logo

Overview

ID MAG01791
Name HKD2_bin.33
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Thermoanaerobaculia
Order UBA5066
Family UBA5066
Genus
Species
Assembly information
Completeness (%) 95.83
Contamination (%) 1.62
GC content (%) 71.0
N50 (bp) 43,518
Genome size (bp) 3,936,041

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3096

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10053792_0 Belongs to the PEP-utilizing enzyme family K01007 - 2.7.9.2 1e-322 1012.0
HKD2_k127_10053792_1 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 3.225e-296 919.0
HKD2_k127_10053792_10 Dehydrogenase K00248,K09478 - 1.3.8.1,1.3.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 462.0
HKD2_k127_10053792_11 Serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002133 462.0
HKD2_k127_10053792_12 protein-disulfide reductase activity K04084,K06196 - 1.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 430.0
HKD2_k127_10053792_13 amino acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009389 394.0
HKD2_k127_10053792_14 carbamoyl transferase, NodU family K00612 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008711 319.0
HKD2_k127_10053792_15 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006941 287.0
HKD2_k127_10053792_16 ABC transporter permease K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000161 280.0
HKD2_k127_10053792_17 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000001593 229.0
HKD2_k127_10053792_18 RNA polymerase, sigma-24 subunit, ECF subfamily K02405 - - 0.00000000000000000000000000000000000000000000000000000000001539 212.0
HKD2_k127_10053792_19 ECF sigma factor - - - 0.000000000000000000000000000000000000000000000000000000007526 204.0
HKD2_k127_10053792_2 glutamate dehydrogenase [NAD(P)+] activity K00260,K00261,K00262 GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 9.351e-227 709.0
HKD2_k127_10053792_20 PFAM diacylglycerol kinase catalytic region - - - 0.0000000000000000000000000000000000000000000007564 186.0
HKD2_k127_10053792_21 - - - - 0.0000000000000000000000000000000000000000007695 160.0
HKD2_k127_10053792_22 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.000000000000000000000000000000000000000002234 165.0
HKD2_k127_10053792_23 Short-chain dehydrogenase reductase sdr - - - 0.0000000000000000000000000000000000000001119 172.0
HKD2_k127_10053792_24 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000000000000005648 151.0
HKD2_k127_10053792_25 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.0000000000000000000000000000000000009426 161.0
HKD2_k127_10053792_26 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000004276 137.0
HKD2_k127_10053792_27 Involved in the tonB-independent uptake of proteins - GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019586,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046397,GO:0071704,GO:0072329,GO:1901575 - 0.000000000000000000000000000002337 135.0
HKD2_k127_10053792_28 Fumble K09680 - 2.7.1.33 0.0000000000000000000000005572 121.0
HKD2_k127_10053792_29 Domain of unknown function (DUF4136) - - - 0.000000000000000000003507 100.0
HKD2_k127_10053792_3 oxoglutarate dehydrogenase (succinyl-transferring) activity K00164,K01616 GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 5.613e-221 706.0
HKD2_k127_10053792_30 oxidoreductase activity - - - 0.0000000000000000009159 101.0
HKD2_k127_10053792_31 - - - - 0.000000000000000002443 101.0
HKD2_k127_10053792_32 - - - - 0.00000000001997 78.0
HKD2_k127_10053792_33 2Fe-2S -binding domain - - - 0.0000000005194 69.0
HKD2_k127_10053792_34 Thioredoxin-like - - - 0.00001032 57.0
HKD2_k127_10053792_36 - - - - 0.0001275 53.0
HKD2_k127_10053792_4 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003872 613.0
HKD2_k127_10053792_5 6-phosphofructokinase activity K00850,K00895,K21071 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008523 593.0
HKD2_k127_10053792_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378,K13380 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005763 528.0
HKD2_k127_10053792_7 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 511.0
HKD2_k127_10053792_8 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008507 510.0
HKD2_k127_10053792_9 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008159 497.0
HKD2_k127_1295084_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000377 426.0
HKD2_k127_1295084_1 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 317.0
HKD2_k127_1295084_2 Cytidine monophosphokinase K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000926 262.0
HKD2_k127_1295084_3 prephenate dehydrogenase K04517,K14170,K14187 - 1.3.1.12,4.2.1.51,5.4.99.5 0.00000000000000000000000000001399 131.0
HKD2_k127_1295084_4 TM2 domain - - - 0.0000000000000000000002126 104.0
HKD2_k127_1295084_5 tetratricopeptide repeat - - - 0.00006274 54.0
HKD2_k127_1297676_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1196.0
HKD2_k127_1297676_1 Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - 7.216e-199 629.0
HKD2_k127_1297676_10 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 342.0
HKD2_k127_1297676_11 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004488 336.0
HKD2_k127_1297676_12 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016070,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 308.0
HKD2_k127_1297676_13 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 306.0
HKD2_k127_1297676_14 ABC transporter, permease protein K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003366 265.0
HKD2_k127_1297676_15 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000004835 272.0
HKD2_k127_1297676_16 pfam abc K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000001094 256.0
HKD2_k127_1297676_17 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000002493 267.0
HKD2_k127_1297676_18 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000003639 250.0
HKD2_k127_1297676_19 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000003185 233.0
HKD2_k127_1297676_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 640.0
HKD2_k127_1297676_20 ABC-type transport system involved in resistance to organic solvents periplasmic component K02067 - - 0.00000000000000000000000000000000000000000000000000000000001028 232.0
HKD2_k127_1297676_21 MotA TolQ ExbB proton channel K03561,K03562 - - 0.00000000000000000000000000000000000000000000000000000000397 207.0
HKD2_k127_1297676_22 riboflavin synthase, alpha subunit K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000007746 192.0
HKD2_k127_1297676_23 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000002075 203.0
HKD2_k127_1297676_24 Bacterial transferase hexapeptide (six repeats) - - - 0.000000000000000000000000000000000000000000000002329 181.0
HKD2_k127_1297676_25 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000002644 178.0
HKD2_k127_1297676_26 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.00000000000000000000000000000000000000000363 166.0
HKD2_k127_1297676_27 exo-alpha-(2->6)-sialidase activity - - - 0.000000000000000000000000000000000000002588 171.0
HKD2_k127_1297676_28 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000193 142.0
HKD2_k127_1297676_29 biopolymer transport protein K03559,K03560 - - 0.00000000000000000000009521 103.0
HKD2_k127_1297676_3 2-oxoglutarate dehydrogenase, E1 K00164 - 1.2.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 582.0
HKD2_k127_1297676_30 Tetratricopeptide repeat - - - 0.0000000000000000000002447 108.0
HKD2_k127_1297676_31 Biopolymer transport protein ExbD/TolR K03559,K03560 - - 0.000000000000000000002649 99.0
HKD2_k127_1297676_32 Metallo-beta-lactamase superfamily K05555 - - 0.0000000000000000001544 103.0
HKD2_k127_1297676_33 - - - - 0.000000000000000003633 89.0
HKD2_k127_1297676_34 PKD domain containing protein K01179,K07004,K13277,K20276,K21449 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 3.2.1.4 0.000000000000000003649 101.0
HKD2_k127_1297676_35 TPR repeat-containing protein - - - 0.0000000119 68.0
HKD2_k127_1297676_36 - - - - 0.000002397 62.0
HKD2_k127_1297676_4 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003786 447.0
HKD2_k127_1297676_5 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 399.0
HKD2_k127_1297676_6 PFAM SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 367.0
HKD2_k127_1297676_7 Replicative DNA helicase K02314 GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 375.0
HKD2_k127_1297676_8 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 374.0
HKD2_k127_1297676_9 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 355.0
HKD2_k127_1313046_0 Pyruvate ferredoxin/flavodoxin oxidoreductase K00187 - 1.2.7.7 1.366e-227 716.0
HKD2_k127_1313046_1 Cytochrome c3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 402.0
HKD2_k127_1313046_11 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000001173 107.0
HKD2_k127_1313046_12 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000001889 116.0
HKD2_k127_1313046_13 Pyruvate:ferredoxin oxidoreductase core domain II K00186 - 1.2.7.7 0.00000000000000000000001408 101.0
HKD2_k127_1313046_14 signal sequence binding K07152 - - 0.0000000000000000002683 98.0
HKD2_k127_1313046_17 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000341 52.0
HKD2_k127_1313046_18 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0006645 53.0
HKD2_k127_1313046_2 Phospholipase D. Active site motifs. K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005523 370.0
HKD2_k127_1313046_3 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 353.0
HKD2_k127_1313046_4 PFAM sugar isomerase (SIS) K00820 - 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009463 318.0
HKD2_k127_1313046_5 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 305.0
HKD2_k127_1313046_6 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001472 294.0
HKD2_k127_1313046_7 CHAT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004773 289.0
HKD2_k127_1313046_8 PFAM NHL repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000006432 238.0
HKD2_k127_1313046_9 metalloendopeptidase activity K03799 - - 0.000000000000000000000000000000000001782 152.0
HKD2_k127_1323909_0 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 433.0
HKD2_k127_1323909_1 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000009832 232.0
HKD2_k127_1350454_0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 634.0
HKD2_k127_1350454_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003049 588.0
HKD2_k127_1350454_10 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 340.0
HKD2_k127_1350454_11 Acetamidase formamidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005511 348.0
HKD2_k127_1350454_12 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 339.0
HKD2_k127_1350454_13 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003834 301.0
HKD2_k127_1350454_14 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000000000000000000000000000009591 259.0
HKD2_k127_1350454_15 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2 K02806 - - 0.000000000000000000000000000000000000000000000000000000000007966 214.0
HKD2_k127_1350454_16 hydrogenase 4 membrane K12140 - - 0.00000000000000000000000000000000000000000000000000000000001646 212.0
HKD2_k127_1350454_17 domain, Protein K01729,K09942 - 4.2.2.3 0.00000000000000000000000000000000000000000000000000007213 207.0
HKD2_k127_1350454_18 - - - - 0.000000000000000000000000000000000000000000000002443 198.0
HKD2_k127_1350454_19 Rhomboid family - - - 0.0000000000000000003932 103.0
HKD2_k127_1350454_2 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005076 582.0
HKD2_k127_1350454_20 DNA-binding protein PTS system, IIA component K02806 - - 0.000000000002887 76.0
HKD2_k127_1350454_21 surface antigen - - - 0.0001269 48.0
HKD2_k127_1350454_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004757 535.0
HKD2_k127_1350454_4 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 540.0
HKD2_k127_1350454_5 PFAM NADH Ubiquinone plastoquinone (complex I) K12137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 540.0
HKD2_k127_1350454_6 Proton-conducting membrane transporter K12141 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 507.0
HKD2_k127_1350454_7 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006908 366.0
HKD2_k127_1350454_8 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 347.0
HKD2_k127_1350454_9 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003441 343.0
HKD2_k127_1470553_0 Dehydrogenase E1 component K11381 - 1.2.4.4 1.77e-314 980.0
HKD2_k127_1470553_1 deca-heme c-type cytochrome - - - 2.586e-207 669.0
HKD2_k127_1470553_10 Carbonic anhydrase K01673 - 4.2.1.1 0.000000000000000000000000000000000000000000000000000000000000834 218.0
HKD2_k127_1470553_11 Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB K16092 GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0006810,GO:0006811,GO:0008150,GO:0015075,GO:0015267,GO:0015318,GO:0015889,GO:0015893,GO:0016020,GO:0016021,GO:0019904,GO:0022803,GO:0022838,GO:0022857,GO:0031224,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0055085,GO:0071702,GO:0071705 - 0.0000000000000000000000000000000000000000000000000003603 208.0
HKD2_k127_1470553_12 Sortase family K07284 - 3.4.22.70 0.0000000000000000000000000000000000000000000000001586 194.0
HKD2_k127_1470553_13 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity - - - 0.00000000000000000000000000000000000000000003487 168.0
HKD2_k127_1470553_14 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000006571 151.0
HKD2_k127_1470553_15 Domain of unknown function (DUF4136) - - - 0.00000000000000000000000000000006015 134.0
HKD2_k127_1470553_16 YMGG-like Gly-zipper - - - 0.0000000000000000000000000002018 121.0
HKD2_k127_1470553_17 Domain of unknown function (DUF4136) - - - 0.000000000000000000000000007069 117.0
HKD2_k127_1470553_18 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.000000000000000000000000008184 113.0
HKD2_k127_1470553_2 Acyl-CoA dehydrogenase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 536.0
HKD2_k127_1470553_20 - - - - 0.000000000000000000002857 101.0
HKD2_k127_1470553_21 palmitoyl-(protein) hydrolase activity K06999 - - 0.000000000004449 79.0
HKD2_k127_1470553_22 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000007536 70.0
HKD2_k127_1470553_23 - K01992 - - 0.00000008022 65.0
HKD2_k127_1470553_25 Hsp20/alpha crystallin family K13993 - - 0.0002469 51.0
HKD2_k127_1470553_3 Bacterial protein of unknown function (DUF885) K01322 - 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007156 516.0
HKD2_k127_1470553_4 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 505.0
HKD2_k127_1470553_5 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 501.0
HKD2_k127_1470553_6 major pilin protein fima - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 448.0
HKD2_k127_1470553_7 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 319.0
HKD2_k127_1470553_8 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001011 286.0
HKD2_k127_1470553_9 PFAM RNA binding S1 domain protein K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003572 293.0
HKD2_k127_1514524_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 5.86e-241 770.0
HKD2_k127_1514524_1 Cytochrome bd terminal oxidase subunit I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008777 334.0
HKD2_k127_1514524_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 324.0
HKD2_k127_1514524_3 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003938 249.0
HKD2_k127_1514524_4 Cytochrome c oxidase subunit K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000003158 204.0
HKD2_k127_1514524_5 oxidase subunit - - - 0.00000000000000000000000000000001713 140.0
HKD2_k127_1514524_6 ribonuclease - - - 0.0000000000000000000000000000007873 126.0
HKD2_k127_1514524_7 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000003795 132.0
HKD2_k127_1514524_8 Heme copper-type cytochrome quinol oxidase subunit 3 K02276 - 1.9.3.1 0.00000000000000000001877 102.0
HKD2_k127_1514524_9 Barstar (barnase inhibitor) - - - 0.000000000000000001648 95.0
HKD2_k127_1518074_0 PFAM short-chain dehydrogenase reductase SDR K15314 - - 0.0 2005.0
HKD2_k127_1518074_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 3.575e-248 781.0
HKD2_k127_1518074_10 With LivFGHM is involved in the high affinity leucine transport K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005785 392.0
HKD2_k127_1518074_11 PFAM Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002876 380.0
HKD2_k127_1518074_12 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003514 359.0
HKD2_k127_1518074_13 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 357.0
HKD2_k127_1518074_14 sulfate ABC transporter K02046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008787 329.0
HKD2_k127_1518074_15 sulfate ABC transporter K02047 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000042 314.0
HKD2_k127_1518074_16 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000002192 213.0
HKD2_k127_1518074_17 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 - 2.5.1.15,2.7.6.3 0.00000000000000000000000000000000000000000000000000000000007527 216.0
HKD2_k127_1518074_18 Ferredoxin - - - 0.000000000000000000000000000000000000000000000000345 182.0
HKD2_k127_1518074_19 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000002781 192.0
HKD2_k127_1518074_2 Acyl-CoA dehydrogenase, N-terminal domain - - - 7.675e-237 743.0
HKD2_k127_1518074_20 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000002196 184.0
HKD2_k127_1518074_21 of the alpha beta superfamily K06889 - - 0.0000000000000000000000000000000000000000009632 168.0
HKD2_k127_1518074_22 COGs COG3603 conserved K09707 - - 0.000000000000000000000000000000000007249 140.0
HKD2_k127_1518074_23 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000006032 144.0
HKD2_k127_1518074_24 COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA K06169 - - 0.000000000000000000000000000003094 137.0
HKD2_k127_1518074_25 PFAM membrane-bound metal-dependent hydrolase K07038 - - 0.0000000000000000000000000005442 130.0
HKD2_k127_1518074_26 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000001424 119.0
HKD2_k127_1518074_27 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.000000000000000000000000006572 117.0
HKD2_k127_1518074_28 Transcriptional regulator - - - 0.00000000000000000000000002279 113.0
HKD2_k127_1518074_29 - - - - 0.0000000000000000000421 105.0
HKD2_k127_1518074_3 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 2.053e-216 696.0
HKD2_k127_1518074_30 Bacterial membrane protein, YfhO - - - 0.000000002319 71.0
HKD2_k127_1518074_4 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 3.65e-203 653.0
HKD2_k127_1518074_5 Pyridoxal-dependent decarboxylase conserved domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007412 545.0
HKD2_k127_1518074_6 D-alanine [D-alanyl carrier protein] ligase activity K00635 - 2.3.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009731 498.0
HKD2_k127_1518074_7 COG1613 ABC-type sulfate transport system, periplasmic component K02048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009891 451.0
HKD2_k127_1518074_8 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 459.0
HKD2_k127_1518074_9 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006795 405.0
HKD2_k127_1625723_0 Large extracellular alpha-helical protein - - - 0.0 1230.0
HKD2_k127_1625723_1 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 0.0 1043.0
HKD2_k127_1625723_10 Cys/Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004909 402.0
HKD2_k127_1625723_11 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 351.0
HKD2_k127_1625723_12 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009357 372.0
HKD2_k127_1625723_13 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 350.0
HKD2_k127_1625723_14 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 338.0
HKD2_k127_1625723_15 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 329.0
HKD2_k127_1625723_16 ABC-type Zn2 transport system, periplasmic component surface adhesin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 337.0
HKD2_k127_1625723_17 protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003766 308.0
HKD2_k127_1625723_18 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 315.0
HKD2_k127_1625723_19 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002725 281.0
HKD2_k127_1625723_2 4Fe-4S dicluster domain K00184 - - 2.939e-316 997.0
HKD2_k127_1625723_20 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004724 278.0
HKD2_k127_1625723_21 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005818 296.0
HKD2_k127_1625723_22 RNA polymerase recycling family C-terminal K03580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001901 298.0
HKD2_k127_1625723_23 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000001021 279.0
HKD2_k127_1625723_24 Bacterial regulatory proteins, tetR family K16137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003267 257.0
HKD2_k127_1625723_25 Transferrin receptor-like dimerisation domain K01301 - 3.4.17.21 0.000000000000000000000000000000000000000000000000000000000000000000000002518 271.0
HKD2_k127_1625723_26 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000001198 251.0
HKD2_k127_1625723_27 Mannose-6-phosphate isomerase K00971 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000000000000000002504 248.0
HKD2_k127_1625723_28 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000008177 248.0
HKD2_k127_1625723_29 PFAM cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000004099 235.0
HKD2_k127_1625723_3 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 5.926e-258 805.0
HKD2_k127_1625723_30 - - - - 0.000000000000000000000000000000000000000000000000000000000001385 214.0
HKD2_k127_1625723_31 cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000002226 226.0
HKD2_k127_1625723_32 Appr-1'-p processing enzyme - - - 0.0000000000000000000000000000000000000000000000000000000003294 214.0
HKD2_k127_1625723_33 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000008346 214.0
HKD2_k127_1625723_34 Protein of unknown function (DUF3341) - - - 0.000000000000000000000000000000000000000000000000000000002501 223.0
HKD2_k127_1625723_35 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000002953 201.0
HKD2_k127_1625723_36 DinB superfamily - - - 0.000000000000000000000000000000000000000000000003736 180.0
HKD2_k127_1625723_37 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000001526 181.0
HKD2_k127_1625723_38 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000163 158.0
HKD2_k127_1625723_39 Domain of unknown function (DUF3488) - - - 0.00000000000000000000000000000000000008005 165.0
HKD2_k127_1625723_4 Drug exporters of the RND superfamily K06994,K07003,K20466,K20470 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006869,GO:0008150,GO:0009273,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0040007,GO:0042546,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071554,GO:0071702,GO:0071766,GO:0071840,GO:0071944,GO:1901264 - 6.053e-202 652.0
HKD2_k127_1625723_40 metallopeptidase activity K00571,K01126,K01176 - 2.1.1.72,3.1.4.46,3.2.1.1 0.000000000000000000000000000000000004708 158.0
HKD2_k127_1625723_41 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.00000000000000000000000000000000002057 140.0
HKD2_k127_1625723_42 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000003553 138.0
HKD2_k127_1625723_43 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000034 116.0
HKD2_k127_1625723_44 Protein of unknown function DUF58 - - - 0.00000000000000000000000005987 119.0
HKD2_k127_1625723_47 - - - - 0.0000000000000000000007499 103.0
HKD2_k127_1625723_48 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000001488 102.0
HKD2_k127_1625723_49 Ribosomal L32p protein family K02911 - - 0.00000000000000000008562 90.0
HKD2_k127_1625723_5 Tetratricopeptide repeat - - - 1.175e-197 655.0
HKD2_k127_1625723_50 TIGRFAM Caa(3)-type oxidase, subunit IV K02277 - 1.9.3.1 0.0000000000000000001012 93.0
HKD2_k127_1625723_52 Uncharacterized ACR, COG1399 K07040 - - 0.000000000000000000218 102.0
HKD2_k127_1625723_53 polysaccharide deacetylase - - - 0.0000000000001004 85.0
HKD2_k127_1625723_54 ABC transporter - - - 0.000000000002143 79.0
HKD2_k127_1625723_55 - - - - 0.000000001343 66.0
HKD2_k127_1625723_56 serine threonine protein kinase - - - 0.0000333 57.0
HKD2_k127_1625723_57 Yip1 domain - - - 0.00003912 54.0
HKD2_k127_1625723_58 Redoxin - - - 0.0003135 50.0
HKD2_k127_1625723_59 oligosaccharyl transferase activity - - - 0.0006938 54.0
HKD2_k127_1625723_6 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 651.0
HKD2_k127_1625723_60 Sigma-70 region 2 K03088 - - 0.0007687 49.0
HKD2_k127_1625723_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 550.0
HKD2_k127_1625723_8 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006556 482.0
HKD2_k127_1625723_9 Bacterial sugar transferase K03606 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 425.0
HKD2_k127_1688317_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1068.0
HKD2_k127_1688317_1 topoisomerase K02469 - 5.99.1.3 4.854e-274 863.0
HKD2_k127_1688317_10 Magnesium transport protein CorA K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002581 372.0
HKD2_k127_1688317_11 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 363.0
HKD2_k127_1688317_12 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005411 330.0
HKD2_k127_1688317_13 COGs COG0491 Zn-dependent hydrolase including glyoxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 310.0
HKD2_k127_1688317_14 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001525 308.0
HKD2_k127_1688317_15 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009615 250.0
HKD2_k127_1688317_16 Protein of unknown function (DUF2911) - - - 0.000000000000000000000000000000000000000000000000000000000000009482 228.0
HKD2_k127_1688317_17 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000002443 229.0
HKD2_k127_1688317_18 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000003167 226.0
HKD2_k127_1688317_19 COG0424 Nucleotide-binding protein implicated in inhibition of septum formation K06287 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - 0.000000000000000000000000000000000000000000000002308 185.0
HKD2_k127_1688317_2 PFAM BNR Asp-box repeat - - - 2.514e-262 846.0
HKD2_k127_1688317_20 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000004418 159.0
HKD2_k127_1688317_21 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.00000000000000000000000000000000000001211 164.0
HKD2_k127_1688317_22 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000006114 164.0
HKD2_k127_1688317_23 PFAM Phospholipid glycerol acyltransferase K00655 - 2.3.1.51 0.0000000000000000000000000000000001715 141.0
HKD2_k127_1688317_24 ECF sigma factor K03088 - - 0.000000000000000000000000000000003168 138.0
HKD2_k127_1688317_25 DinB family - - - 0.00000000000000000000000000000005967 132.0
HKD2_k127_1688317_26 SnoaL-like domain - - - 0.000000000000000000000000000002102 136.0
HKD2_k127_1688317_27 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000028 115.0
HKD2_k127_1688317_28 outer membrane efflux protein - - - 0.0000000000000000000007182 109.0
HKD2_k127_1688317_29 PFAM Anti-sigma-K factor RskA - - - 0.000000000000000005505 94.0
HKD2_k127_1688317_3 Dehydratase family K01687 - 4.2.1.9 3.009e-234 740.0
HKD2_k127_1688317_30 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000005277 92.0
HKD2_k127_1688317_31 Protein of unknown function (DUF2892) - - - 0.0000000000000007896 93.0
HKD2_k127_1688317_32 (GGDEF) domain - - - 0.000000003142 65.0
HKD2_k127_1688317_33 Putative regulatory protein - - - 0.0000001163 55.0
HKD2_k127_1688317_34 - - - - 0.0000355 51.0
HKD2_k127_1688317_35 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00004286 49.0
HKD2_k127_1688317_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.258e-209 666.0
HKD2_k127_1688317_5 Acetolactate synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 553.0
HKD2_k127_1688317_6 Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family K01486 - 3.5.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002303 526.0
HKD2_k127_1688317_7 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006057 478.0
HKD2_k127_1688317_8 Highly conserved protein containing a thioredoxin domain K06888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 500.0
HKD2_k127_1688317_9 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 433.0
HKD2_k127_1689767_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003125 613.0
HKD2_k127_1689767_1 Cys/Met metabolism PLP-dependent enzyme K01760,K17217 - 4.4.1.1,4.4.1.2,4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 460.0
HKD2_k127_1689767_10 Ami_3 K01448 - 3.5.1.28 0.000000000000000000000000000000000000000000000007539 193.0
HKD2_k127_1689767_11 PHP domain K04477 - - 0.00000000000000000000000000000000000000001432 179.0
HKD2_k127_1689767_12 Flavoprotein K03186 - 2.5.1.129 0.0000000000000000000000000000000000003005 154.0
HKD2_k127_1689767_13 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000188 143.0
HKD2_k127_1689767_14 DoxX K15977 - - 0.00000000000000000000000000000000007145 145.0
HKD2_k127_1689767_15 PFAM Formiminotransferase-cyclodeaminase - - - 0.0000000000000000000000000000000002137 139.0
HKD2_k127_1689767_16 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000001044 127.0
HKD2_k127_1689767_17 Nucleotidyl transferase K00966 - 2.7.7.13 0.00000000000000000000000001269 124.0
HKD2_k127_1689767_18 aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000006706 123.0
HKD2_k127_1689767_19 tRNA (adenine(22)-N(1))-methyltransferase K06967 - 2.1.1.217 0.0000000000000000000001584 106.0
HKD2_k127_1689767_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005431 416.0
HKD2_k127_1689767_20 Putative DNA-binding domain - - - 0.00000000000000000004594 103.0
HKD2_k127_1689767_21 photosystem II stabilization K00703,K02237,K02238 - 2.4.1.21 0.00000000000000000004794 94.0
HKD2_k127_1689767_22 CYTH K05873 - 4.6.1.1 0.0000000000000000001755 104.0
HKD2_k127_1689767_23 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.000000000000000001552 93.0
HKD2_k127_1689767_24 Predicted periplasmic lipoprotein (DUF2279) - - - 0.0000000000000000145 97.0
HKD2_k127_1689767_25 DivIVA protein K04074 - - 0.00000000000002429 79.0
HKD2_k127_1689767_26 AntiSigma factor - - - 0.00000000000008594 83.0
HKD2_k127_1689767_27 C4-type zinc ribbon domain K07164 - - 0.0000000000001494 81.0
HKD2_k127_1689767_28 - - - - 0.000000000002156 72.0
HKD2_k127_1689767_29 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.000000000006176 77.0
HKD2_k127_1689767_3 PFAM FAD dependent oxidoreductase K07137 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 406.0
HKD2_k127_1689767_30 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000001548 61.0
HKD2_k127_1689767_31 (Rhomboid) family - - - 0.00009689 53.0
HKD2_k127_1689767_4 Translation elongation factor K03833 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 401.0
HKD2_k127_1689767_5 Protein of unknown function (DUF692) K09930 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005258 375.0
HKD2_k127_1689767_6 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004401 369.0
HKD2_k127_1689767_7 UbiA prenyltransferase family K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000002874 272.0
HKD2_k127_1689767_8 Deoxynucleoside kinase - - - 0.00000000000000000000000000000000000000000000000000000000000002921 228.0
HKD2_k127_1689767_9 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000001465 189.0
HKD2_k127_1695499_0 B12 binding domain - - - 2.269e-236 767.0
HKD2_k127_1695499_1 Predicted membrane protein (DUF2339) - - - 5.231e-226 739.0
HKD2_k127_1695499_10 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 329.0
HKD2_k127_1695499_11 oligopeptide transport K03305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 309.0
HKD2_k127_1695499_12 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 314.0
HKD2_k127_1695499_13 Hpt domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002207 260.0
HKD2_k127_1695499_14 methyltransferase K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000003759 269.0
HKD2_k127_1695499_15 Methyltransferase small domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000004893 250.0
HKD2_k127_1695499_16 PFAM Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000091 246.0
HKD2_k127_1695499_17 PFAM MOFRL domain protein K11529 - 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000009175 259.0
HKD2_k127_1695499_19 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000007682 205.0
HKD2_k127_1695499_2 transcription factor binding K02584 - - 1.416e-202 644.0
HKD2_k127_1695499_20 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000005837 186.0
HKD2_k127_1695499_21 cell wall anchor domain - - - 0.00000000000000000000000000000004549 147.0
HKD2_k127_1695499_23 FHA domain containing protein - GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - 0.00000000000005207 78.0
HKD2_k127_1695499_24 YXWGXW repeat (2 copies) - - - 0.0000000000003896 73.0
HKD2_k127_1695499_25 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process - - - 0.000000003532 65.0
HKD2_k127_1695499_26 Glycosyl transferase, family 2 - - - 0.000004312 59.0
HKD2_k127_1695499_3 B12 binding domain K04034 - 1.21.98.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001935 606.0
HKD2_k127_1695499_4 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006549 566.0
HKD2_k127_1695499_5 radical SAM domain protein K04034 - 1.21.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003344 562.0
HKD2_k127_1695499_6 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 469.0
HKD2_k127_1695499_7 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000355 472.0
HKD2_k127_1695499_8 Sensor protein, DUF3365, HAMP and PAS domain-containing, heme-binding K05962 - 2.7.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 343.0
HKD2_k127_1695499_9 Zinc carboxypeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 317.0
HKD2_k127_1724104_0 PFAM peptidase S9A prolyl oligopeptidase domain protein beta-propeller K01354 - 3.4.21.83 1.229e-242 770.0
HKD2_k127_1724104_1 cellulose binding - - - 9.799e-242 777.0
HKD2_k127_1724104_10 PFAM NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006178 389.0
HKD2_k127_1724104_11 unsaturated fatty acid biosynthetic process K04712 - 1.14.18.5,1.14.19.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 390.0
HKD2_k127_1724104_12 Zinc-binding alcohol dehydrogenase family protein K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004515 376.0
HKD2_k127_1724104_13 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 306.0
HKD2_k127_1724104_14 Mut7-C ubiquitin K09122 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 285.0
HKD2_k127_1724104_15 - - - - 0.000000000000000000000000000000000000000000000000000000001348 207.0
HKD2_k127_1724104_16 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000001119 205.0
HKD2_k127_1724104_17 RmlD substrate binding domain K00067 - 1.1.1.133 0.00000000000000000000000000000000000000000000000001597 194.0
HKD2_k127_1724104_18 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000000278 187.0
HKD2_k127_1724104_19 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000000000000000000000005219 190.0
HKD2_k127_1724104_2 beta-lactamase - - - 2.374e-234 749.0
HKD2_k127_1724104_20 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000000002507 146.0
HKD2_k127_1724104_21 DinB family - - - 0.0000000000000000000000000000000002465 148.0
HKD2_k127_1724104_22 - - - - 0.0000000000000000000000001914 115.0
HKD2_k127_1724104_23 - - - - 0.00000000000000000000004062 107.0
HKD2_k127_1724104_24 PQ loop repeat K15383 - - 0.0000000000000000000001753 99.0
HKD2_k127_1724104_25 TIGRFAM MJ0042 family finger-like protein - - - 0.00000000000000000005278 100.0
HKD2_k127_1724104_26 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.000000000000000002277 98.0
HKD2_k127_1724104_27 CAAX protease self-immunity K07052 - - 0.000000000001777 77.0
HKD2_k127_1724104_29 Belongs to the peptidase S8 family K20276 - - 0.00000001296 67.0
HKD2_k127_1724104_3 PFAM GlcNAc-PI de-N-acetylase - - - 5.812e-229 736.0
HKD2_k127_1724104_30 Protein of unknown function (DUF2752) - - - 0.0000001776 59.0
HKD2_k127_1724104_31 PFAM regulatory protein, MarR - - - 0.00001436 49.0
HKD2_k127_1724104_4 oxidoreductase activity - - - 3.697e-219 685.0
HKD2_k127_1724104_5 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004266 611.0
HKD2_k127_1724104_6 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 622.0
HKD2_k127_1724104_7 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000301 486.0
HKD2_k127_1724104_8 metal-dependent hydrolase with the TIM-barrel fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002871 484.0
HKD2_k127_1724104_9 Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002603 477.0
HKD2_k127_1733375_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000723 305.0
HKD2_k127_1733375_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.000000000000000000000000002423 118.0
HKD2_k127_17483_0 COG NOG10142 non supervised orthologous group - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 481.0
HKD2_k127_17483_1 PFAM amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 464.0
HKD2_k127_17483_2 Belongs to the glutaminase family K01425 - 3.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 446.0
HKD2_k127_17483_3 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 423.0
HKD2_k127_17483_4 Fumarase C C-terminus K01744 - 4.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 395.0
HKD2_k127_17483_5 cheY-homologous receiver domain - - - 0.000000000000000000000000001309 120.0
HKD2_k127_17483_6 helix_turn_helix, Lux Regulon - - - 0.000000000000718 69.0
HKD2_k127_17483_7 Protein of unknown function (DUF3011) - - - 0.00000000005534 76.0
HKD2_k127_17483_8 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.000003966 59.0
HKD2_k127_1827347_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895,K01907,K01908 - 6.2.1.1,6.2.1.16,6.2.1.17 0.0 1071.0
HKD2_k127_1827347_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001844 514.0
HKD2_k127_1827347_10 Belongs to the HAM1 NTPase family K02428 - 3.6.1.66 0.000000000000000000000000000004041 138.0
HKD2_k127_1827347_11 Lytic transglycolase K03642 - - 0.00000000000000000000000000002176 136.0
HKD2_k127_1827347_12 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000000000004067 77.0
HKD2_k127_1827347_13 Aminotransferase - - - 0.0001477 46.0
HKD2_k127_1827347_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003609 427.0
HKD2_k127_1827347_3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007958 373.0
HKD2_k127_1827347_4 Amidinotransferase K01478 - 3.5.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 332.0
HKD2_k127_1827347_5 Amino acid kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004626 346.0
HKD2_k127_1827347_6 Major Facilitator Superfamily K08223 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007781 326.0
HKD2_k127_1827347_7 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003737 301.0
HKD2_k127_1827347_8 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000008737 269.0
HKD2_k127_1827347_9 methyltransferase activity - - - 0.00000000000000000000000000000000000000000000004266 187.0
HKD2_k127_2040950_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.056e-200 631.0
