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Overview

ID MAG01795
Name HKD2_bin.4
Sample SMP0047
Taxonomy
Kingdom Archaea
Phylum Halobacteriota
Class Methanosarcinia
Order Methanotrichales
Family Methanotrichaceae
Genus JALHSR01
Species
Assembly information
Completeness (%) 75.2
Contamination (%) 2.94
GC content (%) 42.0
N50 (bp) 6,483
Genome size (bp) 1,925,229

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1739

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10043635_0 - - - - 1.638e-239 749.0
HKD2_k127_10043635_1 Flavodoxin - - - 0.00000000000000000000000000000000000000649 145.0
HKD2_k127_10043635_2 - - - - 0.0000000000000000000000000000000000000202 149.0
HKD2_k127_10051521_0 PFAM Cation K03498 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 360.0
HKD2_k127_10051521_1 Aldehyde dehydrogenase family K00294 - 1.2.1.88 0.00000000000000000000000000000000000000000000000000000000001515 214.0
HKD2_k127_10051521_2 secreted Zn-dependent protease - - - 0.000000000168 70.0
HKD2_k127_10064389_0 PFAM CBS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001629 282.0
HKD2_k127_10064389_1 Domain in cystathionine beta-synthase and other proteins. K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009625 256.0
HKD2_k127_10064389_2 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001183 230.0
HKD2_k127_10064389_3 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.000000000000000000000000000000000000000000000006708 176.0
HKD2_k127_10064389_4 signal transduction protein with CBS domains - - - 0.0000000000000000000000000000000000000000491 158.0
HKD2_k127_10064389_5 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.0000000000531 63.0
HKD2_k127_10071647_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 482.0
HKD2_k127_10071647_1 pfam nmd3 K07562 - - 0.0000000000000000000000000000000000000000000000000000000572 209.0
HKD2_k127_10071647_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K04794 - 3.1.1.29 0.000000000000000004474 85.0
HKD2_k127_10108807_0 Peptidase S9 prolyl oligopeptidase active site - - - 0.0000000000000000000000000000000000000001533 159.0
HKD2_k127_10108807_1 PFAM Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000006372 102.0
HKD2_k127_10108807_2 - - - - 0.0000000000000002858 83.0
HKD2_k127_10119119_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1069.0
HKD2_k127_10119119_1 in RNase L inhibitor, RLI K06174 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 591.0
HKD2_k127_10119119_2 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000183 209.0
HKD2_k127_10119119_3 RNase L inhibitor K06174 - - 0.000000000000000000000000000000000000000000000000000000002683 201.0
HKD2_k127_10119119_4 PIN domain of ribonuclease K07060 - - 0.0000000000000000000000000001005 120.0
HKD2_k127_10119119_5 RNase L inhibitor, RLI - - - 0.00000000000000000009725 94.0
HKD2_k127_10119119_6 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000003403 64.0
HKD2_k127_10122700_0 PFAM CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009256 614.0
HKD2_k127_10122700_1 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004526 358.0
HKD2_k127_10122700_2 Protein of unknown function (DUF2551) - - - 0.0000000000000000000000000000000000003962 141.0
HKD2_k127_10122700_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000042 135.0
HKD2_k127_10122700_4 PFAM Radical SAM domain protein K07129 - - 0.0000000000000000000000000000003823 126.0
HKD2_k127_10204143_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 6.449e-314 968.0
HKD2_k127_10204143_1 PFAM metal-dependent phosphohydrolase, HD sub domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 556.0
HKD2_k127_10204143_2 Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) K06868 - 2.5.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004228 477.0
HKD2_k127_10204143_3 PFAM Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000002917 146.0
HKD2_k127_10204143_4 Belongs to the glycosyl hydrolase 32 family K00692 - 2.4.1.10 0.0000000000000000000000000000000002022 142.0
HKD2_k127_10204143_5 Contacts the emerging nascent chain on the ribosome K03626 - - 0.0000000000000000000000000000005474 126.0
HKD2_k127_10204143_6 Cysteine-rich small domain K08260 - 3.5.1.90 0.000000000000000000006232 104.0
HKD2_k127_1091446_0 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - - 0.000000000000000000000000000000000000002059 149.0
HKD2_k127_1091446_1 - K00960 - 2.7.7.6 0.000000000000004083 76.0
HKD2_k127_1149392_0 integrase family K04763 - - 0.000000000000000000000000000000001439 136.0
HKD2_k127_1149392_1 integrase family K04763 - - 0.00005736 46.0
HKD2_k127_1171354_0 AAA family ATPase, CDC48 subfamily K13525 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004885 481.0
HKD2_k127_1171354_1 PFAM PRC-barrel domain - - - 0.000000000000000615 80.0
HKD2_k127_1171354_2 - - - - 0.0000000000000006512 84.0
HKD2_k127_1171354_3 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802,K03768 - 5.2.1.8 0.0008562 43.0
HKD2_k127_1209636_0 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007378 301.0
HKD2_k127_1209636_1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) - - - 0.0000000003782 68.0
HKD2_k127_133638_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0 1120.0
HKD2_k127_133638_1 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007205 356.0
HKD2_k127_133638_2 TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit K00172 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000001431 238.0
HKD2_k127_133638_3 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000004761 210.0
HKD2_k127_133638_4 4Fe-4S binding domain - - - 0.000000000000000000000000001536 113.0
HKD2_k127_133638_5 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.00000000000000006323 81.0
HKD2_k127_133638_6 4Fe-4S dicluster domain - - - 0.00000000000003972 74.0
HKD2_k127_133638_7 protein conserved in archaea K09723 - - 0.00001129 53.0
HKD2_k127_1414331_0 Uncharacterized conserved protein (DUF2173) - - - 0.0000000001188 67.0
HKD2_k127_1450951_0 methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000003197 214.0
HKD2_k127_1450951_1 Carbon-nitrogen hydrolase K01501,K01502 - 3.5.5.1,3.5.5.7 0.0000000000000000000000004739 109.0
HKD2_k127_1450951_2 Type II restriction enzyme K01155 - 3.1.21.4 0.00007694 53.0
HKD2_k127_1455167_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006169 341.0
HKD2_k127_1455167_1 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000001159 131.0
HKD2_k127_1473308_0 DNA polymerase beta domain protein region K09717 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002879 362.0
HKD2_k127_1473308_1 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 0.000000000000000000000000000000000000000000000000000000001034 206.0
HKD2_k127_1473308_2 TIGRFAM Sua5 YciO YrdC YwlC family protein K07566 - 2.7.7.87 0.00000000000000000000000000000000000000000000000001912 185.0
HKD2_k127_1473308_3 Helix-turn-helix XRE-family like proteins K03627 - - 0.000000000000000000000000000000000000004361 151.0
HKD2_k127_147790_0 Phytoene dehydrogenase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 414.0
HKD2_k127_147790_1 Dipeptidase K01439 - 3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004884 345.0
HKD2_k127_147790_10 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000001459 86.0
HKD2_k127_147790_11 - K14986 - 2.7.13.3 0.00000000000000143 85.0
HKD2_k127_147790_12 Phospholipid methyltransferase - - - 0.00000000000002643 80.0
HKD2_k127_147790_13 PFAM CBS domain containing protein - - - 0.0000000000006306 71.0
HKD2_k127_147790_14 - - - - 0.00004621 50.0
HKD2_k127_147790_15 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.00006612 46.0
HKD2_k127_147790_16 SPFH domain-Band 7 family - - - 0.0001055 55.0
HKD2_k127_147790_2 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 341.0
HKD2_k127_147790_3 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006731 258.0
HKD2_k127_147790_4 Sodium/hydrogen exchanger family - - - 0.00000000000000000000000000000000000000000000000000000000000003989 229.0
HKD2_k127_147790_5 PFAM CMP dCMP deaminase zinc-binding K01485 - 3.5.4.1 0.00000000000000000000000000000000000000000000000000002575 191.0
HKD2_k127_147790_6 - - - - 0.000000000000000000000000000000000000000000001451 173.0
HKD2_k127_147790_7 phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000001069 97.0
HKD2_k127_147790_8 membrane protein domain - - - 0.0000000000000000001863 92.0
HKD2_k127_147790_9 COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 - 0.000000000000000001343 92.0
HKD2_k127_14801_0 PFAM UDP-glucose GDP-mannose dehydrogenase K02472 - 1.1.1.336 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 452.0
HKD2_k127_14801_1 glycosyl transferase family 2 K07011 - - 0.00000000000000000000000000000005786 137.0
HKD2_k127_14801_2 asparagine synthase - - - 0.0000000000001158 74.0
HKD2_k127_151700_0 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00197 - 2.1.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003186 584.0
HKD2_k127_151700_1 Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing K00194 - 2.1.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 542.0
HKD2_k127_151700_10 Uncharacterized protein, homolog of nitrogen regulatory protein PII - - - 0.00000000000000000000006441 101.0
HKD2_k127_151700_11 PFAM nitrogen-fixing NifU - - - 0.000000000000000000005291 94.0
HKD2_k127_151700_12 - - - - 0.0000000000004392 73.0
HKD2_k127_151700_2 von Willebrand factor (vWF) type A domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 457.0
HKD2_k127_151700_3 Aerotolerance regulator N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000007065 231.0
HKD2_k127_151700_4 PFAM Phosphatidylglycerophosphatase A - - - 0.000000000000000000000000000000000000000000000000000000323 198.0
HKD2_k127_151700_5 MobA-like NTP transferase domain K19712 - 2.7.7.62 0.000000000000000000000000000000000000000000000000001235 190.0
HKD2_k127_151700_6 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate K02233 - 2.7.8.26 0.000000000000000000000000000000000000000000000007419 181.0
HKD2_k127_151700_7 Belongs to the SUI1 family K03113 - - 0.0000000000000000000000000000000000000000001644 161.0
HKD2_k127_151700_8 PFAM Like-Sm ribonucleoprotein, core - - - 0.00000000000000000000000006428 108.0
HKD2_k127_151700_9 B-block binding subunit of TFIIIC - - - 0.000000000000000000000003352 106.0
HKD2_k127_1519934_0 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 9.058e-199 629.0
HKD2_k127_1519934_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001795 430.0
HKD2_k127_1519934_2 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.0000000000000000000000000000000000000000000000001479 180.0
HKD2_k127_1519934_3 PFAM amino acid-binding ACT domain protein - - - 0.0000000000000000000000000000000000000000000003077 171.0
HKD2_k127_1550538_0 PFAM glycoside hydrolase 15-related - - - 7.262e-198 636.0
HKD2_k127_1550538_1 helicase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003301 506.0
HKD2_k127_1550538_2 PspA/IM30 family K03969 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005153 279.0
HKD2_k127_1550538_3 - - - - 0.00000000000000000000008835 100.0
HKD2_k127_1550538_4 4Fe-4S dicluster domain - - - 0.00000000000000000307 85.0
HKD2_k127_1550538_5 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000009898 83.0
HKD2_k127_1558757_0 Putative TM nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000000002298 213.0
HKD2_k127_1558757_1 PDGLE domain K02007,K02009 - - 0.0000000000000000000000000000000006907 132.0
HKD2_k127_1558757_2 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000008615 134.0
HKD2_k127_1558757_3 - - - - 0.000000000272 64.0
HKD2_k127_1613581_0 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000277 364.0
HKD2_k127_1613581_1 PFAM PP-loop domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004174 321.0
HKD2_k127_1648950_0 PFAM PP-loop - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000608 296.0
HKD2_k127_1648950_1 PP-loop domain protein K06864 - - 0.000000000000000000000000000000000000000000000000000000000000001714 224.0
HKD2_k127_1648950_2 Domain of unknown function (DUF1890) - - - 0.000000000000000000000000000000000000000000000000000000009232 201.0
HKD2_k127_1648950_3 Domain of unknown function (DUF1894) - - - 0.00000000000000000000000000000000000000002371 155.0
HKD2_k127_1648950_4 Domain of unknown function (DUF1894) - - - 0.00000000000000000000000005318 109.0
HKD2_k127_1671829_0 signal transduction protein with CBS domains K07744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 293.0
HKD2_k127_1671829_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007392 283.0
HKD2_k127_1671829_2 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000003884 213.0
HKD2_k127_1671829_3 phytol kinase activity K16368 GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0098827,GO:1901576 2.7.1.174 0.000000001864 67.0
HKD2_k127_1712320_0 Peptidase S9 prolyl oligopeptidase active site K01281 - 3.4.14.11 0.00000000000000000000000000000000000000000000000000000000000000000000003065 253.0
HKD2_k127_1712320_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000002132 137.0
HKD2_k127_1712320_2 Purple acid Phosphatase, N-terminal domain - - - 0.000000003262 68.0
HKD2_k127_1712320_3 PFAM glycosyl transferase family 35 K00688 - 2.4.1.1 0.0002065 44.0
HKD2_k127_1712320_4 virion core protein (lumpy skin disease virus) - - - 0.0006183 48.0
HKD2_k127_1734103_0 Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 391.0
HKD2_k127_1743246_0 TIGRFAM small GTP-binding protein K06943 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 297.0
HKD2_k127_1743246_1 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004903 287.0
HKD2_k127_1743246_2 Protein of unknown function (DUF1699) - - - 0.000000000000000000000000000000000000000004098 158.0
HKD2_k127_1743246_3 Gar1/Naf1 RNA binding region K07569 - - 0.00000000007411 66.0
HKD2_k127_178222_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 434.0
HKD2_k127_178222_1 PFAM UBA THIF-type NAD FAD binding protein K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009493 294.0
HKD2_k127_178222_2 PP-loop domain protein K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009444 267.0
HKD2_k127_178222_3 Domain of unknown function (DUF1894) - - - 0.00000000000000000000000000000000000000001054 156.0
HKD2_k127_178222_4 NifU-like N terminal domain K04488 - - 0.00000000000000000000000000000008933 126.0
HKD2_k127_178222_5 Transcriptional regulator K07108 - - 0.0000000000000000000000001104 109.0
HKD2_k127_1789699_0 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000000000000000008112 171.0
HKD2_k127_1789699_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000004493 104.0
HKD2_k127_1807034_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 2.144e-238 749.0
HKD2_k127_1807034_1 Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate K09011 - 2.3.1.182 3.319e-203 644.0
HKD2_k127_1807034_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006216 454.0
HKD2_k127_1807034_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009764 282.0
HKD2_k127_1807034_4 Acetolactate synthase, small subunit K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000005184 208.0
HKD2_k127_1807034_5 Transposase DDE domain - - - 0.00006777 50.0
HKD2_k127_1812645_0 DEAD DEAH box helicase domain protein K03724 - - 5.806e-281 884.0
HKD2_k127_1821968_0 TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000009964 261.0
HKD2_k127_1821968_1 - - - - 0.00000000000006696 77.0
HKD2_k127_1861662_0 Domain of unknown function (DUF4337) - - - 0.000000000000000000000000000000000000000000000000000000000000000006608 230.0
HKD2_k127_1861662_2 protein ubiquitination - - - 0.000008685 55.0
HKD2_k127_1919701_0 Domain of unknown function (DUF4331) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 432.0
HKD2_k127_1919701_1 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.00000000000000000000000000000000000000003443 158.0
HKD2_k127_1919701_2 Glyoxalase-like domain - - - 0.000000000000000000000000000000000005219 138.0
HKD2_k127_1919701_3 PFAM TM2 domain containing protein K03686 - - 0.0000000000000000006181 90.0
HKD2_k127_1919701_4 Cupin domain - - - 0.000000000000000007963 83.0
HKD2_k127_1919701_5 Cupin 2, conserved barrel domain protein - - - 0.0000000000003611 76.0
HKD2_k127_1919701_6 DNA polymerase activity K02319 - 2.7.7.7 0.0001259 47.0
HKD2_k127_1923200_0 oligoendopeptidase F K08602 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 509.0
HKD2_k127_1923200_1 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.000000003839 64.0
HKD2_k127_1923200_2 amino acid K02030 - - 0.0000005434 60.0
HKD2_k127_1995309_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.243e-223 706.0
HKD2_k127_1995309_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005315 547.0
HKD2_k127_1995309_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.000000000000000000000000000000000000000000000000000000000004837 217.0
HKD2_k127_1995309_3 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.000000000000000000000000000000000000000000001348 175.0
HKD2_k127_1995309_4 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000009538 111.0
HKD2_k127_1995309_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000006032 80.0
HKD2_k127_1995309_6 - - - - 0.0000000000004018 73.0
HKD2_k127_1996726_0 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000003022 239.0
HKD2_k127_1996726_1 COG1226 Kef-type K transport systems - - - 0.0000000000000000000000000000000000000000000000000000000000000002071 241.0
HKD2_k127_1996726_10 Uncharacterized protein containing a Zn-ribbon (DUF2116) - - - 0.00000004666 56.0
HKD2_k127_1996726_11 oxidoreductase activity K07114 - - 0.00000005506 64.0
HKD2_k127_1996726_12 Periplasmic copper-binding protein (NosD) K07218 - - 0.0001389 55.0
HKD2_k127_1996726_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000007345 202.0
HKD2_k127_1996726_3 phosphate binding protein K02040 - - 0.0000000000000000000000000000000000000000001271 169.0
HKD2_k127_1996726_4 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.00000000000000000000000000000000000000001157 162.0
HKD2_k127_1996726_5 - - - - 0.000000000000000000000000000007043 119.0
HKD2_k127_1996726_7 Protein of unknown function (DUF357) K09728 - - 0.000000000000000000007153 94.0
HKD2_k127_1996726_8 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.0000000000000002358 88.0
HKD2_k127_1996726_9 PFAM Periplasmic copper-binding protein (NosD) K07218 - - 0.000000008393 68.0
HKD2_k127_2029189_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 545.0
HKD2_k127_2029189_1 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001814 273.0
HKD2_k127_2029189_2 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.0000000000000000000000000000002158 123.0
HKD2_k127_2029189_3 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.000000000000000000000002477 106.0
HKD2_k127_2029189_4 PFAM YHS domain K01533,K17686 - 3.6.3.4,3.6.3.54 0.000000000000000001259 85.0
HKD2_k127_2029189_5 membrane - - - 0.000000000000000002031 94.0
HKD2_k127_2037968_0 Uncharacterized protein conserved in archaea (DUF2114) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003142 610.0
HKD2_k127_2037968_1 Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT( K01499 - 3.5.4.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 370.0
HKD2_k127_2037968_2 Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000005436 227.0
HKD2_k127_2037968_3 PBS lyase HEAT-like repeat - - - 0.0000000000000000114 94.0
HKD2_k127_2037968_4 but it may be involved in stabilization of the trimeric complex - - - 0.00000000000332 70.0
HKD2_k127_2093655_0 Putative small multi-drug export protein - - - 0.000000000000000000000000000000000000000000000000001502 188.0
HKD2_k127_2115898_0 PFAM CBS domain K03699 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007751 485.0
HKD2_k127_2115898_1 Elongator protein 3, MiaB family, Radical SAM K06935 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 325.0
HKD2_k127_2115898_2 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000000000000000000000000000000000000000000000000000002994 208.0
HKD2_k127_2115898_3 Glutaredoxin - - - 0.000000000000000000000000000001695 122.0
HKD2_k127_212679_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 499.0
HKD2_k127_212679_1 Uncharacterized protein family (UPF0051) K07033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007734 404.0
HKD2_k127_212679_10 - - - - 0.0000000008987 62.0
HKD2_k127_212679_2 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003363 344.0
HKD2_k127_212679_3 PFAM Exonuclease VII large subunit K03601 - 3.1.11.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000536 301.0
HKD2_k127_212679_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006766 285.0
HKD2_k127_212679_5 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001022 278.0
HKD2_k127_212679_6 TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ K02008 - - 0.0000000000000000000000000000000000000000000000000002131 194.0
HKD2_k127_212679_7 Kelch motif - - - 0.00000000000000000000001063 108.0
HKD2_k127_212679_8 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02009 - - 0.000000000000000805 80.0
