD2_k127_6415454_3 - - - - 0.000000000000000000000001678 107.0
HKD2_k127_6415454_4 - - - - 0.00000000000000000002064 101.0
HKD2_k127_6415454_5 Protein of unknown function (DUF1161) - - - 0.0000000000000002086 89.0
HKD2_k127_6415454_6 - - - - 0.0000000000004688 81.0
HKD2_k127_6415454_7 - - - - 0.0000000003746 68.0
HKD2_k127_6425056_0 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002765 478.0
HKD2_k127_6425056_1 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840 3.1.4.53 0.00000000000000000000000000000000000000000000000000000000001403 215.0
HKD2_k127_6425056_2 TraB family K09973 - - 0.0000000000000000000000000000000000000000000001203 188.0
HKD2_k127_6425056_3 peptidase S16, lon K07157 - - 0.00000000000000000000000000000000000002053 162.0
HKD2_k127_6425056_4 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.00000000000000000000000005288 108.0
HKD2_k127_6429290_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 1.772e-295 919.0
HKD2_k127_6429290_1 Mg-protoporphyrin IX monomethyl ester oxidative cyclase K04034 - 1.21.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 588.0
HKD2_k127_6429290_10 Carboxylesterase family - - - 0.00000000000000000000000000000000000000000005528 174.0
HKD2_k127_6429290_11 Domain of unknown function (DUF1330) - - - 0.00000000000000000000000000001341 122.0
HKD2_k127_6429290_12 Cupin 2, conserved barrel domain protein K11477 - - 0.00000000000000000000001138 117.0
HKD2_k127_6429290_13 HIT domain - - - 0.0000000000000002524 87.0
HKD2_k127_6429290_15 YjbR - - - 0.0000000000006334 76.0
HKD2_k127_6429290_16 Uncharacterised nucleotidyltransferase - - - 0.00002489 57.0
HKD2_k127_6429290_17 MmgE/PrpD family - - - 0.00008879 48.0
HKD2_k127_6429290_2 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007211 533.0
HKD2_k127_6429290_3 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003354 541.0
HKD2_k127_6429290_4 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 441.0
HKD2_k127_6429290_5 SMART transcription factor jumonji jmjC K18850 - 1.14.11.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 424.0
HKD2_k127_6429290_6 HlyD family secretion protein K01993 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 324.0
HKD2_k127_6429290_7 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000009074 234.0
HKD2_k127_6429290_8 PFAM glutathione-dependent formaldehyde-activating GFA - - - 0.000000000000000000000000000000000000000000000000000000000000000001736 230.0
HKD2_k127_6429290_9 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000000000003505 204.0
HKD2_k127_6449122_0 Glycogen debranching enzyme - - - 0.0 1431.0
HKD2_k127_6449122_1 Belongs to the ClpA ClpB family K03694 - - 0.0 1051.0
HKD2_k127_6449122_10 mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 347.0
HKD2_k127_6449122_11 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000157 310.0
HKD2_k127_6449122_12 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006841 284.0
HKD2_k127_6449122_13 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.0000000000000000000000000000000000000000001229 168.0
HKD2_k127_6449122_14 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000000000000008703 156.0
HKD2_k127_6449122_15 Type II secretion system protein C - - - 0.00000000000000000000000000000000000000003375 166.0
HKD2_k127_6449122_16 Sugar efflux transporter for intercellular exchange - - - 0.00000000000000000000000000000000000000005841 155.0
HKD2_k127_6449122_17 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000000101 136.0
HKD2_k127_6449122_18 Histidine-specific methyltransferase, SAM-dependent - - - 0.00000000000000000000146 96.0
HKD2_k127_6449122_19 ABC transporter K02003 - - 0.000000000000000000005986 93.0
HKD2_k127_6449122_2 DNA segregation ATPase FtsK SpoIIIE K03466 - - 2.552e-272 857.0
HKD2_k127_6449122_20 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.00000000000000001002 84.0
HKD2_k127_6449122_21 PFAM VanZ - - - 0.0000000000001503 75.0
HKD2_k127_6449122_22 Histidine-specific methyltransferase, SAM-dependent - - - 0.00000000007831 69.0
HKD2_k127_6449122_3 A predicted alpha-helical domain with a conserved ER motif. - - - 3.348e-221 714.0
HKD2_k127_6449122_4 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 1.061e-200 639.0
HKD2_k127_6449122_5 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003409 563.0
HKD2_k127_6449122_6 General Secretion Pathway protein K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006605 489.0
HKD2_k127_6449122_7 Peptidogalycan biosysnthesis/recognition K09919 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 419.0
HKD2_k127_6449122_8 General secretion pathway protein K02455 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 415.0
HKD2_k127_6449122_9 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 393.0
HKD2_k127_6457731_0 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582 - 3.1.11.5 2.539e-220 723.0
HKD2_k127_6457731_1 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004987 625.0
HKD2_k127_6457731_10 PFAM Endonuclease Exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000419 282.0
HKD2_k127_6457731_11 PFAM Aminotransferase, class IV K02619 - 4.1.3.38 0.0000000000000000000000000000000000000000000000000000000000000000009748 241.0
HKD2_k127_6457731_12 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000000000000000000000000000000000000000000000000000000000001137 229.0
HKD2_k127_6457731_13 Type II secretion system (T2SS), protein K K02460 - - 0.0000000000000000000000000000000000000000000000000000000000002137 232.0
HKD2_k127_6457731_14 Pilus assembly protein PilZ K02676 - - 0.0000000000000000000000000000000000000000000000001218 179.0
HKD2_k127_6457731_15 General Secretion Pathway protein K02456 - - 0.0000000000000000000000000000000000000000000001547 175.0
HKD2_k127_6457731_16 peptidase M48, Ste24p - - - 0.0000000000000000000000000000000000000000000005519 178.0
HKD2_k127_6457731_17 Thioredoxin-like - - - 0.000000000000000000000000000000000000002859 152.0
HKD2_k127_6457731_18 DNA polymerase III, delta' K02341 - 2.7.7.7 0.00000000000000000000000000000002586 143.0
HKD2_k127_6457731_19 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0050896,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.0000000000000000000000000000004236 124.0
HKD2_k127_6457731_2 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 573.0
HKD2_k127_6457731_20 Type II secretion system (T2SS), protein J K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - 0.0000000000000000000000000000009028 134.0
HKD2_k127_6457731_21 Transcriptional regulator K21747 - - 0.0000000000000000000000000002067 128.0
HKD2_k127_6457731_22 proteolysis - - - 0.0000000000000000000000000007974 121.0
HKD2_k127_6457731_23 Spore Coat Protein U domain - - - 0.0000000000000000000000001156 121.0
HKD2_k127_6457731_24 GspL periplasmic domain - - - 0.000000000000000000000003478 116.0
HKD2_k127_6457731_25 Domain of unknown function (DUF4266) - - - 0.00000000000000000000005303 103.0
HKD2_k127_6457731_26 Type II transport protein GspH K02457 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.0000000000000000000006439 104.0
HKD2_k127_6457731_27 Pili and flagellar-assembly chaperone, PapD N-terminal domain K07346 - - 0.00000000000000005443 93.0
HKD2_k127_6457731_28 secreted protein - - - 0.00000000000000007471 87.0
HKD2_k127_6457731_29 MTH538 TIR-like domain (DUF1863) - - - 0.00000000000000214 82.0
HKD2_k127_6457731_3 outer membrane usher protein K07347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 376.0
HKD2_k127_6457731_30 Type II secretion system, protein N K02463 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.0000000324 64.0
HKD2_k127_6457731_31 Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins K02462 - - 0.00000009765 64.0
HKD2_k127_6457731_32 PFAM type II secretion system protein I J K02458 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - 0.0000001114 60.0
HKD2_k127_6457731_33 Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors K12973 - 2.3.1.251 0.0001612 50.0
HKD2_k127_6457731_4 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002747 349.0
HKD2_k127_6457731_5 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003008 329.0
HKD2_k127_6457731_6 Protein of unknown function (DUF3570) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004465 334.0
HKD2_k127_6457731_7 ApbE family K03734 - 2.7.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 323.0
HKD2_k127_6457731_8 KR domain K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0030497,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 310.0
HKD2_k127_6457731_9 glycerophosphodiester phosphodiesterase activity K01126 GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008081,GO:0008889,GO:0009279,GO:0016020,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044462,GO:0044464,GO:0046872,GO:0071944 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008162 308.0
HKD2_k127_6459689_0 anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000002613 255.0
HKD2_k127_6459689_1 - - - - 0.0000000000000000000000000000000000000005552 158.0
HKD2_k127_6459689_2 Thioredoxin-like - - - 0.000000000000000000000000342 108.0
HKD2_k127_6459689_3 Anaerobic ribonucleoside-triphosphate reductase - - - 0.000000000000000000004099 93.0
HKD2_k127_6513638_0 PFAM FAD dependent oxidoreductase K00111 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 606.0
HKD2_k127_6513638_1 PFAM asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 431.0
HKD2_k127_6513638_2 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 350.0
HKD2_k127_6513638_3 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003099 246.0
HKD2_k127_6513638_4 Glycosyltransferase Family 4 K13668 - 2.4.1.346 0.00000000000000000000000000000000001071 142.0
HKD2_k127_6517853_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K07303 - 1.3.99.16 8.062e-222 713.0
HKD2_k127_6517853_1 'PFAM Alpha amylase, catalytic K00690 GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006066,GO:0006073,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016757,GO:0019400,GO:0019751,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0051472,GO:0071704,GO:1901615 2.4.1.7 2.918e-210 664.0
HKD2_k127_6517853_10 Transcriptional regulator sugar kinase K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 315.0
HKD2_k127_6517853_11 COG0477 Permeases of the major facilitator superfamily K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001187 258.0
HKD2_k127_6517853_12 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000001594 239.0
HKD2_k127_6517853_13 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000001104 222.0
HKD2_k127_6517853_14 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000000000001113 224.0
HKD2_k127_6517853_15 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000000000000000000000471 192.0
HKD2_k127_6517853_16 transcriptional regulator - - - 0.0000000000000000000000000000001483 127.0
HKD2_k127_6517853_17 protein conserved in bacteria K01790 GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044764,GO:0051704 5.1.3.13 0.0000000000000000000001029 102.0
HKD2_k127_6517853_18 Sugar (and other) transporter - - - 0.0000000000003462 72.0
HKD2_k127_6517853_19 Prolyl oligopeptidase family - - - 0.0004865 51.0
HKD2_k127_6517853_2 Feruloyl esterase K21105 - 3.1.1.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 561.0
HKD2_k127_6517853_3 alpha/beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 470.0
HKD2_k127_6517853_4 major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007086 469.0
HKD2_k127_6517853_6 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 385.0
HKD2_k127_6517853_7 periplasmic binding protein LacI transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 347.0
HKD2_k127_6517853_8 esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000408 344.0
HKD2_k127_6517853_9 dienelactone hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007184 338.0
HKD2_k127_6519462_0 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 552.0
HKD2_k127_6519462_1 short chain dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 545.0
HKD2_k127_6519462_10 Aminomethyltransferase folate-binding domain K15064 - - 0.000000000000000000004769 93.0
HKD2_k127_6519462_12 Protein of unknown function (DUF3185) - - - 0.000000000005866 69.0
HKD2_k127_6519462_13 - - - - 0.0000000002197 71.0
HKD2_k127_6519462_14 PFAM 3-carboxy-cis,cis-muconate lactonizing enzyme K07404 - 3.1.1.31 0.000000003682 70.0
HKD2_k127_6519462_15 WD domain, G-beta repeat - - - 0.00000155 61.0
HKD2_k127_6519462_16 Regulatory protein, FmdB family - - - 0.00000837 55.0
HKD2_k127_6519462_17 Belongs to the peptidase M28 family - - - 0.00005865 56.0
HKD2_k127_6519462_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005269 409.0
HKD2_k127_6519462_3 PFAM Tannase and feruloyl esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 337.0
HKD2_k127_6519462_4 TonB dependent receptor K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007598 299.0
HKD2_k127_6519462_5 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003298 285.0
HKD2_k127_6519462_6 PepSY-associated TM region - - - 0.0000000000000000000000000000000008676 143.0
HKD2_k127_6519462_7 Gluconate 2-dehydrogenase subunit 3 K06152 - 1.1.99.3 0.00000000000000000000000000001483 128.0
HKD2_k127_6519462_8 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000000000000189 117.0
HKD2_k127_6519462_9 transglycosylase associated protein - - - 0.0000000000000000000000003515 106.0
HKD2_k127_652063_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 3.233e-219 690.0
HKD2_k127_652063_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 332.0
HKD2_k127_652063_2 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000004179 253.0
HKD2_k127_652063_3 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000007711 237.0
HKD2_k127_652063_4 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000002748 186.0
HKD2_k127_652063_5 Colicin v production K03558 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - 0.000000000000000000000000001205 119.0
HKD2_k127_652063_6 PFAM Sporulation K03749 - - 0.000000000000005419 83.0
HKD2_k127_6523883_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 2.436e-242 795.0
HKD2_k127_6523883_1 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 7.744e-195 628.0
HKD2_k127_6523883_2 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 289.0
HKD2_k127_6523883_3 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003229 308.0
HKD2_k127_6523883_4 COG2755 Lysophospholipase L1 and related esterases K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000007014 228.0
HKD2_k127_6540885_0 Fumarylacetoacetate (FAA) hydrolase family K16171 - 3.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009487 384.0
HKD2_k127_6540885_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 395.0
HKD2_k127_6540885_2 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000724 377.0
HKD2_k127_6540885_3 Uncharacterized protein family UPF0016 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 293.0
HKD2_k127_6540885_4 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004698 270.0
HKD2_k127_6540885_5 Glutathione S-transferase, N-terminal domain - - - 0.00000000000005069 78.0
HKD2_k127_6540885_6 membrane - - - 0.00000009913 58.0
HKD2_k127_6540885_7 COG0346 Lactoylglutathione lyase and related lyases - - - 0.00008419 48.0
HKD2_k127_6543774_0 Phosphate transporter family K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 462.0
HKD2_k127_6543774_1 Aspartate tyrosine aromatic aminotransferase K00813,K00832 - 2.6.1.1,2.6.1.57 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009329 438.0
HKD2_k127_6543774_10 Glutathione peroxidase K02199 - - 0.000000000000000000000000000002873 131.0
HKD2_k127_6543774_11 thiosulfate sulfurtransferase activity - - - 0.0000000000000000000000000003843 114.0
HKD2_k127_6543774_12 regulation of cobalamin metabolic process K11390 GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0008150,GO:0009987,GO:0016043,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0019222,GO:0022607,GO:0030656,GO:0031323,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0046872,GO:0046912,GO:0047777,GO:0050789,GO:0050794,GO:0051171,GO:0051193,GO:0051259,GO:0051260,GO:0062012,GO:0065003,GO:0065007,GO:0070206,GO:0070207,GO:0071840,GO:0106064,GO:1901401 - 0.000000000000000000001333 102.0
HKD2_k127_6543774_13 Methyltransferase domain - - - 0.0000000008855 65.0
HKD2_k127_6543774_14 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000257 60.0
HKD2_k127_6543774_3 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009192 409.0
HKD2_k127_6543774_4 NADPH:quinone reductase activity K00344 GO:0000166,GO:0003674,GO:0003824,GO:0003960,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0010941,GO:0016491,GO:0016651,GO:0016655,GO:0019362,GO:0019637,GO:0034641,GO:0036094,GO:0042802,GO:0042803,GO:0042981,GO:0043067,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0048038,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0051186,GO:0055086,GO:0055114,GO:0065007,GO:0070402,GO:0071704,GO:0072524,GO:0097159,GO:1901265,GO:1901360,GO:1901363,GO:1901564 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008118 371.0
HKD2_k127_6543774_5 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000001721 269.0
HKD2_k127_6543774_6 phosphate transport regulator K07220 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004303 244.0
HKD2_k127_6543774_7 COG2015, Alkyl sulfatase and related hydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000001925 241.0
HKD2_k127_6543774_8 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000002265 198.0
HKD2_k127_6543774_9 regulation of RNA biosynthetic process - - - 0.000000000000000000000000000000000000000002667 157.0
HKD2_k127_6568736_0 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 581.0
HKD2_k127_6568736_1 beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 536.0
HKD2_k127_6568736_10 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 313.0
HKD2_k127_6568736_11 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 299.0
HKD2_k127_6568736_12 Phosphotransferase enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005016 261.0
HKD2_k127_6568736_13 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001881 264.0
HKD2_k127_6568736_14 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002106 246.0
HKD2_k127_6568736_15 peroxidase activity K00435 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004063 259.0
HKD2_k127_6568736_16 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749,K13542 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.107,2.5.1.61,4.2.1.75 0.00000000000000000000000000000000000000000000000000000169 216.0
HKD2_k127_6568736_17 - - - - 0.00000000000000000000000000000000000000000000000000003748 197.0
HKD2_k127_6568736_18 Putative FMN-binding domain - - - 0.0000000000000000000000000000000000000000000000000001466 195.0
HKD2_k127_6568736_19 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000003213 163.0
HKD2_k127_6568736_2 carboxylic ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 470.0
HKD2_k127_6568736_20 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.000000000000000000000000000000000000006211 150.0
HKD2_k127_6568736_21 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000000001992 150.0
HKD2_k127_6568736_22 signal transduction histidine kinase - - - 0.0000000000000000000000000000000000002824 158.0
