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Overview

ID MAG01790
Name HKD2_bin.32
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Desulfobacterota_E
Class Deferrimicrobia
Order Deferrimicrobiales
Family Deferrimicrobiaceae
Genus Deferrimicrobium
Species
Assembly information
Completeness (%) 69.64
Contamination (%) 0.38
GC content (%) 66.0
N50 (bp) 5,471
Genome size (bp) 1,610,549

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1646

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10007144_0 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003882 266.0
HKD2_k127_10007144_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0000000000000000000000000000000000000000000000000000004646 200.0
HKD2_k127_10007144_2 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000001982 137.0
HKD2_k127_10007144_3 PFAM NHL repeat containing protein K13735 - - 0.0000000000000002712 84.0
HKD2_k127_10079453_0 ABC transporter transmembrane region K06147,K18890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004535 503.0
HKD2_k127_10079453_1 ABC transporter transmembrane region K06147,K18889 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 299.0
HKD2_k127_10079453_2 ABC transporter, phosphonate, periplasmic substrate-binding protein K02044 - - 0.00000000000000000000000000009902 120.0
HKD2_k127_10102786_0 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 359.0
HKD2_k127_10102786_1 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.000000000000000000000000000000000000000003364 163.0
HKD2_k127_10102786_2 Cold-shock protein K03704 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0008150,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000001259 85.0
HKD2_k127_10136863_0 periplasmic glucan biosynthesis protein K03670 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007009 549.0
HKD2_k127_10136863_1 Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) K03669 GO:0005575,GO:0016020 - 0.00000000000000000000000000000000000000000000000000000000000005437 229.0
HKD2_k127_10136863_2 - - - - 0.000000000000000000000000000000001096 133.0
HKD2_k127_10136863_3 SMART Transport-associated and nodulation region K04065 - - 0.0000000000000000000001121 102.0
HKD2_k127_10136863_4 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000003254 102.0
HKD2_k127_10136863_5 deaminase K01485 - 3.5.4.1 0.00000000000001895 80.0
HKD2_k127_1020481_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 9.444e-204 641.0
HKD2_k127_1020481_1 Chase2 domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 504.0
HKD2_k127_1020481_2 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008849 454.0
HKD2_k127_1020481_3 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000009121 189.0
HKD2_k127_1020481_4 chlorophyll binding K03286 - - 0.00000000000000000000000000000000000009367 150.0
HKD2_k127_1020481_5 FecR protein - - - 0.0000000000000000000000000004328 119.0
HKD2_k127_1058110_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002164 610.0
HKD2_k127_1058110_1 PFAM iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000000000000000000003459 212.0
HKD2_k127_1069366_0 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 2.135e-225 709.0
HKD2_k127_1069366_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003898 627.0
HKD2_k127_1069366_2 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 332.0
HKD2_k127_1069366_3 PFAM cytochrome C oxidase mono-heme subunit FixO K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 315.0
HKD2_k127_1069366_4 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.00000000000000000000000000000000000000002648 161.0
HKD2_k127_1069366_5 PFAM cytochrome c, class I K00406 - - 0.000000000000000000000000000000002019 136.0
HKD2_k127_1069366_6 FixH - - - 0.000000000115 74.0
HKD2_k127_1069366_7 Cbb3-type cytochrome oxidase component FixQ - - - 0.0000000002805 62.0
HKD2_k127_1137199_0 PFAM Acetyl-CoA hydrolase transferase K01067 - 3.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004398 466.0
HKD2_k127_1137199_1 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K07788,K07789,K18138 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007733 456.0
HKD2_k127_1137199_2 Biotin-lipoyl like K07799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002928 357.0
HKD2_k127_1137199_3 NmrA-like family K00329,K00356 - 1.6.5.3,1.6.99.3 0.000000000000002344 84.0
HKD2_k127_118640_0 Asparagine synthase, glutamine-hydrolyzing K01953 - 6.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009274 421.0
HKD2_k127_118640_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000002004 195.0
HKD2_k127_118640_2 - - - - 0.00000000000000000000000000000000000000000000002376 183.0
HKD2_k127_118640_3 tRNA (guanine(37)-N(1))-methyltransferase activity - - - 0.00000002647 67.0
HKD2_k127_1198411_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 7.228e-239 747.0
HKD2_k127_1198411_1 adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins - - - 0.0000000000000000000000000000000000000000001294 172.0
HKD2_k127_1198411_2 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 0.000000000007843 67.0
HKD2_k127_1198411_3 CBS domain K04767 - - 0.00000007411 64.0
HKD2_k127_119910_0 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis - - - 0.000000000000000000000000000000000000000000000005301 182.0
HKD2_k127_119910_1 Pfam SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000007565 157.0
HKD2_k127_119910_2 Domain of unknown function (DUF3332) - - - 0.00000000000000000102 96.0
HKD2_k127_119910_3 Histidine kinase K07709,K13924 - 2.1.1.80,2.7.13.3,3.1.1.61 0.0000000000000348 83.0
HKD2_k127_1264437_0 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005176 509.0
HKD2_k127_1264437_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008603 495.0
HKD2_k127_1264437_2 ABC transporter substrate binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 386.0
HKD2_k127_1264437_3 ABC transporter substrate binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003999 373.0
HKD2_k127_1264437_4 Belongs to the bacterial solute-binding protein 3 family K02030,K10001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004484 287.0
HKD2_k127_1264437_5 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000009691 56.0
HKD2_k127_1280459_0 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01840,K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008473 535.0
HKD2_k127_1280459_1 malic enzyme K00027 - 1.1.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006553 313.0
HKD2_k127_1280459_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000007658 55.0
HKD2_k127_1309864_0 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 446.0
HKD2_k127_1309864_1 Bacterial regulatory protein, Fis family K13599 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 310.0
HKD2_k127_1309864_2 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway - - - 0.00000000000000000000000000000000000000001916 163.0
HKD2_k127_1312536_0 phosphoenolpyruvate carboxykinase (ATP) activity K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007699 531.0
HKD2_k127_1312536_1 Inhibitor of apoptosis-promoting Bax1 K06890,K19416 - - 0.000000000000000000000000000000000000000000000000000000000000000002168 235.0
HKD2_k127_1312536_2 ribosomal large subunit export from nucleus - - - 0.00000000000000000000000000000000000000000000001859 177.0
HKD2_k127_1312536_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000005784 168.0
HKD2_k127_1312536_4 ACT domain protein K00003,K00058,K01754,K04767 - 1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19 0.00000000000000000000000000000001052 145.0
HKD2_k127_1330192_0 Acetolactate synthase, large subunit K01652 - 2.2.1.6 1.077e-222 697.0
HKD2_k127_1330192_1 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000001186 226.0
HKD2_k127_1330192_2 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000001939 215.0
HKD2_k127_1330192_3 Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide K01725 - 4.2.1.104 0.00000000000000000000000000000000000000000000000000000006979 199.0
HKD2_k127_1330192_4 Class I peptide chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.0000000000000000000000000000000000000005307 156.0
HKD2_k127_1330192_5 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000002096 113.0
HKD2_k127_1344414_0 TIGRFAM phosphate ABC transporter K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 292.0
HKD2_k127_1344414_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000005025 184.0
HKD2_k127_1344414_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000002705 138.0
HKD2_k127_1392488_0 Peptidase family M50 K11749 - - 0.000000000000000000000000000000000000000000000000000000003185 205.0
HKD2_k127_1392488_1 Glycoprotease family - - - 0.000000000000000000000000000000000002264 147.0
HKD2_k127_1392488_2 Protein of unknown function (DUF465) K09794 - - 0.000000008589 59.0
HKD2_k127_1402510_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 436.0
HKD2_k127_1402510_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 351.0
HKD2_k127_1402510_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K05580 - 1.6.5.3 0.0000000000000000007023 90.0
HKD2_k127_1406145_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 609.0
HKD2_k127_1406145_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003358 588.0
HKD2_k127_1406145_10 Mur ligase family, catalytic domain K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004709 304.0
HKD2_k127_1406145_11 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004528 300.0
HKD2_k127_1406145_12 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000145 266.0
HKD2_k127_1406145_13 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000004268 259.0
HKD2_k127_1406145_14 Belongs to the GTP cyclohydrolase I type 2 NIF3 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002466 248.0
HKD2_k127_1406145_15 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000009832 232.0
HKD2_k127_1406145_16 Cell wall formation K00075 - 1.3.1.98 0.0000000000000000000000000000000000000000000000000004069 196.0
HKD2_k127_1406145_17 C4-type zinc ribbon domain K07164 - - 0.00000000000000000000000000000000000003309 153.0
HKD2_k127_1406145_18 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000002487 148.0
HKD2_k127_1406145_19 PFAM Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000002749 143.0
HKD2_k127_1406145_2 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 K01000 - 2.7.8.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 505.0
HKD2_k127_1406145_20 Phosphoribosyl-AMP cyclohydrolase K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000001526 142.0
HKD2_k127_1406145_21 Yqey-like protein K09117 - - 0.0000000000000000000000000000000003306 136.0
HKD2_k127_1406145_22 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.000000000000000000000000000000003868 133.0
HKD2_k127_1406145_23 Ribonuclease H K03469 - 3.1.26.4 0.0000000000000000000000000000001934 138.0
HKD2_k127_1406145_24 Essential cell division protein K03589 - - 0.000000000000000000000000004033 121.0
HKD2_k127_1406145_25 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000004156 103.0
HKD2_k127_1406145_26 - - - - 0.00000000000003962 78.0
HKD2_k127_1406145_27 Cell division protein FtsL - - - 0.000001176 56.0
HKD2_k127_1406145_28 - - - - 0.0002425 44.0
HKD2_k127_1406145_3 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 508.0
HKD2_k127_1406145_4 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004079 452.0
HKD2_k127_1406145_5 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 419.0
HKD2_k127_1406145_6 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004241 390.0
HKD2_k127_1406145_7 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005878 410.0
HKD2_k127_1406145_8 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006325 352.0
HKD2_k127_1406145_9 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006654 337.0
HKD2_k127_1424985_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 5.998e-272 848.0
HKD2_k127_1424985_1 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 364.0
HKD2_k127_1424985_2 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 350.0
HKD2_k127_1424985_3 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 346.0
HKD2_k127_1424985_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000007278 237.0
HKD2_k127_1424985_5 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000005743 230.0
HKD2_k127_1424985_6 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000005983 223.0
HKD2_k127_1424985_7 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000003899 209.0
HKD2_k127_1435011_0 PFAM FAD linked oxidase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004102 511.0
HKD2_k127_1435011_1 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001688 256.0
HKD2_k127_1435011_2 Di-haem cytochrome c peroxidase - - - 0.000000000000000000000000000000000000000000000001883 175.0
HKD2_k127_1435011_3 DoxX family K15977 - - 0.0000000000000000000000000007974 121.0
HKD2_k127_1435011_4 protein conserved in bacteria - - - 0.00000000008852 65.0
HKD2_k127_1436004_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 392.0
HKD2_k127_1436004_1 type IV pilus secretin PilQ K02666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001805 286.0
HKD2_k127_1436004_2 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000000000001664 138.0
HKD2_k127_1445257_0 Belongs to the peptidase M16 family K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 392.0
HKD2_k127_1472120_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005077 359.0
HKD2_k127_1472120_1 PUA domain K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 317.0
HKD2_k127_1472120_2 Ribosomal L27 protein K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000005428 135.0
HKD2_k127_1472120_3 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.00000000000000000000000000004873 119.0
HKD2_k127_1472120_4 N,N-dimethylaniline monooxygenase activity K07222 - - 0.0000000000000001689 88.0
HKD2_k127_1478965_0 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 434.0
HKD2_k127_1478965_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004521 374.0
HKD2_k127_1478965_2 dienelactone hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005202 335.0
HKD2_k127_1478965_3 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008983 316.0
HKD2_k127_1478965_4 PFAM ABC transporter related K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006635 310.0
HKD2_k127_1478965_5 ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001775 270.0
HKD2_k127_1478965_6 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.00000000000000000000000000000000003476 140.0
HKD2_k127_1478965_7 NUDIX domain K03575 - - 0.00001436 49.0
HKD2_k127_1493276_0 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006262 522.0
HKD2_k127_1493276_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006919 505.0
HKD2_k127_1493276_10 FecR protein - - - 0.00000000000000000000000000000157 127.0
HKD2_k127_1493276_11 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage - - - 0.0000000000000000676 88.0
HKD2_k127_1493276_12 - - - - 0.0000000000000002453 83.0
HKD2_k127_1493276_13 PFAM Uncharacterised protein family UPF0150 - - - 0.000000000002456 72.0
HKD2_k127_1493276_14 - - - - 0.0000000002232 74.0
HKD2_k127_1493276_15 Bacterial regulatory protein, Fis family K10126 - - 0.0000000005575 66.0
HKD2_k127_1493276_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002628 510.0
HKD2_k127_1493276_3 DNA replication proofreading K02336,K06877 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 452.0
HKD2_k127_1493276_4 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 311.0
HKD2_k127_1493276_5 Methylpurine-DNA glycosylase (MPG) K03652 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006004 267.0
HKD2_k127_1493276_6 PBP superfamily domain K02040 - - 0.0000000000000000000000000000000000000000000000000000002262 205.0
HKD2_k127_1493276_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000002873 216.0
HKD2_k127_1493276_8 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000003396 171.0
HKD2_k127_1493276_9 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000002896 156.0
HKD2_k127_1496626_0 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000003817 244.0
HKD2_k127_1496626_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.00000000000000000000000000000000000000713 160.0
HKD2_k127_1496626_2 PFAM Peptidase M23 - - - 0.00000000000000000000000000001312 120.0
HKD2_k127_1496626_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000003655 72.0
HKD2_k127_1535490_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001365 273.0
HKD2_k127_1535490_1 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.0000000000000005097 91.0
HKD2_k127_155520_0 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004729 462.0
HKD2_k127_155520_1 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 377.0
HKD2_k127_155520_2 Ferritin-like domain K03594 - 1.16.3.1 0.00000000000000000000000000000000000000000000000000000001105 201.0
HKD2_k127_155520_3 Rhodanese Homology Domain - - - 0.000000000000000000000000001286 116.0
HKD2_k127_155520_4 PFAM Phosphoglycerate mutase K08296 - - 0.000000000000000000000007367 116.0
HKD2_k127_156252_0 - - - - 0.000000000000000000000002387 105.0
HKD2_k127_156252_1 Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system K02071 - - 0.00000001272 66.0
HKD2_k127_156252_2 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0002798 43.0
HKD2_k127_156252_3 Belongs to the ABC-4 integral membrane protein family. FtsX subfamily K09811,K09812 GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0040011,GO:0042173,GO:0042221,GO:0043207,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0071976,GO:0090529,GO:1902531 - 0.0007426 51.0
HKD2_k127_1579251_0 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 342.0
HKD2_k127_1592963_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001818 267.0
HKD2_k127_1592963_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000000002567 221.0
HKD2_k127_1592963_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.000000000000000000000000000009187 126.0
HKD2_k127_1656741_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 565.0
HKD2_k127_1656741_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000001609 221.0
HKD2_k127_1671958_0 Proposed homoserine kinase K15635 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 435.0
HKD2_k127_1671958_1 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174,K00186 - 1.2.7.11,1.2.7.3,1.2.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005968 421.0
HKD2_k127_1671958_2 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 413.0
HKD2_k127_1671958_3 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 372.0
HKD2_k127_1671958_4 PFAM pyruvate ferredoxin flavodoxin oxidoreductase K00177 - 1.2.7.3 0.000000000000000000000000000000000000000000000000000001478 199.0
HKD2_k127_1671958_5 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000004457 155.0
HKD2_k127_1671958_6 Thioesterase-like superfamily K07107 - - 0.00000000000000000000000000000009732 136.0
HKD2_k127_1671958_7 4 iron, 4 sulfur cluster binding K00176 - 1.2.7.3 0.0000000000000000007337 87.0
HKD2_k127_1757137_0 MlaD protein K06192 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003241 307.0
HKD2_k127_1757137_1 ABC-type transport auxiliary lipoprotein component - - - 0.0000000000000000000000000000000000000000000000000000001086 205.0
HKD2_k127_1757137_3 - - - - 0.000000000000000297 89.0
HKD2_k127_1793704_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679,K01744 - 4.2.1.2,4.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 530.0
HKD2_k127_1793704_1 PFAM Cytochrome c oxidase, subunit I K04561 - 1.7.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 477.0
HKD2_k127_1793704_2 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 338.0
HKD2_k127_1793704_3 Domains Cache_1, HAMP, PAS, PAS K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000603 270.0
HKD2_k127_1793704_4 cytochrome c K02305 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000816 224.0
HKD2_k127_1793704_5 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000002156 202.0
HKD2_k127_1793704_6 membrane-bound metal-dependent K07038 - - 0.000000000000000000000000008597 123.0
HKD2_k127_1796922_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 7.991e-262 831.0
HKD2_k127_1796922_1 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 293.0
HKD2_k127_1796922_2 - - - - 0.0000000000000000000000000000000000000000000000003482 179.0
HKD2_k127_1796922_3 RNA-binding - - - 0.0000000000000000000000000000006629 124.0
HKD2_k127_1796922_4 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.00000000000000000189 89.0
HKD2_k127_1796922_5 Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex K03594 - 1.16.3.1 0.000000000000000002161 97.0
HKD2_k127_181988_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 8.133e-252 793.0
HKD2_k127_181988_1 Protein of unknown function (DUF512) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005636 365.0
HKD2_k127_181988_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - 0.00000000000000000000000000000000000000000000004976 192.0
HKD2_k127_181988_3 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.00000000000000000000000000000000000000181 150.0