HKD2_k127_212679_9 PFAM Exonuclease VII small subunit K03602 - 3.1.11.6 0.00000000002466 66.0
HKD2_k127_2183066_0 acid binding OB-fold tRNA helicase-type K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 445.0
HKD2_k127_2183066_1 ATP-grasp domain K06913 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001652 257.0
HKD2_k127_2183066_2 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.0000000000000000000000000000000000000000000000000000000000007498 214.0
HKD2_k127_2183066_3 Ribbon-helix-helix protein, copG family - - - 0.0006343 43.0
HKD2_k127_2208617_0 Ammonium Transporter K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 565.0
HKD2_k127_2208617_1 Ammonium Transporter Family K03320 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002828 397.0
HKD2_k127_2208617_10 4Fe-4S dicluster domain - - - 0.0000000002459 62.0
HKD2_k127_2208617_2 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000003727 260.0
HKD2_k127_2208617_3 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000001223 160.0
HKD2_k127_2208617_4 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000003835 156.0
HKD2_k127_2208617_5 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000000000000000000002471 152.0
HKD2_k127_2208617_6 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000236 120.0
HKD2_k127_2208617_7 4Fe-4S dicluster domain - - - 0.000000000000002283 78.0
HKD2_k127_2208617_8 FAD linked oxidase K18930 - - 0.000000000002951 72.0
HKD2_k127_2208617_9 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000001311 63.0
HKD2_k127_22353_0 Glycogen debranching enzyme - - - 0.0 1037.0
HKD2_k127_22353_1 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.0000000000000000000000000000000000000008278 150.0
HKD2_k127_22353_2 - - - - 0.000945 43.0
HKD2_k127_2242988_0 Thiamine biosynthesis protein ThiC K03147 - 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006613 499.0
HKD2_k127_2242988_1 pfam ammecr1 K09141 - - 0.000000000000000000000000000000000000000000000000002892 187.0
HKD2_k127_2242988_2 beta-lactamase domain protein - - - 0.000000000000000000000000000000000000166 147.0
HKD2_k127_2246619_0 low-complexity proteins - - - 0.0000000000009462 81.0
HKD2_k127_2279179_0 Sulfate permease K03321 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 404.0
HKD2_k127_2300988_0 - - - - 0.00000000000000000000000000000000000000371 153.0
HKD2_k127_2300988_1 PFAM TM2 domain containing protein K03686 - - 0.000000000000000001596 89.0
HKD2_k127_2329180_0 Transposase domain (DUF772) K07481 - - 0.000000000000000000000000000000000000000000000000000000000000000124 226.0
HKD2_k127_2329180_1 Transposase domain (DUF772) K07481 - - 0.00000000000000000000000000000000001194 139.0
HKD2_k127_2329180_2 - - - - 0.0000000000000000000000000000026 126.0
HKD2_k127_2400134_0 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000005363 203.0
HKD2_k127_2400134_1 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway K00852 - 2.7.1.15 0.000000000000000000000000000004619 132.0
HKD2_k127_2400134_2 Flavodoxin domain K00230 - 1.3.5.3 0.0000000000000000000000000002174 121.0
HKD2_k127_2400134_3 PspC domain K03973 - - 0.000000000000000000255 90.0
HKD2_k127_2400969_0 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 338.0
HKD2_k127_2400969_1 ABC-type tungstate transport system, periplasmic component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001949 262.0
HKD2_k127_2400969_2 ATPases associated with a variety of cellular activities K02017 - 3.6.3.29 0.000000000000000000000000000000000000000000000000000000000000000522 229.0
HKD2_k127_2400969_3 Ion channel K10716 - - 0.000000000000000000000000000000000000000000000000000000000001902 218.0
HKD2_k127_2406640_0 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 343.0
HKD2_k127_2406640_1 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000000000000000002954 188.0
HKD2_k127_2406640_2 Non-histone chromosomal protein MC1 - - - 0.000000000000000000000000000499 115.0
HKD2_k127_2406640_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.00000000000001114 86.0
HKD2_k127_241327_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007767 272.0
HKD2_k127_241327_1 Threonyl-tRNA synthetase K01868 - 6.1.1.3 0.00000000000000000000000000000000000000003729 155.0
HKD2_k127_241327_2 Winged helix-turn-helix DNA-binding - - - 0.000000000000000000000007341 103.0
HKD2_k127_241327_3 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000001249 101.0
HKD2_k127_241327_5 COG1977 Molybdopterin converting factor, small subunit K03636 GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564 - 0.00000000001037 68.0
HKD2_k127_2459283_0 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 1.393e-194 618.0
HKD2_k127_2459283_1 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005862 252.0
HKD2_k127_2459283_2 Protein of unknown function DUF89 K09116 - - 0.0000000000000000000000000000000000003447 151.0
HKD2_k127_2459283_3 PAC2 family K07159 - - 0.0000000000000000000000002084 114.0
HKD2_k127_2459283_4 DNA polymerase beta domain protein region K09717 - - 0.00000000000000000000005135 99.0
HKD2_k127_2473167_0 PFAM glycosyl transferase family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 3.528e-275 864.0
HKD2_k127_2473167_1 PFAM glycosyl transferase group 1 K13057 - 2.4.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 534.0
HKD2_k127_2473167_2 Glucose / Sorbosone dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 507.0
HKD2_k127_2473167_3 Cation transport regulator K06197 - - 0.00000000000000000000000000008275 116.0
HKD2_k127_2502904_0 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into K04799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 378.0
HKD2_k127_2502904_1 PFAM Diphthamide synthesis DPH2 protein K07561 - 2.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007969 316.0
HKD2_k127_2502904_2 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 290.0
HKD2_k127_2502904_3 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family K02503,K19710,K21220 - 2.5.1.3,2.7.7.53 0.0000000000000000000002097 102.0
HKD2_k127_2502904_4 Iron-sulphur cluster biosynthesis K15724 - - 0.00000000008379 67.0
HKD2_k127_2527025_0 Transposase domain (DUF772) K07481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 298.0
HKD2_k127_2527025_1 PFAM NAD dependent epimerase dehydratase family K01710,K01784 - 4.2.1.46,5.1.3.2 0.00000006864 53.0
HKD2_k127_2559854_0 TIGRFAM UbiD family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004922 467.0
HKD2_k127_2559854_1 Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis K11646 - 1.4.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 440.0
HKD2_k127_2559854_2 Protein of unknown function (DUF1614) - - - 0.0000000000000000000000000000000000000000000000000000000000000000001117 237.0
HKD2_k127_2559854_3 Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate K03785 - 4.2.1.10 0.0000000000000000000000000000000000000000005021 165.0
HKD2_k127_2559854_4 Transposase domain (DUF772) K07481 - - 0.0000000000000000000001834 99.0
HKD2_k127_2576978_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261,K00262 - 1.4.1.2,1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 429.0
HKD2_k127_2576978_1 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006468 301.0
HKD2_k127_259795_0 Immune inhibitor A peptidase M6 K09607 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005868 448.0
HKD2_k127_259795_1 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 314.0
HKD2_k127_259795_2 alpha beta - - - 0.0000000000000000000000000000000000000000000000000000000000000005428 233.0
HKD2_k127_259795_3 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.00000000000000000000000000000000000000000002417 168.0
HKD2_k127_259795_4 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.0000000000000000001263 90.0
HKD2_k127_26341_0 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 2.968e-277 869.0
HKD2_k127_26341_1 Starch synthase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 434.0
HKD2_k127_26341_2 Dimerisation domain - - - 0.000000000000000000000000000000000000000000003769 167.0
HKD2_k127_26341_3 Rhodanese Homology Domain - - - 0.0000000000000000000009378 100.0
HKD2_k127_26341_4 Dodecin K09165 - - 0.000000000000000815 78.0
HKD2_k127_26341_5 Pyridoxal-dependent decarboxylase conserved domain - - - 0.0000002959 56.0
HKD2_k127_2763279_0 aconitate hydratase K01681 - 4.2.1.3 3.064e-259 813.0
HKD2_k127_2763279_1 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 - 2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 533.0
HKD2_k127_2763279_2 Domain of unknown function (DUF814) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007425 501.0
HKD2_k127_2763279_3 PFAM PUA domain containing protein K07557 - 2.6.1.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004544 438.0
HKD2_k127_2763279_4 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009097 357.0
HKD2_k127_2763279_5 Mut7-C RNAse domain K09122 - - 0.0000000000000000000000000000001698 128.0
HKD2_k127_2763279_6 Transglutaminase-like superfamily - - - 0.0007322 46.0
HKD2_k127_2770359_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004774 400.0
HKD2_k127_2770359_1 Transposase domain (DUF772) K07481 - - 0.00000000002462 67.0
HKD2_k127_2770359_2 Transposase domain (DUF772) K07481 - - 0.0000004634 57.0
HKD2_k127_2840317_0 Arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009938 286.0
HKD2_k127_2840317_1 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000008858 261.0
HKD2_k127_2840317_2 Protein of unknown function DUF116 K09729 - - 0.0000000000000000000000000000000000000000000000000000000343 205.0
HKD2_k127_2840317_4 CHAT domain - - - 0.0003237 50.0
HKD2_k127_2891229_0 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 295.0
HKD2_k127_2891229_1 integrase family K04763 - - 0.00000007335 54.0
HKD2_k127_290831_0 Involved in cell shape control K22222 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001011 412.0
HKD2_k127_290831_1 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000005877 261.0
HKD2_k127_290831_2 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.0000000000000000000000000000000000004706 145.0
HKD2_k127_290831_3 - - - - 0.000003223 59.0
HKD2_k127_2918723_0 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000000000000000000000000000000522 214.0
HKD2_k127_2918723_1 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K02030 - - 0.0000004257 52.0
HKD2_k127_2921725_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002905 378.0
HKD2_k127_2921725_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005524 289.0
HKD2_k127_2921725_2 - - - - 0.0000000000000001138 85.0
HKD2_k127_2921725_3 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000005861 76.0
HKD2_k127_2921725_4 Belongs to the AAA ATPase family K07392 - - 0.000000001476 61.0
HKD2_k127_2990248_0 Thiamine pyrophosphate enzyme, C-terminal K00187 - 1.2.7.7 1.505e-200 634.0
HKD2_k127_2990248_1 ferredoxin oxidoreductase K00186 - 1.2.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 501.0
HKD2_k127_2990248_2 Domain of unknown function (DUF2088) - - - 0.00001884 48.0
HKD2_k127_2991569_0 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 5.462e-265 830.0
HKD2_k127_2991569_1 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000007909 225.0
HKD2_k127_2991569_2 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000001298 182.0
HKD2_k127_2991569_3 Pyruvate:ferredoxin oxidoreductase core domain II K00186 - 1.2.7.7 0.00000000000000000000000000000000000000000001777 163.0
HKD2_k127_2991569_4 Chagasin family peptidase inhibitor I42 K14475 - - 0.0003153 51.0
HKD2_k127_303937_0 PFAM Iron-containing alcohol dehydrogenase K00001,K13954 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002283 362.0
HKD2_k127_303937_1 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005431 363.0
HKD2_k127_303937_2 Nadph-dependent fmn reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001257 285.0
HKD2_k127_303937_3 Iron-containing alcohol dehydrogenase K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000005256 241.0
HKD2_k127_303937_4 Flavodoxin - - - 0.00000000000000000000000000000000000000000000000000000000000000006354 223.0
HKD2_k127_303937_5 PFAM helix-turn-helix HxlR type - - - 0.000000000000000000000000000000000000000000000000000000000000001199 220.0
HKD2_k127_303937_6 Cyclophilin-like K09143 - - 0.000000000000000000000000000000000012 139.0
HKD2_k127_303937_7 PFAM nuclease (SNase domain protein) - - - 0.0000000000000000001949 93.0
HKD2_k127_303937_8 NADPH-dependent FMN reductase - - - 0.000000000007597 67.0
HKD2_k127_3044821_0 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002622 349.0
HKD2_k127_3044821_1 oxidoreductase activity K07114 - - 0.0000006352 61.0
HKD2_k127_3070824_0 thiamine pyrophosphate enzyme domain protein TPP-binding K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 362.0
HKD2_k127_3070824_1 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000756 353.0
HKD2_k127_3070824_2 phenylalanyl-tRNA synthetase, beta subunit K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001477 286.0
HKD2_k127_3070824_3 Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP K11176 - 3.5.4.10 0.00000000000000000000000000000000000000000000000002563 185.0
HKD2_k127_3070824_4 PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00169 - 1.2.7.1 0.000001036 51.0
HKD2_k127_3075591_0 radical SAM domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 350.0
HKD2_k127_3075591_1 Diphthamide synthase K06927 - 6.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000007704 249.0
HKD2_k127_3075591_2 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000003948 245.0
HKD2_k127_3075591_3 PFAM Glutamine amidotransferase class-I - - - 0.000000000000000000000000000000000000003273 152.0
HKD2_k127_3075591_4 Belongs to the alpha-IPM synthase homocitrate synthase family K10977 - 2.3.3.14 0.0000000000000000000000000000000000007617 141.0
HKD2_k127_3075591_5 Uncharacterized protein conserved in archaea (DUF2240) - - - 0.000000000000009259 81.0
HKD2_k127_3075591_6 Polysaccharide deacetylase - - - 0.0002344 55.0
HKD2_k127_3166914_0 Histidine Phosphotransfer domain - - - 0.00000000000000000000000000000000000000000002655 167.0
HKD2_k127_3205006_0 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 364.0
HKD2_k127_3205006_1 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 292.0
HKD2_k127_3205006_2 Ferredoxin K05337 - - 0.000000000000000009972 87.0
HKD2_k127_3205006_3 - - - - 0.0000000000000002013 85.0
HKD2_k127_3205006_4 haloacid dehalogenase-like hydrolase K01533 - 3.6.3.4 0.00000000000002433 76.0
HKD2_k127_3205006_5 YHS domain - - - 0.000000000001993 68.0
HKD2_k127_3205006_6 Short C-terminal domain K08982 - - 0.0000368 49.0
HKD2_k127_320657_0 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.0000000000000000000000000000000000000000000000000000000000004633 219.0
HKD2_k127_320657_1 Domain of unknown function (DUF4870) K09940 - - 0.0000000000000000000000000003686 119.0
HKD2_k127_320657_2 Phosphoserine phosphatase - - - 0.0000000000009138 79.0
HKD2_k127_320657_3 - - - - 0.00000003423 62.0
HKD2_k127_32683_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K09759 - 6.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002947 570.0
HKD2_k127_32683_1 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008691 559.0
HKD2_k127_32683_10 Oxidoreductase family, NAD-binding Rossmann fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 336.0
HKD2_k127_32683_11 Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) K15449 - 4.1.3.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 336.0
HKD2_k127_32683_12 Hexapeptide repeat of succinyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004782 267.0
HKD2_k127_32683_13 PFAM Nitroreductase - - - 0.00000000000000000000000000000000000000000006548 166.0
HKD2_k127_32683_14 PFAM ribosomal protein S8E K02995 - - 0.0000000000000000000000000000000000000000002183 162.0
HKD2_k127_32683_15 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 0.00000000000000000000000009526 110.0
HKD2_k127_32683_16 cheY-homologous receiver domain - - - 0.0000000000000000000007621 99.0
HKD2_k127_32683_17 Pentapeptide repeats (9 copies) - - - 0.0000000001233 74.0
HKD2_k127_32683_18 Glycosyl transferase 4-like - - - 0.000000009374 67.0
HKD2_k127_32683_19 Calcineurin-like phosphoesterase - - - 0.00007202 54.0
HKD2_k127_32683_2 histone acetyltransferase, ELP3 family K07739 - 2.3.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000685 520.0
HKD2_k127_32683_3 UDP-N-acetylglucosamine 2-epimerase K01791 - 5.1.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 472.0
HKD2_k127_32683_4 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004084 452.0
HKD2_k127_32683_5 phosphoserine phosphatase activity K01079,K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003832 478.0
HKD2_k127_32683_6 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001708 451.0
HKD2_k127_32683_7 Beta-eliminating lyase K13010 - 2.6.1.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 445.0
HKD2_k127_32683_8 PFAM transferase hexapeptide repeat containing protein K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001922 410.0
HKD2_k127_32683_9 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 382.0
HKD2_k127_3273768_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003167 479.0
HKD2_k127_3273768_1 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.000000000000000000000000000000000000000000000000001607 187.0
HKD2_k127_3273768_2 TIGRFAM peptidase S26B, signal peptidase K13280 - 3.4.21.89 0.000000000000000000000000000000000000000000005095 172.0
HKD2_k127_3390671_0 Dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004613 286.0
HKD2_k127_3390671_1 PFAM Cache, type 2 domain protein K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000004683 243.0
HKD2_k127_3390671_2 alkylhydroperoxidase like protein, AhpD family - - - 0.000000000000000000000000004667 113.0
HKD2_k127_3390671_3 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.0000000000000000000000001209 113.0
HKD2_k127_3390671_4 ARD/ARD' family K01607 - 4.1.1.44 0.00000000000000003157 85.0
HKD2_k127_3390671_5 Nitroreductase - - - 0.000000001678 63.0
HKD2_k127_3390671_6 Belongs to the 'phage' integrase family K03733,K04763 - - 0.0000001406 57.0
HKD2_k127_3397488_0 PFAM AIR synthase related protein K07123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 380.0
HKD2_k127_3397488_1 methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000005786 199.0
HKD2_k127_3397488_2 AMP-binding enzyme C-terminal domain K01912 - 6.2.1.30 0.0000000000526 64.0
HKD2_k127_3415500_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004185 459.0
HKD2_k127_3415500_1 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.0000000000000000000000000000000000000000000000000000002922 196.0
HKD2_k127_3415500_2 - K01489 - 3.5.4.5 0.0000000000000003239 83.0
HKD2_k127_3415500_3 Phospholipid methyltransferase - - - 0.000001232 54.0
HKD2_k127_3498341_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000001071 86.0
HKD2_k127_3498341_3 - - - - 0.00000000000002895 78.0
HKD2_k127_3511853_0 Oxidoreductase NAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000338 240.0
HKD2_k127_3511853_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000002682 203.0
HKD2_k127_3511853_2 PFAM Transposase IS116 IS110 IS902 family - - - 0.000000000000000000000000000000000009045 141.0
HKD2_k127_3511853_3 transposase IS116 IS110 IS902 family protein - - - 0.00002471 48.0
HKD2_k127_3627427_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 3.199e-275 857.0
HKD2_k127_3627427_1 PFAM peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 462.0
HKD2_k127_3640450_0 PFAM chaperonin Cpn60 TCP-1 K22447 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002779 531.0
HKD2_k127_3640450_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 370.0
HKD2_k127_3640450_2 Phosphate uptake regulator - - - 0.00000000000000000000000000000000000000000000000000002797 200.0
HKD2_k127_3640450_3 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.000000000000000000000000000000000000000000008428 171.0
HKD2_k127_3640450_4 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.0000000000000000000000000000000000000000003506 167.0
HKD2_k127_3640450_5 PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding K00567 - 2.1.1.63 0.0000000000000000000107 97.0
HKD2_k127_3657333_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 499.0
HKD2_k127_3657333_1 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 501.0
HKD2_k127_3657333_10 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000001563 163.0
HKD2_k127_3657333_11 TfuA-like protein - - - 0.0000000000000000000000000000000000000000004996 165.0
HKD2_k127_3657333_12 Thioesterase superfamily K02614 - - 0.000000000000000000000000000000000001044 142.0
HKD2_k127_3657333_13 - - - - 0.0000000000001388 76.0
HKD2_k127_3657333_14 COG1977 Molybdopterin converting factor, small subunit K03636 - - 0.0000000001254 65.0
HKD2_k127_3657333_2 aromatic amino acid beta-eliminating lyase threonine aldolase K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 462.0
HKD2_k127_3657333_3 AIR synthase related protein domain protein K04655 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003106 444.0