HKD2_k127_2040950_1 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002324 559.0
HKD2_k127_2040950_2 PFAM Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 314.0
HKD2_k127_2040950_3 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000003904 224.0
HKD2_k127_2040950_4 Polymer-forming cytoskeletal - - - 0.000000000000000000001178 108.0
HKD2_k127_2040950_5 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000000000008021 90.0
HKD2_k127_2040950_6 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0000000000000001869 85.0
HKD2_k127_2040950_7 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000004323 87.0
HKD2_k127_2040950_8 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 0.00000000000004471 86.0
HKD2_k127_2082094_0 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 612.0
HKD2_k127_2082094_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004509 504.0
HKD2_k127_2082094_10 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.0000000000000000000000000000000000000004788 169.0
HKD2_k127_2082094_11 Membrane - - - 0.0000000000000000000000000000000000002074 162.0
HKD2_k127_2082094_12 Protein of unknown function, DUF547 - - - 0.0000000000000000000000000000000000005472 149.0
HKD2_k127_2082094_13 Belongs to the ompA family - - - 0.00000000000000000000000000000000007924 148.0
HKD2_k127_2082094_14 Phosphoglycerate mutase family - - - 0.000000000000000000000000000000004132 136.0
HKD2_k127_2082094_15 Protein of unknown function (DUF1634) - - - 0.000000000000000000000000007842 113.0
HKD2_k127_2082094_16 von Willebrand factor, type A - - - 0.00000000000000000001476 104.0
HKD2_k127_2082094_17 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 0.000000002863 61.0
HKD2_k127_2082094_18 polysaccharide deacetylase - - - 0.00000001173 68.0
HKD2_k127_2082094_2 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005793 422.0
HKD2_k127_2082094_3 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008025 387.0
HKD2_k127_2082094_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 404.0
HKD2_k127_2082094_5 acid phosphatase activity K01077 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005458 367.0
HKD2_k127_2082094_6 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005183 342.0
HKD2_k127_2082094_7 Protein of unknown function (DUF1684) K09164 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001065 275.0
HKD2_k127_2082094_8 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000007913 215.0
HKD2_k127_2082094_9 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000005781 173.0
HKD2_k127_2093039_0 Prolyl oligopeptidase K01322 - 3.4.21.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 509.0
HKD2_k127_2093039_1 Belongs to the 5'-nucleotidase family K01081 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 469.0
HKD2_k127_2219767_0 Sortilin, neurotensin receptor 3, - - - 0.0 1179.0
HKD2_k127_2219767_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 1.633e-210 684.0
HKD2_k127_2219767_10 Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family K03317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009868 379.0
HKD2_k127_2219767_11 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K00772,K03783 - 2.4.2.1,2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 304.0
HKD2_k127_2219767_12 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000902 310.0
HKD2_k127_2219767_13 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001077 276.0
HKD2_k127_2219767_14 Cytidine and deoxycytidylate deaminase zinc-binding region K01489 - 3.5.4.5 0.0000000000000000000000000000000003435 147.0
HKD2_k127_2219767_15 Transcriptional regulatory protein, C terminal - - - 0.0000000000000001739 89.0
HKD2_k127_2219767_16 histone H2A K63-linked ubiquitination K08884,K11894 - 2.7.11.1 0.00000003876 63.0
HKD2_k127_2219767_2 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 2.953e-205 652.0
HKD2_k127_2219767_3 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006778 626.0
HKD2_k127_2219767_4 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 625.0
HKD2_k127_2219767_5 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009627 600.0
HKD2_k127_2219767_6 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002802 566.0
HKD2_k127_2219767_7 Bacterial protein of unknown function (DUF885) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004048 501.0
HKD2_k127_2219767_8 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003861 404.0
HKD2_k127_2219767_9 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00756,K00758 - 2.4.2.2,2.4.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002926 392.0
HKD2_k127_2230607_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 9.48e-197 626.0
HKD2_k127_2230607_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 483.0
HKD2_k127_2230607_10 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000000000003116 174.0
HKD2_k127_2230607_11 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000008538 89.0
HKD2_k127_2230607_12 TIGRFAM VWFA-related Acidobacterial domain - - - 0.0000000000002302 83.0
HKD2_k127_2230607_13 - - - - 0.00000000001747 77.0
HKD2_k127_2230607_14 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000002241 62.0
HKD2_k127_2230607_15 Domain of unknown function (DUF4388) - - - 0.0000003866 63.0
HKD2_k127_2230607_16 Tetratricopeptide repeat - - - 0.0000008346 62.0
HKD2_k127_2230607_17 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000005767 57.0
HKD2_k127_2230607_18 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00003354 53.0
HKD2_k127_2230607_19 Acetyltransferase (GNAT) domain - - - 0.000351 51.0
HKD2_k127_2230607_2 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004066 440.0
HKD2_k127_2230607_3 5'-nucleotidase, C-terminal domain K01119 - 3.1.3.6,3.1.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 442.0
HKD2_k127_2230607_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003412 361.0
HKD2_k127_2230607_5 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006118 287.0
HKD2_k127_2230607_6 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000004456 259.0
HKD2_k127_2230607_7 PFAM Thymidine kinase K00857 - 2.7.1.21 0.000000000000000000000000000000000000000000000000000000000000000003146 244.0
HKD2_k127_2230607_8 TonB-dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000001159 236.0
HKD2_k127_2230607_9 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000212 172.0
HKD2_k127_2433618_0 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000008683 239.0
HKD2_k127_2433618_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000017 237.0
HKD2_k127_2433618_2 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000000000000000000000000000000007101 201.0
HKD2_k127_25182_0 PFAM peptidase K01284,K01414 - 3.4.15.5,3.4.24.70 1.165e-262 830.0
HKD2_k127_25182_1 Major Facilitator Superfamily - - - 3.362e-205 646.0
HKD2_k127_25182_10 periplasmic solute binding protein K02077 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 391.0
HKD2_k127_25182_11 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 379.0
HKD2_k127_25182_12 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 - 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000847 349.0
HKD2_k127_25182_13 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 322.0
HKD2_k127_25182_14 Intracellular protease, PfpI family K05520 - 3.5.1.124 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004414 315.0
HKD2_k127_25182_15 TIGRFAM competence damage-inducible protein CinA K03742,K03743 - 3.5.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000399 315.0
HKD2_k127_25182_16 Phosphate transport system permease protein PstA K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 302.0
HKD2_k127_25182_17 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000518 299.0
HKD2_k127_25182_18 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003005 296.0
HKD2_k127_25182_19 pfam abc-3 K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001343 291.0
HKD2_k127_25182_2 Peptidase dimerisation domain - - - 6.082e-205 649.0
HKD2_k127_25182_20 lipoprotein localization to outer membrane K02004,K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000004502 273.0
HKD2_k127_25182_21 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000001251 236.0
HKD2_k127_25182_22 histidine kinase HAMP region domain protein K07636 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000004658 248.0
HKD2_k127_25182_23 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000007024 242.0
HKD2_k127_25182_24 PFAM response regulator receiver K02483,K07658,K07668 - - 0.00000000000000000000000000000000000000000000000000000000000163 230.0
HKD2_k127_25182_25 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000000000766 198.0
HKD2_k127_25182_26 Belongs to the bacterial solute-binding protein 9 family K09815 - - 0.0000000000000000000000000000000000000000000000000002901 198.0
HKD2_k127_25182_27 Plays a role in the regulation of phosphate uptake K02039 - - 0.00000000000000000000000000000000000000000000000001039 206.0
HKD2_k127_25182_28 (ABC) transporter - - - 0.00000000000000000000000000000000000000000000000002466 197.0
HKD2_k127_25182_29 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate - - - 0.000000000000000000000000000000000000000000002536 174.0
HKD2_k127_25182_3 Prolyl oligopeptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008792 583.0
HKD2_k127_25182_30 Psort location Cytoplasmic, score 8.96 - - - 0.00000000000000000000000000000000000000002833 154.0
HKD2_k127_25182_31 PFAM ABC-3 protein K09816,K09819,K19976 - - 0.00000000000000000000000000000000000000003274 170.0
HKD2_k127_25182_32 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.00000000000000000000000000000000002275 154.0
HKD2_k127_25182_33 ABC transporter K09817 - - 0.000000000000000000000000000007899 127.0
HKD2_k127_25182_34 (twin-arginine translocation) pathway signal - - - 0.00000000000000000000000000001527 134.0
HKD2_k127_25182_35 - - - - 0.000000000000000000227 89.0
HKD2_k127_25182_36 polysaccharide deacetylase - - - 0.000000000000008732 88.0
HKD2_k127_25182_37 Outer membrane lipoprotein-sorting protein - - - 0.0000000000101 79.0
HKD2_k127_25182_39 - - - - 0.000004726 55.0
HKD2_k127_25182_4 phosphate-selective porin O and P - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 457.0
HKD2_k127_25182_40 - - - - 0.00001326 55.0
HKD2_k127_25182_5 esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 443.0
HKD2_k127_25182_6 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 445.0
HKD2_k127_25182_7 Belongs to the PstS family K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003 410.0
HKD2_k127_25182_8 Phosphate transporter family K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 419.0
HKD2_k127_25182_9 Tetratricopeptide repeats K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005789 423.0
HKD2_k127_2565248_0 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 316.0
HKD2_k127_2565248_1 PFAM glycosyl transferase group 1 - - - 0.0000000000000000000000000000000000000000000000000000000001769 211.0
HKD2_k127_2618187_0 Asparaginyl-tRNA synthetase K01893 GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005455 561.0
HKD2_k127_2618187_1 Acyl-CoA dehydrogenase, C-terminal domain K00252 - 1.3.8.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002343 524.0
HKD2_k127_2618187_10 Belongs to the ribF family K11753 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 0.00000000000000000000000000000000000000000000000000000000000000000001808 243.0
HKD2_k127_2618187_11 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000005122 243.0
HKD2_k127_2618187_12 protein phosphatase 2C domain protein K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000001197 232.0
HKD2_k127_2618187_13 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000005123 232.0
HKD2_k127_2618187_14 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658,K01664 - 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000002424 239.0
HKD2_k127_2618187_15 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000001106 233.0
HKD2_k127_2618187_16 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000001443 225.0
HKD2_k127_2618187_17 imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.0000000000000000000000000000000000000000000000000002552 202.0
HKD2_k127_2618187_18 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000723 199.0
HKD2_k127_2618187_19 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000009361 178.0
HKD2_k127_2618187_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0003824,GO:0004834,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 507.0
HKD2_k127_2618187_20 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000004661 183.0
HKD2_k127_2618187_21 Heat shock protein DnaJ domain protein - - - 0.0000000000000000000000000000000000000000006594 174.0
HKD2_k127_2618187_22 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000001233 164.0
HKD2_k127_2618187_23 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.00000000000000000000000000000000000001912 156.0
HKD2_k127_2618187_24 TIGRFAM diguanylate cyclase - - - 0.000000000000000000000000000000000002136 154.0
HKD2_k127_2618187_25 - - - - 0.00000000000000000000000000000000003795 154.0
HKD2_k127_2618187_26 Helix-turn-helix domain - - - 0.0000000000000005467 88.0
HKD2_k127_2618187_27 molecular chaperone K03686 - - 0.0000000001076 70.0
HKD2_k127_2618187_28 - - - - 0.0000000003345 71.0
HKD2_k127_2618187_29 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000865 62.0
HKD2_k127_2618187_3 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 418.0
HKD2_k127_2618187_4 amidase activity K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009174 417.0
HKD2_k127_2618187_5 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 410.0
HKD2_k127_2618187_6 ATP-dependent helicase activity K10844 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 417.0
HKD2_k127_2618187_7 Polysaccharide biosynthesis protein K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004682 311.0
HKD2_k127_2618187_8 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001579 289.0
HKD2_k127_2618187_9 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K01663,K02500 GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003939 291.0
HKD2_k127_2628399_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1864.0
HKD2_k127_2628399_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 4.138e-301 940.0
HKD2_k127_2628399_10 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 609.0
HKD2_k127_2628399_11 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043,K13797 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004923 564.0
HKD2_k127_2628399_12 Transglycosylase K05365,K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006624 529.0
HKD2_k127_2628399_13 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 507.0
HKD2_k127_2628399_14 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 439.0
HKD2_k127_2628399_15 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 436.0
HKD2_k127_2628399_16 ADP-glyceromanno-heptose 6-epimerase activity K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 410.0
HKD2_k127_2628399_17 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004274 393.0
HKD2_k127_2628399_18 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 389.0
HKD2_k127_2628399_19 PFAM glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008323 416.0
HKD2_k127_2628399_2 PFAM Prolyl oligopeptidase family - - - 1.758e-244 771.0
HKD2_k127_2628399_20 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 331.0
HKD2_k127_2628399_21 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 329.0
HKD2_k127_2628399_22 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001572 321.0
HKD2_k127_2628399_23 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 289.0
HKD2_k127_2628399_24 imidazolonepropionase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000684 299.0
HKD2_k127_2628399_25 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009878 277.0
HKD2_k127_2628399_26 Metallopeptidase family M24 K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000006594 269.0
HKD2_k127_2628399_27 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008784 254.0
HKD2_k127_2628399_28 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001145 259.0
HKD2_k127_2628399_29 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006147 265.0
HKD2_k127_2628399_3 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 2.569e-219 707.0
HKD2_k127_2628399_30 Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004547 264.0
HKD2_k127_2628399_31 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000001111 241.0
HKD2_k127_2628399_32 Squalene/phytoene synthase K00801 - 2.5.1.21 0.00000000000000000000000000000000000000000000000000000000000000001551 245.0
HKD2_k127_2628399_33 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000000000000000000000000000000000000000000000000000000004017 224.0
HKD2_k127_2628399_34 4Fe-4S single cluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000005661 225.0
HKD2_k127_2628399_35 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K03660 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000007162 224.0
HKD2_k127_2628399_36 DHH family K06881 - 3.1.13.3,3.1.3.7 0.0000000000000000000000000000000000000000000000000000000000001089 230.0
HKD2_k127_2628399_37 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000002489 208.0
HKD2_k127_2628399_38 Ribosomal protein S5, C-terminal domain K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000003538 214.0
HKD2_k127_2628399_39 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000001056 225.0
HKD2_k127_2628399_4 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 6.297e-214 690.0
HKD2_k127_2628399_40 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) K03802,K05844 - 6.3.2.29,6.3.2.30 0.0000000000000000000000000000000000000000000000000000000214 222.0
HKD2_k127_2628399_41 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000001263 195.0
HKD2_k127_2628399_42 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon K00966,K05305,K16881 - 2.7.1.52,2.7.7.13,5.4.2.8 0.00000000000000000000000000000000000000000000000000001296 204.0
HKD2_k127_2628399_43 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000002564 190.0
HKD2_k127_2628399_44 lysyltransferase activity K07027 - - 0.0000000000000000000000000000000000000000000000000003576 205.0
HKD2_k127_2628399_45 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000001334 182.0
HKD2_k127_2628399_46 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000004775 184.0
HKD2_k127_2628399_47 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.0000000000000000000000000000000000000000000001066 172.0
HKD2_k127_2628399_48 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000000000000008135 169.0
HKD2_k127_2628399_49 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000001028 161.0
HKD2_k127_2628399_5 imidazolonepropionase activity K01443 - 3.5.1.25 4.939e-210 702.0
HKD2_k127_2628399_50 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01560,K07025,K20862 - 3.1.3.102,3.1.3.104,3.8.1.2 0.0000000000000000000000000000000000000000005904 178.0
HKD2_k127_2628399_51 structural constituent of ribosome K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000001622 164.0
HKD2_k127_2628399_52 Chalcone isomerase-like - - - 0.000000000000000000000000000000000000000009108 177.0
HKD2_k127_2628399_53 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.0000000000000000000000000000000000000000371 154.0
HKD2_k127_2628399_54 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.000000000000000000000000000000000000001231 165.0
HKD2_k127_2628399_55 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000007987 161.0
HKD2_k127_2628399_56 Binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000008499 155.0
HKD2_k127_2628399_57 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000006944 142.0
HKD2_k127_2628399_58 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000001005 138.0
HKD2_k127_2628399_59 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000004637 125.0
HKD2_k127_2628399_6 PFAM Prenyltransferase squalene oxidase K06045 - 4.2.1.129,5.4.99.17 1.438e-207 665.0
HKD2_k127_2628399_60 Transcription elongation factor, N-terminal - - - 0.0000000000000000000000000000005212 141.0
HKD2_k127_2628399_61 Ribosomal_S15 K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000001086 123.0
HKD2_k127_2628399_62 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000007717 116.0
HKD2_k127_2628399_63 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000000009825 111.0
HKD2_k127_2628399_64 FAD linked oxidase domain protein K00103,K16653 GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010383,GO:0016020,GO:0016051,GO:0031221,GO:0033692,GO:0034637,GO:0034645,GO:0035884,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0070589,GO:0070592,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901576 1.1.3.8,1.1.98.3 0.000000000000000000000004476 116.0
HKD2_k127_2628399_65 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000571 106.0
HKD2_k127_2628399_66 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.000000000000000000005543 93.0
HKD2_k127_2628399_67 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000009381 92.0
HKD2_k127_2628399_68 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.000000000000001756 87.0
HKD2_k127_2628399_69 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) K02907 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000004266 70.0
HKD2_k127_2628399_7 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 4.192e-203 683.0
HKD2_k127_2628399_70 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000001885 80.0
HKD2_k127_2628399_71 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000002566 67.0
HKD2_k127_2628399_72 TonB C terminal - - - 0.0000000003494 73.0
HKD2_k127_2628399_73 Protein of unknown function (DUF503) K09764 - - 0.0000000005243 66.0
HKD2_k127_2628399_74 Belongs to the universal ribosomal protein uL29 family K02904 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000002821 61.0
HKD2_k127_2628399_75 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0000002794 62.0
HKD2_k127_2628399_76 O-linked GlcNAc transferase-putative TPR-containing transmembrane protein - - - 0.0000003096 64.0
HKD2_k127_2628399_8 Elongation factor Tu C-terminal domain K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000763 614.0
HKD2_k127_2628399_9 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 599.0
HKD2_k127_2665185_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001213 278.0
HKD2_k127_2665185_1 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000003585 221.0
HKD2_k127_2665185_2 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.000000000000000000001124 104.0
HKD2_k127_2665185_3 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0000000151 62.0
HKD2_k127_2665185_4 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.0001788 53.0
HKD2_k127_2677894_0 Glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 2351.0
HKD2_k127_2677894_1 glucose sorbosone K00117 - 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 422.0
HKD2_k127_2677894_2 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 419.0
HKD2_k127_2677894_3 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003472 345.0
HKD2_k127_2677894_4 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009517 331.0
HKD2_k127_2677894_5 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002364 269.0
HKD2_k127_2677894_6 STAS domain K04749 - - 0.000959 47.0
HKD2_k127_2731154_0 PFAM natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001387 525.0
HKD2_k127_2731154_1 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002189 290.0
HKD2_k127_2731154_2 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000005271 151.0
HKD2_k127_2731154_3 PFAM Uncharacterised protein family UPF0079, ATPase K06925 - - 0.00000000000000000000003431 104.0
HKD2_k127_2731154_4 protein conserved in bacteria (DUF2064) K09931 - - 0.00000000000000000000009 108.0
HKD2_k127_2731154_5 oxidoreductase activity - - - 0.0000003065 63.0
HKD2_k127_2779895_0 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000000000000000000000000001606 143.0
HKD2_k127_2779895_1 Pkd domain containing protein - - - 0.00000000000005067 86.0
HKD2_k127_2779895_2 ubiE/COQ5 methyltransferase family - - - 0.00000000001651 66.0
HKD2_k127_2779895_3 PFAM Methyltransferase type 11 K05928,K18897 - 2.1.1.157,2.1.1.95 0.0000000002462 72.0
HKD2_k127_2779895_4 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000009997 68.0
HKD2_k127_2801018_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.786e-281 893.0
HKD2_k127_2801018_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 5.79e-237 744.0
HKD2_k127_2801018_10 Belongs to the KdsA family K01627 - 2.5.1.55 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008997 306.0
HKD2_k127_2801018_11 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003127 285.0
HKD2_k127_2801018_12 Belongs to the 5'-nucleotidase family K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006553 293.0
HKD2_k127_2801018_13 Activator of Hsp90 ATPase 1 family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001205 270.0
HKD2_k127_2801018_14 PFAM Histone deacetylase domain K04768 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003172 267.0
HKD2_k127_2801018_15 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003976 242.0
HKD2_k127_2801018_16 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004937 256.0
HKD2_k127_2801018_17 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000001688 239.0
HKD2_k127_2801018_18 Belongs to the UPF0234 family K09767 - - 0.00000000000000000000000000000000000000000000000000005177 194.0
HKD2_k127_2801018_19 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000009674 205.0
HKD2_k127_2801018_2 Belongs to the citrate synthase family K01647 - 2.3.3.1 4.838e-215 675.0
HKD2_k127_2801018_20 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - 0.0000000000000000000000000000000000000000000000006816 179.0
HKD2_k127_2801018_21 glycerophosphodiester phosphodiesterase activity K01126 - 3.1.4.46 0.00000000000000000000000000000000000000000000002042 179.0
HKD2_k127_2801018_22 gluconolactonase activity K01448,K02395,K08651 - 3.4.21.66,3.5.1.28 0.000000000000000000000000000000000000002424 166.0
HKD2_k127_2801018_23 Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate K03270 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008781,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070567,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 3.1.3.45 0.0000000000000000000000000000000003199 139.0
HKD2_k127_2801018_24 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000002174 117.0
HKD2_k127_2801018_25 - - - - 0.000000000000000000003674 99.0
HKD2_k127_2801018_26 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000121 102.0
HKD2_k127_2801018_27 WYL domain K13572 - - 0.0000000000000000007383 100.0
HKD2_k127_2801018_28 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000000000008198 87.0
HKD2_k127_2801018_29 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117,K03646 - - 0.00000000000008267 75.0
HKD2_k127_2801018_3 ATP-dependent peptidase activity K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004557 563.0
HKD2_k127_2801018_30 Type II secretion system (T2SS), protein G K02456 - - 0.000000006317 64.0
HKD2_k127_2801018_31 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000002374 58.0
HKD2_k127_2801018_32 outer membrane lipoprotein carrier protein LolA K03634 - - 0.00001499 58.0
HKD2_k127_2801018_33 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.00007672 54.0
HKD2_k127_2801018_4 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005581 487.0
HKD2_k127_2801018_5 Threonyl and Alanyl tRNA synthetase second additional domain K01872 - 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 437.0
HKD2_k127_2801018_6 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000635 421.0
HKD2_k127_2801018_7 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002956 383.0
HKD2_k127_2801018_8 Inner membrane component of T3SS, cytoplasmic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 391.0
HKD2_k127_2801018_9 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 348.0
HKD2_k127_2807053_0 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000000000000000000009041 131.0
HKD2_k127_2807053_1 Methionine synthase II (cobalamin-independent) K00549 - 2.1.1.14 0.00000000000000000000000000009575 116.0
HKD2_k127_2807053_2 TIGRFAM conserved repeat domain - - - 0.000000000000000000000000001026 120.0
HKD2_k127_2856266_0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006749 349.0
HKD2_k127_2856266_1 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 339.0
HKD2_k127_2856266_10 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000003692 182.0
HKD2_k127_2856266_11 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000004557 162.0
HKD2_k127_2856266_12 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.0000000000000000000000000000000000000001854 156.0
HKD2_k127_2856266_13 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0004140,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032552,GO:0032553,GO:0032554,GO:0032557,GO:0032558,GO:0032564,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.0000000000000000000000000000000000004387 148.0
HKD2_k127_2856266_14 non-canonical purine NTP pyrophosphatase, RdgB HAM1 family K02428 - 3.6.1.66 0.00000000000000000000000000000000004992 151.0
HKD2_k127_2856266_15 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.0000000000000000000000000000000009929 139.0
HKD2_k127_2856266_16 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000001451 98.0
HKD2_k127_2856266_17 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.000000000000002081 78.0
HKD2_k127_2856266_18 - - - - 0.00000001343 60.0
HKD2_k127_2856266_19 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.0000001625 56.0
HKD2_k127_2856266_2 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006883 318.0
HKD2_k127_2856266_21 - - - - 0.00008661 49.0
HKD2_k127_2856266_3 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 308.0
HKD2_k127_2856266_4 PFAM Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000001459 237.0
HKD2_k127_2856266_5 Participates in transcription elongation, termination and antitermination K02601 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000000002276 229.0
HKD2_k127_2856266_6 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - 0.00000000000000000000000000000000000000000000000000000000000003135 225.0
HKD2_k127_2856266_7 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000009649 212.0
HKD2_k127_2856266_8 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000001128 195.0
HKD2_k127_2856266_9 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000002548 182.0
HKD2_k127_2859270_0 COG1668 ABC-type Na efflux pump, permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005907 252.0
HKD2_k127_2859270_1 PFAM Glycosyl transferase, group 1 K13668 GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.346 0.0000000000000000000000000000000000000003475 162.0
HKD2_k127_2862169_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 3.241e-210 660.0
HKD2_k127_2862169_1 malic enzyme K00027,K00029,K00625,K13788 GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 6.383e-197 656.0
HKD2_k127_2862169_10 peptidase S9B dipeptidylpeptidase IV domain protein K01278 - 3.4.14.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 487.0
HKD2_k127_2862169_11 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 449.0
HKD2_k127_2862169_12 two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002815 423.0
HKD2_k127_2862169_13 Evidence 4 Homologs of previously reported genes of - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003591 412.0
HKD2_k127_2862169_14 FAD linked oxidases, C-terminal domain K00104,K18930 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005615 405.0
HKD2_k127_2862169_15 ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 356.0
HKD2_k127_2862169_16 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007732 348.0
HKD2_k127_2862169_17 PFAM Formiminotransferase K00603 - 2.1.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 344.0
HKD2_k127_2862169_18 polysaccharide catabolic process K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 351.0
HKD2_k127_2862169_19 competence protein COMEC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005599 348.0
HKD2_k127_2862169_2 peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007888 619.0
HKD2_k127_2862169_20 Carboxyl transferase domain K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009581 336.0
HKD2_k127_2862169_21 PFAM Peptidase M16 inactive domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006704 339.0
HKD2_k127_2862169_22 protein kinase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 340.0
HKD2_k127_2862169_23 histidine kinase HAMP region domain protein K13598 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008409 331.0
HKD2_k127_2862169_24 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 291.0
HKD2_k127_2862169_25 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007159 287.0
HKD2_k127_2862169_26 T4-like virus tail tube protein gp19 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001504 276.0
HKD2_k127_2862169_27 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000008091 279.0
HKD2_k127_2862169_28 PFAM Peptidase M16 inactive domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007142 282.0
HKD2_k127_2862169_29 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002409 246.0
HKD2_k127_2862169_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 564.0
HKD2_k127_2862169_30 Belongs to the dGTPase family. Type 2 subfamily K01129 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000008544 265.0
HKD2_k127_2862169_31 PFAM Glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.000000000000000000000000000000000000000000000000000000000000000011 228.0
HKD2_k127_2862169_32 ABC transporter K09812 - - 0.00000000000000000000000000000000000000000000000000000000000000005355 248.0
HKD2_k127_2862169_33 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.0000000000000000000000000000000000000000000000000000000000000002469 231.0
HKD2_k127_2862169_34 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000006039 220.0
HKD2_k127_2862169_35 FecCD transport family K02015 - - 0.00000000000000000000000000000000000000000000000000000000000001103 238.0
HKD2_k127_2862169_36 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000283 239.0
HKD2_k127_2862169_37 MiaB-like tRNA modifying enzyme K18707 - 2.8.4.5 0.0000000000000000000000000000000000000000000000000000000000006974 242.0
HKD2_k127_2862169_38 esterase - - - 0.000000000000000000000000000000000000000000000000000000008189 225.0
HKD2_k127_2862169_39 Kdo2-lipid A biosynthetic process K02517,K22311 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016746,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.3.1.241,2.3.1.265 0.00000000000000000000000000000000000000000000000000000002894 209.0
HKD2_k127_2862169_4 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001209 537.0
HKD2_k127_2862169_40 NAD-dependent epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000001024 207.0
HKD2_k127_2862169_41 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000001761 199.0
HKD2_k127_2862169_42 DinB superfamily - - - 0.000000000000000000000000000000000000000000000000001123 189.0
HKD2_k127_2862169_43 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000001561 184.0
HKD2_k127_2862169_44 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020,K00042,K18121 - 1.1.1.31,1.1.1.60,1.1.1.79 0.0000000000000000000000000000000000000000000000002291 187.0
HKD2_k127_2862169_45 PFAM ABC transporter related K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000004186 197.0
HKD2_k127_2862169_46 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000006146 197.0
HKD2_k127_2862169_47 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000001943 183.0
HKD2_k127_2862169_48 COG0698 Ribose 5-phosphate isomerase RpiB K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000002002 168.0
HKD2_k127_2862169_49 PAP2 superfamily C-terminal - - - 0.00000000000000000000000000000000000000000000207 172.0
HKD2_k127_2862169_5 PFAM Pyridoxal-dependent decarboxylase K01580 - 4.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 492.0
HKD2_k127_2862169_50 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.000000000000000000000000000000000000000000005395 167.0
HKD2_k127_2862169_51 HD domain - - - 0.0000000000000000000000000000000000000000001785 180.0
HKD2_k127_2862169_52 Protein of unknown function (DUF664) - - - 0.0000000000000000000000000000000000000000001795 175.0
HKD2_k127_2862169_53 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.000000000000000000000000000000000000000001108 180.0
HKD2_k127_2862169_54 PFAM glutamine amidotransferase class-I K07010 - - 0.0000000000000000000000000000000000006534 157.0
HKD2_k127_2862169_55 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000006982 157.0
HKD2_k127_2862169_56 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.00000000000000000000000000000000008556 147.0
HKD2_k127_2862169_57 - - - - 0.0000000000000000000000000000000006659 145.0
HKD2_k127_2862169_58 AI-2E family transporter - - - 0.0000000000000000000000000000000009882 144.0
HKD2_k127_2862169_59 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K01760 - 4.4.1.8 0.000000000000000000000000000000004606 138.0
HKD2_k127_2862169_6 GatB domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006784 488.0
HKD2_k127_2862169_60 protein involved in formation of curli polymers - - - 0.00000000000000000000000000000001001 141.0
HKD2_k127_2862169_61 Belongs to the Fur family K09825 - - 0.0000000000000000000000000000002315 127.0
HKD2_k127_2862169_62 methylamine metabolic process - - - 0.0000000000000000000000000000008469 141.0
HKD2_k127_2862169_63 Glycosyl transferase family 2 - - - 0.00000000000000000000000000004566 136.0
HKD2_k127_2862169_64 serine-type endopeptidase activity K20276 - - 0.0000000000000000000000000001461 134.0
HKD2_k127_2862169_65 protein kinase activity - - - 0.00000000000000000000000001289 127.0
HKD2_k127_2862169_66 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.00000000000000000000000003006 119.0
HKD2_k127_2862169_67 Smr domain - - - 0.000000000000000000000000271 108.0
HKD2_k127_2862169_68 phosphorelay signal transduction system - - - 0.000000000000000000000001179 117.0
HKD2_k127_2862169_69 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000009167 111.0
HKD2_k127_2862169_7 fructose-bisphosphate aldolase activity K01624 - 4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007364 487.0
HKD2_k127_2862169_70 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.000000000000000000007788 107.0
HKD2_k127_2862169_71 Acetyltransferase (GNAT) domain - - - 0.000000000000003993 88.0
HKD2_k127_2862169_72 PhoD-like phosphatase K14274,K14645,K20276 - - 0.00000000000001144 88.0
HKD2_k127_2862169_73 PFAM beta-lactamase domain protein - - - 0.00000000000001664 87.0
HKD2_k127_2862169_74 Putative phosphatase (DUF442) - - - 0.00000000000001877 87.0
HKD2_k127_2862169_75 Flagellar rod assembly protein muramidase FlgJ - - - 0.0000000000001004 85.0