HKD2_k127_181988_4 Ribosomal protein L35 K02916 - - 0.0000000000002151 71.0
HKD2_k127_1904104_0 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 370.0
HKD2_k127_1904104_1 Domain of unknown function (DUF2088) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 355.0
HKD2_k127_1904104_10 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001376 267.0
HKD2_k127_1904104_11 PFAM Glycosyl transferase, group 1 K02844 - - 0.00000000000000000000000000000000000000000000000000000000166 220.0
HKD2_k127_1904104_12 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000007014 200.0
HKD2_k127_1904104_13 Glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000002338 160.0
HKD2_k127_1904104_14 Uncharacterized protein conserved in bacteria (DUF2155) - - - 0.000000000000000000000000000000000003163 144.0
HKD2_k127_1904104_15 PFAM Cupin 2 conserved barrel domain protein - - - 0.0000000000000000000000001516 111.0
HKD2_k127_1904104_2 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006056 365.0
HKD2_k127_1904104_3 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K16787 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 338.0
HKD2_k127_1904104_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005767 312.0
HKD2_k127_1904104_5 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 299.0
HKD2_k127_1904104_6 Cobalt transport protein K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002185 276.0
HKD2_k127_1904104_7 PFAM glycosyl transferase, family 9 K02849 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009003 276.0
HKD2_k127_1904104_8 PFAM inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000001185 286.0
HKD2_k127_1904104_9 PFAM glycosyl transferase family 9 K02841 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007177 274.0
HKD2_k127_1945579_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009952 302.0
HKD2_k127_1945579_1 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003251 274.0
HKD2_k127_1966141_0 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K11779,K11784,K18285 - 1.21.98.1,2.5.1.120,2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002678 451.0
HKD2_k127_1966141_1 Histidine kinase K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000001676 198.0
HKD2_k127_205409_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 8.912e-206 649.0
HKD2_k127_205409_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008767 606.0
HKD2_k127_205409_10 Thymidylate synthase complementing protein K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004222 270.0
HKD2_k127_205409_11 Protein of unknown function (DUF1385) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001265 273.0
HKD2_k127_205409_12 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000007439 267.0
HKD2_k127_205409_13 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000001399 259.0
HKD2_k127_205409_14 Permease YjgP YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000005986 209.0
HKD2_k127_205409_15 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.0000000000000000000000000000000000000000000000007387 185.0
HKD2_k127_205409_16 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.00000000000000000000000000000000000000000000242 169.0
HKD2_k127_205409_17 PFAM permease YjgP YjgQ family protein K07091 - - 0.00000000000000000000000000000000000000005165 166.0
HKD2_k127_205409_18 PFAM PTS system mannose fructose sorbose family IID component K02796 - - 0.000000000000000000000000000000001369 144.0
HKD2_k127_205409_19 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.000000000000000000000000000001143 130.0
HKD2_k127_205409_2 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 568.0
HKD2_k127_205409_20 PTS system sorbose subfamily IIB component K02794 - 2.7.1.191 0.0000000000000000000000000008804 118.0
HKD2_k127_205409_21 PTS system fructose IIA component K02793 - 2.7.1.191 0.0000000000000000000000000009139 119.0
HKD2_k127_205409_22 - - - - 0.000000000000000000000002389 105.0
HKD2_k127_205409_23 50S ribosomal protein L31 K02909 - - 0.00000000000000000000004119 108.0
HKD2_k127_205409_24 PTS HPr component phosphorylation site K11189 - - 0.00000000000000000000009165 103.0
HKD2_k127_205409_25 PTS system sorbose-specific iic component K02795 - - 0.0000000000000000004308 96.0
HKD2_k127_205409_3 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 523.0
HKD2_k127_205409_4 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004257 473.0
HKD2_k127_205409_5 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 435.0
HKD2_k127_205409_6 PFAM peptidase S1 and S6, chymotrypsin Hap K04771,K04772 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 354.0
HKD2_k127_205409_7 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005644 282.0
HKD2_k127_205409_8 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003419 279.0
HKD2_k127_205409_9 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009399 279.0
HKD2_k127_2144254_0 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005016 395.0
HKD2_k127_2144254_1 PFAM SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003489 392.0
HKD2_k127_2144254_2 Cytochrome c7 and related cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001904 288.0
HKD2_k127_2144254_3 Biotin carboxylase C-terminal domain K01941,K11263 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 6.3.4.14,6.3.4.6,6.4.1.2,6.4.1.3 0.0000000000000000000000000000000000000000002276 162.0
HKD2_k127_2151532_0 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000807 595.0
HKD2_k127_2151532_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003416 246.0
HKD2_k127_2151532_2 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000002538 232.0
HKD2_k127_2151532_3 - - - - 0.0000000000000000000000000000000000000000001281 165.0
HKD2_k127_2212593_0 PFAM Type II secretion system protein E K02454 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008553 437.0
HKD2_k127_2212593_1 General secretion pathway protein F K02455,K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003251 288.0
HKD2_k127_2212593_2 Type II secretion system (T2SS), protein G K02456 - - 0.0000000000000000000000000000000000000000000000000003298 192.0
HKD2_k127_2212593_3 PFAM General secretion pathway protein K K02460 - - 0.00000000000000000000000000000006095 137.0
HKD2_k127_2212593_4 Type II secretion system (T2SS), protein J K02459 - - 0.00000000000000002198 92.0
HKD2_k127_2212593_5 General secretion pathway protein I K02458 - - 0.000002015 55.0
HKD2_k127_2214316_0 Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 4.64e-224 707.0
HKD2_k127_2214316_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.000000000000000000000000000000000000000000000004754 175.0
HKD2_k127_2234826_0 Elongation factor Tu domain 2 K02355 - - 1.877e-231 736.0
HKD2_k127_2234826_1 ADP-ribosylation factor family K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000148 256.0
HKD2_k127_2234826_2 - - - - 0.0000000000000004471 93.0
HKD2_k127_227398_0 Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 412.0
HKD2_k127_227398_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 336.0
HKD2_k127_227398_2 Cytochrome c3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002906 289.0
HKD2_k127_227398_3 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000000000000003588 213.0
HKD2_k127_227398_4 metalloendopeptidase activity K03799 - - 0.000000000000000000000002769 115.0
HKD2_k127_227398_5 Class III cytochrome C family - GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.0000000003943 68.0
HKD2_k127_229480_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K07138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 418.0
HKD2_k127_229480_1 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003821 285.0
HKD2_k127_229480_2 PFAM ATPase, BadF BadG BcrA BcrD type - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004669 263.0
HKD2_k127_229480_3 Transcriptional regulator, CarD family K07736 - - 0.00000000000000000000000000000000000000000000000007157 184.0
HKD2_k127_229480_4 PFAM aminotransferase class V - - - 0.000000000000000000000001142 107.0
HKD2_k127_229480_5 Belongs to the class-I aminoacyl-tRNA synthetase family K01883,K15526 GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 6.1.1.16,6.3.1.13 0.000008723 58.0
HKD2_k127_229677_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008055 515.0
HKD2_k127_229677_1 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 369.0
HKD2_k127_229677_2 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 288.0
HKD2_k127_229677_3 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004066 289.0
HKD2_k127_229677_4 Domain of unknown function (DUF2437) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001006 284.0
HKD2_k127_229677_5 regulatory protein IclR - - - 0.0000000000000000000000000000000000000000000000000000000000000000005131 234.0
HKD2_k127_229677_6 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950,K13940 - 2.7.6.3,4.1.2.25 0.000000000000000000000000005133 116.0
HKD2_k127_229677_7 Tetratricopeptide TPR_2 repeat protein - - - 0.0000000000000000000000001931 113.0
HKD2_k127_2304441_0 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 543.0
HKD2_k127_2304441_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000008406 108.0
HKD2_k127_2304441_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 0.00000000000000003745 81.0
HKD2_k127_2304441_3 Modulates RecA activity K03565 - - 0.000000001545 66.0
HKD2_k127_2357841_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.0 1013.0
HKD2_k127_2357841_1 response regulator - - - 0.0000000000000000000000002556 119.0
HKD2_k127_2398344_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 4.803e-209 664.0
HKD2_k127_2398344_1 - - - - 0.0000000000000000000000000000000003135 138.0
HKD2_k127_2398344_2 ATPase P-type (Transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000000000000003246 85.0
HKD2_k127_2457169_0 PFAM ROSMUCR transcriptional regulator - - - 0.0000000000000000000000000004471 118.0
HKD2_k127_2457169_1 4-oxalocrotonate tautomerase K01821 - 5.3.2.6 0.0000000000000000000000003461 113.0
HKD2_k127_2457169_2 PFAM Phosphoglycerate mutase K08296 - - 0.00000000000000001751 87.0
HKD2_k127_2457169_3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000001076 59.0
HKD2_k127_2485009_0 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000012 291.0
HKD2_k127_2485009_1 phosphinothricin N-acetyltransferase activity - - - 0.00000000000000000000000000000000000002086 150.0
HKD2_k127_2485009_2 PFAM AMP-dependent synthetase and ligase - - - 0.000004126 54.0
HKD2_k127_2510493_0 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - 2.56e-197 627.0
HKD2_k127_2510493_1 Aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 462.0
HKD2_k127_2510493_2 Mechanosensitive ion channel K03442 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008746 318.0
HKD2_k127_2510493_3 Putative regulatory protein - - - 0.00000007713 60.0
HKD2_k127_2561573_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.111e-306 952.0
HKD2_k127_2561573_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 608.0
HKD2_k127_2561573_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000001413 125.0
HKD2_k127_2589617_0 TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008765 339.0
HKD2_k127_2589617_1 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000006085 234.0
HKD2_k127_2589617_2 Aldo/keto reductase family - - - 0.0000000000000000000000000006076 116.0
HKD2_k127_2596964_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 8.106e-247 778.0
HKD2_k127_2596964_1 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 5.989e-242 755.0
HKD2_k127_2596964_10 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000001497 143.0
HKD2_k127_2596964_11 Cupin 2 conserved barrel domain - - - 0.000000000000000000000007612 105.0
HKD2_k127_2596964_12 SpoVT / AbrB like domain - - - 0.00000000000000000000003572 104.0
HKD2_k127_2596964_13 Putative zinc-finger - - - 0.00000000000751 70.0
HKD2_k127_2596964_14 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.00000004705 55.0
HKD2_k127_2596964_2 PFAM CO dehydrogenase acetyl-CoA synthase delta subunit, TIM barrel K00197 - 2.1.1.245 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005419 402.0
HKD2_k127_2596964_3 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005273 396.0
HKD2_k127_2596964_4 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003765 372.0
HKD2_k127_2596964_5 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 303.0
HKD2_k127_2596964_6 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000005089 261.0
HKD2_k127_2596964_7 PFAM SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000004677 254.0
HKD2_k127_2596964_8 Peptide methionine sulfoxide reductase K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000009666 224.0
HKD2_k127_2596964_9 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000000000004243 184.0
HKD2_k127_2607638_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005597 443.0
HKD2_k127_2607638_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000005049 238.0
HKD2_k127_2607638_2 PFAM Aldo keto reductase family - - - 0.00000000000000000000000000000000000000008322 164.0
HKD2_k127_2633743_0 Glycosyltransferase family 20 K00697,K13057,K20436 - 2.4.1.15,2.4.1.245,2.4.1.347,2.5.1.135 0.0 1086.0
HKD2_k127_2633743_1 Chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 303.0
HKD2_k127_2633743_2 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000000000002892 175.0
HKD2_k127_2633743_3 trehalose biosynthetic process K01087 - 3.1.3.12 0.000000000000000000000000000000000000000001263 180.0
HKD2_k127_2660022_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000242 609.0
HKD2_k127_2660022_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003989 435.0
HKD2_k127_2660022_10 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000000004157 225.0
HKD2_k127_2660022_11 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000003955 208.0
HKD2_k127_2660022_12 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000001252 205.0
HKD2_k127_2660022_13 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000001428 199.0
HKD2_k127_2660022_14 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000002881 203.0
HKD2_k127_2660022_15 Binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000000000002627 181.0
HKD2_k127_2660022_16 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000008401 177.0
HKD2_k127_2660022_17 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.000000000000000000000000000000000000000000001453 169.0
HKD2_k127_2660022_18 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000003906 147.0
HKD2_k127_2660022_19 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000401 151.0
HKD2_k127_2660022_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 400.0
HKD2_k127_2660022_20 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000004593 141.0
HKD2_k127_2660022_21 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000007174 140.0
HKD2_k127_2660022_22 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.000000000000000000000000000000000008605 137.0
HKD2_k127_2660022_23 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000005102 138.0
HKD2_k127_2660022_24 Ribosomal protein L17 K02879 - - 0.000000000000000000000000000000002429 136.0
HKD2_k127_2660022_25 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000003541 125.0
HKD2_k127_2660022_26 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000004885 113.0
HKD2_k127_2660022_27 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000002361 111.0
HKD2_k127_2660022_28 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000000002159 106.0
HKD2_k127_2660022_29 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000002086 113.0
HKD2_k127_2660022_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 316.0
HKD2_k127_2660022_30 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.000000000000000001031 90.0
HKD2_k127_2660022_31 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000000002978 73.0
HKD2_k127_2660022_32 Ribosomal protein L30 K02907 - - 0.0000000006575 67.0
HKD2_k127_2660022_33 Belongs to the universal ribosomal protein uL29 family K02904 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000008033 55.0
HKD2_k127_2660022_4 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 307.0
HKD2_k127_2660022_5 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007219 302.0
HKD2_k127_2660022_6 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000478 289.0
HKD2_k127_2660022_7 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002914 270.0
HKD2_k127_2660022_8 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003315 265.0
HKD2_k127_2660022_9 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000000000000000000000000000000000000000000000000000006488 228.0
HKD2_k127_2665056_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 577.0
HKD2_k127_2665056_1 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000498 282.0
HKD2_k127_2665056_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.0000000000000000000000000000000000000000000000000000001577 206.0
HKD2_k127_2665056_3 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15,2.7.6.3 0.000000000000000000000000000001136 124.0
HKD2_k127_2665056_4 YbbR-like protein - - - 0.000000000000000000001533 105.0
HKD2_k127_2668183_0 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738,K01883,K12339 - 2.5.1.47,6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007135 439.0
HKD2_k127_2668183_1 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481,K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003033 408.0
HKD2_k127_2668183_2 nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006656 322.0
HKD2_k127_2668183_3 ABC transporter K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008806 299.0
HKD2_k127_2668183_4 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000002776 270.0
HKD2_k127_2668183_5 Extracellular solute-binding protein K02048 - - 0.0000000000000000000000000000000000000000000000000000000000006574 223.0
HKD2_k127_2668183_6 TIGRFAM sulfate ABC transporter K02046 - - 0.00000000000000000000000000000000000000000000000000000000082 211.0
HKD2_k127_2683501_0 MMPL family K07003 - - 0.0 1100.0
HKD2_k127_2683501_1 Protein of unknown function (DUF1329) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004961 546.0
HKD2_k127_2683501_2 Protein of unknown function (DUF1302) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 547.0
HKD2_k127_2683501_3 ABC transporter transmembrane region K06147 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006807 356.0
HKD2_k127_2683501_4 Peptidase family U32 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007414 292.0
HKD2_k127_2683501_5 Subtilase family - - - 0.0000000000000000000000000000001964 133.0
HKD2_k127_2683501_6 peptidase U32 - - - 0.000000000000000000000000000001176 132.0
HKD2_k127_2687612_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 329.0
HKD2_k127_2687612_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0006811 46.0
HKD2_k127_2689721_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11383 - 2.7.13.3 2.503e-212 676.0
HKD2_k127_2689721_1 PFAM response regulator receiver K11384 - - 8.838e-201 634.0
HKD2_k127_2689721_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 576.0
HKD2_k127_2689721_3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.000000000000000000000000000000007448 135.0
HKD2_k127_2697106_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 1.874e-273 863.0
HKD2_k127_2697106_1 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006819 497.0
HKD2_k127_2697106_2 Outer membrane protein beta-barrel domain - - - 0.000000000000000000000000000000000001211 155.0
HKD2_k127_2697106_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000001421 144.0
HKD2_k127_2697106_4 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000005559 68.0
HKD2_k127_2697106_5 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000007651 78.0
HKD2_k127_2702210_0 nitrogen compound transport K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 322.0
HKD2_k127_2702210_1 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 312.0
HKD2_k127_2702210_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000056 279.0
HKD2_k127_2702210_3 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000004005 269.0
HKD2_k127_2702210_4 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000001131 190.0
HKD2_k127_2702210_5 transglycosylase K08309 - - 0.00000000000000000000000000002728 136.0
HKD2_k127_2702210_6 Xylose isomerase-like TIM barrel - - - 0.00000000000000000000003035 110.0
HKD2_k127_2714061_0 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007511 511.0
HKD2_k127_2714061_1 NMT1-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002799 374.0
HKD2_k127_2714061_2 Outer membrane protein beta-barrel domain - - - 0.00000000000000000000000001962 119.0
HKD2_k127_2714061_3 AsmA-like C-terminal region - - - 0.000000000001938 68.0
HKD2_k127_2722394_0 NADH-quinone oxidoreductase chain L K00341 - 1.6.5.3 2.436e-197 638.0
HKD2_k127_2722394_1 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 593.0
HKD2_k127_2722394_2 ATP synthesis coupled electron transport K00340,K05576 - 1.6.5.3 0.0000000000000000000003014 98.0