HKD2_k127_3657333_4 aminotransferase class I and II K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004902 439.0
HKD2_k127_3657333_5 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003246 398.0
HKD2_k127_3657333_6 Thiamine-phosphate synthase K21220 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000002265 261.0
HKD2_k127_3657333_7 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000194 248.0
HKD2_k127_3657333_8 PP-loop domain protein K06864 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001186 247.0
HKD2_k127_3657333_9 Functions by promoting the formation of the first peptide bond K03263 - - 0.000000000000000000000000000000000000000000001019 168.0
HKD2_k127_3702680_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003352 439.0
HKD2_k127_3702680_1 C-terminal region of MMR_HSR1 domain K06944 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005592 421.0
HKD2_k127_3702680_2 Subtilase family K17734 - - 0.000000000000000000000000000000000000000000000000000000006404 227.0
HKD2_k127_3702680_3 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.000000000000000000000000000000000000000000000000004151 190.0
HKD2_k127_3702680_4 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000001641 159.0
HKD2_k127_3702680_5 CDP-alcohol phosphatidyltransferase K17103 - 2.7.8.8 0.0000000000000000000000000000003655 131.0
HKD2_k127_3702680_6 Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) K09739 - 4.1.2.25 0.000000000000000000000000000008758 121.0
HKD2_k127_3760315_0 AAA domain, putative AbiEii toxin, Type IV TA system K02006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006939 408.0
HKD2_k127_3760315_1 Cobalt transport protein K02008 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 370.0
HKD2_k127_3760315_2 NYN domain - - - 0.00000000000000000000000000000000000000000000000000065 190.0
HKD2_k127_3760315_3 PFAM FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000000000000000000000000001266 163.0
HKD2_k127_3760315_4 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008677,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.1.1.169 0.00000009365 57.0
HKD2_k127_3776505_0 CHAT domain - - - 0.0000000000000000000000000000000000000000000001744 191.0
HKD2_k127_3776505_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000007302 127.0
HKD2_k127_3776505_2 Tetratricopeptide repeat - - - 0.000000000000000000004193 108.0
HKD2_k127_3787697_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004244 453.0
HKD2_k127_3787697_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821 - 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007494 440.0
HKD2_k127_3787697_2 Belongs to the ALAD family K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000338 359.0
HKD2_k127_3787697_3 PFAM Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 319.0
HKD2_k127_3787697_4 SMART regulatory protein AsnC Lrp family K22225 - - 0.00000000000000000000000000000000000000000000001904 175.0
HKD2_k127_3787697_5 TIGRFAM siroheme synthase K02304 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.76,4.99.1.4 0.00000000000000000000000000000000000000000002618 170.0
HKD2_k127_3787697_6 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.000000000000000000000000000000000000006589 151.0
HKD2_k127_3787697_7 PAS domain - - - 0.000000000000000163 93.0
HKD2_k127_3787697_8 beta-lactamase domain protein - - - 0.00009202 45.0
HKD2_k127_3940500_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008797 575.0
HKD2_k127_3940500_1 PFAM Radical SAM domain protein K07129 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 299.0
HKD2_k127_3985590_0 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 417.0
HKD2_k127_3985590_1 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11780 - 2.5.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000221 348.0
HKD2_k127_3985590_10 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA K00584 - 2.1.1.86 0.00000000602 57.0
HKD2_k127_3985590_2 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008435 328.0
HKD2_k127_3985590_3 Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT K00319 - 1.5.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 308.0
HKD2_k127_3985590_4 Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP K11212 - 2.7.8.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 300.0
HKD2_k127_3985590_5 Belongs to the UPF0285 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002251 278.0
HKD2_k127_3985590_6 ZPR1-related zinc finger protein K06874 - - 0.000000000000000000000000000000000000000000000000004132 187.0
HKD2_k127_3985590_7 Belongs to the UPF0179 family K09730 - - 0.0000000000000000000000000000000000000000002164 162.0
HKD2_k127_3985590_8 Pfam:DUF552 K09152 - - 0.000000000000000000005536 96.0
HKD2_k127_3985590_9 Putative zinc- or iron-chelating domain K06940 - - 0.000000004256 66.0
HKD2_k127_4026448_0 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007111 498.0
HKD2_k127_4026448_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000001218 252.0
HKD2_k127_4026448_2 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.000000000000000000000000000000000000000000000000005007 185.0
HKD2_k127_4026448_3 6-phosphogluconolactonase activity - - - 0.0000000000000005888 90.0
HKD2_k127_4088738_0 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A K02188 - 2.1.1.195 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 303.0
HKD2_k127_4088738_1 PFAM Precorrin-8X methylmutase CbiC CobH K06042 - 5.4.99.60,5.4.99.61 0.000000000000000000000000000000000000000000000000000000000000002853 224.0
HKD2_k127_4088738_2 PFAM cobalamin (vitamin B12) biosynthesis CbiG protein K02189 - 3.7.1.12 0.00000000000000000000000000000000000000000000000000157 194.0
HKD2_k127_4088738_3 Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit K03399 - 2.1.1.289 0.00000000000000000000000000000000000000001716 160.0
HKD2_k127_4088738_4 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05934,K21479 - 2.1.1.131,2.1.1.272 0.0000000000000000000000000000000000000002472 166.0
HKD2_k127_4088738_5 Belongs to the UPF0147 family K09721 - - 0.0000000000000000000000000006318 115.0
HKD2_k127_4088738_6 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.00000000000000000000000003317 109.0
HKD2_k127_4088738_7 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) K07143 - - 0.0000000003705 66.0
HKD2_k127_4090639_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002136 359.0
HKD2_k127_4090639_1 PFAM Adenosine specific kinase K09129 - - 0.000000000000000000000000000000000000000000000000000000000000000005078 228.0
HKD2_k127_4090639_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000001897 76.0
HKD2_k127_4098844_0 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 415.0
HKD2_k127_4098844_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009258 341.0
HKD2_k127_4098844_2 Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) K11781 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005645 345.0
HKD2_k127_4098844_3 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000001035 245.0
HKD2_k127_4098844_4 PFAM Deoxyribonuclease rho motif-related TRAM - - - 0.0000000000000000000003616 97.0
HKD2_k127_41006_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007939 588.0
HKD2_k127_41006_1 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K22012 - 6.3.5.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005071 490.0
HKD2_k127_41006_2 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K02588,K21610 - 1.18.6.1,6.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 357.0
HKD2_k127_41006_3 Mn2 dependent serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 352.0
HKD2_k127_41006_4 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000007903 189.0
HKD2_k127_41006_5 PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding K07006 - - 0.0000000000000000000000000000001617 127.0
HKD2_k127_41006_6 S-layer protein - - - 0.00000000000000007526 87.0
HKD2_k127_414203_0 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000036 480.0
HKD2_k127_414203_1 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 446.0
HKD2_k127_414203_10 Cupin domain - - - 0.000000000211 61.0
HKD2_k127_414203_11 Cupin domain - - - 0.00001077 50.0
HKD2_k127_414203_12 - - - - 0.00003241 48.0
HKD2_k127_414203_2 Belongs to the dihydrofolate reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003935 321.0
HKD2_k127_414203_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000007549 254.0
HKD2_k127_414203_4 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11747 - - 0.000000000000000000000000000000000000000000000000000000006747 204.0
HKD2_k127_414203_5 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.00000000000000000000000000000000000000000001747 165.0
HKD2_k127_414203_6 homolog of gamma-carboxymuconolactone decarboxylase subunit - - - 0.00000000000000000000000000000000000000001623 157.0
HKD2_k127_414203_7 PFAM Chromate transporter K07240 - - 0.00000000000000000000000000000003388 128.0
HKD2_k127_414203_8 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000001494 122.0
HKD2_k127_414203_9 Hemerythrin HHE cation binding K07322 - - 0.0000000000005245 71.0
HKD2_k127_415057_0 Has ATPase and non-specific DNA-binding activities K07456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 419.0
HKD2_k127_415057_1 Transcriptional regulator, TrmB - - - 0.000000000000000000000000000000000002575 141.0
HKD2_k127_415057_2 - - - - 0.000000000000000000000000000000000007609 147.0
HKD2_k127_415057_3 Sulfur transfer protein involved in thiamine biosynthesis K03154,K21947 GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564 2.8.1.15 0.000000005514 59.0
HKD2_k127_4151952_0 S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe) K07055 - 2.5.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004057 316.0
HKD2_k127_4151952_1 PFAM metallophosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000001327 238.0
HKD2_k127_4151952_2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000005605 186.0
HKD2_k127_4187996_0 ABC-type tungstate transport system, periplasmic component K05773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001956 254.0
HKD2_k127_4187996_1 ATPases associated with a variety of cellular activities K02017 - 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000000000001445 244.0
HKD2_k127_4187996_2 - - - - 0.00000000000000000000000000000000000000000000005189 173.0
HKD2_k127_4187996_3 Magnesium transport protein CorA K03284,K16074 GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - 0.000000000000000000000000002492 123.0
HKD2_k127_4187996_4 Transcriptional regulator K09714 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000001514 111.0
HKD2_k127_4187996_5 chromate transport K07240 - - 0.0000000000000003247 80.0
HKD2_k127_4187996_6 extracellular solute-binding protein, family 1 K05772 - - 0.00000006157 55.0
HKD2_k127_4187996_7 PFAM Chromate transporter K07240 - - 0.0001065 48.0
HKD2_k127_4197325_0 Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin K17488 - 3.5.4.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005741 398.0
HKD2_k127_4197325_1 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.00000000000000000000000000000000000000000000000000000000000000000005577 237.0
HKD2_k127_4197325_2 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.0000000000000000000000000000000008978 136.0
HKD2_k127_4197325_3 Belongs to the eukaryotic ribosomal protein eS1 family K02984 - - 0.00000000000000000000000003698 109.0
HKD2_k127_4201727_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 525.0
HKD2_k127_4201727_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 510.0
HKD2_k127_4201727_2 PFAM AIR synthase related protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 434.0
HKD2_k127_4201727_3 PFAM Cobyrinic acid a,c-diamide synthase K07321 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 328.0
HKD2_k127_4201727_4 PFAM nuclease (SNase domain protein) - - - 0.000002324 57.0
HKD2_k127_4203238_0 PFAM isocitrate isopropylmalate dehydrogenase K10978 - 1.1.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 395.0
HKD2_k127_4203238_1 PFAM ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 294.0
HKD2_k127_4203238_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004402 260.0
HKD2_k127_4203238_3 Uncharacterized protein family (UPF0051) K07033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004273 253.0
HKD2_k127_4203238_4 Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B K16793 - 4.2.1.114 0.00000000000000000000000000000000000000000000000000000000000005199 218.0
HKD2_k127_4203238_5 transposase activity K07481 - - 0.000000002566 59.0
HKD2_k127_4226894_0 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000000000000000000000000000000000000000006323 179.0
HKD2_k127_4226894_1 transposition, DNA-mediated - - - 0.0000000000000000000000000000000000002261 145.0
HKD2_k127_4226894_2 CHASE - - - 0.00000000000000000000000001879 113.0
HKD2_k127_4226894_3 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000001227 110.0
HKD2_k127_4226894_4 PFAM CBS domain containing protein - - - 0.00000000000000000002017 96.0
HKD2_k127_4226894_5 alpha-amylase - - - 0.0002517 55.0
HKD2_k127_4229076_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000008983 169.0
HKD2_k127_4229076_1 Amidohydrolase family - - - 0.00000000000000000000000000000000000000001436 164.0
HKD2_k127_4229076_2 PFAM Secreted repeat of - - - 0.000000000000000001163 89.0
HKD2_k127_4229076_3 4Fe-4S binding domain - - - 0.0001416 44.0
HKD2_k127_4275123_0 KH, type 1, domain K07041 - - 2.299e-311 963.0
HKD2_k127_4275123_1 DEAD DEAH box helicase domain protein K03725 - - 4.169e-231 740.0
HKD2_k127_4275123_10 Membrane protein of unknown function DUF63 - - - 0.0000000000000000000000000000000000000000000000000000000006228 211.0
HKD2_k127_4275123_11 ArsR transcriptional regulator - - - 0.000000000000000000000000000000000000000000000002047 178.0
HKD2_k127_4275123_12 Starch synthase catalytic domain - - - 0.00000000000000000002921 94.0
HKD2_k127_4275123_13 COG0184 Ribosomal protein S15P S13E K02956 - - 0.00001771 48.0
HKD2_k127_4275123_2 PFAM PilT protein domain protein K06865 - - 1.652e-212 676.0
HKD2_k127_4275123_3 Glycogen synthase - - - 6.649e-201 641.0
HKD2_k127_4275123_4 Starch synthase catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 455.0
HKD2_k127_4275123_5 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009963 439.0
HKD2_k127_4275123_6 SMART regulatory protein, Crp K07730 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 329.0
HKD2_k127_4275123_7 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006313 287.0
HKD2_k127_4275123_8 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 - 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000001333 261.0
HKD2_k127_4275123_9 Circadian clock protein KaiC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001976 250.0
HKD2_k127_4287950_0 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001279 539.0
HKD2_k127_4287950_1 Protein-export membrane protein SecD K03072 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001789 350.0
HKD2_k127_4287950_2 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002557 287.0
HKD2_k127_4287950_3 Involved in protein export K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001917 274.0
HKD2_k127_4299630_0 Transposase domain (DUF772) K07481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003221 347.0
HKD2_k127_4311348_0 PFAM ornithine cyclodeaminase mu-crystallin K01750 - 4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000001042 226.0
HKD2_k127_4343692_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003504 586.0
HKD2_k127_4343692_1 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004907 533.0
HKD2_k127_4343692_2 Pyridine nucleotide-disulphide oxidoreductase K00382,K00383 - 1.8.1.4,1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000001528 261.0
HKD2_k127_4343692_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000004675 124.0
HKD2_k127_4343692_4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules K04763 - - 0.0000000000000000000002766 104.0
HKD2_k127_4343692_5 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00383 - 1.8.1.7 0.00000000318 58.0
HKD2_k127_4343692_6 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382,K00383 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4,1.8.1.7 0.00003922 47.0
HKD2_k127_435828_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 332.0
HKD2_k127_435828_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000103 60.0
HKD2_k127_4359054_0 PFAM low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000002511 184.0
HKD2_k127_4376847_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit K02118 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 297.0
HKD2_k127_4376847_1 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.0000000000000000000000000000000000000000000000000000000000000000001407 237.0
HKD2_k127_4376847_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000003756 221.0
HKD2_k127_4376847_3 Peptidase C39 family K06992 - - 0.000000000000000000000000000000000001239 151.0
HKD2_k127_4378931_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis K04479 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001561 332.0
HKD2_k127_4378931_1 protein serine/threonine phosphatase activity K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000005217 257.0
HKD2_k127_4378931_2 PA14 domain - GO:0005575,GO:0005576 - 0.0000000000000000000000000006521 121.0
HKD2_k127_4378931_3 Lamin Tail Domain - - - 0.0000000000000001236 86.0
HKD2_k127_4378931_4 Uncharacterized protein family UPF0016 - - - 0.0000000000001643 72.0
HKD2_k127_4378931_5 Protein of unknown function (DUF4064) - - - 0.0001398 49.0
HKD2_k127_4394529_0 4-Hydroxyphenylpyruvate dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006375 419.0
HKD2_k127_4394529_1 Spore germination protein K03294 - - 0.000000000000000000000000000000000000000000000000000001168 204.0
HKD2_k127_4394529_2 Protein of unknown function (DUF2769) - - - 0.00000000000000000000000009198 109.0
HKD2_k127_444785_0 AAA-like domain K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 498.0
HKD2_k127_444785_1 TGS domain protein K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 484.0
HKD2_k127_444785_10 KH domain protein K06961 - - 0.000000000000000000000000000000000000000000000000000000000000006826 221.0
HKD2_k127_444785_11 Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits K03236 - - 0.00000000000000000000000000000000000000008242 153.0
HKD2_k127_444785_12 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000004269 117.0
HKD2_k127_444785_2 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex K03546 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009942 426.0
HKD2_k127_444785_3 Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 379.0
HKD2_k127_444785_4 PFAM peptidase M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001044 374.0
HKD2_k127_444785_5 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 302.0
HKD2_k127_444785_6 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 - 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 287.0
HKD2_k127_444785_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004316 289.0
HKD2_k127_444785_8 serine threonine protein kinase K07178 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002924 265.0
HKD2_k127_444785_9 PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit K00441,K22174 - 1.1.98.4,1.12.98.1 0.0000000000000000000000000000000000000000000000000000000000000000000009655 250.0
HKD2_k127_4452355_0 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000001199 127.0
HKD2_k127_4452355_1 Alkyl sulfatase dimerisation - - - 0.000000000002118 71.0
HKD2_k127_4452355_2 Alkyl sulfatase dimerisation - - - 0.0005102 43.0
HKD2_k127_445668_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K06001 - 4.2.1.20 2.655e-213 670.0
HKD2_k127_445668_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 300.0
HKD2_k127_445668_2 Diacylglycerol kinase catalytic domain K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000001743 205.0
HKD2_k127_4476280_0 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 436.0
HKD2_k127_4476280_1 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.00000000000000000000000000000000000000000000000000000000003211 212.0
HKD2_k127_4476280_2 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000005061 190.0
HKD2_k127_4560983_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004582 482.0
HKD2_k127_4560983_1 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 390.0
HKD2_k127_4563950_0 Sodium Bile acid symporter family K03325 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 333.0
HKD2_k127_4563950_1 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000000000000000000000000000000005657 206.0
HKD2_k127_4563950_10 DGC domain - - - 0.00000000000000002559 85.0
HKD2_k127_4563950_11 cytochrome c biogenesis protein, transmembrane region K06196 - - 0.00000000001409 77.0
HKD2_k127_4563950_12 - - - - 0.0000000004533 64.0
HKD2_k127_4563950_2 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000001785 190.0