HKD2_k127_6568736_23 - - - - 0.0000000000000000000000000000008859 135.0
HKD2_k127_6568736_24 - - - - 0.0000000000000000000001753 105.0
HKD2_k127_6568736_25 ABC-2 family transporter protein - - - 0.00000000000000000001131 107.0
HKD2_k127_6568736_26 - - - - 0.000000000000000000579 95.0
HKD2_k127_6568736_27 Bacterial protein of unknown function (DUF945) - - - 0.0000000000000001093 94.0
HKD2_k127_6568736_28 - - - - 0.0000000000000005375 91.0
HKD2_k127_6568736_29 PFAM Uroporphyrinogen III synthase HEM4 K01719 - 4.2.1.75 0.0000000000008089 80.0
HKD2_k127_6568736_3 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001901 443.0
HKD2_k127_6568736_30 Calcineurin-like phosphoesterase K07098 - - 0.000000000002051 69.0
HKD2_k127_6568736_31 - - - - 0.0004132 43.0
HKD2_k127_6568736_32 COG0346 Lactoylglutathione lyase and related lyases - - - 0.0005956 51.0
HKD2_k127_6568736_33 Glyoxalase-like domain - - - 0.0005956 51.0
HKD2_k127_6568736_4 Glucose / Sorbosone dehydrogenase K00117,K21430 - 1.1.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 417.0
HKD2_k127_6568736_5 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006493 357.0
HKD2_k127_6568736_6 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003559 358.0
HKD2_k127_6568736_7 Transcriptional regulator K13634 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 342.0
HKD2_k127_6568736_8 ABC-type multidrug transport system, ATPase component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007359 343.0
HKD2_k127_6568736_9 Belongs to the PAPS reductase family. CysH subfamily K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 326.0
HKD2_k127_65724_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 547.0
HKD2_k127_6597266_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 2.649e-300 951.0
HKD2_k127_6597266_1 Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides K10011 - 1.1.1.305,2.1.2.13 7.292e-296 921.0
HKD2_k127_6597266_10 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000006476 179.0
HKD2_k127_6597266_11 glycosyl transferase, family 39 - - - 0.000000000000000000000000000000000000003388 169.0
HKD2_k127_6597266_12 PFAM Outer membrane efflux protein - - - 0.0000000000000000000000000000005388 140.0
HKD2_k127_6597266_13 Phenazine biosynthesis-like protein - - - 0.0000000000000000000000000000005565 125.0
HKD2_k127_6597266_14 Diacylglycerol kinase K00901 - 2.7.1.107 0.00000000000000000000000000003938 124.0
HKD2_k127_6597266_15 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000001385 116.0
HKD2_k127_6597266_16 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000002111 105.0
HKD2_k127_6597266_17 Permeases of the drug metabolite transporter (DMT) superfamily K12962 - - 0.00000000000000001526 93.0
HKD2_k127_6597266_18 PFAM phosphoesterase, PA-phosphatase related - - - 0.000000000000005735 87.0
HKD2_k127_6597266_19 COG0457 FOG TPR repeat - - - 0.0000000009299 71.0
HKD2_k127_6597266_2 Catalyzes the conversion of UDP-4-keto-arabinose (UDP- Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides K07806 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0008483,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:0099620,GO:1901363 2.6.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009818 487.0
HKD2_k127_6597266_20 Small Multidrug Resistance protein - - - 0.0000004173 61.0
HKD2_k127_6597266_3 PFAM ABC transporter related K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006468 390.0
HKD2_k127_6597266_4 Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides K10012 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0044464,GO:0071944,GO:0099621 2.4.2.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008879 384.0
HKD2_k127_6597266_5 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides K13014 GO:0005575,GO:0008150,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0016020,GO:0042221,GO:0050896 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 330.0
HKD2_k127_6597266_6 Putative ABC exporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001054 341.0
HKD2_k127_6597266_7 Acyl-CoA dehydrogenase, C-terminal domain K16047 - 1.14.14.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001674 325.0
HKD2_k127_6597266_8 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001383 297.0
HKD2_k127_6597266_9 alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000003944 209.0
HKD2_k127_6633427_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 6.554e-302 933.0
HKD2_k127_6633427_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 524.0
HKD2_k127_6633427_10 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000000000000000007643 130.0
HKD2_k127_6633427_11 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000003458 126.0
HKD2_k127_6633427_12 GtrA-like protein - - - 0.00000000000000000001469 97.0
HKD2_k127_6633427_13 - - - - 0.0000000000000000002874 93.0
HKD2_k127_6633427_14 COG2931 RTX toxins and related Ca2 -binding proteins K11005 - - 0.000000000000000001027 95.0
HKD2_k127_6633427_15 PRC-barrel domain - - - 0.00000000000000001719 95.0
HKD2_k127_6633427_16 - - - - 0.000000000000001324 87.0
HKD2_k127_6633427_17 - - - - 0.0000000000004646 81.0
HKD2_k127_6633427_18 Forkhead associated domain - - - 0.000000000583 71.0
HKD2_k127_6633427_19 - - - - 0.0006186 51.0
HKD2_k127_6633427_2 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 492.0
HKD2_k127_6633427_3 Putative esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 312.0
HKD2_k127_6633427_4 Platelet-activating factor acetylhydrolase, plasma intracellular isoform II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 300.0
HKD2_k127_6633427_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001879 284.0
HKD2_k127_6633427_6 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000736 263.0
HKD2_k127_6633427_7 nuclear chromosome segregation - - - 0.00000000000000000000000000000000000000000000000000000000000000001078 243.0
HKD2_k127_6633427_8 SMP-30/Gluconolaconase/LRE-like region - - - 0.0000000000000000000000000000000000000000008261 169.0
HKD2_k127_6633427_9 - - - - 0.00000000000000000000000000000000000297 150.0
HKD2_k127_6665228_0 xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 1.614e-233 747.0
HKD2_k127_6665228_1 Aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 478.0
HKD2_k127_6665228_2 Enoyl-CoA hydratase/isomerase K18383 - 4.1.2.41,4.2.1.101 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001428 331.0
HKD2_k127_6665228_3 Ethyl tert-butyl ether degradation - - - 0.0000000000000000000000000000000000000003244 156.0
HKD2_k127_6683544_0 PFAM ABC transporter related K06148 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 411.0
HKD2_k127_6683544_1 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 - 2.7.7.13,5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 380.0
HKD2_k127_6683544_2 transferase activity, transferring glycosyl groups K00754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007437 283.0
HKD2_k127_6683544_3 Polysaccharide pyruvyl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000006953 241.0
HKD2_k127_6683544_4 coenzyme F390 K01912 - 6.2.1.30 0.000000000000000000000002617 117.0
HKD2_k127_6683544_5 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000006332 112.0
HKD2_k127_6683544_6 Protein involved in outer membrane biogenesis - - - 0.000000000000000000002656 102.0
HKD2_k127_6683544_7 - - - - 0.00003455 55.0
HKD2_k127_6690652_0 PFAM AsmA family protein K07289 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009043 334.0
HKD2_k127_6690652_1 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 308.0
HKD2_k127_6690652_2 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 300.0
HKD2_k127_6690652_3 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000004444 230.0
HKD2_k127_6690652_4 COG1194 A G-specific DNA glycosylase K03575 GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000001502 145.0
HKD2_k127_6690652_5 Histidine kinase - - - 0.00000000000000000000000000000000000137 157.0
HKD2_k127_6690652_6 Universal stress protein family - - - 0.000000000000000000000000000002417 125.0
HKD2_k127_6690652_7 Nitroreductase family - - - 0.000000000000000000000000001502 114.0
HKD2_k127_6691593_0 Peptidase family M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 554.0
HKD2_k127_6691593_1 COG2030 Acyl dehydratase - - - 0.0000000000000000000000000000000000000000000000000002236 193.0
HKD2_k127_6691593_2 Signal transduction protein - - - 0.000000000000000000000000000000006809 135.0
HKD2_k127_6714345_0 - - - - 0.00001009 55.0
HKD2_k127_6714345_1 response regulator - - - 0.00004545 51.0
HKD2_k127_6714345_2 chitin binding - - - 0.0004623 46.0
HKD2_k127_6726031_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 3.35e-320 994.0
HKD2_k127_6726031_1 Required for chromosome condensation and partitioning K03529 - - 3.156e-305 974.0
HKD2_k127_6726031_10 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 402.0
HKD2_k127_6726031_11 Patatin-like phospholipase K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007777 404.0
HKD2_k127_6726031_12 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 371.0
HKD2_k127_6726031_13 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 336.0
HKD2_k127_6726031_14 Asparagine synthase K01953 - 6.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005172 333.0
HKD2_k127_6726031_15 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005011 301.0
HKD2_k127_6726031_16 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007954 299.0
HKD2_k127_6726031_17 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 GO:0000166,GO:0002097,GO:0003674,GO:0005488,GO:0005524,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001268 269.0
HKD2_k127_6726031_18 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000001594 238.0
HKD2_k127_6726031_19 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000001939 215.0
HKD2_k127_6726031_2 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.737e-292 924.0
HKD2_k127_6726031_20 - - - - 0.00000000000000000000000000000000000000000000000000000002932 213.0
HKD2_k127_6726031_21 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000009202 205.0
HKD2_k127_6726031_22 Thioredoxin - - - 0.000000000000000000000000000000000000000000000000000009334 197.0
HKD2_k127_6726031_23 Belongs to the UPF0311 family - - - 0.0000000000000000000000000000000000000000000000000000887 198.0
HKD2_k127_6726031_24 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression K06204 - - 0.000000000000000000000000000000000000000000000000000248 194.0
HKD2_k127_6726031_25 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000003818 194.0
HKD2_k127_6726031_26 6-phosphogluconolactonase K00851,K01057 - 2.7.1.12,3.1.1.31 0.000000000000000000000000000000000000000000000000008243 188.0
HKD2_k127_6726031_27 heme binding K08259 - 3.4.24.75 0.00000000000000000000000000000000000000000000000001251 191.0
HKD2_k127_6726031_28 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000002315 165.0
HKD2_k127_6726031_29 Required for maturation of 30S ribosomal subunits K09748 - - 0.0000000000000000000000000000000000009205 144.0
HKD2_k127_6726031_3 PQQ enzyme repeat K00114 - 1.1.2.8 3.509e-244 771.0
HKD2_k127_6726031_30 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000000000004624 134.0
HKD2_k127_6726031_31 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000009271 148.0
HKD2_k127_6726031_32 - - - - 0.000000000000000000000000008291 124.0
HKD2_k127_6726031_33 - - - - 0.000000000000000000000006135 117.0
HKD2_k127_6726031_34 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000003841 94.0
HKD2_k127_6726031_35 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins K03528 - - 0.00000000000000004459 90.0
HKD2_k127_6726031_37 Polysaccharide pyruvyl transferase - - - 0.00005225 54.0
HKD2_k127_6726031_4 Participates in both transcription termination and antitermination K02600 - - 1.65e-216 682.0
HKD2_k127_6726031_5 Fungal trichothecene efflux pump (TRI12) - - - 8.228e-216 679.0
HKD2_k127_6726031_6 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 537.0
HKD2_k127_6726031_7 Chalcone and stilbene synthases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 475.0
HKD2_k127_6726031_8 Belongs to the beta-ketoacyl-ACP synthases family K09458,K14660 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006841 462.0
HKD2_k127_6726031_9 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 431.0
HKD2_k127_6760559_0 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005103 480.0
HKD2_k127_6760559_1 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007013 443.0
HKD2_k127_6760559_2 MmgE/PrpD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007921 376.0
HKD2_k127_6760559_3 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007038 335.0
HKD2_k127_6760559_4 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 307.0
HKD2_k127_6760559_5 Surface antigen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000179 256.0
HKD2_k127_6760559_6 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000000000000000000001043 194.0
HKD2_k127_6760559_7 Domain of unknown function (DUF4870) K09940 - - 0.00000000000000000000000000000000000008012 145.0
HKD2_k127_6771527_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 6.73e-221 692.0
HKD2_k127_6796568_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 355.0
HKD2_k127_6796568_1 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000615 327.0
HKD2_k127_6796568_2 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533,K15396 - 2.1.1.200 0.00000000000000000000000000000000000000000000000000000000000008595 222.0
HKD2_k127_6819225_0 efflux transmembrane transporter activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 568.0
HKD2_k127_6819225_1 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002182 255.0
HKD2_k127_6824395_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 1.725e-263 824.0
HKD2_k127_6870692_0 COG0493 NADPH-dependent glutamate synthase beta chain and K00266 - 1.4.1.13,1.4.1.14 1.25e-237 745.0
HKD2_k127_6870692_1 glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 289.0
HKD2_k127_6870692_2 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000009003 254.0
HKD2_k127_6877141_0 Sulfatase-modifying factor enzyme 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003264 524.0
HKD2_k127_6877141_1 Splits dipeptides with a prolyl residue in the C- terminal position K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 390.0
HKD2_k127_6877141_2 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030,K10001 - - 0.0000000000000000000000000000000000000000000000000000000000157 217.0
HKD2_k127_6877141_3 RNA recognition motif - - - 0.00000000000000000000000000006383 118.0
HKD2_k127_6877141_4 methyltransferase activity - - - 0.000000000000000000000000003559 118.0
HKD2_k127_6877141_5 protein kinase activity - - - 0.00000000000000000004462 102.0
HKD2_k127_6877141_6 YjbR - - - 0.00000000000000002935 88.0
HKD2_k127_6877141_7 PFAM RNP-1 like RNA-binding protein - - - 0.0000001068 60.0
HKD2_k127_6885124_0 - - - - 4.504e-231 739.0
HKD2_k127_6885124_1 M61 glycyl aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 604.0
HKD2_k127_6885124_10 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 316.0
HKD2_k127_6885124_11 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007171 283.0
HKD2_k127_6885124_12 phospholipase Carboxylesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004617 277.0
HKD2_k127_6885124_13 metallopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000122 247.0
HKD2_k127_6885124_14 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000006665 248.0
HKD2_k127_6885124_15 ATP-binding protein K02013 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000007939 242.0
HKD2_k127_6885124_16 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000003432 243.0
HKD2_k127_6885124_17 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000002645 218.0
HKD2_k127_6885124_18 peptidase - - - 0.000000000000000000000000000000000000000000000000000000006556 220.0
HKD2_k127_6885124_19 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000001663 199.0
HKD2_k127_6885124_2 cytochrome C peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 512.0
HKD2_k127_6885124_20 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000002737 199.0
HKD2_k127_6885124_22 periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000032 188.0
HKD2_k127_6885124_23 LysR substrate binding domain K05817 GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000006041 192.0
HKD2_k127_6885124_24 Phosphoserine phosphatase - - - 0.00000000000000000000000000000000000000000000003767 186.0
HKD2_k127_6885124_25 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000007603 172.0
HKD2_k127_6885124_26 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.00000000000000000000000000000000000000000004289 170.0
HKD2_k127_6885124_27 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.00000000000000000000000000000000000000006314 171.0
HKD2_k127_6885124_28 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000001607 158.0
HKD2_k127_6885124_29 Thioredoxin-like - - - 0.0000000000000000000000000000006303 128.0
HKD2_k127_6885124_3 ABC-type transport system, involved in lipoprotein release, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002326 527.0
HKD2_k127_6885124_30 - - - - 0.00000000000000000000000007456 121.0
HKD2_k127_6885124_32 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000002708 104.0
HKD2_k127_6885124_33 Major Facilitator K02575 GO:0001666,GO:0006950,GO:0008150,GO:0009628,GO:0019222,GO:0031323,GO:0036293,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0062012,GO:0065007,GO:0070482,GO:0090352,GO:1903314 - 0.000000000000000001324 100.0
HKD2_k127_6885124_34 decarboxylase K01607 - 4.1.1.44 0.0000000000000009198 85.0
HKD2_k127_6885124_35 - - - - 0.000000000000002476 87.0
HKD2_k127_6885124_36 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 0.00000000001161 77.0
HKD2_k127_6885124_37 - - - - 0.0000000003858 73.0
HKD2_k127_6885124_38 - - - - 0.00000001187 58.0
HKD2_k127_6885124_39 - - - - 0.000003744 58.0
HKD2_k127_6885124_40 transcription initiation from RNA polymerase II promoter - - - 0.00006142 47.0
HKD2_k127_6885124_5 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006223 463.0
HKD2_k127_6885124_6 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007856 379.0
HKD2_k127_6885124_7 HDOD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 359.0
HKD2_k127_6885124_8 FecCD transport family K02015 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003239 347.0
HKD2_k127_6885124_9 Lipocalin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009387 360.0
HKD2_k127_690810_0 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000001509 220.0
HKD2_k127_690810_1 carboxylic acid catabolic process K01684 - 4.2.1.6 0.000000000000000000000000000000000002865 143.0
HKD2_k127_690810_2 - - - - 0.00001096 50.0
HKD2_k127_6958683_0 DNA helicase - - - 1.673e-307 987.0
HKD2_k127_6958683_1 ATP-dependent helicase K03579 - 3.6.4.13 9.489e-254 808.0
HKD2_k127_6958683_10 TIGRFAM 40-residue YVTN family beta-propeller repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000005612 249.0
HKD2_k127_6958683_11 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000001404 235.0
HKD2_k127_6958683_12 AAA domain, putative AbiEii toxin, Type IV TA system K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000009915 245.0