HKD2_k127_2747336_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 603.0
HKD2_k127_2747336_1 type II secretion system protein E K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003878 514.0
HKD2_k127_2747336_2 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004272 378.0
HKD2_k127_2747336_3 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000001911 172.0
HKD2_k127_2747336_4 Belongs to the binding-protein-dependent transport system permease family K02031 - - 0.00000000000000001034 86.0
HKD2_k127_2747336_5 - - - - 0.0000000001311 63.0
HKD2_k127_2749576_0 Branched-chain amino acid transport system / permease component K01997,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 436.0
HKD2_k127_2749576_1 extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006663 282.0
HKD2_k127_2749576_2 COG0411 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.00000000000000000000000000000000000000000000000000000000000002856 243.0
HKD2_k127_2749576_3 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000004717 205.0
HKD2_k127_2749576_4 MaoC like domain K17865 - 4.2.1.55 0.00000000000000000000000000000000000000000001938 167.0
HKD2_k127_2749576_5 PFAM Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000001832 154.0
HKD2_k127_275251_0 PFAM glycosyl transferase family 39 K07264 - 2.4.2.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 374.0
HKD2_k127_275251_1 Belongs to the DegT DnrJ EryC1 family K07806 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0008483,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:0099620,GO:1901363 2.6.1.87 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003391 274.0
HKD2_k127_275251_2 Cytochrome P460 - - - 0.0000000000000000000000000000000000000000000000000000002045 201.0
HKD2_k127_276860_0 NapC/NirT cytochrome c family, N-terminal region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 450.0
HKD2_k127_276860_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 400.0
HKD2_k127_276860_2 hydrolase activity, acting on ester bonds K01055 - 3.1.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 385.0
HKD2_k127_276860_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000003259 226.0
HKD2_k127_276860_4 Protein of unknown function (DUF1254) - - - 0.000000000000000000000000000000000000000000000000000000002603 202.0
HKD2_k127_2786693_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.591e-196 632.0
HKD2_k127_2786693_1 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 496.0
HKD2_k127_2786693_2 Necessary for formate dehydrogenase activity K02380 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 351.0
HKD2_k127_2786693_3 Prokaryotic cytochrome b561 K00127 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009094 248.0
HKD2_k127_2786693_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000004238 231.0
HKD2_k127_2786693_5 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000002374 210.0
HKD2_k127_2786693_6 Protein of unknown function (DUF3467) - - - 0.0000000000000000000000000001088 119.0
HKD2_k127_2804518_0 1,4-alpha-glucan branching enzyme activity K00700,K01236 GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576 2.4.1.18,3.2.1.141 2.134e-321 998.0
HKD2_k127_2804518_1 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009943 306.0
HKD2_k127_2804518_2 domain protein - - - 0.000000000000000000000000000000001371 139.0
HKD2_k127_2804518_3 - - - - 0.00000000000000000000000000000001645 136.0
HKD2_k127_2809908_0 Receptor family ligand binding region K01999 - - 6.541e-201 651.0
HKD2_k127_2809908_1 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004164 412.0
HKD2_k127_2809908_2 Branched-chain amino acid transport system / permease component K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 387.0
HKD2_k127_2809908_3 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 362.0
HKD2_k127_2809908_4 Dehydrogenase E1 component K00161,K00166 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 356.0
HKD2_k127_2809908_5 amino acid K01995 - - 0.000000000000000000000000000003624 135.0
HKD2_k127_2809908_6 Transketolase, pyrimidine binding domain K00162,K00167 - 1.2.4.1,1.2.4.4 0.0000000000000004765 78.0
HKD2_k127_281896_0 PFAM Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001681 424.0
HKD2_k127_281896_1 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000005148 180.0
HKD2_k127_281896_2 - - - - 0.000000000000000000000000000000002487 133.0
HKD2_k127_281896_3 PFAM Metallophosphoesterase K07098 - - 0.0000000000000000026 85.0
HKD2_k127_283870_0 ABC transporter K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000047 633.0
HKD2_k127_283870_1 PFAM Thiamine pyrophosphate K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000239 261.0
HKD2_k127_283870_2 3-deoxy-7-phosphoheptulonate synthase activity - - - 0.000000000000000000007423 92.0
HKD2_k127_283870_3 - - - - 0.000004384 53.0
HKD2_k127_2861112_0 Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000008357 235.0
HKD2_k127_2861112_1 Glycine cleavage H-protein - - - 0.00000000000000000000000000000000000000000003533 171.0
HKD2_k127_2894460_0 COG0500 SAM-dependent methyltransferases K09846 - 2.1.1.210 0.00000000000000000000000000000000000000000000000000000000001364 221.0
HKD2_k127_2894460_1 AMP binding - - - 0.000000000002406 78.0
HKD2_k127_2894460_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000003485 72.0
HKD2_k127_292263_0 Pyruvate kinase, barrel domain K00873 - 2.7.1.40 1.063e-198 642.0
HKD2_k127_292263_1 nitric oxide reductase activity K22405 - 1.6.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006149 565.0
HKD2_k127_292263_10 PFAM Phosphoglycerate mutase K08296 - - 0.00000000000000000000000000000004947 130.0
HKD2_k127_292263_11 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.000000000000000000000006397 101.0
HKD2_k127_292263_12 CHAD domain - - - 0.0000002392 61.0
HKD2_k127_292263_14 Enoyl-(Acyl carrier protein) reductase - - - 0.00006949 48.0
HKD2_k127_292263_2 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000875 429.0
HKD2_k127_292263_3 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 347.0
HKD2_k127_292263_4 dTDP biosynthetic process K00560,K00943,K01585 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.1.1.45,2.7.4.9,4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 300.0
HKD2_k127_292263_5 dTDP biosynthetic process K00943,K01585 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.9,4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000002598 255.0
HKD2_k127_292263_6 ATP corrinoid adenosyltransferase K19221 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000177 206.0
HKD2_k127_292263_7 Cellulose biosynthesis protein BcsQ K03496 - - 0.00000000000000000000000000000000000000000000000000000377 199.0
HKD2_k127_292263_8 Protein of unknown function DUF47 K02039,K07220 GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000000000000000000000000002344 188.0
HKD2_k127_292263_9 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000002149 172.0
HKD2_k127_2954636_0 Branched-chain amino acid aminotransferase K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003325 422.0
HKD2_k127_2954636_1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase K03772,K03773 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008728 270.0
HKD2_k127_2954636_2 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000002533 219.0
HKD2_k127_2954636_3 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000002049 214.0
HKD2_k127_2954636_4 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000007703 174.0
HKD2_k127_2954636_5 TIGRFAM maf protein K06287 - - 0.00000000000000000000000000000000000000000000436 171.0
HKD2_k127_2954636_6 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000007986 159.0
HKD2_k127_2954636_7 YGGT family K02221 - - 0.00000000000000000000000000001255 121.0
HKD2_k127_2954636_8 Belongs to the UPF0235 family K09131 - - 0.000000000000000002117 92.0
HKD2_k127_2980752_0 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.000000000000000000000000000000000000008283 164.0
HKD2_k127_3006739_0 diguanylate cyclase - - - 0.00000000000000000000000000000000000000001067 177.0
HKD2_k127_3034698_0 3-beta hydroxysteroid dehydrogenase/isomerase family K10011,K12449 - 1.1.1.305,2.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 472.0
HKD2_k127_3034698_1 PFAM 2-nitropropane dioxygenase NPD K00459,K02371 - 1.13.12.16,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 434.0
HKD2_k127_3034698_2 Iron/manganese superoxide dismutases, C-terminal domain K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 316.0
HKD2_k127_3034698_3 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000006694 268.0
HKD2_k127_3034698_4 Formyl transferase, C-terminal domain K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000007208 235.0
HKD2_k127_3034698_5 Signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000001052 243.0
HKD2_k127_3034698_6 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000004507 221.0
HKD2_k127_3034698_7 PFAM ROSMUCR transcriptional regulator - - - 0.0000000000000000000000000000001673 129.0
HKD2_k127_303726_0 iron-sulfur cluster assembly K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000721 336.0
HKD2_k127_303726_1 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000001316 250.0
HKD2_k127_3093799_0 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.000000000000000000000000000000000000000007201 162.0
HKD2_k127_3169188_0 Bacterial DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002836 539.0
HKD2_k127_3169188_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001574 293.0
HKD2_k127_3169188_2 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.00000000000007384 84.0
HKD2_k127_3169518_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013,K15509 - 1.1.1.23,1.1.1.308 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 304.0
HKD2_k127_3169518_1 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000001135 254.0
HKD2_k127_3171642_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003476 549.0
HKD2_k127_3171642_1 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 297.0
HKD2_k127_3171642_2 COG0767 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004443 277.0
HKD2_k127_3171642_3 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006796 283.0
HKD2_k127_3171642_4 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.00000000000000000000000000000000000000000000000000006361 195.0
HKD2_k127_3171642_5 Belongs to the 'phage' integrase family - - - 0.00000000000000009603 82.0
HKD2_k127_3171642_6 Colicin V production protein K03558 - - 0.00000001443 63.0
HKD2_k127_3176661_0 AcrB/AcrD/AcrF family K03296 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005199 392.0
HKD2_k127_3176661_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002118 281.0
HKD2_k127_3176661_2 sigma factor activity K02405,K03093 - - 0.0000000000000000000000000000000000000000000000000000007888 203.0
HKD2_k127_3176661_3 Flagellar biogenesis master sigma-54-dependent transcriptional response regulator - - - 0.000000000000000000000000000000000000000000000000008372 185.0
HKD2_k127_3183779_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 535.0
HKD2_k127_3183779_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648,K18003 - 2.3.1.180,2.3.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 415.0
HKD2_k127_3183779_2 PFAM phosphoesterase, RecJ domain protein K07462 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003086 404.0
HKD2_k127_3183779_3 P-P-bond-hydrolysis-driven protein transmembrane transporter activity K03072,K03074,K12257 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000357 297.0
HKD2_k127_3183779_4 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000001279 263.0
HKD2_k127_3183779_5 Arginase family K01480 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000004403 260.0
HKD2_k127_3183779_6 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.0000000000000000000000000000000008703 135.0
HKD2_k127_3207903_0 Sigma-54 interaction domain K21405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 346.0
HKD2_k127_3207903_1 Protein involved in outer membrane biogenesis - - - 0.00000000000000000000000000000000000000000000000000000000000000004783 241.0
HKD2_k127_3207903_2 Aldehyde dehydrogenase - - - 0.0000000000000000000000000000000000000000000002561 188.0
HKD2_k127_3207903_3 protocatechuate 3,4-dioxygenase activity K03286,K03640,K07275 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.0000000000000000000000001004 119.0
HKD2_k127_3207903_4 - - - - 0.00000000001099 70.0
HKD2_k127_3278837_0 Belongs to the CarB family K01955 - 6.3.5.5 6.062e-263 823.0
HKD2_k127_3278837_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 623.0
HKD2_k127_3292848_1 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001098 252.0
HKD2_k127_3314317_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 542.0
HKD2_k127_3314317_1 4Fe-4S binding domain K08358 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006786 359.0
HKD2_k127_3314317_2 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K04013,K15876 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002119 321.0
HKD2_k127_3314317_3 Calcineurin-like phosphoesterase - - - 0.00000000000000000000001687 109.0
HKD2_k127_3314317_4 PFAM Polysulphide reductase, NrfD K00185 - - 0.000000000005566 67.0
HKD2_k127_3387111_0 TIGRFAM Glyceraldehyde-3-phosphate dehydrogenase, type I K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002059 484.0
HKD2_k127_3387111_1 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006464 486.0
HKD2_k127_3387111_2 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K00090 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 308.0
HKD2_k127_3387111_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007037 293.0
HKD2_k127_3387111_4 FAD dependent oxidoreductase K07137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005227 265.0
HKD2_k127_3387111_5 Cold shock protein K03704 - - 0.00000000000000000000000000001915 118.0
HKD2_k127_3387111_6 Preprotein translocase SecG subunit K03075 - - 0.000000000000000000000001077 107.0
HKD2_k127_3387111_7 Desiccation protectant protein Lea14 homolog - GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006952,GO:0008150,GO:0009314,GO:0009416,GO:0009605,GO:0009607,GO:0009611,GO:0009620,GO:0009628,GO:0009642,GO:0009644,GO:0016020,GO:0043207,GO:0044424,GO:0044444,GO:0044464,GO:0048046,GO:0050832,GO:0050896,GO:0051704,GO:0051707,GO:0071944,GO:0098542 - 0.0000005689 59.0
HKD2_k127_3387111_8 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.00006972 55.0
HKD2_k127_3433120_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001662 359.0
HKD2_k127_3433120_1 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000001475 242.0
HKD2_k127_3433120_2 Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose K00067 - 1.1.1.133 0.00000000000000000000000000000009678 130.0
HKD2_k127_3485117_0 Tetratricopeptide TPR_2 repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 338.0
HKD2_k127_3485117_1 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006419 333.0
HKD2_k127_3498676_0 MazG nucleotide pyrophosphohydrolase domain K02499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001386 270.0
HKD2_k127_3498676_1 PFAM PhoH family protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000001151 240.0
HKD2_k127_3498676_2 Domain of unknown function (DUF4388) - - - 0.0000000000000002219 93.0
HKD2_k127_3498676_3 Tetratricopeptide repeat - - - 0.00003677 57.0
HKD2_k127_3505966_0 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000000000000000000000000003353 222.0
HKD2_k127_3505966_1 Aminotransferase class-III K01845 - 5.4.3.8 0.0000000000000000000000003352 106.0
HKD2_k127_3505966_2 metal cluster binding K06940,K18475 - - 0.0000000000000000000000006718 109.0
HKD2_k127_3505966_3 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000000003915 93.0
HKD2_k127_3505966_4 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.0000000000008078 72.0
HKD2_k127_3514029_0 acyl-CoA transferases carnitine dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 363.0
HKD2_k127_3514029_1 Calcineurin-like phosphoesterase K03269 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 0.000000000000000000000000000000000000000004636 170.0
HKD2_k127_3552282_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 7.962e-212 681.0
HKD2_k127_3552282_1 DNA protecting protein DprA K04096 - - 0.000000000000000000000000000000000000000000000000000000002599 210.0
HKD2_k127_3585614_0 Beta-lactamase domain protein K06897 - 2.5.1.105 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000018 387.0
HKD2_k127_3585614_1 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 324.0
HKD2_k127_3585614_2 PFAM Branched-chain amino acid transport system permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004206 322.0
HKD2_k127_3585614_3 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004835 294.0
HKD2_k127_3585614_4 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005902 287.0
HKD2_k127_3585614_5 Amino acid amide ABC transporter ATP-binding protein 1, HAAT family K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003578 266.0
HKD2_k127_3585614_6 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001314 263.0
HKD2_k127_3585614_7 Histone deacetylase domain - - - 0.00000000000000000000000000000000000003779 147.0
HKD2_k127_3585614_8 Thiamine-binding protein - - - 0.000000000000000000000000000000000008379 141.0
HKD2_k127_3602853_0 Amino acid permease - - - 1.553e-206 662.0
HKD2_k127_3602853_1 Amino acid permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 420.0
HKD2_k127_3602853_2 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000002907 239.0
HKD2_k127_3602853_3 Universal stress protein family - - - 0.0000000000000000106 90.0
HKD2_k127_3602853_4 - - - - 0.0000000002743 66.0
HKD2_k127_360523_0 Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 396.0
HKD2_k127_360523_1 4Fe-4S dicluster domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003806 300.0
HKD2_k127_360523_2 PFAM glycine cleavage H-protein - - - 0.000000000000000000000000239 115.0
HKD2_k127_360523_3 Glycine cleavage H-protein - - - 0.0000000000000000000000006203 113.0
HKD2_k127_3620742_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002963 613.0
HKD2_k127_3620742_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 580.0
HKD2_k127_3620742_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000000000000000003011 208.0
HKD2_k127_3620742_3 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.00000000000000000000000000000000000000000000000000001554 197.0
HKD2_k127_3620742_4 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000001094 119.0
HKD2_k127_366295_0 LysM domain - - - 0.000000000246 73.0
HKD2_k127_377036_0 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001721 327.0
HKD2_k127_377036_1 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000004831 208.0
HKD2_k127_377036_2 histidine kinase HAMP region domain protein - - - 0.000000000000000000002913 103.0
HKD2_k127_3778149_0 cytochrome complex assembly - - - 0.00000000000000000000000001413 118.0
HKD2_k127_3778149_1 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.000000000000004581 81.0
HKD2_k127_3788927_0 Thiamine pyrophosphate enzyme, central domain K01608 - 4.1.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 612.0
HKD2_k127_3788927_1 hydroxyacid-oxoacid transhydrogenase activity K18120 - 1.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000224 513.0
HKD2_k127_3788927_2 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003852 367.0
HKD2_k127_3788927_3 2-dehydropantoate 2-reductase K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000003965 266.0
HKD2_k127_3834683_0 Bacterial regulatory protein, Fis family K10941 - - 0.000000000000000000000000000000000000000000000000000000000000004878 236.0
HKD2_k127_3834683_1 PFAM ATPase associated with various cellular activities - - - 0.0000000000287 70.0
HKD2_k127_3866820_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003304 602.0
HKD2_k127_3866820_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002692 332.0
HKD2_k127_3866820_2 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001468 287.0
HKD2_k127_3866820_3 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.0000000000000000000005354 104.0
HKD2_k127_3866820_5 Cell division protein ZapB - - - 0.0006697 45.0
HKD2_k127_3874135_0 Histidine kinase K10715,K20974 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005796 526.0
HKD2_k127_3874135_1 Enoyl-CoA hydratase/isomerase K13816 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001345 265.0
HKD2_k127_3878168_0 Domain of unknown function (DUF814) - - - 0.0000000000000000000000000000000000000002889 164.0
HKD2_k127_3878168_1 PFAM alpha beta hydrolase fold - - - 0.00000000000000000000000002258 110.0
HKD2_k127_3886973_0 PFAM peptidase S1 and S6, chymotrypsin Hap K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 347.0
HKD2_k127_3886973_1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.00000000000000000000000000000000005965 141.0
HKD2_k127_3912633_0 Phosphoadenosine phosphosulfate reductase family K21947 - 2.8.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 327.0
HKD2_k127_3912633_1 electron transfer flavoprotein, alpha subunit K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006572 318.0