HKD2_k127_4563950_3 Predicted permease K07089 - - 0.0000000000000000000000000000000000000000000001021 171.0
HKD2_k127_4563950_4 helix_turn_helix, Arsenical Resistance Operon Repressor K21903 - - 0.0000000000000000000000000000000001543 136.0
HKD2_k127_4563950_5 Does not function as a glutathione-disulfide oxidoreductase in the presence of glutathione and glutathione reductase. Has low thioredoxin activity in vitro - - - 0.000000000000000000000001907 104.0
HKD2_k127_4563950_6 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000002553 106.0
HKD2_k127_4563950_7 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000002773 102.0
HKD2_k127_4563950_8 PFAM regulatory protein, ArsR K03892,K21903 - - 0.000000000000000001048 89.0
HKD2_k127_4563950_9 Sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.00000000000000002264 94.0
HKD2_k127_4594246_0 COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 - 0.00000000000000000000000000000000000003636 148.0
HKD2_k127_4594246_1 PFAM Lon protease (S16) C-terminal proteolytic domain K06870 - - 0.000000000000000000000004375 112.0
HKD2_k127_459917_0 PFAM aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006958 448.0
HKD2_k127_459917_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000002843 194.0
HKD2_k127_4604605_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 1.092e-262 823.0
HKD2_k127_4604605_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 2.39e-239 757.0
HKD2_k127_4604605_2 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 488.0
HKD2_k127_4604605_3 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.0000000000000000000000000000000000001048 144.0
HKD2_k127_4604605_4 PFAM TM2 domain containing protein K03686 - - 0.0000000000000000007453 89.0
HKD2_k127_4604605_5 transposase activity - - - 0.000000926 55.0
HKD2_k127_4604605_6 transposase activity - - - 0.00001866 48.0
HKD2_k127_4624175_0 DEAD DEAH box helicase domain protein K10896 - - 5.477e-228 728.0
HKD2_k127_4624175_1 Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys) K07587 - 6.1.1.27 2.628e-211 669.0
HKD2_k127_4624175_10 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.000000000000000000000000000000000000000000005372 169.0
HKD2_k127_4624175_11 - - - - 0.000000000000000001001 94.0
HKD2_k127_4624175_12 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00000000000000004175 84.0
HKD2_k127_4624175_13 CHAT domain - - - 0.0000000003282 74.0
HKD2_k127_4624175_14 Transposase domain (DUF772) K07481 - - 0.000000006681 57.0
HKD2_k127_4624175_15 RNA-binding protein of the translin family K07477 - - 0.00000002817 55.0
HKD2_k127_4624175_16 Transposase - - - 0.0000143 51.0
HKD2_k127_4624175_2 Archaeal Nre, N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 527.0
HKD2_k127_4624175_3 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000017 409.0
HKD2_k127_4624175_4 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001618 317.0
HKD2_k127_4624175_5 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000005303 267.0
HKD2_k127_4624175_6 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001888 265.0
HKD2_k127_4624175_7 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000007188 268.0
HKD2_k127_4624175_8 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000057 237.0
HKD2_k127_4624175_9 methyltransferase small K07579 - - 0.000000000000000000000000000000000000000000000000000004608 196.0
HKD2_k127_4625838_0 Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR) K00672 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.101 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001021 362.0
HKD2_k127_4625838_1 Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP K11176 - 3.5.4.10 0.000000000000000000000000000000000000000000007157 169.0
HKD2_k127_4628264_0 COG3547 Transposase and inactivated derivatives - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003432 309.0
HKD2_k127_4628264_1 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000111 258.0
HKD2_k127_4628264_2 - K00960 - 2.7.7.6 0.0000000000000008331 78.0
HKD2_k127_4628264_3 - - - - 0.0002323 46.0
HKD2_k127_4629585_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002659 401.0
HKD2_k127_4629585_1 histone deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008044 298.0
HKD2_k127_4629585_2 cell wall organization - - - 0.000000000002146 70.0
HKD2_k127_4629585_3 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0002544 44.0
HKD2_k127_4662643_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000001698 128.0
HKD2_k127_4662643_1 Hemerythrin HHE cation binding domain - - - 0.000000000000000002838 93.0
HKD2_k127_4662643_2 Chlorite dismutase - - - 0.0000000000000002669 82.0
HKD2_k127_4674313_0 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006229 336.0
HKD2_k127_4674313_1 Translation initiation factor 2 alpha subunit K03237 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 312.0
HKD2_k127_4674313_2 PAC2 family K07159 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 310.0
HKD2_k127_4674313_3 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000288 283.0
HKD2_k127_4674313_4 binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000001005 134.0
HKD2_k127_4674313_5 Ribosomal protein S27E K02978 - - 0.000000000000000003396 85.0
HKD2_k127_4674313_6 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000000001151 68.0
HKD2_k127_4674313_7 protein conserved in archaea K09723 - - 0.000000009119 59.0
HKD2_k127_4707587_0 nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004898 382.0
HKD2_k127_4707587_1 Flavodoxin - - - 0.0000000000000000000000001844 111.0
HKD2_k127_4802351_0 DNA ligase K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000002497 269.0
HKD2_k127_4802351_1 PFAM MazG nucleotide pyrophosphohydrolase - - - 0.0000002099 53.0
HKD2_k127_4810007_0 PFAM glycosyl transferase family 35 K00688 - 2.4.1.1 8.116e-289 908.0
HKD2_k127_4810007_1 Belongs to the carbohydrate kinase PfkB family. LacC subfamily K16370 - 2.7.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007608 343.0
HKD2_k127_4810007_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001258 283.0
HKD2_k127_4810007_3 NAD(P)H dehydrogenase (quinone) activity - - - 0.00000000000000000000000000000003027 133.0
HKD2_k127_4810007_4 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K16305 - 2.2.1.11,4.1.2.13 0.00000000001268 65.0
HKD2_k127_4814364_0 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003503 317.0
HKD2_k127_4814364_1 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000008334 239.0
HKD2_k127_4814364_2 PFAM Aminotransferase class I and II K04720 - 4.1.1.81 0.000000000000000000005194 96.0
HKD2_k127_4819805_0 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 520.0
HKD2_k127_4819805_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine K01778 - 5.1.1.7 0.000000000000000000000000000000000000000000000008068 176.0
HKD2_k127_4819805_2 Alcohol dehydrogenase GroES-like domain K00083 - 1.1.1.195 0.000000000004851 66.0
HKD2_k127_4839273_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004404 456.0
HKD2_k127_4839273_1 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000006702 179.0
HKD2_k127_4839273_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000001311 87.0
HKD2_k127_4839273_3 Glycogen debranching enzyme N terminal - - - 0.00000003681 56.0
HKD2_k127_5111860_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 406.0
HKD2_k127_5111860_1 PFAM PP-loop domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 295.0
HKD2_k127_5111860_2 Domain of unknown function (DUF1890) - - - 0.00000000000000000000000000000000000000000000000000001494 191.0
HKD2_k127_5111860_3 Domain of unknown function (DUF1894) - - - 0.000000000000000000000005133 104.0
HKD2_k127_5111860_4 Elongator protein 3 MiaB NifB - - - 0.0000000001515 61.0
HKD2_k127_5111860_5 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.0000002526 55.0
HKD2_k127_5131310_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 505.0
HKD2_k127_5131310_1 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 289.0
HKD2_k127_5131310_2 TIGRFAM archaeoflavoprotein AfpA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009054 246.0
HKD2_k127_5131310_3 Isoprenylcysteine carboxyl methyltransferase - - - 0.00000009169 56.0
HKD2_k127_5133878_0 PFAM phosphoesterase, RecJ domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005332 346.0
HKD2_k127_5133878_1 able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000000000000007114 138.0
HKD2_k127_5133878_2 ribosomal protein S15 K02956 - - 0.000000000000000000000000003081 114.0
HKD2_k127_5133878_3 - - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464 - 0.00000006674 57.0
HKD2_k127_5142840_0 Carbamoyl-phosphate synthetase large chain, oligomerisation K01955 - 6.3.5.5 6.875e-312 964.0
HKD2_k127_517403_0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002824 512.0
HKD2_k127_517403_1 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 357.0
HKD2_k127_517403_10 TIGRFAM alkylhydroperoxidase like protein, AhpD family - - - 0.0008326 44.0
HKD2_k127_517403_2 Copper amine oxidase N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003212 261.0
HKD2_k127_517403_3 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004909 242.0
HKD2_k127_517403_4 Domain of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000006221 225.0
HKD2_k127_517403_5 binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000001107 215.0
HKD2_k127_517403_6 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000004876 171.0
HKD2_k127_517403_7 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000001959 166.0
HKD2_k127_517403_8 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000000009803 109.0
HKD2_k127_517403_9 transcription initiation from RNA polymerase II promoter - - - 0.0002177 44.0
HKD2_k127_5190803_0 PFAM Acetyl-CoA hydrolase transferase K18122 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 347.0
HKD2_k127_5190803_1 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 - 2.1.1.215,2.1.1.216 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002566 316.0
HKD2_k127_5190803_2 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000003022 239.0
HKD2_k127_5190803_3 Histone deacetylase domain - - - 0.000000000000000000000000000000000000001565 154.0
HKD2_k127_5190803_4 Acetyl-CoA hydrolase/transferase C-terminal domain - - - 0.0000000000000000000000000000000009364 132.0
HKD2_k127_5190803_5 acetyl-CoA hydrolase transferase - - - 0.000000000000000000002863 96.0
HKD2_k127_5190803_6 TIGRFAM TraB family protein - - - 0.00000000003237 64.0
HKD2_k127_5248749_0 PFAM extracellular solute-binding protein family 3 K02030 - - 0.00000000000000000000000000000000000000000000000000000000000001416 224.0
HKD2_k127_5262602_0 PFAM NADH Ubiquinone plastoquinone (complex I) K05568,K12137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 593.0
HKD2_k127_5262602_1 Proton-conducting membrane transporter K05568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 508.0
HKD2_k127_5262602_2 Proton-conducting membrane transporter K05568 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 475.0
HKD2_k127_5262602_3 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K05567 - - 0.0000000000000000756 82.0
HKD2_k127_5262602_4 - - - - 0.000007137 53.0
HKD2_k127_5262602_5 Universal stress protein family - - - 0.00001259 51.0
HKD2_k127_5266204_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - 1.45e-321 1008.0
HKD2_k127_5266204_1 nicotinamidase activity - GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008936,GO:0009117,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019362,GO:0019637,GO:0019674,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901360,GO:1901564 - 0.000000000000000000000000000000000000000000000001247 181.0
HKD2_k127_5266204_2 PFAM Radical SAM domain protein - - - 0.000000000000000000000000000000000000000000001548 171.0
HKD2_k127_5266204_3 Protein of unknown function (DUF3467) - - - 0.0000000000000000000000000001935 118.0
HKD2_k127_5266204_4 - - - - 0.000000000000000002529 89.0
HKD2_k127_5266204_5 MacB-like periplasmic core domain K09808 - - 0.0000000004006 64.0
HKD2_k127_5288554_0 Sulfate permease K03321 - - 0.00000000000000000000000000000000000000000000000000000000000006975 223.0
HKD2_k127_5288554_1 Sulfate permease K03321 - - 0.000000000000000000000000000000000000000000000000007624 188.0
HKD2_k127_5288554_2 Sulfate permease family K03321 - - 0.000008642 52.0
HKD2_k127_5304882_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002407 317.0
HKD2_k127_5304882_1 Involved in the catabolism of quinolinic acid (QA) K00767 - 2.4.2.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004779 290.0
HKD2_k127_5304882_2 Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate K06989 - 1.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000004054 260.0
HKD2_k127_5304882_3 Periplasmic copper-binding protein (NosD) K07218 - - 0.00000000002008 76.0
HKD2_k127_5308047_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 402.0
HKD2_k127_5308047_1 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000003712 213.0
HKD2_k127_5308047_2 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000001351 209.0
HKD2_k127_5308047_3 Chlorite dismutase - - - 0.000001919 51.0
HKD2_k127_5308047_4 Chlorite dismutase - - - 0.000002392 52.0
HKD2_k127_5346208_0 UV-endonuclease UvdE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 340.0
HKD2_k127_5346208_1 Protein of unknown function (DUF1722) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000762 240.0
HKD2_k127_5351233_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000024 287.0
HKD2_k127_5351233_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K11527 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004911 293.0
HKD2_k127_5376156_0 DNA polymerase K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002719 541.0
HKD2_k127_5376156_1 Histidine kinase K14978 - - 0.00003329 51.0
HKD2_k127_5396758_0 - - - - 0.000000000000000002809 87.0
HKD2_k127_5396758_1 Belongs to the 'phage' integrase family K04763 - - 0.00000001552 59.0
HKD2_k127_5396758_2 Response regulator receiver - - - 0.0002511 49.0
HKD2_k127_5400477_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 434.0
HKD2_k127_5400477_1 Pfam:DUF137 K09722 - 6.3.2.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 307.0
HKD2_k127_5400477_2 PFAM GHMP kinase K06982 - 2.7.1.169 0.000000000000000000000000000000000000000000000000000000000000000001865 236.0
HKD2_k127_5400477_3 eRF1 domain 2 - - - 0.00000000000000000000000009078 118.0
HKD2_k127_5400477_4 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000003696 79.0
HKD2_k127_5404693_0 PFAM ABC transporter K00400 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007823 564.0
HKD2_k127_5404693_1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K22161 - 1.5.98.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000286 451.0
HKD2_k127_5404693_2 Component of the F(420)H(2) dehydrogenase (FPO complex) which is part of the energy-conserving F(420)H(2) heterodisulfide oxidoreductase system. The membrane-bound electron transfer system of the complex plays an important role in the metabolism of methylotrophic methanogens when the organisms grow on methanol or methylamines. Catalyzes the oxidation of methanophenazine to dihydromethanophenazine. It shuttles electrons from F(420)H(2), via FAD and iron-sulfur (Fe-S) centers, to methanophenazine (an electron carrier in the membrane). It couples the redox reaction to proton translocation (for every two electrons transferred, two hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00337,K22163 - 1.5.98.3,1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 338.0
HKD2_k127_5404693_3 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 328.0
HKD2_k127_5404693_4 NADH ubiquinone oxidoreductase, 20 Kd subunit K22159 - 1.5.98.3 0.00000000000000000000000000000000000000000000000000000000000000000002859 239.0
HKD2_k127_5404693_5 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000002113 222.0
HKD2_k127_5404693_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000006173 111.0
HKD2_k127_5404693_7 4Fe-4S dicluster domain K00338 - 1.6.5.3 0.000000000000000002939 88.0
HKD2_k127_5419925_0 transcription activator, effector binding - - - 0.00000000000000000000000000000000000000004179 156.0
HKD2_k127_5419925_1 Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency K06928 - 3.6.1.15 0.00000000000000000000000000000000000000006927 157.0
HKD2_k127_5419925_2 membrane protein (DUF2207) - - - 0.00000000000000000000000000000000000000009771 159.0
HKD2_k127_5419925_3 PFAM TM2 domain containing protein K03686 - - 0.0000000000000000002394 91.0
HKD2_k127_5428840_0 TIGRFAM transposase, IS605 OrfB family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005811 299.0
HKD2_k127_5428840_1 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.00000001443 63.0
HKD2_k127_5429202_0 Belongs to the glutamate synthase family K00265 - 1.4.1.13,1.4.1.14 1.592e-249 777.0
HKD2_k127_5429202_1 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 469.0
HKD2_k127_5429202_2 GXGXG motif - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009014 316.0
HKD2_k127_5429202_3 L-glutamate biosynthetic process - - - 0.00009728 45.0
HKD2_k127_5438165_0 Belongs to the peptidase M48B family K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 367.0
HKD2_k127_5438165_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000007725 235.0
HKD2_k127_5438165_2 nuclease - - - 0.0001425 47.0
HKD2_k127_5442138_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 438.0
HKD2_k127_5442138_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000496 269.0
HKD2_k127_5442138_2 Protein of unknown function (DUF1699) - - - 0.00000000000000000000000000000000000000001323 156.0
HKD2_k127_5442138_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000575 90.0
HKD2_k127_5442138_4 Belongs to the acylphosphatase family K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.00000000000000000187 87.0
HKD2_k127_5478034_0 PFAM peptidase M50 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004557 356.0
HKD2_k127_5478034_1 H4MPT-linked C1 transfer pathway protein K07072 - 2.5.1.131 0.0000000006782 63.0
HKD2_k127_5497972_0 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001513 506.0
HKD2_k127_5497972_1 Met-10+ like-protein K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000003667 260.0
HKD2_k127_5497972_2 Possible catecholamine-binding domain present in a variety of eukaryotic proteins. - - - 0.0000000000000000000000000000000000000000000000000001708 199.0
HKD2_k127_5497972_3 Uncharacterized protein domain (DUF2202) - - - 0.00000000000000000000000000000000000000007405 165.0
HKD2_k127_5497972_4 COG2041 Sulfite oxidase and related enzymes - - - 0.000000000008716 68.0
HKD2_k127_5503040_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004931 527.0
HKD2_k127_5503040_1 PFAM Oligosaccharyl transferase STT3 subunit K07151 - 2.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007331 469.0
HKD2_k127_5503040_2 phenylalanyl-tRNA synthetase beta subunit K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001289 368.0
HKD2_k127_5503040_3 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000000000000000003267 204.0
HKD2_k127_550735_0 Cell division protein 48 (CDC48), domain 2 K13525 - - 2.059e-316 982.0
HKD2_k127_550735_1 PFAM dihydropteroate synthase, DHPS K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 314.0
HKD2_k127_550735_2 ATPases associated with a variety of cellular activities K09817 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004346 275.0
HKD2_k127_550735_3 TIGRFAM F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005471 272.0
HKD2_k127_550735_4 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004144 249.0
HKD2_k127_550735_5 ABC-3 protein K09816 - - 0.0000000000000000000000000000000000000000000000000000000000000000001382 238.0
HKD2_k127_550735_6 domain protein K01992,K06994 - - 0.0000000000000000000000000000000000000000000000000000001754 205.0
HKD2_k127_550735_7 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000000000000005069 133.0
HKD2_k127_550735_8 extracellular matrix structural constituent - - - 0.000000009395 66.0
HKD2_k127_5518879_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 1.18e-237 762.0
HKD2_k127_5518879_1 Pyridine nucleotide-disulphide oxidoreductase K07137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003835 588.0
HKD2_k127_5518879_10 TIGRFAM molybdenum cofactor synthesis domain K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000000126 175.0
HKD2_k127_5518879_11 Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes K03136 - - 0.00000000000000000000000000000000000000000003628 166.0
HKD2_k127_5518879_12 TPR Domain containing protein - - - 0.0000000000000000000000000000000000000000002917 167.0
HKD2_k127_5518879_13 Major facilitator superfamily - - - 0.00000000000000000000000000000000007002 148.0
HKD2_k127_5518879_14 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.00000000000000000000000000000003736 126.0
HKD2_k127_5518879_15 Transcriptional regulator, TrmB - - - 0.00000000000000000000000001214 114.0