HKD2_k127_6958683_13 Domain of unknown function (DUF1971) - - - 0.000000000000000000000000000000000000000000000000000000003927 205.0
HKD2_k127_6958683_14 Oxalate decarboxylase - - - 0.0000000000000000000000000000000000000000001009 163.0
HKD2_k127_6958683_15 Transcriptional regulator PadR-like family - - - 0.00000000000000000000000000000000000005287 145.0
HKD2_k127_6958683_16 endonuclease activity - - - 0.0000000000000000000000000000000000001059 147.0
HKD2_k127_6958683_17 MazG-like family - - - 0.0000000000000000000000000000000000002811 149.0
HKD2_k127_6958683_18 metal cluster binding K06940 - - 0.0000000000000000000000000000000000006089 158.0
HKD2_k127_6958683_19 - - - - 0.0000000000000000000000000000004052 134.0
HKD2_k127_6958683_2 LVIVD repeat - - - 4.417e-211 671.0
HKD2_k127_6958683_20 Belongs to the UPF0237 family K07166 - - 0.000000000000000000000000000009146 121.0
HKD2_k127_6958683_21 Protein of unknown function (DUF3175) - - - 0.000000000000000000000000006687 116.0
HKD2_k127_6958683_22 Protein of unknown function (DUF3667) - - - 0.0000000000000000000000000776 118.0
HKD2_k127_6958683_23 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000008875 101.0
HKD2_k127_6958683_24 - - - - 0.00000000000000000004278 98.0
HKD2_k127_6958683_25 - - - - 0.0000000000000000002179 93.0
HKD2_k127_6958683_26 Domain of unknown function (DUF1840) - - - 0.0000000000000000002384 93.0
HKD2_k127_6958683_27 - - - - 0.000000000000000004974 84.0
HKD2_k127_6958683_28 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00000000000000001317 90.0
HKD2_k127_6958683_29 - - - - 0.0000000000000002483 91.0
HKD2_k127_6958683_3 UPF0210 protein K09157 - - 2.371e-210 663.0
HKD2_k127_6958683_30 membrane - - - 0.000000000000003404 80.0
HKD2_k127_6958683_31 - - - - 0.0000000000001566 81.0
HKD2_k127_6958683_34 Glycine zipper 2TM domain - - - 0.0000000002417 68.0
HKD2_k127_6958683_4 RecA-superfamily ATPases implicated in signal transduction K08482 - - 3.287e-201 643.0
HKD2_k127_6958683_5 Bacterial periplasmic substrate-binding proteins K02029,K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002737 567.0
HKD2_k127_6958683_6 Sulfatase K01133 - 3.1.6.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 472.0
HKD2_k127_6958683_7 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008094 453.0
HKD2_k127_6958683_8 histidine kinase A domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 451.0
HKD2_k127_6958683_9 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009978 346.0
HKD2_k127_6982668_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1104.0
HKD2_k127_6982668_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 7.659e-215 673.0
HKD2_k127_6982668_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 336.0
HKD2_k127_6982668_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007214 346.0
HKD2_k127_6982668_4 Capsule assembly protein Wzi - - - 0.000000000000000000000000000000000002144 144.0
HKD2_k127_6982668_5 PFAM AIG2-like - - - 0.00000001338 64.0
HKD2_k127_6990187_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 8.993e-286 894.0
HKD2_k127_6990187_1 Chemotaxis protein histidine kinase and related kinases K02487,K06596 - - 2.979e-268 907.0
HKD2_k127_6990187_10 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001957 368.0
HKD2_k127_6990187_11 Serine hydrolase involved in the detoxification of formaldehyde K01070 - 3.1.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005748 346.0
HKD2_k127_6990187_12 Oxidoreductase FAD-binding domain K02823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 355.0
HKD2_k127_6990187_13 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 340.0
HKD2_k127_6990187_14 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007002 356.0
HKD2_k127_6990187_15 PFAM N-acetylmuramoyl-L-alanine amidase family 2 K03806 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000007364 239.0
HKD2_k127_6990187_16 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000003223 220.0
HKD2_k127_6990187_17 response regulator receiver K02657 - - 0.000000000000000000000000000000000000000000000000000000000000539 217.0
HKD2_k127_6990187_18 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.000000000000000000000000000000000000000000000000000000000003595 213.0
HKD2_k127_6990187_19 - - - - 0.000000000000000000000000000000000000000000000000000000000005461 217.0
HKD2_k127_6990187_2 twitching motility protein K02670 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 526.0
HKD2_k127_6990187_20 adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000008831 219.0
HKD2_k127_6990187_21 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000000000000003778 209.0
HKD2_k127_6990187_22 Pfam:PNPOx_C K00275 - 1.4.3.5 0.000000000000000000000000000000000000000000000000009947 189.0
HKD2_k127_6990187_23 Iron-sulfur cluster insertion protein ErpA K15724 - - 0.00000000000000000000000000000000000000000000000005053 179.0
HKD2_k127_6990187_24 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000007803 171.0
HKD2_k127_6990187_25 cheY-homologous receiver domain K02658 - - 0.000000000000000000000000000000000000000000116 162.0
HKD2_k127_6990187_26 Periplasmic protein TonB links inner and outer membranes K03832 - - 0.00000000000000000000000000000000002477 147.0
HKD2_k127_6990187_27 Two component signalling adaptor domain K02659 - - 0.00000000000000000000000000000000004401 145.0
HKD2_k127_6990187_28 cell shape determination - - - 0.000000000000000000000000000001788 125.0
HKD2_k127_6990187_29 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - 0.000000000000000000000001285 111.0
HKD2_k127_6990187_3 PFAM Type II secretion system protein E K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 506.0
HKD2_k127_6990187_30 - - - - 0.0000000000000000000008934 104.0
HKD2_k127_6990187_31 Two component signalling adaptor domain K06598 - - 0.000000000000000002611 97.0
HKD2_k127_6990187_32 Cysteine-rich CPXCG - - - 0.00000000000001171 79.0
HKD2_k127_6990187_33 - - - - 0.00000009561 53.0
HKD2_k127_6990187_4 Belongs to the GppA Ppx family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004402 495.0
HKD2_k127_6990187_5 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000848 419.0
HKD2_k127_6990187_6 Prephenate dehydrogenase chorismate mutase K00210 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000193 420.0
HKD2_k127_6990187_7 twitching motility protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 419.0
HKD2_k127_6990187_8 chemotaxis protein K02660 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002154 394.0
HKD2_k127_6990187_9 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 377.0
HKD2_k127_7005645_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1150.0
HKD2_k127_7005645_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003486 516.0
HKD2_k127_7005645_2 Type II secretory pathway, component PulF K02653 GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009297,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0032940,GO:0033036,GO:0042886,GO:0043711,GO:0044085,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0098776 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 467.0
HKD2_k127_7005645_3 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 394.0
HKD2_k127_7005645_4 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02464,K02654 - 3.4.23.43 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 325.0
HKD2_k127_7005645_5 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000223 282.0
HKD2_k127_7005645_6 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.000000000000000000000000000000000000000000000000000000000002837 220.0
HKD2_k127_7005645_7 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000001348 186.0
HKD2_k127_7005645_8 Thiamine monophosphate synthase K03574 - 3.6.1.55 0.00000000000000000000000000000006983 134.0
HKD2_k127_7005645_9 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0004132 43.0
HKD2_k127_7086667_0 DNA topological change K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 552.0
HKD2_k127_7086667_1 FAD-NAD(P)-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 436.0
HKD2_k127_7086667_10 protein conserved in cyanobacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000001257 228.0
HKD2_k127_7086667_11 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000004391 167.0
HKD2_k127_7086667_12 PFAM branched-chain amino acid transport - - - 0.0000000000000000000000000000000001244 145.0
HKD2_k127_7086667_13 retrograde transport, endosome to plasma membrane K21440 - - 0.000000000000000000000000000001196 139.0
HKD2_k127_7086667_14 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000005097 132.0
HKD2_k127_7086667_15 transcriptional - - - 0.00000000000000000000000000113 116.0
HKD2_k127_7086667_16 - - - - 0.00000000000000000000001327 106.0
HKD2_k127_7086667_17 Protein of unknown function (DUF2892) - - - 0.00000000000000000003369 91.0
HKD2_k127_7086667_18 carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.0000000000000000001707 103.0
HKD2_k127_7086667_19 - - - - 0.000000000000000001142 98.0
HKD2_k127_7086667_2 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 435.0
HKD2_k127_7086667_20 - - - - 0.000000000000002278 89.0
HKD2_k127_7086667_21 Putative peptidoglycan binding domain - - - 0.0001219 48.0
HKD2_k127_7086667_3 FtsX-like permease family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 439.0
HKD2_k127_7086667_4 long-chain fatty acid transporting porin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 313.0
HKD2_k127_7086667_5 acyl-CoA dehydrogenase K22027 - 1.14.13.235 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002392 293.0
HKD2_k127_7086667_6 branched-chain amino acid permease (azaleucine resistance) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001568 283.0
HKD2_k127_7086667_7 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003968 273.0
HKD2_k127_7086667_8 DSBA oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001823 272.0
HKD2_k127_7086667_9 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000006973 261.0
HKD2_k127_7127468_0 PQQ-like domain K00114 - 1.1.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 462.0
HKD2_k127_7127468_1 PFAM PBS lyase HEAT domain protein - - - 0.0000000000004351 76.0
HKD2_k127_7185919_0 Molecular chaperone. Has ATPase activity K04079 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 - 8.212e-237 747.0
HKD2_k127_7185919_1 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 593.0
HKD2_k127_7185919_10 - - - - 0.0000000000000000000000000009244 124.0
HKD2_k127_7185919_11 RES - - - 0.000000000000000000000000003666 122.0
HKD2_k127_7185919_12 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell - - - 0.0000000000000000000001092 98.0
HKD2_k127_7185919_13 protein conserved in bacteria - - - 0.0000000000000000000006078 100.0
HKD2_k127_7185919_14 Protein of unknown function (DUF2384) - - - 0.0000000000000000002048 93.0
HKD2_k127_7185919_15 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - 0.000000000000000005576 85.0
HKD2_k127_7185919_16 SnoaL-like polyketide cyclase K06893 - - 0.0000001167 61.0
HKD2_k127_7185919_2 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007645 379.0
HKD2_k127_7185919_3 involved in chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001581 254.0
HKD2_k127_7185919_4 Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) K02517,K12974 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009245,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046467,GO:0046493,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.241,2.3.1.242 0.000000000000000000000000000000000000000000000000000000000000323 233.0
HKD2_k127_7185919_5 Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) K02517,K12974 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009245,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046467,GO:0046493,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.241,2.3.1.242 0.0000000000000000000000000000000000000000000000000000000002017 216.0
HKD2_k127_7185919_6 Serine aminopeptidase, S33 K07018 - - 0.0000000000000000000000000000000000000000000000005455 182.0
HKD2_k127_7185919_7 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000001403 170.0
HKD2_k127_7185919_8 integral membrane protein K02221 - - 0.000000000000000000000000000000001765 136.0
HKD2_k127_7185919_9 Domain of unknown function (DUF4426) - - - 0.0000000000000000000000000003706 121.0
HKD2_k127_7215810_0 Nitric oxide reductase large subunit K04561 - 1.7.2.5 0.0 1172.0
HKD2_k127_7215810_1 ABC transporter transmembrane region K06147,K11085 - - 5.62e-204 651.0
HKD2_k127_7215810_10 - - - - 0.0000000000000000000000005567 117.0
HKD2_k127_7215810_11 - - - - 0.0000000000000000000001084 108.0
HKD2_k127_7215810_12 glycosyl transferase group 1 K14335 - - 0.00000000000001752 76.0
HKD2_k127_7215810_13 SnoaL-like domain - - - 0.000000001165 68.0
HKD2_k127_7215810_14 Belongs to the 'phage' integrase family - - - 0.00000004132 61.0
HKD2_k127_7215810_2 metallo-beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 418.0
HKD2_k127_7215810_3 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000005869 255.0
HKD2_k127_7215810_4 Belongs to the MIP aquaporin (TC 1.A.8) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000004335 241.0
HKD2_k127_7215810_5 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000005742 216.0
HKD2_k127_7215810_6 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000000000000000000000000000000000000000000000000007668 196.0
HKD2_k127_7215810_7 RNA recognition motif - - - 0.00000000000000000000000000000004313 126.0
HKD2_k127_7215810_8 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.00000000000000000000000000000006275 128.0
HKD2_k127_7322268_0 FtsX-like permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002607 618.0
HKD2_k127_7322268_1 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 310.0
HKD2_k127_7322268_2 Drug exporters of the RND superfamily - - - 0.00000000000000000000000000000000000000000000000001031 195.0
HKD2_k127_7322268_3 Ankyrin repeats (many copies) - - - 0.0000000004342 72.0
HKD2_k127_7322268_4 Helix-turn-helix domain - - - 0.00001574 54.0
HKD2_k127_750531_0 ABC transporter K06147,K18893 - - 2.954e-242 766.0
HKD2_k127_750531_1 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 380.0
HKD2_k127_750531_2 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000511 391.0
HKD2_k127_750531_3 FMN-dependent dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007948 323.0
HKD2_k127_750531_4 Thioesterase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000057 311.0
HKD2_k127_750531_5 Domain of Unknown Function (DUF1259) - - - 0.00000000000000000000000000000000000000000000000000000000005673 208.0
HKD2_k127_750531_7 Phosphopantetheine attachment site - - - 0.00000000004746 66.0
HKD2_k127_7538622_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18299 - - 0.0 1428.0
HKD2_k127_7538622_1 M13 family peptidase K01415,K07386 - 3.4.24.71 7.043e-213 684.0
HKD2_k127_7538622_10 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000003596 192.0
HKD2_k127_7538622_11 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000000000000000000000005912 185.0
HKD2_k127_7538622_12 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000001334 177.0
HKD2_k127_7538622_13 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000007747 160.0
HKD2_k127_7538622_14 SnoaL-like domain - - - 0.0000000000000000000000000000000000002014 148.0
HKD2_k127_7538622_15 Flavodoxin-like fold - - - 0.00000000000000000000000000000000004394 141.0
HKD2_k127_7538622_16 YCII-related domain - - - 0.000000000000000000000000000000001306 146.0
HKD2_k127_7538622_17 amine dehydrogenase activity K12287 - - 0.00000000000004838 84.0
HKD2_k127_7538622_18 - - - - 0.000000000009779 76.0
HKD2_k127_7538622_19 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000437 71.0
HKD2_k127_7538622_2 ABC-2 type transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 392.0
HKD2_k127_7538622_20 decarboxylase K01607 - 4.1.1.44 0.00000000004813 74.0
HKD2_k127_7538622_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K18298,K19586 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 382.0
HKD2_k127_7538622_4 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 358.0
HKD2_k127_7538622_5 Oxidoreductase family, NAD-binding Rossmann fold K10219 - 1.1.1.312 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004703 295.0
HKD2_k127_7538622_6 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004546 282.0
HKD2_k127_7538622_7 protein-(glutamine-N5) methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001303 280.0
HKD2_k127_7538622_8 Uncharacterized protein conserved in bacteria (DUF2219) - - - 0.0000000000000000000000000000000000000000000000000000000001202 223.0
HKD2_k127_7538622_9 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000004483 220.0
HKD2_k127_7653822_0 Major Facilitator Superfamily - - - 2.121e-254 796.0
HKD2_k127_7653822_1 Beta-ketoacyl synthase, C-terminal domain K09458,K14660 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003872 413.0
HKD2_k127_7653822_2 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 398.0
HKD2_k127_7653822_3 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006011 351.0
HKD2_k127_7653822_4 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000001982 257.0
HKD2_k127_7653822_5 o-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000003306 209.0
HKD2_k127_7653822_6 Haem-degrading - - - 0.00000000000000000000000000000000000005533 150.0
HKD2_k127_7653822_7 Phosphopantetheine attachment site K02078 - - 0.000000000001138 70.0
HKD2_k127_7666201_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1238.0
HKD2_k127_7666201_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses K01916,K01950 - 6.3.1.5,6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003111 618.0
HKD2_k127_7666201_2 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 362.0
HKD2_k127_7666201_3 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006541 272.0
HKD2_k127_7666201_4 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000000000000000000000000000002533 206.0
HKD2_k127_7666201_5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.0000000000000000000000000000000001314 134.0
HKD2_k127_7670847_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009194 254.0
HKD2_k127_7670847_1 Transmembrane secretion effector - - - 0.000000000000000002354 89.0
HKD2_k127_767657_0 Bacterial protein of unknown function (DUF853) K06915 - - 2.709e-208 658.0
HKD2_k127_767657_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000001787 215.0
HKD2_k127_767657_2 DUF218 domain - - - 0.00000000000000000000000000000000000000000000003871 178.0
HKD2_k127_767657_3 - - - - 0.00000000000000000000000000000000003913 141.0
HKD2_k127_767657_4 SnoaL-like domain - - - 0.000000000008122 72.0
HKD2_k127_767657_5 Calcium and calcium calmodulin-dependent serine threonine-protein K08794,K13412 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004683,GO:0005488,GO:0005515,GO:0005516,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009608,GO:0009877,GO:0009931,GO:0009987,GO:0010857,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0023052,GO:0035556,GO:0036211,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.11.1,2.7.11.17 0.0003978 48.0
HKD2_k127_7678423_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 1.209e-281 882.0