HKD2_k127_2862169_76 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.0000000000001874 85.0
HKD2_k127_2862169_77 Belongs to the peptidase S8 family - - - 0.0000000000007256 81.0
HKD2_k127_2862169_78 D-alanyl-D-alanine carboxypeptidase - - - 0.000000000004469 80.0
HKD2_k127_2862169_79 polysaccharide deacetylase - - - 0.00000000007775 74.0
HKD2_k127_2862169_8 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 478.0
HKD2_k127_2862169_80 histidine kinase A domain protein - - - 0.00000002675 68.0
HKD2_k127_2862169_82 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000004944 54.0
HKD2_k127_2862169_83 chlorophyll binding - - - 0.000007485 59.0
HKD2_k127_2862169_84 membrane protein domain K18481 - - 0.0001036 52.0
HKD2_k127_2862169_85 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 0.0002408 56.0
HKD2_k127_2862169_9 Mur ligase family, catalytic domain K01929 - 6.3.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005447 463.0
HKD2_k127_2868784_0 Molydopterin dinucleotide binding domain K08352 - 1.8.5.5 1.596e-301 941.0
HKD2_k127_2868784_1 Tetratricopeptide repeat - - - 3.449e-204 652.0
HKD2_k127_2868784_10 Cation efflux family K16264 - - 0.000000000000000000000000000000000000000000000000000002488 203.0
HKD2_k127_2868784_11 - K07112 - - 0.0000000000000000000000000000000000000000000000000002936 191.0
HKD2_k127_2868784_12 Protein of unknown function (DUF3365) - - - 0.000000000000000000000000000000000000000000000009958 183.0
HKD2_k127_2868784_13 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K02199 - - 0.00000000000000000000000000000000002534 141.0
HKD2_k127_2868784_14 Rhodanese-like domain - - - 0.00000000000000000000000000000002545 137.0
HKD2_k127_2868784_15 long-chain fatty acid transporting porin activity K06076 - - 0.0000000000000000000000000002565 122.0
HKD2_k127_2868784_16 signal transduction histidine kinase K02668,K07709 - 2.7.13.3 0.0000000000000000000000288 115.0
HKD2_k127_2868784_17 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.000000001918 64.0
HKD2_k127_2868784_18 oxidoreductase activity, acting on diphenols and related substances as donors - - - 0.00000004275 66.0
HKD2_k127_2868784_19 Cytochrome b(N-terminal)/b6/petB K00412 - - 0.0000003294 63.0
HKD2_k127_2868784_2 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003396 468.0
HKD2_k127_2868784_3 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003552 465.0
HKD2_k127_2868784_4 PFAM Cys Met metabolism K01760,K01761 - 4.4.1.11,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 460.0
HKD2_k127_2868784_5 Two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005593 359.0
HKD2_k127_2868784_6 PFAM Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004297 284.0
HKD2_k127_2868784_7 4Fe-4S binding domain K04014,K08353,K08358,K16293 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002451 271.0
HKD2_k127_2868784_8 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008144 294.0
HKD2_k127_2868784_9 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000002517 220.0
HKD2_k127_2955005_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 2.346e-235 737.0
HKD2_k127_2955005_1 Belongs to the glycosyl hydrolase 57 family K16149 - 2.4.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006929 476.0
HKD2_k127_2955005_10 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001244 280.0
HKD2_k127_2955005_11 Peptidase family M23 - - - 0.000000000000000000000000000000000000000000000000000000000000000007738 238.0
HKD2_k127_2955005_13 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000002751 179.0
HKD2_k127_2955005_14 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000007749 113.0
HKD2_k127_2955005_15 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000253 113.0
HKD2_k127_2955005_16 Divergent 4Fe-4S mono-cluster - - - 0.0000000000000009873 82.0
HKD2_k127_2955005_17 - - - - 0.0000000000001451 74.0
HKD2_k127_2955005_18 Methyltransferase domain - - - 0.00000000000299 77.0
HKD2_k127_2955005_19 Domain of unknown function (DUF4912) K09942 - - 0.00000000007399 76.0
HKD2_k127_2955005_2 Sigma-54 interaction domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 440.0
HKD2_k127_2955005_3 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009379 429.0
HKD2_k127_2955005_4 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate K01619 - 4.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000993 392.0
HKD2_k127_2955005_5 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001533 365.0
HKD2_k127_2955005_6 4 iron, 4 sulfur cluster binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008631 358.0
HKD2_k127_2955005_7 Pregnancy-associated plasma protein-A - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003237 327.0
HKD2_k127_2955005_8 ArgK protein K07588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 325.0
HKD2_k127_2955005_9 Inner membrane protein CreD K06143 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000184 315.0
HKD2_k127_2981424_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005309 493.0
HKD2_k127_2981424_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 477.0
HKD2_k127_2981424_10 Peptidase family M50 - - - 0.000002986 50.0
HKD2_k127_2981424_11 CSL zinc finger K17867 - - 0.0009692 51.0
HKD2_k127_2981424_2 Pro-kumamolisin, activation domain K08677 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 394.0
HKD2_k127_2981424_3 PFAM peptidase U61 LD-carboxypeptidase A K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000002497 205.0
HKD2_k127_2981424_4 histone H2A K63-linked ubiquitination K10914 - - 0.000000000000000000000000000000000001285 151.0
HKD2_k127_2981424_5 Belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.0000000000000000000000000000006143 128.0
HKD2_k127_2981424_6 Domain of unknown function (DUF4126) - - - 0.0000000000000000004091 94.0
HKD2_k127_2981424_7 - - - - 0.0000000000006089 78.0
HKD2_k127_2981424_8 YacP-like NYN domain - - - 0.0000003189 59.0
HKD2_k127_2981424_9 Lipid A 3-O-deacylase (PagL) - - - 0.000002188 57.0
HKD2_k127_3039970_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003293 354.0
HKD2_k127_3052124_0 Sulfatase K01130 - 3.1.6.1 0.0 1240.0
HKD2_k127_3052124_1 Tricorn protease homolog K08676 - - 0.0 1038.0
HKD2_k127_3052124_10 Protein of unknown function (DUF2950) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002661 395.0
HKD2_k127_3052124_11 MraW methylase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006566 367.0
HKD2_k127_3052124_12 alpha-L-arabinofuranosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008755 384.0
HKD2_k127_3052124_13 MacB-like periplasmic core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009067 336.0
HKD2_k127_3052124_14 AI-2E family transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000022 331.0
HKD2_k127_3052124_15 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005017 329.0
HKD2_k127_3052124_16 Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA K06969 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 308.0
HKD2_k127_3052124_17 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 315.0
HKD2_k127_3052124_18 Phage Tail Collar Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003251 274.0
HKD2_k127_3052124_19 Phage Tail Collar Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002323 268.0
HKD2_k127_3052124_2 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 4.788e-243 762.0
HKD2_k127_3052124_20 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002308 278.0
HKD2_k127_3052124_21 Microcystin-dependent protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006056 249.0
HKD2_k127_3052124_22 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000004887 241.0
HKD2_k127_3052124_23 FtsX-like permease family K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000001954 251.0
HKD2_k127_3052124_24 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000004936 228.0
HKD2_k127_3052124_25 type I phosphodiesterase nucleotide pyrophosphatase - GO:0003674,GO:0003824,GO:0004035,GO:0004346,GO:0005488,GO:0005575,GO:0005623,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008877,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046872,GO:0046914,GO:0050308,GO:0050309,GO:0098519 - 0.00000000000000000000000000000000000000000000000000001526 210.0
HKD2_k127_3052124_26 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000004383 196.0
HKD2_k127_3052124_27 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000004584 184.0
HKD2_k127_3052124_28 COG2931 RTX toxins and related Ca2 -binding proteins - - - 0.00000000000000000000000000000000000000000007274 185.0
HKD2_k127_3052124_29 - - - - 0.0000000000000000000003955 98.0
HKD2_k127_3052124_3 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 1.688e-230 741.0
HKD2_k127_3052124_30 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000102 103.0
HKD2_k127_3052124_31 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.00000000000000000003564 104.0
HKD2_k127_3052124_32 Glycosyltransferase family 87 - - - 0.0000000000001598 86.0
HKD2_k127_3052124_33 Tetratricopeptide repeat - - - 0.00000000003795 72.0
HKD2_k127_3052124_34 TIGRFAM VWFA-related Acidobacterial domain - - - 0.000000000434 74.0
HKD2_k127_3052124_35 Transcriptional regulator - - - 0.00000001049 68.0
HKD2_k127_3052124_37 Type II IV secretion system protein K02652 - - 0.00001662 56.0
HKD2_k127_3052124_38 Leucine-rich repeat (LRR) protein - - - 0.00002125 59.0
HKD2_k127_3052124_39 - - - - 0.0002075 48.0
HKD2_k127_3052124_4 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 612.0
HKD2_k127_3052124_5 IgA Peptidase M64 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008476 492.0
HKD2_k127_3052124_6 OPT oligopeptide transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 498.0
HKD2_k127_3052124_7 chloride channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002348 481.0
HKD2_k127_3052124_8 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009244 464.0
HKD2_k127_3052124_9 Protein of unknown function (DUF3300) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002246 389.0
HKD2_k127_3125537_0 Tricorn protease C1 domain K08676 - - 3.133e-309 994.0
HKD2_k127_3125537_1 PFAM Protein synthesis factor, GTP-binding K06207 - - 1.052e-251 790.0
HKD2_k127_3125537_10 Transport of potassium into the cell - - - 0.0000000000000000000000000000000000000000001198 165.0
HKD2_k127_3125537_11 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.00000000000000000000000000000000000000005326 160.0
HKD2_k127_3125537_12 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567,K10778 - 2.1.1.63 0.0000000000000000000000000000000000000001211 165.0
HKD2_k127_3125537_13 Spore Coat K01790 - 5.1.3.13 0.000000000000000000000000009424 117.0
HKD2_k127_3125537_14 CpeT/CpcT family (DUF1001) - - - 0.00000000000000000000000005001 122.0
HKD2_k127_3125537_15 Psort location Cytoplasmic, score - - - 0.0000000000000000782 89.0
HKD2_k127_3125537_16 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000000001506 89.0
HKD2_k127_3125537_17 guanyl-nucleotide exchange factor activity K05349 - 3.2.1.21 0.0000000003083 68.0
HKD2_k127_3125537_18 - - - - 0.0000000966 61.0
HKD2_k127_3125537_19 antisigma factor binding - - - 0.00001016 52.0
HKD2_k127_3125537_2 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003051 604.0
HKD2_k127_3125537_20 Protein of unknown function (DUF2723) - - - 0.00002833 57.0
HKD2_k127_3125537_21 - - - - 0.0001273 54.0
HKD2_k127_3125537_3 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 593.0
HKD2_k127_3125537_4 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005299 421.0
HKD2_k127_3125537_5 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 351.0
HKD2_k127_3125537_6 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 332.0
HKD2_k127_3125537_7 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002413 290.0
HKD2_k127_3125537_8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000004787 271.0
HKD2_k127_3125537_9 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970,K00974 - 2.7.7.19,2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000005371 280.0
HKD2_k127_3127596_0 Bacterial periplasmic substrate-binding proteins K02029,K02030 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 426.0
HKD2_k127_3127596_1 phosphatidylethanolamine metabolic process K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 338.0
HKD2_k127_3127596_2 polysaccharide deacetylase - - - 0.000000000000004388 85.0
HKD2_k127_3162413_0 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006784 616.0
HKD2_k127_3162413_1 helicase superfamily c-terminal domain K03732 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002423 449.0
HKD2_k127_3162413_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 385.0
HKD2_k127_3162413_3 Belongs to the aldehyde dehydrogenase family K00135,K22445 - 1.2.1.16,1.2.1.20,1.2.1.79,1.2.99.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003691 391.0
HKD2_k127_3162413_4 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000001603 226.0
HKD2_k127_3162413_5 Alpha beta hydrolase - - - 0.000000000000000000000003324 112.0
HKD2_k127_3162413_6 Membrane - - - 0.000000000000005328 91.0
HKD2_k127_3162413_7 Molybdenum ABC transporter K02020 - - 0.000000005198 66.0
HKD2_k127_3162413_8 Tetratricopeptide TPR_2 repeat protein - - - 0.0006272 51.0
HKD2_k127_3193456_0 Sigma-54 interaction domain K03405 - 6.6.1.1 0.00001579 49.0
HKD2_k127_3193456_1 Probably functions as a manganese efflux pump - - - 0.000218 54.0
HKD2_k127_3253576_0 Alcohol dehydrogenase GroES-like domain K13979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002245 527.0
HKD2_k127_3253576_1 PFAM FMN-dependent alpha-hydroxy acid dehydrogenase K00101,K00467,K16422 - 1.1.2.3,1.1.3.46,1.13.12.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004631 426.0
HKD2_k127_3253576_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005327 375.0
HKD2_k127_3253576_3 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 333.0
HKD2_k127_3253576_4 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000000000000505 214.0
HKD2_k127_3253576_6 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000278 179.0
HKD2_k127_3253576_7 Pfam Polyketide cyclase dehydrase and lipid transport - - - 0.00000000000000000000000000000000000000000000000587 191.0
HKD2_k127_3253576_8 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874,K01890,K04566,K06878 - 6.1.1.10,6.1.1.20,6.1.1.6 0.0000000000000000000000000000000000000000001313 163.0
HKD2_k127_3253576_9 PFAM CoA-binding domain protein K06929 - - 0.00000000000000000000000000000000006221 139.0
HKD2_k127_3283737_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 1.592e-295 920.0
HKD2_k127_3283737_1 ABC transporter - - - 3.496e-259 809.0
HKD2_k127_3283737_10 [isocitrate dehydrogenase (NADP+)] phosphatase activity K00906 GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 609.0
HKD2_k127_3283737_11 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 604.0
HKD2_k127_3283737_12 ABC transporter, transmembrane K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002797 575.0
HKD2_k127_3283737_13 Belongs to the GarS family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005263 518.0
HKD2_k127_3283737_14 D-aminoacylase domain protein K01465,K06015 - 3.5.1.81,3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004559 516.0
HKD2_k127_3283737_15 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007569 500.0
HKD2_k127_3283737_16 Aminotransferase class I and II K14267 - 2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 443.0
HKD2_k127_3283737_17 Protein of unknown function (DUF1015) K00262 - 1.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 424.0
HKD2_k127_3283737_18 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005732 424.0
HKD2_k127_3283737_19 Glycosyl transferase, family 2 K21349 - 2.4.1.268 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 423.0
HKD2_k127_3283737_2 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 7.415e-233 729.0
HKD2_k127_3283737_20 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003488 439.0
HKD2_k127_3283737_21 transferase activity, transferring glycosyl groups K13693 - 2.4.1.266 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 396.0
HKD2_k127_3283737_22 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 392.0
HKD2_k127_3283737_23 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006861 367.0
HKD2_k127_3283737_24 Osmosensitive K channel His kinase sensor K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 347.0
HKD2_k127_3283737_25 stress-induced mitochondrial fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002424 344.0
HKD2_k127_3283737_26 aromatic amino acid beta-eliminating lyase threonine aldolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002247 330.0
HKD2_k127_3283737_27 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 317.0
HKD2_k127_3283737_28 PFAM glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 290.0
HKD2_k127_3283737_29 3-beta hydroxysteroid dehydrogenase/isomerase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 317.0
HKD2_k127_3283737_3 FGGY family of carbohydrate kinases, N-terminal domain - - - 1.349e-231 753.0
HKD2_k127_3283737_30 ATP-binding region ATPase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007262 287.0
HKD2_k127_3283737_31 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000007378 286.0
HKD2_k127_3283737_32 Transposase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001443 274.0
HKD2_k127_3283737_33 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000006002 235.0
HKD2_k127_3283737_34 Doubled CXXCH motif (Paired_CXXCH_1) - - - 0.00000000000000000000000000000000000000000000000000000000000019 222.0
HKD2_k127_3283737_35 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000005082 213.0
HKD2_k127_3283737_36 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000000000000001078 213.0
HKD2_k127_3283737_37 Product type r regulator - - - 0.0000000000000000000000000000000000000000000000000000000007121 224.0
HKD2_k127_3283737_38 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.00000000000000000000000000000000000000000000000000000008624 219.0
HKD2_k127_3283737_39 COG0515 Serine threonine protein K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000007219 211.0
HKD2_k127_3283737_4 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 6.533e-220 695.0
HKD2_k127_3283737_40 Response regulator receiver K07667 - - 0.00000000000000000000000000000000000000000000000000001553 208.0
HKD2_k127_3283737_41 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.00000000000000000000000000000000000000000000003188 184.0
HKD2_k127_3283737_42 cytokinin biosynthetic process K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000003859 176.0
HKD2_k127_3283737_43 Ferritin-like domain K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000001674 191.0
HKD2_k127_3283737_44 Aminoacyl-tRNA editing domain K19055 - - 0.0000000000000000000000000000000000000000000006722 172.0
HKD2_k127_3283737_45 PFAM OsmC family protein - - - 0.000000000000000000000000000000000000000000001158 169.0
HKD2_k127_3283737_46 Histidine kinase K07646 - 2.7.13.3 0.000000000000000000000000000000000000000000001324 183.0
HKD2_k127_3283737_47 - - - - 0.000000000000000000000000000000000000000000004535 186.0
HKD2_k127_3283737_48 Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000002256 151.0
HKD2_k127_3283737_49 Nitrous oxide-stimulated promoter - - - 0.0000000000000000000000000000000000001715 145.0
HKD2_k127_3283737_5 oligopeptide transport K03305 - - 5.211e-218 699.0
HKD2_k127_3283737_50 helix_turn_helix gluconate operon transcriptional repressor K07979 - - 0.00000000000000000000000000000000001487 139.0
HKD2_k127_3283737_51 Methyltransferase type 12 - - - 0.0000000000000000000000000000000004675 152.0
HKD2_k127_3283737_52 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000005095 147.0
HKD2_k127_3283737_53 NUDIX domain - - - 0.00000000000000000000000000000001154 134.0
HKD2_k127_3283737_54 Calcineurin-like phosphoesterase K03269 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 0.00000000000000000000000000000002105 136.0
HKD2_k127_3283737_55 - - - - 0.00000000000000000000000000000005755 132.0
HKD2_k127_3283737_56 Lipocalin-like domain - - - 0.000000000000000000000000000001079 126.0
HKD2_k127_3283737_57 haloacid dehalogenase-like hydrolase K07026 - 3.1.3.70 0.00000000000000000000000000000712 130.0
HKD2_k127_3283737_58 integral membrane protein - - - 0.0000000000000000000000000009539 130.0
HKD2_k127_3283737_59 Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000001859 103.0
HKD2_k127_3283737_6 amino acid - - - 5.645e-216 689.0
HKD2_k127_3283737_60 RNA recognition motif - - - 0.00000000000000000001629 105.0
HKD2_k127_3283737_61 transmembrane transport - - - 0.00000000000000000002737 107.0
HKD2_k127_3283737_62 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000001058 92.0
HKD2_k127_3283737_63 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.000000000000000009614 96.0
HKD2_k127_3283737_64 Protein of unknown function, DUF255 - - - 0.0000000000000009577 84.0
HKD2_k127_3283737_65 Membrane - - - 0.000000000000003251 90.0
HKD2_k127_3283737_66 response regulator K02282,K07705 - - 0.00000000000000513 81.0
HKD2_k127_3283737_67 aspartate kinase activity - - - 0.0000000000004509 76.0
HKD2_k127_3283737_68 chitinase K01183 - 3.2.1.14 0.000000000003789 78.0
HKD2_k127_3283737_69 chitinase K01183 - 3.2.1.14 0.000000000007734 78.0
HKD2_k127_3283737_7 Tricorn protease C1 domain K08676 - - 1.864e-211 710.0
HKD2_k127_3283737_70 - - - - 0.0000000002188 74.0
HKD2_k127_3283737_71 Membrane - - - 0.0000000002241 74.0
HKD2_k127_3283737_73 PFAM glycosyl transferase family 39 - - - 0.00002994 58.0
HKD2_k127_3283737_8 Phosphoesterase family - - - 1.728e-194 634.0
HKD2_k127_3283737_9 FAD linked oxidases, C-terminal domain K00803 - 2.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003726 627.0
HKD2_k127_3300286_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 8.587e-281 879.0
HKD2_k127_3300286_1 Seven times multi-haem cytochrome CxxCH - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 516.0
HKD2_k127_3300286_10 Uncharacterized membrane protein (DUF2298) - - - 0.00000000000000000000000000000000000000000002447 187.0
HKD2_k127_3300286_11 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.000000000000000000000000000000000000000001149 181.0
HKD2_k127_3300286_12 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000000001089 172.0
HKD2_k127_3300286_13 regulation of endocannabinoid signaling pathway - GO:0003674,GO:0003824,GO:0016787 - 0.00000000000000000004835 101.0
HKD2_k127_3300286_14 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.0000000000000000009074 102.0
HKD2_k127_3300286_15 - - - - 0.000000000000000001459 99.0
HKD2_k127_3300286_16 Fatty acid desaturase - - - 0.00000000000001246 85.0
HKD2_k127_3300286_17 C-terminal four TMM region of protein-O-mannosyltransferase K00728 - 2.4.1.109 0.0001091 56.0
HKD2_k127_3300286_2 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009175 504.0
HKD2_k127_3300286_3 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002195 429.0
HKD2_k127_3300286_4 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 345.0
HKD2_k127_3300286_5 PFAM glycosyl transferase family 2 K20534 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004686 342.0
HKD2_k127_3300286_6 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K00254,K02823,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 339.0
HKD2_k127_3300286_7 Protein of unknown function (DUF2911) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 332.0
HKD2_k127_3300286_8 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002048 334.0
HKD2_k127_3300286_9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.000000000000000000000000000000000000000000000000000003198 210.0
HKD2_k127_3312863_0 Belongs to the glycosyl hydrolase 57 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 452.0
HKD2_k127_3312863_1 ADP-ribosylation factor family K06883 GO:0008150,GO:0032879,GO:0032880,GO:0050789,GO:0065007 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001207 304.0
HKD2_k127_3312863_2 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006421 299.0
HKD2_k127_3312863_3 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000004855 228.0
HKD2_k127_3312863_4 Roadblock/LC7 domain - - - 0.000000000000000000000000000000000000000000000000000002543 205.0
HKD2_k127_3312863_5 FAD linked oxidases, C-terminal domain K18930 - - 0.0000000000000000000000000000004723 142.0
HKD2_k127_343265_0 Carbamoyl-phosphate synthetase ammonia chain K01955 GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.0 1337.0
HKD2_k127_343265_1 PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 3.905e-292 913.0
HKD2_k127_343265_10 - - - - 0.000000000000000000000000000000000000000000000000002833 188.0
HKD2_k127_343265_11 Putative ABC exporter - - - 0.00000000000000000000000000000000000000000000000007913 203.0
HKD2_k127_343265_12 Bacterial protein of unknown function (DUF937) - - - 0.0000000000000000000000000000001067 128.0
HKD2_k127_343265_13 lactoylglutathione lyase activity - - - 0.0000000000000000000006242 103.0
HKD2_k127_343265_14 Peptidase family M23 - - - 0.00000000001476 77.0
HKD2_k127_343265_15 - - - - 0.0000000003968 73.0
HKD2_k127_343265_16 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00000000634 70.0
HKD2_k127_343265_17 Pfam O-Antigen Polymerase - - - 0.000004644 61.0
HKD2_k127_343265_2 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 464.0
HKD2_k127_343265_3 epimerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007573 448.0
HKD2_k127_343265_4 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004315 375.0
HKD2_k127_343265_5 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007678 358.0
HKD2_k127_343265_6 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 315.0
HKD2_k127_343265_7 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000007839 248.0
HKD2_k127_343265_8 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000009504 240.0
HKD2_k127_343265_9 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.0000000000000000000000000000000000000000000000000002878 209.0
HKD2_k127_3586878_0 VIT family - - - 0.000000000000000000000000000000000000000000000000000000001719 210.0
HKD2_k127_3586878_1 - - - - 0.000000000000000000000000000000000000000006886 171.0
HKD2_k127_3586878_2 Protein of unknown function (DUF2950) - - - 0.00000000000001078 74.0
HKD2_k127_370239_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 552.0
HKD2_k127_370239_1 Glycosyl transferase 4-like K00754 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008974 398.0
HKD2_k127_370239_10 RDD family - - - 0.0004048 53.0
HKD2_k127_370239_2 GlcNAc-PI de-N-acetylase K01463 - - 0.00000000000000000000000000000000000000000000000001032 205.0
HKD2_k127_370239_3 PFAM adenosine AMP deaminase K01488 - 3.5.4.4 0.00000000000000000000000000000000000000000001509 186.0
HKD2_k127_370239_4 Bacillithiol biosynthesis BshC K22136 - - 0.00000000000000000000000000000000003447 153.0
HKD2_k127_370239_5 - - - - 0.00000000000000000004263 100.0
HKD2_k127_370239_6 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.00000000000000158 89.0
HKD2_k127_370239_7 Preprotein translocase SecG subunit K03075 - - 0.000000000000002151 83.0
HKD2_k127_370239_8 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 0.000001149 50.0
HKD2_k127_370239_9 zinc-ribbon domain - - - 0.0001533 51.0
HKD2_k127_3775127_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 4.195e-238 747.0
HKD2_k127_3775127_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008827 402.0
HKD2_k127_3775127_10 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000007641 66.0
HKD2_k127_3775127_11 Bacterial membrane protein, YfhO - - - 0.00007934 56.0
HKD2_k127_3775127_2 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 375.0
HKD2_k127_3775127_3 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000002512 189.0
HKD2_k127_3775127_4 hydrolase, HAD-superfamily, subfamily IIIA K03273 - 3.1.3.82,3.1.3.83 0.00000000000000000000000000000000000000000000001239 180.0
HKD2_k127_3775127_5 Glycosyltransferase like family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000008105 181.0
HKD2_k127_3775127_6 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000001316 139.0
HKD2_k127_3775127_7 NmrA-like family - - - 0.0000000000000000000000000002594 133.0
HKD2_k127_3775127_8 Methionine biosynthesis protein MetW - - - 0.0000000000000004598 89.0
HKD2_k127_3775127_9 Methyltransferase domain - - - 0.00000000005892 74.0
HKD2_k127_3823843_0 AcrB/AcrD/AcrF family K15726 - - 0.0 1032.0
HKD2_k127_3823843_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007595 567.0
HKD2_k127_3823843_10 Psort location Cytoplasmic, score K00008,K00060 - 1.1.1.103,1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000003141 251.0
HKD2_k127_3823843_11 rRNA methylase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000001069 258.0
HKD2_k127_3823843_12 surface antigen - - - 0.00000000000000000000000000000000000000000000000000000000000000000005715 264.0
HKD2_k127_3823843_13 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000005356 212.0
HKD2_k127_3823843_14 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K15727 - - 0.00000000000000000000000000000000000000000000000005855 203.0
HKD2_k127_3823843_15 acetyltransferase - - - 0.000000000000000000000000000000000000000000001028 174.0
HKD2_k127_3823843_16 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000000000000000000004663 180.0
HKD2_k127_3823843_17 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000001274 153.0
HKD2_k127_3823843_18 Molybdenum cofactor biosynthesis K03638,K03831 - 2.7.7.75 0.00000000000000000000000000000000000007616 149.0
HKD2_k127_3823843_19 glycosyl transferase - - - 0.00000000000000000000000000000008036 132.0
HKD2_k127_3823843_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 530.0
HKD2_k127_3823843_20 PFAM Outer membrane efflux protein K15725 - - 0.000000000000000000000004353 116.0
HKD2_k127_3823843_21 Photosynthetic reaction centre cytochrome C subunit - - - 0.000000000000000000000009037 114.0
HKD2_k127_3823843_22 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.0000000000000001081 94.0
HKD2_k127_3823843_23 - - - - 0.00000000000004064 85.0
HKD2_k127_3823843_3 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 460.0
HKD2_k127_3823843_4 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 413.0
HKD2_k127_3823843_5 TIGRFAM cation diffusion facilitator family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 352.0
HKD2_k127_3823843_6 GMC oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 351.0
HKD2_k127_3823843_7 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 331.0
HKD2_k127_3823843_8 Alcohol dehydrogenase GroES-like domain K00008 - 1.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005844 286.0
HKD2_k127_3823843_9 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639,K20967 - 4.1.99.22,4.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000004653 267.0
HKD2_k127_3842139_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 461.0
HKD2_k127_3842139_1 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002208 317.0
HKD2_k127_3842139_2 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000002625 154.0
HKD2_k127_3842139_3 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 0.00000000000000000000000000000001535 142.0
HKD2_k127_3842139_4 iron ion homeostasis - - - 0.00000000000000000000000000000005646 143.0
HKD2_k127_3842139_5 Signal Transduction Histidine Kinase - - - 0.0000000000000000000000002442 117.0
HKD2_k127_3842139_6 Fungalysin metallopeptidase (M36) - - - 0.0000000000001948 86.0
HKD2_k127_3890841_0 Cell shape determining protein MreB Mrl K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003083 292.0
HKD2_k127_3890841_1 Bacterial periplasmic substrate-binding proteins K02029,K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004736 248.0
HKD2_k127_3890841_2 AAA domain, putative AbiEii toxin, Type IV TA system K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000001662 242.0
HKD2_k127_3890841_3 Ami_3 K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000007579 183.0
HKD2_k127_3902380_0 Acetylornithine deacetylase Succinyl-diaminopimelate - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003196 278.0
HKD2_k127_3904895_0 aldo keto reductase K05275 - 1.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005785 522.0
HKD2_k127_3904895_1 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 435.0
HKD2_k127_3904895_2 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 368.0
HKD2_k127_3904895_3 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004431 297.0
HKD2_k127_3904895_4 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000009323 245.0
HKD2_k127_3938285_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0 1300.0
HKD2_k127_3938285_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08352 - 1.8.5.5 5.924e-245 773.0
HKD2_k127_3938285_10 IstB-like ATP binding protein K02315 - - 0.000000000000000000000000000000000000000000000000003616 190.0
HKD2_k127_3938285_11 Stage II sporulation protein K06381 - - 0.0000000000000000000000000000000000000000000000001119 205.0
HKD2_k127_3938285_12 PFAM regulatory protein, MerR K13640 - - 0.00000000000000000000000000001964 122.0
HKD2_k127_3938285_13 - - - - 0.0000000000000003858 90.0
HKD2_k127_3938285_14 - - - - 0.000000000006914 80.0
HKD2_k127_3938285_15 PA14 domain - - - 0.000000008964 67.0
HKD2_k127_3938285_2 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01667,K01668 - 4.1.99.1,4.1.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001553 638.0
HKD2_k127_3938285_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 526.0
HKD2_k127_3938285_4 Protein of unknown function (DUF2867) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008493 464.0
HKD2_k127_3938285_5 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007595 385.0
HKD2_k127_3938285_7 Insulinase (Peptidase family M16) - - - 0.000000000000000000000000000000000000000000000000000000000000000000002492 264.0
HKD2_k127_3938285_8 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000001628 236.0
HKD2_k127_3938285_9 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000002188 203.0
HKD2_k127_3953348_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005967 541.0
HKD2_k127_3953348_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 420.0
HKD2_k127_3953348_10 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000001535 167.0
HKD2_k127_3953348_11 PFAM Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000003118 158.0
HKD2_k127_3953348_12 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 0.000000000000000000000000000003353 137.0
HKD2_k127_3953348_2 peptidase activity, acting on L-amino acid peptides K07004,K09955 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 428.0
HKD2_k127_3953348_3 Threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002694 339.0
HKD2_k127_3953348_4 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 305.0
HKD2_k127_3953348_5 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 301.0
HKD2_k127_3953348_6 COG0491 Zn-dependent hydrolases, including glyoxylases K01069 GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000005082 225.0
HKD2_k127_3953348_7 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000001759 233.0
HKD2_k127_3953348_8 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.0000000000000000000000000000000000000000000000000000001343 208.0
HKD2_k127_3953348_9 Belongs to the ClpA ClpB family K03696 - - 0.00000000000000000000000000000000000000000000000005226 183.0
HKD2_k127_4019787_0 TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family K15553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006418 436.0
HKD2_k127_4019787_1 Binding-protein-dependent transport system inner membrane component K02050,K15554 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 319.0
HKD2_k127_4019787_2 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002264 274.0
HKD2_k127_4019787_3 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008081 267.0
HKD2_k127_4019787_4 ABC transporter K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001715 259.0
HKD2_k127_4019787_5 Belongs to the short-chain dehydrogenases reductases (SDR) family K00059,K07124 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000002227 205.0
HKD2_k127_4019787_6 Diguanylate cyclase K20959 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032879,GO:0040012,GO:0040013,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0065007,GO:0071944,GO:1902021,GO:1902201,GO:2000145,GO:2000146 2.7.7.65 0.0000000000000000000000000000000002715 151.0
HKD2_k127_4019787_7 repeat-containing protein - - - 0.0003092 53.0
HKD2_k127_4073793_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 600.0
HKD2_k127_4073793_1 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008087 578.0
HKD2_k127_4073793_10 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000003955 103.0
HKD2_k127_4073793_11 domain protein - - - 0.0000000000001051 85.0
HKD2_k127_4073793_12 acyl carrier protein - - - 0.000000001279 62.0
HKD2_k127_4073793_2 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000038 492.0
HKD2_k127_4073793_3 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 451.0
HKD2_k127_4073793_4 ABC transporter K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000607 384.0
HKD2_k127_4073793_5 PFAM Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000823 359.0
HKD2_k127_4073793_6 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily K03430 - 2.6.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 347.0
HKD2_k127_4073793_7 Binding-protein-dependent transport system inner membrane component K02018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002234 299.0
HKD2_k127_4073793_8 Bacterial extracellular solute-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001488 250.0
HKD2_k127_4073793_9 PFAM CBS domain containing protein - - - 0.000000000000000000001961 106.0
HKD2_k127_4098465_0 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 447.0
HKD2_k127_414685_0 cellulose binding - - - 2.302e-247 782.0
HKD2_k127_414685_1 PFAM Rhomboid family - - - 0.0000000000000002514 92.0
HKD2_k127_4152610_0 Cytochrome C oxidase subunit II, periplasmic domain K00376 - 1.7.2.4 0.0 1097.0
HKD2_k127_4152610_1 Hydrolase CocE NonD family - - - 5.376e-320 992.0
HKD2_k127_4152610_10 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001986 612.0
HKD2_k127_4152610_11 Periplasmic copper-binding protein (NosD) K07218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 618.0
HKD2_k127_4152610_12 Belongs to the RtcB family K14415,K18148 - 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005302 610.0
HKD2_k127_4152610_13 DEAD-like helicases superfamily K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 607.0
HKD2_k127_4152610_14 peptidase dimerisation domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007593 584.0
HKD2_k127_4152610_15 cell shape determining protein MreB K03569 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 530.0
HKD2_k127_4152610_16 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 586.0
HKD2_k127_4152610_17 flavin-nucleotide-binding protein structurally related to pyridoxine 5-phosphate oxidase K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 539.0