HKD2_k127_5518879_16 Protein of unknown function (DUF2551) - - - 0.00000000000000000003841 94.0
HKD2_k127_5518879_17 peptidyl-tyrosine sulfation - - - 0.0000000000000004062 82.0
HKD2_k127_5518879_18 Lrp/AsnC ligand binding domain - - - 0.00000000000002089 76.0
HKD2_k127_5518879_2 PFAM AIR synthase related protein K07388 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007107 555.0
HKD2_k127_5518879_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005543 329.0
HKD2_k127_5518879_4 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005997 320.0
HKD2_k127_5518879_5 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 294.0
HKD2_k127_5518879_6 Hit family K19710 - 2.7.7.53 0.000000000000000000000000000000000000000000000000000000000000000001981 229.0
HKD2_k127_5518879_7 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function K15904 - 2.3.1.234,2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000001616 224.0
HKD2_k127_5518879_8 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000002343 200.0
HKD2_k127_5518879_9 - - - - 0.000000000000000000000000000000000000000000000000007846 183.0
HKD2_k127_5531218_0 Formate dehydrogenase alpha subunit K00123,K05299,K22341 - 1.17.1.10,1.17.1.11,1.17.1.9 3.207e-235 744.0
HKD2_k127_5531218_1 4Fe-4S dicluster domain - - - 0.00000000001036 70.0
HKD2_k127_5583245_0 PFAM Pyridoxal-dependent decarboxylase - - - 0.000000000000000000000000000000009148 130.0
HKD2_k127_5583245_1 COGs COG0076 Glutamate decarboxylase and related PLP-dependent protein - - - 0.00000000001378 67.0
HKD2_k127_5583245_2 peroxiredoxin activity K03386 - 1.11.1.15 0.0008703 43.0
HKD2_k127_5593117_0 sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000001711 121.0
HKD2_k127_5635822_0 - - - - 0.0000000000000000000000000000000000000000000002882 170.0
HKD2_k127_5649960_0 ATP-dependent helicase nuclease subunit A K16898 - 3.6.4.12 0.00000284 54.0
HKD2_k127_5740963_0 PspA/IM30 family K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007905 264.0
HKD2_k127_5740963_1 TPR repeat-containing protein - - - 0.00000000000000000000000000000000000001007 161.0
HKD2_k127_5740963_2 - - - - 0.0000000000000000000000002714 107.0
HKD2_k127_5785522_0 Cell division protein 48 (CDC48) domain 2 K13525 - - 0.0 1010.0
HKD2_k127_5785522_1 Cys/Met metabolism PLP-dependent enzyme K01758,K01761 - 4.4.1.1,4.4.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 474.0
HKD2_k127_5785522_2 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000000000000000000000000000000000000000000000000008456 237.0
HKD2_k127_5785522_3 PFAM triphosphoribosyl-dephospho-CoA protein K05966 - 2.4.2.52 0.00000000000000000000000000000000000000000000000000000006485 205.0
HKD2_k127_5785522_4 Dihydrouridine synthase (Dus) - - - 0.00000000000000000000000000000000000000000000000000001746 207.0
HKD2_k127_5785522_5 Protein of unknown function (DUF447) K09154 - - 0.00000000000000000000000000004781 125.0
HKD2_k127_5785522_6 TIGRFAM ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000001115 118.0
HKD2_k127_5785522_7 Hemerythrin HHE cation binding K07322 - - 0.0000000000000000000001463 100.0
HKD2_k127_5785522_8 Belongs to the 'phage' integrase family - - - 0.00002748 51.0
HKD2_k127_5788480_0 Serine dehydrogenase proteinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006744 351.0
HKD2_k127_5788480_1 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000369 309.0
HKD2_k127_5788480_2 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004277 297.0
HKD2_k127_5788480_3 Methyltransferase K15429 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000002906 223.0
HKD2_k127_5788480_4 - - - - 0.0000000000000000000000000000000000000000001826 172.0
HKD2_k127_5788480_5 Thioredoxin K03671 - - 0.0000000000000000000000000000000000000006388 152.0
HKD2_k127_5788480_6 Protein of unknown function (DUF1638) - - - 0.00000000000000000000000000000003894 132.0
HKD2_k127_5792227_0 PFAM Cation K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008475 416.0
HKD2_k127_5792227_1 cellular potassium ion transport K03499 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 376.0
HKD2_k127_5792227_2 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006216,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009972,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042454,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 3.5.4.5 0.0000000000000000000000000002069 117.0
HKD2_k127_5797896_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009195 553.0
HKD2_k127_5797896_1 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 338.0
HKD2_k127_5797896_2 Uncharacterized protein conserved in archaea (DUF2121) - - - 0.0000000000000000217 89.0
HKD2_k127_5797896_3 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752,K13818 - 2.7.7.77 0.00000000000000008374 84.0
HKD2_k127_5797896_4 PFAM PUA domain containing protein K07398 - - 0.0000000000009776 70.0
HKD2_k127_5814821_0 PFAM Pyruvate kinase, alpha beta domain K09126 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009273 281.0
HKD2_k127_5814821_1 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008942 244.0
HKD2_k127_5814821_2 PFAM PEBP family protein K06910 - - 0.0000000000000000000000000000000000000000000002513 172.0
HKD2_k127_5866563_0 Metallo-beta-lactamase superfamily K07577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009641 326.0
HKD2_k127_5866563_1 SMART Elongator protein 3 MiaB NifB K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 317.0
HKD2_k127_5866563_2 SMART regulatory protein AsnC Lrp family K22225 - - 0.00000000000000000000000000000000000000003949 157.0
HKD2_k127_5866563_3 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.0000000000000000000000000000000000000001807 153.0
HKD2_k127_5866563_4 Belongs to the eukaryotic ribosomal protein eL18 family K02883 - - 0.000000000000000000000000000000000003709 140.0
HKD2_k127_5866563_5 COG0526 Thiol-disulfide isomerase and thioredoxins K03671 - - 0.0000000000000000001405 91.0
HKD2_k127_5866563_6 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000001151 68.0
HKD2_k127_5895447_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004997 576.0
HKD2_k127_5895447_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 464.0
HKD2_k127_5895447_2 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773,K18779 - 2.4.2.29,2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000009067 239.0
HKD2_k127_5895447_3 permease - - - 0.0000021 59.0
HKD2_k127_5896366_0 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 534.0
HKD2_k127_5896366_1 Galactose-1-phosphate uridyl transferase, N-terminal domain K00965 - 2.7.7.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006542 286.0
HKD2_k127_5896366_2 Pfam:UPF0118 - - - 0.00000000000000000000000000000000000000000000000000000003323 209.0
HKD2_k127_5896366_3 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.0009976 49.0
HKD2_k127_592052_0 - K00960 - 2.7.7.6 0.000000000000001359 78.0
HKD2_k127_592052_1 Bacterial regulatory protein, arsR family - - - 0.000000000000002389 79.0
HKD2_k127_592052_2 DNA polymerase activity K02319 - 2.7.7.7 0.0001028 47.0
HKD2_k127_5936230_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 378.0
HKD2_k127_5936230_1 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.00000000000000000000000000000000000000000002417 168.0
HKD2_k127_5936230_2 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000001561 169.0
HKD2_k127_5936230_3 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000001517 134.0
HKD2_k127_5936230_4 protein conserved in archaea - - - 0.0000000000000000000000000004665 116.0
HKD2_k127_5936230_5 Transcriptional regulator, TrmB - - - 0.000000000000000000000000005049 115.0
HKD2_k127_5974118_0 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 585.0
HKD2_k127_6032075_0 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 7.429e-198 626.0
HKD2_k127_6032075_1 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 438.0
HKD2_k127_6032075_2 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.00000000000000000000000000003432 118.0
HKD2_k127_6032075_3 - - - - 0.000000000493 66.0
HKD2_k127_6032075_4 Zn-ribbon containing protein K07163 - - 0.0000000007025 64.0
HKD2_k127_6032075_5 Mo-molybdopterin cofactor metabolic process K03753 - - 0.00001213 51.0
HKD2_k127_6045681_0 COGs COG1961 Site-specific recombinase DNA invertase Pin homologs K06400 - - 0.0000000000000000000000008884 109.0
HKD2_k127_6045681_1 - K01489 - 3.5.4.5 0.000000000000001142 80.0
HKD2_k127_605006_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000002416 239.0
HKD2_k127_605006_1 RimK domain protein ATP-grasp K05844,K15740 - 6.3.2.33 0.00000000000000000000000000000000000000000000000000000000000001647 225.0
HKD2_k127_6095566_0 DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000517 514.0
HKD2_k127_6095566_1 homoserine dehydrogenase K00003 - 1.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005923 341.0
HKD2_k127_6095566_2 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000012 246.0
HKD2_k127_6095566_3 amino acid-binding ACT domain protein - - - 0.00000000000000000000000000000000000000000000000000000000789 203.0
HKD2_k127_6101845_0 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005196 501.0
HKD2_k127_6101845_1 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 321.0
HKD2_k127_6101845_10 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000005978 145.0
HKD2_k127_6101845_11 Universal stress protein family - - - 0.000000000000000000000000000000003781 133.0
HKD2_k127_6101845_2 UbiA prenyltransferase family K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 312.0
HKD2_k127_6101845_3 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 297.0
HKD2_k127_6101845_4 Fe-S type, tartrate fumarate subfamily, alpha K01677 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001061 280.0
HKD2_k127_6101845_5 PFAM Glucose-6-phosphate isomerase K06859 - 5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002991 271.0
HKD2_k127_6101845_6 PFAM bifunctional deaminase-reductase domain protein K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000000000000003842 237.0
HKD2_k127_6101845_7 Domain of unknown function - - - 0.000000000000000000000000000000000000000000000000000000000000000000643 237.0
HKD2_k127_6101845_8 Fumarase C-terminus K01678 - 4.2.1.2 0.00000000000000000000000000000000000000000000000006038 183.0
HKD2_k127_6101845_9 Protein of unknown function (DUF434) - - - 0.0000000000000000000000000000000000000002281 157.0
HKD2_k127_6132871_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006687 524.0
HKD2_k127_6132871_1 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 365.0
HKD2_k127_6132871_10 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.000000000000000000000000000000005627 133.0
HKD2_k127_6132871_11 binds to the 23S rRNA K02921 - - 0.00000000000000000000000000003328 118.0
HKD2_k127_6132871_12 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.00000000000000000000000005784 113.0
HKD2_k127_6132871_13 RNA binding K07581 - - 0.00000000000000000000001325 107.0
HKD2_k127_6132871_14 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.00000000000000000002038 90.0
HKD2_k127_6132871_15 protein conserved in archaea K09741 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 - 0.000002042 52.0
HKD2_k127_6132871_16 Predicted RNA-binding protein - - - 0.00009953 48.0
HKD2_k127_6132871_2 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 338.0
HKD2_k127_6132871_3 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004816 338.0
HKD2_k127_6132871_4 PFAM Shwachman-Bodian-Diamond syndrome K14574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001334 323.0
HKD2_k127_6132871_5 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003253 281.0
HKD2_k127_6132871_6 Belongs to the eukaryotic ribosomal protein eL15 family K02877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003163 262.0
HKD2_k127_6132871_7 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000479 254.0
HKD2_k127_6132871_8 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000000000000000000000000002635 187.0
HKD2_k127_6132871_9 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03539 - 3.1.26.5 0.0000000000000000000000000000000000001211 150.0
HKD2_k127_6169011_0 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009112 575.0
HKD2_k127_6169011_1 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000008078 228.0
HKD2_k127_6169011_2 aspartate glutamate uridylate kinase K07144 - 2.7.4.31 0.000000000000000000000000000000000000000000181 166.0
HKD2_k127_6169011_3 NUDIX domain K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000317 160.0
HKD2_k127_6169011_4 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.00000000000000000000000000000000000000008773 167.0
HKD2_k127_6169011_5 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000001412 113.0
HKD2_k127_6169011_6 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000000000000009225 92.0
HKD2_k127_6169011_7 Domain of unknown function (DUF1610) K07580 - - 0.0000000000000001237 81.0
HKD2_k127_6169011_8 transcription initiation from RNA polymerase II promoter - - - 0.000009839 48.0
HKD2_k127_6169011_9 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.0000151 51.0
HKD2_k127_6182282_0 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002027 488.0
HKD2_k127_6182282_1 NADPH-dependent FMN reductase - - - 0.00000000000000000008351 90.0
HKD2_k127_6182282_2 Protein of unknown function (DUF763) K09003 - - 0.000000000001772 68.0
HKD2_k127_6228054_0 Transposase domain (DUF772) K07481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003821 364.0
HKD2_k127_6228054_1 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase - - - 0.000000001443 67.0
HKD2_k127_6250800_0 alpha/beta hydrolase fold - GO:0003674,GO:0003824,GO:0016787 - 0.0000000000000000000000000000000000000000000000000000000006372 213.0
HKD2_k127_6250800_1 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000002606 200.0
HKD2_k127_6250800_2 membrane - - - 0.0000000000000000000000000000000000001366 151.0
HKD2_k127_6250800_3 Phosphoesterase - - - 0.0000000000000000000003779 100.0
HKD2_k127_6250800_4 RDD family - - - 0.00000000000000000006211 95.0
HKD2_k127_6250800_5 Protein of unknown function (DUF998) - - - 0.00000002429 57.0
HKD2_k127_6259103_0 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 1.191e-212 670.0
HKD2_k127_6259103_1 Protein of unknown function (DUF1699) - - - 0.0000000000000000000000000000000000000866 146.0
HKD2_k127_6259103_2 Belongs to the GcvT family K00302 - 1.5.3.1 0.000005206 49.0
HKD2_k127_6276553_0 Domain of unknown function (DUF4277) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 432.0
HKD2_k127_6276553_1 COGs COG5421 Transposase - - - 0.000000000000000007216 86.0
HKD2_k127_6332766_0 PFAM metal-dependent phosphohydrolase, HD sub domain K06885 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 396.0
HKD2_k127_6332766_1 PFAM Phosphomethylpyrimidine kinase type-1 K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 317.0
HKD2_k127_6332766_2 Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit K08264 GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576 1.8.98.1 0.00000000000000000000000000113 116.0
HKD2_k127_6332766_3 Belongs to the UPF0216 family K09737 - - 0.0000000000000000009365 91.0
HKD2_k127_6398422_0 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001719 466.0
HKD2_k127_6398422_1 PFAM Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000001695 216.0
HKD2_k127_6398422_2 Methanogenesis marker protein 8 - - - 0.000000000000000000000000000000000000000000000000000001063 202.0
HKD2_k127_6398422_3 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000002023 175.0
HKD2_k127_6398422_4 TIGRFAM DJ-1 family protein K03152 - 3.5.1.124 0.000000000000000000000000000000000000000000004188 169.0
HKD2_k127_6398422_5 Transposase domain (DUF772) K07481 - - 0.000000000000000000002379 98.0
HKD2_k127_6398422_6 Transposase domain (DUF772) K07481 - - 0.0000000000000001001 82.0
HKD2_k127_6410699_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1235.0
HKD2_k127_6410699_1 Oxidoreductase FAD-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001866 263.0
HKD2_k127_6410699_2 LUD domain - - - 0.0000000000000000000000000000000000000000000000000000000000001776 218.0
HKD2_k127_6410699_3 Belongs to the rubredoxin family - GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114 - 0.000000000000000007957 85.0
HKD2_k127_6410699_4 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.2.1.59 0.0000002296 60.0
HKD2_k127_6443896_0 Uncharacterized conserved protein (DUF2299) - - - 0.0000000000000000000000000000000000000000004911 162.0
HKD2_k127_6443896_1 - - - - 0.000006372 58.0
HKD2_k127_6443896_2 Phage plasmid primase, P4 family K06919 - - 0.000006607 51.0
HKD2_k127_6443896_3 DDE superfamily endonuclease - - - 0.000007562 48.0
HKD2_k127_6443938_0 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008586 394.0
HKD2_k127_6443938_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.000000000000000000000000000000000000000000000000000000000000002791 222.0
HKD2_k127_6443938_2 Integral membrane protein DUF106 - - - 0.0000000000000000000000000000000000000000000000000131 187.0
HKD2_k127_6443938_3 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.00000000000000000000000000000000000004662 148.0
HKD2_k127_6443938_4 DDE superfamily endonuclease - - - 0.000007562 48.0
HKD2_k127_6443938_5 Chagasin family peptidase inhibitor I42 K14475 - - 0.0009509 49.0
HKD2_k127_6445752_0 transposase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 439.0
HKD2_k127_6445752_1 Domain of unknown function (DUF296) K06934 - - 0.0000000000000000000000000000000000000000006409 161.0
HKD2_k127_6445752_2 uncharacterised conserved protein UCP017998 - - - 0.000000000000000000000003305 113.0
HKD2_k127_6445752_3 Phage integrase, N-terminal SAM-like domain K04763 - - 0.0004888 47.0
HKD2_k127_6449887_0 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000422 280.0
HKD2_k127_6449887_1 PFAM formylmethanofuran dehydrogenase, subunit E region K11261 - 1.2.7.12 0.000000000000000000000000000000000000000003329 156.0
HKD2_k127_6449887_2 Catalyzes the insertion of Co(2 ) into sirohydrochlorin K02190 - 4.99.1.3 0.0000000000000000000000001005 113.0
HKD2_k127_6449887_3 PFAM formylmethanofuran dehydrogenase, subunit E region K11261 - 1.2.7.12 0.000000000000000000001168 97.0
HKD2_k127_6449887_4 Domain of unknown function (DUF362) - - - 0.0000000000003406 78.0
HKD2_k127_6460701_0 phosphoserine phosphatase SerB K01079 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007696 396.0
HKD2_k127_6460701_1 cytidyltransferase-related domain K00952 - 2.7.7.1 0.000000000000000000000000000000000000000000000000000000002387 203.0
HKD2_k127_6460701_2 May be involved in maturation of the 30S ribosomal subunit K02966 - - 0.0000000000000000000000000000000000000000000000003313 181.0
HKD2_k127_6460701_3 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.00000000000000000000000000000000000000000000002109 173.0
HKD2_k127_6460701_4 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.00000000000000000000000000000000000000006018 156.0
HKD2_k127_6460701_5 Belongs to the PDCD5 family K06875 - - 0.00000000000000000000000005289 111.0
HKD2_k127_6467969_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 1.505e-201 639.0
HKD2_k127_6467969_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 572.0
HKD2_k127_6467969_10 Rhomboid family K07059 - - 0.000000000000000000000000000000003377 138.0
HKD2_k127_6467969_11 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000008904 97.0
HKD2_k127_6467969_12 Epidermal growth factor-like domain. - GO:0002009,GO:0002165,GO:0003674,GO:0005198,GO:0005201,GO:0005575,GO:0005576,GO:0007275,GO:0007424,GO:0007444,GO:0007472,GO:0007475,GO:0007476,GO:0007552,GO:0007560,GO:0007591,GO:0008150,GO:0008362,GO:0008587,GO:0009653,GO:0009791,GO:0009886,GO:0009887,GO:0009888,GO:0022404,GO:0031012,GO:0032501,GO:0032502,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0040003,GO:0040005,GO:0042303,GO:0042335,GO:0044421,GO:0044719,GO:0048513,GO:0048563,GO:0048569,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048856,GO:0060429,GO:0060541,GO:0060562,GO:0065007,GO:0065008,GO:0090066 - 0.00004934 54.0
HKD2_k127_6467969_2 NADH:flavin oxidoreductase / NADH oxidase family K10680 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001854 506.0
HKD2_k127_6467969_3 AAA-like domain K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003445 494.0
HKD2_k127_6467969_4 PFAM Aldehyde dehydrogenase K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006217 468.0
HKD2_k127_6467969_5 Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P) K09733 - 4.2.3.153 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008852 296.0
HKD2_k127_6467969_6 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002213 281.0
HKD2_k127_6467969_7 NYN domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001664 241.0
HKD2_k127_6467969_8 Peptidyl-prolyl cis-trans K03775 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000008446 196.0
HKD2_k127_6467969_9 PFAM PEBP family protein K06910 - - 0.000000000000000000000000000000000000000000000003466 176.0