HKD2_k127_7678423_1 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002902 610.0
HKD2_k127_7678423_10 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 299.0
HKD2_k127_7678423_11 Trypsin K04691 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004234 288.0
HKD2_k127_7678423_12 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001037 284.0
HKD2_k127_7678423_13 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271,K12961 - 5.3.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000005454 265.0
HKD2_k127_7678423_14 Stringent starvation protein A K03599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008164 260.0
HKD2_k127_7678423_15 Cytochrome C1 family K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002028 273.0
HKD2_k127_7678423_16 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000006296 247.0
HKD2_k127_7678423_17 PFAM LppC K07121 - - 0.000000000000000000000000000000000000000000000000000000000000000000126 255.0
HKD2_k127_7678423_18 COG1544 Ribosome-associated protein Y (PSrp-1) K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000001777 140.0
HKD2_k127_7678423_19 Stringent starvation protein B K03600 GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904 - 0.0000000000000000000000000000000000694 145.0
HKD2_k127_7678423_2 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008496 601.0
HKD2_k127_7678423_20 - - - - 0.00000000000000000000000005787 111.0
HKD2_k127_7678423_21 Belongs to the BolA IbaG family - - - 0.00000000000000000005836 94.0
HKD2_k127_7678423_22 Belongs to the UPF0102 family K07460 - - 0.000000000000000009751 98.0
HKD2_k127_7678423_23 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA K11719 - - 0.00000000000000002618 90.0
HKD2_k127_7678423_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003693 536.0
HKD2_k127_7678423_4 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 526.0
HKD2_k127_7678423_5 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 501.0
HKD2_k127_7678423_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003422 428.0
HKD2_k127_7678423_7 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 387.0
HKD2_k127_7678423_8 Domain of unknown function (DUF4147) K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 361.0
HKD2_k127_7678423_9 ABC transporter ATP-binding protein K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 338.0
HKD2_k127_7693080_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1184.0
HKD2_k127_7693080_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1e-323 1002.0
HKD2_k127_7693080_10 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 463.0
HKD2_k127_7693080_11 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000666 431.0
HKD2_k127_7693080_12 Prephenate dehydratase K14170 - 4.2.1.51,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 424.0
HKD2_k127_7693080_13 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007209 421.0
HKD2_k127_7693080_14 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia K01426 - 3.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005566 418.0
HKD2_k127_7693080_15 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 404.0
HKD2_k127_7693080_16 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007849 405.0
HKD2_k127_7693080_17 DNA recombination protein RmuC K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 403.0
HKD2_k127_7693080_18 Psort location Cytoplasmic, score 8.96 K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004869 372.0
HKD2_k127_7693080_19 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 366.0
HKD2_k127_7693080_2 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 1.574e-319 991.0
HKD2_k127_7693080_20 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 331.0
HKD2_k127_7693080_21 methyltransferase K10218 GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0042537,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 4.1.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001801 317.0
HKD2_k127_7693080_22 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 299.0
HKD2_k127_7693080_23 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 292.0
HKD2_k127_7693080_24 Belongs to the SUA5 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001143 276.0
HKD2_k127_7693080_25 PFAM Helix-turn-helix, type 11 domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001239 282.0
HKD2_k127_7693080_26 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006749 282.0
HKD2_k127_7693080_27 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000349 273.0
HKD2_k127_7693080_28 short-chain dehydrogenase reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007561 268.0
HKD2_k127_7693080_29 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000003383 254.0
HKD2_k127_7693080_3 Required for chromosome condensation and partitioning K03529 - - 4.666e-312 994.0
HKD2_k127_7693080_30 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000001412 252.0
HKD2_k127_7693080_31 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.00000000000000000000000000000000000000000000000000000000000000000001439 242.0
HKD2_k127_7693080_32 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008653,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1903509 - 0.00000000000000000000000000000000000000000000000000000000000000000008406 247.0
HKD2_k127_7693080_33 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000000001998 233.0
HKD2_k127_7693080_34 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000002508 238.0
HKD2_k127_7693080_35 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000002127 224.0
HKD2_k127_7693080_36 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.00000000000000000000000000000000000000000000000000000000000001418 218.0
HKD2_k127_7693080_37 Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000001803 223.0
HKD2_k127_7693080_38 NmrA-like family K19267 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000008576 217.0
HKD2_k127_7693080_39 HAD-superfamily hydrolase, subfamily IA, variant 1 K22292 - 3.1.3.105 0.00000000000000000000000000000000000000000000000000008703 195.0
HKD2_k127_7693080_4 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 1.611e-271 845.0
HKD2_k127_7693080_40 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression K06204 - - 0.0000000000000000000000000000000000000000000000000001229 195.0
HKD2_k127_7693080_41 sister chromatid segregation - - - 0.0000000000000000000000000000000000000000000000002019 186.0
HKD2_k127_7693080_42 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000000000000000008017 176.0
HKD2_k127_7693080_43 probably involved in intracellular septation K06190 - - 0.000000000000000000000000000000000000000000000008076 183.0
HKD2_k127_7693080_44 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.000000000000000000000000000000000000000003372 157.0
HKD2_k127_7693080_45 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000000000000000001137 162.0
HKD2_k127_7693080_46 Ion channel - - - 0.000000000000000000000000000000000001905 145.0
HKD2_k127_7693080_47 sister chromatid segregation - - - 0.00000000000000000000000000000000000757 147.0
HKD2_k127_7693080_48 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000000000000003189 133.0
HKD2_k127_7693080_49 Belongs to the BolA IbaG family K05527 - - 0.0000000000000000000000000000000004805 133.0
HKD2_k127_7693080_5 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 2.049e-265 837.0
HKD2_k127_7693080_50 Domain of unknown function (DUF4157) - - - 0.000000000000000000000000000000004502 135.0
HKD2_k127_7693080_51 PFAM RNA recognition motif - - - 0.00000000000000000000000000000001255 131.0
HKD2_k127_7693080_52 protein import - - - 0.000000000000000000000000004887 123.0
HKD2_k127_7693080_53 - - - - 0.000000000000000000000000005622 120.0
HKD2_k127_7693080_54 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000002686 94.0
HKD2_k127_7693080_55 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000000000005096 81.0
HKD2_k127_7693080_56 TIGRFAM competence protein ComEA helix-hairpin-helix K02237 - - 0.00000000000001563 77.0
HKD2_k127_7693080_57 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins K03528 GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - 0.00000000006247 71.0
HKD2_k127_7693080_58 SnoaL-like domain - - - 0.000002243 56.0
HKD2_k127_7693080_6 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002629 508.0
HKD2_k127_7693080_7 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007952 497.0
HKD2_k127_7693080_8 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00210,K00220,K00800 - 1.3.1.12,1.3.1.43,2.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006504 473.0
HKD2_k127_7693080_9 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004882 481.0
HKD2_k127_7710887_1 Cytochrome C biogenesis protein transmembrane region - - - 2.491e-243 772.0
HKD2_k127_7710887_10 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000033 276.0
HKD2_k127_7710887_11 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002863 274.0
HKD2_k127_7710887_12 IclR helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002598 248.0
HKD2_k127_7710887_13 hopanoid biosynthesis associated protein HpnK K03478 - 3.5.1.105 0.00000000000000000000000000000000000000000000000000000000000000000008031 258.0
HKD2_k127_7710887_14 SelR domain K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000003566 227.0
HKD2_k127_7710887_15 Ribosomal protein L11 methyltransferase (PrmA) - - - 0.000000000000000000000000000000000000000000000000000000000000008484 222.0
HKD2_k127_7710887_16 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - 0.0000000000000000000000000000000000000000000000000000000001144 211.0
HKD2_k127_7710887_17 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.00000000000000000000000000000000000000000002998 177.0
HKD2_k127_7710887_18 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000009036 143.0
HKD2_k127_7710887_19 - - - - 0.0000000000000000000000001765 109.0
HKD2_k127_7710887_2 belongs to the aldehyde dehydrogenase family K00146 - 1.2.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006928 574.0
HKD2_k127_7710887_20 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000338 120.0
HKD2_k127_7710887_21 Domain of unknown function (DUF4136) - - - 0.00000000002526 72.0
HKD2_k127_7710887_22 Predicted membrane protein (DUF2231) - - - 0.000000001336 68.0
HKD2_k127_7710887_23 PFAM GtrA-like protein - - - 0.00000001135 62.0
HKD2_k127_7710887_3 belongs to the aldehyde dehydrogenase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000928 511.0
HKD2_k127_7710887_4 Voltage gated chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000043 467.0
HKD2_k127_7710887_5 SMP-30/Gluconolaconase/LRE-like region K01053,K13735 - 3.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005466 437.0
HKD2_k127_7710887_6 PFAM peptidase S1 and S6, chymotrypsin Hap K08070 - 1.3.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005759 403.0
HKD2_k127_7710887_7 PFAM Glycosyl transferase family 2 K20534 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004445 374.0
HKD2_k127_7710887_8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002377 295.0
HKD2_k127_7710887_9 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004611 284.0
HKD2_k127_7712781_0 Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02401 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 310.0
HKD2_k127_7712781_1 Plays a role in the flagellum-specific transport system K02419 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009024 288.0
HKD2_k127_7712781_2 Role in flagellar biosynthesis K02421 - - 0.000000000000000000000000000000000000000000000000000000000000006205 225.0
HKD2_k127_7712781_3 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02416 - - 0.0000000000000000000000000000000000000000000000000004143 202.0
HKD2_k127_7712781_4 FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02417 - - 0.0000000000000000000000000000000001312 135.0
HKD2_k127_7712781_5 Role in flagellar biosynthesis K02420 - - 0.00000000000000000000000000558 112.0
HKD2_k127_7712781_6 Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin K02400 - - 0.000000000000000000002359 95.0
HKD2_k127_7712781_7 Flagellar basal body-associated protein FliL - - - 0.000000000000000000005832 100.0
HKD2_k127_7712781_8 Flagellar hook-length control protein FliK K02414 - - 0.000000000005642 70.0
HKD2_k127_7712781_9 Flagellar biosynthesis protein, FliO K02418 - - 0.00006736 54.0
HKD2_k127_7725109_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 1.03e-318 993.0
HKD2_k127_7725109_1 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K07303 - 1.3.99.16 1.627e-234 756.0
HKD2_k127_7725109_10 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000002617 140.0
HKD2_k127_7725109_11 Immunoglobulin-like domain of bacterial spore germination - - - 0.00000000000000000000000001131 118.0
HKD2_k127_7725109_12 - - - - 0.00000000000000001889 81.0
HKD2_k127_7725109_13 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000002569 85.0
HKD2_k127_7725109_14 long-chain fatty acid transport protein - - - 0.00000004666 56.0
HKD2_k127_7725109_2 TonB dependent receptor - - - 2.507e-205 674.0
HKD2_k127_7725109_3 TonB dependent receptor - - - 2.604e-194 642.0
HKD2_k127_7725109_4 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003325 245.0
HKD2_k127_7725109_5 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000001488 229.0
HKD2_k127_7725109_6 [2Fe-2S] binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000009263 218.0
HKD2_k127_7725109_7 universal stress protein K14055 - - 0.00000000000000000000000000000000000000000000000007841 189.0
HKD2_k127_7725109_8 Flavodoxin - - - 0.0000000000000000000000000000000000000002165 154.0
HKD2_k127_7725109_9 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000003613 142.0
HKD2_k127_7728713_0 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000001347 236.0
HKD2_k127_7728713_1 aldo-keto reductase (NADP) activity K05275 - 1.1.1.65 0.0000000000000000000000000000000001925 134.0
HKD2_k127_7728713_2 positive regulation of macromolecule biosynthetic process K03973 - - 0.0000000000001053 79.0
HKD2_k127_7749849_0 Peptidase dimerisation domain K13049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 533.0
HKD2_k127_7749849_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 521.0
HKD2_k127_7749849_10 transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000004057 258.0
HKD2_k127_7749849_11 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002016 249.0
HKD2_k127_7749849_12 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000000000001624 230.0
HKD2_k127_7749849_13 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 - 3.1.3.45 0.0000000000000000000000000000000000000000000000000000000003227 211.0
HKD2_k127_7749849_14 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0000000000000000000000000000000000000000000000001898 181.0
HKD2_k127_7749849_15 Thiol disulfide interchange protein K03673 - - 0.000000000000000000000000000000000000000000002108 179.0
HKD2_k127_7749849_16 S1/P1 Nuclease - - - 0.000000000000000000000000000000000000000006207 172.0
HKD2_k127_7749849_17 S1 P1 nuclease - - - 0.000000000000000000000000000000003433 144.0
HKD2_k127_7749849_18 Phage shock protein A K03615,K03969,K09749,K21471 - - 0.0000000000000000000000000000004112 129.0
HKD2_k127_7749849_19 - - - - 0.00000000000000000000000000004126 125.0
HKD2_k127_7749849_2 Transaldolase/Fructose-6-phosphate aldolase K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000968 431.0
HKD2_k127_7749849_20 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000007792 68.0
HKD2_k127_7749849_3 Belongs to the KdsA family K01627 - 2.5.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 427.0
HKD2_k127_7749849_4 von Willebrand factor, type A K11912 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007606 411.0
HKD2_k127_7749849_5 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006526 400.0
HKD2_k127_7749849_6 response regulator K07776 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 319.0
HKD2_k127_7749849_7 Putative ABC exporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002161 334.0
HKD2_k127_7749849_8 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008434 279.0
HKD2_k127_7749849_9 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000006957 266.0
HKD2_k127_7757269_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1146.0
HKD2_k127_7757269_1 Glucoamylase and related glycosyl hydrolases - - - 6.057e-209 676.0
HKD2_k127_7757269_10 Transcriptional regulator K03566 - - 0.0000000000000000000000000000000000000000000000000000000000000004989 239.0
HKD2_k127_7757269_11 Belongs to the BI1 family K06890,K19416 - - 0.00000000000000000000000000000000000000000000000000000000006166 212.0
HKD2_k127_7757269_12 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000002434 202.0
HKD2_k127_7757269_13 THUMP - - - 0.00000000000000000000000000000000000000000000000006773 184.0
HKD2_k127_7757269_14 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000005258 184.0
HKD2_k127_7757269_15 Belongs to the CinA family K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000378 178.0
HKD2_k127_7757269_16 Regulatory protein recX K03565 GO:0003674,GO:0005488,GO:0005515,GO:0006282,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0071496,GO:0080090,GO:0080134,GO:0080135,GO:0098772,GO:2001020 - 0.000000000000000000000000000000001447 139.0
HKD2_k127_7757269_17 YCII-related domain - - - 0.000000000000000000000000000000001696 135.0
HKD2_k127_7757269_18 - - - - 0.000000000000000000000000000009838 126.0
HKD2_k127_7757269_19 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000001367 123.0
HKD2_k127_7757269_2 DNA polymerase X family K02347 - - 2.002e-204 656.0
HKD2_k127_7757269_20 peroxiredoxin activity K03564,K07638 - 1.11.1.15,2.7.13.3 0.000000000000000000000000005922 122.0
HKD2_k127_7757269_21 - - - - 0.000000000000000000000000007672 120.0
HKD2_k127_7757269_22 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000034 114.0
HKD2_k127_7757269_23 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding K03563 - - 0.000000000000000000001028 98.0
HKD2_k127_7757269_24 GtrA-like protein - - - 0.00000000000508 75.0
HKD2_k127_7757269_25 GDSL-like Lipase/Acylhydrolase - - - 0.00000000001455 76.0
HKD2_k127_7757269_26 COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - 0.00000007512 55.0
HKD2_k127_7757269_27 BON domain - - - 0.00001362 51.0
HKD2_k127_7757269_3 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006744 557.0
HKD2_k127_7757269_4 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003309 439.0
HKD2_k127_7757269_5 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360 6.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003341 367.0
HKD2_k127_7757269_6 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000654 311.0
HKD2_k127_7757269_7 Mut7-C RNAse domain K09122 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 294.0
HKD2_k127_7757269_8 Dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 292.0
HKD2_k127_7757269_9 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001153 254.0
HKD2_k127_7772600_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - 3.035e-197 624.0
HKD2_k127_7772600_1 PFAM aldehyde oxidase and xanthine dehydrogenase a b hammerhead - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004418 520.0