HKD2_k127_4152610_18 signal peptide peptidase K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003917 514.0
HKD2_k127_4152610_19 Ribonuclease E/G family K08300,K08301 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007675 505.0
HKD2_k127_4152610_2 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 3.67e-302 942.0
HKD2_k127_4152610_20 Domains REC, sigma54 interaction, HTH8 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000382 478.0
HKD2_k127_4152610_21 Penicillin-binding protein, dimerisation domain K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002346 444.0
HKD2_k127_4152610_22 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005228 426.0
HKD2_k127_4152610_23 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008832 416.0
HKD2_k127_4152610_24 Cytochrome d ubiquinol oxidase, subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007259 390.0
HKD2_k127_4152610_25 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000279 402.0
HKD2_k127_4152610_26 ABC transporter K01990,K19340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 368.0
HKD2_k127_4152610_27 virion core protein, lumpy skin disease virus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008811 349.0
HKD2_k127_4152610_28 ABC-2 family transporter protein K19341 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 328.0
HKD2_k127_4152610_29 Calcineurin-like phosphoesterase superfamily domain K07098 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007147 310.0
HKD2_k127_4152610_3 Peptidase S46 - - - 1.817e-288 903.0
HKD2_k127_4152610_30 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 298.0
HKD2_k127_4152610_31 Histidine-specific methyltransferase, SAM-dependent K18911 - 2.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005055 295.0
HKD2_k127_4152610_32 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001084 274.0
HKD2_k127_4152610_33 tRNA wobble cytosine modification - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001768 281.0
HKD2_k127_4152610_34 lipoprotein involved in nitrous oxide reduction - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008163 263.0
HKD2_k127_4152610_35 Putative cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001648 264.0
HKD2_k127_4152610_36 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002505 280.0
HKD2_k127_4152610_37 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002632 278.0
HKD2_k127_4152610_38 Isochorismatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003531 251.0
HKD2_k127_4152610_39 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005575 260.0
HKD2_k127_4152610_4 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 3.496e-279 889.0
HKD2_k127_4152610_40 SurA N-terminal domain K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000001386 263.0
HKD2_k127_4152610_41 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.00000000000000000000000000000000000000000000000000000000000001715 226.0
HKD2_k127_4152610_42 NAT, N-acetyltransferase, of N-acetylglutamate synthase K22478 - 2.3.1.1,2.7.2.8 0.00000000000000000000000000000000000000000000000000000001936 216.0
HKD2_k127_4152610_43 Nicotinamide mononucleotide transporter K03811 - - 0.00000000000000000000000000000000000000000000000000000003854 204.0
HKD2_k127_4152610_44 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000002876 203.0
HKD2_k127_4152610_45 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000001961 194.0
HKD2_k127_4152610_46 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000008427 197.0
HKD2_k127_4152610_47 Putative diguanylate phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000004026 202.0
HKD2_k127_4152610_48 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000355 184.0
HKD2_k127_4152610_49 lipoprotein involved in nitrous oxide reduction K19342 - - 0.000000000000000000000000000000000000000000005027 176.0
HKD2_k127_4152610_5 Peptidase family M1 domain - - - 3.118e-227 739.0
HKD2_k127_4152610_50 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000005344 183.0
HKD2_k127_4152610_51 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000006872 164.0
HKD2_k127_4152610_52 Bacterial PH domain - - - 0.0000000000000000000000000000000000000002987 155.0
HKD2_k127_4152610_53 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.00000000000000000000000000000000003464 145.0
HKD2_k127_4152610_54 PFAM Archease protein family (DUF101 UPF0211) K00974 - 2.7.7.72 0.00000000000000000000000000000000004197 141.0
HKD2_k127_4152610_55 TIGRFAM diguanylate cyclase (GGDEF) domain - - - 0.000000000000000000000000000000001671 144.0
HKD2_k127_4152610_56 AAA domain - - - 0.00000000000000000000000000000000485 142.0
HKD2_k127_4152610_57 enzyme binding K00567,K07443 - 2.1.1.63 0.00000000000000000000000000000002623 134.0
HKD2_k127_4152610_58 Citrate transporter - - - 0.00000000000000000000000000005149 130.0
HKD2_k127_4152610_59 pyridoxamine 5-phosphate - - - 0.00000000000000000000000000006824 121.0
HKD2_k127_4152610_6 acyl-CoA dehydrogenase K00249 - 1.3.8.7 3.043e-226 713.0
HKD2_k127_4152610_60 Diacylglycerol kinase catalytic domain (presumed) - - - 0.000000000000000000000000008853 121.0
HKD2_k127_4152610_61 4Fe-4S binding domain - - - 0.0000000000000000000000001122 125.0
HKD2_k127_4152610_62 Universal stress protein family - - - 0.0000000000000000000000001389 118.0
HKD2_k127_4152610_63 Photosynthesis system II assembly factor YCF48 - - - 0.000000000000000000000007832 113.0
HKD2_k127_4152610_64 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.00000000000000000000001401 111.0
HKD2_k127_4152610_65 Histidine kinase K10681 - 2.7.13.3 0.0000000000000000000001218 111.0
HKD2_k127_4152610_66 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000005444 109.0
HKD2_k127_4152610_67 PFAM FecR protein - - - 0.00000000000000000000917 106.0
HKD2_k127_4152610_68 Elongator protein 3, MiaB family, Radical SAM K04069 - 1.97.1.4 0.00000000000000000007817 100.0
HKD2_k127_4152610_69 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000002513 98.0
HKD2_k127_4152610_7 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 1.807e-223 702.0
HKD2_k127_4152610_71 polysaccharide deacetylase - - - 0.000000000000000019 96.0
HKD2_k127_4152610_72 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.00000000000000002217 91.0
HKD2_k127_4152610_73 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000003944 94.0
HKD2_k127_4152610_74 polysaccharide deacetylase K15531 - 3.2.1.156 0.0000000000000002616 90.0
HKD2_k127_4152610_75 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000002275 67.0
HKD2_k127_4152610_76 Histidine kinase A domain protein - - - 0.00000001528 63.0
HKD2_k127_4152610_77 Peptidase family M28 - - - 0.00000001657 67.0
HKD2_k127_4152610_78 - - - - 0.0000001361 61.0
HKD2_k127_4152610_79 DNA binding - - - 0.0000003065 55.0
HKD2_k127_4152610_8 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 2.572e-199 633.0
HKD2_k127_4152610_80 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00002852 57.0
HKD2_k127_4152610_82 PFAM GGDEF domain containing protein - - - 0.0002712 53.0
HKD2_k127_4152610_9 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 620.0
HKD2_k127_4159883_0 signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005285 296.0
HKD2_k127_4212092_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 1.081e-291 913.0
HKD2_k127_4212092_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 2.459e-232 758.0
HKD2_k127_4212092_10 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002234 340.0
HKD2_k127_4212092_11 Por secretion system C-terminal sorting domain-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000238 342.0
HKD2_k127_4212092_12 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007772 286.0
HKD2_k127_4212092_13 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K00090 - 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000752 273.0
HKD2_k127_4212092_14 ABC transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004089 262.0
HKD2_k127_4212092_15 endonuclease III K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000001582 246.0
HKD2_k127_4212092_16 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000205 241.0
HKD2_k127_4212092_17 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000009263 214.0
HKD2_k127_4212092_18 Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase - - - 0.000000000000000000000000000000000000000000000000000001749 214.0
HKD2_k127_4212092_19 COG1131 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000003 198.0
HKD2_k127_4212092_2 Aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003242 597.0
HKD2_k127_4212092_20 Putative beta-barrel porin-2, OmpL-like. bbp2 - - - 0.00000000000000000000000000000000000000000000000007247 193.0
HKD2_k127_4212092_21 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000006644 187.0
HKD2_k127_4212092_22 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016151,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0032501,GO:0036211,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046777,GO:0046872,GO:0046914,GO:0048871,GO:0050897,GO:0065007,GO:0065008,GO:0071704,GO:0097009,GO:0140096,GO:1901564 2.7.11.1 0.00000000000000000000000000000000000000000008574 178.0
HKD2_k127_4212092_23 Phosphate acyltransferases K00655 - 2.3.1.51 0.0000000000000000000000000000000000000177 154.0
HKD2_k127_4212092_24 MlaD protein K02067 - - 0.000000000000000000000000000000000003141 158.0
HKD2_k127_4212092_25 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000125 153.0
HKD2_k127_4212092_26 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000001271 138.0
HKD2_k127_4212092_27 Sigma-70, region 4 K03088 - - 0.0000000000000000000000000000005264 136.0
HKD2_k127_4212092_28 Winged helix DNA-binding domain - - - 0.00000000000000000000000000004541 121.0
HKD2_k127_4212092_29 Tetratricopeptide repeat - - - 0.00000000000000000000000006309 125.0
HKD2_k127_4212092_3 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 524.0
HKD2_k127_4212092_30 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000007728 106.0
HKD2_k127_4212092_31 Putative ATP-binding cassette K01992 - - 0.0000000000000000001604 104.0
HKD2_k127_4212092_32 NAD dependent epimerase dehydratase K08679 - 5.1.3.6 0.00000000000003778 87.0
HKD2_k127_4212092_33 methyltransferase - - - 0.0000000434 62.0
HKD2_k127_4212092_34 RDD family - - - 0.000001035 61.0
HKD2_k127_4212092_35 PFAM CHAD domain containing protein - - - 0.000001285 59.0
HKD2_k127_4212092_36 Glycosyl transferases group 1 - - - 0.000003059 61.0
HKD2_k127_4212092_37 histone H2A K63-linked ubiquitination - GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000004192 59.0
HKD2_k127_4212092_38 - - - - 0.00002366 57.0
HKD2_k127_4212092_39 long-chain fatty acid transport protein K06076 GO:0003674,GO:0005215,GO:0005319,GO:0005324,GO:0005342,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0009279,GO:0010876,GO:0015075,GO:0015245,GO:0015267,GO:0015288,GO:0015318,GO:0015483,GO:0015711,GO:0015718,GO:0015849,GO:0015908,GO:0015909,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022834,GO:0022836,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0034220,GO:0044462,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039 - 0.00008031 55.0
HKD2_k127_4212092_4 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004847 518.0
HKD2_k127_4212092_40 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0003955 54.0
HKD2_k127_4212092_41 PFAM PKD domain containing protein - - - 0.0005618 54.0
HKD2_k127_4212092_5 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002498 473.0
HKD2_k127_4212092_6 Catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 458.0
HKD2_k127_4212092_7 PFAM NAD-dependent epimerase dehydratase K01710,K08678 - 4.1.1.35,4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005439 483.0
HKD2_k127_4212092_8 PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007824 380.0
HKD2_k127_4212092_9 Tryptophan halogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009391 376.0
HKD2_k127_4217249_0 Belongs to the ClpA ClpB family K03696 - - 1.393e-201 642.0
HKD2_k127_4217249_1 Elongation factor G, domain IV K02355 - - 2.454e-198 640.0
HKD2_k127_4217249_10 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000007169 252.0
HKD2_k127_4217249_11 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000008635 262.0
HKD2_k127_4217249_12 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000000000000000000000000000000000000000000003664 170.0
HKD2_k127_4217249_13 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.00000000000000000000000000000000000000003854 173.0
HKD2_k127_4217249_14 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000002097 141.0
HKD2_k127_4217249_15 Regulates arginine biosynthesis genes K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000009769 101.0
HKD2_k127_4217249_16 - - - - 0.000000000000000009174 87.0
HKD2_k127_4217249_17 outer membrane chaperone Skp (OmpH) K06142 - - 0.0000000001076 70.0
HKD2_k127_4217249_18 DNA-templated transcription, initiation K03088 - - 0.00008228 53.0
HKD2_k127_4217249_2 Belongs to the argininosuccinate synthase family. Type K01940 - 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007226 518.0
HKD2_k127_4217249_3 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002861 407.0
HKD2_k127_4217249_4 argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 387.0
HKD2_k127_4217249_5 Surface antigen variable number K07277 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006149 378.0
HKD2_k127_4217249_6 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 334.0
HKD2_k127_4217249_7 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 327.0
HKD2_k127_4217249_8 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001437 284.0
HKD2_k127_4217249_9 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000000001598 273.0
HKD2_k127_4305968_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009012 399.0
HKD2_k127_4305968_1 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002672 301.0
HKD2_k127_4305968_2 Stage II sporulation D domain protein K06381 - - 0.0000000000000000000000000000000000007087 149.0
HKD2_k127_4305968_3 - - - - 0.0000000000001304 83.0
HKD2_k127_4305968_4 Belongs to the peptidase S8 family - - - 0.00000006816 64.0
HKD2_k127_4396858_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009283 455.0
HKD2_k127_4396858_1 PFAM GCN5-related N-acetyltransferase - - - 0.000000001921 68.0
HKD2_k127_4411275_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 8.969e-308 981.0
HKD2_k127_4411275_1 Ribosomal protein S1 K02945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007349 592.0
HKD2_k127_4411275_10 ABC-type multidrug transport system, ATPase and permease K02021,K06147,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003173 417.0
HKD2_k127_4411275_11 dioxygenase K00457,K16421 - 1.13.11.27,1.13.11.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 386.0
HKD2_k127_4411275_12 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 393.0
HKD2_k127_4411275_13 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 368.0
HKD2_k127_4411275_14 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 370.0
HKD2_k127_4411275_15 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 365.0
HKD2_k127_4411275_16 Putative esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002485 323.0
HKD2_k127_4411275_17 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 327.0
HKD2_k127_4411275_18 ABC transporter K06861 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005752 306.0
HKD2_k127_4411275_19 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008658 321.0
HKD2_k127_4411275_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007223 594.0
HKD2_k127_4411275_20 Cobyrinic acid ac-diamide synthase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 286.0
HKD2_k127_4411275_21 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000446 298.0
HKD2_k127_4411275_22 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006204 276.0
HKD2_k127_4411275_23 Permease, YjgP YjgQ - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000169 293.0
HKD2_k127_4411275_24 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000008335 274.0
HKD2_k127_4411275_25 COG4974 Site-specific recombinase XerD K04763 GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - 0.0000000000000000000000000000000000000000000000000000000000000000000001374 266.0
HKD2_k127_4411275_26 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000003384 254.0
HKD2_k127_4411275_27 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000001635 241.0
HKD2_k127_4411275_28 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000003839 232.0
HKD2_k127_4411275_29 PFAM peptidase S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000007047 223.0
HKD2_k127_4411275_3 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004951 579.0
HKD2_k127_4411275_30 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000002176 204.0
HKD2_k127_4411275_31 chromosome segregation K03497 - - 0.0000000000000000000000000000000000000000000000000002182 196.0
HKD2_k127_4411275_32 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000001675 201.0
HKD2_k127_4411275_33 Peptidase family M50 K06402 - - 0.0000000000000000000000000000000000000000000000001005 184.0
HKD2_k127_4411275_34 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000000004198 198.0
HKD2_k127_4411275_35 Bifunctional nuclease K08999 - - 0.000000000000000000000000000000000000000000000105 173.0
HKD2_k127_4411275_36 PFAM histidine triad (HIT) protein K19710 - 2.7.7.53 0.000000000000000000000000000000000000000000001971 177.0
HKD2_k127_4411275_37 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0040007,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 0.000000000000000000000000000000000000000000002174 186.0
HKD2_k127_4411275_38 Methyltransferase type 11 K03892 - - 0.00000000000000000000000000000000000000002808 165.0
HKD2_k127_4411275_39 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000569 171.0
HKD2_k127_4411275_4 Putative Na+/H+ antiporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003433 572.0
HKD2_k127_4411275_40 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.00000000000000000000000000000000000001128 153.0
HKD2_k127_4411275_41 Belongs to the tRNA nucleotidyltransferase poly(A) polymerase family K00974 - 2.7.7.72 0.00000000000000000000000000000000006526 156.0
HKD2_k127_4411275_42 DinB family - - - 0.0000000000000000000000000000000001524 155.0
HKD2_k127_4411275_43 Mannose-6-phosphate isomerase - - - 0.000000000000000000000000000000598 141.0
HKD2_k127_4411275_44 Transglycosylase SLT domain - - - 0.0000000000000000000000000000008022 139.0
HKD2_k127_4411275_45 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.00000000000000000000000003766 122.0
HKD2_k127_4411275_46 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.00000000000000000000002263 114.0
HKD2_k127_4411275_47 phosphocarrier protein HPr K11189 - - 0.0000000000000000000008539 105.0
HKD2_k127_4411275_48 PTS system fructose IIA component K02793 - 2.7.1.191 0.000000000000000000005914 104.0
HKD2_k127_4411275_49 - - - - 0.00000001581 68.0
HKD2_k127_4411275_5 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000059 555.0
HKD2_k127_4411275_50 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.00000004647 66.0
HKD2_k127_4411275_51 PFAM Protein kinase K12132 - 2.7.11.1 0.0001162 50.0
HKD2_k127_4411275_6 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005316 557.0
HKD2_k127_4411275_7 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006019 489.0
HKD2_k127_4411275_8 homogentisate 12-dioxygenase K00451 - 1.13.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 413.0
HKD2_k127_4411275_9 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 417.0
HKD2_k127_4484859_0 Pyridoxal-phosphate dependent enzyme K01733 - 4.2.3.1 2.303e-217 692.0
HKD2_k127_4484859_1 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0000002661 64.0
HKD2_k127_4713354_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01585 - 4.1.1.19 9.314e-213 679.0
HKD2_k127_4713354_1 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006835 398.0
HKD2_k127_4713354_2 Mechanosensitive ion channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 304.0
HKD2_k127_4713354_3 Saccharopine dehydrogenase NADP binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006046 299.0
HKD2_k127_4713354_4 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000003319 161.0
HKD2_k127_4713354_5 pfam php K01104 - 3.1.3.48 0.000000000000000000000000001424 119.0
HKD2_k127_4713354_6 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000007996 118.0
HKD2_k127_4713354_7 DoxX family K16937 - 1.8.5.2 0.0000000000000004305 86.0
HKD2_k127_476396_0 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000599 608.0
HKD2_k127_476396_1 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001936 479.0
HKD2_k127_476396_2 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 433.0
HKD2_k127_476396_3 Domain of unknown function (DUF4178) - - - 0.000000000000000000000000000000000001432 149.0
HKD2_k127_476396_4 Protein of unknown function (DUF2490) - - - 0.0000000000000001418 83.0
HKD2_k127_476396_5 Domain of Unknown Function (DUF350) - - - 0.0000000005973 69.0
HKD2_k127_4858346_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 4.401e-274 872.0
HKD2_k127_4858346_1 Carboxyl transferase domain K01969 - 6.4.1.4 1.498e-249 779.0
HKD2_k127_4858346_10 Protein of unknown function (DUF1501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 302.0
HKD2_k127_4858346_11 PFAM phospholipid glycerol acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002275 304.0
HKD2_k127_4858346_12 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002071 296.0
HKD2_k127_4858346_13 PFAM Patatin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003996 276.0
HKD2_k127_4858346_14 Enoyl-CoA hydratase K13766 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000001294 245.0
HKD2_k127_4858346_15 Peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000001308 241.0
HKD2_k127_4858346_16 Competence protein ComEC K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000001996 248.0
HKD2_k127_4858346_17 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000005981 212.0
HKD2_k127_4858346_18 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.000000000000000000000000000000000000000000000000000000002949 212.0
HKD2_k127_4858346_19 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000000000001184 205.0
HKD2_k127_4858346_2 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 6.94e-239 751.0
HKD2_k127_4858346_20 NAD dependent epimerase/dehydratase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000008219 210.0
HKD2_k127_4858346_21 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000006565 185.0
HKD2_k127_4858346_22 methylmalonyl-CoA mutase C-terminal K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000002607 182.0
HKD2_k127_4858346_23 DinB family - - - 0.000000000000000000000000000000000000000003431 168.0
HKD2_k127_4858346_24 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.00000000000000000000000000000000000000001845 169.0
HKD2_k127_4858346_25 Glycosyl hydrolase family 3 N terminal domain K01207 - 3.2.1.52 0.0000000000000000000000000000000000000003304 174.0
HKD2_k127_4858346_26 AAA domain - - - 0.000000000000000000000000000000000000002152 167.0
HKD2_k127_4858346_27 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.00000000000000000000000000000000000001053 149.0
HKD2_k127_4858346_28 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000005842 165.0
HKD2_k127_4858346_29 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation K13598 - 2.7.13.3 0.0000000000000000000000000000000000004818 164.0
HKD2_k127_4858346_3 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 5.981e-209 679.0
HKD2_k127_4858346_30 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.0000000000000000000000000000000005291 141.0
HKD2_k127_4858346_31 Anion-transporting ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000009234 149.0
HKD2_k127_4858346_32 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K08744 - 2.7.8.41 0.0000000000000000000000000000002517 130.0
HKD2_k127_4858346_33 cheY-homologous receiver domain - - - 0.000000000000000000000000000002504 134.0
HKD2_k127_4858346_34 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.0000000000000000000000000000427 126.0
HKD2_k127_4858346_35 bacterial (prokaryotic) histone like domain K03530 - - 0.0000000000000000000000000132 112.0
HKD2_k127_4858346_37 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.0000000000000000004127 104.0
HKD2_k127_4858346_38 Tetratricopeptide repeat - - - 0.00000000000000003347 94.0
HKD2_k127_4858346_39 outer membrane autotransporter barrel domain protein - - - 0.0000000000000008503 87.0
HKD2_k127_4858346_4 Aromatic amino acid lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 508.0
HKD2_k127_4858346_40 Biotin carboxylase C-terminal domain K01968 - 6.4.1.4 0.000000000000001281 91.0
HKD2_k127_4858346_41 pilus organization K02674,K07004 - - 0.000000000000003902 90.0
HKD2_k127_4858346_42 helix_turn_helix, Lux Regulon - - - 0.00000000001561 74.0
HKD2_k127_4858346_43 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000001923 76.0
HKD2_k127_4858346_44 PFAM peptidase M22 glycoprotease K14742 - - 0.00000000007375 70.0
HKD2_k127_4858346_45 PHB/PHA accumulation regulator DNA-binding domain - - - 0.000000006891 64.0
HKD2_k127_4858346_46 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 0.000000171 63.0
HKD2_k127_4858346_47 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.0000005034 61.0
HKD2_k127_4858346_49 Protein of unknown function (DUF465) - - - 0.0003371 47.0
HKD2_k127_4858346_5 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 447.0
HKD2_k127_4858346_6 Beta-propeller repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004444 490.0
HKD2_k127_4858346_7 carboxylase K01965,K01968 - 6.4.1.3,6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006058 434.0
HKD2_k127_4858346_8 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003821 396.0
HKD2_k127_4858346_9 PFAM pyruvate carboxyltransferase K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000387 344.0
HKD2_k127_491662_0 ATPase activity K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001294 441.0
HKD2_k127_491662_1 sulfate ABC transporter K02046 - - 0.0000000000000000000009303 98.0
HKD2_k127_4961724_0 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 461.0
HKD2_k127_4961724_1 Alkane 1-monooxygenase K00496 - 1.14.15.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001589 337.0
HKD2_k127_4961724_2 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000423 320.0
HKD2_k127_4961724_3 von Willebrand factor (vWF) type A domain K07114 - - 0.000000000000000000000000000000001584 151.0
HKD2_k127_4961724_4 histone H2A K63-linked ubiquitination - - - 0.0000000000000000000000000003754 123.0
HKD2_k127_4961724_5 Tetratricopeptide repeat - - - 0.0000000000000006888 93.0
HKD2_k127_5154542_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 6.889e-284 896.0
HKD2_k127_5154542_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 3.017e-273 863.0
HKD2_k127_5154542_10 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000007775 211.0
HKD2_k127_5154542_11 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000006709 207.0
HKD2_k127_5154542_12 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000001205 181.0
HKD2_k127_5154542_13 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.000000000000000000000000000003574 138.0
HKD2_k127_5154542_14 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000005272 135.0
HKD2_k127_5154542_15 Protein of unknown function (DUF507) K09804 - - 0.000008581 51.0
HKD2_k127_5154542_16 TIGRFAM type IV pilus biogenesis stability protein PilW K02656 - - 0.0003805 51.0
HKD2_k127_5154542_2 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 589.0
HKD2_k127_5154542_3 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 451.0
HKD2_k127_5154542_4 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 414.0
HKD2_k127_5154542_5 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009434 363.0
HKD2_k127_5154542_6 stress-induced mitochondrial fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 332.0
HKD2_k127_5154542_7 Alanine-glyoxylate amino-transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001058 256.0
HKD2_k127_5154542_8 TIGRFAM DNA protecting protein DprA K04096 - - 0.00000000000000000000000000000000000000000000000000000000000000001024 238.0
HKD2_k127_5154542_9 tRNA 3'-trailer cleavage K00784,K01120 - 3.1.26.11,3.1.4.17 0.00000000000000000000000000000000000000000000000000000000000003356 223.0
HKD2_k127_5171248_0 aldehyde-lyase activity K01621 - 4.1.2.22,4.1.2.9 0.0 1351.0
HKD2_k127_5171248_1 Protein kinase domain K12132 - 2.7.11.1 1.642e-242 777.0
HKD2_k127_5171248_2 Protein kinase domain K12132 - 2.7.11.1 4.028e-231 744.0
HKD2_k127_5171248_3 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001849 355.0
HKD2_k127_5171248_4 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006177 299.0
HKD2_k127_5171248_5 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000009344 284.0
HKD2_k127_5171248_6 nitric oxide dioxygenase activity - - - 0.0000000000000000000004084 101.0
HKD2_k127_5171248_7 Tetratricopeptide repeat - - - 0.00001512 48.0
HKD2_k127_5177782_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1586.0
HKD2_k127_5177782_1 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 2.881e-229 721.0
HKD2_k127_5177782_10 Coenzyme A transferase K01028 - 2.8.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 331.0
HKD2_k127_5177782_11 Coenzyme A transferase K01029 - 2.8.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 326.0
HKD2_k127_5177782_12 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007314 318.0
HKD2_k127_5177782_13 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000004427 228.0
HKD2_k127_5177782_14 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000001166 226.0
HKD2_k127_5177782_15 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000008898 207.0
HKD2_k127_5177782_16 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0000000000000000000000000000000000000000000000000008924 209.0
HKD2_k127_5177782_17 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000007971 165.0
HKD2_k127_5177782_18 - - - - 0.000000000000000000000000000000000002609 155.0
HKD2_k127_5177782_19 Responsible for synthesis of pseudouridine from uracil K06179,K06180 - 5.4.99.23,5.4.99.24 0.00000000000000000000000000000000005176 141.0
HKD2_k127_5177782_2 phosphoribosylamine-glycine ligase activity K01919 - 6.3.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006833 548.0
HKD2_k127_5177782_20 Multidrug ABC transporter permease - - - 0.000000000000000000000000000001307 138.0
HKD2_k127_5177782_21 Histidine kinase K02668,K07708 - 2.7.13.3 0.000000000000000000000000000004487 139.0
HKD2_k127_5177782_22 peptidase U62, modulator of DNA gyrase K03568 - - 0.0000000000000000000000000004098 129.0
HKD2_k127_5177782_23 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000000000009727 124.0
HKD2_k127_5177782_24 Prokaryotic N-terminal methylation motif K02456 - - 0.000000000000000000000008548 107.0
HKD2_k127_5177782_25 Bacterial membrane protein YfhO - - - 0.00000000000000000000001319 117.0
HKD2_k127_5177782_26 DSBA-like thioredoxin domain - - - 0.00000000000000003658 94.0
HKD2_k127_5177782_27 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00000000000000009818 95.0
HKD2_k127_5177782_28 Neisseria PilC beta-propeller domain K02674 - - 0.0000000000000005988 94.0
HKD2_k127_5177782_29 Biotin-requiring enzyme - - - 0.000000000000001162 90.0
HKD2_k127_5177782_3 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 526.0
HKD2_k127_5177782_30 Integral membrane protein DUF92 - - - 0.00000000000005143 87.0
HKD2_k127_5177782_31 serine threonine protein kinase K12132 - 2.7.11.1 0.000000001189 72.0
HKD2_k127_5177782_32 Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.000000005758 69.0
HKD2_k127_5177782_33 Tetratricopeptide repeat - - - 0.00000007917 65.0
HKD2_k127_5177782_34 Type II secretion system (T2SS), protein G K02456 - - 0.00000562 55.0
HKD2_k127_5177782_35 domain, Protein - - - 0.000005631 55.0
HKD2_k127_5177782_36 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0009195 52.0
HKD2_k127_5177782_4 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005025 482.0
HKD2_k127_5177782_5 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 434.0
HKD2_k127_5177782_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001058 388.0
HKD2_k127_5177782_7 Bacterial regulatory protein, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 376.0
HKD2_k127_5177782_8 PFAM type II secretion system protein E K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 381.0
HKD2_k127_5177782_9 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 356.0
HKD2_k127_5185355_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.784e-215 681.0
HKD2_k127_5185355_1 mRNA catabolic process K18682 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000434 526.0
HKD2_k127_5185355_10 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000000000000000000001253 177.0
HKD2_k127_5185355_11 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000000000000000000000000001976 144.0
HKD2_k127_5185355_12 O-antigen ligase like membrane protein - - - 0.0000000000000000000000001229 121.0
HKD2_k127_5185355_13 Protein of unknown function, DUF481 K07283 - - 0.0000000000000002987 92.0
HKD2_k127_5185355_14 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.00000000000001355 83.0
HKD2_k127_5185355_15 Cell division protein ZapA K09888 - - 0.000000000001602 72.0
HKD2_k127_5185355_16 Exonuclease VII small subunit - - - 0.000000000005627 69.0
HKD2_k127_5185355_17 Belongs to the UPF0434 family K09791 - - 0.00000002929 58.0
HKD2_k127_5185355_3 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 377.0
HKD2_k127_5185355_4 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 340.0
HKD2_k127_5185355_5 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 308.0
HKD2_k127_5185355_6 YmdB-like protein K09769 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001036 286.0
HKD2_k127_5185355_7 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000003541 252.0
HKD2_k127_5185355_9 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000000001077 189.0
HKD2_k127_5242129_0 Nucleotidyl transferase K00973 - 2.7.7.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 421.0
HKD2_k127_5242129_1 NAD dependent epimerase/dehydratase family K05281 - 1.3.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005281 419.0
HKD2_k127_5242129_2 ATP ADP translocase K03301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 368.0
HKD2_k127_5242129_3 Domain of unknown function (DUF4301) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006408 356.0
HKD2_k127_5242129_4 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000007455 213.0
HKD2_k127_5242129_5 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000002924 214.0
HKD2_k127_5242129_6 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000001855 208.0
HKD2_k127_5242129_7 (twin-arginine translocation) pathway signal - - - 0.000000000000000000000000000000009822 135.0
HKD2_k127_5242129_8 phosphoserine phosphatase activity K07052,K07315 - 3.1.3.3 0.000000000000000000000000000009587 137.0
HKD2_k127_5270321_0 Tetratricopeptide repeat - - - 0.00000000000000000000004179 113.0
HKD2_k127_527938_0 serine-type peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 504.0
HKD2_k127_527938_1 haloacid dehalogenase-like hydrolase K01838 - 5.4.2.6 0.0000005619 53.0
HKD2_k127_531666_0 Pfam Sulfatase K01130 - 3.1.6.1 0.0 1560.0
HKD2_k127_531666_1 Protein of unknown function (DUF1214) - - - 6.967e-295 910.0
HKD2_k127_531666_10 - - - - 0.0000000000000000000000000000000000000000000004152 176.0
HKD2_k127_531666_11 - - - - 0.0000000000000000000000000000000004456 141.0
HKD2_k127_531666_12 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000002894 112.0
HKD2_k127_531666_14 Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000002315 86.0
HKD2_k127_531666_15 - - - - 0.000000000000001957 81.0
HKD2_k127_531666_16 - - - - 0.000000000001523 77.0
HKD2_k127_531666_2 Protein of unknown function (DUF1254) - - - 1.791e-236 741.0
HKD2_k127_531666_3 PFAM response regulator receiver K07713 - - 8.965e-198 630.0
HKD2_k127_531666_4 TonB-dependent Receptor Plug Domain K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003393 594.0
HKD2_k127_531666_5 HAMP domain K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000551 480.0
HKD2_k127_531666_6 Polyphosphate kinase 2 (PPK2) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008658 426.0
HKD2_k127_531666_7 Predicted periplasmic protein (DUF2092) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002517 267.0
HKD2_k127_531666_8 Surface antigen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001047 254.0
HKD2_k127_531666_9 Peptidase family M54 K06974 - - 0.00000000000000000000000000000000000000000000000001951 185.0
HKD2_k127_5404035_0 Belongs to the carbamoyltransferase HypF family K04656 - - 9.327e-256 809.0
HKD2_k127_5404035_1 iron-nicotianamine transmembrane transporter activity - - - 3.952e-217 693.0
HKD2_k127_5404035_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005183 565.0
HKD2_k127_5404035_3 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006245 527.0
HKD2_k127_5404035_4 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 465.0
HKD2_k127_5404035_5 AIR synthase related protein, C-terminal domain K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 427.0
HKD2_k127_5404035_6 major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000001308 188.0
HKD2_k127_5404035_7 FAD dependent oxidoreductase K15736 - - 0.000000000000000000000000000000000001482 161.0
HKD2_k127_5404035_8 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.0000000000000000000002297 99.0
HKD2_k127_5404035_9 Protein of unknown function (DUF2911) - - - 0.000000009908 63.0
HKD2_k127_5468653_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07788 - - 0.0 1347.0
HKD2_k127_5468653_1 Ferrous iron transport protein B K04759 - - 3.27e-262 826.0
HKD2_k127_5468653_10 transferase activity, transferring glycosyl groups K20534 - - 0.00000000000000000000000000000000000108 157.0
HKD2_k127_5468653_11 Protein of unknown function (DUF2911) - - - 0.0000000000000000000000000000000001097 147.0
HKD2_k127_5468653_12 FeoA K04758 - - 0.00000000000000000001957 102.0
HKD2_k127_5468653_13 Bacterial regulatory proteins, tetR family - - - 0.000000000000001323 84.0
HKD2_k127_5468653_14 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000009542 76.0
HKD2_k127_5468653_2 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 484.0
HKD2_k127_5468653_3 Biotin-lipoyl like K07799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 339.0
HKD2_k127_5468653_4 CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000629 286.0
HKD2_k127_5468653_5 Belongs to the HpcH HpaI aldolase family K01644,K14451,K18292 - 3.1.2.30,4.1.3.25,4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000001306 274.0
HKD2_k127_5468653_6 NAD dependent epimerase dehydratase K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000005347 220.0
HKD2_k127_5468653_7 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000811 216.0