HKD2_k127_6490583_0 acetyltransferase - - - 0.0000000000000000000000000000003918 130.0
HKD2_k127_6490583_1 - - - - 0.000000000000001962 83.0
HKD2_k127_6521803_0 ABC-type metal ion transport system periplasmic component surface adhesin K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008032 244.0
HKD2_k127_6521803_1 Putative zinc ribbon domain - - - 0.000000000000000005787 86.0
HKD2_k127_6521803_2 SPFH Band 7 PHB domain protein - - - 0.0000000000000007242 87.0
HKD2_k127_6554523_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1090.0
HKD2_k127_6554523_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 530.0
HKD2_k127_6554523_2 Histone deacetylase domain K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003263 272.0
HKD2_k127_6554523_3 SMART Peptidase A22, presenilin signal peptide - - - 0.00000000000000000000000000000000000000000000000000000000000000000000011 250.0
HKD2_k127_6554523_4 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.0000000000000000000000000000000000000000000000000004315 189.0
HKD2_k127_6554523_5 PFAM Adenylate cyclase K05873 GO:0003674,GO:0003824,GO:0004016,GO:0009975,GO:0016829,GO:0016849 4.6.1.1 0.000000000000000000000000000000001948 138.0
HKD2_k127_6554523_6 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000001749 89.0
HKD2_k127_6554523_7 S-layer protein - - - 0.000000000000006906 82.0
HKD2_k127_6557258_0 Belongs to the HisA HisF family K01814 - 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000138 205.0
HKD2_k127_6557258_1 YEATS family - - - 0.0001275 51.0
HKD2_k127_6589361_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 - 6.3.5.7 8.102e-219 695.0
HKD2_k127_6589361_1 PFAM aminoacyl-tRNA synthetase class Ib K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 534.0
HKD2_k127_6589361_10 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.0000000000000000000000000000000000000000008787 160.0
HKD2_k127_6589361_11 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000003274 105.0
HKD2_k127_6589361_12 COG3634 Alkyl hydroperoxide reductase, large subunit - - - 0.000000000000000003056 86.0
HKD2_k127_6589361_13 Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation - - - 0.0000000000000003206 80.0
HKD2_k127_6589361_2 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003366 431.0
HKD2_k127_6589361_3 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 428.0
HKD2_k127_6589361_4 PFAM amino acid-binding ACT domain protein K06862 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 307.0
HKD2_k127_6589361_5 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003963 299.0
HKD2_k127_6589361_6 Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication K04802 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 290.0
HKD2_k127_6589361_7 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001985 254.0
HKD2_k127_6589361_8 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000004291 244.0
HKD2_k127_6589361_9 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000005469 209.0
HKD2_k127_6603747_0 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000001629 143.0
HKD2_k127_6603747_1 PFAM molybdopterin biosynthesis MoaE K03635,K21142 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 0.000000000000000000000000000000001233 134.0
HKD2_k127_6603747_2 PFAM CutA1 divalent ion tolerance protein K03926 - - 0.0000000000000000000001102 102.0
HKD2_k127_6603747_4 membrane protein of uknown function UCP014873 - - - 0.0004631 45.0
HKD2_k127_6605104_0 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007908 312.0
HKD2_k127_6605104_1 membrane - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004677 273.0
HKD2_k127_6605104_2 PFAM Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000001592 222.0
HKD2_k127_660661_0 Prismane/CO dehydrogenase family K00198 - 1.2.7.4 1.091e-229 719.0
HKD2_k127_660661_1 Protein of unknown function (DUF521) K09123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000257 447.0
HKD2_k127_660661_2 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000015 330.0
HKD2_k127_660661_3 methyltransferase activity K00577 - 2.1.1.86 0.00000000000000000000000000000000000000000000000000002471 194.0
HKD2_k127_660661_4 4Fe-4S dicluster domain K00196 - - 0.000000000000000000000000000000000000000000000000218 182.0
HKD2_k127_660661_5 PFAM GvpD gas vesicle - - - 0.000000000000000000000000000000000000000000000001418 190.0
HKD2_k127_660661_6 Belongs to the UPF0107 family K09128 - - 0.0000000000000000000000000000000000000009999 151.0
HKD2_k127_660661_7 Pas domain - - - 0.00001155 52.0
HKD2_k127_6658508_0 NADH dehydrogenase K03885 - 1.6.99.3 0.00000000000005012 80.0
HKD2_k127_6659720_0 malic enzyme K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003841 500.0
HKD2_k127_6659720_1 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005194 464.0
HKD2_k127_6659720_10 phosphoesterase RecJ domain protein K15986 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006126 284.0
HKD2_k127_6659720_11 PFAM Methyl-coenzyme M reductase operon protein C K03421 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001268 274.0
HKD2_k127_6659720_12 Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) K07142 - 2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000000001204 251.0
HKD2_k127_6659720_13 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.000000000000000000000000000000000000000000000000506 183.0
HKD2_k127_6659720_14 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.000000000000000000000000000000000000000000000005449 175.0
HKD2_k127_6659720_15 Uncharacterized protein conserved in archaea (DUF2150) - - - 0.00000000000000000000000000000000000000000000008591 175.0
HKD2_k127_6659720_16 PFAM thymidylate kinase K00943 - 2.7.4.9 0.000000000000000000000000000000000000000006869 162.0
HKD2_k127_6659720_17 Transposase domain (DUF772) K07481 - - 0.00000000000000000000000000008768 118.0
HKD2_k127_6659720_18 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000007609 113.0
HKD2_k127_6659720_19 KEOPS complex Cgi121-like subunit K09119 - - 0.000000000000000000002036 100.0
HKD2_k127_6659720_2 ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA K06932 - 6.3.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008791 429.0
HKD2_k127_6659720_20 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.00000000000000001697 82.0
HKD2_k127_6659720_21 PFAM Phosphoribulokinase uridine kinase K00855 - 2.7.1.19 0.000000000000000034 82.0
HKD2_k127_6659720_22 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.0000000000000001942 83.0
HKD2_k127_6659720_23 PFAM Phosphoribulokinase uridine kinase K00855 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.19 0.0000000000009922 73.0
HKD2_k127_6659720_24 Transposase domain (DUF772) K07481 - - 0.0000000000376 64.0
HKD2_k127_6659720_25 - - - - 0.000000001872 62.0
HKD2_k127_6659720_26 - - - - 0.000000007248 62.0
HKD2_k127_6659720_27 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.000001029 52.0
HKD2_k127_6659720_3 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 349.0
HKD2_k127_6659720_4 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 320.0
HKD2_k127_6659720_5 PFAM peptidase M24 K01262 - 3.4.11.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 319.0
HKD2_k127_6659720_6 archaeal coiled-coil protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003018 307.0
HKD2_k127_6659720_7 S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis K20215 - 2.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003758 298.0
HKD2_k127_6659720_8 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 - 2.5.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 292.0
HKD2_k127_6659720_9 HTH-type transcriptional regulatory protein K07728 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004563 286.0
HKD2_k127_6690406_0 Ammonium Transporter K03320 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006636 559.0
HKD2_k127_6690406_1 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.000000000000000000000000000000000000000000000000000000000000000003297 231.0
HKD2_k127_6690406_2 Belongs to the P(II) protein family K04751 - - 0.000000000000000000000000000000000000000004625 156.0
HKD2_k127_6690406_3 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000006926 160.0
HKD2_k127_6690406_4 TIGRFAM arsenite-activated ATPase ArsA K01551 - 3.6.3.16 0.00000000000000000000000002095 115.0
HKD2_k127_6690406_5 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.0001746 44.0
HKD2_k127_6721292_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000197 560.0
HKD2_k127_6721292_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000025 370.0
HKD2_k127_6721292_2 GTP-binding protein K06883 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 310.0
HKD2_k127_6721292_3 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.0000000000000000000000000000000000008373 142.0
HKD2_k127_6721292_4 Uncharacterized protein conserved in archaea (DUF2111) - - - 0.0000000000000000000000000002331 118.0
HKD2_k127_6721292_5 Zn-ribbon containing protein K07163 - - 0.00000000000000000001009 98.0
HKD2_k127_6721292_6 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 - - - 0.000000000000000703 83.0
HKD2_k127_6721292_7 Mo-molybdopterin cofactor metabolic process K03753 - - 0.000185 46.0
HKD2_k127_6735455_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007744 563.0
HKD2_k127_6735455_1 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 385.0
HKD2_k127_6735455_2 Domain of unknown function (DUF1743) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 318.0
HKD2_k127_6735455_3 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 319.0
HKD2_k127_6735455_4 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000002713 117.0
HKD2_k127_6737047_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003263 250.0
HKD2_k127_6737047_1 DNA photolyase activity - - - 0.0000000000000000000000000000000001344 142.0
HKD2_k127_6739582_0 Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT K00320 - 1.5.98.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000002109 263.0
HKD2_k127_6739582_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000009427 247.0
HKD2_k127_6739582_2 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000003389 207.0
HKD2_k127_6739582_3 tRNAHis guanylyltransferase - - - 0.00000000000000000000000000000000000000000000000000000001423 205.0
HKD2_k127_6739582_4 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000002313 137.0
HKD2_k127_6739582_5 PFAM PRC-barrel domain - - - 0.00000000000000000004769 92.0
HKD2_k127_6739582_6 F420H2 dehydrogenase subunit FpoO K22170 - 1.5.98.3 0.0000197 50.0
HKD2_k127_6740221_0 PFAM RDD domain containing protein - - - 0.0000000000000000000000000000002698 127.0
HKD2_k127_6740221_1 - - - - 0.000000000000000000000000576 109.0
HKD2_k127_6748630_0 PFAM Glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 332.0
HKD2_k127_6748630_1 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009986 320.0
HKD2_k127_6748630_2 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000000000000000001075 241.0
HKD2_k127_6748630_3 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000000001865 183.0
HKD2_k127_6748630_4 Subtilase family K17734 - - 0.0009216 50.0
HKD2_k127_6748681_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 490.0
HKD2_k127_6748681_1 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000002724 230.0
HKD2_k127_6748681_2 MafB19-like deaminase K01493 - 3.5.4.12 0.00000000000000000000000000000000000000000000000000000000000003491 217.0
HKD2_k127_6748681_3 PFAM NADPH-dependent FMN reductase - - - 0.00002976 46.0
HKD2_k127_6749315_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009267 365.0
HKD2_k127_6749315_1 COG0842 ABC-type multidrug transport system, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001215 273.0
HKD2_k127_6749315_2 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000001727 228.0
HKD2_k127_6783927_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.0 1077.0
HKD2_k127_6783927_1 PFAM DNA alkylation repair enzyme - - - 0.00000000001744 64.0
HKD2_k127_6798655_0 CoA binding domain - - - 3.269e-233 737.0
HKD2_k127_6798655_1 PFAM dihydropteroate synthase, DHPS - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 415.0
HKD2_k127_6798655_2 PAC2 family K06869 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001533 248.0
HKD2_k127_6798655_3 Protein of unknown function (DUF473) K09135 - - 0.0000000000000000000000001995 111.0
HKD2_k127_6798655_4 - - - - 0.0000000258 64.0
HKD2_k127_680580_0 PFAM GCN5-related N-acetyltransferase K03824 - - 0.00000000000000000000000000000000000000000000000000000000000005372 215.0
HKD2_k127_680580_1 Acid phosphatase homologues K19302 - 3.6.1.27 0.00000000000000000000002187 108.0
HKD2_k127_680580_2 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.000000000000000000008142 98.0
HKD2_k127_6840490_0 LOR SDH bifunctional protein conserved domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 507.0
HKD2_k127_6840490_1 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 419.0
HKD2_k127_6840490_2 RNA ligase K07468 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003961 356.0
HKD2_k127_6840490_3 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009179 280.0
HKD2_k127_6840490_4 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003788 245.0
HKD2_k127_6840490_5 TIGRFAM TIGR00304 family protein - - - 0.0000008539 55.0
HKD2_k127_6843351_0 acid binding OB-fold tRNA helicase-type K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000424 521.0
HKD2_k127_6857906_0 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 313.0
HKD2_k127_6857906_1 PFAM flavin reductase domain protein, FMN-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 296.0
HKD2_k127_6857906_2 Domain of Unknown Function (DUF1259) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004022 277.0
HKD2_k127_6857906_3 - - - - 0.00000005125 57.0
HKD2_k127_6857906_4 Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO K18931 - 2.4.2.57 0.00000098 53.0
HKD2_k127_6857906_5 - - - - 0.000002366 53.0
HKD2_k127_687372_0 TIGRFAM 26S proteasome subunit P45 family K03420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000052 495.0
HKD2_k127_687372_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000114 421.0
HKD2_k127_687372_2 PFAM Linocin_M18 bacteriocin protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008244 323.0
HKD2_k127_687372_3 PINc domain ribonuclease K09006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 292.0
HKD2_k127_687372_4 Domain of unknown function DUF128 K21640 - - 0.0000000000000000000000000000000000000000000000000000000000000000002693 236.0
HKD2_k127_687372_5 Necessary for normal cell division and for the maintenance of normal septation - - - 0.000000000000000000000000000000000000000000000000000000004331 204.0
HKD2_k127_687372_6 Rubrerythrin - - - 0.000000000000000000000000000000000000000007688 156.0
HKD2_k127_687372_7 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000006671 142.0
HKD2_k127_687372_8 Putative zinc- or iron-chelating domain K06940 - - 0.00000001038 64.0
HKD2_k127_6876065_0 Domain of unknown function (DUF4352) - - - 0.0000000000004622 75.0
HKD2_k127_6876065_1 metal-dependent phosphoesterases (PHP family) - - - 0.000004217 51.0
HKD2_k127_6876950_0 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 329.0
HKD2_k127_6876950_1 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000004974 162.0
HKD2_k127_6876950_2 Thioredoxin K03671 - - 0.00000000000000000002267 96.0
HKD2_k127_6876950_3 - - - - 0.000002366 53.0
HKD2_k127_6903761_0 PFAM AAA ATPase central domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 502.0
HKD2_k127_6903761_1 PFAM beta-lactamase domain protein K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000116 313.0
HKD2_k127_6903761_2 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000002436 134.0
HKD2_k127_6903761_3 Transposase and inactivated derivatives K07494 - - 0.000000006279 59.0
HKD2_k127_6952441_0 Transposase domain (DUF772) K07481 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001441 359.0
HKD2_k127_6952441_1 Chagasin family peptidase inhibitor I42 K14475 - - 0.0002845 49.0
HKD2_k127_6954202_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1103.0
HKD2_k127_6954202_1 DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks K03726 - - 4.889e-213 682.0
HKD2_k127_6954202_2 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006708 471.0
HKD2_k127_6954202_3 Belongs to the UPF0200 family - - - 0.0000000000000000000000000000000000002378 147.0
HKD2_k127_6954202_4 TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein K04069 - 1.97.1.4 0.000000000000000000000000000000000006038 147.0
HKD2_k127_6954202_5 - - - - 0.00000000000000000000000000000000003617 140.0
HKD2_k127_6954202_6 Transglutaminase-like superfamily - - - 0.00000000008414 74.0
HKD2_k127_6954202_7 - - - - 0.00000004946 55.0
HKD2_k127_6954202_8 Uncharacterized protein conserved in archaea (DUF2098) - - - 0.000003452 52.0
HKD2_k127_6985034_0 PFAM ferredoxin-dependent glutamate synthase - - - 7.98e-231 718.0
HKD2_k127_6985034_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 357.0
HKD2_k127_6985034_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000005983 213.0
HKD2_k127_6985034_3 NADPH-dependent F420 reductase K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000009351 164.0
HKD2_k127_6985034_4 Transcriptional regulator, TrmB - - - 0.000000000000000000000000000000000002062 141.0
HKD2_k127_6992443_0 tigrfam pas - - - 0.0000000000000000000000000000000000000000000000000007561 199.0
HKD2_k127_701492_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 - 5.99.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 544.0
HKD2_k127_701492_1 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003793 478.0
HKD2_k127_701492_10 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K20881 - 3.1.3.5 0.000000000000000000000000000000000000000000000002421 180.0
HKD2_k127_701492_11 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000002872 146.0
HKD2_k127_701492_12 Belongs to the eukaryotic ribosomal protein eL21 family K02889 - - 0.0000000000000000000000000000004349 124.0
HKD2_k127_701492_13 PFAM RNA polymerase Rpb4 K03051 - 2.7.7.6 0.0000000000000000000000000002969 117.0
HKD2_k127_701492_14 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 0.00000000000000006364 84.0
HKD2_k127_701492_2 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002504 421.0
HKD2_k127_701492_3 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000000000000000000000000000000000000000000001157 235.0
HKD2_k127_701492_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03047 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000007069 232.0
HKD2_k127_701492_5 Located on the platform of the 30S subunit K02948 - - 0.00000000000000000000000000000000000000000000000000000000000001129 216.0
HKD2_k127_701492_6 Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs K16317 - 2.1.1.257 0.0000000000000000000000000000000000000000000000000000000000005286 217.0
HKD2_k127_701492_7 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.000000000000000000000000000000000000000000000000000000000001249 216.0
HKD2_k127_701492_8 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000007421 195.0
HKD2_k127_701492_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000004554 190.0
HKD2_k127_7016196_0 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000006919 241.0
HKD2_k127_7016196_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.00000000000000000000008126 100.0
HKD2_k127_7016196_2 PFAM TPR repeat-containing protein - - - 0.00005286 53.0
HKD2_k127_7019405_0 TIGRFAM Acetate-CoA ligase K01895 - 6.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000157 589.0
HKD2_k127_7019405_1 SMART Elongator protein 3 MiaB NifB K15865 - 2.8.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 324.0
HKD2_k127_7019405_2 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000000000000000000000009131 246.0
HKD2_k127_70340_0 Radical SAM superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004643 368.0
HKD2_k127_70340_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005393 302.0
HKD2_k127_70340_2 membrane - - - 0.000007002 59.0
HKD2_k127_70340_3 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00001405 48.0
HKD2_k127_7049371_0 PFAM Orn Lys Arg decarboxylase major region K01582,K01584 - 4.1.1.18,4.1.1.19 1.865e-316 985.0
HKD2_k127_7049371_1 PFAM amino acid permease-associated region K20265 - - 1.089e-195 620.0
HKD2_k127_7049371_2 META domain - - - 0.000000000000005033 83.0
HKD2_k127_7055283_0 PFAM von Willebrand factor type A - - - 0.000000000000000000000000000000000000006378 168.0
HKD2_k127_7055283_1 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.00000000000000003059 83.0
HKD2_k127_7055283_2 S-layer homology domain - - - 0.000000000000005677 89.0
HKD2_k127_7055699_0 transposase IS116 IS110 IS902 family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008008 362.0
HKD2_k127_7055699_1 Transposase DDE domain - - - 0.00000000000004255 78.0
HKD2_k127_7067876_0 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 503.0
HKD2_k127_7067876_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000002054 243.0