HKD2_k127_7772600_10 protein conserved in bacteria K01814 - 5.3.1.16 0.0000000000000000000000000000000004188 146.0
HKD2_k127_7772600_11 enzyme of heme biosynthesis K02496,K13543 - 2.1.1.107,4.2.1.75 0.0000000001028 68.0
HKD2_k127_7772600_12 Isoprenylcysteine carboxyl methyltransferase - - - 0.0000258 54.0
HKD2_k127_7772600_2 Belongs to the 'phage' integrase family. XerC subfamily K03733 GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002462 336.0
HKD2_k127_7772600_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005049 285.0
HKD2_k127_7772600_4 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000001931 256.0
HKD2_k127_7772600_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000005493 239.0
HKD2_k127_7772600_6 involved in chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000001799 234.0
HKD2_k127_7772600_7 enzyme of heme biosynthesis K02498 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000004774 212.0
HKD2_k127_7772600_8 [2Fe-2S] binding domain K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000001786 198.0
HKD2_k127_7772600_9 Protein of unknown function, DUF484 K09921 - - 0.0000000000000000000000000000000000912 147.0
HKD2_k127_7784935_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001456 467.0
HKD2_k127_7784935_1 Ribosomal protein L17 K02879 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000007174 184.0
HKD2_k127_7784935_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.0000000000000000000000000001485 115.0
HKD2_k127_7798380_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0 1047.0
HKD2_k127_7798380_1 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 1.645e-299 960.0
HKD2_k127_7798380_10 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 403.0
HKD2_k127_7798380_11 PepSY-associated TM region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008893 309.0
HKD2_k127_7798380_12 FAD linked K11472 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000854 282.0
HKD2_k127_7798380_13 TIGRFAM YihY family protein (not ribonuclease BN) K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001549 268.0
HKD2_k127_7798380_14 Belongs to the MtfA family K09933 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002119 263.0
HKD2_k127_7798380_15 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001392 253.0
HKD2_k127_7798380_16 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005583 250.0
HKD2_k127_7798380_17 4Fe-4S dicluster domain K11473 GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 - 0.0000000000000000000000000000000000000000000000000000000000000000003198 239.0
HKD2_k127_7798380_18 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.000000000000000000000000000000000000000000000000000000000000000000509 237.0
HKD2_k127_7798380_19 Prolyl 4-hydroxylase alpha subunit homologues. K00472 - 1.14.11.2 0.0000000000000000000000000000000000000000000000000000000000000006135 234.0
HKD2_k127_7798380_2 Glycosyl hydrolases family 15 - - - 2.485e-285 892.0
HKD2_k127_7798380_20 Domain of Unknown Function (DUF748) - - - 0.00000000000000000000000000000000000000000000000000000000000008233 228.0
HKD2_k127_7798380_21 Water Stress and Hypersensitive response - - - 0.0000000000000000000000000000000000000000000000002081 183.0
HKD2_k127_7798380_22 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000003456 165.0
HKD2_k127_7798380_23 Protein of unknown function (DUF2721) - - - 0.000000000000000000000000000000001119 138.0
HKD2_k127_7798380_24 - - - - 0.000000000000000000000000000000002341 136.0
HKD2_k127_7798380_25 Putative phage abortive infection protein - - - 0.00000000000000000000000000000000881 139.0
HKD2_k127_7798380_26 Domain of unknown function (DUF4142) K08995 - - 0.000000000000000000002069 105.0
HKD2_k127_7798380_27 (twin-arginine translocation) pathway signal - - - 0.0000000000000000001111 96.0
HKD2_k127_7798380_28 Protein of unknown function (DUF1328) - - - 0.000000000001237 73.0
HKD2_k127_7798380_29 YfaZ precursor - - - 0.0000000001367 71.0
HKD2_k127_7798380_3 ATP dependent DNA ligase C terminal region K01971 - 6.5.1.1 3.763e-229 737.0
HKD2_k127_7798380_30 PFAM Prokaryotic metallothionein K21904 - - 0.00008172 47.0
HKD2_k127_7798380_31 PFAM PRC-barrel domain - - - 0.0001027 53.0
HKD2_k127_7798380_32 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008878,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0070566,GO:0071704,GO:1901576 2.7.7.27 0.0004861 48.0
HKD2_k127_7798380_4 FAD linked oxidases, C-terminal domain K00102,K00104 - 1.1.2.4,1.1.3.15 1.505e-222 701.0
HKD2_k127_7798380_5 Alpha amylase, catalytic domain K01236 - 3.2.1.141 2.209e-194 635.0
HKD2_k127_7798380_6 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004294 630.0
HKD2_k127_7798380_7 PLD-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 490.0
HKD2_k127_7798380_8 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 430.0
HKD2_k127_7798380_9 Transaldolase/Fructose-6-phosphate aldolase K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 424.0
HKD2_k127_7812722_0 Involved in the TonB-independent uptake of proteins K03641 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006035 432.0
HKD2_k127_7812722_1 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 317.0
HKD2_k127_7812722_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 318.0
HKD2_k127_7812722_3 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000007177 173.0
HKD2_k127_7812722_4 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000002358 164.0
HKD2_k127_7812722_5 TonB C terminal K03646 - - 0.0000000000001275 76.0
HKD2_k127_7819597_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 7.791e-279 865.0
HKD2_k127_7819597_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 1.213e-254 803.0
HKD2_k127_7819597_10 cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009495 336.0
HKD2_k127_7819597_11 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005527 320.0
HKD2_k127_7819597_12 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 314.0
HKD2_k127_7819597_13 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000000000000001479 231.0
HKD2_k127_7819597_14 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000001026 231.0
HKD2_k127_7819597_15 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000001258 220.0
HKD2_k127_7819597_16 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000000000000000003691 212.0
HKD2_k127_7819597_17 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000003071 198.0
HKD2_k127_7819597_18 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000000002416 176.0
HKD2_k127_7819597_19 COG3175 Cytochrome oxidase assembly factor K02258 - - 0.000000000000000000000000000000000000000000000003893 180.0
HKD2_k127_7819597_2 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 1.768e-235 751.0
HKD2_k127_7819597_20 Competence protein - - - 0.00000000000000000000000000000000349 136.0
HKD2_k127_7819597_21 mRNA catabolic process - - - 0.00000000000000000000000000000001155 136.0
HKD2_k127_7819597_22 SURF1-like protein - - - 0.00000000000000000000000000000003184 135.0
HKD2_k127_7819597_23 50S ribosomal protein L31 K02909 - - 0.00000000000000000000000000000144 126.0
HKD2_k127_7819597_24 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000000000000197 106.0
HKD2_k127_7819597_25 Protein of unknown function (DUF2909) - - - 0.0002447 49.0
HKD2_k127_7819597_26 signal sequence binding - - - 0.0004867 52.0
HKD2_k127_7819597_3 penicillin-binding protein K05366 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 2.172e-209 678.0
HKD2_k127_7819597_4 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 603.0
HKD2_k127_7819597_5 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 471.0
HKD2_k127_7819597_6 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000627 470.0
HKD2_k127_7819597_7 Heme copper-type cytochrome quinol oxidase subunit 3 K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005628 389.0
HKD2_k127_7819597_8 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004661 360.0
HKD2_k127_7819597_9 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002825 349.0
HKD2_k127_7825416_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 6.645e-197 622.0
HKD2_k127_7825416_1 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000874 424.0
HKD2_k127_7825416_10 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.0000000000000000000000000000000000000000000000000000000000005708 213.0
HKD2_k127_7825416_11 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000003151 208.0
HKD2_k127_7825416_12 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000001027 180.0
HKD2_k127_7825416_13 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000001659 169.0
HKD2_k127_7825416_14 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000006639 161.0
HKD2_k127_7825416_15 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000000000000001687 157.0
HKD2_k127_7825416_16 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000006141 157.0
HKD2_k127_7825416_17 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000001723 147.0
HKD2_k127_7825416_18 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000281 149.0
HKD2_k127_7825416_19 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.00000000000000000000000000000006616 135.0
HKD2_k127_7825416_2 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003491 314.0
HKD2_k127_7825416_20 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000002949 114.0
HKD2_k127_7825416_21 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.000000000000000000000002693 113.0
HKD2_k127_7825416_22 Ribosomal protein L30 K02907 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000009534 83.0
HKD2_k127_7825416_23 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000003767 68.0
HKD2_k127_7825416_24 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.00000000498 65.0
HKD2_k127_7825416_3 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005992 295.0
HKD2_k127_7825416_4 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001338 285.0
HKD2_k127_7825416_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001302 250.0
HKD2_k127_7825416_6 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000002347 248.0
HKD2_k127_7825416_7 Forms part of the polypeptide exit tunnel K02926 - - 0.0000000000000000000000000000000000000000000000000000000000000000001555 244.0
HKD2_k127_7825416_8 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.000000000000000000000000000000000000000000000000000000000000000011 228.0
HKD2_k127_7825416_9 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000000000000000000000001269 226.0
HKD2_k127_7880783_0 COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits K04090 - 1.2.7.8 0.0 1349.0
HKD2_k127_7880783_1 Tetratricopeptide repeat - - - 3.284e-225 733.0
HKD2_k127_7880783_10 long-chain fatty acid transporting porin activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000001026 250.0
HKD2_k127_7880783_11 - - - - 0.00000000000000000000000000000000000000000000000000000001893 203.0
HKD2_k127_7880783_12 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.0000000000000000000000000000000000000000000000000002302 198.0
HKD2_k127_7880783_13 nitrogen regulatory protein P-II K04751,K04752 - - 0.0000000000000000000000000000000000000000000000007447 177.0
HKD2_k127_7880783_14 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 0.000000000000000000000000000000000000000000002191 167.0
HKD2_k127_7880783_15 TPR repeat - - - 0.0000000000000000000000000000000000002376 152.0
HKD2_k127_7880783_16 Thioredoxin-like - - - 0.0000000000000000000000000000000009795 136.0
HKD2_k127_7880783_17 Biopolymer transport protein ExbD/TolR - - - 0.00000000000000000000000000000001392 134.0
HKD2_k127_7880783_18 Biopolymer transport protein ExbD/TolR - - - 0.000000000000000000000000000006176 125.0
HKD2_k127_7880783_2 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 - 6.3.5.3 5.03e-219 694.0
HKD2_k127_7880783_20 DnaK suppressor protein - - - 0.000000000000001236 85.0
HKD2_k127_7880783_21 - - - - 0.0000000000002345 81.0
HKD2_k127_7880783_3 Ammonium Transporter K03320 - - 4.532e-199 630.0
HKD2_k127_7880783_4 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006076 440.0
HKD2_k127_7880783_5 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 312.0
HKD2_k127_7880783_6 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 301.0
HKD2_k127_7880783_7 ATPase activity K02013,K05776 - 3.6.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 303.0
HKD2_k127_7880783_8 PFAM MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006407 258.0
HKD2_k127_7880783_9 Inositol monophosphatase family K01092,K18649 - 3.1.3.15,3.1.3.25,3.1.3.93 0.000000000000000000000000000000000000000000000000000000000000000000000001866 253.0
HKD2_k127_7902351_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0 1162.0
HKD2_k127_7902351_1 Adenylate cyclase - - - 2.014e-237 752.0
HKD2_k127_7902351_10 Cytochrome bd terminal oxidase subunit II K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 387.0
HKD2_k127_7902351_11 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003135 379.0
HKD2_k127_7902351_12 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 352.0
HKD2_k127_7902351_13 Tetratricopeptide repeats K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 352.0
HKD2_k127_7902351_14 ErfK YbiS YcfS YnhG family protein K16291 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002813 323.0
HKD2_k127_7902351_15 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 319.0
HKD2_k127_7902351_16 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002376 311.0
HKD2_k127_7902351_17 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 301.0
HKD2_k127_7902351_18 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003469 295.0
HKD2_k127_7902351_19 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008690,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0046401,GO:0046872,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001182 280.0
HKD2_k127_7902351_2 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 2.628e-213 694.0
HKD2_k127_7902351_20 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000004988 265.0
HKD2_k127_7902351_21 MotA TolQ ExbB proton channel family K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000001906 242.0
HKD2_k127_7902351_22 PFAM Patatin K07001 - - 0.0000000000000000000000000000000000000000000000000000000000002321 230.0
HKD2_k127_7902351_23 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000001157 199.0
HKD2_k127_7902351_24 low molecular weight K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000002443 190.0
HKD2_k127_7902351_25 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division K14160 - - 0.000000000000000000000000000000000000000000000146 177.0
HKD2_k127_7902351_26 Bacterial-like globin K06886 - - 0.0000000000000000000000000000000000000000014 161.0
HKD2_k127_7902351_27 - - - - 0.00000000000000000000000000000001195 132.0
HKD2_k127_7902351_28 Biopolymer transport protein ExbD/TolR K03559 - - 0.000000000000000000000000000000501 127.0
HKD2_k127_7902351_29 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000000000001334 100.0
HKD2_k127_7902351_3 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004285 582.0
HKD2_k127_7902351_30 metal-binding, possibly nucleic acid-binding protein K07040 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000001892 93.0
HKD2_k127_7902351_31 Winged helix DNA-binding domain - - - 0.0000000000000002752 85.0
HKD2_k127_7902351_32 - - - - 0.000000000000000434 81.0
HKD2_k127_7902351_4 oxidase, subunit K00425 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 566.0
HKD2_k127_7902351_5 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K11085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009593 515.0
HKD2_k127_7902351_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009142 433.0
HKD2_k127_7902351_7 Competence protein ComEC Rec2 K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 456.0
HKD2_k127_7902351_8 COG4257 Streptogramin lyase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 442.0
HKD2_k127_7902351_9 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 401.0
HKD2_k127_7943361_0 PFAM glycoside hydrolase 15-related K01178 - 3.2.1.3 1.833e-321 1012.0
HKD2_k127_7943361_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 583.0
HKD2_k127_7943361_10 - - - - 0.000000000000000000000000000000000000000000000000000000000000000006165 233.0
HKD2_k127_7943361_11 Bacterial capsule synthesis protein PGA_cap K07282 - - 0.0000000000000000000000000000000000000000000000000002428 201.0
HKD2_k127_7943361_12 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000006264 188.0
HKD2_k127_7943361_13 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000001827 165.0
HKD2_k127_7943361_14 Uncharacterized protein conserved in bacteria (DUF2064) K09931 - - 0.0000000000000000000000000000000000003043 152.0
HKD2_k127_7943361_15 - - - - 0.000000000000000000000000000000005247 132.0
HKD2_k127_7943361_16 Amidohydrolase - - - 0.00001629 48.0
HKD2_k127_7943361_2 Radical SAM superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 377.0
HKD2_k127_7943361_3 converts alpha-aldose to the beta-anomer - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 359.0
HKD2_k127_7943361_4 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 364.0
HKD2_k127_7943361_5 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 353.0
HKD2_k127_7943361_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007057 304.0
HKD2_k127_7943361_7 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001787 284.0
HKD2_k127_7943361_8 ROK family K00886 - 2.7.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005013 273.0
HKD2_k127_7943361_9 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001599 253.0
HKD2_k127_7984620_0 Phosphoglucomutase/phosphomannomutase, C-terminal domain K01835 - 5.4.2.2 3.738e-258 806.0
HKD2_k127_7990439_0 PFAM Amidohydrolase 3 - - - 3.08e-205 652.0
HKD2_k127_7990439_1 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006225 497.0
HKD2_k127_7990439_10 Transcriptional regulator, ModE family K02019 - - 0.000000000000000000000001196 108.0
HKD2_k127_7990439_11 YCII-related domain K09780 - - 0.0000000000000000000003934 99.0
HKD2_k127_7990439_12 PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C K07259 - 3.4.16.4 0.000004207 49.0
HKD2_k127_7990439_13 Domain of unknown function (DU1801) - - - 0.00004342 47.0
HKD2_k127_7990439_2 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 300.0
HKD2_k127_7990439_4 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006318 255.0
HKD2_k127_7990439_5 endonuclease activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000003709 252.0
HKD2_k127_7990439_6 Belongs to the UPF0502 family K09915 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000007864 214.0
HKD2_k127_7990439_7 Acid phosphatase homologues K09474 - 3.1.3.2 0.00000000000000000000000000000000000000000000000000000000001169 218.0
HKD2_k127_7990439_8 LemA family K03744 - - 0.00000000000000000000000000000000000000000000911 168.0
HKD2_k127_7990439_9 Transport of potassium into the cell K03549 - - 0.000000000000000000000000000005902 124.0
HKD2_k127_8003350_0 GMC oxidoreductase K06151,K08261,K19813 - 1.1.5.9,1.1.99.21,1.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 563.0
HKD2_k127_8003350_1 Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB K16092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 541.0