HKD2_k127_3912633_2 Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005294 289.0
HKD2_k127_3912633_3 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006313 259.0
HKD2_k127_3912633_4 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA K07442 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016426,GO:0016429,GO:0016740,GO:0016741,GO:0030488,GO:0031515,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.219,2.1.1.220 0.000000000000000000000000000000000000000000000000000000000000000000007809 258.0
HKD2_k127_3912633_5 PFAM VanZ like - - - 0.0000000007142 65.0
HKD2_k127_3912633_6 thiamine diphosphate biosynthetic process K03154 - - 0.000000003532 65.0
HKD2_k127_3912633_7 Cytochrome c - - - 0.000131 49.0
HKD2_k127_3930171_0 acyl-CoA dehydrogenase activity K00252 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.3.8.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 511.0
HKD2_k127_3930171_1 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008371 493.0
HKD2_k127_3930171_2 IclR helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000133 174.0
HKD2_k127_3930171_3 Thioesterase-like superfamily K02614 - - 0.00000000000003623 80.0
HKD2_k127_3930171_4 Metallo-beta-lactamase superfamily - - - 0.0000003037 53.0
HKD2_k127_3930171_5 Domain of unknown function (DUF1858) - - - 0.00000294 52.0
HKD2_k127_3934531_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003267 494.0
HKD2_k127_3934531_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 343.0
HKD2_k127_3934531_2 Cytochrome C assembly protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 330.0
HKD2_k127_3934531_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000694 187.0
HKD2_k127_3934531_4 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.00000000000000006432 85.0
HKD2_k127_3938099_0 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008018 371.0
HKD2_k127_3938099_1 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000001327 182.0
HKD2_k127_3938099_2 KR domain K00059 - 1.1.1.100 0.00000000000000006805 97.0
HKD2_k127_3964410_0 Bacterial transcriptional activator domain - - - 2.144e-198 656.0
HKD2_k127_3964410_1 histidine kinase, HAMP K13598 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007223 488.0
HKD2_k127_3964410_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005267 441.0
HKD2_k127_3964410_3 Receptor K02014,K16087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007639 302.0
HKD2_k127_3964410_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000001075 140.0
HKD2_k127_3964410_5 Protein of unknown function (DUF2905) - - - 0.000000000000000143 91.0
HKD2_k127_3964410_6 Domain of unknown function (DUF4390) - - - 0.00000000002302 74.0
HKD2_k127_3964410_7 serine threonine protein kinase K12132 - 2.7.11.1 0.00001386 53.0
HKD2_k127_3969099_0 IMP dehydrogenase / GMP reductase domain K00088 - 1.1.1.205 1.049e-203 652.0
HKD2_k127_3969099_1 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 1.841e-202 642.0
HKD2_k127_3969099_2 DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 609.0
HKD2_k127_3969099_3 Ppx/GppA phosphatase family K01524 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0040007,GO:0044237,GO:0044464,GO:0071944 3.6.1.11,3.6.1.40 0.000000000000000000000000000000001074 139.0
HKD2_k127_3984775_0 Protein of unknown function (DUF3300) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 426.0
HKD2_k127_3984775_1 Protein of unknown function (DUF2950) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000466 397.0
HKD2_k127_3984775_3 overlaps another CDS with the same product name - - - 0.0000000000000000000000000777 112.0
HKD2_k127_3990291_0 COG4775 Outer membrane protein protective antigen OMA87 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 344.0
HKD2_k127_3990291_1 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002945 315.0
HKD2_k127_3990291_2 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000716 72.0
HKD2_k127_4004794_0 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002897 447.0
HKD2_k127_4004794_1 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 409.0
HKD2_k127_4037654_0 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 1.933e-198 634.0
HKD2_k127_4037654_1 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008098 445.0
HKD2_k127_4037654_2 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 439.0
HKD2_k127_4037654_3 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000001381 186.0
HKD2_k127_4037654_4 thioesterase K07107 - - 0.0000000000000000000000000003617 122.0
HKD2_k127_4037654_5 - - - - 0.00000000001113 70.0
HKD2_k127_4056080_0 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000939 430.0
HKD2_k127_4056080_1 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 321.0
HKD2_k127_4056080_2 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935 - 6.3.3.3 0.000000000000000000000000000000000000000005939 164.0
HKD2_k127_4058740_0 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005793 399.0
HKD2_k127_4058740_1 Dolichyl-phosphate-mannose-protein mannosyltransferase K19302 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005224 290.0
HKD2_k127_4061257_0 Dihydrolipoyl dehydrogenase K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 423.0
HKD2_k127_4061257_1 PFAM Aldehyde dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007668 409.0
HKD2_k127_4061257_2 2-oxoisovalerate dehydrogenase K00167,K21417 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 368.0
HKD2_k127_4061257_3 COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005438 325.0
HKD2_k127_4061257_4 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003006 298.0
HKD2_k127_4061257_5 e3 binding domain K00658 - 2.3.1.61 0.000000000000000000000000000000004367 139.0
HKD2_k127_4086978_0 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004936 303.0
HKD2_k127_4086978_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002641 262.0
HKD2_k127_4086978_2 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000005554 239.0
HKD2_k127_4127688_0 Glucodextranase, domain N K01178 - 3.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 587.0
HKD2_k127_4127688_1 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002008 287.0
HKD2_k127_4127688_2 Protein of unknown function (DUF1614) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000714 257.0
HKD2_k127_4127688_3 Predicted membrane protein (DUF2127) - - - 0.000000000000000000000000000000000000000000000002604 180.0
HKD2_k127_4127688_4 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.000000000000000000000000000000000000000003948 166.0
HKD2_k127_4127688_5 Doxx family K15977 - - 0.000001612 51.0
HKD2_k127_4145790_0 Glycosyl hydrolase family 57 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008933 490.0
HKD2_k127_4145790_1 DNA polymerase alpha chain like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000233 266.0
HKD2_k127_4145790_2 Protein conserved in bacteria - - - 0.000000000002387 76.0
HKD2_k127_4152754_0 PFAM binding-protein-dependent transport systems inner membrane component K02011 - - 6.225e-240 754.0
HKD2_k127_4152754_1 Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate K10206 GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769 2.6.1.83 4.327e-227 707.0
HKD2_k127_4152754_2 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006284 474.0
HKD2_k127_4152754_3 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000529 467.0
HKD2_k127_4152754_4 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K01838 - 5.4.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000615 243.0
HKD2_k127_4152754_5 - - - - 0.00000000000000000000000000000000000000002457 162.0
HKD2_k127_4152754_6 protein conserved in bacteria - - - 0.000000000000000000000000000000003996 132.0
HKD2_k127_4152754_7 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000955 96.0
HKD2_k127_4152754_8 NUDIX domain K01515 - 3.6.1.13 0.0000002439 53.0
HKD2_k127_4158851_0 Molybdopterin oxidoreductase Fe4S4 domain K08357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004811 458.0
HKD2_k127_4158851_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002471 289.0
HKD2_k127_4158851_2 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000003544 158.0
HKD2_k127_4198755_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003542 261.0
HKD2_k127_4198755_1 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis - - - 0.000000000000000000000000000000000004916 149.0
HKD2_k127_4198755_2 PFAM conserved K07027 - - 0.0000000000000000000000000001023 129.0
HKD2_k127_4198755_3 Dolichyl-phosphate-mannose-protein mannosyltransferase K19302 - 3.6.1.27 0.000000008114 61.0
HKD2_k127_4205_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 5.063e-287 911.0
HKD2_k127_4205_1 Translation-initiation factor 2 K02519 - - 4.579e-239 758.0
HKD2_k127_4205_10 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000002674 128.0
HKD2_k127_4205_11 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000008876 100.0
HKD2_k127_4205_12 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000186 99.0
HKD2_k127_4205_13 Protein of unknown function (DUF503) K09764 - - 0.000000000002821 73.0
HKD2_k127_4205_2 polyribonucleotide nucleotidyltransferase activity K00962 GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 2.108e-236 752.0
HKD2_k127_4205_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004763 570.0
HKD2_k127_4205_4 Belongs to the peptidase M16 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005698 349.0
HKD2_k127_4205_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000481 306.0
HKD2_k127_4205_6 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004587 289.0
HKD2_k127_4205_7 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000001234 196.0
HKD2_k127_4205_8 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.0000000000000000000000000000000000000000000000000001033 207.0
HKD2_k127_4205_9 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.000000000000000000000000000000000000000000000004636 179.0
HKD2_k127_4208506_0 Histidine kinase K02668,K07709 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000007025 269.0
HKD2_k127_4208506_1 PFAM type II secretion system K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000344 219.0
HKD2_k127_4208506_2 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.000000000000000000000000000000000006185 143.0
HKD2_k127_4210048_0 AAA domain (dynein-related subfamily) K03404,K03405 - 6.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008462 334.0
HKD2_k127_4210048_1 Magnesium chelatase, subunit ChlI K03404,K03405 - 6.6.1.1 0.00000000001699 72.0
HKD2_k127_4218159_0 TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family K03296,K18138 - - 0.0 1632.0
HKD2_k127_4218159_1 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0 1135.0
HKD2_k127_4218159_10 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 319.0
HKD2_k127_4218159_11 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003481 276.0
HKD2_k127_4218159_12 HlyD membrane-fusion protein of T1SS K03543 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002026 284.0
HKD2_k127_4218159_13 lysyl-tRNA synthetase K04568 - - 0.00000000000000000000000000000000000000000000000000000000000000000001824 247.0
HKD2_k127_4218159_14 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) - - - 0.00000000000000000000000000000000000000000000000000000000000001937 233.0
HKD2_k127_4218159_15 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.0000000000000000000000000000000000000000000003501 171.0
HKD2_k127_4218159_16 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000704 164.0
HKD2_k127_4218159_17 PFAM regulatory protein TetR - - - 0.000000000000000000001056 112.0
HKD2_k127_4218159_18 OsmC-like protein - - - 0.000000001394 62.0
HKD2_k127_4218159_19 Thioesterase superfamily K02614 - - 0.000000009926 67.0
HKD2_k127_4218159_2 Sugar (and other) transporter K03446 - - 6.888e-199 632.0
HKD2_k127_4218159_3 PFAM Outer membrane efflux protein K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002864 593.0
HKD2_k127_4218159_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007363 524.0
HKD2_k127_4218159_5 belongs to the aldehyde dehydrogenase family K00128,K00131,K00135,K00140 - 1.2.1.16,1.2.1.18,1.2.1.20,1.2.1.27,1.2.1.3,1.2.1.79,1.2.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 517.0
HKD2_k127_4218159_6 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 389.0
HKD2_k127_4218159_7 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 332.0
HKD2_k127_4218159_8 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006728 323.0
HKD2_k127_4218159_9 Major Facilitator Superfamily K08223 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009853 324.0
HKD2_k127_4228181_0 Participates in both transcription termination and antitermination K02600 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002058 426.0
HKD2_k127_4228181_1 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004761 362.0
HKD2_k127_4228181_2 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000000005823 122.0
HKD2_k127_4228181_3 Dihydroorotate dehydrogenase K02823 - - 0.00000000000000000000008478 102.0
HKD2_k127_4228181_4 Protein of unknown function (DUF448) K07742 - - 0.000000005748 63.0
HKD2_k127_4228181_5 Translation-initiation factor 2 K02519 - - 0.00000004816 58.0
HKD2_k127_423737_0 PFAM DAHP synthetase I KDSA K03856,K04516 - 2.5.1.54,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007814 445.0
HKD2_k127_423737_1 Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage K00772 - 2.4.2.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 331.0
HKD2_k127_423737_2 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008289,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031406,GO:0031975,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042277,GO:0042546,GO:0042597,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071723,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000006897 222.0
HKD2_k127_423737_3 - - - - 0.0000000003233 70.0
HKD2_k127_423737_4 Protein of unknown function (DUF507) - - - 0.00004517 49.0
HKD2_k127_4262538_0 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000003376 193.0
HKD2_k127_4262538_1 PFAM Type II secretion system protein E K02454,K02652 - - 0.0000000000000000000000000000000000000001046 173.0
HKD2_k127_4262538_2 AMP-dependent synthetase K01897 - 6.2.1.3 0.00000000000000000000000000000000000001294 152.0
HKD2_k127_4262538_3 Nitroreductase family - - - 0.00000000000000000000000000000001618 138.0
HKD2_k127_4338401_0 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001782 256.0
HKD2_k127_4338401_1 Cupin 2, conserved barrel - - - 0.000000000000000000000000000000000000000000000000001848 186.0
HKD2_k127_4338401_2 Haem-degrading - - - 0.00000000000000000000000000000000435 138.0
HKD2_k127_4338401_3 Uncharacterised protein family UPF0047 - - - 0.00000002483 66.0
HKD2_k127_4338401_4 - - - - 0.00002109 56.0
HKD2_k127_4363678_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004724 479.0
HKD2_k127_4363678_1 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 421.0
HKD2_k127_4363678_2 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 372.0
HKD2_k127_4363678_3 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007733 289.0
HKD2_k127_4363678_4 SMART Elongator protein 3 MiaB NifB K18707 - 2.8.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003153 293.0
HKD2_k127_4363678_5 Transcriptional regulator K13643 - - 0.000000000000000000000000002532 124.0
HKD2_k127_4363678_6 Competence protein ComEA helix-hairpin-helix repeat K02237 - - 0.00005266 52.0
HKD2_k127_4366298_0 Belongs to the glycosyl hydrolase 57 family K22451 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 463.0
HKD2_k127_4366298_1 PFAM phosphate transporter K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001813 381.0
HKD2_k127_4366298_2 PFAM membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000005054 251.0
HKD2_k127_4366298_3 lactoylglutathione lyase activity K01759,K01849,K05606 - 4.4.1.5,5.1.99.1,5.4.99.2 0.0000000000000000000000000000000000000000000001339 171.0
HKD2_k127_4366298_4 Glutaredoxin K03676 - - 0.00000004946 55.0
HKD2_k127_4366298_5 Rubrerythrin - - - 0.00001909 53.0
HKD2_k127_4411433_0 Forkhead associated domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006353 308.0
HKD2_k127_4411433_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000000000000000000000000000000000000000000000000000001753 225.0
HKD2_k127_4417069_0 AIR synthase related protein domain protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 396.0
HKD2_k127_4417069_1 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000076 224.0
HKD2_k127_4417069_2 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.00000000000000000000000000000000000003425 153.0
HKD2_k127_4477523_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002529 276.0
HKD2_k127_4477523_1 Class III cytochrome C family - - - 0.000000004104 62.0
HKD2_k127_4479165_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 427.0
HKD2_k127_4479165_1 ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 317.0
HKD2_k127_4479165_2 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.0000000000000000000000000005509 127.0
HKD2_k127_4479165_3 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.0000001632 53.0
HKD2_k127_4545514_0 aconitate hydratase activity K01681 - 4.2.1.3 7.526e-271 848.0
HKD2_k127_4545514_1 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 378.0
HKD2_k127_4545514_2 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007128 291.0
HKD2_k127_4545514_3 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000001912 215.0
HKD2_k127_4545514_4 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000008699 216.0
HKD2_k127_4545514_5 phosphinothricin N-acetyltransferase activity - - - 0.0000000000000000000000000000000000000002148 164.0
HKD2_k127_458292_0 - - - - 0.000000000317 64.0
HKD2_k127_4642627_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004535 349.0
HKD2_k127_4649774_0 Belongs to the class I fructose-bisphosphate aldolase family K01623 - 4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007637 435.0
HKD2_k127_4649774_1 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000004144 149.0
HKD2_k127_4649774_2 COG0023 Translation initiation factor 1 (eIF-1 SUI1) and related proteins K03113 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000005111 149.0
HKD2_k127_4649774_3 Domain of Unknown Function (DUF748) - - - 0.000000000000000008728 91.0
HKD2_k127_4682301_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 356.0
HKD2_k127_4682301_1 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000003379 244.0
HKD2_k127_4682301_2 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.0000000000000000000000000000000000000000000000000000001046 209.0
HKD2_k127_4682301_3 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000000000003007 169.0
HKD2_k127_4682301_4 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000843 152.0
HKD2_k127_4699445_0 PFAM Cytochrome b5 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006339 315.0
HKD2_k127_4699445_1 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000000000000000000000005039 213.0
HKD2_k127_4699445_2 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000001068 166.0
HKD2_k127_4699445_3 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.00000000001265 64.0
HKD2_k127_475222_0 PFAM type II secretion system protein E K02283,K03609 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 572.0
HKD2_k127_475222_1 AAA domain K02282 - - 0.000000000000000000000000000000000000000000000000001283 198.0
HKD2_k127_4760278_0 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 378.0
HKD2_k127_4760278_1 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000001316 106.0
HKD2_k127_4760278_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.00000000000000000006486 98.0
HKD2_k127_4760278_3 Histidine kinase - - - 0.0000002969 55.0
HKD2_k127_4780239_0 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00001,K14446 - 1.1.1.1,1.3.1.85 0.0000000000000000000000000000000000000006172 166.0
HKD2_k127_4780239_1 Cold shock protein K03704 - - 0.0000000000000000000000009379 105.0
HKD2_k127_4780239_2 Alanine dehydrogenase/PNT, N-terminal domain K00324 - 1.6.1.2 0.0000000000007309 70.0
HKD2_k127_478596_0 PFAM Type II secretion system protein E K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003311 433.0
HKD2_k127_478596_1 Pilus formation protein N terminal region K02280 - - 0.0000000000000000000000000000000000000000000001354 177.0
HKD2_k127_478596_2 Type II secretion system (T2SS), protein F - - - 0.000000004905 67.0
HKD2_k127_4814383_0 Radical SAM K01843 - 5.4.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 445.0
HKD2_k127_4814383_1 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 319.0
HKD2_k127_4814383_2 Belongs to the D-alanine--D-alanine ligase family K01921,K01955 - 6.3.2.4,6.3.5.5 0.00000000000000000000000000000000000000000000000000004068 211.0
HKD2_k127_4814383_3 acetyltransferase K18815 - 2.3.1.82 0.0000000000000000000000000000000000002029 148.0
HKD2_k127_4814383_4 Helix-turn-helix domain - - - 0.00000000000000000000000000000000002008 141.0