HKD2_k127_7067876_2 Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000006499 148.0
HKD2_k127_7067876_3 Thiamine-binding protein - - - 0.0000000000000001971 82.0
HKD2_k127_7114216_0 PFAM peptidase U32 K08303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002894 488.0
HKD2_k127_7114216_1 Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily K00560 - 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 288.0
HKD2_k127_7114216_2 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K03394 - 2.1.1.130,2.1.1.151 0.0000000000000000000000000000000000000000000000000000000001394 209.0
HKD2_k127_7114216_3 PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase K05936 - 2.1.1.133,2.1.1.271 0.0000000000000000000000000000000000000000000000000000002588 198.0
HKD2_k127_7114216_4 - - - - 0.00000000000000000000000000000000001254 142.0
HKD2_k127_7114216_5 Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 K02191 - 2.1.1.196 0.00000000000000000000000000001072 124.0
HKD2_k127_7195959_0 Ion channel K10716 - - 0.00000000000000000000000000000000000000000000000000000000005756 213.0
HKD2_k127_7195959_1 radical SAM domain protein - - - 0.00000000000000000000000000000000000001491 154.0
HKD2_k127_7235096_0 Carboxypeptidase regulatory-like domain K01365,K02030,K14475 - 3.4.22.15 0.0000001654 61.0
HKD2_k127_7235096_1 Protein of unknown function (DUF1328) - - - 0.0002544 44.0
HKD2_k127_7252372_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 7.548e-300 935.0
HKD2_k127_7252372_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 304.0
HKD2_k127_7252372_2 Heterodisulfide reductase, subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000002153 213.0
HKD2_k127_7252372_3 4Fe-4S dicluster domain K03389,K03390,K16887,K18930 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000004868 126.0
HKD2_k127_7252372_4 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00205 - - 0.000000000000000000000000000115 118.0
HKD2_k127_7271126_0 Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex K03264 - - 0.000000000000000000000000000000000000000000000000000000000000002077 225.0
HKD2_k127_7271126_1 Belongs to the eukaryotic ribosomal protein eL31 family K02910 - - 0.0000000000000000000000005302 106.0
HKD2_k127_7271126_2 subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain K07585 - - 0.0000000000000000000004817 99.0
HKD2_k127_7271126_3 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000007915 98.0
HKD2_k127_7271126_4 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.00000000000000000002005 96.0
HKD2_k127_7271126_5 Belongs to the eukaryotic ribosomal protein eL39 family K02924 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000007439 73.0
HKD2_k127_7271126_6 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A K02944 - - 0.00001992 49.0
HKD2_k127_7271426_0 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000006622 212.0
HKD2_k127_7271426_1 cell wall organization - - - 0.000000000000000000000000000001569 139.0
HKD2_k127_7336637_0 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 1.006e-278 860.0
HKD2_k127_7336637_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 577.0
HKD2_k127_7336637_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000006193 117.0
HKD2_k127_7336637_3 Molydopterin dinucleotide binding domain K00203 - 1.2.7.12 0.0000000000000005566 83.0
HKD2_k127_7336810_0 PHP C-terminal domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000417 412.0
HKD2_k127_7336810_1 AIR carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007653 246.0
HKD2_k127_7336810_2 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.000000000000000000227 89.0
HKD2_k127_7347669_0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000001078 188.0
HKD2_k127_7399429_0 PFAM ADP-ribosylation Crystallin J1 - - - 0.0000000000000000000000000000000000000000000000000000000000000002644 232.0
HKD2_k127_7399429_1 Methyltransferase type 11 - - - 0.00000000000000000000000000000000000000000000000000008839 193.0
HKD2_k127_7399429_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000000000000000000000001573 138.0
HKD2_k127_7399429_3 - - - - 0.00000000000001169 80.0
HKD2_k127_7472000_0 tigrfam pas - - - 0.000000000000000000000000000000000000000000005813 184.0
HKD2_k127_7472000_1 PFAM Stage II sporulation E family protein K07315 - 3.1.3.3 0.000000000000000000000000000000001033 149.0
HKD2_k127_7476721_0 Domain of unknown function DUF123 - - - 0.0000000000000000000000000000000007108 136.0
HKD2_k127_7476721_1 Belongs to the 'phage' integrase family K04763 - - 0.0000000000000000000001273 109.0
HKD2_k127_7517825_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 544.0
HKD2_k127_7517825_1 Catalyzes the formation of S-adenosylmethionine from methionine and ATP K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 299.0
HKD2_k127_7517825_2 - - - - 0.00000000000000000000000004475 110.0
HKD2_k127_7563996_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001759 469.0
HKD2_k127_7563996_1 ABC transporter, substrate-binding protein, aliphatic K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 398.0
HKD2_k127_7563996_10 PFAM PQ loop repeat K15383 - - 0.0000000000005771 73.0
HKD2_k127_7563996_2 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 - 2.4.2.18,4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 368.0
HKD2_k127_7563996_3 PFAM elongation factor Tu domain 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006605 366.0
HKD2_k127_7563996_4 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 299.0
HKD2_k127_7563996_5 TIGRFAM glutamine amidotransferase of anthranilate synthase K01658 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000003006 214.0
HKD2_k127_7563996_6 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000000000000000000000000000000000000000000000004496 206.0
HKD2_k127_7563996_7 Protein of unknown function (DUF460) K09150 - - 0.00000000000000000000000000000000000000000000000000000001886 210.0
HKD2_k127_7563996_8 PFAM Indole-3-glycerol phosphate synthase K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000378 200.0
HKD2_k127_7563996_9 Belongs to the TrpF family K01696,K01817 - 4.2.1.20,5.3.1.24 0.00000000000000000000000000000000000006442 150.0
HKD2_k127_7565889_0 shikimate kinase activity K00891 - 2.7.1.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003978 311.0
HKD2_k127_7565889_1 PFAM peptidase M42 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002454 252.0
HKD2_k127_7565889_2 Lycopene cyclase protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009247 257.0
HKD2_k127_7565889_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000001398 168.0
HKD2_k127_7565889_4 Universal stress protein - - - 0.00000000000000000002544 96.0
HKD2_k127_7565889_5 chorismate mutase K04093 - 5.4.99.5 0.00000000000000001587 86.0
HKD2_k127_7590949_0 - - - - 0.0000000000000000001495 93.0
HKD2_k127_7590949_1 Protein of unknown function DUF72 - - - 0.0000000000000002952 81.0
HKD2_k127_7667887_0 Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids K16306 - 2.2.1.10,4.1.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 409.0
HKD2_k127_7667887_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001673 379.0
HKD2_k127_7667887_2 Catalyzes the conversion of dihydroorotate to orotate K17828 - 1.3.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 339.0
HKD2_k127_7667887_3 Fumarylacetoacetate (FAA) hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 300.0
HKD2_k127_7667887_4 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002701 267.0
HKD2_k127_7674411_0 Truncated hemoglobins K06886 - - 0.0000000000000000000000000000000000000000000000000000000000004561 214.0
HKD2_k127_7674411_1 Hemerythrin HHE cation binding K07322 - - 0.000000000000000000000000000000000000000000000000001415 188.0
HKD2_k127_7674411_2 LysM domain - - - 0.0000000000000000000000000000000000000000000000142 178.0
HKD2_k127_7674411_3 cellular manganese ion homeostasis - - - 0.0000000000000000000000000000000000000000001313 163.0
HKD2_k127_7674411_4 Tetratricopeptide repeat K12600 - - 0.00000000000000000000000000000000000003105 151.0
HKD2_k127_7674411_5 Cytochrome C biogenesis protein transmembrane region - - - 0.0000000000000000000000000000002369 130.0
HKD2_k127_7674411_6 SnoaL-like polyketide cyclase - - - 0.0000000000000000000000000002769 119.0
HKD2_k127_7674411_7 DNA polymerase activity K02319 - 2.7.7.7 0.000000000000001526 83.0
HKD2_k127_7674411_8 DNA-binding transcription factor activity - - - 0.0000000001624 67.0
HKD2_k127_7703018_0 Sulfatase K01130 - 3.1.6.1 3.395e-198 634.0
HKD2_k127_7703018_1 Iron-sulfur cluster-binding domain K06871 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 565.0
HKD2_k127_7703018_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008856 381.0
HKD2_k127_7703018_3 - - - - 0.000000000000001567 79.0
HKD2_k127_7739873_0 TGS domain protein K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002709 496.0
HKD2_k127_7739873_1 Hydantoinase/oxoprolinase K07072 - 2.5.1.131 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 297.0
HKD2_k127_7739873_2 PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit K00441,K22174 - 1.1.98.4,1.12.98.1 0.00000000000000000000000000000000000000000000000000000000000002717 228.0
HKD2_k127_7753987_0 Hydrolyase tartrate alpha subunit fumarate domain protein Fe-S type K01676,K01677 - 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000009562 225.0
HKD2_k127_7753987_1 O-acyltransferase activity - - - 0.0001254 53.0
HKD2_k127_7756693_0 An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation K12574 - - 1.032e-200 633.0
HKD2_k127_7756693_1 Iron-sulfur cluster-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 381.0
HKD2_k127_7756693_2 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002331 366.0
HKD2_k127_7756693_3 CoA-binding domain protein K06929 - - 0.0000000000000000000000000000000000000000000000000001958 188.0
HKD2_k127_7756693_4 Polyprenyl synthetase K02523 GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765 2.5.1.90 0.000000000000000000000000000000000000000000000000000215 196.0
HKD2_k127_7756693_5 PFAM Cache, type 2 domain protein - - - 0.000000000000000000000000000000001193 134.0
HKD2_k127_7756693_6 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.0000000000000000000002755 99.0
HKD2_k127_7756693_7 - - - - 0.0000000000006403 72.0
HKD2_k127_7756693_8 - - - - 0.000000007847 58.0
HKD2_k127_7783043_0 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002257 344.0
HKD2_k127_7783043_1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 310.0
HKD2_k127_7783043_2 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000000000000000000000000000000001415 199.0
HKD2_k127_7864233_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 3.84e-217 683.0
HKD2_k127_7864233_1 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 302.0
HKD2_k127_7864233_2 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000000000000000000000002568 258.0
HKD2_k127_7864233_3 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 - 2.7.7.2 0.000000000000000000000000000000000000000000000000006016 184.0
HKD2_k127_7864233_4 Prokaryotic homologs of the JAB domain - - - 0.00000000000000000000000000000000000000000026 162.0
HKD2_k127_7864233_5 pyridoxamine 5'-phosphate oxidase-related FMN-binding K07005 - - 0.00000000000001661 79.0
HKD2_k127_7864233_6 Phosphopantetheine adenylyltransferase K02201 - 2.7.7.3 0.000001775 51.0
HKD2_k127_790112_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009804 594.0
HKD2_k127_790112_1 Belongs to the Glu Leu Phe Val dehydrogenases family K00260,K00261 - 1.4.1.2,1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005665 522.0
HKD2_k127_790112_2 PFAM ferredoxin-dependent glutamate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001711 279.0
HKD2_k127_7938971_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 2.724e-230 731.0
HKD2_k127_7938971_1 Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005794 424.0
HKD2_k127_7938971_2 phosphoribosyltransferase K07100 - - 0.000000000000000000000000000000000000000000000000000000000000802 217.0
HKD2_k127_7956544_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001511 290.0
HKD2_k127_799432_0 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 2.212e-268 844.0
HKD2_k127_799432_1 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 488.0
HKD2_k127_799432_2 PFAM Sugar isomerase (SIS) K08094 - 5.3.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000112 268.0
HKD2_k127_799432_3 S-layer protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000006818 260.0
HKD2_k127_799432_4 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.00000000000000000000000000000000000000000005194 166.0
HKD2_k127_799432_5 PFAM Imidazoleglycerol-phosphate dehydratase K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.00000000000000000000000000164 118.0
HKD2_k127_8000086_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001526 256.0
HKD2_k127_801876_0 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00030 - 1.1.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004918 576.0
HKD2_k127_801876_1 Protein of unknown function (DUF460) K09150 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 343.0
HKD2_k127_801876_2 DHH family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005147 274.0
HKD2_k127_801876_3 PFAM transferase hexapeptide repeat containing protein - - - 0.0000000000000000000000000000000000000000000000000000000000000003895 236.0
HKD2_k127_801876_4 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 0.0000000000000000000000000000000001144 135.0
HKD2_k127_801876_5 uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000004149 59.0
HKD2_k127_8036212_0 Amino acid permease K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000106 239.0
HKD2_k127_8036212_1 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000003259 208.0
HKD2_k127_8036212_2 Permease - - - 0.00000000000000000000000000000000000000001242 168.0
HKD2_k127_8036212_3 RibD C-terminal domain K14654 - 1.1.1.302 0.00000000000006352 76.0
HKD2_k127_8036212_4 amino acid - - - 0.00000000000006796 80.0
HKD2_k127_8036212_5 Protein of unknown function (DUF4064) - - - 0.0000000004152 66.0
HKD2_k127_8036212_6 RibD C-terminal domain K14654 - 1.1.1.302 0.0001071 44.0
HKD2_k127_8067868_0 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009532 582.0
HKD2_k127_8067868_1 Bacterial PH domain - - - 0.0000000000000000000000000000001311 129.0
HKD2_k127_8092035_0 COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008388 265.0
HKD2_k127_8113400_0 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000507 511.0
HKD2_k127_8113400_1 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.0000000000000000000000000000000000000000000000004171 179.0
HKD2_k127_8113400_2 Sodium:solute symporter family K03307 - - 0.000000000000000000000000000000000000000000000007526 189.0
HKD2_k127_8113400_3 Lrp/AsnC ligand binding domain - - - 0.0000000007439 66.0
HKD2_k127_8113400_4 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00581 - 2.1.1.86 0.000000006051 59.0
HKD2_k127_812651_0 DEAD/H associated K03724 - - 0.0 1084.0
HKD2_k127_8133696_0 PFAM alpha amylase catalytic region - - - 3.355e-266 832.0
HKD2_k127_8133696_1 PFAM binding-protein-dependent transport systems inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000496 332.0
HKD2_k127_8133696_2 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000787 271.0
HKD2_k127_8133696_3 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006893 264.0
HKD2_k127_8133696_4 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000007807 192.0
HKD2_k127_8133696_5 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000007587 125.0
HKD2_k127_8133696_6 - - - - 0.000000000000002489 79.0
HKD2_k127_8133696_7 tetratricopeptide repeat - - - 0.000000000000426 77.0
HKD2_k127_8157152_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 4.603e-225 726.0
HKD2_k127_8157152_1 Peptidase C39 family K06992 - - 0.000000000000000000003553 104.0
HKD2_k127_8157152_2 Tryptophan-rich Synechocystis species C-terminal domain - - - 0.0000000000000011 83.0
HKD2_k127_8157152_3 - - - - 0.0000000001271 67.0
HKD2_k127_8157152_4 Chagasin family peptidase inhibitor I42 K14475 - - 0.00000002461 63.0
HKD2_k127_8157152_5 Belongs to the Fur family K03711,K09825 - - 0.000958 45.0
HKD2_k127_8193871_0 PFAM ferredoxin-dependent glutamate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006731 601.0
HKD2_k127_8193871_1 HMGL-like K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005052 545.0
HKD2_k127_8193871_2 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 - 1.7.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001753 363.0
HKD2_k127_8193871_3 PFAM helix-turn-helix HxlR type - - - 0.000000000000000000000000000000000000000000001727 171.0
HKD2_k127_8193871_4 Formylmethanofuran dehydrogenase subunit D K00203 - 1.2.7.12 0.00000000000000000000000001242 113.0
HKD2_k127_8193871_5 Peptidase family M48 K03799 - - 0.0000000000000000000003797 97.0
HKD2_k127_8208778_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003024 270.0
HKD2_k127_8208778_1 Transposase domain (DUF772) K07481 - - 0.000000000000000002126 88.0
HKD2_k127_8208778_2 Belongs to the UPF0146 family K09713 - - 0.00002283 49.0
HKD2_k127_8211102_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 - 5.99.1.3 3.486e-216 682.0
HKD2_k127_8211102_1 PFAM nucleic acid binding, OB-fold, tRNA helicase-type K07466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 387.0
HKD2_k127_8211102_2 protein conserved in archaea K09746 - - 0.000000000000000000000000000000000000000000000000000000000000004729 226.0
HKD2_k127_8211102_3 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000003595 103.0
HKD2_k127_8284601_0 PFAM ferredoxin-dependent glutamate synthase - - - 2.652e-297 918.0
HKD2_k127_8284601_1 HMGL-like K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007685 576.0
HKD2_k127_8297699_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K09482 - 6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 494.0
HKD2_k127_8297699_1 Belongs to the AAA ATPase family K07392 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 411.0
HKD2_k127_8297699_10 Protein of unknown function (DUF1232) - - - 0.000000000000000000006185 97.0
HKD2_k127_8297699_11 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03540 - 3.1.26.5 0.000000000000001447 81.0
HKD2_k127_8297699_12 - - - - 0.00000000000436 72.0
HKD2_k127_8297699_2 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001377 275.0
HKD2_k127_8297699_3 Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000006817 268.0
HKD2_k127_8297699_4 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.000000000000000000000000000000000000000000000000000000000000000001896 231.0
HKD2_k127_8297699_5 regulator of amino acid metabolism, contains ACT domain K07103 - - 0.000000000000000000000000000000000000000000000000000000000085 208.0
HKD2_k127_8297699_6 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 0.000000000000000000000000000000000000000000000002644 178.0
HKD2_k127_8297699_7 COG3547 Transposase and inactivated derivatives - - - 0.000000000000000000000000000000000000000006282 163.0
HKD2_k127_8297699_8 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor K14941 - 2.7.7.68 0.000000000000000000000000000000000000004749 154.0
HKD2_k127_8297699_9 Protein of unknown function DUF45 K07043 - - 0.00000000000000000000000000001314 123.0
HKD2_k127_8332478_0 PFAM sodium calcium exchanger membrane region K07300 - - 0.0000000000000000000000000000000000000000000004217 171.0
HKD2_k127_8332478_1 Sodium/calcium exchanger protein K07300 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015085,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015368,GO:0015369,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051139,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - 0.000000000000000000000000000000000000000005219 160.0
HKD2_k127_8332478_2 Nitroreductase family - - - 0.000000000000000000000000000000000000054 144.0
HKD2_k127_8332478_3 Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000007466 145.0
HKD2_k127_8381501_0 PFAM Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 344.0
HKD2_k127_8381501_1 Large-conductance mechanosensitive channel, MscL K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.000000000000000000000000000000000000000000000000001186 186.0
HKD2_k127_8381501_2 Peptidase C39, bacteriocin processing - - - 0.000000000002087 77.0
HKD2_k127_8539159_0 Respiratory-chain NADH dehydrogenase domain 51 kDa subunit K00124,K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 597.0
HKD2_k127_8539159_1 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000005219 190.0
HKD2_k127_8539159_2 Divergent 4Fe-4S mono-cluster - - - 0.00000000000000000000000000000000000000005032 156.0
HKD2_k127_8539159_3 PFAM coenzyme F420 hydrogenase dehydrogenase beta subunit domain protein K00441 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016725,GO:0052592,GO:0055114 1.12.98.1 0.00000000000000000000000000000005251 141.0
HKD2_k127_8563196_0 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 554.0
HKD2_k127_8563196_1 domain, Protein K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000009774 191.0