HKD2_k127_5468653_8 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000003515 208.0
HKD2_k127_5468653_9 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000001203 189.0
HKD2_k127_5499118_0 Large extracellular alpha-helical protein - - - 0.0 1073.0
HKD2_k127_5499118_1 PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005779 559.0
HKD2_k127_5499118_10 form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription K12410 - - 0.0000000000000000000000000000000000000000000000000000000000003473 243.0
HKD2_k127_5499118_11 TatD related DNase K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.000000000000000000000000000000000000000000000000000000000519 213.0
HKD2_k127_5499118_12 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000007287 173.0
HKD2_k127_5499118_13 oxidation-reduction process K09022 - 3.5.99.10 0.000000000000000000000000000000000000001653 150.0
HKD2_k127_5499118_14 FR47-like protein - - - 0.000000000000000000000000000000000000002185 166.0
HKD2_k127_5499118_15 PFAM PIN domain - - - 0.0000000000000000000000000000004289 130.0
HKD2_k127_5499118_16 - - - - 0.0000000000000000000000000000183 130.0
HKD2_k127_5499118_17 osmosensitive K channel K07646 - 2.7.13.3 0.0000000000000000000004072 111.0
HKD2_k127_5499118_18 Zincin-like metallopeptidase - - - 0.00000000000000000000348 104.0
HKD2_k127_5499118_19 Lysin motif - - - 0.000000000000000004308 95.0
HKD2_k127_5499118_2 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 528.0
HKD2_k127_5499118_20 CHASE - - - 0.000000000000003872 91.0
HKD2_k127_5499118_21 positive regulation of growth - - - 0.0000000000162 69.0
HKD2_k127_5499118_22 Protein of unknown function (DUF3592) - - - 0.0002533 49.0
HKD2_k127_5499118_3 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 396.0
HKD2_k127_5499118_4 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003255 380.0
HKD2_k127_5499118_5 Zinc-binding dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007275 366.0
HKD2_k127_5499118_6 PFAM Cys Met metabolism K01739,K01760,K01761 - 2.5.1.48,4.4.1.11,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004863 318.0
HKD2_k127_5499118_7 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009122 291.0
HKD2_k127_5499118_8 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000005121 276.0
HKD2_k127_5499118_9 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide K08641 - 3.4.13.22 0.0000000000000000000000000000000000000000000000000000000000000000001954 244.0
HKD2_k127_5609273_0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 2.987e-223 708.0
HKD2_k127_5609273_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 563.0
HKD2_k127_5609273_10 Periplasmic binding protein - - - 0.000000000000000000000000000000000000000007731 169.0
HKD2_k127_5609273_11 DNA polymerase K02347 - - 0.0000000000000000000000001251 109.0
HKD2_k127_5609273_12 Protein of unknown function (DUF2089) - - - 0.00000000000000000001024 94.0
HKD2_k127_5609273_13 phosphodiesterase K01113 - 3.1.3.1 0.00000000001774 77.0
HKD2_k127_5609273_14 - - - - 0.000000001553 68.0
HKD2_k127_5609273_15 chlorophyll binding - - - 0.00000001203 68.0
HKD2_k127_5609273_16 recA bacterial DNA recombination protein - - - 0.00001624 57.0
HKD2_k127_5609273_2 Pyruvate ferredoxin oxidoreductase beta subunit C terminal K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004503 458.0
HKD2_k127_5609273_3 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 401.0
HKD2_k127_5609273_4 Belongs to the pyruvate kinase family K00873 GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007942 323.0
HKD2_k127_5609273_5 electron transfer flavoprotein, alpha subunit K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 293.0
HKD2_k127_5609273_6 Electron transfer flavoprotein domain K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000001503 230.0
HKD2_k127_5609273_7 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K14161 - - 0.0000000000000000000000000000000000000000000000000000001134 215.0
HKD2_k127_5609273_8 Glyoxalase bleomycin resistance protein dioxygenase K04750 - - 0.0000000000000000000000000000000000000000000000000000003498 198.0
HKD2_k127_5609273_9 GTP cyclohydrolase K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000001567 183.0
HKD2_k127_5615030_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 576.0
HKD2_k127_5615030_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002036 233.0
HKD2_k127_5615030_2 Acetyl-CoA carboxylase, biotin carboxyl carrier protein K01571,K01960 - 4.1.1.3,6.4.1.1 0.000000000000000000000000000002231 139.0
HKD2_k127_5615030_3 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.0000000000000000000000000007599 121.0
HKD2_k127_5615030_4 Secretin and TonB N terminus short domain K02666 - - 0.0000000000000000000008144 98.0
HKD2_k127_5615030_5 Tetratricopeptide repeat K00661,K18626 - 2.3.1.79 0.00000000002684 76.0
HKD2_k127_5615030_6 PKD domain containing protein K01179 - 3.2.1.4 0.00000003373 67.0
HKD2_k127_5615030_7 Polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 - - - 0.000527 53.0
HKD2_k127_56397_0 Tetratricopeptide repeats K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006991 464.0
HKD2_k127_56397_1 PHP domain protein K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009697 359.0
HKD2_k127_56397_2 PAP2 superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000205 352.0
HKD2_k127_56397_3 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000002977 221.0
HKD2_k127_56397_4 - - - - 0.00000000000000000000000000003821 133.0
HKD2_k127_56397_5 COG0784 FOG CheY-like receiver K02658 - - 0.000000000000000000000000005161 114.0
HKD2_k127_56397_6 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000003917 111.0
HKD2_k127_56397_7 PFAM Transcriptional - - - 0.00000000000001548 82.0
HKD2_k127_56397_9 - - - - 0.0002281 47.0
HKD2_k127_5658112_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0 1189.0
HKD2_k127_5658112_1 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002883 566.0
HKD2_k127_5658112_10 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001341 263.0
HKD2_k127_5658112_11 Phage integrase, N-terminal SAM-like domain K03733,K04763 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000009391 256.0
HKD2_k127_5658112_12 Secondary thiamine-phosphate synthase enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000006067 236.0
HKD2_k127_5658112_13 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000007957 246.0
HKD2_k127_5658112_14 Protein of unknown function (DUF4197) - - - 0.000000000000000000000000000000000000000000000000000000000000000002855 236.0
HKD2_k127_5658112_15 Gamma-glutamyl-gamma-aminobutyrate hydrolase K07010 - - 0.000000000000000000000000000000000000000000000000000000000000000002911 234.0
HKD2_k127_5658112_16 Proteasome subunit K01419 - 3.4.25.2 0.00000000000000000000000000000000000000000000000000000000000000001507 228.0
HKD2_k127_5658112_17 Pfam:DUF59 - - - 0.00000000000000000000000000000000000000000000000000002542 209.0
HKD2_k127_5658112_18 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000004962 213.0
HKD2_k127_5658112_19 PFAM Phenazine biosynthesis PhzC PhzF protein K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000008839 192.0
HKD2_k127_5658112_2 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 496.0
HKD2_k127_5658112_20 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000002828 170.0
HKD2_k127_5658112_21 PFAM Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000000000000000006607 161.0
HKD2_k127_5658112_22 Belongs to the Fur family K03711 - - 0.0000000000000000000000000000000001285 138.0
HKD2_k127_5658112_23 membrane K08972 - - 0.000000000000000000000000001752 120.0
HKD2_k127_5658112_24 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000003594 123.0
HKD2_k127_5658112_25 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000007702 108.0
HKD2_k127_5658112_27 Subtilase family - - - 0.0000000000000002297 94.0
HKD2_k127_5658112_28 Uncharacterized conserved protein (DUF2203) - - - 0.0000000000000003564 93.0
HKD2_k127_5658112_29 Protein of unknown function (DUF1573) - - - 0.00000000000000041 90.0
HKD2_k127_5658112_3 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003094 452.0
HKD2_k127_5658112_30 Fibronectin, type III domain - - - 0.000000000000001085 92.0
HKD2_k127_5658112_31 Bacterial regulatory proteins, tetR family - - - 0.0000000000000383 80.0
HKD2_k127_5658112_32 ubiE/COQ5 methyltransferase family - - - 0.00000000000222 82.0
HKD2_k127_5658112_33 amine dehydrogenase activity - - - 0.000000000004947 79.0
HKD2_k127_5658112_34 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000006155 70.0
HKD2_k127_5658112_35 nuclear chromosome segregation - - - 0.00000000001565 73.0
HKD2_k127_5658112_4 Mur ligase family, catalytic domain K02558 - 6.3.2.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005281 390.0
HKD2_k127_5658112_5 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001828 389.0
HKD2_k127_5658112_6 DNA photolyase K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 371.0
HKD2_k127_5658112_7 Peptidase, M20 K01436 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007178 327.0
HKD2_k127_5658112_8 NeuB family K03856,K04518,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 316.0
HKD2_k127_5658112_9 of the major facilitator superfamily K08151 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006987 276.0
HKD2_k127_5703770_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 7.381e-214 675.0
HKD2_k127_5703770_1 TIGRFAM hydrolase, TatD family K03424 - - 0.000000000000001327 79.0
HKD2_k127_5735091_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 494.0
HKD2_k127_5735091_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000312 270.0
HKD2_k127_5735091_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000003367 119.0
HKD2_k127_5736240_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002639 497.0
HKD2_k127_5736240_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006824 357.0
HKD2_k127_5736240_2 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000000000000000000162 106.0
HKD2_k127_5865295_0 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01885,K01894 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007801 302.0
HKD2_k127_5865295_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000116 82.0
HKD2_k127_5865295_3 Dihaem cytochrome c - - - 0.0002602 51.0
HKD2_k127_5905982_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1082.0
HKD2_k127_5905982_1 3-isopropylmalate dehydratase activity K01703 - 4.2.1.33,4.2.1.35 1.833e-216 678.0
HKD2_k127_5905982_10 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 385.0
HKD2_k127_5905982_11 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 386.0
HKD2_k127_5905982_12 HMGL-like K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 373.0
HKD2_k127_5905982_13 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 318.0
HKD2_k127_5905982_14 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000001036 237.0
HKD2_k127_5905982_15 3-isopropylmalate dehydratase activity K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000001611 213.0
HKD2_k127_5905982_16 Memo-like protein K06990 - - 0.0000000000000000000000000000000000000000000000000000003674 214.0
HKD2_k127_5905982_17 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000002947 217.0
HKD2_k127_5905982_18 Methyltransferase domain - - - 0.000000000000000000000000000000000000001478 159.0
HKD2_k127_5905982_19 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000001693 166.0
HKD2_k127_5905982_2 AMP-binding enzyme K01897 - 6.2.1.3 1.729e-200 662.0
HKD2_k127_5905982_20 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000005586 132.0
HKD2_k127_5905982_21 - - - - 0.00000000000000000000003981 114.0
HKD2_k127_5905982_22 Bacterial membrane protein YfhO - - - 0.00000000000000000002099 108.0
HKD2_k127_5905982_23 AsmA-like C-terminal region - - - 0.000000000000000003428 101.0
HKD2_k127_5905982_24 Response regulator receiver domain - - - 0.0000000000001487 84.0
HKD2_k127_5905982_25 Domain of unknown function (DUF4430) - - - 0.00000000156 69.0
HKD2_k127_5905982_26 Diguanylate cyclase - - - 0.0002964 44.0
HKD2_k127_5905982_3 AMP-binding enzyme K01897 - 6.2.1.3 1.495e-195 660.0
HKD2_k127_5905982_4 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 616.0
HKD2_k127_5905982_5 Isocitrate/isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003117 589.0
HKD2_k127_5905982_6 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K03918 - 2.6.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 514.0
HKD2_k127_5905982_7 Transport of potassium into the cell K03549 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 527.0
HKD2_k127_5905982_8 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 508.0
HKD2_k127_5905982_9 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000847 439.0
HKD2_k127_6025502_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 8.429e-239 770.0
HKD2_k127_6025502_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K11177 - 1.17.1.4 3.406e-196 638.0
HKD2_k127_6025502_10 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000006136 198.0
HKD2_k127_6025502_11 2Fe-2S -binding K13483 - - 0.000000000000000000000000000000000000000000000002041 180.0
HKD2_k127_6025502_12 CDP-alcohol phosphatidyltransferase K00995 - 2.7.8.5 0.000000000000000000000000000000000000000000000006166 179.0
HKD2_k127_6025502_13 XdhC Rossmann domain - - - 0.0000000000000000000000000000000000000000000003506 177.0
HKD2_k127_6025502_14 Methionine biosynthesis protein MetW K18827 - 2.1.1.294,2.7.1.181 0.000000000000000000000000000000000000000000001666 182.0
HKD2_k127_6025502_15 permease - - - 0.00000000000000000000000000000000000000000002001 179.0
HKD2_k127_6025502_16 3-demethylubiquinone-9 3-O-methyltransferase activity K18827 - 2.1.1.294,2.7.1.181 0.000000000000000000000000000000000000006826 169.0
HKD2_k127_6025502_17 catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.00000000000000000000000000000000000004448 154.0
HKD2_k127_6025502_18 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000005567 156.0
HKD2_k127_6025502_19 protein-disulfide reductase activity K05807 - - 0.000000000000000000000006536 110.0
HKD2_k127_6025502_2 Type II/IV secretion system protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006771 533.0
HKD2_k127_6025502_20 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.00000000000000000000006831 109.0
HKD2_k127_6025502_21 Haloacid dehalogenase-like hydrolase K07025,K20866 - 3.1.3.10 0.0000000000000000000002233 104.0
HKD2_k127_6025502_22 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000003191 106.0
HKD2_k127_6025502_23 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.000000000000000007836 99.0
HKD2_k127_6025502_24 Molybdopterin K07141 - 2.7.7.76 0.0000000000000006393 85.0
HKD2_k127_6025502_25 Domain of unknown function (DUF309) K09763 - - 0.000000000002391 71.0
HKD2_k127_6025502_26 Rieske [2Fe-2S] domain - - - 0.00000000009189 76.0
HKD2_k127_6025502_27 Mitochondrial biogenesis AIM24 - - - 0.000000001108 70.0
HKD2_k127_6025502_28 - - - - 0.00000001814 66.0
HKD2_k127_6025502_29 Modulates RecA activity K03565 - - 0.000001122 57.0
HKD2_k127_6025502_3 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004635 422.0
HKD2_k127_6025502_4 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005362 419.0
HKD2_k127_6025502_5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007931 365.0
HKD2_k127_6025502_6 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 320.0
HKD2_k127_6025502_7 Phosphoglucomutase/phosphomannomutase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 329.0
HKD2_k127_6025502_8 CO dehydrogenase flavoprotein C-terminal domain K11178 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000003735 276.0
HKD2_k127_6025502_9 Transporter associated domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000001037 245.0
HKD2_k127_6041220_0 Sortilin, neurotensin receptor 3, - - - 0.0 1128.0
HKD2_k127_6041220_1 PFAM BNR Asp-box repeat - - - 1.676e-241 771.0
HKD2_k127_6041220_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008671 316.0
HKD2_k127_6041220_11 major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001904 295.0
HKD2_k127_6041220_12 TIGRFAM 2-oxoacid acceptor oxidoreductase, beta subunit, pyruvate 2-ketoisovalerate family K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000002754 292.0
HKD2_k127_6041220_13 Transport and Golgi organisation 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002746 263.0
HKD2_k127_6041220_14 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000005697 256.0
HKD2_k127_6041220_15 tryptophan K00500 GO:0000003,GO:0001505,GO:0003008,GO:0003674,GO:0003824,GO:0004497,GO:0004505,GO:0004510,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006464,GO:0006520,GO:0006558,GO:0006559,GO:0006568,GO:0006569,GO:0006570,GO:0006571,GO:0006576,GO:0006582,GO:0006584,GO:0006586,GO:0006725,GO:0006726,GO:0006732,GO:0006807,GO:0006950,GO:0006979,GO:0007275,GO:0007568,GO:0007610,GO:0007611,GO:0007613,GO:0007616,GO:0008150,GO:0008152,GO:0008340,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009073,GO:0009074,GO:0009095,GO:0009308,GO:0009310,GO:0009712,GO:0009713,GO:0009987,GO:0010259,GO:0016053,GO:0016054,GO:0016491,GO:0016597,GO:0016705,GO:0016714,GO:0017144,GO:0018126,GO:0018958,GO:0019438,GO:0019439,GO:0019538,GO:0019748,GO:0019751,GO:0019752,GO:0031406,GO:0032501,GO:0032502,GO:0034311,GO:0034641,GO:0036094,GO:0036211,GO:0040002,GO:0042133,GO:0042136,GO:0042335,GO:0042402,GO:0042423,GO:0042430,GO:0042436,GO:0042438,GO:0042440,GO:0042441,GO:0042558,GO:0042737,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043324,GO:0043412,GO:0043436,GO:0043473,GO:0043474,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0046146,GO:0046148,GO:0046189,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0046983,GO:0048037,GO:0048066,GO:0048069,GO:0048856,GO:0050877,GO:0050890,GO:0050896,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901615,GO:1901617,GO:1902221,GO:1902222 1.14.16.1 0.000000000000000000000000000000000000000000000000000000000003857 235.0
HKD2_k127_6041220_16 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000000002215 233.0
HKD2_k127_6041220_17 TIGRFAM diguanylate cyclase K02488 - 2.7.7.65 0.0000000000000000000000000000000000004021 156.0
HKD2_k127_6041220_19 von Willebrand factor, type A - - - 0.00000000002477 76.0
HKD2_k127_6041220_2 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679,K01744 - 4.2.1.2,4.3.1.1 4.11e-205 647.0
HKD2_k127_6041220_20 von willebrand factor, type A K07114 - - 0.000001237 61.0
HKD2_k127_6041220_21 metallopeptidase activity - - - 0.00000448 58.0
HKD2_k127_6041220_3 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 531.0
HKD2_k127_6041220_4 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 537.0
HKD2_k127_6041220_5 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008428 468.0
HKD2_k127_6041220_6 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003767 404.0
HKD2_k127_6041220_7 Protein kinase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001186 403.0
HKD2_k127_6041220_8 PFAM peptidase S1 and S6 chymotrypsin Hap - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002806 389.0
HKD2_k127_6041220_9 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007026 384.0
HKD2_k127_6311707_0 Fumarase C-terminus K01676 - 4.2.1.2 2.122e-254 794.0
HKD2_k127_6311707_1 Involved in the tonB-independent uptake of proteins - - - 2.502e-206 670.0
HKD2_k127_6311707_10 serine-type peptidase activity K01990,K08884,K12132,K18912 - 1.14.99.50,2.7.11.1 0.0000000000000000000000005046 109.0
HKD2_k127_6311707_11 PFAM AhpC TSA family K03564 - 1.11.1.15 0.000000000000000003509 87.0
HKD2_k127_6311707_12 peptidase inhibitor activity - - - 0.00000000000000001723 96.0
HKD2_k127_6311707_13 lyase activity - - - 0.000000000000003656 85.0
HKD2_k127_6311707_14 PFAM AhpC TSA family K03564 - 1.11.1.15 0.000000000000008782 74.0
HKD2_k127_6311707_15 polysaccharide deacetylase K15531 - 3.2.1.156 0.00000000000003198 87.0
HKD2_k127_6311707_16 Protein tyrosine kinase K08884,K12132 - 2.7.11.1 0.00000000000024 84.0
HKD2_k127_6311707_19 Bacteriophage replication gene A protein (GPA) - - - 0.0000000001173 63.0
HKD2_k127_6311707_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005021 546.0
HKD2_k127_6311707_20 cell cycle K05589,K13052 - - 0.0005507 48.0
HKD2_k127_6311707_21 - - - - 0.0007884 53.0
HKD2_k127_6311707_22 Ankyrin repeat K06867 - - 0.0007884 53.0
HKD2_k127_6311707_3 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 458.0
HKD2_k127_6311707_4 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007637 464.0
HKD2_k127_6311707_5 Beta-lactamase K17836 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 410.0
HKD2_k127_6311707_6 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008218 396.0
HKD2_k127_6311707_7 PFAM TPR repeat-containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007366 342.0
HKD2_k127_6311707_8 Domain of Unknown function (DUF542) K07322 - - 0.000000000000000000000000000000000000000000000000002277 210.0
HKD2_k127_6311707_9 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000000000000000009827 160.0
HKD2_k127_6440378_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005387 571.0
HKD2_k127_6440378_1 Proton-conducting membrane transporter K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000579 461.0
HKD2_k127_6440378_10 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.0000000000000000006369 101.0
HKD2_k127_6440378_2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 462.0
HKD2_k127_6440378_3 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000222 384.0
HKD2_k127_6440378_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 341.0
HKD2_k127_6440378_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000005582 234.0
HKD2_k127_6440378_6 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000106 166.0
HKD2_k127_6440378_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000001107 153.0
HKD2_k127_6440378_8 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000000009088 129.0
HKD2_k127_6440378_9 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000001219 111.0
HKD2_k127_6443403_0 Ftsk_gamma K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007554 572.0
HKD2_k127_6443403_1 O-acetylhomoserine K01740 - 2.5.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 504.0
HKD2_k127_6443403_10 PFAM Rhomboid family protein - - - 0.0000000000000000000000000000000000000000000000000000000000005257 218.0
HKD2_k127_6443403_11 Major facilitator Superfamily K06902 - - 0.00000000000000000000000000000000000000000000000000000004719 213.0
HKD2_k127_6443403_12 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000008447 201.0
HKD2_k127_6443403_13 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000005736 177.0
HKD2_k127_6443403_14 Bacitracin resistance protein BacA K06153 - 3.6.1.27 0.00000000000000000000000000000000000002038 154.0
HKD2_k127_6443403_15 von Willebrand factor (vWF) type A domain K07114 - - 0.000000000000000000000000000000000000677 162.0
HKD2_k127_6443403_16 belongs to the thioredoxin family K03671 GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - 0.000000000000000000000000000000000002957 141.0
HKD2_k127_6443403_17 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000004064 140.0
HKD2_k127_6443403_18 GAF domain - - - 0.00000000000000000000000000000000002431 157.0
HKD2_k127_6443403_19 regulation of translation K03530 - - 0.000000000000000000000000000000001029 132.0
HKD2_k127_6443403_2 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009862 430.0
HKD2_k127_6443403_20 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000008186 93.0
HKD2_k127_6443403_21 Oxygen tolerance - - - 0.00000000000000000009206 105.0
HKD2_k127_6443403_22 Protein of unknown function (DUF4230) - - - 0.0000000003212 72.0
HKD2_k127_6443403_23 Psort location CytoplasmicMembrane, score - - - 0.000006875 59.0
HKD2_k127_6443403_3 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 412.0
HKD2_k127_6443403_4 PFAM ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005394 402.0
HKD2_k127_6443403_5 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003831 304.0
HKD2_k127_6443403_6 Homoserine dehydrogenase K00003 - 1.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001309 288.0
HKD2_k127_6443403_7 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000004636 254.0
HKD2_k127_6443403_8 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.000000000000000000000000000000000000000000000000000000000000000000075 256.0
HKD2_k127_6443403_9 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000001104 233.0
HKD2_k127_6595066_0 Glycosyl hydrolase 36 superfamily, catalytic domain K00702,K13688 - 2.4.1.20 0.0 3339.0
HKD2_k127_6595066_1 AcrB/AcrD/AcrF family K03296 - - 0.0 1632.0
HKD2_k127_6595066_10 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000912 406.0
HKD2_k127_6595066_11 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 400.0
HKD2_k127_6595066_12 PAS fold K02484 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 390.0
HKD2_k127_6595066_13 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 380.0
HKD2_k127_6595066_14 OST-HTH/LOTUS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007051 351.0
HKD2_k127_6595066_15 Sodium/calcium exchanger protein K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005065 342.0
HKD2_k127_6595066_16 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 345.0
HKD2_k127_6595066_17 domain, Protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007361 348.0
HKD2_k127_6595066_18 formate dehydrogenase K00124 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 324.0
HKD2_k127_6595066_19 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000264 336.0
HKD2_k127_6595066_2 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 4.558e-302 947.0
HKD2_k127_6595066_20 translation initiation factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 306.0
HKD2_k127_6595066_21 formate dehydrogenase (NAD+) activity K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000601 310.0
HKD2_k127_6595066_22 PFAM aminotransferase, class I K00812,K10907 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000163 282.0
HKD2_k127_6595066_23 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K07713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002931 287.0
HKD2_k127_6595066_24 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002485 269.0
HKD2_k127_6595066_25 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000135 246.0
HKD2_k127_6595066_26 Transglutaminase/protease-like homologues - - - 0.000000000000000000000000000000000000000000000000000000000000000000001295 256.0
HKD2_k127_6595066_27 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000004073 245.0
HKD2_k127_6595066_28 TonB-dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000001107 251.0
HKD2_k127_6595066_29 hemerythrin HHE cation binding domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000001681 222.0
HKD2_k127_6595066_3 phosphoenolpyruvate carboxykinase (ATP) activity K01610 GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 2.627e-236 762.0
HKD2_k127_6595066_30 short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000002625 224.0
HKD2_k127_6595066_31 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000006677 222.0
HKD2_k127_6595066_32 Redoxin K03564 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000001721 201.0
HKD2_k127_6595066_33 TIGRFAM Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000000001258 211.0
HKD2_k127_6595066_34 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000003536 195.0
HKD2_k127_6595066_35 regulation of DNA-templated transcription, elongation - - - 0.0000000000000000000000000000000000000000000000000001735 201.0
HKD2_k127_6595066_36 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase K03772 - 5.2.1.8 0.00000000000000000000000000000000000000000000000004207 187.0
HKD2_k127_6595066_37 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.000000000000000000000000000000000000000000000008315 184.0
HKD2_k127_6595066_38 wide pore channel activity K07267 - - 0.00000000000000000000000000000000000000000000007056 192.0
HKD2_k127_6595066_39 TIGRFAM polysaccharide deactylase family protein, PEP-CTERM locus subfamily - - - 0.000000000000000000000000000000000000000000006399 181.0
HKD2_k127_6595066_4 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 3.431e-235 771.0
HKD2_k127_6595066_40 NUDIX domain K01515 - 3.6.1.13 0.00000000000000000000000000000000000000000002459 185.0
HKD2_k127_6595066_41 prohibitin homologues - - - 0.0000000000000000000000000000000000000000001656 175.0
HKD2_k127_6595066_42 Belongs to the GcvT family K06980 - - 0.000000000000000000000000000000000000000001203 178.0
HKD2_k127_6595066_43 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000001408 157.0
HKD2_k127_6595066_44 AMMECR1 K09141 - - 0.00000000000000000000000000000000000000227 162.0
HKD2_k127_6595066_45 Cytochrome c - - - 0.000000000000000000000000000000000000003832 162.0
HKD2_k127_6595066_46 formate dehydrogenase K00127,K08350 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009326,GO:0009987,GO:0015942,GO:0015944,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0020037,GO:0022900,GO:0031224,GO:0031226,GO:0032787,GO:0032991,GO:0033554,GO:0036397,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0051716,GO:0052738,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1902494 - 0.00000000000000000000000000000000000004504 153.0
HKD2_k127_6595066_47 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000002298 156.0
HKD2_k127_6595066_48 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000000000000000001034 154.0
HKD2_k127_6595066_49 hydrolase of the alpha beta superfamily K07018 - - 0.0000000000000000000000000000000001373 140.0
HKD2_k127_6595066_5 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001822 634.0
HKD2_k127_6595066_50 protein involved in formate dehydrogenase formation K02380 - - 0.000000000000000000000000000000000235 142.0
HKD2_k127_6595066_51 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000011 138.0
HKD2_k127_6595066_52 Cytochrome c - - - 0.000000000000000000000000000000004911 149.0
HKD2_k127_6595066_53 Cytochrome c mono- and diheme variants - - - 0.0000000000000000000000000000004662 138.0
HKD2_k127_6595066_54 Acyl transferase domain K00645 - 2.3.1.39 0.000000000000000000000000000001554 139.0
HKD2_k127_6595066_55 RNA 2'-O ribose methyltransferase substrate binding K03437 - - 0.000000000000000000000000000005166 130.0
HKD2_k127_6595066_56 Cytochrome c mono- and diheme variants - - - 0.0000000000000000000000000003133 134.0
HKD2_k127_6595066_57 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.0000000000000000000000000005052 117.0
HKD2_k127_6595066_58 PFAM response regulator receiver K07657 - - 0.000000000000000000000001271 120.0
HKD2_k127_6595066_59 - - - - 0.000000000000000000000003261 103.0
HKD2_k127_6595066_6 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 545.0
HKD2_k127_6595066_60 CoA binding domain K06929 - - 0.0000000000000000000003099 102.0
HKD2_k127_6595066_61 EamA-like transporter family - - - 0.00000000000000000001037 104.0
HKD2_k127_6595066_62 acyl-coa-binding protein - - - 0.00000000000000000001282 108.0
HKD2_k127_6595066_63 nuclear chromosome segregation - - - 0.00000000000000000002372 107.0
HKD2_k127_6595066_64 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000001461 94.0
HKD2_k127_6595066_65 peptidyl-tyrosine sulfation - - - 0.000000000000001105 92.0
HKD2_k127_6595066_66 Regulatory protein - - - 0.000000000000004033 89.0
HKD2_k127_6595066_67 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.000000000001993 73.0
HKD2_k127_6595066_68 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000002407 74.0
HKD2_k127_6595066_69 Domain of unknown function (DUF2383) - - - 0.0000000001331 68.0
HKD2_k127_6595066_7 Aminotransferase K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002 485.0
HKD2_k127_6595066_71 Domain of unknown function (DUF2383) - - - 0.000000006631 66.0
HKD2_k127_6595066_72 DegT/DnrJ/EryC1/StrS aminotransferase family K00812 - 2.6.1.1 0.0000003088 63.0
HKD2_k127_6595066_73 KaiC - - - 0.0000004031 64.0
HKD2_k127_6595066_75 bacterial OsmY and nodulation domain - - - 0.000006199 56.0
HKD2_k127_6595066_76 CsbD-like - - - 0.000009522 52.0
HKD2_k127_6595066_77 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00001328 57.0
HKD2_k127_6595066_78 Major facilitator Superfamily - - - 0.0000402 49.0
HKD2_k127_6595066_8 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 465.0
HKD2_k127_6595066_9 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004011 471.0
HKD2_k127_6622268_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799 - - 0.00000000000000000000000000000000000000002083 160.0
HKD2_k127_6622268_1 heme oxygenase (decyclizing) activity - - - 0.00000000000000000000000000006007 125.0
HKD2_k127_6622268_2 DinB superfamily - - - 0.00000000000000000000000002906 122.0
HKD2_k127_6622268_3 Metallo-beta-lactamase superfamily - - - 0.0000000000001982 75.0
HKD2_k127_6644059_0 Two component regulator propeller K07315,K12132,K13924 - 2.1.1.80,2.7.11.1,3.1.1.61,3.1.3.3 3.438e-251 812.0
HKD2_k127_6644059_1 Aspartate-ammonia ligase K01914 GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005043 640.0
HKD2_k127_6644059_10 TonB-dependent Receptor Plug Domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 390.0
HKD2_k127_6644059_11 COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 322.0
HKD2_k127_6644059_12 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007043 277.0
HKD2_k127_6644059_13 FAD dependent oxidoreductase K00303,K21061 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001407 286.0
HKD2_k127_6644059_14 ATPases associated with a variety of cellular activities K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000001046 254.0
HKD2_k127_6644059_15 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000009338 236.0
HKD2_k127_6644059_16 Binding-protein-dependent transport system inner membrane component K02050,K15554 - - 0.00000000000000000000000000000000000000000000000002389 201.0
HKD2_k127_6644059_17 Acyl-ACP thioesterase K01071 - 3.1.2.21 0.0000000000000000000000000000000001536 143.0
HKD2_k127_6644059_18 SMART protein phosphatase 2C domain protein - - - 0.000000000000000000000000000001331 141.0
HKD2_k127_6644059_19 NMT1-like family K02051 - - 0.0000000000000000000000000005243 131.0
HKD2_k127_6644059_2 Serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 594.0
HKD2_k127_6644059_20 NMT1-like family K02051 - - 0.000000000000000000000000001263 126.0
HKD2_k127_6644059_21 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.000000000000000000000004839 119.0
HKD2_k127_6644059_22 3-demethylubiquinone-9 3-O-methyltransferase activity - - - 0.00000000000000000000003195 109.0
HKD2_k127_6644059_23 - - - - 0.000004971 55.0
HKD2_k127_6644059_24 Protein involved in outer membrane biogenesis - - - 0.000006949 59.0
HKD2_k127_6644059_25 - - - - 0.00003745 46.0
HKD2_k127_6644059_26 - - - - 0.0006046 44.0
HKD2_k127_6644059_3 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000038 590.0
HKD2_k127_6644059_4 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 562.0
HKD2_k127_6644059_5 Thioesterase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 577.0
HKD2_k127_6644059_6 PFAM Aminotransferase class I and II K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001803 543.0
HKD2_k127_6644059_7 radical SAM domain protein K22318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 448.0
HKD2_k127_6644059_8 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 426.0
HKD2_k127_6644059_9 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 395.0
HKD2_k127_6649945_0 Belongs to the malate synthase family K01638 - 2.3.3.9 4.321e-230 724.0
HKD2_k127_6649945_1 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) K00322 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 585.0
HKD2_k127_6649945_10 Nitronate monooxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009819 396.0
HKD2_k127_6649945_11 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 350.0
HKD2_k127_6649945_12 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 342.0
HKD2_k127_6649945_13 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000971 312.0
HKD2_k127_6649945_14 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004403 303.0
HKD2_k127_6649945_15 serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005277 314.0
HKD2_k127_6649945_16 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000103 312.0
HKD2_k127_6649945_17 Belongs to the arylamine N-acetyltransferase family K00675 - 2.3.1.118 0.000000000000000000000000000000000000000000000000000000000000000000000005192 252.0
HKD2_k127_6649945_18 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000144 261.0
HKD2_k127_6649945_19 - - - - 0.00000000000000000000000000000000000000000000000000000000000000006795 232.0
HKD2_k127_6649945_2 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 577.0
HKD2_k127_6649945_20 Succinylglutamate desuccinylase / Aspartoacylase family K06987 - - 0.000000000000000000000000000000000000000000000000000000000000005125 231.0
HKD2_k127_6649945_21 MazG nucleotide pyrophosphohydrolase domain K04765 - 3.6.1.9 0.0000000000000000000000000000000000000000000000000000000000003919 228.0
HKD2_k127_6649945_22 PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000007716 228.0
HKD2_k127_6649945_23 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000000000000000000000000000000000000000000003525 224.0
HKD2_k127_6649945_24 MOSC domain - - - 0.00000000000000000000000000000000000000000000000000000002442 201.0
HKD2_k127_6649945_25 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000003164 214.0
HKD2_k127_6649945_26 Polyprenyl synthetase K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000002771 190.0
HKD2_k127_6649945_27 permease K03548 - - 0.00000000000000000000000000000000000000000000000002789 194.0
HKD2_k127_6649945_28 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000000000000000000000001228 176.0
HKD2_k127_6649945_29 endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000006854 168.0
HKD2_k127_6649945_3 Aminotransferase class-V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003865 528.0
HKD2_k127_6649945_30 Divergent polysaccharide deacetylase K09798 - - 0.00000000000000000000000000000000000000002255 165.0
HKD2_k127_6649945_31 tail specific protease K03797 - 3.4.21.102 0.0000000000000000000000000000000000000003633 167.0
HKD2_k127_6649945_32 YhhN family - - - 0.0000000000000000000000000000000000000004042 160.0
HKD2_k127_6649945_33 Domain of unknown function (DUF4442) - - - 0.00000000000000000000000000000000000007418 147.0
HKD2_k127_6649945_34 Peptidase family M23 K21471 - - 0.000000000000000000000000000000000001051 156.0
HKD2_k127_6649945_35 - - - - 0.000000000000000000000000000001178 128.0
HKD2_k127_6649945_36 STAS domain K04749 - - 0.000000000000000000000000000001948 135.0
HKD2_k127_6649945_37 Tetratricopeptide repeat - - - 0.00000000000000000000000000001434 136.0
HKD2_k127_6649945_38 CHASE3 domain - - - 0.00000000000000000000000000001687 136.0
HKD2_k127_6649945_39 Protein of unknown function (DUF4239) - - - 0.00000000000000000000000000008483 126.0
HKD2_k127_6649945_4 Protein of unknown function (DUF3641) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 516.0
HKD2_k127_6649945_40 Zn peptidase - - - 0.0000000000000000000000000003525 129.0