HKD2_k127_4824444_0 DMT(Drug metabolite transporter) superfamily permease - - - 0.0000000000000000000000000000000000000000000000000007949 193.0
HKD2_k127_4824444_1 - - - - 0.000000000000002225 84.0
HKD2_k127_4824444_2 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.000000000003024 66.0
HKD2_k127_4824444_3 - - - - 0.0000000008487 66.0
HKD2_k127_5000089_0 Calcineurin-like phosphoesterase K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 340.0
HKD2_k127_5000089_1 PFAM Aminotransferase class I and II - - - 0.00000000009863 74.0
HKD2_k127_5000089_2 Glutamine amidotransferases class-II K07008 - 3.5.1.118 0.0000000002022 72.0
HKD2_k127_5000089_3 Zinc ribbon domain - - - 0.000000000864 64.0
HKD2_k127_5031407_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 8.286e-221 693.0
HKD2_k127_5031407_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 307.0
HKD2_k127_5031407_2 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000000000000000000002673 113.0
HKD2_k127_5041883_0 Rad51 K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 474.0
HKD2_k127_5041883_1 PBS lyase HEAT-like repeat - - - 0.00000000000000000000000000000000000002057 165.0
HKD2_k127_5041883_2 Belongs to the CinA family K03743 - 3.5.1.42 0.000000000000000000000000000000007698 141.0
HKD2_k127_5041883_3 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.000000000000000000000000008931 123.0
HKD2_k127_5041883_4 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000008093 104.0
HKD2_k127_5041883_5 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.0000000000006657 78.0
HKD2_k127_5046514_0 Quinohemoprotein amine dehydrogenase, alpha subunit domain II K08685 - 1.4.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 322.0
HKD2_k127_5046514_1 4Fe-4S single cluster domain K06871 - - 0.000000000000000000000000000000000000000000000000000002775 203.0
HKD2_k127_5046514_2 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000000000000000003699 148.0
HKD2_k127_5054777_0 response regulator K10943 - - 0.00000000000000000000000000000000000000000000000000000000000000009336 229.0
HKD2_k127_5054777_1 signal transduction histidine kinase K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000009176 179.0
HKD2_k127_5054777_2 response regulator, receiver K13924 - 2.1.1.80,3.1.1.61 0.000007097 54.0
HKD2_k127_5089422_0 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000001303 225.0
HKD2_k127_5089422_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.00000000000000000000000000001502 127.0
HKD2_k127_513135_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1425.0
HKD2_k127_513135_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006371 340.0
HKD2_k127_513135_2 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000001206 210.0
HKD2_k127_513135_3 Thioesterase K18700 - 3.1.2.29 0.00000000000000000000000000000000000000000000000001184 183.0
HKD2_k127_5136836_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002204 265.0
HKD2_k127_5136836_1 response regulator - - - 0.000000000000000003099 89.0
HKD2_k127_5136836_2 A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics K18455 GO:0003674,GO:0005488,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009636,GO:0009987,GO:0010126,GO:0010127,GO:0016137,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050896,GO:0051186,GO:0071704,GO:0098754,GO:1901135,GO:1901657 3.5.1.115 0.0000000000000001558 85.0
HKD2_k127_5158335_0 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000918 203.0
HKD2_k127_5158335_1 lipid a biosynthesis K02517 - 2.3.1.241 0.00000000000000000000000001494 117.0
HKD2_k127_5178742_0 Quinohemoprotein amine dehydrogenase - - - 0.0000000000000000000000002646 118.0
HKD2_k127_5178742_1 Quinohemoprotein amine dehydrogenase, gamma subunit - - - 0.000000000000000000003761 99.0
HKD2_k127_5178742_2 Radical SAM superfamily K06871 - - 0.00000000000003423 73.0
HKD2_k127_5178950_0 TIGRFAM Ammonium transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 553.0
HKD2_k127_5178950_1 Belongs to the P(II) protein family K04751,K04752 - - 0.000000000000000000000000000000000000000000000001883 175.0
HKD2_k127_5178950_2 Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source K18928 - - 0.0003638 46.0
HKD2_k127_5211897_0 Pfam Anion-transporting ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003228 525.0
HKD2_k127_5211897_1 Sodium Bile acid symporter family K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 483.0
HKD2_k127_5211897_2 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006882 274.0
HKD2_k127_5211897_3 - - - - 0.000000000000000000001167 95.0
HKD2_k127_5211897_4 Arsenic resistance operon repressor - - - 0.000000000000000000002481 97.0
HKD2_k127_5211897_5 peroxiredoxin activity K01607 - 4.1.1.44 0.0000000000000000000176 93.0
HKD2_k127_5211897_6 Regulatory protein, FmdB family - - - 0.0000005097 53.0
HKD2_k127_5220580_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1272.0
HKD2_k127_5220580_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 1.152e-209 661.0
HKD2_k127_5220580_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000001106 220.0
HKD2_k127_5220580_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.0000000000000000000000000000000000000000000000000000000000008178 216.0
HKD2_k127_5233618_0 homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 1.957e-274 858.0
HKD2_k127_5233618_1 B12 binding domain K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 417.0
HKD2_k127_5233618_2 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000002586 130.0
HKD2_k127_5233618_3 PFAM Rubredoxin-type Fe(Cys)4 protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000002006 87.0
HKD2_k127_5279484_0 Belongs to the thiolase family K00626 - 2.3.1.9 2.996e-196 617.0
HKD2_k127_5279484_1 acyl-coa dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004427 443.0
HKD2_k127_5279484_2 Coenzyme A transferase K01039 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004295 402.0
HKD2_k127_5279484_3 TIGRFAM LAO AO transport system ATPase K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005679 352.0
HKD2_k127_5279484_4 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000000000000000000004254 238.0
HKD2_k127_5279484_5 Coenzyme A transferase K01040 - 2.8.3.12 0.00000000000003901 72.0
HKD2_k127_536553_0 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004998 543.0
HKD2_k127_536553_1 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009203 464.0
HKD2_k127_536553_2 ABC-type sugar transport system, permease component K02026 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 361.0
HKD2_k127_536553_3 Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 348.0
HKD2_k127_5417277_0 Domain of unknown function (DUF4921) K00965 - 2.7.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 286.0
HKD2_k127_5417277_1 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - 0.00000000000000000000000000000000000000000000000000000000000009815 229.0
HKD2_k127_5417277_2 TonB-dependent Receptor Plug Domain K16092 - - 0.0000000000000000000000000000000000000000000000000000000004807 225.0
HKD2_k127_5417277_3 Abc transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000132 220.0
HKD2_k127_5417277_4 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.000000000000000000000000000000000001285 143.0
HKD2_k127_5417277_5 Periplasmic binding protein K02016 - - 0.000000000000004719 79.0
HKD2_k127_5456629_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0 1151.0
HKD2_k127_5456629_1 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002598 276.0
HKD2_k127_5456629_2 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000006688 245.0
HKD2_k127_5456629_3 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000005437 226.0
HKD2_k127_5456629_4 Predicted membrane protein (DUF2318) - - - 0.0000000000000000000000000000002755 130.0
HKD2_k127_5476046_0 Peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 457.0
HKD2_k127_5476046_1 SNARE associated Golgi protein K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001232 304.0
HKD2_k127_5476046_2 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008469 320.0
HKD2_k127_550161_0 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000004606 267.0
HKD2_k127_550161_1 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000003782 173.0
HKD2_k127_550161_2 Polynucleotide kinase 3 phosphatase K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000004341 162.0
HKD2_k127_550161_3 tetraacyldisaccharide 4'-kinase activity K00912,K09791 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.7.1.130 0.0000000000000006159 78.0
HKD2_k127_550161_4 Protein of unknown function (DUF3108) - - - 0.00000000000009683 83.0
HKD2_k127_5523396_0 Biotin carboxylase K01961,K01965 - 6.3.4.14,6.4.1.2,6.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000185 592.0
HKD2_k127_5523396_1 Biotin-requiring enzyme - - - 0.0000000000000000000000000001059 134.0
HKD2_k127_5523396_2 Carboxyl transferase domain K01966,K17489 - 2.1.3.1,2.1.3.15,6.4.1.3 0.00000000000000000000000000305 111.0
HKD2_k127_5541798_0 FAD-dependent dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001874 615.0
HKD2_k127_5541798_1 GHMP kinases N terminal domain K07031 - 2.7.1.168 0.00000000000000000000000000000000000000000001878 175.0
HKD2_k127_5541798_2 Belongs to the RtcB family K14415 - 6.5.1.3 0.0000000000000000000000000006408 114.0
HKD2_k127_5541798_3 Belongs to the UPF0173 family - - - 0.0000000000000000008844 92.0
HKD2_k127_5550099_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 616.0
HKD2_k127_5550099_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001857 458.0
HKD2_k127_5550099_2 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004058 384.0
HKD2_k127_5550099_3 PFAM Radical SAM domain protein K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 361.0
HKD2_k127_5550099_4 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002032 254.0
HKD2_k127_5550099_5 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000000000000002303 96.0
HKD2_k127_5550099_6 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360 2.1.1.198 0.0000006437 54.0
HKD2_k127_5550099_7 PFAM Uncharacterised ACR, YagE family COG1723 - - - 0.0008731 44.0
HKD2_k127_5612036_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 4.72e-211 668.0
HKD2_k127_5612036_1 associated with various cellular activities K03695,K03696 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 520.0
HKD2_k127_5612036_10 Prokaryotic Cytochrome C oxidase subunit IV K02277 - 1.9.3.1 0.0000002853 55.0
HKD2_k127_5612036_2 exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 427.0
HKD2_k127_5612036_3 PFAM PfkB domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007349 370.0
HKD2_k127_5612036_4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001687 271.0
HKD2_k127_5612036_5 signal sequence binding K07152 - - 0.00000000000000000000000000000000000000000000000000002345 210.0
HKD2_k127_5612036_6 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000003714 196.0
HKD2_k127_5612036_7 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000001486 160.0
HKD2_k127_5612036_8 Histidine kinase K10715 - 2.7.13.3 0.00000000000000000000000000000006756 137.0
HKD2_k127_5612036_9 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.00000000000000000000000000006429 130.0
HKD2_k127_5617610_0 B12 binding domain K00548 - 2.1.1.13 2.368e-266 848.0
HKD2_k127_5617610_1 Belongs to the citrate synthase family K01647,K01659 - 2.3.3.1,2.3.3.5 4.902e-226 708.0
HKD2_k127_5617610_10 Belongs to the Fur family K03711,K09825 - - 0.00000000000000000000008042 102.0
HKD2_k127_5617610_11 TonB C terminal K03646 - - 0.00004051 55.0
HKD2_k127_5617610_2 SMART Nucleotide binding protein, PINc K07175 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005703 570.0
HKD2_k127_5617610_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 319.0
HKD2_k127_5617610_4 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.0000000000000000000000000000000000000000000000000000000000000000000003135 263.0
HKD2_k127_5617610_5 PFAM MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000000000000001925 200.0
HKD2_k127_5617610_6 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.000000000000000000000000000000000000000001012 172.0
HKD2_k127_5617610_7 Biopolymer transport protein ExbD/TolR K03560 - - 0.00000000000000000000000000000000000001344 152.0
HKD2_k127_5617610_8 PFAM OmpA MotB domain protein K03640 - - 0.0000000000000000000000000000000000006124 151.0
HKD2_k127_5617610_9 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000002414 139.0
HKD2_k127_563320_0 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003065 299.0
HKD2_k127_563320_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003271 278.0
HKD2_k127_563320_2 Belongs to the UPF0758 family K03630 - - 0.0000000000000000000000000000000000000000001873 165.0
HKD2_k127_563320_3 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000000001916 174.0
HKD2_k127_563320_4 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000000000000000000000000000000000008543 149.0
HKD2_k127_563320_5 Protein of unknown function DUF58 - - - 0.000000000000000000000000000001551 138.0
HKD2_k127_569522_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000001776 215.0
HKD2_k127_569522_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.000000000000000000000000000000000000000000001224 179.0
HKD2_k127_569522_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.000000000000000000000000000003628 121.0
HKD2_k127_569522_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000001083 101.0
HKD2_k127_5705687_0 Peptidase family U32 C-terminal domain K08303 - - 0.000000000000000000000005661 111.0
HKD2_k127_5705687_1 PFAM thioesterase superfamily K07107 - - 0.000000003988 61.0
HKD2_k127_5709463_0 Major Facilitator Superfamily K08224 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000513 422.0
HKD2_k127_5709463_1 - - - - 0.000000000000000000000000000000000000000001491 170.0
HKD2_k127_5709463_2 Dodecin K09165 - - 0.00000000000000000000000001165 110.0
HKD2_k127_5712267_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1097.0
HKD2_k127_5712267_1 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 414.0
HKD2_k127_5712267_2 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.00000000000000000000000000000000000000000000005185 172.0
HKD2_k127_5712267_3 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 0.0000000000000000000000000000000000000005017 154.0
HKD2_k127_5743356_0 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 327.0
HKD2_k127_5743356_1 DRTGG domain K13788 - 2.3.1.8 0.00000000000000000000000000000000000000000000001263 179.0
HKD2_k127_5758537_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 515.0
HKD2_k127_5758537_1 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000000001734 158.0
HKD2_k127_5758537_2 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000698 127.0
HKD2_k127_5758537_3 Tetratricopeptide TPR_2 repeat protein - - - 0.0000002367 62.0
HKD2_k127_5764115_0 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 457.0
HKD2_k127_5764115_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007215 404.0
HKD2_k127_5764115_2 Coenzyme A transferase K01039 - 2.8.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005521 401.0
HKD2_k127_5764115_3 Coenzyme A transferase K01040 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 355.0
HKD2_k127_5764115_4 TIGRFAM LAO AO transport system ATPase K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 345.0
HKD2_k127_5764115_5 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000000000000000000000000000002969 242.0
HKD2_k127_5764115_6 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000000000000000000000000000003418 228.0
HKD2_k127_5764115_7 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000000000000000000000000000004235 200.0
HKD2_k127_5764115_8 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000001235 167.0
HKD2_k127_5764115_9 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000006158 113.0
HKD2_k127_5879078_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 3.689e-287 905.0
HKD2_k127_5879078_1 COG2202 FOG PAS PAC domain - - - 0.00000000000000000000000004851 113.0
HKD2_k127_5879078_2 Glycosyl transferase, family 2 - - - 0.0000003193 53.0
HKD2_k127_5890942_0 methionine biosynthesis protein (MetW) - - - 0.000000000000000000000000000000000000000000000000000000000003542 223.0
HKD2_k127_5890942_1 Including oxidative damage repair enzymes - - - 0.000000000000000000000000000000000333 142.0
HKD2_k127_5890942_2 Conserved carboxylase domain K01958 - 6.4.1.1 0.000000000000000005249 85.0
HKD2_k127_5890942_3 - - - - 0.00002161 46.0
HKD2_k127_5930814_0 CBS domain containing protein K00974 - 2.7.7.72 1.374e-259 833.0
HKD2_k127_5930814_1 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 606.0
HKD2_k127_5930814_2 tRNA synthetases class I (W and Y) K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 412.0
HKD2_k127_5930814_3 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002468 285.0
HKD2_k127_5930814_4 Peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000001918 202.0
HKD2_k127_5930814_5 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.00000000000000000000000000000000000000000000000000004078 200.0
HKD2_k127_5930814_6 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000002039 173.0
HKD2_k127_5930814_7 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.0000000000000000000000000002739 122.0
HKD2_k127_5947565_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1347.0
HKD2_k127_5947565_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000152 203.0
HKD2_k127_5947565_2 - - - - 0.000000002486 64.0
HKD2_k127_6050321_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003668 416.0
HKD2_k127_6050321_1 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007193 297.0
HKD2_k127_6050321_2 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002891 271.0
HKD2_k127_6110390_0 PFAM aldo keto reductase K07079 - - 0.000000000000000000000000000000000000000000000000000000000000002896 232.0
HKD2_k127_6110390_1 Lipocalin-like domain K03098 - - 0.000000000000000000000000000000000000000000000000000002193 196.0
HKD2_k127_6110390_2 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000003479 189.0
HKD2_k127_6110390_3 Aldo/keto reductase family - - - 0.00000000000000000000000000002696 118.0
HKD2_k127_6110390_4 - - - - 0.0000003138 62.0
HKD2_k127_6204709_0 tail specific protease K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006967 456.0
HKD2_k127_6204709_1 Divergent polysaccharide deacetylase K09798 - - 0.00000000000000000000000000002214 134.0
HKD2_k127_6217469_0 bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 2.954e-195 623.0
HKD2_k127_6217469_1 Belongs to the GARS family K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008775 494.0
HKD2_k127_6217469_2 Protein of unknown function (DUF1015) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004194 357.0
HKD2_k127_6217469_3 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000001845 193.0
HKD2_k127_6217469_4 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000004372 165.0
HKD2_k127_6217469_5 PFAM methyltransferase K15460 - 2.1.1.223 0.000000000000000000000000000000000000002715 156.0
HKD2_k127_6217469_6 Belongs to the SUA5 family K07566 - 2.7.7.87 0.0000000000000000000000000000000002803 143.0
HKD2_k127_6252829_0 SMART helicase c2 K03722 - 3.6.4.12 0.000000000000000000000000000000001193 147.0
HKD2_k127_6252829_1 LppC putative lipoprotein K07121 - - 0.0000000000000000000000000003633 130.0
HKD2_k127_6327369_0 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007148 326.0
HKD2_k127_6327369_1 SMART helicase c2 K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000001246 229.0
HKD2_k127_6327369_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.000000000000000000001532 98.0
HKD2_k127_6327369_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000001748 73.0
HKD2_k127_6388955_0 2-hydroxyglutaryl-CoA dehydratase, D-component K04113 - 1.3.7.8 8.557e-247 777.0
HKD2_k127_6388955_1 Enoyl-CoA hydratase/isomerase K07539 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 1.265e-208 651.0
HKD2_k127_6388955_2 2-hydroxyglutaryl-CoA dehydratase, D-component K04112 - 1.3.7.8 5.262e-208 670.0
HKD2_k127_6388955_3 BadF/BadG/BcrA/BcrD ATPase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000175 283.0
HKD2_k127_6394109_0 COGs COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008398 278.0
HKD2_k127_6394109_1 Nucleotidyl transferase K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000001451 180.0
HKD2_k127_6394109_2 PFAM aminoglycoside phosphotransferase K07102 - 2.7.1.221 0.000004204 52.0
HKD2_k127_6431559_0 Seryl-tRNA synthetase N-terminal domain K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 533.0
HKD2_k127_6431559_1 Mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000002834 274.0
HKD2_k127_6431559_2 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000003432 153.0
HKD2_k127_6431559_3 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000002116 138.0
HKD2_k127_6431559_4 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.00000000000000000000003065 100.0
HKD2_k127_6431559_5 Rubrerythrin - - - 0.000000000000000116 87.0
HKD2_k127_6431559_6 Cytochrome b5-like Heme/Steroid binding domain - - - 0.0000000002297 66.0