HKD2_k127_8003350_10 Citrate transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009864 389.0
HKD2_k127_8003350_11 FAD binding domain K00486 - 1.14.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001014 395.0
HKD2_k127_8003350_12 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008482 362.0
HKD2_k127_8003350_13 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 349.0
HKD2_k127_8003350_14 SurA N-terminal domain K03771 GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005791 353.0
HKD2_k127_8003350_15 Cytochrome C biogenesis protein transmembrane region K08970 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 335.0
HKD2_k127_8003350_16 membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 321.0
HKD2_k127_8003350_17 PFAM amino acid permease-associated region K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007257 323.0
HKD2_k127_8003350_18 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 324.0
HKD2_k127_8003350_19 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007356 306.0
HKD2_k127_8003350_2 von Willebrand factor, type A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006485 544.0
HKD2_k127_8003350_20 oxidoreductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000381 304.0
HKD2_k127_8003350_21 Domain of unknown function (DUF4159) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001371 282.0
HKD2_k127_8003350_22 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009457 285.0
HKD2_k127_8003350_23 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000001829 278.0
HKD2_k127_8003350_24 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004359 263.0
HKD2_k127_8003350_25 Nucleotidyl transferase K00992 - 2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000000000001698 248.0
HKD2_k127_8003350_26 3-hydroxyanthranilic acid dioxygenase K00452 - 1.13.11.6 0.00000000000000000000000000000000000000000000000000000000000000000001528 237.0
HKD2_k127_8003350_27 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01684 - 4.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000002178 234.0
HKD2_k127_8003350_28 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000004306 229.0
HKD2_k127_8003350_29 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000001479 245.0
HKD2_k127_8003350_3 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 553.0
HKD2_k127_8003350_30 COG0811 Biopolymer transport proteins - - - 0.00000000000000000000000000000000000000000000000000000000004046 214.0
HKD2_k127_8003350_31 Peptidase C14 caspase catalytic subunit p20 - - - 0.0000000000000000000000000000000000000000000000001925 192.0
HKD2_k127_8003350_32 - - - - 0.000000000000000000000000000000000000000005278 166.0
HKD2_k127_8003350_33 Metal-sensitive transcriptional repressor K07807 - - 0.000000000000000000000000000000000005802 151.0
HKD2_k127_8003350_34 - - - - 0.000000000000000000000001029 108.0
HKD2_k127_8003350_35 - - - - 0.000000000000000000008707 105.0
HKD2_k127_8003350_36 - - - - 0.00000000000000111 88.0
HKD2_k127_8003350_37 metal-dependent hydrolase with the TIM-barrel fold - - - 0.0000000009887 72.0
HKD2_k127_8003350_4 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 494.0
HKD2_k127_8003350_5 PFAM thiamine pyrophosphate enzyme-like TPP-binding thiamine pyrophosphate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007255 466.0
HKD2_k127_8003350_6 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0019439,GO:0019441,GO:0019752,GO:0030429,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.7.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 445.0
HKD2_k127_8003350_7 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003045 457.0
HKD2_k127_8003350_8 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004689 433.0
HKD2_k127_8003350_9 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004755 426.0
HKD2_k127_8088108_0 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K12141 - - 3.316e-241 752.0
HKD2_k127_8088108_1 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 434.0
HKD2_k127_8088108_2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 328.0
HKD2_k127_8088108_3 hydrogenase 4 membrane K12140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001351 259.0
HKD2_k127_8088108_4 Proton-conducting membrane transporter - - - 0.0002543 44.0
HKD2_k127_8102941_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 6.602e-262 811.0
HKD2_k127_8102941_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 375.0
HKD2_k127_8102941_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.000171 44.0
HKD2_k127_81214_0 fumarylacetoacetate (FAA) hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 501.0
HKD2_k127_81214_1 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002278 412.0
HKD2_k127_81214_2 Short-chain dehydrogenase reductase sdr K18335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004844 342.0
HKD2_k127_81214_3 Toxic component of a toxin-antitoxin (TA) module. An RNase K07064 - - 0.0000000000000000000000000000000000005733 157.0
HKD2_k127_81214_4 - - GO:0008150,GO:0009605,GO:0009607,GO:0043207,GO:0044403,GO:0044419,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0075136 - 0.00000000000000000006548 91.0
HKD2_k127_81214_5 mandelate racemase muconate lactonizing K01706 - 4.2.1.40 0.000000000000000001259 85.0
HKD2_k127_8216769_0 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 577.0
HKD2_k127_8216769_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006926 572.0
HKD2_k127_8216769_10 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008496 315.0
HKD2_k127_8216769_11 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - 0.000000000000000000000000000000000001875 158.0
HKD2_k127_8216769_12 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000000000008518 132.0
HKD2_k127_8216769_13 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.0000000000002924 81.0
HKD2_k127_8216769_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 421.0
HKD2_k127_8216769_3 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004413 421.0
HKD2_k127_8216769_4 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000475 396.0
HKD2_k127_8216769_5 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000203 407.0
HKD2_k127_8216769_6 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 399.0
HKD2_k127_8216769_7 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 372.0
HKD2_k127_8216769_8 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 348.0
HKD2_k127_8216769_9 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 318.0
HKD2_k127_823957_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1569.0
HKD2_k127_823957_1 Heat shock 70 kDa protein K04043 - - 5.3e-322 995.0
HKD2_k127_823957_10 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 289.0
HKD2_k127_823957_11 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007615 275.0
HKD2_k127_823957_12 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000001222 270.0
HKD2_k127_823957_13 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000001126 261.0
HKD2_k127_823957_14 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000000000000000000000007873 216.0
HKD2_k127_823957_15 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000003045 215.0
HKD2_k127_823957_16 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000000003442 218.0
HKD2_k127_823957_17 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000000003855 201.0
HKD2_k127_823957_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000000000000000000000005649 174.0
HKD2_k127_823957_19 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000001426 144.0
HKD2_k127_823957_2 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 2.415e-304 944.0
HKD2_k127_823957_20 Polyketide cyclase / dehydrase and lipid transport - - - 0.00000000000000000000000000000000009284 139.0
HKD2_k127_823957_21 PFAM Preprotein translocase SecG subunit K03075 - - 0.0000000000000000000000419 104.0
HKD2_k127_823957_22 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.00000000000000007088 89.0
HKD2_k127_823957_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 6.628e-197 616.0
HKD2_k127_823957_4 Belongs to the CarA family K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 548.0
HKD2_k127_823957_5 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004209 520.0
HKD2_k127_823957_6 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004132 512.0
HKD2_k127_823957_7 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 469.0
HKD2_k127_823957_8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003363 389.0
HKD2_k127_823957_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 304.0
HKD2_k127_8282278_0 xanthine dehydrogenase a b hammerhead K11177 - 1.17.1.4 5.585e-235 751.0
HKD2_k127_8282278_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00018,K00058,K03778 - 1.1.1.28,1.1.1.29,1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 428.0
HKD2_k127_8282278_10 protein conserved in bacteria containing a divergent form of TPR repeats - - - 0.000000000000000000000000000000000000000000000002554 182.0
HKD2_k127_8282278_11 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.00000000000000000000000000000000000000002379 155.0
HKD2_k127_8282278_12 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000001757 154.0
HKD2_k127_8282278_13 PQQ-dependent polyvinyl alcohol dehydrogenase - - - 0.00000000000000000000000000000000000297 150.0
HKD2_k127_8282278_14 - - - - 0.000000000000000000000005495 114.0
HKD2_k127_8282278_15 Peptidase family S51 - - - 0.0000000000000001726 91.0
HKD2_k127_8282278_16 Cytochrome c - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000001051 79.0
HKD2_k127_8282278_17 PFAM AMP-dependent synthetase - - - 0.00000000006606 75.0
HKD2_k127_8282278_18 - - - - 0.0007838 48.0
HKD2_k127_8282278_2 PFAM Molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007848 407.0
HKD2_k127_8282278_3 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 405.0
HKD2_k127_8282278_4 PFAM EAL domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005065 373.0
HKD2_k127_8282278_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009482 301.0
HKD2_k127_8282278_6 Cysteine desulfurase K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 302.0
HKD2_k127_8282278_7 Trypsin-like peptidase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002642 276.0
HKD2_k127_8282278_8 2Fe-2S -binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000033 242.0
HKD2_k127_8282278_9 formate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000003862 193.0
HKD2_k127_8282824_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1260.0
HKD2_k127_8282824_1 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 7.479e-199 627.0
HKD2_k127_8282824_10 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.000000000000000000000000000006746 131.0
HKD2_k127_8282824_11 helix_turn_helix, Arsenical Resistance Operon Repressor K22042 - - 0.00000000000000000000000008284 119.0
HKD2_k127_8282824_12 Protein of unknown function (DUF2892) - - - 0.000000000000000000000007601 104.0
HKD2_k127_8282824_13 carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.00000000000000000000003835 107.0
HKD2_k127_8282824_2 FAD-NAD(P)-binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 443.0
HKD2_k127_8282824_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007939 302.0
HKD2_k127_8282824_4 branched-chain amino acid permease (azaleucine resistance) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 285.0
HKD2_k127_8282824_5 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002932 273.0
HKD2_k127_8282824_6 DSBA oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001925 262.0
HKD2_k127_8282824_7 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000009537 243.0
HKD2_k127_8282824_8 PFAM branched-chain amino acid transport - - - 0.00000000000000000000000000000000000005047 145.0
HKD2_k127_8282824_9 COG4993 Glucose dehydrogenase - - - 0.00000000000000000000000000000000946 132.0
HKD2_k127_8323679_0 glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 7.288e-256 799.0
HKD2_k127_8404781_0 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008968 457.0
HKD2_k127_8404781_1 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003964 309.0
HKD2_k127_8419763_0 Sodium/calcium exchanger protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007589 484.0
HKD2_k127_8419763_1 Acetamidase/Formamidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005004 393.0
HKD2_k127_8422685_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - 2.099e-243 777.0
HKD2_k127_8422685_1 DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K03732 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005805 510.0
HKD2_k127_8422685_10 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005911 328.0
HKD2_k127_8422685_11 COG3202 ATP ADP translocase K03301 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 335.0
HKD2_k127_8422685_12 PFAM ErfK YbiS YcfS YnhG family protein K16291 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 306.0
HKD2_k127_8422685_13 COG1218 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase K01082 GO:0000103,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 295.0
HKD2_k127_8422685_14 Protein of unknown function (DUF1211) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 291.0
HKD2_k127_8422685_15 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 302.0
HKD2_k127_8422685_16 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001944 283.0
HKD2_k127_8422685_17 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000006526 272.0
HKD2_k127_8422685_18 Oxygen tolerance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001328 280.0
HKD2_k127_8422685_19 serine-type endopeptidase activity K13908,K21125 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002116 262.0
HKD2_k127_8422685_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 483.0
HKD2_k127_8422685_20 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001433 260.0
HKD2_k127_8422685_21 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000006618 239.0
HKD2_k127_8422685_22 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000002036 241.0
HKD2_k127_8422685_23 cellular modified histidine biosynthetic process K18802 - - 0.000000000000000000000000000000000000000000000000000000000000001995 229.0
HKD2_k127_8422685_24 Phage tail sheath C-terminal domain K06907 - - 0.00000000000000000000000000000000000000000000000000000000000007268 234.0
HKD2_k127_8422685_25 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000005005 217.0
HKD2_k127_8422685_26 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000002481 208.0
HKD2_k127_8422685_27 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000000000000000000000000000000000000000000459 198.0
HKD2_k127_8422685_28 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000001408 176.0
HKD2_k127_8422685_29 Belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.000000000000000000000000000000000000000000005159 166.0
HKD2_k127_8422685_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 482.0
HKD2_k127_8422685_30 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000002084 171.0
HKD2_k127_8422685_32 Type II secretory pathway, pseudopilin PulG K10924 - - 0.00000000000000000000357 98.0
HKD2_k127_8422685_34 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000003634 82.0
HKD2_k127_8422685_35 small protein containing a coiled-coil domain - - - 0.00000000000002202 76.0
HKD2_k127_8422685_4 Penicillin amidase K01434 - 3.5.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 490.0
HKD2_k127_8422685_5 MCM2/3/5 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 438.0
HKD2_k127_8422685_6 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004395 466.0
HKD2_k127_8422685_7 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000966 403.0
HKD2_k127_8422685_8 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 367.0
HKD2_k127_8422685_9 PFAM peptidase K04774 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005234 325.0
HKD2_k127_8598829_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 500.0
HKD2_k127_8598829_1 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 483.0
HKD2_k127_8598829_10 belongs to the nudix hydrolase family K03574 - 3.6.1.55 0.0000005238 58.0
HKD2_k127_8598829_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 468.0
HKD2_k127_8598829_3 ThiF family K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000005579 259.0
HKD2_k127_8598829_4 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001315 256.0
HKD2_k127_8598829_5 Mechanosensitive ion channel K03442 - - 0.000000000000000000000000000000000000000000000000000000000000000003271 239.0
HKD2_k127_8598829_6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000000000000000000000000007535 224.0
HKD2_k127_8598829_7 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.000000000000000000000000000000000000000000000000000000000147 228.0
HKD2_k127_8598829_8 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000000000000000007101 201.0
HKD2_k127_8598829_9 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.00000000000001182 85.0
HKD2_k127_87975_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1512.0
HKD2_k127_87975_1 ATPase (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001938 517.0
HKD2_k127_87975_10 Glutathione S-transferase, N-terminal domain K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 308.0
HKD2_k127_87975_11 Belongs to the GbsR family - - - 0.0000000000000000000000000000000000000000000000000000000000000005542 223.0
HKD2_k127_87975_12 - - - - 0.000000000000000000000000000000000000000000000000000000172 204.0
HKD2_k127_87975_13 protein containing a von Willebrand factor type A (vWA) domain K07114 - - 0.00000000000000000000000000000000000000000000000000001258 204.0
HKD2_k127_87975_14 homocysteine K00547 - 2.1.1.10 0.000000000000000000000000000000000000006008 158.0
HKD2_k127_87975_15 - - - - 0.000000000000000000000000003339 116.0
HKD2_k127_87975_2 Glutathione S-transferase, C-terminal domain K07393 GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 503.0
HKD2_k127_87975_3 Tannase and feruloyl esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 480.0
HKD2_k127_87975_4 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008955 444.0
HKD2_k127_87975_5 Biotin-lipoyl like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008735 409.0
HKD2_k127_87975_6 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004288 383.0
HKD2_k127_87975_7 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 411.0
HKD2_k127_87975_8 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 369.0
HKD2_k127_87975_9 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 322.0
HKD2_k127_8945655_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 583.0
HKD2_k127_8945655_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 376.0
HKD2_k127_8945655_2 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002261 368.0
HKD2_k127_8945655_3 Xylose isomerase-like TIM barrel K01816 - 5.3.1.22 0.00000000000000000000000000000000000000000000000000000000000000004846 235.0
HKD2_k127_8945655_4 ABC transporter K02003 - - 0.00000000000000000004402 90.0
HKD2_k127_8956616_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 8.514e-280 869.0
HKD2_k127_8956616_1 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 605.0