HKD2_k127_6649945_41 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000131 130.0
HKD2_k127_6649945_42 Protein phosphatase 2C domain K07315 - 3.1.3.3 0.0000000000000000000000002901 121.0
HKD2_k127_6649945_43 Ketosteroid K06893 - - 0.0000000000000000000001842 111.0
HKD2_k127_6649945_44 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.000000000000000000001514 110.0
HKD2_k127_6649945_45 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.0000000000000000002721 96.0
HKD2_k127_6649945_46 glycolate biosynthetic process K01091,K07058 - 3.1.3.18 0.00000000000002925 81.0
HKD2_k127_6649945_47 - - - - 0.0000000000001079 78.0
HKD2_k127_6649945_48 cheY-homologous receiver domain K03413 - - 0.000000000000195 78.0
HKD2_k127_6649945_49 - - - - 0.000000000002057 79.0
HKD2_k127_6649945_5 PFAM Acyl-CoA dehydrogenase K09456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004566 505.0
HKD2_k127_6649945_50 Domain of unknown function (DUF1844) - - - 0.00001744 53.0
HKD2_k127_6649945_51 CAAX protease self-immunity K07052 - - 0.000715 50.0
HKD2_k127_6649945_6 Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002084 439.0
HKD2_k127_6649945_7 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 412.0
HKD2_k127_6649945_8 Sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009369 390.0
HKD2_k127_6649945_9 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 384.0
HKD2_k127_6664046_0 ABC transporter, transmembrane K18889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 532.0
HKD2_k127_6664046_1 P-type ATPase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002911 507.0
HKD2_k127_6664046_2 (ABC) transporter K06147,K18890 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 539.0
HKD2_k127_6664046_3 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007033 324.0
HKD2_k127_6664046_4 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004433 306.0
HKD2_k127_6664046_5 Domain of unknown function (DUF4412) - - - 0.0000000000000000000000000000000002593 143.0
HKD2_k127_6664046_6 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000009924 133.0
HKD2_k127_6673864_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 532.0
HKD2_k127_6673864_1 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006489 373.0
HKD2_k127_6673864_2 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007102 301.0
HKD2_k127_6673864_3 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000005746 94.0
HKD2_k127_6673864_4 nuclear chromosome segregation - - - 0.00000001302 67.0
HKD2_k127_6709059_0 Sodium/calcium exchanger protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000576 442.0
HKD2_k127_6709059_1 Protein of unknown function (DUF2950) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 367.0
HKD2_k127_6709059_2 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000001392 213.0
HKD2_k127_6789469_0 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001144 273.0
HKD2_k127_6789469_1 - - - - 0.000000000000000000000000000000000000002132 160.0
HKD2_k127_6789469_2 chlorophyll binding K03286,K03640 - - 0.000000000000000496 83.0
HKD2_k127_6885076_0 Succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1044.0
HKD2_k127_6885076_1 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006003 439.0
HKD2_k127_6885076_2 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 421.0
HKD2_k127_6885076_3 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000519 408.0
HKD2_k127_6885076_4 Dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 300.0
HKD2_k127_6885076_5 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003447 304.0
HKD2_k127_6885076_6 fumarate reductase) cytochrome b subunit K00241 - - 0.000000000000000000000000000000000000000000000000000000000544 222.0
HKD2_k127_6885076_7 PFAM Cation H exchanger K03316 - - 0.0000000000000000000000000000000000000000000000000000003892 202.0
HKD2_k127_6885076_8 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000002078 156.0
HKD2_k127_700513_0 histidine kinase, HAMP - - - 0.0000000000000000000000000000000000000000000000000000000000000000002983 261.0
HKD2_k127_700513_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000001312 135.0
HKD2_k127_700513_2 response regulator K02481,K07713 - - 0.0000000000000000000000000002657 119.0
HKD2_k127_700513_3 Pfam LysE type translocator - - - 0.0007687 49.0
HKD2_k127_7095253_0 Predicted Permease Membrane Region K07085 - - 2.289e-202 646.0
HKD2_k127_7095253_1 Inorganic ion transport and metabolism K03319 - - 0.00000000000000000002845 92.0
HKD2_k127_7095253_2 EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D K01424,K05597 GO:0003674,GO:0003824,GO:0004067,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006530,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0032787,GO:0034641,GO:0042597,GO:0042802,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0072329,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.1,3.5.1.38 0.000000006811 60.0
HKD2_k127_7096476_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 510.0
HKD2_k127_7096476_1 Proline dehydrogenase K00318 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 309.0
HKD2_k127_7096476_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001957 252.0
HKD2_k127_7096476_3 AsnC family - - - 0.00000000000000000000000000000007476 129.0
HKD2_k127_7096476_4 ComF family - - - 0.0000000000000000000000000004807 124.0
HKD2_k127_7096476_5 Histidine kinase - - - 0.000000000000006722 89.0
HKD2_k127_7159129_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K01006 - 2.7.9.1 1.066e-308 959.0
HKD2_k127_7159129_1 gluconolactonase activity K04771 - 3.4.21.107 0.00000000000000000000000000000000000000001733 166.0
HKD2_k127_7172147_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1103.0
HKD2_k127_7172147_1 Protein involved in meta-pathway of phenol degradation - - - 0.00000000000000000000002042 104.0
HKD2_k127_7172147_2 Putative regulatory protein - - - 0.000000009501 66.0
HKD2_k127_7340159_0 S-adenosylhomocysteine deaminase activity - - - 5.459e-260 833.0
HKD2_k127_7340159_1 Uracil DNA glycosylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 351.0
HKD2_k127_7340159_2 polysaccharide deacetylase - - - 0.000000000000001567 81.0
HKD2_k127_7700342_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 632.0
HKD2_k127_7700342_1 PFAM short-chain dehydrogenase reductase SDR K15314 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000811 402.0
HKD2_k127_7700342_10 Thioesterase-like superfamily K07107 - - 0.0000000000000007089 91.0
HKD2_k127_7700342_11 Belongs to the peptidase S8 family - - - 0.00000000000003874 87.0
HKD2_k127_7700342_2 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 415.0
HKD2_k127_7700342_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003293 354.0
HKD2_k127_7700342_4 deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000000000000002103 222.0
HKD2_k127_7700342_5 response regulator K02481 - - 0.000000000000000000000000000000000000000000005148 185.0
HKD2_k127_7700342_6 Histidine kinase - - - 0.0000000000000000000000000000000002533 148.0
HKD2_k127_7700342_7 4'-phosphopantetheinyl transferase superfamily K06133 - - 0.000000000000000000000000000008668 137.0
HKD2_k127_7700342_8 beta-propeller repeat - - - 0.0000000000000000000002538 115.0
HKD2_k127_7700342_9 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - - 0.0000000000000000006736 103.0
HKD2_k127_7730553_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 1.88e-242 771.0
HKD2_k127_7730553_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 516.0
HKD2_k127_7730553_10 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate K00598 - 2.1.1.144 0.0000000000000000000000000000000000000000000000000000000000000000000000000002154 267.0
HKD2_k127_7730553_11 Belongs to the peptidase M16 family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000001222 241.0
HKD2_k127_7730553_12 glyoxalase III activity - - - 0.000000000000000000000000000000000000000000000000000000000005294 222.0
HKD2_k127_7730553_13 Allophanate hydrolase subunit 2 - - - 0.0000000000000000000000000000000000000000000000000000000002966 223.0
HKD2_k127_7730553_14 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000003766 205.0
HKD2_k127_7730553_15 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.0000000000000000000000000000000000000000000000000001871 199.0
HKD2_k127_7730553_16 LamB/YcsF family - - - 0.0000000000000000000000000000000000000000000000000007335 204.0
HKD2_k127_7730553_17 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000002583 188.0
HKD2_k127_7730553_18 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000003522 173.0
HKD2_k127_7730553_19 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000000000000000000000000003252 154.0
HKD2_k127_7730553_2 Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 404.0
HKD2_k127_7730553_20 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 0.0000000000000000000000000000000000000001695 169.0
HKD2_k127_7730553_21 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.0000000000000000000000000000000000001586 162.0
HKD2_k127_7730553_22 peroxiredoxin activity - - - 0.0000000000000000000000000000000006905 152.0
HKD2_k127_7730553_23 - - - - 0.0000000000000000000000000000003284 131.0
HKD2_k127_7730553_24 general secretion pathway protein K02456 - - 0.00000000000000000000000000000072 131.0
HKD2_k127_7730553_25 DNA-binding transcription factor activity - - - 0.00000000000000000000000000004441 119.0
HKD2_k127_7730553_26 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000001672 119.0
HKD2_k127_7730553_27 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000461 84.0
HKD2_k127_7730553_28 cell redox homeostasis - - - 0.000000000000000475 90.0
HKD2_k127_7730553_29 general secretion pathway protein K02456,K02650 - - 0.00000000000004067 84.0
HKD2_k127_7730553_3 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004923 380.0
HKD2_k127_7730553_31 ORF located using Blastx - - - 0.0000000005733 59.0
HKD2_k127_7730553_32 DUF167 K09131 - - 0.00000007191 64.0
HKD2_k127_7730553_4 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 360.0
HKD2_k127_7730553_5 ATP-grasp domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003808 370.0
HKD2_k127_7730553_6 4Fe-4S single cluster domain of Ferredoxin I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002675 328.0
HKD2_k127_7730553_7 PFAM LOR SDH bifunctional enzyme conserved region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003741 320.0
HKD2_k127_7730553_8 uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001543 277.0
HKD2_k127_7730553_9 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005709 280.0
HKD2_k127_7735112_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.762e-251 792.0
HKD2_k127_7735112_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 2.563e-212 674.0
HKD2_k127_7735112_10 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003363 399.0
HKD2_k127_7735112_11 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000508 360.0
HKD2_k127_7735112_12 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 362.0
HKD2_k127_7735112_13 Type II/IV secretion system protein K02669 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 336.0
HKD2_k127_7735112_14 GGDEF domain K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 338.0
HKD2_k127_7735112_15 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 322.0
HKD2_k127_7735112_16 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001196 338.0
HKD2_k127_7735112_17 PFAM Formylglycine-generating sulfatase enzyme K20333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008167 330.0
HKD2_k127_7735112_18 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 303.0
HKD2_k127_7735112_19 Tetrahydrodipicolinate N-succinyltransferase N-terminal K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008345 297.0
HKD2_k127_7735112_2 Rieske-like [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000855 596.0
HKD2_k127_7735112_20 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000001919 281.0
HKD2_k127_7735112_21 N-Acetylmuramoyl-L-alanine amidase K01448,K02172 - 3.5.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000004333 295.0
HKD2_k127_7735112_22 Belongs to the Orn Lys Arg decarboxylase class-II family K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000002396 254.0
HKD2_k127_7735112_23 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000001805 231.0
HKD2_k127_7735112_24 ABC-type uncharacterized transport system - - - 0.0000000000000000000000000000000000000000000000000000000007168 221.0
HKD2_k127_7735112_25 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000007907 199.0
HKD2_k127_7735112_26 Putative esterase K07017 - - 0.000000000000000000000000000000000000000000000000009474 203.0
HKD2_k127_7735112_27 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 0.00000000000000000000000000000000000000000000025 193.0
HKD2_k127_7735112_28 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000000001067 175.0
HKD2_k127_7735112_29 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000000000000001282 184.0
HKD2_k127_7735112_3 Penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007349 509.0
HKD2_k127_7735112_30 Branched-chain amino acid transport system / permease component K02057 - - 0.00000000000000000000000000000000000000000002436 179.0
HKD2_k127_7735112_31 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.00000000000000000000000000000000000000000003048 175.0
HKD2_k127_7735112_32 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000003101 183.0
HKD2_k127_7735112_33 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000004598 172.0
HKD2_k127_7735112_34 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000001047 163.0
HKD2_k127_7735112_35 binds to the 23S rRNA K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000002426 143.0
HKD2_k127_7735112_36 Alpha beta hydrolase - - - 0.0000000000000000000000000000001323 136.0
HKD2_k127_7735112_37 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000007611 141.0
HKD2_k127_7735112_38 Pentapeptide repeats (9 copies) - - - 0.000000000000000000000000000008596 139.0
HKD2_k127_7735112_39 4Fe-4S single cluster domain of Ferredoxin I K05337 - - 0.00000000000000000000000000001132 120.0
HKD2_k127_7735112_4 SMART PDZ DHR GLGF domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002222 481.0
HKD2_k127_7735112_40 ATP-dependent protease La (LON) substrate-binding domain K07157 - - 0.0000000000000000000000000005615 126.0
HKD2_k127_7735112_41 TIGRFAM type VI secretion system effector, Hcp1 family K11903 - - 0.000000000000000000000000002257 123.0
HKD2_k127_7735112_42 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000001194 115.0
HKD2_k127_7735112_43 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.0000000000000000000000002341 125.0
HKD2_k127_7735112_44 ATPases associated with a variety of cellular activities K02056 - 3.6.3.17 0.0000000000000000000001076 103.0
HKD2_k127_7735112_45 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000001657 100.0
HKD2_k127_7735112_46 Histidine kinase-like ATPase domain - - - 0.000000000000000001019 103.0
HKD2_k127_7735112_47 EamA-like transporter family - - - 0.00000000000000000189 96.0
HKD2_k127_7735112_48 Heavy-metal resistance - - - 0.00000000000000003476 90.0
HKD2_k127_7735112_49 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K10819 - 2.7.13.3 0.00000000000001151 89.0
HKD2_k127_7735112_5 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 458.0
HKD2_k127_7735112_50 STAS domain K04749 - - 0.0000000000002571 80.0
HKD2_k127_7735112_51 Lipopolysaccharide kinase (Kdo/WaaP) family - - - 0.000000000001314 77.0
HKD2_k127_7735112_52 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000004825 72.0
HKD2_k127_7735112_53 Domain of unknown function (DUF4340) - - - 0.000000000005653 80.0
HKD2_k127_7735112_54 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000236 72.0
HKD2_k127_7735112_55 Membrane - - - 0.00000009 65.0
HKD2_k127_7735112_56 Predicted membrane protein (DUF2232) - - - 0.000007352 58.0
HKD2_k127_7735112_57 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00003012 50.0
HKD2_k127_7735112_58 Anti-sigma-K factor rskA - - - 0.00007694 53.0
HKD2_k127_7735112_6 e3 binding domain K00658 - 2.3.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009597 420.0
HKD2_k127_7735112_7 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005772 419.0
HKD2_k127_7735112_8 Transketolase, pyrimidine binding domain K00167 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 428.0
HKD2_k127_7735112_9 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 389.0
HKD2_k127_7738736_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 575.0
HKD2_k127_7738736_1 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007448 481.0
HKD2_k127_7738736_10 Tetratricopeptide repeats - - - 0.00000000000000000000000000000002506 145.0
HKD2_k127_7738736_11 ATP synthesis coupled electron transport K00340,K05576 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 0.0000000000000000000006812 106.0
HKD2_k127_7738736_12 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000005099 108.0
HKD2_k127_7738736_13 Yip1 domain - - - 0.000000000000007117 89.0
HKD2_k127_7738736_14 NADH-quinone oxidoreductase K00336 - 1.6.5.3 0.000000002408 64.0
HKD2_k127_7738736_2 Belongs to the deoxyhypusine synthase family K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007757 477.0
HKD2_k127_7738736_3 quinone binding K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007311 351.0
HKD2_k127_7738736_4 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 332.0
HKD2_k127_7738736_5 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 317.0
HKD2_k127_7738736_6 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000713 306.0
HKD2_k127_7738736_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000101 314.0
HKD2_k127_7738736_8 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000006256 243.0
HKD2_k127_7738736_9 Modulates transcription in response to changes in cellular NADH NAD( ) redox state K01926 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.00000000000000000000000000000000000000001732 175.0
HKD2_k127_7763359_0 Ankyrin repeat - - - 0.00000000000000000001344 101.0
HKD2_k127_7763359_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.00000000000108 78.0
HKD2_k127_7763359_2 protein ubiquitination K15502 - - 0.000000000005613 78.0
HKD2_k127_7763359_3 Endothelin-converting enzyme K01415,K07386 - 3.4.24.71 0.000004062 59.0
HKD2_k127_7872092_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1147.0
HKD2_k127_7872092_1 Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate K01782,K01825 GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 2.049e-285 893.0
HKD2_k127_7872092_10 Transport permease protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 324.0
HKD2_k127_7872092_11 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 306.0
HKD2_k127_7872092_12 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004387 311.0
HKD2_k127_7872092_13 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004941 246.0
HKD2_k127_7872092_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000005558 234.0
HKD2_k127_7872092_15 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000685 244.0
HKD2_k127_7872092_16 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000001077 235.0
HKD2_k127_7872092_17 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000005758 203.0
HKD2_k127_7872092_18 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000243 166.0
HKD2_k127_7872092_19 Barrel-sandwich domain of CusB or HlyD membrane-fusion K01993 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944 - 0.00000000000000000000000000000000000000000002588 173.0
HKD2_k127_7872092_2 Peptidase family M41 K03798 - - 1.221e-236 753.0
HKD2_k127_7872092_20 PFAM Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000001414 176.0
HKD2_k127_7872092_21 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000000000001488 128.0
HKD2_k127_7872092_22 PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK K00950 - 2.7.6.3 0.000000000000000000000000000001462 130.0
HKD2_k127_7872092_23 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.0000000000000000000000008579 118.0
HKD2_k127_7872092_24 Dodecin K09165 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - 0.000000000000000000000005053 102.0
HKD2_k127_7872092_25 Preprotein translocase subunit K03210 - - 0.00000000000000000002013 95.0
HKD2_k127_7872092_26 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000002187 100.0
HKD2_k127_7872092_27 Protein of unknown function (DUF3467) - - - 0.000000000000005481 87.0
HKD2_k127_7872092_28 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000001803 78.0
HKD2_k127_7872092_29 Protein of unknown function (FYDLN_acid) - - - 0.000000000008738 73.0
HKD2_k127_7872092_3 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 1.197e-234 736.0
HKD2_k127_7872092_31 Tetratricopeptide repeat - - - 0.000000005869 68.0
HKD2_k127_7872092_32 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000001152 61.0
HKD2_k127_7872092_33 Thioredoxin-like K01829 - 5.3.4.1 0.0000003628 61.0
HKD2_k127_7872092_34 DNA alkylation repair enzyme - - - 0.000001997 58.0
HKD2_k127_7872092_36 Psort location - - - 0.0008081 52.0
HKD2_k127_7872092_4 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed K00632 - 2.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002425 555.0
HKD2_k127_7872092_5 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006981 411.0
HKD2_k127_7872092_6 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002847 366.0
HKD2_k127_7872092_7 LysR substrate binding domain K03717 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009095 351.0
HKD2_k127_7872092_8 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000776 323.0
HKD2_k127_7872092_9 TIGRFAM serine O-acetyltransferase K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001336 307.0
HKD2_k127_7969128_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003521 313.0
HKD2_k127_7969128_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001111 268.0
HKD2_k127_7969128_2 Sulfatase-modifying factor enzyme 1 K01176,K01206,K01218,K01219,K01224 - 3.2.1.1,3.2.1.51,3.2.1.78,3.2.1.81,3.2.1.89 0.00000000000000000000000000000000000000002796 169.0
HKD2_k127_8026556_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 577.0
HKD2_k127_8026556_1 Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate K00598 - 2.1.1.144 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001122 276.0
HKD2_k127_8026556_2 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000003405 268.0
HKD2_k127_8026556_3 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000009037 239.0
HKD2_k127_8026556_4 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.00000000000000000000000000000000000000000000000000000002296 221.0
HKD2_k127_8026556_5 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000003973 192.0
HKD2_k127_8026556_6 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 0.000000000000000000000000000000000000000007524 161.0
HKD2_k127_8026556_7 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000004706 107.0
HKD2_k127_8026556_8 Belongs to the UPF0235 family K09131 - - 0.0002686 54.0
HKD2_k127_8031072_0 glycosyl transferase family 2 K20444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 297.0
HKD2_k127_8031072_1 ATPases associated with a variety of cellular activities K09689,K09691 - 3.6.3.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 299.0
HKD2_k127_8031072_10 Glycosyl transferase, family 2 - - - 0.0000000000000001052 92.0
HKD2_k127_8031072_11 PFAM Glycosyl transferases group 1 - - - 0.00000000000002063 87.0
HKD2_k127_8031072_12 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000006969 87.0
HKD2_k127_8031072_13 - - - - 0.0000000000008656 81.0
HKD2_k127_8031072_14 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.0000000004208 72.0
HKD2_k127_8031072_15 transferase activity, transferring acyl groups - - - 0.0000000005472 70.0
HKD2_k127_8031072_16 methyltransferase activity - - - 0.000001634 61.0
HKD2_k127_8031072_2 response regulator K07713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004599 290.0
HKD2_k127_8031072_3 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000001074 268.0
HKD2_k127_8031072_4 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000004819 254.0
HKD2_k127_8031072_5 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000000001042 187.0
HKD2_k127_8031072_6 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000003841 148.0
HKD2_k127_8031072_7 Glycosyltransferase, group 2 family protein - - - 0.0000000000000000000000000000008679 136.0
HKD2_k127_8031072_8 sigma factor antagonist activity K04757 - 2.7.11.1 0.0000000000000000000004188 102.0
HKD2_k127_8031072_9 Transcriptional regulatory protein, C terminal - - - 0.00000000000000003853 95.0
HKD2_k127_8066966_0 Hydrophobe amphiphile Efflux-1 (HAE1) family K03296,K18138 - - 0.0 1690.0
HKD2_k127_8066966_1 Hydrophobe amphiphile Efflux-1 (HAE1) family K03296,K18138 - - 0.0 1261.0
HKD2_k127_8066966_10 Belongs to the glutaminase family K01425 - 3.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004267 432.0
HKD2_k127_8066966_11 AMP-binding enzyme C-terminal domain K18660,K18661 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 433.0
HKD2_k127_8066966_12 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001281 430.0
HKD2_k127_8066966_13 Sodium:solute symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008622 407.0
HKD2_k127_8066966_14 Belongs to the asparaginase 1 family K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 397.0
HKD2_k127_8066966_15 Biotin-lipoyl like K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 372.0
HKD2_k127_8066966_16 ATP-dependent DNA helicase activity K01144,K07464,K16898 - 3.1.11.5,3.1.12.1,3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008298 388.0
HKD2_k127_8066966_17 Predicted Permease Membrane Region K07085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 345.0
HKD2_k127_8066966_18 ABC transporter K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 366.0
HKD2_k127_8066966_19 FeS assembly protein SufD K07033,K09015 GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001838 355.0
HKD2_k127_8066966_2 Insulinase (Peptidase family M16) K07263 - - 0.0 1212.0
HKD2_k127_8066966_20 PFAM Homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000652 323.0
HKD2_k127_8066966_21 long-chain fatty acid transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 297.0
HKD2_k127_8066966_22 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000001197 220.0
HKD2_k127_8066966_23 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000000000000000000000000000000000000000479 225.0
HKD2_k127_8066966_24 Protein of unknown function (DUF1572) - - - 0.0000000000000000000000000000000000000000000000000003169 193.0
HKD2_k127_8066966_25 NifU-like N terminal domain K04488 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - 0.0000000000000000000000000000000000000000000000001465 198.0
HKD2_k127_8066966_27 Transcriptional regulator - - - 0.0000000000000000000000000000000000000002462 156.0
HKD2_k127_8066966_28 TIGRFAM Diguanylate cyclase - - - 0.000000000000000000000000000002703 132.0
HKD2_k127_8066966_29 metal-sulfur cluster biosynthetic enzyme K02612 - - 0.00000000000000000000000000001278 128.0
HKD2_k127_8066966_3 FeS assembly protein SufB K07033,K09014 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - 1.449e-250 788.0
HKD2_k127_8066966_30 - - - - 0.00000000000000000002669 97.0
HKD2_k127_8066966_31 - - - - 0.00000000000000000007806 98.0
HKD2_k127_8066966_32 PD-(D/E)XK nuclease superfamily - - - 0.00000000000001445 89.0
HKD2_k127_8066966_33 Domain of unknown function (DUF4410) - - - 0.00000000000003301 81.0
HKD2_k127_8066966_4 Domain of Unknown Function with PDB structure (DUF3857) - - - 5.444e-244 804.0
HKD2_k127_8066966_5 Peptidase m28 - - - 8.664e-222 702.0
HKD2_k127_8066966_6 TIGRFAM RND efflux system, outer membrane lipoprotein, NodT K18139 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008348 624.0
HKD2_k127_8066966_7 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 563.0
HKD2_k127_8066966_8 HlyD membrane-fusion protein of T1SS K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 500.0
HKD2_k127_8066966_9 COG NOG10142 non supervised orthologous group - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001686 487.0
HKD2_k127_8080718_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process K03385 - 1.7.2.2 1.648e-217 687.0
HKD2_k127_8080718_1 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005881 506.0
HKD2_k127_8080718_10 cytochrome c nitrite reductase K15876 - - 0.00000000000000000000000000000000000000000000000000000000000433 211.0
HKD2_k127_8080718_11 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000001314 223.0
HKD2_k127_8080718_12 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.00000000000000000000000000000000000000000000000000000002808 223.0
HKD2_k127_8080718_13 PFAM cytochrome c assembly protein - - - 0.000000000000000000001373 105.0
HKD2_k127_8080718_14 FHA domain K07315 - 3.1.3.3 0.00000000000001151 84.0
HKD2_k127_8080718_15 PFAM Tetrapyrrole (Corrin Porphyrin) Methylases K13542 - 2.1.1.107,4.2.1.75 0.0000000001253 74.0
HKD2_k127_8080718_16 Transcriptional regulatory protein, C terminal - - - 0.0000000004766 70.0
HKD2_k127_8080718_2 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 483.0
HKD2_k127_8080718_3 Involved in the biosynthesis of porphyrin-containing compound K02495 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 424.0
HKD2_k127_8080718_4 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004201 421.0
HKD2_k127_8080718_5 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 309.0
HKD2_k127_8080718_6 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008479 294.0
HKD2_k127_8080718_7 Belongs to the DegT DnrJ EryC1 family K02805,K07806 - 2.6.1.59,2.6.1.87 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004871 279.0
HKD2_k127_8080718_8 Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000000000000000000008114 259.0
HKD2_k127_8080718_9 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000001361 242.0
HKD2_k127_821677_0 COG1104 Cysteine sulfinate desulfinase cysteine desulfurase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000544 449.0
HKD2_k127_821677_1 PFAM Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 319.0
HKD2_k127_821677_2 protein kinase activity K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 321.0
HKD2_k127_821677_3 HpcH/HpaI aldolase/citrate lyase family K02510 - 4.1.2.52 0.0000000000000000000000000000000000000000000000000000000000000000001674 238.0
HKD2_k127_821677_4 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000001835 141.0
HKD2_k127_821677_5 PAP2 superfamily - - - 0.000000000000000000558 98.0
HKD2_k127_826105_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0 1333.0
HKD2_k127_826105_1 lipopolysaccharide transport K22110 - - 0.0 1127.0
HKD2_k127_826105_10 6-phosphogluconolactonase K00851,K01057 - 2.7.1.12,3.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000001916 273.0
HKD2_k127_826105_2 Phosphoglucose isomerase K01810 - 5.3.1.9 6.823e-286 897.0
HKD2_k127_826105_3 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835 - 5.4.2.2 3.083e-253 831.0
HKD2_k127_826105_4 Glucose-6-phosphate dehydrogenase, NAD binding domain K00036 - 1.1.1.363,1.1.1.49 6.801e-216 679.0
HKD2_k127_826105_5 STAS domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 602.0
HKD2_k127_826105_6 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 548.0
HKD2_k127_826105_7 Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella K18691 GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007254 519.0
HKD2_k127_826105_8 Transcriptional regulator sugar kinase K00886 - 2.7.1.63 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005066 316.0
HKD2_k127_826105_9 Phosphoglycerate mutase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002246 272.0
HKD2_k127_828217_0 COG0433 Predicted ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 456.0
HKD2_k127_828217_1 peptidase M24B X-Pro dipeptidase aminopeptidase domain protein K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001257 439.0
HKD2_k127_828217_10 SMART phosphoesterase PA-phosphatase related - - - 0.000000000000000000000000000000000000000000001247 191.0
HKD2_k127_828217_11 - - - - 0.0000000000000000000000000000000000000002281 157.0
HKD2_k127_828217_12 - - - - 0.00000000000000000000000000000000001052 141.0
HKD2_k127_828217_13 Acyltransferase K00655 GO:0003674,GO:0003824,GO:0003841,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042171,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071617,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.3.1.51 0.0000000000000000000000000000000008572 140.0
HKD2_k127_828217_14 Thioesterase superfamily K10806 - - 0.000000000000000000000000000002526 126.0
HKD2_k127_828217_15 Translation initiation factor SUI1 K03113 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000001787 117.0
HKD2_k127_828217_16 RF-1 domain K15034 - - 0.000000000000000000000000002412 116.0
HKD2_k127_828217_17 protein involved in formate dehydrogenase formation K02380 - - 0.00000000000000000000001823 110.0
HKD2_k127_828217_18 antisigma factor binding - - - 0.000000000000000001563 89.0
HKD2_k127_828217_19 response to abiotic stimulus K21440 - - 0.000001214 60.0
HKD2_k127_828217_2 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003346 434.0
HKD2_k127_828217_20 gag-polyprotein putative aspartyl protease K06985 - - 0.000001889 62.0
HKD2_k127_828217_3 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01431 - 3.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 435.0
HKD2_k127_828217_4 desaturase K00507 - 1.14.19.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 320.0
HKD2_k127_828217_5 HI0933-like protein K07007 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002254 319.0
HKD2_k127_828217_6 TIGRFAM Na H antiporter, bacterial form K03316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009415 296.0
HKD2_k127_828217_7 peroxiredoxin activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003166 269.0
HKD2_k127_828217_8 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000006384 250.0
HKD2_k127_828217_9 Serine phosphatase RsbU regulator of sigma subunit K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000002084 212.0
HKD2_k127_8316628_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004829 499.0
HKD2_k127_8316628_1 PFAM Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 413.0
HKD2_k127_8316628_10 NAD(P)H-binding K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000772 196.0
HKD2_k127_8316628_11 NUDIX domain - - - 0.000000000000000000000000000000000000007586 164.0
HKD2_k127_8316628_12 PAP2 superfamily - - - 0.00000000000000000000000000000000001654 156.0
HKD2_k127_8316628_13 Protein tyrosine kinase - - - 0.0000000000001063 74.0
HKD2_k127_8316628_14 peptidoglycan binding K02453,K03749 GO:0000910,GO:0003674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0022402,GO:0030428,GO:0032153,GO:0032506,GO:0042834,GO:0044464,GO:0051301,GO:0097367 - 0.0000009945 61.0
HKD2_k127_8316628_15 Tetratricopeptide repeat - - - 0.0000179 57.0
HKD2_k127_8316628_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004665 385.0
HKD2_k127_8316628_3 acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009282 324.0
HKD2_k127_8316628_4 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003923 321.0
HKD2_k127_8316628_5 PFAM Band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008468 314.0
HKD2_k127_8316628_6 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001113 297.0
HKD2_k127_8316628_7 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004079 280.0
HKD2_k127_8316628_8 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000007341 249.0
HKD2_k127_8316628_9 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000000000000000000000000002601 219.0
HKD2_k127_8350323_0 membrane protein, TerC K05794 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 391.0
HKD2_k127_8350323_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 381.0
HKD2_k127_8350323_2 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001565 344.0
HKD2_k127_8350323_3 TIGRFAM Bacterial surface protein 26-residue repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 342.0
HKD2_k127_8350323_4 Predicted membrane protein (DUF2238) K08984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002882 283.0
HKD2_k127_8350323_5 PFAM NHL repeat containing protein K13735 - - 0.00000000001766 78.0
HKD2_k127_8426106_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 2.658e-256 803.0
HKD2_k127_8426106_1 Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003071 451.0
HKD2_k127_8426106_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004129 312.0
HKD2_k127_8426106_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000007084 253.0
HKD2_k127_8426106_4 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000006119 194.0
HKD2_k127_8426106_5 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 0.0000000000000000000000000000000000002094 160.0
HKD2_k127_8426106_6 belongs to the phosphoglycerate kinase family K00927,K01803 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3,5.3.1.1 0.000000000000000000000001591 109.0
HKD2_k127_8426106_7 Calcium/calmodulin dependent protein kinase II association domain - - - 0.000000000000000000001979 99.0
HKD2_k127_8426106_8 S4 RNA-binding domain K04762 - - 0.00000000000000000003138 96.0
HKD2_k127_8471279_0 gluconolactonase activity - - - 0.000000000000000000000000000000000000000000000000007414 206.0
HKD2_k127_8471279_1 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000001311 205.0
HKD2_k127_8480424_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 447.0
HKD2_k127_8480424_1 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000004853 263.0
HKD2_k127_8480424_2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000002457 179.0
HKD2_k127_8480424_3 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.000000000000000000000000000000000000000002601 159.0
HKD2_k127_8480424_4 Tetratricopeptide repeats - - - 0.000000000000000000000000000000000000001255 167.0
HKD2_k127_8480424_5 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.0000000000000000000000000002022 124.0
HKD2_k127_8480424_6 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000001943 91.0
HKD2_k127_8511657_0 B12 binding domain K00548 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 0.0 1580.0
HKD2_k127_8511657_1 DEAD DEAH box helicase - - - 2.802e-263 839.0
HKD2_k127_8511657_10 peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005982 535.0
HKD2_k127_8511657_11 carboxylic ester hydrolase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001442 497.0
HKD2_k127_8511657_12 Homocysteine S-methyltransferase K00297,K00547 - 1.5.1.20,2.1.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006872 458.0
HKD2_k127_8511657_13 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008546 445.0
HKD2_k127_8511657_14 Acetoacetate decarboxylase (ADC) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 405.0
HKD2_k127_8511657_16 homoserine kinase activity K02204,K13059 - 2.7.1.162,2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003075 364.0
HKD2_k127_8511657_17 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 353.0