HKD2_k127_6444336_0 Biotin and Thiamin Synthesis associated domain K01012,K16180 - 2.8.1.6,5.4.99.58 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 323.0
HKD2_k127_6444336_1 PFAM Haloacid dehalogenase domain protein hydrolase K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000001762 189.0
HKD2_k127_6444336_2 CAAX protease self-immunity K07052 - - 0.000000000008705 73.0
HKD2_k127_6469421_0 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006596 470.0
HKD2_k127_6469421_1 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 315.0
HKD2_k127_6469421_2 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001155 285.0
HKD2_k127_6469421_3 PFAM VacJ family lipoprotein K04754 - - 0.00000000000000000000000000000000000000000000000000000000000000002343 237.0
HKD2_k127_6469421_4 HAD-superfamily hydrolase, subfamily IA, variant 3 K07025 - - 0.00000000000000000000000000000000000000000000000001209 187.0
HKD2_k127_6469421_5 PFAM Mammalian cell entry related domain protein K02067 - - 0.0000000000000000000000000000000009118 132.0
HKD2_k127_6484642_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 522.0
HKD2_k127_6484642_1 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.00000000004635 69.0
HKD2_k127_6486860_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 374.0
HKD2_k127_6486860_1 Dimerisation domain - - - 0.0001492 49.0
HKD2_k127_6532863_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000371 309.0
HKD2_k127_6532863_1 PFAM Peptidase M23 - - - 0.00000000000000000000000000000000000000000000004521 182.0
HKD2_k127_6532863_2 protein conserved in bacteria K09798 - - 0.000000000000000000000000000000000000003163 157.0
HKD2_k127_6532863_3 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000517 64.0
HKD2_k127_6545449_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001379 263.0
HKD2_k127_6545449_1 - - - - 0.00000000000000000000002791 107.0
HKD2_k127_6551324_0 PFAM sigma-54 factor interaction domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 385.0
HKD2_k127_6551324_1 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000007622 256.0
HKD2_k127_6551324_2 Chalcone isomerase-like - - - 0.00000000000000000000000000000000000000000000000001205 186.0
HKD2_k127_6551324_3 MerR, DNA binding - - - 0.0000000000000000000000000000000000000001382 153.0
HKD2_k127_6551324_4 Sulfurtransferase - - - 0.000000000000000001378 89.0
HKD2_k127_6570921_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 4.78e-209 657.0
HKD2_k127_6570921_1 Anthranilate synthase component I, N terminal region K01657,K13503 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006523 503.0
HKD2_k127_6570921_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004139 458.0
HKD2_k127_6570921_3 Belongs to the TrpC family K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.000000000000000000000000000000000000000000000000000004136 204.0
HKD2_k127_6570921_4 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000006294 94.0
HKD2_k127_6570921_5 COG3087 Cell division protein K03591 - - 0.00001136 56.0
HKD2_k127_6570921_6 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.0006291 42.0
HKD2_k127_6585463_0 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 479.0
HKD2_k127_6585463_1 4Fe-4S dicluster domain K11473 - - 0.00000000000000000000000000000000000000000000000000000004687 222.0
HKD2_k127_6585463_2 Alpha beta hydrolase - - - 0.00000000000000000000000000001461 122.0
HKD2_k127_6609656_0 Belongs to the PEP-utilizing enzyme family K01006,K22424 - 2.7.3.13,2.7.9.1 0.0 1103.0
HKD2_k127_6609656_1 glycyl-tRNA aminoacylation K01879 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 606.0
HKD2_k127_6609656_2 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009851 518.0
HKD2_k127_6609656_3 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 420.0
HKD2_k127_6609656_4 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003903 354.0
HKD2_k127_6609656_5 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005478 349.0
HKD2_k127_6609656_6 Isocitrate dehydrogenase K00031 - 1.1.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 317.0
HKD2_k127_6609656_7 Tetratricopeptide repeat - - - 0.0000000000000000000000001226 123.0
HKD2_k127_6609656_8 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000002802 112.0
HKD2_k127_6609656_9 Domain of unknown function (DUF4115) K15539 - - 0.000000000000001401 90.0
HKD2_k127_6626649_0 Uncharacterised ArCR, COG2043 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 319.0
HKD2_k127_6626649_1 Thiopurine S-methyltransferase (TPMT) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001062 239.0
HKD2_k127_6626649_2 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000000000001746 206.0
HKD2_k127_6626649_3 phenylacetate-CoA ligase activity K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000002023 188.0
HKD2_k127_6626649_4 amino acid K03294 - - 0.000000000000000000000000009627 112.0
HKD2_k127_6626649_5 PFAM Cyclic nucleotide-binding K10914,K21563 - - 0.0000000000000000000001225 106.0
HKD2_k127_6690336_0 PFAM Aldehyde dehydrogenase - - - 7.479e-228 713.0
HKD2_k127_6690336_1 PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal K14534 - 4.2.1.120,5.3.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 537.0
HKD2_k127_6690336_2 PFAM AMP-dependent synthetase and ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 356.0
HKD2_k127_6690336_3 Enoyl-(Acyl carrier protein) reductase K00065 - 1.1.1.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 334.0
HKD2_k127_6690336_4 Amino acid amide ABC transporter ATP-binding protein 2, HAAT family K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 312.0
HKD2_k127_6690336_5 amino acid K01995 - - 0.0000000000000000000000000000000000008465 140.0
HKD2_k127_6690336_6 e3 binding domain K00627 - 2.3.1.12 0.000000000000000000001352 98.0
HKD2_k127_6692310_0 CHASE2 K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001032 356.0
HKD2_k127_6692310_1 FecR protein - - - 0.0000000000000000000000000000006303 128.0
HKD2_k127_6736380_0 Belongs to the peptidase M16 family K07263 - - 0.0 1071.0
HKD2_k127_6736380_1 6-phosphogluconate dehydrogenase (decarboxylating) K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009335 515.0
HKD2_k127_6736380_10 ABC transporter - - - 0.000000000000000000000000000000000000002574 149.0
HKD2_k127_6736380_11 Cytochrome C oxidase, cbb3-type, subunit III K08906 - - 0.000000000000000000000000000202 118.0
HKD2_k127_6736380_13 P pilus assembly Cpx signaling pathway, periplasmic inhibitor zinc-resistance associated protein K06006 - - 0.000000000000001962 83.0
HKD2_k127_6736380_14 RNA polymerase sigma factor K03088 - - 0.00001661 47.0
HKD2_k127_6736380_2 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) K03455 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006591 465.0
HKD2_k127_6736380_3 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 420.0
HKD2_k127_6736380_4 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004152 360.0
HKD2_k127_6736380_5 NAD+ diphosphatase activity K03426,K20449 - 1.3.7.1,3.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001924 303.0
HKD2_k127_6736380_6 PFAM Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001125 278.0
HKD2_k127_6736380_7 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000003298 184.0
HKD2_k127_6736380_8 Universal stress protein family - - - 0.000000000000000000000000000000000000000000007607 167.0
HKD2_k127_6736380_9 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000001462 173.0
HKD2_k127_6791159_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000227 275.0
HKD2_k127_6791159_1 Universal stress protein - - - 0.0000000000000000000000000000000000000000000000000000000000003496 225.0
HKD2_k127_6791159_2 Sodium Bile acid symporter family K03325 - - 0.0000000000000000000000000000000000000000000000000000007215 193.0
HKD2_k127_6826557_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003597 257.0
HKD2_k127_6826557_1 Amp-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000009775 230.0
HKD2_k127_6826557_2 LysM domain - - - 0.00000000001765 76.0
HKD2_k127_6840908_0 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 3.408e-239 745.0
HKD2_k127_6840908_1 CoA binding domain K09181 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005651 283.0
HKD2_k127_6840908_2 BadF/BadG/BcrA/BcrD ATPase family - - - 0.000000000000000000000000000000000000000000000001001 176.0
HKD2_k127_6889139_0 PFAM magnesium chelatase K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004345 422.0
HKD2_k127_6889139_1 PFAM Transglutaminase-like K22452 - 2.3.2.13 0.0002794 47.0
HKD2_k127_6896863_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 1.325e-228 724.0
HKD2_k127_6896863_1 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.0000000000000000000000000000000000006199 159.0
HKD2_k127_6896863_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.000000005706 59.0
HKD2_k127_6919241_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695,K03696 - - 0.0 1038.0
HKD2_k127_6919241_1 Heat shock 70 kDa protein K04043 - - 7.069e-281 876.0
HKD2_k127_6919241_10 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000001454 248.0
HKD2_k127_6919241_11 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000002728 219.0
HKD2_k127_6919241_12 His Kinase A (phosphoacceptor) domain K02668,K07708,K07709 - 2.7.13.3 0.000000000000000000000000000000000000000000000000004434 203.0
HKD2_k127_6919241_13 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000000000000000000000006133 188.0
HKD2_k127_6919241_14 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000001029 167.0
HKD2_k127_6919241_15 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 0.00000000000000000000000000000000000000000002299 170.0
HKD2_k127_6919241_16 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000009675 149.0
HKD2_k127_6919241_17 Single-strand binding protein family K03111 - - 0.0000000000000000000000000000000002555 141.0
HKD2_k127_6919241_18 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000004811 141.0
HKD2_k127_6919241_19 COG0351 Hydroxymethylpyrimidine phosphomethylpyrimidine kinase K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000334 141.0
HKD2_k127_6919241_2 Belongs to the ClpA ClpB family K03696 GO:0006950,GO:0008150,GO:0010035,GO:0010038,GO:0042221,GO:0046686,GO:0046688,GO:0050896,GO:0097501,GO:1990169,GO:1990170 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 492.0
HKD2_k127_6919241_20 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000004003 135.0
HKD2_k127_6919241_21 SpoVG K06412 - - 0.00000000000000000000000000002153 119.0
HKD2_k127_6919241_22 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000219 102.0
HKD2_k127_6919241_23 Binds together with S18 to 16S ribosomal RNA K02990 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000001246 89.0
HKD2_k127_6919241_25 Domain of unknown function (DUF1844) - - - 0.0000000001496 73.0
HKD2_k127_6919241_3 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 470.0
HKD2_k127_6919241_4 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 460.0
HKD2_k127_6919241_5 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 414.0
HKD2_k127_6919241_6 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 415.0
HKD2_k127_6919241_7 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 384.0
HKD2_k127_6919241_8 Bacterial regulatory protein, Fis family K07712 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007845 347.0
HKD2_k127_6919241_9 Phospholipase, patatin family K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004135 274.0
HKD2_k127_6928226_0 Domain of unknown function (DUF3390) K18929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001967 448.0
HKD2_k127_6928226_1 PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002053 383.0
HKD2_k127_6928226_2 Cysteine-rich domain K18928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002065 280.0
HKD2_k127_6928226_3 glutamate synthase (NADPH) K00266 - 1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000007144 161.0
HKD2_k127_6928226_4 Protein of unknown function (DUF3494) - - - 0.00000000000000000000002722 108.0
HKD2_k127_6928226_5 - - - - 0.00000000000000007276 89.0
HKD2_k127_6928226_6 LUD domain K00782 - - 0.0000000000006291 82.0
HKD2_k127_693786_0 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.0 1080.0
HKD2_k127_693786_1 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005601 300.0
HKD2_k127_693786_10 Thioesterase superfamily - - - 0.000000000000000000000000000001347 126.0
HKD2_k127_693786_11 PFAM Methyltransferase type 11 - - - 0.0000000000000000000000000002399 126.0
HKD2_k127_693786_12 Thioesterase K01075 - 3.1.2.23 0.000000000000000000000159 109.0
HKD2_k127_693786_13 transcriptional regulator - - - 0.000000000000000000001048 100.0
HKD2_k127_693786_14 YtxH-like protein - - - 0.000000000005742 75.0
HKD2_k127_693786_2 penicillin-binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009521 294.0
HKD2_k127_693786_3 Ferritin-like domain - GO:0003674,GO:0005488,GO:0005506,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050896 - 0.000000000000000000000000000000000000000000000000000000000000000000001169 241.0
HKD2_k127_693786_4 AAA domain, putative AbiEii toxin, Type IV TA system K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000001903 237.0
HKD2_k127_693786_5 Zinc-uptake complex component A periplasmic K09815 - - 0.0000000000000000000000000000000000000000000000000000000269 208.0
HKD2_k127_693786_6 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000000000008592 214.0
HKD2_k127_693786_7 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000003472 183.0
HKD2_k127_693786_8 ECF sigma factor K03088 - - 0.000000000000000000000000000000000000001826 154.0
HKD2_k127_693786_9 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000009822 154.0
HKD2_k127_6954321_0 SMART Elongator protein 3 MiaB NifB - - - 3.742e-206 669.0
HKD2_k127_6954321_1 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004294 577.0
HKD2_k127_6954321_2 sigma factor antagonist activity K04757 - 2.7.11.1 0.00000000000002588 87.0
HKD2_k127_6954321_3 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000001665 58.0
HKD2_k127_6968174_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00334,K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003956 535.0
HKD2_k127_6968174_1 NAD binding K00333,K13378 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 492.0
HKD2_k127_6968174_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000001164 222.0
HKD2_k127_6968174_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000646 185.0
HKD2_k127_6968174_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000001186 184.0
HKD2_k127_6968174_5 NADH-quinone oxidoreductase K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000008764 194.0
HKD2_k127_6968174_6 COG1034 NADH dehydrogenase NADH ubiquinone oxidoreductase 75 kD subunit (chain G) K00336 - 1.6.5.3 0.0000000000000000000000000000000000001353 145.0
HKD2_k127_6968174_7 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 - 1.6.5.3 0.0000000000000000000000000000000000001437 145.0
HKD2_k127_7039807_0 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002822 282.0
HKD2_k127_7039807_1 PFAM Methyladenine glycosylase K01246 - 3.2.2.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001559 271.0
HKD2_k127_7039807_2 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000241 173.0
HKD2_k127_7039807_3 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000002922 154.0
HKD2_k127_7039807_4 PFAM MaoC domain protein dehydratase - - - 0.0000000000000000000000000000000000003799 144.0
HKD2_k127_7052810_0 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000599 561.0
HKD2_k127_7052810_1 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 547.0
HKD2_k127_7052810_2 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 542.0
HKD2_k127_7052810_4 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.000003532 55.0
HKD2_k127_7114357_0 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000002522 155.0
HKD2_k127_7114357_1 Type II secretion system (T2SS), protein F - - - 0.00000000000000001279 87.0
HKD2_k127_7124629_0 Belongs to the NadC ModD family K00767 GO:0003674,GO:0003824,GO:0004514,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016054,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034213,GO:0034641,GO:0034654,GO:0042737,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0072526,GO:0090407,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000968 238.0
HKD2_k127_7124629_1 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 0.000000000000000000000000553 110.0
HKD2_k127_7310961_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0 1235.0
HKD2_k127_7310961_1 PFAM Cobalt uptake substrate-specific transmembrane region K02007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007558 387.0
HKD2_k127_7310961_2 PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 316.0
HKD2_k127_7328429_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 4.339e-216 699.0
HKD2_k127_7328429_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003572 572.0
HKD2_k127_7328429_2 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001864 292.0
HKD2_k127_7328429_3 Peptidase family S49 K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002756 280.0
HKD2_k127_7328429_4 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000004299 214.0
HKD2_k127_7328429_5 Bis-adenosyl-polyphosphate hydrolase, FHIT domain-containing K19710 - 2.7.7.53 0.000000000000000000000000000000000000000000006442 171.0
HKD2_k127_7328429_6 PFAM cell wall hydrolase autolysin K01448 - 3.5.1.28 0.00000000000000000000000000000000001041 148.0
HKD2_k127_7328429_7 bacterial (prokaryotic) histone like domain K05788 - - 0.000000000000000000000000000004592 121.0
HKD2_k127_7328429_8 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.0000000007993 60.0
HKD2_k127_7342439_0 KR domain K00023,K00059 - 1.1.1.100,1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000939 365.0
HKD2_k127_7342439_1 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 367.0
HKD2_k127_7342439_2 Amidohydrolase K07045 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003558 313.0
HKD2_k127_7342439_3 Enoyl-CoA hydratase/isomerase K07539 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016787,GO:0016822,GO:0016823,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035383,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901787,GO:1901788 3.7.1.21 0.0000000000000003292 78.0
HKD2_k127_7376446_0 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000108 349.0
HKD2_k127_7376446_1 AMMECR1 K09141 - - 0.000000000000000000000000000000000000000000000003333 179.0
HKD2_k127_7376446_2 metal-dependent phosphohydrolase HD region - - - 0.0000000000000000000000000000000000000000000000921 173.0
HKD2_k127_7377752_0 twitching motility protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000041 351.0
HKD2_k127_7377752_1 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K11645 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 335.0
HKD2_k127_7377752_2 ATP phosphoribosyltransferase K00765 GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 314.0
HKD2_k127_7377752_3 Protein of unknown function (DUF2400) - - - 0.0000000000000000000000000000000000000000000000000000361 199.0
HKD2_k127_7378495_0 UvrD/REP helicase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000003111 226.0
HKD2_k127_7479212_0 AIR synthase related protein, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 493.0
HKD2_k127_7479212_1 UDP-3-O-acyl N-acetylglycosamine deacetylase K02535,K13599 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 343.0
HKD2_k127_7479212_2 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000007215 239.0
HKD2_k127_7500805_0 Enoyl-(Acyl carrier protein) reductase K13775 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009043 407.0
HKD2_k127_7500805_1 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.000000000000000000000000000000000000000000000000000000000000000000003927 245.0
HKD2_k127_7529108_0 Protein of unknown function (DUF815) K06923 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 458.0
HKD2_k127_7529108_1 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009573 342.0
HKD2_k127_7529108_2 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) K05951 - 2.4.2.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 299.0
HKD2_k127_7529108_3 Belongs to the RtcB family K14415 - 6.5.1.3 0.000000000000000000000000002041 113.0
HKD2_k127_7529108_4 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000006338 65.0
HKD2_k127_7570364_0 HAMP domain K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 401.0
HKD2_k127_7570364_1 cyclic diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000005186 176.0
HKD2_k127_7570364_2 Peptidase family M54 K06974 - - 0.000307 45.0
HKD2_k127_7621845_0 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004881 355.0
HKD2_k127_7621845_1 intermembrane phospholipid transfer K07323 - - 0.000000000000000000000000000000000000000000000001107 181.0
HKD2_k127_7621845_2 PFAM Mammalian cell entry related domain protein K02067 - - 0.00000000000000000000000000000000000000000000001404 174.0
HKD2_k127_7621845_3 ABC transporter K02065 - - 0.000000000008185 66.0
HKD2_k127_7643705_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 295.0