HKD2_k127_8956616_10 Two component response regulator for the phosphate regulon K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 306.0
HKD2_k127_8956616_11 protein methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 294.0
HKD2_k127_8956616_12 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001093 296.0
HKD2_k127_8956616_13 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001288 272.0
HKD2_k127_8956616_14 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000001568 239.0
HKD2_k127_8956616_15 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.0000000000000000000000000000000000000001733 164.0
HKD2_k127_8956616_16 PFAM Peptidase M22, glycoprotease K14742 - - 0.0000000000000000000000000000000000004056 158.0
HKD2_k127_8956616_17 TIGRFAM conserved repeat domain - - - 0.0000000000000003218 88.0
HKD2_k127_8956616_2 Helicase K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 569.0
HKD2_k127_8956616_3 epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001385 468.0
HKD2_k127_8956616_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 433.0
HKD2_k127_8956616_5 Belongs to the transferase hexapeptide repeat family K00674 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008666,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009987,GO:0016053,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016749,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003599 419.0
HKD2_k127_8956616_6 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 415.0
HKD2_k127_8956616_7 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 406.0
HKD2_k127_8956616_8 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005146 350.0
HKD2_k127_8956616_9 Signal transduction histidine kinase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 346.0
HKD2_k127_8997931_0 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004846 441.0
HKD2_k127_8997931_1 protein involved in propionate catabolism - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 370.0
HKD2_k127_9015538_0 TonB dependent receptor K02014 - - 7.233e-281 889.0
HKD2_k127_9015538_1 Mo-co oxidoreductase dimerisation domain K17225 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 501.0
HKD2_k127_9015538_10 YCII-related domain - - - 0.000000000000000000000002399 106.0
HKD2_k127_9015538_11 - - - - 0.00000000000000000000001812 117.0
HKD2_k127_9015538_13 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0004353 44.0
HKD2_k127_9015538_2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 339.0
HKD2_k127_9015538_3 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 327.0
HKD2_k127_9015538_4 glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002619 293.0
HKD2_k127_9015538_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000003949 224.0
HKD2_k127_9015538_6 deacetylase K06986 - - 0.00000000000000000000000000000000000000000000000000000001824 210.0
HKD2_k127_9015538_7 Cytochrome C oxidase, cbb3-type, subunit III K08738 - - 0.000000000000000000000000000000000000000000000000000003091 198.0
HKD2_k127_9015538_8 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000003024 143.0
HKD2_k127_9015538_9 - - - - 0.0000000000000000000000002285 119.0
HKD2_k127_9026350_0 NHL repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007373 332.0
HKD2_k127_9026350_1 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000000000000000006045 168.0
HKD2_k127_9026350_2 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.000003366 59.0
HKD2_k127_9028724_0 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 7.353e-245 784.0
HKD2_k127_9028724_1 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 - 6.1.1.18 5.975e-237 745.0
HKD2_k127_9028724_10 Domain of unknown function (DUF4266) - - - 0.000000000000000000000009952 102.0
HKD2_k127_9028724_11 ABC transporter K02003 - - 0.00000000000000000001906 91.0
HKD2_k127_9028724_12 SOCS_box - - - 0.00000003262 63.0
HKD2_k127_9028724_13 Tetratricopeptide repeat - - - 0.000006179 55.0
HKD2_k127_9028724_14 Biopolymer transporter TonB K03832 - - 0.0006241 51.0
HKD2_k127_9028724_2 Protein of unknown function (DUF3570) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004726 431.0
HKD2_k127_9028724_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 406.0
HKD2_k127_9028724_4 MacB-like periplasmic core domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 405.0
HKD2_k127_9028724_5 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005334 350.0
HKD2_k127_9028724_6 molybdopterin biosynthesis K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 344.0
HKD2_k127_9028724_7 COG3103 SH3 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008595 246.0
HKD2_k127_9028724_8 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000000000000000000000000000000000000001608 229.0
HKD2_k127_9028724_9 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000000003204 192.0
HKD2_k127_9042028_0 SNF2 family N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 314.0
HKD2_k127_9042028_1 MacB-like periplasmic core domain - - - 0.000000000000001725 78.0
HKD2_k127_9042028_2 DNA restriction-modification system - - - 0.00004046 47.0
HKD2_k127_9054019_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 2.366e-303 946.0
HKD2_k127_9054019_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - 1.332e-300 933.0
HKD2_k127_9054019_10 lysine 2,3-aminomutase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007675 345.0
HKD2_k127_9054019_11 Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000517 305.0
HKD2_k127_9054019_12 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 313.0
HKD2_k127_9054019_13 PFAM EAL domain K21025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 321.0
HKD2_k127_9054019_14 PhoPQ-activated pathogenicity-related protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 302.0
HKD2_k127_9054019_15 Methyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003265 284.0
HKD2_k127_9054019_16 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001217 265.0
HKD2_k127_9054019_17 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 - 2.1.1.298 0.0000000000000000000000000000000000000000000000000000000000000000000000000006959 265.0
HKD2_k127_9054019_18 Elongation factor P--(R)-beta-lysine ligase K04568 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000358 276.0
HKD2_k127_9054019_19 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000001913 250.0
HKD2_k127_9054019_2 Cysteine-rich domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 584.0
HKD2_k127_9054019_20 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000003193 249.0
HKD2_k127_9054019_21 Protein of unknown function (DUF3501) - - - 0.00000000000000000000000000000000000000000000000000000000000000007517 229.0
HKD2_k127_9054019_22 FimV C-terminal K08086 - - 0.0000000000000000000000000000000000000000000000000000000000000003304 251.0
HKD2_k127_9054019_23 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000001013 218.0
HKD2_k127_9054019_24 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000004869 214.0
HKD2_k127_9054019_25 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000003717 201.0
HKD2_k127_9054019_26 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.0000000000000000000000000000000000000006072 154.0
HKD2_k127_9054019_27 STAS-like domain of unknown function (DUF4325) - - - 0.000000000000000000000000000000000000003857 153.0
HKD2_k127_9054019_28 PFAM electron transport protein SCO1 SenC K07152 - - 0.00000000000000000000000000000000000001298 154.0
HKD2_k127_9054019_29 Protein of unknown function (DUF3313) - - - 0.000000000000000000000000000000000171 139.0
HKD2_k127_9054019_3 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 546.0
HKD2_k127_9054019_30 SnoaL-like domain - - - 0.000000000000000000000000000000002577 132.0
HKD2_k127_9054019_31 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000008526 120.0
HKD2_k127_9054019_32 SnoaL-like domain - - - 0.0000000000000000000000000221 118.0
HKD2_k127_9054019_33 - - - - 0.00000000000000000009648 94.0
HKD2_k127_9054019_34 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 0.00000000000000006333 83.0
HKD2_k127_9054019_35 - - - - 0.0000000000000001052 92.0
HKD2_k127_9054019_36 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000007947 74.0
HKD2_k127_9054019_4 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 512.0
HKD2_k127_9054019_5 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 464.0
HKD2_k127_9054019_6 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003477 406.0
HKD2_k127_9054019_7 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 370.0
HKD2_k127_9054019_8 Ankyrin repeats (3 copies) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 379.0
HKD2_k127_9054019_9 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 365.0
HKD2_k127_9079116_0 Efflux pump membrane transporter K18299,K18902 - - 0.0 1206.0
HKD2_k127_9079116_1 xanthine dehydrogenase activity - - - 0.0 1048.0
HKD2_k127_9079116_10 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 316.0
HKD2_k127_9079116_11 unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008852 325.0
HKD2_k127_9079116_12 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 302.0
HKD2_k127_9079116_13 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000543 295.0
HKD2_k127_9079116_14 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001704 273.0
HKD2_k127_9079116_15 2Fe-2S -binding domain protein K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000926 258.0
HKD2_k127_9079116_16 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000334 270.0
HKD2_k127_9079116_17 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000008247 237.0
HKD2_k127_9079116_18 Beta-lactamase K18988 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000005833 232.0
HKD2_k127_9079116_19 NADP oxidoreductase, coenzyme f420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000000000000000006953 235.0
HKD2_k127_9079116_2 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 8.787e-318 1003.0
HKD2_k127_9079116_20 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000112 214.0
HKD2_k127_9079116_21 - - - - 0.0000000000000000000000000000000000000000000000000001047 198.0
HKD2_k127_9079116_22 - - - - 0.000000000000000000000000000000000000000000000000003216 204.0
HKD2_k127_9079116_23 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000000000000009441 173.0
HKD2_k127_9079116_24 Beta-lactamase - - - 0.0000000000000000000000000000000000000003186 172.0
HKD2_k127_9079116_25 FR47-like protein K06976 - - 0.00000000000000000000000000000000000008559 153.0
HKD2_k127_9079116_26 DnaK suppressor protein - - - 0.000000000000000000000000000000000001006 140.0
HKD2_k127_9079116_27 COG0457 FOG TPR repeat - - - 0.000000000000000000000000002463 127.0
HKD2_k127_9079116_28 - - - - 0.0000000000000000000000446 103.0
HKD2_k127_9079116_29 Large family of predicted nucleotide-binding domains - - - 0.0000000000000000000006978 108.0
HKD2_k127_9079116_3 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 5.178e-284 890.0
HKD2_k127_9079116_30 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000002013 97.0
HKD2_k127_9079116_31 - - - - 0.0000000000000001949 92.0
HKD2_k127_9079116_32 PFAM Photosynthetic reaction centre cytochrome C subunit K13992 - - 0.0000000000000004563 92.0
HKD2_k127_9079116_34 - - - - 0.0000000000004312 81.0
HKD2_k127_9079116_36 efflux transmembrane transporter activity K02004 - - 0.00000000168 59.0
HKD2_k127_9079116_4 4-hydroxyphenylacetate 3-hydroxylase C terminal K00483,K14534 - 1.14.14.9,4.2.1.120,5.3.3.3 2.082e-205 650.0
HKD2_k127_9079116_5 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 577.0
HKD2_k127_9079116_6 FAD linked oxidase domain protein K05797 - 1.17.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005691 554.0
HKD2_k127_9079116_7 COG3209 Rhs family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 417.0
HKD2_k127_9079116_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K18298,K18901 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001831 370.0
HKD2_k127_9079116_9 domain, Protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 340.0
HKD2_k127_9084147_0 Aldehyde dehydrogenase family K00128,K00146 - 1.2.1.3,1.2.1.39 1.325e-235 736.0
HKD2_k127_9084147_1 ketosteroid isomerase - - - 0.000000000000000635 85.0
HKD2_k127_9148826_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002851 616.0
HKD2_k127_9148826_1 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 550.0
HKD2_k127_9148826_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003241 319.0
HKD2_k127_9148826_3 Protein of unknown function (DUF4199) - - - 0.00000000000000000000000000000000000000001524 160.0
HKD2_k127_9148826_4 PFAM regulatory protein LuxR - - - 0.00000000000000000000000000000000000000335 150.0
HKD2_k127_9148826_5 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters K03557 GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000006831 96.0
HKD2_k127_9148826_6 Protein of unknown function (DUF3426) - - - 0.000007552 55.0
HKD2_k127_9153450_0 protein conserved in bacteria - - - 1.546e-224 715.0
HKD2_k127_9153450_1 Reductase C-terminal K05297 - 1.18.1.1 1.469e-194 619.0
HKD2_k127_9153450_10 Ribbon-helix-helix protein, copG family - - - 0.0004488 47.0
HKD2_k127_9153450_2 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 466.0
HKD2_k127_9153450_3 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 411.0
HKD2_k127_9153450_4 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006212 377.0
HKD2_k127_9153450_5 Binding-protein-dependent transport system inner membrane component K02038 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 339.0
HKD2_k127_9153450_6 transposition K07497 - - 0.000000000000000000000000000000000000000000000000001913 187.0
HKD2_k127_9153450_7 transposition K07497 - - 0.000000000000000000000007517 107.0
HKD2_k127_9153450_8 Toxic component of a toxin-antitoxin (TA) module. An RNase K07065 - - 0.0000000000003921 75.0
HKD2_k127_9153450_9 - - - - 0.000000002296 62.0
HKD2_k127_9174120_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1449.0
HKD2_k127_9174120_1 Belongs to the IlvD Edd family - - - 2.859e-211 681.0
HKD2_k127_9174120_10 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001447 260.0
HKD2_k127_9174120_11 - - - - 0.000000000000000000000000000000000000000000000000000543 204.0
HKD2_k127_9174120_12 O-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000006461 206.0
HKD2_k127_9174120_13 PFAM periplasmic binding protein K02016 - - 0.000000000000000000000000000000000000000000000000001694 195.0
HKD2_k127_9174120_14 Sh3 type 3 domain protein K01361 - 3.4.21.96 0.000000000000000000000000000000000000001287 158.0
HKD2_k127_9174120_15 arsenate reductase K00537 - 1.20.4.1 0.0000000000000000000000000000000000001797 148.0
HKD2_k127_9174120_16 Response regulator receiver K15012 - - 0.000000000000000000000000196 110.0
HKD2_k127_9174120_17 Belongs to the mannose-6-phosphate isomerase type 2 family K16011 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.7.7.13,5.3.1.8 0.00000000000000000005111 104.0
HKD2_k127_9174120_18 Metal-sensitive transcriptional repressor K07807 - - 0.000000000000000006493 83.0
HKD2_k127_9174120_19 - - - - 0.000000008808 65.0
HKD2_k127_9174120_2 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006737 576.0
HKD2_k127_9174120_3 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008895 496.0
HKD2_k127_9174120_4 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain K04771,K04772 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008201 439.0
HKD2_k127_9174120_5 COG2133 Glucose sorbosone dehydrogenases K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008667 391.0
HKD2_k127_9174120_6 Two-component sensor kinase N-terminal K07649 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 357.0
HKD2_k127_9174120_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006935 324.0
HKD2_k127_9174120_8 outer membrane efflux protein K15725 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 300.0
HKD2_k127_9174120_9 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000004754 263.0
HKD2_k127_9204627_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 2257.0
HKD2_k127_9204627_1 PFAM Orn DAP Arg decarboxylase 2 K01585 - 4.1.1.19 5.416e-219 698.0
HKD2_k127_9204627_10 Glucose / Sorbosone dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000724 476.0
HKD2_k127_9204627_11 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K12251 - 3.5.1.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002645 430.0
HKD2_k127_9204627_12 Glutamate-cysteine ligase family 2(GCS2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003053 417.0
HKD2_k127_9204627_13 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 414.0
HKD2_k127_9204627_14 Major facilitator Superfamily K03762 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 383.0
HKD2_k127_9204627_15 ATP-grasp domain K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007001 376.0
HKD2_k127_9204627_16 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 337.0
HKD2_k127_9204627_17 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 335.0
HKD2_k127_9204627_18 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 329.0
HKD2_k127_9204627_19 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 309.0
HKD2_k127_9204627_2 Peptidase dimerisation domain - - - 8.74e-198 627.0
HKD2_k127_9204627_20 KR domain K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006726 311.0
HKD2_k127_9204627_21 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 301.0
HKD2_k127_9204627_22 Peptidase_C39 like family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001899 274.0
HKD2_k127_9204627_23 Conserved Protein - - - 0.000000000000000000000000000000000000000000000000000000001263 206.0
HKD2_k127_9204627_24 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000061 207.0
HKD2_k127_9204627_25 M56 family peptidase - - - 0.00000000000000000000000000000000000000000000001336 190.0
HKD2_k127_9204627_26 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000003956 173.0
HKD2_k127_9204627_28 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000002294 163.0
HKD2_k127_9204627_29 Penicillinase repressor - - - 0.0000000000000000000000000000000000002352 144.0
HKD2_k127_9204627_3 Radical SAM superfamily K01843 - 5.4.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009517 588.0
HKD2_k127_9204627_30 - - - - 0.0000000000000000000000000000004762 137.0
HKD2_k127_9204627_31 Uncharacterized ACR, COG1678 K07735 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000004597 119.0
HKD2_k127_9204627_32 Domain of unknown function (DUF4154) - - - 0.00000000000000000000001451 108.0
HKD2_k127_9204627_33 PFAM lipolytic protein G-D-S-L family - - - 0.0000000000000000000001982 112.0
HKD2_k127_9204627_34 FMN_bind K19339 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000009679 86.0
HKD2_k127_9204627_35 Subtilase family - - - 0.00000008711 64.0
HKD2_k127_9204627_36 - - - - 0.000001425 57.0
HKD2_k127_9204627_37 FR47-like protein K06976 - - 0.00000725 58.0
HKD2_k127_9204627_38 - - - - 0.0002033 49.0
HKD2_k127_9204627_4 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 573.0
HKD2_k127_9204627_5 PFAM deoxyhypusine synthase K00809 - 2.5.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 539.0
HKD2_k127_9204627_6 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 552.0
HKD2_k127_9204627_7 Belongs to the citrate synthase family K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009311 533.0