HKD2_k127_8511657_18 Major royal jelly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 331.0
HKD2_k127_8511657_19 PFAM peptidase C14, caspase catalytic - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002395 290.0
HKD2_k127_8511657_2 cellulose binding - - - 6.562e-230 715.0
HKD2_k127_8511657_20 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 317.0
HKD2_k127_8511657_21 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001897 297.0
HKD2_k127_8511657_22 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005649 276.0
HKD2_k127_8511657_23 Zinc-dependent metalloprotease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003257 272.0
HKD2_k127_8511657_24 alpha/beta hydrolase fold K07019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001077 278.0
HKD2_k127_8511657_25 LytTr DNA-binding domain K02477 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000714 262.0
HKD2_k127_8511657_27 PFAM Peptidoglycan-binding domain 1 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001691 247.0
HKD2_k127_8511657_28 PFAM ROK family K00845 - 2.7.1.2 0.000000000000000000000000000000000000000000000000000000000000004557 228.0
HKD2_k127_8511657_29 PFAM UbiA prenyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000006186 219.0
HKD2_k127_8511657_3 COG2303 Choline dehydrogenase and related flavoproteins K03333 - 1.1.3.6 1.056e-227 747.0
HKD2_k127_8511657_31 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000006012 199.0
HKD2_k127_8511657_33 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000006235 186.0
HKD2_k127_8511657_34 stage 0 sporulation protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000006811 174.0
HKD2_k127_8511657_35 Mo-molybdopterin cofactor metabolic process K03636,K21147 - 2.7.7.80,2.8.1.11 0.00000000000000000000000000000000000000005379 153.0
HKD2_k127_8511657_36 Cell wall-active antibiotics response 4TMS YvqF - - - 0.000000000000000000000000000000000000002435 158.0
HKD2_k127_8511657_37 PFAM SMP-30 Gluconolaconase - - - 0.00000000000000000000000000000000000004231 149.0
HKD2_k127_8511657_38 - - - - 0.0000000000000000000000000000000000004191 162.0
HKD2_k127_8511657_39 D-arabinono-1,4-lactone oxidase - - - 0.00000000000000000000000000000000000231 160.0
HKD2_k127_8511657_4 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 622.0
HKD2_k127_8511657_40 Oxidoreductase - - - 0.0000000000000000000000000000000003976 151.0
HKD2_k127_8511657_41 Patatin-like phospholipase - - - 0.00000000000000000000000000000009216 136.0
HKD2_k127_8511657_42 Hfq protein - - - 0.0000000000000000000000000009764 117.0
HKD2_k127_8511657_43 amine dehydrogenase activity - - - 0.000000000000000000000001087 123.0
HKD2_k127_8511657_44 - - - - 0.00000000000000003824 94.0
HKD2_k127_8511657_45 - - - - 0.00000000000000004489 87.0
HKD2_k127_8511657_46 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000004581 98.0
HKD2_k127_8511657_47 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB) K10672,K10794 - 1.21.4.1,1.21.4.2 0.0000000000000005364 80.0
HKD2_k127_8511657_48 Male sterility protein - - - 0.0000000000000006604 93.0
HKD2_k127_8511657_49 - - - - 0.0000000000000006859 87.0
HKD2_k127_8511657_5 Esterase of the alpha-beta hydrolase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 601.0
HKD2_k127_8511657_50 lipolytic protein G-D-S-L family - - - 0.00000000000002166 85.0
HKD2_k127_8511657_51 DinB family - - - 0.00000000001998 71.0
HKD2_k127_8511657_52 helix_turn_helix, arabinose operon control protein - - - 0.00007506 50.0
HKD2_k127_8511657_53 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00008366 57.0
HKD2_k127_8511657_54 - - - - 0.0001347 52.0
HKD2_k127_8511657_55 PASTA domain - - - 0.0001523 54.0
HKD2_k127_8511657_56 Histidine kinase - - - 0.0002956 55.0
HKD2_k127_8511657_57 zinc ion binding K11997 - - 0.0003312 55.0
HKD2_k127_8511657_6 serine-type peptidase activity K01278 - 3.4.14.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 614.0
HKD2_k127_8511657_7 amine dehydrogenase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002917 594.0
HKD2_k127_8511657_8 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008893 551.0
HKD2_k127_8511657_9 Uncharacterized membrane protein (DUF2298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 578.0
HKD2_k127_855445_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1224.0
HKD2_k127_855445_1 PFAM Prolyl oligopeptidase family - - - 7.55e-307 952.0
HKD2_k127_855445_10 domain, Protein K20276 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 398.0
HKD2_k127_855445_11 Dihydroxyacetone kinase family K07030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 385.0
HKD2_k127_855445_12 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 376.0
HKD2_k127_855445_13 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 362.0
HKD2_k127_855445_14 Protein of unknown function (DUF1501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002691 367.0
HKD2_k127_855445_15 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 350.0
HKD2_k127_855445_16 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 327.0
HKD2_k127_855445_17 Aldehyde dehydrogenase family K00128 - 1.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002829 294.0
HKD2_k127_855445_18 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 288.0
HKD2_k127_855445_19 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006504 290.0
HKD2_k127_855445_2 PFAM Prolyl oligopeptidase family - - - 4.153e-271 852.0
HKD2_k127_855445_20 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000123 285.0
HKD2_k127_855445_21 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009193 277.0
HKD2_k127_855445_22 KH domain K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001414 277.0
HKD2_k127_855445_23 Protein of unknown function (DUF2911) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009746 261.0
HKD2_k127_855445_24 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000001712 258.0
HKD2_k127_855445_25 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000001124 231.0
HKD2_k127_855445_26 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000002249 248.0
HKD2_k127_855445_27 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000003639 237.0
HKD2_k127_855445_28 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.000000000000000000000000000000000000000000000000000000000004264 237.0
HKD2_k127_855445_29 ADP-ribosylation factor family K06883 - - 0.000000000000000000000000000000000000000000000000000000308 219.0
HKD2_k127_855445_3 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.413e-206 665.0
HKD2_k127_855445_30 Transporter associated domain - - - 0.00000000000000000000000000000000000000000000001131 192.0
HKD2_k127_855445_31 of the beta-lactamase K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000002718 169.0
HKD2_k127_855445_32 phosphatase activity K01560,K07025,K08723,K20862 GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006206,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008655,GO:0009058,GO:0009112,GO:0009410,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019438,GO:0019856,GO:0019859,GO:0030145,GO:0034641,GO:0034654,GO:0042221,GO:0042578,GO:0043094,GO:0043100,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.3.102,3.1.3.104,3.1.3.5,3.8.1.2 0.00000000000000000000000000000000000005706 160.0
HKD2_k127_855445_33 PFAM membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.000000000000000000000000000000000008583 158.0
HKD2_k127_855445_34 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000009584 151.0
HKD2_k127_855445_35 Protein of unknown function (DUF421) - - - 0.000000000000000000000000000000001066 151.0
HKD2_k127_855445_36 PFAM OmpA MotB domain protein K03640 - - 0.000000000000000000000000000000002775 140.0
HKD2_k127_855445_37 GDSL family lipolytic protein - - - 0.00000000000000000000000000000003199 143.0
HKD2_k127_855445_38 methyltransferase activity K04786,K12240,K13613,K15677 - - 0.00000000000000000000000000001227 125.0
HKD2_k127_855445_39 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.000000000000000000000000001143 115.0
HKD2_k127_855445_4 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000727 569.0
HKD2_k127_855445_40 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000001307 109.0
HKD2_k127_855445_41 Peptidase family M23 K21472 - - 0.000000000000000000000002648 117.0
HKD2_k127_855445_42 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000002794 109.0
HKD2_k127_855445_43 Hemerythrin HHE cation binding domain - - - 0.00000000000000000009196 104.0
HKD2_k127_855445_44 YCII-related domain - - - 0.00000000000000001776 92.0
HKD2_k127_855445_45 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000001963 93.0
HKD2_k127_855445_46 heat shock protein binding - - - 0.00000000000001361 85.0
HKD2_k127_855445_48 UPF0761 membrane protein K07058 - - 0.00001078 57.0
HKD2_k127_855445_49 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.0001135 55.0
HKD2_k127_855445_5 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 480.0
HKD2_k127_855445_50 - - - - 0.0002392 48.0
HKD2_k127_855445_6 Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction K02377 - 1.1.1.271 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009818 427.0
HKD2_k127_855445_7 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007641 417.0
HKD2_k127_855445_8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005551 394.0
HKD2_k127_855445_9 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001638 411.0
HKD2_k127_8580057_0 Catalyzes the synthesis of activated sulfate K00958 - 2.7.7.4 8.001e-211 662.0
HKD2_k127_8580057_1 Glycosyl transferases group 1 - - - 8.355e-205 655.0
HKD2_k127_8580057_10 Belongs to the peptidase S8 family K20276 - - 0.000000003462 70.0
HKD2_k127_8580057_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 1.166e-201 656.0
HKD2_k127_8580057_3 ABC transporter related K01990,K09691 - - 0.0000000000000000000000000000000000000000000000000000000000000000000638 240.0
HKD2_k127_8580057_4 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000001618 233.0
HKD2_k127_8580057_5 Part of the ABC transporter complex LolCDE involved in the translocation of K02003 - - 0.000000000000000000000000000000000000000000000000000003904 198.0
HKD2_k127_8580057_6 ABC-2 type transporter K09690 - - 0.0000000000000000000000000000000000000000000009794 184.0
HKD2_k127_8580057_7 Sulfatase - - - 0.000000000000000000000000000000000000000000003699 188.0
HKD2_k127_8580057_8 - - - - 0.00000000000000000000000000000000000000000003614 173.0
HKD2_k127_8580057_9 ABC-type transport system involved in lipoprotein release permease component K02004 - - 0.0000000000000000000000000536 124.0
HKD2_k127_8676538_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K06281 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016151,GO:0016491,GO:0022900,GO:0030288,GO:0030313,GO:0031975,GO:0032991,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0044569,GO:0045333,GO:0046872,GO:0046914,GO:0055114,GO:0071944,GO:1902494 1.12.99.6 3.39e-289 917.0
HKD2_k127_8676538_1 NiFe/NiFeSe hydrogenase small subunit C-terminal K06282 - 1.12.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005126 548.0
HKD2_k127_8676538_10 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002698 259.0
HKD2_k127_8676538_11 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.000000000000000000000000000000000000000000000000000000000006009 220.0
HKD2_k127_8676538_12 Glycine cleavage H-protein - - - 0.0000000000000000000000000000000000000000000000000007975 205.0
HKD2_k127_8676538_13 glycine decarboxylation via glycine cleavage system K02437 - - 0.00000000000000000000000000000000000000000000003449 183.0
HKD2_k127_8676538_14 Outer membrane receptor - - - 0.000000000000000000000000000000000000000000003541 189.0
HKD2_k127_8676538_15 Hydrogenase maturation protease K03605 - - 0.000000000000000000000000000000000000000000004706 170.0
HKD2_k127_8676538_16 Protein of Unknown function (DUF2784) - - - 0.00000000000000000000000000000000007924 148.0
HKD2_k127_8676538_17 - - - - 0.000000000000000000000000000000001502 132.0
HKD2_k127_8676538_18 B12 binding domain - - - 0.00000000000000000000000000000008287 139.0
HKD2_k127_8676538_19 - - - - 0.00000000000000002218 85.0
HKD2_k127_8676538_2 SMART serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 542.0
HKD2_k127_8676538_20 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.000000000003174 66.0
HKD2_k127_8676538_21 SdpI/YhfL protein family - - - 0.000000007515 61.0
HKD2_k127_8676538_23 B12 binding domain - - - 0.00005724 46.0
HKD2_k127_8676538_24 - - - - 0.0005655 50.0
HKD2_k127_8676538_3 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 466.0
HKD2_k127_8676538_4 PFAM Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 461.0
HKD2_k127_8676538_5 carbon starvation protein CstA K06200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000111 415.0
HKD2_k127_8676538_6 Anion-transporting ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 393.0
HKD2_k127_8676538_7 4Fe-4S dicluster domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 334.0
HKD2_k127_8676538_8 respiratory electron transport chain K03620 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0020037,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0071944,GO:0097159,GO:1901363,GO:1902494 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 325.0
HKD2_k127_8676538_9 Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007468 285.0
HKD2_k127_8684225_0 Carbamoyltransferase C-terminus K00612 - - 1.102e-197 627.0
HKD2_k127_8684225_1 PFAM acyl-CoA dehydrogenase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 437.0
HKD2_k127_8684225_10 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.000000000000000000000000000000000000000000000000002776 210.0
HKD2_k127_8684225_11 PFAM Peptidase M11 gametolysin - - - 0.0000000000000000000000000000000000000000000001745 190.0
HKD2_k127_8684225_12 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000005092 189.0
HKD2_k127_8684225_13 PFAM Polysaccharide export protein - - - 0.000000000000000000000000000000000000000001266 164.0
HKD2_k127_8684225_14 Glycosyltransferase like family 2 K07011 - - 0.00000000000000000000000000000000000000002105 177.0
HKD2_k127_8684225_15 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000001692 169.0
HKD2_k127_8684225_16 Acyltransferase - - - 0.0000000000000000000000000000000000001987 160.0
HKD2_k127_8684225_17 PFAM transferase hexapeptide repeat containing protein K00661 - 2.3.1.79 0.0000000000000000000000000000001969 143.0
HKD2_k127_8684225_18 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000259 134.0
HKD2_k127_8684225_19 alpha-L-arabinofuranosidase K01209 - 3.2.1.55 0.0000000000000000001009 107.0
HKD2_k127_8684225_2 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K13599 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 430.0
HKD2_k127_8684225_20 lipopolysaccharide biosynthesis K20998 - - 0.000000000000000001253 101.0
HKD2_k127_8684225_21 Methyltransferase type 11 - - - 0.000000000000000001754 101.0
HKD2_k127_8684225_22 -O-antigen K03641 - - 0.000000000000000002919 100.0
HKD2_k127_8684225_23 Putative papain-like cysteine peptidase (DUF1796) - - - 0.0000000000003878 79.0
HKD2_k127_8684225_24 polysaccharide deacetylase - - - 0.000000000004967 79.0
HKD2_k127_8684225_25 virulence factor MVIN family protein - - - 0.00000000003029 77.0
HKD2_k127_8684225_26 - - - - 0.0000000001875 64.0
HKD2_k127_8684225_28 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000009804 68.0
HKD2_k127_8684225_29 Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - 0.00000003662 67.0
HKD2_k127_8684225_3 Belongs to the ATP-dependent AMP-binding enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008961 394.0
HKD2_k127_8684225_30 Prolyl oligopeptidase family - - - 0.00003425 56.0
HKD2_k127_8684225_4 PFAM glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 341.0
HKD2_k127_8684225_5 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004421 276.0
HKD2_k127_8684225_6 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000005117 252.0
HKD2_k127_8684225_7 FAD linked oxidase domain protein K00103,K16653 GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010383,GO:0016020,GO:0016051,GO:0031221,GO:0033692,GO:0034637,GO:0034645,GO:0035884,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0070589,GO:0070592,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901576 1.1.3.8,1.1.98.3 0.000000000000000000000000000000000000000000000000000000000000000006568 237.0
HKD2_k127_8684225_8 Alpha-L-arabinofuranosidase K01209 - 3.2.1.55 0.00000000000000000000000000000000000000000000000000002508 216.0
HKD2_k127_8684225_9 sugar transferase - - - 0.0000000000000000000000000000000000000000000000000002224 207.0
HKD2_k127_878266_0 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 609.0
HKD2_k127_878266_1 Belongs to the DegT DnrJ EryC1 family K13010 - 2.6.1.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008799 464.0
HKD2_k127_878266_10 PFAM cytochrome c-type biogenesis protein CcmB K02194 - - 0.0000000000000000000000000000000000000000002915 176.0
HKD2_k127_878266_11 PFAM ABC transporter related K02193 - 3.6.3.41 0.000000000000000000000000000000000000000000744 164.0
HKD2_k127_878266_12 ferredoxin-NADP+ reductase activity - - - 0.0000000000000000000000000000000000001766 151.0
HKD2_k127_878266_13 protein conserved in bacteria K09778 - - 0.00000000000000000000000000000000002562 143.0
HKD2_k127_878266_14 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000000000001864 132.0
HKD2_k127_878266_15 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000005588 116.0
HKD2_k127_878266_16 overlaps another CDS with the same product name - - - 0.000000000000000000002681 111.0
HKD2_k127_878266_17 Belongs to the UPF0102 family K07460 - - 0.0000000000000000001073 100.0
HKD2_k127_878266_18 Glycosyl transferase family group 2 K07011 - - 0.0000000000000001964 94.0
HKD2_k127_878266_19 - - - - 0.0000001279 63.0
HKD2_k127_878266_2 heat shock protein binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 426.0
HKD2_k127_878266_3 threonine dehydratase K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 339.0
HKD2_k127_878266_4 Cytochrome C assembly protein K02198 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 323.0
HKD2_k127_878266_5 polysaccharide biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000279 275.0
HKD2_k127_878266_6 Protein tyrosine kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000006831 243.0
HKD2_k127_878266_7 Cytochrome c assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000001463 222.0
HKD2_k127_878266_8 Oxidoreductase FAD-binding domain - - - 0.00000000000000000000000000000000000000000001566 177.0
HKD2_k127_878266_9 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000001929 183.0
HKD2_k127_8869395_0 GMC oxidoreductase K03333 - 1.1.3.6 4.744e-229 720.0
HKD2_k127_8869395_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005323 572.0
HKD2_k127_8869395_2 PFAM sodium calcium exchanger membrane region K07300 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 423.0
HKD2_k127_8869395_3 Haemolysin-III related K11068 - - 0.0000000000000000000000000000000000000000000000000000000000000000008405 252.0
HKD2_k127_8869395_4 protein of Bacteria UniRef RepID - - - 0.000000000000000000000000000000000000000000000002254 184.0
HKD2_k127_8869395_5 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.00000000000000000000000000000000000007929 149.0
HKD2_k127_8869395_6 Putative adhesin - - - 0.000000001643 70.0
HKD2_k127_890045_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 5.387e-257 807.0
HKD2_k127_890045_1 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 9.018e-214 678.0
HKD2_k127_890045_10 PFAM Type II secretion system F domain K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003559 285.0
HKD2_k127_890045_11 O-methyltransferase K00588 - 2.1.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000005848 266.0
HKD2_k127_890045_12 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001588 248.0
HKD2_k127_890045_13 MoeA N-terminal region (domain I and II) K03750 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006464,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0018315,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0032324,GO:0034641,GO:0036211,GO:0042040,GO:0042278,GO:0042802,GO:0043170,GO:0043412,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061598,GO:0061599,GO:0070566,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.10.1.1 0.000000000000000000000000000000000000000000000000000000000000001471 244.0
HKD2_k127_890045_14 Phosphomethylpyrimidine kinase K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000004053 224.0
HKD2_k127_890045_15 transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.000000000000000000000000000000000000000000000000000000008502 216.0
HKD2_k127_890045_16 PFAM HNH endonuclease - - - 0.00000000000000000000000000000000000000000000000000000002335 208.0
HKD2_k127_890045_17 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.0000000000000000000000000000000000000000000000000000009257 210.0
HKD2_k127_890045_18 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.000000000000000000000000000000000000000000000000006436 199.0
HKD2_k127_890045_19 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000004115 178.0
HKD2_k127_890045_2 PFAM Type II secretion system protein E K02652 - - 2.779e-213 676.0
HKD2_k127_890045_20 - - - - 0.0000000000000000000000000000000000000000001702 184.0
HKD2_k127_890045_21 FAD binding domain - - - 0.000000000000000000000000000000000000000002626 176.0
HKD2_k127_890045_22 Two component regulator propeller - - - 0.00000000000000000000000000000000000000004146 173.0
HKD2_k127_890045_23 microcin C7 resistance K01297 - 3.4.17.13 0.0000000000000000000000000000000000000001005 154.0
HKD2_k127_890045_24 Glycosyltransferase family 9 (heptosyltransferase) K02841 - - 0.000000000000000000000000000003698 132.0
HKD2_k127_890045_25 RNA polymerase sigma factor K03088 - - 0.00000000000000000000000003009 118.0
HKD2_k127_890045_26 nuclear chromosome segregation - - - 0.0000000000000000000000002325 117.0
HKD2_k127_890045_27 DinB superfamily - - - 0.0000000000000000000000009659 119.0
HKD2_k127_890045_28 ECF sigma factor K03088 - - 0.000000000000000000000006824 109.0
HKD2_k127_890045_29 - - - - 0.0000000000000000000001531 102.0
HKD2_k127_890045_3 Acetyl-CoA hydrolase/transferase N-terminal domain - - - 3.327e-213 672.0
HKD2_k127_890045_30 translation initiation factor activity K08086,K20541 - - 0.000000000000000000001165 109.0
HKD2_k127_890045_31 Uncharacterized ACR, COG1430 K09005 - - 0.00000000000000000001426 107.0
HKD2_k127_890045_32 phosphorelay signal transduction system - - - 0.00000000000000000003041 100.0
HKD2_k127_890045_33 type II and III secretion system protein K02453 - - 0.0000000000000000004414 102.0
HKD2_k127_890045_34 - - - - 0.000000000000000005281 94.0
HKD2_k127_890045_35 Methyltransferase domain - - - 0.00000000000000005382 96.0
HKD2_k127_890045_36 Regulatory protein, FmdB family - - - 0.0000000000000005404 82.0
HKD2_k127_890045_37 4-oxalocrotonate tautomerase - - - 0.000000000001163 68.0
HKD2_k127_890045_38 - - - - 0.000000000005741 80.0
HKD2_k127_890045_39 HEAT repeats - - - 0.0000000003527 73.0
HKD2_k127_890045_4 twitching motility protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 514.0
HKD2_k127_890045_40 metallopeptidase activity - - - 0.00000003231 68.0
HKD2_k127_890045_41 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - - 0.00005279 54.0
HKD2_k127_890045_5 PFAM type II secretion system K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007776 454.0
HKD2_k127_890045_6 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006533 454.0
HKD2_k127_890045_7 two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007559 446.0
HKD2_k127_890045_8 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 417.0
HKD2_k127_890045_9 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000001916 283.0
HKD2_k127_8979272_0 PFAM Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004164 418.0
HKD2_k127_8979272_1 cell redox homeostasis K00322 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.6.1.1 0.000000000000000000000004662 114.0
HKD2_k127_8979272_2 NmrA-like family - - - 0.0000001722 53.0
HKD2_k127_8979272_3 ABC transporter K01995 - - 0.000006735 53.0
HKD2_k127_8996138_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005955 269.0
HKD2_k127_8996138_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000003637 242.0
HKD2_k127_8996138_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 0.000000000000003135 78.0
HKD2_k127_9004930_0 Glutamate synthase K00266 - 1.4.1.13,1.4.1.14 4.99e-227 709.0
HKD2_k127_9004930_1 oxidoreductase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000498 454.0
HKD2_k127_9008320_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1752.0
HKD2_k127_9008320_1 - - - - 0.0 1009.0
HKD2_k127_9008320_2 Sortilin, neurotensin receptor 3, - - - 5.06e-210 669.0
HKD2_k127_9008320_3 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001272 502.0
HKD2_k127_9008320_4 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000333 433.0
HKD2_k127_9008320_5 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 439.0
HKD2_k127_9008320_6 DinB family - - - 0.00000000000000000000000000000000000002695 160.0
HKD2_k127_9008320_7 Domain of unknown function (DUF4440) - - - 0.0000000000000000000545 106.0
HKD2_k127_9008320_8 polysaccharide deacetylase - - - 0.00000000000003799 82.0
HKD2_k127_9021792_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007019 346.0
HKD2_k127_9021792_1 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000893 348.0
HKD2_k127_9021792_2 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001746 339.0
HKD2_k127_9021792_3 Biotin-lipoyl like K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 295.0
HKD2_k127_9021792_4 serine-type endopeptidase activity K08372 - - 0.0000000000000000000000000000000000000000000000000000000000000000000193 248.0
HKD2_k127_9021792_5 ABC-type dipeptide transport system periplasmic component K02035,K15580 - - 0.0000000000000000000000000000000000000000001091 185.0
HKD2_k127_9021792_6 cell septum assembly - - - 0.000000000000000000000000000000000006979 151.0
HKD2_k127_9021792_7 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000005171 134.0
HKD2_k127_9021792_8 Disulphide bond corrector protein DsbC - - - 0.000000000003386 74.0
HKD2_k127_906297_0 Involved in the tonB-independent uptake of proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008634 425.0
HKD2_k127_906297_1 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 308.0
HKD2_k127_907109_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000566 470.0
HKD2_k127_907109_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009573 251.0
HKD2_k127_907109_2 ABC-2 type transporter K09690 - - 0.0000000000000000000000000000001123 141.0
HKD2_k127_907109_3 Helix-turn-helix - - - 0.00000007819 61.0
HKD2_k127_907109_4 FG-GAP repeat - - - 0.000001134 62.0
HKD2_k127_9072148_0 Cupin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001488 315.0
HKD2_k127_9072148_1 PFAM binding-protein-dependent transport systems inner membrane component K02033,K12369,K13890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 297.0
HKD2_k127_9072148_2 Transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003388 269.0
HKD2_k127_9072148_3 ubiE/COQ5 methyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000002412 244.0
HKD2_k127_9072148_4 COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0000000000000000000000000000000000000000000000000000002663 214.0
HKD2_k127_9072148_5 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000001817 170.0
HKD2_k127_9120747_0 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005418 364.0
HKD2_k127_9120747_1 GlcNAc-PI de-N-acetylase - - - 0.00000000000000000000000000000000000000000000000000000000000002333 226.0
HKD2_k127_9145701_0 PFAM DAHP synthetase I KDSA K03856,K04518,K14170 GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.5.1.54,4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003931 454.0
HKD2_k127_9145701_1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005402 333.0
HKD2_k127_9145701_10 Alpha beta hydrolase - - - 0.000000000000000000194 98.0
HKD2_k127_9145701_11 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000001385 101.0
HKD2_k127_9145701_12 Protein of unknown function, DUF547 - - - 0.00000000000000001147 97.0
HKD2_k127_9145701_13 - - - - 0.0000000007253 70.0
HKD2_k127_9145701_14 Sporulation and spore germination K06298 - - 0.0001184 53.0
HKD2_k127_9145701_2 TIGRFAM amidohydrolase K12941 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 352.0
HKD2_k127_9145701_3 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004128 282.0
HKD2_k127_9145701_4 synthase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001667 277.0
HKD2_k127_9145701_5 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000004913 240.0
HKD2_k127_9145701_6 Homocysteine S-methyltransferase K00547 - 2.1.1.10 0.0000000000000000000000000000000000000000000000000000000001371 214.0
HKD2_k127_9145701_7 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000001203 203.0
HKD2_k127_9145701_8 oxidoreductase activity K12511 - - 0.000000000000000000000000000000002324 148.0
HKD2_k127_9145701_9 cell septum assembly - - - 0.00000000000000000000000000000001136 139.0
HKD2_k127_9159668_0 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009806 348.0
HKD2_k127_9159668_1 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005423 299.0
HKD2_k127_9159668_2 Metallo-peptidase family M12 - - - 0.000000000000000000000000000000000001154 160.0
HKD2_k127_9159668_3 helix_turn_helix, Arsenical Resistance Operon Repressor K03892,K21903 - - 0.000000000000000000000000002366 114.0
HKD2_k127_9159668_8 Hypothetical methyltransferase K07755 - 2.1.1.137 0.0000001812 54.0
HKD2_k127_9181424_0 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 551.0
HKD2_k127_9181424_1 Translation elongation factor P EF-P - - - 0.000000000000000000000000000000000000000000004663 168.0
HKD2_k127_9283207_0 Belongs to the glycosyl hydrolase 13 family - - - 0.0 1024.0
HKD2_k127_9283207_1 PFAM Sulfate transporter antisigma-factor antagonist STAS - - - 1.216e-248 777.0
HKD2_k127_9283207_10 cheY-homologous receiver domain - - - 0.000000000000000000000000000001327 126.0
HKD2_k127_9283207_11 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000002247 126.0
HKD2_k127_9283207_12 - - - - 0.00000000000000000003019 106.0
HKD2_k127_9283207_2 Fumarase C C-terminus K01744 - 4.3.1.1 7.769e-210 661.0
HKD2_k127_9283207_3 Inorganic ion transport and metabolism K03319 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003685 508.0
HKD2_k127_9283207_4 Predicted Permease Membrane Region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003962 339.0
HKD2_k127_9283207_5 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase K03796 - - 0.0000000000000000000000000000000000000000000000000000000000000001016 233.0
HKD2_k127_9283207_6 Belongs to the 5'-nucleotidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000001938 234.0
HKD2_k127_9283207_7 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000009594 223.0
HKD2_k127_9283207_8 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000002555 214.0
HKD2_k127_9283207_9 SMART ATP-binding region, ATPase-like - - - 0.0000000000000000000000000000000000000000001176 181.0
HKD2_k127_9448059_0 Probably functions as a manganese efflux pump - - - 0.00000000000000000000000000000000000000000001644 184.0
HKD2_k127_9448059_1 - - - - 0.000000000000000000001452 110.0
HKD2_k127_9448059_2 membrane - - - 0.0002346 53.0
HKD2_k127_9477885_0 magnesium chelatase K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 544.0
HKD2_k127_9477885_1 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000562 400.0
HKD2_k127_9477885_2 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000009565 139.0
HKD2_k127_9477885_3 peroxiredoxin activity - - - 0.000000000000000001499 92.0
HKD2_k127_9478925_0 DNA RNA helicase, superfamily II, SNF2 family K08282 - 2.7.11.1 1.016e-216 712.0
HKD2_k127_9478925_1 cyclic 2,3-diphosphoglycerate synthetase activity - - - 2.085e-207 653.0
HKD2_k127_9478925_10 4 iron, 4 sulfur cluster binding K00113,K00176,K05524,K13795,K13796 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 351.0
HKD2_k127_9478925_11 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006307 332.0
HKD2_k127_9478925_12 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 335.0
HKD2_k127_9478925_13 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K01810,K13810 - 2.2.1.2,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005942 323.0
HKD2_k127_9478925_14 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004015 287.0
HKD2_k127_9478925_15 Fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006582 286.0
HKD2_k127_9478925_16 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009422 308.0
HKD2_k127_9478925_17 PFAM Peptidase family M20 M25 M40 K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004723 306.0
HKD2_k127_9478925_18 Peroxiredoxin K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000199 264.0
HKD2_k127_9478925_19 Rubrerythrin - GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.00000000000000000000000000000000000000000000000000000000000000000000009121 241.0
HKD2_k127_9478925_2 Belongs to the transketolase family K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008443 603.0
HKD2_k127_9478925_20 Histidinol phosphate phosphatase, HisJ family K04486 - 3.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000003255 233.0
HKD2_k127_9478925_21 Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.000000000000000000000000000000000000000000000000000000000001673 217.0
HKD2_k127_9478925_22 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000005536 214.0
HKD2_k127_9478925_23 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000001016 226.0
HKD2_k127_9478925_24 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000002169 222.0
HKD2_k127_9478925_25 Transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000006674 217.0
HKD2_k127_9478925_26 Polysaccharide lyase family 4, domain II - - - 0.0000000000000000000000000000000000000000000000000000001338 204.0
HKD2_k127_9478925_27 peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000000000000001219 189.0
HKD2_k127_9478925_28 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000006447 205.0
HKD2_k127_9478925_29 Protein of unknown function (DUF2400) - - - 0.00000000000000000000000000000000000000000000000009293 193.0
HKD2_k127_9478925_3 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 595.0
HKD2_k127_9478925_30 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.000000000000000000000000000000000000000000001806 177.0
HKD2_k127_9478925_31 TPM domain K06872 - - 0.000000000000000000000000000000000000000000008237 175.0
HKD2_k127_9478925_32 Histidine kinase - - - 0.000000000000000000000000000000000000000003996 166.0
HKD2_k127_9478925_33 Outer membrane protein protective antigen OMA87 - - - 0.0000000000000000000000000000000000000002162 169.0
HKD2_k127_9478925_34 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000006441 166.0
HKD2_k127_9478925_35 lactate metabolic process - - - 0.0000000000000000000000000000000000003152 160.0
HKD2_k127_9478925_36 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.00000000000000000000000000000000004542 139.0
HKD2_k127_9478925_37 SCO1/SenC K07152,K08976 - - 0.0000000000000000000000000000000000863 151.0
HKD2_k127_9478925_38 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000000001379 134.0
HKD2_k127_9478925_39 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.0000000000000000000000000000000002168 151.0
HKD2_k127_9478925_4 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 449.0
HKD2_k127_9478925_40 Protein of unknown function (DUF420) - - - 0.0000000000000000000000000000000004101 146.0
HKD2_k127_9478925_41 synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000001981 118.0
HKD2_k127_9478925_42 Ribosomal prokaryotic L21 protein K02888 - - 0.00000000000000000000000005109 110.0
HKD2_k127_9478925_43 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000002417 117.0
HKD2_k127_9478925_44 Binds the 23S rRNA K02909 - - 0.000000000000000000000004324 106.0
HKD2_k127_9478925_45 Hpt domain - - - 0.000000000000000000000007504 117.0
HKD2_k127_9478925_46 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.00000000000000000000001046 115.0
HKD2_k127_9478925_47 TPM domain - - - 0.00000000000000000000002096 113.0
HKD2_k127_9478925_48 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.0000000000000000000002614 100.0
HKD2_k127_9478925_49 Transglycosylase SLT domain K08309 - - 0.0000000000000000009287 102.0
HKD2_k127_9478925_5 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 430.0
HKD2_k127_9478925_50 SWIM zinc finger - - - 0.00000000000000001419 96.0
HKD2_k127_9478925_51 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.0000000000000003752 92.0
HKD2_k127_9478925_52 - - - - 0.00000000000000266 79.0
HKD2_k127_9478925_53 - - - - 0.000000000000746 80.0
HKD2_k127_9478925_54 Phosphoglycerate mutase family K08296 - - 0.0000000000009554 78.0
HKD2_k127_9478925_55 - - - - 0.0000003106 59.0
HKD2_k127_9478925_6 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 411.0
HKD2_k127_9478925_7 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003862 408.0
HKD2_k127_9478925_8 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 371.0
HKD2_k127_9478925_9 GTP1/OBG K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003655 356.0
HKD2_k127_9528308_0 Dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008584 387.0
HKD2_k127_9528308_1 Cysteine dioxygenase type I - - - 0.00000000001018 74.0
HKD2_k127_953784_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1060.0
HKD2_k127_953784_1 Heat shock 70 kDa protein K04043 - - 6.44e-216 686.0
HKD2_k127_953784_10 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000000000000001638 201.0
HKD2_k127_953784_11 Peptidase family M23 - - - 0.000000000000000000000000000000000000000001194 167.0
HKD2_k127_953784_12 CarD-like/TRCF domain K07736 - - 0.000000000000000000000000000000000000002211 154.0
HKD2_k127_953784_13 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.0000000000000000000000000004126 131.0
HKD2_k127_953784_14 Tetratricopeptide repeat - - - 0.00000000000000000000002462 111.0
HKD2_k127_953784_15 VanZ like family - - - 0.0004963 53.0
HKD2_k127_953784_2 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.39e-199 631.0
HKD2_k127_953784_3 PFAM magnesium chelatase ChlI subunit K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 505.0
HKD2_k127_953784_4 Recombination factor protein RarA K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009667 488.0
HKD2_k127_953784_5 L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000276 266.0
HKD2_k127_953784_6 GTP binding K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004623 270.0
HKD2_k127_953784_7 Lytic transglycosylase, SLT, LysM and LysM domain-containing K08307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007393 259.0
HKD2_k127_953784_8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000002598 236.0
HKD2_k127_953784_9 MgtE intracellular N domain - - - 0.000000000000000000000000000000000000000000000000000002338 212.0