HKD2_k127_7643705_1 radical SAM K06871 - - 0.0000000000000000000000000000000000000002408 160.0
HKD2_k127_7643705_2 Transcriptional - - - 0.000000000000000000000000000000000119 135.0
HKD2_k127_7647369_0 LD-carboxypeptidase K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000000379 204.0
HKD2_k127_7647369_1 cytochrome complex assembly - - - 0.000000000000000000000000000000000002154 148.0
HKD2_k127_7647369_2 ResB-like family - - - 0.00000000000000000000005558 111.0
HKD2_k127_7647369_3 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.0000000000001582 78.0
HKD2_k127_7652979_0 UPF0126 domain - - - 0.0000000000000000000000000000000000000000000000000000001004 207.0
HKD2_k127_7662092_0 Creatinase/Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006145 296.0
HKD2_k127_7662092_1 IMP dehydrogenase activity K00088 GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000001035 253.0
HKD2_k127_7662092_2 Glycosyltransferase Family 4 - - - 0.000000000000000000363 90.0
HKD2_k127_7701698_0 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000483 480.0
HKD2_k127_7701698_1 Ribosomal protein S1-like RNA-binding domain K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009295 415.0
HKD2_k127_7701698_2 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000384 374.0
HKD2_k127_7701698_3 esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 340.0
HKD2_k127_7701698_4 PFAM NUDIX hydrolase K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000286 263.0
HKD2_k127_7701698_5 YtxH-like protein - - - 0.0000000000000000000001418 102.0
HKD2_k127_774254_0 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000002457 237.0
HKD2_k127_774254_1 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000000000000000000145 231.0
HKD2_k127_774254_2 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000001948 118.0
HKD2_k127_774254_3 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.00000006605 54.0
HKD2_k127_7754588_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004541 399.0
HKD2_k127_7754588_1 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000006077 248.0
HKD2_k127_7754588_2 iron ion homeostasis - - - 0.000000000000000000000000000000000008634 158.0
HKD2_k127_7766033_0 PFAM ferredoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 316.0
HKD2_k127_7766033_1 CO dehydrogenase acetyl-CoA synthase delta subunit K00197 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000001836 226.0
HKD2_k127_7770288_0 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002842 441.0
HKD2_k127_7770288_1 Cytidylate kinase-like family - - - 0.000000000000000000000000000000000000000003035 166.0
HKD2_k127_7770288_2 PFAM YbaK prolyl-tRNA synthetase associated region - - - 0.0000000000000000000000002 120.0
HKD2_k127_7770288_3 - - - - 0.00000000002037 66.0
HKD2_k127_7771790_0 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K01706 - 4.2.1.40 1.666e-249 775.0
HKD2_k127_7771790_1 PFAM D-galactarate dehydratase Altronate hydrolase domain protein K01685,K01708,K16846 - 4.2.1.42,4.2.1.7,4.4.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 475.0
HKD2_k127_7771790_2 Dihydrodipicolinate synthetase family K01714,K22397 - 4.1.2.28,4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 420.0
HKD2_k127_7771790_3 helix_turn _helix lactose operon repressor K06145 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 366.0
HKD2_k127_7784384_0 PFAM Aminotransferase, class I K14261 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009968 573.0
HKD2_k127_7784384_1 Threonine synthase K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008889 501.0
HKD2_k127_7784384_2 PFAM aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 469.0
HKD2_k127_7784384_3 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 462.0
HKD2_k127_7784384_4 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000002139 87.0
HKD2_k127_7787272_0 diguanylate cyclase activity K02000,K04767,K05847,K07168,K09137 - 3.6.3.32 0.0000000000000000000000000000000000000000000002787 175.0
HKD2_k127_7787272_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.00000000000000000000000000000002401 130.0
HKD2_k127_7787272_2 PFAM nitrogen-fixing NifU domain protein - - - 0.000000000000000000000004499 104.0
HKD2_k127_7787272_3 Ferredoxin - GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114 - 0.00000000000000003835 82.0
HKD2_k127_7787493_0 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.144e-226 723.0
HKD2_k127_7787493_1 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000000001018 241.0
HKD2_k127_7787493_2 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000001605 76.0
HKD2_k127_7787493_3 N-terminal domain of unknown function (DUF4140) - - - 0.00004603 54.0
HKD2_k127_77880_0 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 320.0
HKD2_k127_77880_1 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.0000000000000000000000000000000000000000000000000000000000001355 222.0
HKD2_k127_77880_2 - - - - 0.000000000000000000000000000000000000000000000000000000001314 208.0
HKD2_k127_77880_3 TIGRFAM Molybdopterin-guanine dinucleotide biosynthesis protein B K03753,K13818 - 2.7.7.77 0.00000000000000000000000000000005439 129.0
HKD2_k127_77880_4 - - - - 0.00000000000000006245 88.0
HKD2_k127_7816674_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 447.0
HKD2_k127_7816674_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 442.0
HKD2_k127_7816674_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000001267 273.0
HKD2_k127_7816674_3 Dimerisation domain of Zinc Transporter K13283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001346 265.0
HKD2_k127_7816674_4 4Fe-4S single cluster domain K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000004272 228.0
HKD2_k127_7816674_5 FES K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000001492 177.0
HKD2_k127_7816674_6 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000003961 156.0
HKD2_k127_7816674_7 COG0477 Permeases of the major facilitator superfamily - - - 0.000000000000000000000005405 119.0
HKD2_k127_7816674_8 Pfam:DUF1049 - - - 0.00002731 51.0
HKD2_k127_7818293_0 General secretory system II, protein E domain protein K02652 - - 1.002e-227 718.0
HKD2_k127_7818293_1 twitching motility protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 562.0
HKD2_k127_7818293_2 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576 2.9.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006838 411.0
HKD2_k127_7818293_3 Type II secretion system K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 365.0
HKD2_k127_7818293_4 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007181 268.0
HKD2_k127_7818293_5 regulatory protein GntR HTH - - - 0.000000000000000000000000000000000000000000000000000000000000000000000102 248.0
HKD2_k127_7818293_6 Xylose isomerase-like TIM barrel - - - 0.000000000000000000000000000000000000000000003828 173.0
HKD2_k127_7818293_7 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000005857 178.0
HKD2_k127_7834090_0 PFAM Glu Leu Phe Val dehydrogenase K15371 - 1.4.1.2 0.0 1228.0
HKD2_k127_7834090_1 fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1184.0
HKD2_k127_7834090_2 Fumarate reductase, iron-sulfur protein K00240,K00245 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 452.0
HKD2_k127_7834090_3 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001667 449.0
HKD2_k127_7834090_4 fumarate reductase) cytochrome b subunit K00241 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005231 258.0
HKD2_k127_7834090_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.0000000000000000000000000000002253 135.0
HKD2_k127_7849909_0 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 1.231e-207 651.0
HKD2_k127_7849909_1 malic protein domain protein K00027,K00029 - 1.1.1.38,1.1.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 552.0
HKD2_k127_7849909_2 inositol-3-phosphate synthase activity K01858 GO:0003674,GO:0003824,GO:0004512,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009405,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016853,GO:0016872,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044272,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051704,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 383.0
HKD2_k127_7849909_3 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000000000000000003242 192.0
HKD2_k127_7849909_4 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000000000000000106 175.0
HKD2_k127_7849909_5 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.000000000000003397 75.0
HKD2_k127_7917167_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000454 532.0
HKD2_k127_7917167_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000001238 245.0
HKD2_k127_7917167_2 Histidine kinase K07709 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000002873 215.0
HKD2_k127_7927399_0 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003781 303.0
HKD2_k127_7927399_1 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000007722 200.0
HKD2_k127_7927399_2 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.0000000000000000000000000000000000000000000001996 173.0
HKD2_k127_7927399_3 Outer membrane protein (OmpH-like) K06142 - - 0.000005798 51.0
HKD2_k127_7935933_0 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 461.0
HKD2_k127_7935933_1 Histidine kinase - - - 0.0000000000000000000000000000004257 127.0
HKD2_k127_7937109_0 Mycolic acid cyclopropane synthetase K00574,K20238 - 2.1.1.317,2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 529.0
HKD2_k127_7937109_1 Domain of unknown function(DUF2779) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 530.0
HKD2_k127_7937109_2 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006172 259.0
HKD2_k127_7937109_3 - - - - 0.0000000000000000000000000000000000002571 147.0
HKD2_k127_7963663_0 metallopeptidase activity K01218,K13276 - 3.2.1.78 3.75e-287 919.0
HKD2_k127_7963663_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 539.0
HKD2_k127_7963663_2 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.00000000000000000000000000000000000000000003295 179.0
HKD2_k127_7963663_3 Cache_2 - - - 0.00000000000000000000000008166 123.0
HKD2_k127_7963663_4 Outer membrane protein beta-barrel domain - - - 0.0000000000000000000007917 105.0
HKD2_k127_7963663_5 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000003521 77.0
HKD2_k127_7963663_6 Domain of unknown function (DUF386) - - - 0.000000003721 57.0
HKD2_k127_7963663_7 - - - - 0.000000114 60.0
HKD2_k127_7963663_8 PFAM Polysulphide reductase, NrfD - - - 0.0000005215 51.0
HKD2_k127_8008479_0 Pyridine nucleotide-disulphide oxidoreductase K07137 - - 0.00000000000000000000000000000000000000000000000002112 187.0
HKD2_k127_8008479_1 Nucleic acid binding K03698 - - 0.00000000000000000000000000000000000000003203 158.0
HKD2_k127_8055973_0 PFAM Polysulphide reductase, NrfD K00185 - - 7.651e-206 647.0
HKD2_k127_8055973_1 PFAM 4Fe-4S K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 497.0
HKD2_k127_8055973_2 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002102 248.0
HKD2_k127_8061113_0 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004321 557.0
HKD2_k127_8061113_1 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 351.0
HKD2_k127_8061113_2 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004268 260.0
HKD2_k127_8061113_3 peroxiredoxin activity - - - 0.0000000000000000000000000000000001506 140.0
HKD2_k127_8061113_4 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000009289 137.0
HKD2_k127_8061113_5 4Fe-4S binding domain - - - 0.00000000006204 63.0
HKD2_k127_8061113_6 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.000000002747 69.0
HKD2_k127_8061113_7 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03769,K03770 - 5.2.1.8 0.000003583 59.0
HKD2_k127_8064124_0 pfkB family carbohydrate kinase K18478 - 2.7.1.184 0.000000000000000000000000000000000000000000000000000000000000001245 231.0
HKD2_k127_8067719_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 470.0
HKD2_k127_8067719_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000001301 233.0
HKD2_k127_8067719_2 including yeast histone deacetylase and acetoin utilization protein - - - 0.0000000000000000000000000000000001914 144.0
HKD2_k127_8067719_3 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000002083 87.0
HKD2_k127_8067719_4 Ribosomal protein L34 K02914 - - 0.000000000001497 76.0
HKD2_k127_8067719_5 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.000000000884 66.0
HKD2_k127_8067719_6 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000001918 61.0
HKD2_k127_8068962_0 Magnesium chelatase, subunit ChlI K03404,K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002796 339.0
HKD2_k127_8068962_1 THUMP K07444,K12297 - 2.1.1.173,2.1.1.264 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002626 278.0
HKD2_k127_8068962_2 family UPF0066 K01628 - 4.1.2.17 0.0000000000000000000000000000002866 131.0
HKD2_k127_8071979_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 413.0
HKD2_k127_8071979_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001862 329.0
HKD2_k127_8071979_2 Preprotein translocase subunit K03210 - - 0.0000000000000000000000000001411 119.0
HKD2_k127_8071979_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.0000000000000000000000005382 111.0
HKD2_k127_8085436_0 Belongs to the glycosyl hydrolase 13 family K01214 - 3.2.1.68 5.507e-284 894.0
HKD2_k127_8085436_1 Belongs to the peptidase M16 family K07263 - - 0.000000000000000000000000000000000000000000000000009412 196.0
HKD2_k127_8085436_2 PFAM Nucleoside recognition - - - 0.0000000000000000000001126 110.0
HKD2_k127_8085436_3 Nucleoside recognition - - - 0.0000000000000000000001543 110.0
HKD2_k127_8098344_0 PFAM Extracellular ligand-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007493 341.0
HKD2_k127_8098344_1 Belongs to the binding-protein-dependent transport system permease family K11960 - - 0.000000000000000000000000000000000000000000000001878 196.0
HKD2_k127_8141985_0 PFAM Cytochrome c oxidase, subunit I K04561 - 1.7.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007793 449.0
HKD2_k127_8141985_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000353 300.0
HKD2_k127_8141985_2 - - - - 0.00000000000000000000000000000000000000000000003639 175.0
HKD2_k127_8141985_3 AraC-like ligand binding domain - - - 0.00000000000000000000000001495 112.0
HKD2_k127_8141985_4 2-Nitropropane dioxygenase - - - 0.0000000000000000001145 95.0
HKD2_k127_8164447_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0003674,GO:0003824,GO:0003906,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000004322 231.0
HKD2_k127_8164447_1 L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - 0.00001153 49.0
HKD2_k127_8183712_0 Rod shape-determining protein K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 511.0
HKD2_k127_8183712_1 Penicillin-binding protein, dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 492.0
HKD2_k127_8183712_10 Nuclease (SNase domain protein) K01174 - 3.1.31.1 0.0000000000000000001114 101.0
HKD2_k127_8183712_11 Thioredoxin-like - - - 0.0003691 51.0
HKD2_k127_8183712_2 peptidyl-lysine modification to peptidyl-hypusine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000409 341.0
HKD2_k127_8183712_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007866 319.0
HKD2_k127_8183712_4 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000002032 212.0
HKD2_k127_8183712_5 SurA N-terminal domain K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000003757 209.0
HKD2_k127_8183712_6 Belongs to the UPF0173 family - - - 0.00000000000000000000000000000000000000000000006803 172.0
HKD2_k127_8183712_7 Involved in formation and maintenance of cell shape K03570 - - 0.00000000000000000000000000000000000000001087 164.0
HKD2_k127_8183712_8 CoA binding domain K06929 - - 0.0000000000000000000000000000000000000008758 151.0
HKD2_k127_8183712_9 Belongs to the thioredoxin family K03671 - - 0.00000000000000000000000000000001742 134.0
HKD2_k127_8215480_0 Carbamoyl-phosphate synthetase large chain domain protein K01959,K01961 - 6.3.4.14,6.4.1.1,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000215 588.0
HKD2_k127_8215480_1 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005198 265.0
HKD2_k127_8215480_2 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000005958 259.0
HKD2_k127_8215480_3 Creatinase/Prolidase N-terminal domain K01262,K01271 - 3.4.11.9,3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000532 252.0
HKD2_k127_8215480_4 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000002718 168.0
HKD2_k127_8215480_5 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000000000000239 140.0
HKD2_k127_8215480_6 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.00000000000001068 78.0
HKD2_k127_8215480_7 Roadblock/LC7 domain - - - 0.00000000263 64.0
HKD2_k127_8215480_8 Tetratricopeptide repeats - - - 0.00004105 55.0
HKD2_k127_8215719_0 Protein of unknown function (DUF815) K06923 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 346.0
HKD2_k127_8215719_1 Dynamin family - - - 0.00000000000000000000000000000000000000000000000000000000000002249 232.0
HKD2_k127_8215719_2 with different specificities (related to short-chain alcohol K00034,K00046,K00059 - 1.1.1.100,1.1.1.47,1.1.1.69 0.0000000000000000000000000000000000000000000000000345 179.0
HKD2_k127_8215719_3 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425 - 0.0000000000000000000000000000000000000000000000003601 180.0
HKD2_k127_8215719_4 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000000000000000000001599 170.0
HKD2_k127_8235925_0 PFAM histone deacetylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001273 270.0
HKD2_k127_8235925_1 Bacterial capsule synthesis protein PGA_cap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005687 259.0
HKD2_k127_8235925_2 LysM domain K01449,K19223 - 3.5.1.28 0.00000000000000000000000000000000000000000000003672 183.0
HKD2_k127_8248660_0 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.00000000003162 74.0
HKD2_k127_8248660_1 Diguanylate cyclase K21023 - 2.7.7.65 0.000001481 61.0
HKD2_k127_8248660_2 Probable molybdopterin binding domain - - - 0.00006711 46.0
HKD2_k127_8256271_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703,K20452 - 4.2.1.33,4.2.1.35,4.2.1.85 4.169e-196 620.0
HKD2_k127_8256271_1 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 517.0
HKD2_k127_8256271_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 512.0
HKD2_k127_8256271_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002017 279.0
HKD2_k127_8256271_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000002072 244.0
HKD2_k127_8256271_5 TIGRFAM Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000001526 223.0
HKD2_k127_8256271_6 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.000000000000000000000000000000000000000000000001433 194.0
HKD2_k127_8256271_7 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000006972 62.0
HKD2_k127_8321389_0 Acetamidase/Formamidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 413.0
HKD2_k127_842621_0 ATPase BadF BadG BcrA BcrD type - - - 1.166e-310 988.0
HKD2_k127_842621_1 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007858 371.0
HKD2_k127_842621_2 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000002987 219.0
HKD2_k127_842621_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000008766 170.0
HKD2_k127_842621_4 PFAM glycosyl transferase family 51 K05366 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000284 149.0
HKD2_k127_842621_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000000000000001362 89.0
HKD2_k127_842621_6 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.00000000000000001755 83.0
HKD2_k127_842621_7 TIGRFAM MJ0042 family finger-like protein - - - 0.00000000000003165 86.0
HKD2_k127_842621_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.0000000002083 73.0
HKD2_k127_8433556_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 9.007e-208 676.0
HKD2_k127_8433556_1 Belongs to the ALAD family K01698 GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 467.0
HKD2_k127_8433556_2 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000002156 201.0
HKD2_k127_8433556_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000007044 123.0
HKD2_k127_8433556_4 Uroporphyrinogen-III synthase HemD K01719 - 4.2.1.75 0.00000000000000000002404 97.0
HKD2_k127_8433556_5 - - - - 0.000000000000000005203 89.0
HKD2_k127_8433556_7 - - - - 0.00000000001234 75.0
HKD2_k127_8445746_0 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 630.0
HKD2_k127_8445746_1 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 614.0
HKD2_k127_8445746_2 quinone binding K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007662 354.0
HKD2_k127_8445746_3 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00336 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 341.0
HKD2_k127_8445746_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000000000003233 177.0
HKD2_k127_8445746_5 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000007588 128.0
HKD2_k127_8445746_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.00000000000000000000000007325 110.0
HKD2_k127_8445746_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000005857 82.0