HKD2_k127_9204627_8 RimK-like ATPgrasp N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 518.0
HKD2_k127_9204627_9 TonB-dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 503.0
HKD2_k127_9238761_0 Protein of unknown function (DUF1214) - - - 6.144e-249 775.0
HKD2_k127_9238761_1 Homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000002352 240.0
HKD2_k127_9238761_2 Threonine synthase K01733 - 4.2.3.1 0.000000000000000000000000000000000000001797 157.0
HKD2_k127_9273627_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1137.0
HKD2_k127_9273627_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 1.909e-318 987.0
HKD2_k127_9273627_10 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 446.0
HKD2_k127_9273627_11 Sugar (and other) transporter K08195 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 441.0
HKD2_k127_9273627_12 Citrate synthase, C-terminal domain K01647 - 2.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 415.0
HKD2_k127_9273627_13 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 407.0
HKD2_k127_9273627_14 Belongs to the peptidase S1C family K04771,K04772 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 412.0
HKD2_k127_9273627_15 Helix-turn-helix domain K01647 - 2.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007694 361.0
HKD2_k127_9273627_16 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 362.0
HKD2_k127_9273627_17 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009245 334.0
HKD2_k127_9273627_18 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 326.0
HKD2_k127_9273627_19 COG0209 Ribonucleotide reductase, alpha subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004635 299.0
HKD2_k127_9273627_2 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 1.359e-208 655.0
HKD2_k127_9273627_20 type I secretion outer membrane protein, TolC K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006089 302.0
HKD2_k127_9273627_21 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000021 270.0
HKD2_k127_9273627_22 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000002359 250.0
HKD2_k127_9273627_23 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000123 248.0
HKD2_k127_9273627_24 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000000000001853 243.0
HKD2_k127_9273627_25 N-formylglutamate amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000005461 233.0
HKD2_k127_9273627_26 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000001972 218.0
HKD2_k127_9273627_27 - - - - 0.00000000000000000000000000000000000000000000000000000118 214.0
HKD2_k127_9273627_28 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464 6.3.2.45 0.0000000000000000000000000000000000000000000001043 170.0
HKD2_k127_9273627_29 VIT family - - - 0.000000000000000000000000000000000000000000007382 174.0
HKD2_k127_9273627_3 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003537 604.0
HKD2_k127_9273627_30 Outer membrane protein beta-barrel domain - - - 0.000000000000000000000000000000000000003286 154.0
HKD2_k127_9273627_31 Belongs to the UPF0307 family K09889 - - 0.000000000000000000000000000000000002125 145.0
HKD2_k127_9273627_32 PFAM Rhodanese domain protein - - - 0.000000000000000000000000002035 115.0
HKD2_k127_9273627_33 - - - - 0.0000000000000000000000012 115.0
HKD2_k127_9273627_34 aminopeptidase - - - 0.00000000000000000000009953 102.0
HKD2_k127_9273627_35 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000007367 104.0
HKD2_k127_9273627_37 - - - - 0.000000000301 69.0
HKD2_k127_9273627_38 cytochrome - - - 0.0000000009505 67.0
HKD2_k127_9273627_4 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 604.0
HKD2_k127_9273627_5 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003068 550.0
HKD2_k127_9273627_6 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 518.0
HKD2_k127_9273627_7 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 525.0
HKD2_k127_9273627_8 Belongs to the glutaminase family K01425 - 3.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001276 471.0
HKD2_k127_9273627_9 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009203 478.0
HKD2_k127_9284303_0 NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 397.0
HKD2_k127_9284303_1 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 369.0
HKD2_k127_9284303_2 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 286.0
HKD2_k127_9284303_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001528 274.0
HKD2_k127_9284303_4 Protein of unknown function (DUF2799) - - - 0.0000000000000000000000000000000000178 149.0
HKD2_k127_9284303_5 Subtilase family K14645 - - 0.00000000004026 70.0
HKD2_k127_9412825_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 1.022e-247 782.0
HKD2_k127_9412825_1 Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) K01876 - 6.1.1.12 1.156e-245 772.0
HKD2_k127_9412825_2 Glucose / Sorbosone dehydrogenase - - - 5.733e-218 681.0
HKD2_k127_9412825_3 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000268 169.0
HKD2_k127_9412825_4 pfam nudix K08310 - 3.6.1.67 0.00000000000000000000000000000007122 144.0
HKD2_k127_9412825_5 - - - - 0.000001185 58.0
HKD2_k127_9413308_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123,K22015 GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0015942,GO:0015944,GO:0016491,GO:0016651,GO:0016999,GO:0017144,GO:0019752,GO:0030151,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704 1.17.1.9,1.17.99.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 514.0
HKD2_k127_9413308_1 L-lactate dehydrogenase K00101 - 1.1.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008543 435.0
HKD2_k127_9413308_2 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002163 262.0
HKD2_k127_9413308_3 Histidine kinase - - - 0.000000000000000000000000000000000000003025 154.0
HKD2_k127_9413308_4 NADH-dependant formate dehydrogenase delta subunit FdsD K00126 - 1.17.1.9 0.00000001195 59.0
HKD2_k127_9479427_0 COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components K06147 - - 7.732e-251 789.0
HKD2_k127_9479427_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 601.0
HKD2_k127_9479427_10 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004507 428.0
HKD2_k127_9479427_11 N-acetylmuramoyl-L-alanine amidase K01448 GO:0000003,GO:0000910,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0008745,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019954,GO:0022402,GO:0022414,GO:0030288,GO:0030313,GO:0031975,GO:0032505,GO:0042597,GO:0043093,GO:0044464,GO:0051301,GO:0061783 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001558 395.0
HKD2_k127_9479427_12 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 362.0
HKD2_k127_9479427_13 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008026 325.0
HKD2_k127_9479427_14 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 322.0
HKD2_k127_9479427_15 HflC and HflK could encode or regulate a protease K04088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 319.0
HKD2_k127_9479427_16 polyphosphate kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006157 302.0
HKD2_k127_9479427_17 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001162 287.0
HKD2_k127_9479427_18 Deoxynucleoside kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006834 265.0
HKD2_k127_9479427_19 methyltransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003526 254.0
HKD2_k127_9479427_2 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009403 562.0
HKD2_k127_9479427_20 Glycosyl Transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009894 259.0
HKD2_k127_9479427_21 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000003717 256.0
HKD2_k127_9479427_22 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000001341 244.0
HKD2_k127_9479427_23 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001165 237.0
HKD2_k127_9479427_24 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000003728 240.0
HKD2_k127_9479427_25 TIGRFAM methyltransferase FkbM family - - - 0.000000000000000000000000000000000000000000000601 175.0
HKD2_k127_9479427_26 Hydrolase - - - 0.0000000000000000000000000000000000003401 156.0
HKD2_k127_9479427_27 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016246,GO:0016441,GO:0016458,GO:0017148,GO:0019222,GO:0022607,GO:0022613,GO:0022618,GO:0030423,GO:0031047,GO:0031123,GO:0031124,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032269,GO:0032270,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0035194,GO:0040029,GO:0040033,GO:0043170,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045974,GO:0045975,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113 - 0.000000000000000000000000000000000001806 139.0
HKD2_k127_9479427_28 Amidohydrolase family - - - 0.0000000000000000000000000001354 124.0
HKD2_k127_9479427_29 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000002966 119.0
HKD2_k127_9479427_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 565.0
HKD2_k127_9479427_30 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.000000002466 61.0
HKD2_k127_9479427_31 FeoA K04758 - - 0.00000000773 60.0
HKD2_k127_9479427_32 - - - - 0.0007228 51.0
HKD2_k127_9479427_4 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000516 541.0
HKD2_k127_9479427_5 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 476.0
HKD2_k127_9479427_6 Asparagine synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 460.0
HKD2_k127_9479427_7 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007829 452.0
HKD2_k127_9479427_8 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002323 448.0
HKD2_k127_9479427_9 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007718 445.0
HKD2_k127_9506823_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1209.0
HKD2_k127_9506823_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 3.78e-262 824.0
HKD2_k127_9506823_10 PFAM Type II secretion system protein E K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 420.0
HKD2_k127_9506823_11 Transglutaminase/protease-like homologues K22452 - 2.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004959 438.0
HKD2_k127_9506823_12 short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 400.0
HKD2_k127_9506823_13 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002529 372.0
HKD2_k127_9506823_14 Part of a membrane complex involved in electron transport K03614 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 367.0
HKD2_k127_9506823_15 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 347.0
HKD2_k127_9506823_16 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 324.0
HKD2_k127_9506823_17 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000001018 264.0
HKD2_k127_9506823_18 TIGRFAM Phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000009979 268.0
HKD2_k127_9506823_19 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004572 263.0
HKD2_k127_9506823_2 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 6.032e-239 749.0
HKD2_k127_9506823_20 Belongs to the WrbA family K03809 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000000001982 241.0
HKD2_k127_9506823_21 Permease YjgP YjgQ family K07091 - - 0.00000000000000000000000000000000000000000000000000000000000000000002668 246.0
HKD2_k127_9506823_22 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000008514 235.0
HKD2_k127_9506823_23 Rnf-Nqr subunit, membrane protein K03617 - - 0.000000000000000000000000000000000000000000000000000001892 202.0
HKD2_k127_9506823_24 Part of a membrane complex involved in electron transport K03613 - - 0.00000000000000000000000000000000000000000000000000000218 202.0
HKD2_k127_9506823_25 PFAM Lytic transglycosylase catalytic - - - 0.000000000000000000000000000000000000000000000000000005181 198.0
HKD2_k127_9506823_26 Permease YjgP YjgQ K11720 - - 0.0000000000000000000000000000000000000000000000006833 192.0
HKD2_k127_9506823_27 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000002596 171.0
HKD2_k127_9506823_28 Part of a membrane complex involved in electron transport K03612 - - 0.00000000000000000000000000000000000000000003467 169.0
HKD2_k127_9506823_29 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA K10763 GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - 0.0000000000000000000000000000000000000000001423 168.0
HKD2_k127_9506823_3 PFAM glycoside hydrolase family 3 domain protein K05349 - 3.2.1.21 9.792e-233 741.0
HKD2_k127_9506823_30 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.00000000000000000000000000000000000001913 150.0
HKD2_k127_9506823_31 COG2927 DNA polymerase III, chi subunit K02339 GO:0005575,GO:0005622,GO:0005623,GO:0006275,GO:0008150,GO:0009314,GO:0009360,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010556,GO:0010557,GO:0010604,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032298,GO:0032991,GO:0042575,GO:0043846,GO:0043847,GO:0044424,GO:0044464,GO:0045740,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051173,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:0090329,GO:1902494,GO:1990234,GO:2000105,GO:2000112 2.7.7.7 0.000000000000000000000000000002714 139.0
HKD2_k127_9506823_32 pfam rdd - - - 0.00000000000000000000000000002878 123.0
HKD2_k127_9506823_33 protein conserved in bacteria K09938 - - 0.00000000000000000000000001134 122.0
HKD2_k127_9506823_34 Protein of unknown function (DUF3108) - - - 0.000000000000000000000000743 113.0
HKD2_k127_9506823_35 GCN5-related N-acetyl-transferase K06975 - - 0.00000000000000002416 85.0
HKD2_k127_9506823_36 acylphosphatase activity K01512 GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 0.0000000000000001052 87.0
HKD2_k127_9506823_4 Protein tyrosine kinase - - - 3.325e-209 679.0
HKD2_k127_9506823_5 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 556.0
HKD2_k127_9506823_6 PFAM Type II secretion system protein E - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004432 525.0
HKD2_k127_9506823_7 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 475.0
HKD2_k127_9506823_8 PFAM natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000902 430.0
HKD2_k127_9506823_9 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003544 423.0
HKD2_k127_9523328_0 Belongs to the dihydroorotate dehydrogenase family K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000731 481.0
HKD2_k127_9523328_1 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008092 336.0
HKD2_k127_9523328_10 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.0000000000000000000000000002444 116.0
HKD2_k127_9523328_11 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000004315 89.0
HKD2_k127_9523328_12 Protein of unknown function (DUF3012) - - - 0.0000000000000856 73.0
HKD2_k127_9523328_13 - - - - 0.00000008582 64.0
HKD2_k127_9523328_14 involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.129 0.000002522 55.0
HKD2_k127_9523328_15 A domain in the BMP inhibitor chordin and in microbial proteins. - - - 0.00008006 51.0
HKD2_k127_9523328_2 Glycerol-3-phosphate dehydrogenase K00057 GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 329.0
HKD2_k127_9523328_3 COG4942 Membrane-bound metallopeptidase - GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000002256 244.0
HKD2_k127_9523328_4 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000005955 236.0
HKD2_k127_9523328_5 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.000000000000000000000000000000000000000000000000000000000000002128 222.0
HKD2_k127_9523328_6 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.000000000000000000000000000000000000007054 151.0
HKD2_k127_9523328_7 peptidylprolyl isomerase K03769 - 5.2.1.8 0.00000000000000000000000000000000000001725 147.0
HKD2_k127_9523328_8 RNA-binding - - - 0.00000000000000000000000000000006509 126.0
HKD2_k127_9523328_9 Sulfurtransferase - - - 0.0000000000000000000000000000433 125.0
HKD2_k127_9554763_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02474 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002089 611.0
HKD2_k127_9554763_1 PFAM NAD-dependent epimerase dehydratase K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003059 534.0
HKD2_k127_9554763_10 Belongs to the GPI family K01810 - 5.3.1.9 0.00000000006455 65.0
HKD2_k127_9554763_2 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 482.0
HKD2_k127_9554763_3 Catalyzes a key regulatory step in fatty acid biosynthesis K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004415 372.0
HKD2_k127_9554763_4 peptidylprolyl isomerase K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002036 301.0
HKD2_k127_9554763_5 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008271 274.0
HKD2_k127_9554763_6 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000003311 231.0
HKD2_k127_9554763_7 Methyltransferase domain - - - 0.0000000000000000000000000000000000000615 152.0
HKD2_k127_9554763_8 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000009419 89.0
HKD2_k127_9554763_9 - - - - 0.00000000000000226 78.0
HKD2_k127_9630618_0 Elongation factor SelB, winged helix K03833 - - 6.035e-207 683.0
HKD2_k127_9630618_1 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005753 561.0
HKD2_k127_9630618_10 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000000000995 224.0
HKD2_k127_9630618_11 Elongation factor SelB, winged helix K03833 - - 0.00000005106 63.0
HKD2_k127_9630618_2 NADPH quinone reductase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007666 540.0
HKD2_k127_9630618_3 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 565.0
HKD2_k127_9630618_4 alkaline phosphatase K01113 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007188 481.0
HKD2_k127_9630618_5 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006868 477.0
HKD2_k127_9630618_6 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008496 450.0
HKD2_k127_9630618_7 PQQ-like domain K05889 - 1.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000567 342.0
HKD2_k127_9630618_8 Putative esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 319.0
HKD2_k127_9630618_9 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000001049 259.0
HKD2_k127_9813053_0 The M ring may be actively involved in energy transduction K02409 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002552 437.0
HKD2_k127_9813053_1 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K10943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 440.0
HKD2_k127_9813053_2 sigma54 specific, transcriptional regulator, Fis family K10941 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003253 362.0
HKD2_k127_9813053_3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation K02410 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 342.0
HKD2_k127_9813053_4 Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end K02407 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 301.0
HKD2_k127_9813053_5 Histidine kinase K10942 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000002679 257.0
HKD2_k127_9813053_6 flagellar protein FliS K02422 - - 0.000000000000000000000000000001427 124.0
HKD2_k127_9813053_7 Flagellar hook-basal body complex protein FliE K02408 - - 0.00000000000000000009681 92.0
HKD2_k127_9813053_8 FlaG protein K06603 - - 0.00000003972 60.0
HKD2_k127_9818998_0 Cellulose biosynthesis protein BcsQ - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003989 254.0
HKD2_k127_9818998_1 CHAD domain containing protein - - - 0.000000000000000000000000000003669 134.0
HKD2_k127_9818998_2 EamA-like transporter family - - - 0.00006212 48.0