HKD2_k127_9555297_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000001124 278.0
HKD2_k127_9555297_1 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765,K02502 - 2.4.2.17 0.000000000000000000000000000000000000000000003126 186.0
HKD2_k127_9555297_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769 2.6.1.9 0.0000000000166 77.0
HKD2_k127_9555297_3 Shikimate dehydrogenase substrate binding domain K00014 - 1.1.1.25 0.00000000009656 67.0
HKD2_k127_960064_0 Involved in the tonB-independent uptake of proteins - - - 6.174e-205 684.0
HKD2_k127_960064_1 PFAM Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008595 512.0
HKD2_k127_960064_10 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 393.0
HKD2_k127_960064_11 Glycosyl transferase family 2 K10012,K20534 - 2.4.2.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006147 381.0
HKD2_k127_960064_12 ATPases associated with a variety of cellular activities K01990,K09689,K09691,K09693 - 3.6.3.38,3.6.3.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006597 391.0
HKD2_k127_960064_13 COG0500 SAM-dependent methyltransferases K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001983 368.0
HKD2_k127_960064_14 metallocarboxypeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000112 379.0
HKD2_k127_960064_15 3-demethylubiquinone-9 3-O-methyltransferase activity K07011,K20444 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 373.0
HKD2_k127_960064_16 Penicillin amidase K01434 - 3.5.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 374.0
HKD2_k127_960064_17 L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 334.0
HKD2_k127_960064_18 Integrin alpha (beta-propellor repeats). - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002147 331.0
HKD2_k127_960064_19 Formyl transferase, C-terminal domain K00604 - 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001319 313.0
HKD2_k127_960064_2 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 525.0
HKD2_k127_960064_20 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001408 276.0
HKD2_k127_960064_21 Lipocalin-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005156 303.0
HKD2_k127_960064_22 Spermine/spermidine synthase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001686 276.0
HKD2_k127_960064_23 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001007 254.0
HKD2_k127_960064_24 PFAM glycosyl transferase family 39 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002143 268.0
HKD2_k127_960064_25 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000003581 261.0
HKD2_k127_960064_26 PFAM NADP oxidoreductase coenzyme F420-dependent K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000001695 248.0
HKD2_k127_960064_27 Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000005889 239.0
HKD2_k127_960064_29 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000004582 212.0
HKD2_k127_960064_3 COG0798 Arsenite efflux pump ACR3 and related K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 492.0
HKD2_k127_960064_30 ABC-2 type transporter K09690 - - 0.00000000000000000000000000000000000000000000000000000000006708 215.0
HKD2_k127_960064_31 Methyltransferase FkbM domain - - - 0.0000000000000000000000000000000000000000000000000000000002411 213.0
HKD2_k127_960064_32 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000151 201.0
HKD2_k127_960064_33 NAD dependent epimerase/dehydratase family - - - 0.000000000000000000000000000000000000000000000000003223 191.0
HKD2_k127_960064_34 SOUL heme-binding protein - - - 0.00000000000000000000000000000000000000000000001712 179.0
HKD2_k127_960064_35 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.000000000000000000000000000000000000000000001852 173.0
HKD2_k127_960064_36 PFAM glycosyl transferase family 39 K14340 - - 0.000000000000000000000000000000000000000000002835 189.0
HKD2_k127_960064_37 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000004065 184.0
HKD2_k127_960064_38 ECF sigma factor - - - 0.00000000000000000000000000000000000000000009217 166.0
HKD2_k127_960064_39 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000242 168.0
HKD2_k127_960064_4 Carboxypeptidase regulatory-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000012 520.0
HKD2_k127_960064_40 Cellulose biosynthesis protein BcsQ K03496 - - 0.0000000000000000000000000000000000000005736 158.0
HKD2_k127_960064_41 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03635,K21142 - 2.8.1.12 0.0000000000000000000000000000000000006635 149.0
HKD2_k127_960064_42 PFAM Peptidase M20 - - - 0.000000000000000000000000000000000001616 161.0
HKD2_k127_960064_43 beta-lactamase K17836 - 3.5.2.6 0.000000000000000000000000000000000006874 147.0
HKD2_k127_960064_44 Haloacid dehalogenase-like hydrolase K07025 - - 0.000000000000000000000000000005108 137.0
HKD2_k127_960064_45 TonB C terminal K03832 - - 0.0000000000000000000000000006838 117.0
HKD2_k127_960064_46 OsmC-like protein - - - 0.000000000000000000000000011 113.0
HKD2_k127_960064_47 helix_turn_helix, Arsenical Resistance Operon Repressor K03892,K21903 - - 0.0000000000000000000000000133 113.0
HKD2_k127_960064_48 Bacterial membrane protein, YfhO - - - 0.00000000000000000000000068 122.0
HKD2_k127_960064_49 Transcriptional regulator K07735 - - 0.0000000000000000000000008451 113.0
HKD2_k127_960064_5 surface antigen variable number repeat protein K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004039 474.0
HKD2_k127_960064_50 SMART protein phosphatase 2C domain protein K07315 - 3.1.3.3 0.00000000000000000000002947 117.0
HKD2_k127_960064_51 oligosaccharyl transferase activity K07151 - 2.4.99.18 0.00000000000000000001588 109.0
HKD2_k127_960064_52 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000003285 90.0
HKD2_k127_960064_53 Bacterial membrane protein, YfhO - - - 0.000000000000006197 90.0
HKD2_k127_960064_54 retrograde transport, endosome to Golgi K07095 - - 0.00000000000003207 83.0
HKD2_k127_960064_55 Belongs to the peptidase S8 family - - - 0.0000000000000469 87.0
HKD2_k127_960064_56 dipeptidyl-peptidase activity - - - 0.0000000000003495 83.0
HKD2_k127_960064_57 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03635,K21142 - 2.8.1.12 0.0000000000004809 71.0
HKD2_k127_960064_58 Psort location CytoplasmicMembrane, score - - - 0.000000000171 76.0
HKD2_k127_960064_59 SNARE associated Golgi protein K03975 - - 0.000000006681 57.0
HKD2_k127_960064_6 lipoprotein localization to outer membrane K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 487.0
HKD2_k127_960064_60 Belongs to the ArsC family - - - 0.000002943 53.0
HKD2_k127_960064_61 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00008585 53.0
HKD2_k127_960064_62 DinB family - - - 0.0002596 52.0
HKD2_k127_960064_63 SprT-like family - - - 0.000868 52.0
HKD2_k127_960064_7 3-beta hydroxysteroid dehydrogenase/isomerase family K10011,K12449 - 1.1.1.305,2.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 464.0
HKD2_k127_960064_8 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008476 435.0
HKD2_k127_960064_9 Predicted permease K07089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 408.0
HKD2_k127_9617151_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 2.19e-229 731.0
HKD2_k127_9617151_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008835 431.0
HKD2_k127_9617151_10 ATPase involved in DNA repair - - - 0.0000003158 61.0
HKD2_k127_9617151_2 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K11102 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 359.0
HKD2_k127_9617151_3 TIGRFAM type IV pilus assembly protein PilM K02662 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008088 340.0
HKD2_k127_9617151_4 Secretin and TonB N terminus short domain K02666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 316.0
HKD2_k127_9617151_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002215 288.0
HKD2_k127_9617151_6 SNARE associated Golgi protein K03975 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006628 283.0
HKD2_k127_9617151_7 Pilus assembly protein, PilO K02664 - - 0.000000000000000000000001045 114.0
HKD2_k127_9617151_8 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000002545 83.0
HKD2_k127_9617151_9 PFAM Fimbrial assembly family protein K02663 - - 0.000000002231 70.0
HKD2_k127_9633242_0 FAD linked oxidases, C-terminal domain K18930 - - 0.0 1123.0
HKD2_k127_9633242_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009678 399.0
HKD2_k127_9633242_2 Belongs to the glycosyl hydrolase 57 family K16149 - 2.4.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 401.0
HKD2_k127_9633242_3 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.000000000000000000000000000000000000000000000000001574 188.0
HKD2_k127_9633242_4 Transcription factor zinc-finger - - - 0.00000000000000000000000000000003648 140.0
HKD2_k127_9633242_5 COG3209 Rhs family protein - - - 0.000003922 57.0
HKD2_k127_9648788_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1469.0
HKD2_k127_9648788_1 NapC/NirT cytochrome c family, N-terminal region - - - 1.433e-194 617.0
HKD2_k127_9648788_10 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004825 405.0
HKD2_k127_9648788_11 Membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 389.0
HKD2_k127_9648788_12 Insulinase (Peptidase family M16) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004918 369.0
HKD2_k127_9648788_13 formate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001596 321.0
HKD2_k127_9648788_14 Outer membrane efflux protein K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002378 316.0
HKD2_k127_9648788_15 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001094 286.0
HKD2_k127_9648788_16 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000001592 270.0
HKD2_k127_9648788_17 PFAM Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001021 279.0
HKD2_k127_9648788_18 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008946 259.0
HKD2_k127_9648788_19 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000105 258.0
HKD2_k127_9648788_2 Zinc carboxypeptidase K14054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004791 537.0
HKD2_k127_9648788_20 Pfam:Methyltransf_6 - - - 0.00000000000000000000000000000000000000000000000000000000000000001008 253.0
HKD2_k127_9648788_21 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000006387 225.0
HKD2_k127_9648788_22 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000001803 188.0
HKD2_k127_9648788_23 OsmC-like protein K04063 - - 0.00000000000000000000000000000000000000000003738 167.0
HKD2_k127_9648788_24 Protein of unknown function (DUF1579) - - - 0.00000000000000000000000000000000000000004173 160.0
HKD2_k127_9648788_25 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000001352 146.0
HKD2_k127_9648788_26 PFAM pyridoxamine 5'-phosphate oxidase-related, FMN-binding K07226 - - 0.00000000000000000000000000002108 123.0
HKD2_k127_9648788_27 Pas domain - - - 0.000000000000000000001431 103.0
HKD2_k127_9648788_28 addiction module antidote protein HigA K21498 - - 0.00000000000000003157 85.0
HKD2_k127_9648788_29 PFAM Phosphate-selective porin O and P - - - 0.0000000000000009069 90.0
HKD2_k127_9648788_3 Protein of unknown function (DUF2891) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004663 488.0
HKD2_k127_9648788_31 AMP-binding enzyme C-terminal domain K18660,K18661 - - 0.0001992 49.0
HKD2_k127_9648788_4 Peptidase, M16 K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004024 493.0
HKD2_k127_9648788_5 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 497.0
HKD2_k127_9648788_6 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006674 474.0
HKD2_k127_9648788_7 Amidohydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008781 471.0
HKD2_k127_9648788_8 PFAM ATP-binding region, ATPase domain protein domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009427 446.0
HKD2_k127_9648788_9 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 435.0
HKD2_k127_9665085_0 Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 8.295e-247 790.0
HKD2_k127_9665085_1 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003657 417.0
HKD2_k127_9665085_2 Hemolysin-type calcium-binding repeat (2 copies) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006625 347.0
HKD2_k127_9665085_3 HxlR-like helix-turn-helix - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000162 256.0
HKD2_k127_9665085_4 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000000000000000000000000000000001386 237.0
HKD2_k127_9665085_5 PFAM 2Fe-2S -binding K03518,K07302,K13483 - 1.2.5.3,1.3.99.16 0.00000000000000000000000000000000000000000000000000000000001513 212.0
HKD2_k127_9665085_6 deoxyhypusine monooxygenase activity K01256 - 3.4.11.2 0.0000000000000000000000000000000000000000000000000005224 197.0
HKD2_k127_9665085_7 DinB superfamily - - - 0.0000000000000000000000000000000000000000000000000006023 209.0
HKD2_k127_9691585_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 2.038e-194 625.0
HKD2_k127_9691585_1 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 556.0
HKD2_k127_9691585_11 Protein of unknown function (DUF1003) - - - 0.000000000000000000000000000000000000000000000000000000000000000000004296 244.0
HKD2_k127_9691585_12 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000005433 234.0
HKD2_k127_9691585_13 tRNA pseudouridine synthase K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000002408 239.0
HKD2_k127_9691585_14 protein and some similarities with VgrG protein - - - 0.00000000000000000000000000000000000000000000000000000000000001807 226.0
HKD2_k127_9691585_15 polysaccharide deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000001227 214.0
HKD2_k127_9691585_16 light absorption - - - 0.00000000000000000000000000000000000000000000000001927 196.0
HKD2_k127_9691585_17 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.0000000000000000000000000000000000000000000000000202 198.0
HKD2_k127_9691585_18 Cupin domain - - - 0.0000000000000000000000000000000000000000000002095 171.0
HKD2_k127_9691585_19 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000001805 164.0
HKD2_k127_9691585_2 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 531.0
HKD2_k127_9691585_20 GDP-mannose mannosyl hydrolase activity - - - 0.000000000000000000000000000000000002815 149.0
HKD2_k127_9691585_21 Glycosyl transferase, family 2 K07011 - - 0.00000000000000000000000000000000006065 145.0
HKD2_k127_9691585_22 Stage II sporulation protein E (SpoIIE) K07315 - 3.1.3.3 0.000000000000000000000000000000006268 132.0
HKD2_k127_9691585_23 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000008342 115.0
HKD2_k127_9691585_24 Protein of unknown function, DUF255 - - - 0.000000000000000000001345 109.0
HKD2_k127_9691585_25 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.0000000000000009369 92.0
HKD2_k127_9691585_26 - - - - 0.000000000000005657 81.0
HKD2_k127_9691585_27 Virulence activator alpha C-term - - - 0.0000000000009008 77.0
HKD2_k127_9691585_28 organic hydroperoxide resistance protein - - - 0.000000007162 63.0
HKD2_k127_9691585_29 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon - - - 0.0000001809 64.0
HKD2_k127_9691585_3 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 502.0
HKD2_k127_9691585_31 glycosyl transferase family 39 - - - 0.00007718 55.0
HKD2_k127_9691585_32 Tetratricopeptide repeat - - - 0.0001843 52.0
HKD2_k127_9691585_4 Aldehyde dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008514 477.0
HKD2_k127_9691585_5 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 416.0
HKD2_k127_9691585_6 Sugar transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006594 375.0
HKD2_k127_9691585_7 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 382.0
HKD2_k127_9691585_8 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009593 343.0
HKD2_k127_9691585_9 Domain of unknown function (DUF1972) K12996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007472 344.0
HKD2_k127_9705913_0 Glycogen debranching enzyme - - - 0.0 1270.0
HKD2_k127_9705913_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 8.24e-246 799.0
HKD2_k127_9705913_10 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 382.0
HKD2_k127_9705913_11 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007174 397.0
HKD2_k127_9705913_12 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004748 374.0
HKD2_k127_9705913_13 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001333 366.0
HKD2_k127_9705913_14 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 328.0
HKD2_k127_9705913_15 Ni2 binding GTPase involved in regulation of expression and maturation of urease and hydrogenase K04652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 312.0
HKD2_k127_9705913_16 Belongs to the SEDS family K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004471 303.0
HKD2_k127_9705913_17 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008427 279.0
HKD2_k127_9705913_18 Mechanosensitive ion channel K16052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001507 279.0
HKD2_k127_9705913_19 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000006092 269.0
HKD2_k127_9705913_2 Belongs to the heat shock protein 70 family - - - 3.853e-195 619.0
HKD2_k127_9705913_20 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000476 239.0
HKD2_k127_9705913_21 DNA polymerase III subunit epsilon K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000007131 226.0
HKD2_k127_9705913_22 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000001676 220.0
HKD2_k127_9705913_23 Hep Hag repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000008979 222.0
HKD2_k127_9705913_24 sulfuric ester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000901 218.0
HKD2_k127_9705913_25 PFAM ABC transporter K01990 - - 0.000000000000000000000000000000000000002665 151.0
HKD2_k127_9705913_26 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000000000001312 144.0
HKD2_k127_9705913_27 SurA N-terminal domain K03771 - 5.2.1.8 0.00000000000000000000000000002397 134.0
HKD2_k127_9705913_28 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000005618 121.0
HKD2_k127_9705913_29 Domain of unknown function (DUF4920) - - - 0.0000000000000000000000000212 113.0
HKD2_k127_9705913_3 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001473 566.0
HKD2_k127_9705913_30 SMART protein phosphatase 2C domain protein K07315 - 3.1.3.3 0.0000000000000000000000000643 127.0
HKD2_k127_9705913_31 Responsible for synthesis of pseudouridine from uracil K06179,K06180 - 5.4.99.23,5.4.99.24 0.000000000000000000000004475 114.0
HKD2_k127_9705913_32 TonB-dependent receptor plug - - - 0.000000000000000000002219 111.0
HKD2_k127_9705913_33 polysaccharide deacetylase - - - 0.00000000002928 76.0
HKD2_k127_9705913_34 PQ loop repeat K15383 - - 0.0000000002799 64.0
HKD2_k127_9705913_35 peptidylprolyl isomerase K03770 - 5.2.1.8 0.000008791 60.0
HKD2_k127_9705913_36 Cell division protein FtsQ K03589 - - 0.00001713 58.0
HKD2_k127_9705913_37 Glycosyltransferase family 87 K13671 - - 0.0001028 56.0
HKD2_k127_9705913_38 Evidence 5 No homology to any previously reported sequences - - - 0.0001325 51.0
HKD2_k127_9705913_4 radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 537.0
HKD2_k127_9705913_5 Belongs to the MurCDEF family K01924 GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 484.0
HKD2_k127_9705913_6 Site-specific recombinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003286 466.0
HKD2_k127_9705913_7 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 439.0
HKD2_k127_9705913_8 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009237 441.0
HKD2_k127_9705913_9 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 385.0
HKD2_k127_9803219_0 arylsulfatase A K01130 - 3.1.6.1 3.807e-288 891.0
HKD2_k127_9803219_1 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 559.0
HKD2_k127_9803219_10 ABC transporter substrate-binding protein PnrA-like K07335 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008756 295.0
HKD2_k127_9803219_11 ABC transporter related K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000006396 213.0
HKD2_k127_9803219_12 sigma factor antagonist activity K04757,K17752 - 2.7.11.1 0.000000000000000000000000000000000000000003391 160.0
HKD2_k127_9803219_13 KR domain K03793 - 1.5.1.33 0.00000000000000000000000000000000000000002421 163.0
HKD2_k127_9803219_14 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000163 158.0
HKD2_k127_9803219_15 Redoxin K03564 - 1.11.1.15 0.0000000000000000000000000000000000001352 164.0
HKD2_k127_9803219_16 Bacterial regulatory proteins, tetR family K13770 - - 0.000000000000000000000000000000000001293 147.0
HKD2_k127_9803219_17 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.000000000000000000000000000000005093 149.0
HKD2_k127_9803219_18 Domain of unknown function (DUF4833) - - - 0.0000000000007071 81.0
HKD2_k127_9803219_19 Domain of unknown function (DUF4136) - - - 0.0000002025 60.0
HKD2_k127_9803219_2 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008832 511.0
HKD2_k127_9803219_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000296 511.0
HKD2_k127_9803219_4 Phosphotransfer between the C1 and C5 carbon atoms of pentose K01839 - 5.4.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004715 436.0
HKD2_k127_9803219_5 Belongs to the carbamate kinase family K00926 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.7.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 420.0
HKD2_k127_9803219_6 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 411.0
HKD2_k127_9803219_7 Protein tyrosine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 362.0
HKD2_k127_9803219_8 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002349 321.0
HKD2_k127_9803219_9 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009756 317.0
HKD2_k127_9823114_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1055.0
HKD2_k127_9823114_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 4.32e-308 955.0
HKD2_k127_9823114_10 Pirin K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002723 341.0
HKD2_k127_9823114_11 belongs to the aldehyde dehydrogenase family K22445 - 1.2.99.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 342.0
HKD2_k127_9823114_12 Male sterility protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009506 331.0
HKD2_k127_9823114_13 PFAM PfkB domain protein K00856 - 2.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006652 325.0
HKD2_k127_9823114_14 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001368 324.0
HKD2_k127_9823114_15 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006797 316.0
HKD2_k127_9823114_16 CBS domain K04767 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001305 273.0
HKD2_k127_9823114_17 Protein of unknown function (DUF1295) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008348 269.0
HKD2_k127_9823114_18 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007471 266.0
HKD2_k127_9823114_19 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004294 282.0
HKD2_k127_9823114_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 3.47e-246 827.0
HKD2_k127_9823114_20 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000000000002846 253.0
HKD2_k127_9823114_21 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.00000000000000000000000000000000000000000000000000000000000000000028 249.0
HKD2_k127_9823114_22 Anthranilate synthase component I K01657,K01665,K13950 - 2.6.1.85,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000002712 232.0
HKD2_k127_9823114_23 SpoIVB peptidase S55 - - - 0.000000000000000000000000000000000000000000000000000000004656 223.0
HKD2_k127_9823114_24 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000000000000000000001165 209.0
HKD2_k127_9823114_25 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000000000000000000000000000000000000000000003245 197.0
HKD2_k127_9823114_26 EXOIII K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000003333 212.0
HKD2_k127_9823114_27 MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000000000000000000000000000000001004 196.0
HKD2_k127_9823114_28 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000005974 185.0
HKD2_k127_9823114_29 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000001183 201.0
HKD2_k127_9823114_3 Sugar (and other) transporter - - - 2.768e-245 767.0
HKD2_k127_9823114_30 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033,K15581 - - 0.00000000000000000000000000000000000000000000000003512 190.0
HKD2_k127_9823114_31 Domain of unknown function (DUF4212) - - - 0.000000000000000000000000000000000009825 138.0
HKD2_k127_9823114_32 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000003628 144.0
HKD2_k127_9823114_33 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000000000003529 134.0
HKD2_k127_9823114_34 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000006047 136.0
HKD2_k127_9823114_35 PFAM Biopolymer transport protein ExbD TolR K03560 - - 0.000000000000000000000000001198 117.0
HKD2_k127_9823114_36 PFAM thioesterase superfamily K07107 - - 0.000000000000000000000000001641 117.0
HKD2_k127_9823114_37 Polymer-forming cytoskeletal - - - 0.0000000000000000000000001845 111.0
HKD2_k127_9823114_38 Outer membrane lipoprotein - - - 0.00000000000000000000001523 110.0
HKD2_k127_9823114_39 short chain amide porin - - - 0.00000000000000000001018 105.0
HKD2_k127_9823114_4 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 2.999e-234 759.0
HKD2_k127_9823114_40 Methyltransferase, chemotaxis proteins - - - 0.0000000000000000000907 106.0
HKD2_k127_9823114_41 Universal stress protein family - - - 0.0000000000000006043 85.0
HKD2_k127_9823114_42 Lipopolysaccharide-assembly - - - 0.00000000000001395 89.0
HKD2_k127_9823114_43 TIGRFAM TonB family K03832 - - 0.0000000003614 72.0
HKD2_k127_9823114_44 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00826,K02619 - 2.6.1.42,4.1.3.38 0.00000007173 63.0
HKD2_k127_9823114_45 Binds directly to 16S ribosomal RNA K02968 - - 0.0000002055 58.0
HKD2_k127_9823114_46 cheY-homologous receiver domain K03413 - - 0.00002146 57.0
HKD2_k127_9823114_5 Belongs to the aldehyde dehydrogenase family K22187 - - 3.696e-220 696.0
HKD2_k127_9823114_6 CBS domain containing protein K07182 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006266 595.0
HKD2_k127_9823114_7 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005501 541.0
HKD2_k127_9823114_8 including yeast histone deacetylase and acetoin utilization protein K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002965 471.0
HKD2_k127_9823114_9 Aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005952 424.0
HKD2_k127_9876158_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 599.0
HKD2_k127_9876158_1 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005679 567.0
HKD2_k127_9876158_2 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000842 490.0
HKD2_k127_9876158_3 COG2939 Carboxypeptidase C (cathepsin A) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005349 471.0
HKD2_k127_9876158_4 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006842 469.0
HKD2_k127_9876158_5 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003387 436.0
HKD2_k127_9876158_6 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009062 406.0
HKD2_k127_9876158_7 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007875 331.0
HKD2_k127_9876158_8 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000002341 226.0
HKD2_k127_9876158_9 - - - - 0.0000009203 57.0
HKD2_k127_9943177_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1256.0
HKD2_k127_9943177_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1164.0
HKD2_k127_9943177_10 FAD dependent oxidoreductase - - - 2.537e-214 678.0
HKD2_k127_9943177_100 Membrane - - - 0.0000000000000002666 93.0
HKD2_k127_9943177_101 PFAM 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.0000000000000003239 83.0
HKD2_k127_9943177_103 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000005341 89.0
HKD2_k127_9943177_104 STAS domain K04749 - - 0.000000000000006211 79.0
HKD2_k127_9943177_105 - - - - 0.0000000000001227 84.0
HKD2_k127_9943177_106 Flagellar rod assembly protein muramidase FlgJ - - - 0.000000000001589 81.0
HKD2_k127_9943177_107 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.0000000002403 67.0
HKD2_k127_9943177_108 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.000000003992 66.0
HKD2_k127_9943177_109 VanZ like family - - - 0.000000006495 69.0
HKD2_k127_9943177_11 Domain of Unknown Function (DUF748) - - - 2.894e-203 677.0
HKD2_k127_9943177_110 Uncharacterised protein family (UPF0227) K07000 - - 0.0000003254 62.0
HKD2_k127_9943177_111 PFAM helix-turn-helix, Fis-type - - - 0.0000009727 54.0
HKD2_k127_9943177_112 transcriptional regulator - - - 0.000001342 55.0
HKD2_k127_9943177_113 - - - - 0.000003081 61.0
HKD2_k127_9943177_114 belongs to the thioredoxin family - - - 0.000034 54.0
HKD2_k127_9943177_115 - - - - 0.0002456 48.0
HKD2_k127_9943177_116 LysM domain - - - 0.0007426 51.0
HKD2_k127_9943177_12 Belongs to the aldehyde dehydrogenase family K00294 - 1.2.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005866 606.0
HKD2_k127_9943177_13 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003557 605.0
HKD2_k127_9943177_14 Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 599.0
HKD2_k127_9943177_15 PFAM NAD-dependent epimerase dehydratase K12454 - 5.1.3.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006538 591.0
HKD2_k127_9943177_16 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 593.0
HKD2_k127_9943177_17 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006282 551.0
HKD2_k127_9943177_18 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 523.0
HKD2_k127_9943177_19 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 515.0
HKD2_k127_9943177_2 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1052.0
HKD2_k127_9943177_20 alpha-L-arabinofuranosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 524.0
HKD2_k127_9943177_21 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006015 511.0
HKD2_k127_9943177_22 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 514.0
HKD2_k127_9943177_23 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006724 456.0
HKD2_k127_9943177_24 TGS domain K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000118 454.0
HKD2_k127_9943177_25 Two component regulator propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004104 489.0
HKD2_k127_9943177_26 Glycosyltransferase WbsX - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002551 461.0
HKD2_k127_9943177_27 Pyridoxal-phosphate dependent enzyme K01697,K01738 - 2.5.1.47,4.2.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 422.0
HKD2_k127_9943177_28 Male sterility protein K12454 - 5.1.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003543 424.0
HKD2_k127_9943177_29 Sulfotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 404.0
HKD2_k127_9943177_3 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 5.628e-302 945.0
HKD2_k127_9943177_30 TIGRFAM TIGR03032 family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008134 406.0
HKD2_k127_9943177_31 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008168 403.0
HKD2_k127_9943177_32 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009276 389.0
HKD2_k127_9943177_33 two component, sigma54 specific, transcriptional regulator, Fis family K02481 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 380.0
HKD2_k127_9943177_34 Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000024 376.0
HKD2_k127_9943177_35 Glycosyltransferase like family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 378.0
HKD2_k127_9943177_36 Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) K11784 - 1.21.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 371.0
HKD2_k127_9943177_37 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 353.0
HKD2_k127_9943177_38 Histidine kinase-like ATPases K01768,K02488,K17763 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65,4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005118 373.0
HKD2_k127_9943177_39 PFAM Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000347 331.0
HKD2_k127_9943177_4 DNA topoisomerase K02470,K02622 - 5.99.1.3 7.327e-284 884.0
HKD2_k127_9943177_40 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004721 326.0
HKD2_k127_9943177_41 Domain present in PSD-95, Dlg, and ZO-1/2. K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 322.0
HKD2_k127_9943177_42 zinc metalloprotease K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 308.0
HKD2_k127_9943177_43 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004535 287.0
HKD2_k127_9943177_44 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001659 292.0
HKD2_k127_9943177_45 Domain of unknown function (DUF1731) K07071 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000096 288.0
HKD2_k127_9943177_46 Transketolase, thiamine diphosphate binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007227 273.0
HKD2_k127_9943177_47 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001289 289.0
HKD2_k127_9943177_48 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002947 266.0
HKD2_k127_9943177_49 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000004236 273.0
HKD2_k127_9943177_5 ABC transporter K06020 - 3.6.3.25 1.325e-256 801.0
HKD2_k127_9943177_50 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000005262 269.0
HKD2_k127_9943177_51 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003029 269.0
HKD2_k127_9943177_52 COGs COG4299 conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007963 259.0
HKD2_k127_9943177_53 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000001112 265.0
HKD2_k127_9943177_54 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000001938 271.0
HKD2_k127_9943177_55 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000005613 235.0
HKD2_k127_9943177_56 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.000000000000000000000000000000000000000000000000000000000000000003728 240.0
HKD2_k127_9943177_57 diguanylate cyclase activity K13069 GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0052621 2.7.7.65 0.0000000000000000000000000000000000000000000000000000000000000000412 232.0
HKD2_k127_9943177_58 Ferritin-like domain K04047 - - 0.00000000000000000000000000000000000000000000000000000000000000007299 225.0
HKD2_k127_9943177_59 TPR repeat Sel1-like repeat Tetratricopeptide TPR_3 Tetratricopeptide TPR_2 - - - 0.00000000000000000000000000000000000000000000000000000000000000009646 254.0
HKD2_k127_9943177_6 TIGRFAM glutaminyl-tRNA synthetase K01886 - 6.1.1.18 2.676e-250 807.0
HKD2_k127_9943177_60 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K07106 - 4.2.1.126 0.0000000000000000000000000000000000000000000000000000000000000004055 239.0
HKD2_k127_9943177_61 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000009228 235.0
HKD2_k127_9943177_62 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000004732 228.0
HKD2_k127_9943177_63 Pfam Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000001014 223.0
HKD2_k127_9943177_64 PFAM peptidase K16922 - - 0.00000000000000000000000000000000000000000000000000000000008551 235.0
HKD2_k127_9943177_65 Ribulose-phosphate 3 epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000001511 222.0
HKD2_k127_9943177_66 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000000000000000000000004351 210.0
HKD2_k127_9943177_67 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000213 222.0
HKD2_k127_9943177_68 Epimerase dehydratase K19180 - 1.1.1.339 0.0000000000000000000000000000000000000000000000000004352 192.0
HKD2_k127_9943177_69 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000001507 195.0
HKD2_k127_9943177_7 4Fe-4S single cluster domain K06937 - - 2.509e-243 768.0
HKD2_k127_9943177_70 Belongs to the metallo-dependent hydrolases superfamily. NagA family K01443 - 3.5.1.25 0.0000000000000000000000000000000000000000000000002585 189.0
HKD2_k127_9943177_71 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.000000000000000000000000000000000000000000000002855 182.0
HKD2_k127_9943177_72 Beta-lactamase class A K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000000007122 193.0
HKD2_k127_9943177_73 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K01993,K16922 - - 0.00000000000000000000000000000000000000000000001034 196.0
HKD2_k127_9943177_74 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000001934 180.0
HKD2_k127_9943177_75 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000005692 186.0
HKD2_k127_9943177_76 Hsp20/alpha crystallin family K13993 - - 0.00000000000000000000000000000000000000000001438 168.0
HKD2_k127_9943177_77 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000001338 179.0
HKD2_k127_9943177_78 BadF BadG BcrA BcrD - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363 - 0.000000000000000000000000000000000000000004259 166.0
HKD2_k127_9943177_79 NlpC/P60 family - - - 0.0000000000000000000000000000000000000002525 169.0
HKD2_k127_9943177_8 PFAM FAD linked oxidase domain protein - - - 2.513e-217 682.0
HKD2_k127_9943177_80 Protein conserved in bacteria K20444 - - 0.0000000000000000000000000000000000000002538 173.0
HKD2_k127_9943177_81 PFAM TonB-dependent Receptor Plug Domain - - - 0.0000000000000000000000000000000000000003862 172.0
HKD2_k127_9943177_82 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000004463 168.0
HKD2_k127_9943177_83 Outer membrane protein beta-barrel family K16087,K16092 - - 0.000000000000000000000000000000000003547 158.0
HKD2_k127_9943177_84 EamA-like transporter family - - - 0.00000000000000000000000000000000002579 148.0
HKD2_k127_9943177_85 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000005294 134.0
HKD2_k127_9943177_86 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0005488,GO:0005507,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.0000000000000000000000000000006845 135.0
HKD2_k127_9943177_87 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000001657 138.0
HKD2_k127_9943177_88 Necessary for normal cell division and for the maintenance of normal septation K03978 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000009716 132.0
HKD2_k127_9943177_89 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000148 126.0
HKD2_k127_9943177_9 Prolyl oligopeptidase family - - - 8.09e-215 688.0
HKD2_k127_9943177_90 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000000000000025 124.0
HKD2_k127_9943177_91 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000001219 117.0
HKD2_k127_9943177_92 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.0000000000000000000000002451 124.0
HKD2_k127_9943177_93 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.0000000000000000000000003005 124.0
HKD2_k127_9943177_94 Serine aminopeptidase, S33 - - - 0.00000000000000000000001225 118.0
HKD2_k127_9943177_95 related to Ser Thr protein kinases K07102 GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 0.00000000000000000003016 102.0
HKD2_k127_9943177_96 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000008479 100.0
HKD2_k127_9943177_97 Rhodanese Homology Domain - - - 0.0000000000000000002049 92.0
HKD2_k127_9943177_98 - - - - 0.0000000000000000774 92.0
HKD2_k127_9943177_99 Glycosyltransferase like family 2 - - - 0.0000000000000001019 95.0
HKD2_k127_9952570_0 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 445.0
HKD2_k127_9952570_1 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002157 271.0