HKD2_k127_8464145_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K00344,K00966,K01840,K03431,K15778,K16881 - 1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8 2.995e-280 884.0
HKD2_k127_8464145_1 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 407.0
HKD2_k127_8464145_10 PFAM aminotransferase, class I and II K00812 - 2.6.1.1 0.000000000004877 66.0
HKD2_k127_8464145_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004804 389.0
HKD2_k127_8464145_3 PFAM Band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 361.0
HKD2_k127_8464145_4 SMART PUA domain containing protein K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000002046 283.0
HKD2_k127_8464145_5 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000008667 224.0
HKD2_k127_8464145_6 LysE type translocator - - - 0.000000000000000000000000000000000000000000000000000001123 200.0
HKD2_k127_8464145_7 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000008177 218.0
HKD2_k127_8464145_8 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000817 175.0
HKD2_k127_8464145_9 Stage II sporulation protein K06381 - - 0.000000000000000000000000000000000000000000001515 182.0
HKD2_k127_8519526_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002231 322.0
HKD2_k127_8519526_1 Transcriptional regulatory protein, C terminal K07658 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003945 247.0
HKD2_k127_8519526_2 Diacylglycerol kinase catalytic domain (presumed) - - - 0.000000000000000000000000000000000000001389 158.0
HKD2_k127_8519526_3 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0002251 51.0
HKD2_k127_8529610_0 SMART Elongator protein 3 MiaB NifB K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 538.0
HKD2_k127_8529610_1 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 467.0
HKD2_k127_8529610_2 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009207 426.0
HKD2_k127_8529610_3 CorA-like Mg2+ transporter protein K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003078 347.0
HKD2_k127_8529610_4 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007754 327.0
HKD2_k127_8529610_5 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 329.0
HKD2_k127_8529610_6 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008375 283.0
HKD2_k127_8529610_7 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000003929 280.0
HKD2_k127_8540685_0 sigma-54 factor interaction domain-containing protein K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 391.0
HKD2_k127_8540685_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000001564 84.0
HKD2_k127_8584413_0 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 574.0
HKD2_k127_8584413_1 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000272 131.0
HKD2_k127_8603573_0 PFAM Integral membrane protein TerC K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 325.0
HKD2_k127_8603573_1 Cytidylate kinase-like family - - - 0.00000000000000000000000000000000000000000000000002851 189.0
HKD2_k127_8603573_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.000000000009615 76.0
HKD2_k127_8622844_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000682 102.0
HKD2_k127_8680160_0 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 353.0
HKD2_k127_8680160_1 Glycine zipper - - - 0.00000000000000000000000000000000000000000000000000000000000000000000131 243.0
HKD2_k127_8688008_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 7.562e-262 824.0
HKD2_k127_8688008_1 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000001609 183.0
HKD2_k127_8688008_2 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000704 160.0
HKD2_k127_8688008_3 Belongs to the bacterial ribosomal protein bL28 family K02902 GO:0003674,GO:0003735,GO:0005198 - 0.000000000000000000001111 95.0
HKD2_k127_8688008_4 YicC domain protein - - - 0.0000000000000001211 81.0
HKD2_k127_8688008_5 DUF218 domain - - - 0.00000000000001506 81.0
HKD2_k127_8688008_6 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000002144 75.0
HKD2_k127_876261_0 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004036 501.0
HKD2_k127_876261_1 acyl-coa dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 389.0
HKD2_k127_876261_2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 321.0
HKD2_k127_876261_3 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 305.0
HKD2_k127_876261_4 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids K19221 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000007158 200.0
HKD2_k127_876261_5 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 0.0000000000000000000000000000000000009979 141.0
HKD2_k127_877111_0 ABC transporter, ATP-binding protein K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004601 370.0
HKD2_k127_877111_1 ABC-2 type transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 283.0
HKD2_k127_8783333_0 PFAM Phosphomethylpyrimidine kinase type-1 K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007992 301.0
HKD2_k127_8783333_1 Protein of unknown function (DUF520) K09767 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002997 259.0
HKD2_k127_8783333_2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000004469 261.0
HKD2_k127_8783333_3 transcription activator K03707 - 3.5.99.2 0.00000000000000000000000000000000000000000000000000000000000001279 231.0
HKD2_k127_8783333_4 Chorismate mutase K03856,K04092,K04093,K04516,K13853 - 2.5.1.54,5.4.99.5 0.000000000000000000000000000000000000002714 147.0
HKD2_k127_8885056_0 Single cache domain 3 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002078 335.0
HKD2_k127_8885056_1 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000002063 172.0
HKD2_k127_8885056_2 Membrane - - - 0.00000000000000000000000000000000000000000001914 168.0
HKD2_k127_8923250_0 MmgE PrpD family protein K01720 - 4.2.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 555.0
HKD2_k127_8923250_1 (2R)-phospho-3-sulfolactate synthase (ComA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 423.0
HKD2_k127_8923250_2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 426.0
HKD2_k127_8923250_3 Rossmann fold nucleotide-binding protein K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001658 345.0
HKD2_k127_8923250_4 PFAM thiamine pyrophosphate protein domain protein TPP-binding K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005257 325.0
HKD2_k127_8923250_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000001214 215.0
HKD2_k127_8923250_6 PAS sensor protein - - - 0.0000000000000000000000000000000000000000000001534 174.0
HKD2_k127_8923250_7 PFAM Cyclic nucleotide-binding K10914,K21563 - - 0.0000000000000000000000000000000001132 141.0
HKD2_k127_8945372_0 Transglycosylase K05366,K21464 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 454.0
HKD2_k127_8945372_2 Member of the two-component regulatory system ZraS ZraR. May function as a membrane-associated protein kinase that phosphorylates ZraR in response to high concentrations of zinc or lead in the medium K07709 GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010043,GO:0010288,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071241,GO:0071248,GO:0071284,GO:0071294,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 0.0007844 42.0
HKD2_k127_8966080_0 fructose-bisphosphate aldolase activity K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002253 399.0
HKD2_k127_8966080_1 Aminotransferase K00812,K22457 GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297 2.6.1.1,2.6.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009046 319.0
HKD2_k127_8966080_2 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000000000000000000001157 213.0
HKD2_k127_8966080_3 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000372 193.0
HKD2_k127_8966080_4 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000000000000000000000000000008702 158.0
HKD2_k127_8966080_5 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000002865 142.0
HKD2_k127_8966080_6 Domain of unknown function (DUF1858) - - - 0.00000000000000000004018 91.0
HKD2_k127_9008947_0 Bacterial extracellular solute-binding protein K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 403.0
HKD2_k127_9008947_1 Chromate transporter K07240 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 372.0
HKD2_k127_9008947_2 Binding-protein-dependent transport system inner membrane component K05773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006072 316.0
HKD2_k127_9008947_3 ABC transporter K02017,K06857 - 3.6.3.29,3.6.3.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 332.0
HKD2_k127_9008947_4 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000703 225.0
HKD2_k127_9008947_5 PFAM D-galactarate dehydratase Altronate hydrolase domain protein K01685,K01708,K16846 - 4.2.1.42,4.2.1.7,4.4.1.24 0.00000000000000000000000000000000000000000000000000002585 188.0
HKD2_k127_9008947_6 Tetratricopeptide repeat - - - 0.000000000000000000000000000005971 137.0
HKD2_k127_9008947_7 Flavin containing amine oxidoreductase - - - 0.0009675 52.0
HKD2_k127_9010927_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 5.071e-294 933.0
HKD2_k127_9010927_1 acyl-CoA transferases carnitine dehydratase - - - 2.365e-211 664.0
HKD2_k127_9010927_10 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000004412 79.0
HKD2_k127_9010927_2 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005789 581.0
HKD2_k127_9010927_3 MoeA domain protein domain I and II K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 510.0
HKD2_k127_9010927_4 L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005347 410.0
HKD2_k127_9010927_5 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 GO:0003674,GO:0003824,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 422.0
HKD2_k127_9010927_6 Transcriptional regulator, ModE family K02019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000178 289.0
HKD2_k127_9010927_7 Zinc-binding dehydrogenase K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000006879 261.0
HKD2_k127_9010927_8 PFAM MOSC domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000216 228.0
HKD2_k127_9010927_9 ThiS family - - - 0.000000000000000000309 91.0
HKD2_k127_9023594_0 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000000000000004715 244.0
HKD2_k127_9023594_1 PFAM metal-dependent phosphohydrolase HD sub domain - - - 0.00000000000000000000000000000000000000000000000000000000000002128 225.0
HKD2_k127_9023594_2 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000000000002401 131.0
HKD2_k127_9023594_3 Cyclic nucleotide-monophosphate binding domain - - - 0.0000003777 59.0
HKD2_k127_9023723_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007478 554.0
HKD2_k127_9023723_1 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008784 289.0
HKD2_k127_9164860_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000373 554.0
HKD2_k127_9164860_1 Alpha beta hydrolase - - - 0.0000000000000000000004285 102.0
HKD2_k127_9171925_0 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000001422 276.0
HKD2_k127_9171925_1 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000017 239.0
HKD2_k127_9171925_2 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.000000000000000000000000000000000000001631 169.0
HKD2_k127_9204471_0 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005614 433.0
HKD2_k127_9204471_1 PFAM CBS domain K04767 - - 0.00000000000000000000000000000000005252 142.0
HKD2_k127_9204471_2 Histone deacetylase domain - - - 0.000000000000000000000000000000001435 132.0
HKD2_k127_9213127_0 Thiamine biosynthesis protein (ThiI) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004793 337.0
HKD2_k127_9213127_1 ThiF family K03148,K21147 - 2.7.7.73,2.7.7.80,2.8.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000261 256.0
HKD2_k127_9213127_2 PFAM asparagine synthase K06864 - - 0.00000000000000000000000000000000000000000000000000132 188.0
HKD2_k127_9213127_3 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.0000003954 53.0
HKD2_k127_9213585_0 H( )-stimulated, divalent metal cation uptake system K03322 - - 2.508e-219 701.0
HKD2_k127_9213585_1 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020,K00042,K18121 - 1.1.1.31,1.1.1.60,1.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000009566 245.0
HKD2_k127_9213585_2 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000002081 204.0
HKD2_k127_9213585_3 helix_turn_helix, cAMP Regulatory protein K01420,K21563 - - 0.000000000000000000000000000000000000000000000000001073 191.0
HKD2_k127_9213585_4 PFAM amino acid-binding ACT domain protein K03567 - - 0.000000000000000000000000000000000000000000001019 172.0
HKD2_k127_9213585_5 signal transduction histidine kinase K02668,K07709 - 2.7.13.3 0.0000000000000000000000001906 111.0
HKD2_k127_9213585_6 Signal transduction histidine kinase - - - 0.000000000000000003646 86.0
HKD2_k127_9213585_7 SMART Tetratricopeptide - - - 0.000000000004239 78.0
HKD2_k127_923402_0 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 361.0
HKD2_k127_923402_1 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007803 297.0
HKD2_k127_923402_2 Psort location Cytoplasmic, score - - - 0.000000000000000000000000000001038 130.0
HKD2_k127_9267208_0 PFAM Aminotransferase class I and II K11358 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001883 416.0
HKD2_k127_9267208_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000612 348.0
HKD2_k127_9267208_2 response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004522 276.0
HKD2_k127_9267208_3 Zincin-like metallopeptidase - - - 0.000000000000000000003143 103.0
HKD2_k127_9279675_0 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.0000000000000000000000000000000000000000001628 174.0
HKD2_k127_9279675_1 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000001634 103.0
HKD2_k127_9330342_0 Heavy metal translocating P-type atpase K01534 - 3.6.3.3,3.6.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004463 602.0
HKD2_k127_9330342_1 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.00000000000000000000000000000000000003245 146.0
HKD2_k127_9330342_2 sister chromatid segregation - - - 0.00000000000000000000000000008733 119.0
HKD2_k127_9330342_3 Cytochrome C assembly protein - - - 0.0000000000000003914 83.0
HKD2_k127_9381960_0 Peptidase dimerisation domain K12941 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001454 355.0
HKD2_k127_9381960_1 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000000000000000000000000000000002234 219.0
HKD2_k127_9381960_2 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000000000000000000000000000005583 179.0
HKD2_k127_9381960_3 RDD family - - - 0.00000000000000000001258 99.0
HKD2_k127_9389885_0 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 341.0
HKD2_k127_9389885_1 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 347.0
HKD2_k127_9389885_2 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001761 284.0
HKD2_k127_9389885_3 Ribosome recycling factor K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000003466 218.0
HKD2_k127_9389885_4 PFAM phosphatidate cytidylyltransferase K00981 - 2.7.7.41 0.00000000000000000000000000000000000006198 153.0
HKD2_k127_9406076_0 PFAM Glycosyl transferases group 1 K13057 - 2.4.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 549.0
HKD2_k127_9406076_1 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 359.0
HKD2_k127_9406076_2 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000001658 179.0
HKD2_k127_9406076_3 trehalose biosynthetic process K01087 - 3.1.3.12 0.000000000000000000000000000000000000000000001323 173.0
HKD2_k127_9406076_4 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000001005 116.0
HKD2_k127_9433255_0 sulphate transporter - - - 9.76e-213 674.0
HKD2_k127_9433255_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000007911 227.0
HKD2_k127_9433255_2 Outer membrane protein beta-barrel domain - - - 0.0000000000000000000004093 109.0
HKD2_k127_9433255_3 Transport permease protein K01992 - - 0.00000002262 55.0
HKD2_k127_9467039_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 5.502e-286 888.0
HKD2_k127_9467039_1 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000000000000000000000000000000000000005394 252.0
HKD2_k127_9467039_2 Cold shock protein K03704 - - 0.0008535 47.0
HKD2_k127_9473355_0 AAA family ATPase, CDC48 subfamily - - - 1.084e-226 725.0
HKD2_k127_9473355_1 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.0000000000000000000000000000000000000000000000000000000007404 205.0
HKD2_k127_9600198_0 Peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 395.0
HKD2_k127_9600198_1 SNARE associated Golgi protein K01077 - 3.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009222 299.0
HKD2_k127_9630876_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 603.0
HKD2_k127_9630876_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 460.0
HKD2_k127_9630876_2 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.000000000000000000000000000000000000000000005534 183.0
HKD2_k127_9639158_0 PFAM extracellular solute-binding protein, family 5 K02035,K13893 - - 8.268e-225 714.0
HKD2_k127_9639158_1 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 444.0
HKD2_k127_9639158_2 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 407.0
HKD2_k127_9639158_3 Belongs to the ABC transporter superfamily K02031,K12371,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006171 321.0
HKD2_k127_9664933_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009208 619.0
HKD2_k127_9664933_1 Cupin domain - - - 0.000001696 50.0
HKD2_k127_9679659_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 1.226e-203 647.0
HKD2_k127_9679659_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 8.634e-198 627.0
HKD2_k127_9679659_2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000003136 214.0
HKD2_k127_9679659_3 Domain of unknown function (DUF4124) K08309 - - 0.00000000000000000000000000000000000000000000002892 176.0
HKD2_k127_9679659_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000226 167.0
HKD2_k127_9679659_5 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000001578 115.0
HKD2_k127_9679659_6 - - - - 0.0000000000002324 78.0
HKD2_k127_9763923_0 Belongs to the CarB family K01955 - 6.3.5.5 1.444e-241 764.0
HKD2_k127_9763923_1 radical SAM domain protein K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000001108 239.0
HKD2_k127_9794929_0 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008267 473.0
HKD2_k127_9794929_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005956 453.0
HKD2_k127_9794929_2 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 394.0
HKD2_k127_9794929_3 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.000000000000000000000000000000000000000000000000000000000006138 214.0
HKD2_k127_9794929_4 radical SAM domain protein K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000001047 214.0
HKD2_k127_9794929_5 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000002388 77.0
HKD2_k127_9918339_0 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008334 603.0
HKD2_k127_9918339_1 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 468.0
HKD2_k127_9918339_2 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004448 371.0
HKD2_k127_9918339_3 6-phosphogluconolactonase K00851,K01057 - 2.7.1.12,3.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000003044 251.0
HKD2_k127_9918339_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000000000821 188.0
HKD2_k127_9940663_0 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 381.0
HKD2_k127_9940663_1 Lytic transglycosylase, SLT, LysM and LysM domain-containing K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 317.0
HKD2_k127_9941448_0 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000001222 245.0
HKD2_k127_9941448_1 PFAM regulatory protein TetR K13770 - - 0.00000000000000000000000000000000000000000000000000006725 193.0
HKD2_k127_9941448_2 Transcriptional regulator IclR - - - 0.000000000000000000000000002842 113.0
HKD2_k127_99520_0 Fructose-1,6-bisphosphatase K01622 - 3.1.3.11,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009314 574.0
HKD2_k127_99520_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 502.0
HKD2_k127_99520_10 - - - - 0.0000002052 55.0
HKD2_k127_99520_2 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 417.0
HKD2_k127_99520_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 404.0
HKD2_k127_99520_4 Male sterility protein K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 345.0
HKD2_k127_99520_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004623 318.0
HKD2_k127_99520_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 293.0
HKD2_k127_99520_7 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007555 291.0
HKD2_k127_99520_8 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000004067 252.0
HKD2_k127_99520_9 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000117 171.0
HKD2_k127_9995936_0 PFAM Xylulose 5-phosphate Fructose 6-phosphate phosphoketolase, N-terminal K01621 GO:0003674,GO:0003824,GO:0008150,GO:0009758 4.1.2.22,4.1.2.9 4.502e-275 856.0
HKD2_k127_9995936_1 GPR1 FUN34 yaaH family K07034 - - 0.0000000000000000000000000000006758 131.0
HKD2_k127_9995936_2 Protein of unknown function, DUF488 - - - 0.0000000000006775 77.0