HKD2_k127_8563196_2 Alpha amylase, catalytic domain - - - 0.00000000000000000000000001185 111.0
HKD2_k127_8586331_0 Clp protease K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003124 411.0
HKD2_k127_8586331_1 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 323.0
HKD2_k127_8655620_0 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 307.0
HKD2_k127_8655620_1 PFAM alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.00000000000000000000000000000000000000000000000000003039 190.0
HKD2_k127_8655620_2 PFAM alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.0000000000000000000000000000007996 124.0
HKD2_k127_8676827_0 Chitobiase/beta-hexosaminidase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 478.0
HKD2_k127_8676827_1 PFAM peptidase C14, caspase catalytic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 361.0
HKD2_k127_8731130_0 SMART DNA-directed DNA polymerase B K02319 - 2.7.7.7 5.813e-248 787.0
HKD2_k127_8731130_1 Reverse transcriptase-like K03469 - 3.1.26.4 0.000000008711 59.0
HKD2_k127_8770135_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1354.0
HKD2_k127_8770135_1 PFAM Chaperonin Cpn60 TCP-1 K22447 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 596.0
HKD2_k127_8770135_10 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000001099 107.0
HKD2_k127_8770135_11 SMART Tetratricopeptide repeat - - - 0.000000000000000004754 88.0
HKD2_k127_8770135_2 Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA K04801 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 434.0
HKD2_k127_8770135_3 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000791 244.0
HKD2_k127_8770135_4 PFAM cyclase family protein K07130 - 3.5.1.9 0.00000000000000000000000000000000000000000000002547 178.0
HKD2_k127_8770135_5 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000002082 159.0
HKD2_k127_8770135_6 PFAM methyltransferase small K02493 - 2.1.1.297 0.00000000000000000000000000000000000000009651 158.0
HKD2_k127_8770135_7 TPR Domain containing protein - - - 0.000000000000000000000000000000000009531 142.0
HKD2_k127_8770135_8 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000003722 130.0
HKD2_k127_8770135_9 PFAM TPR repeat-containing protein - - - 0.00000000000000000000000000002512 125.0
HKD2_k127_8782627_0 TIGRFAM TraB family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 398.0
HKD2_k127_8782627_1 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 336.0
HKD2_k127_8782627_2 Serine protease with a broad substrate specificity K13276,K17734 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007316 274.0
HKD2_k127_8782627_3 PFAM Class II Aldolase K01628 - 4.1.2.17 0.00000000000000000000000000000000000000001514 159.0
HKD2_k127_8862452_0 Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin K13812 - 4.1.2.43,4.2.1.147 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 532.0
HKD2_k127_8862452_1 Domain of unknown function (DUF373) K08975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 342.0
HKD2_k127_8862452_2 PFAM glutamate synthase alpha subunit K00202 - 1.2.7.12 0.0000000000000000000000000000000000006336 143.0
HKD2_k127_8862452_3 PFAM periplasmic copper-binding - - - 0.0000000000000000000000000000000005678 148.0
HKD2_k127_8862452_4 Cytochrome C biogenesis protein transmembrane region - - - 0.00000000000003508 81.0
HKD2_k127_890213_0 Glyoxalase-like domain K06996 - - 0.000000000000000000000000000000000001129 143.0
HKD2_k127_890213_1 transcriptional regulator - - - 0.0000000001891 63.0
HKD2_k127_890213_2 PFAM Telomeric repeat-binding factor 2 - - - 0.00004878 52.0
HKD2_k127_8915378_0 Methanogenesis marker 13 metalloprotein K21611 - 6.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002168 463.0
HKD2_k127_8915378_1 PFAM Mur ligase, middle domain protein K21612 - 6.4.1.9 0.000000000000000000000000000000000000000000000000000000000000000007005 240.0
HKD2_k127_8915378_2 integrase family K04763 - - 0.000000000000000000000000000000000007869 141.0
HKD2_k127_8915378_3 Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin K22011 - 4.99.1.11,4.99.1.3 0.000000000000000000000000000000304 126.0
HKD2_k127_8915378_4 transposase activity - - - 0.000000000000000000000004919 118.0
HKD2_k127_8915378_5 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K07342 - - 0.0000000003595 63.0
HKD2_k127_8915378_7 integrase family - - - 0.000002397 56.0
HKD2_k127_8937173_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001867 493.0
HKD2_k127_8937173_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000008475 235.0
HKD2_k127_8937173_2 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000886 220.0
HKD2_k127_8937173_3 transcription termination protein NusA K02600 - - 0.000000000000000000000000000000000000000000000000000005289 192.0
HKD2_k127_8937173_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 0.00000000000000000000000000000000000000015 151.0
HKD2_k127_8937173_5 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000009344 143.0
HKD2_k127_8937173_6 Belongs to the eukaryotic ribosomal protein eL30 family K02908 - - 0.000000000000000000000000001806 114.0
HKD2_k127_8944327_0 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000006853 177.0
HKD2_k127_8944327_1 PFAM TPR repeat-containing protein - - - 0.00000000000000000000000003292 124.0
HKD2_k127_8969923_0 CobW/HypB/UreG, nucleotide-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003054 558.0
HKD2_k127_8969923_1 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.0000000009727 62.0
HKD2_k127_8969923_2 N-6 DNA Methylase - - - 0.000002897 49.0
HKD2_k127_8971834_0 zinc metalloprotease whose natural substrate is K06974 GO:0003674,GO:0003824,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0071704,GO:0140096,GO:1901564 - 0.00000000000000000000000000000000000832 138.0
HKD2_k127_8971834_1 - - - - 0.000000003482 64.0
HKD2_k127_8973711_0 Formylmethanofuran dehydrogenase subunit A K00200 - 1.2.7.12 6.398e-218 689.0
HKD2_k127_8973711_1 PFAM isocitrate isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 578.0
HKD2_k127_8973711_2 Protein of unknown function (DUF1246) K06863 - 6.3.4.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008287 540.0
HKD2_k127_8973711_3 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 505.0
HKD2_k127_8973711_4 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000003089 224.0
HKD2_k127_8973711_5 PFAM glutamate synthase alpha subunit domain protein K00202 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000001948 220.0
HKD2_k127_8973711_6 Formylmethanofuran dehydrogenase subunit D K00203 - 1.2.7.12 0.000000000000000000000702 99.0
HKD2_k127_90836_0 CAAX protease self-immunity K07052 - - 0.0000000000000000123 87.0
HKD2_k127_90836_1 CAAX protease self-immunity K07052 - - 0.00002568 49.0
HKD2_k127_9100224_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 491.0
HKD2_k127_9100224_1 PFAM Glycosyl transferase, group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003238 317.0
HKD2_k127_9121906_0 Protein of unknown function, DUF255 K06888 - - 2.303e-244 772.0
HKD2_k127_9121906_1 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 9.944e-201 640.0
HKD2_k127_9121906_2 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006706 600.0
HKD2_k127_9121906_3 Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase) K05844 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004629 411.0
HKD2_k127_9121906_4 PFAM glutamate--cysteine ligase, GCS2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 395.0
HKD2_k127_9121906_5 Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase K01601 - 4.1.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 376.0
HKD2_k127_9121906_6 RimK-like ATPgrasp N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000001166 219.0
HKD2_k127_9121906_7 Putative zinc- or iron-chelating domain K06940 - - 0.000000000000000000000000000000000000000000942 162.0
HKD2_k127_9121906_8 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000005406 156.0
HKD2_k127_9121906_9 transposase activity K07481 - - 0.0004742 44.0
HKD2_k127_9142637_0 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 412.0
HKD2_k127_9142637_1 Domain of unknown function (DUF2088) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399 372.0
HKD2_k127_9142637_2 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003092 276.0
HKD2_k127_9142637_3 stage II sporulation K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000008453 179.0
HKD2_k127_9142637_4 Thiamine pyrophosphate enzyme, C-terminal K00187 - 1.2.7.7 0.0000000000000000000000000000000000001099 145.0
HKD2_k127_9142637_5 - - - - 0.000000000000003134 85.0
HKD2_k127_9180468_0 Formylmethanofuran dehydrogenase, subunit B K00201 - 1.2.7.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 396.0
HKD2_k127_9180468_1 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002587 369.0
HKD2_k127_9180468_2 Transposase domain (DUF772) K07481 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 329.0
HKD2_k127_9180468_3 Putative Fe-S cluster K11260 - - 0.00000000000000000000000000000000000000000000000001697 183.0
HKD2_k127_9180468_4 Aerotolerance regulator N-terminal - - - 0.0000000000000000000000000000000000002396 149.0
HKD2_k127_9180468_5 Domain of unknown function (DUF4215) - - - 0.0003116 44.0
HKD2_k127_9180468_6 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0040007,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.0005401 43.0
HKD2_k127_927879_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 2.234e-223 697.0
HKD2_k127_927879_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 9.451e-216 678.0
HKD2_k127_927879_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008529 557.0
HKD2_k127_927879_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009719 361.0
HKD2_k127_927879_4 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000007294 181.0
HKD2_k127_927879_5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000007928 117.0
HKD2_k127_9279300_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 - 2.7.7.6 1.381e-306 950.0
HKD2_k127_9279300_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044 - 2.7.7.6 2.19e-301 933.0
HKD2_k127_9279300_2 Belongs to the RNA polymerase beta chain family K03045 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 323.0
HKD2_k127_9281693_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 3.588e-222 703.0
HKD2_k127_9281693_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 2.26e-196 622.0
HKD2_k127_9281693_10 Adenylylsulphate kinase K00860 - 2.7.1.25 0.000000000000000000000000000000000000000000000002306 180.0
HKD2_k127_9281693_11 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000001165 175.0
HKD2_k127_9281693_12 - - - - 0.0000000000000000000000000000000000000001604 156.0
HKD2_k127_9281693_13 Stage II sporulation protein M K06384 - - 0.00000000000000000000000000001201 125.0
HKD2_k127_9281693_14 Non-histone chromosomal protein MC1 - - - 0.0000000000000000000000000002912 115.0
HKD2_k127_9281693_15 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02869 - - 0.00000000000000000000000001897 111.0
HKD2_k127_9281693_16 Mn2 dependent serine threonine protein kinase - - - 0.00000000000000000000000008308 108.0
HKD2_k127_9281693_17 Belongs to the UPF0434 family - - - 0.00000000000000000000001334 100.0
HKD2_k127_9281693_18 ChaB K06197 - - 0.00000000000007407 75.0
HKD2_k127_9281693_19 Transposase and inactivated derivatives - - - 0.00000000001082 68.0
HKD2_k127_9281693_2 PFAM Radical SAM domain protein K06937 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006948 552.0
HKD2_k127_9281693_20 SPTR Transposase, IS4 family protein - - - 0.0000000003464 63.0
HKD2_k127_9281693_21 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00150 - 1.2.1.59 0.000000001516 70.0
HKD2_k127_9281693_22 Transposase and inactivated derivatives K07494 - - 0.000000003855 59.0
HKD2_k127_9281693_3 Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation K02232 - 6.3.5.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000538 550.0
HKD2_k127_9281693_4 sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp K01170 - 4.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 327.0
HKD2_k127_9281693_5 RNA methylase K07446 - 2.1.1.213 0.000000000000000000000000000000000000000000000000000000000000000000000000000006851 271.0
HKD2_k127_9281693_6 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009579 242.0
HKD2_k127_9281693_7 ATP-grasp domain K06914 - 6.3.4.24 0.000000000000000000000000000000000000000000000000000000000000000006091 236.0
HKD2_k127_9281693_8 Transcription elongation factor Spt5 K02601 - - 0.0000000000000000000000000000000000000000000000000000000000000000124 226.0
HKD2_k127_9281693_9 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000003636 226.0
HKD2_k127_9281873_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 1.76e-216 683.0
HKD2_k127_9281873_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002744 391.0
HKD2_k127_9281873_10 Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome K02892 - - 0.000000000000000000008799 93.0
HKD2_k127_9281873_11 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 GO:0000172,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005732,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.000000000000000002917 87.0
HKD2_k127_9281873_12 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.000000000000002566 77.0
HKD2_k127_9281873_2 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002586 355.0
HKD2_k127_9281873_3 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004354 319.0
HKD2_k127_9281873_4 Binds the lower part of the 30S subunit head K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 294.0
HKD2_k127_9281873_5 Putative RNA methyltransferase K09142 - - 0.00000000000000000000000000000000000000000000000000000000000000003965 232.0
HKD2_k127_9281873_6 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000008248 200.0
HKD2_k127_9281873_7 TIR domain - - - 0.0000000000000000000000000000000000000000000000000000008985 198.0
HKD2_k127_9281873_8 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000000000000000000002218 182.0
HKD2_k127_9281873_9 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000004403 159.0
HKD2_k127_9285690_0 Belongs to the eIF-2B alpha beta delta subunits family K18237 - 5.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003719 367.0
HKD2_k127_9285690_1 Flavodoxin domain K03809 - 1.6.5.2 0.0000000000000000000000000000000000000000003803 162.0
HKD2_k127_9289490_0 ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues K01648 GO:0000166,GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003878,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005829,GO:0005886,GO:0006066,GO:0006082,GO:0006084,GO:0006085,GO:0006101,GO:0006107,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006694,GO:0006695,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008144,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009893,GO:0009987,GO:0012505,GO:0015936,GO:0016020,GO:0016053,GO:0016125,GO:0016126,GO:0016192,GO:0016740,GO:0016746,GO:0016999,GO:0017076,GO:0017144,GO:0018130,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030141,GO:0030554,GO:0031323,GO:0031325,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032940,GO:0032991,GO:0033500,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0034774,GO:0035337,GO:0035383,GO:0035384,GO:0035578,GO:0035639,GO:0036094,GO:0036230,GO:0042119,GO:0042582,GO:0042592,GO:0042593,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046165,GO:0046390,GO:0046394,GO:0046483,GO:0046903,GO:0046912,GO:0046949,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0055086,GO:0060205,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0071944,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:0101002,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901568,GO:1901570,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653,GO:1904813 2.3.3.8 6.119e-231 731.0
HKD2_k127_9289490_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002478 529.0
HKD2_k127_9289490_2 ATP citrate lyase citrate-binding K15231 - 2.3.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002651 486.0
HKD2_k127_9289490_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001958 259.0
HKD2_k127_9289490_4 integral membrane protein K07027 - - 0.00000000000000000000000000000000000000000000000006677 191.0
HKD2_k127_9289490_5 SMART phosphoesterase PHP domain protein - - - 0.000000000000000000000000000000000000000000000001152 181.0
HKD2_k127_9289490_6 Family of unknown function (DUF5350) - - - 0.000000000005849 67.0
HKD2_k127_9289490_7 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.0000005619 53.0
HKD2_k127_9293872_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1564.0
HKD2_k127_9293872_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1053.0
HKD2_k127_9293872_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 4.771e-230 721.0
HKD2_k127_9293872_3 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004497 321.0
HKD2_k127_9293872_4 Thioredoxin - - - 0.000000000000000000000000000000000000003251 149.0
HKD2_k127_9293872_5 - - - - 0.00000000000005541 75.0
HKD2_k127_9294261_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 344.0
HKD2_k127_9294261_1 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009174 339.0
HKD2_k127_9294261_2 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 288.0
HKD2_k127_9294261_3 PFAM band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000299 281.0
HKD2_k127_9294261_4 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 0.000000000000000000000000001611 113.0
HKD2_k127_9294261_5 PFAM ribonuclease II K01147 - 3.1.13.1 0.000000000000000000169 91.0
HKD2_k127_9294261_6 PINc domain ribonuclease K09006 - - 0.00000000000003301 74.0
HKD2_k127_9294261_7 Ferric uptake regulator, Fur family K03711,K09825 GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2000374,GO:2001141 - 0.000000000001425 70.0
HKD2_k127_9294261_8 Belongs to the Fur family K09825 - - 0.000000007942 59.0
HKD2_k127_9294261_9 Zn-dependent metallo-hydrolase RNA specificity domain K12574 - - 0.00003852 47.0
HKD2_k127_9308942_0 PFAM Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 427.0
HKD2_k127_9308942_1 Glycosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006772 343.0
HKD2_k127_9308942_2 glycosyltransferase - - - 0.0000000000000000000000000000000000000000000000001934 189.0
HKD2_k127_9308942_3 Methyltransferase type 11 - - - 0.0000000000000000000000000000000000000000000003141 174.0
HKD2_k127_9308942_4 PFAM Molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.00000000001337 65.0
HKD2_k127_9315838_0 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein K00174 - 1.2.7.11,1.2.7.3 4.303e-194 619.0
HKD2_k127_9315838_1 PhoQ Sensor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000019 440.0
HKD2_k127_9315838_2 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009044 291.0
HKD2_k127_9331025_0 - - - - 0.00000000000000000000000000000000000007589 147.0
HKD2_k127_9331025_1 Acetyl xylan esterase (AXE1) K06889 - - 0.0000000000000000000000000000000002203 138.0
HKD2_k127_9331025_2 - - - - 0.000000000000000000000000000000002358 132.0
HKD2_k127_9331025_3 Acetyl xylan esterase (AXE1) K06889 - - 0.0000000000000000000000000005512 117.0
HKD2_k127_9331025_4 - - - - 0.0000000000004171 72.0
HKD2_k127_9331025_5 - - - - 0.0000001332 55.0
HKD2_k127_9331025_6 - - - - 0.0000004049 57.0
HKD2_k127_9331025_7 E1-E2 ATPase K01534 - 3.6.3.3,3.6.3.5 0.00006711 46.0
HKD2_k127_9334262_0 Methanogenesis marker protein 8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002966 328.0
HKD2_k127_9334262_1 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000000000000000000000000000004163 198.0
HKD2_k127_9334262_2 integrase family K04763 - - 0.0000000000000000000000000000000000000000003592 170.0
HKD2_k127_9334262_3 - - - - 0.00000000000000000000000000000000001363 139.0
HKD2_k127_9336716_0 PFAM Cache, type 2 domain protein - - - 0.0000000000000000000000000000000000000000005925 162.0
HKD2_k127_9336716_1 PFAM extracellular solute-binding protein family 3 K02030 - - 0.00000000000000000000000000000000000000003134 157.0
HKD2_k127_9336716_2 COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain - - - 0.0000000000002669 75.0
HKD2_k127_9336716_3 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds. It is involved in the biological process described with carbohydrate metabolic process - GO:0003674,GO:0003824,GO:0004553,GO:0004568,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006030,GO:0006032,GO:0006040,GO:0006807,GO:0008061,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016798,GO:0017144,GO:0042737,GO:0043170,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046348,GO:0071704,GO:0097367,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - 0.0006833 51.0
HKD2_k127_9380010_0 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 293.0
HKD2_k127_9380010_1 Belongs to the phosphoglycerate kinase family K00927 - 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000007033 235.0
HKD2_k127_9431773_0 acyl-phosphate glycerol-3-phosphate acyltransferase activity K08591 - 2.3.1.15 0.000139 52.0
HKD2_k127_9447710_0 - - - - 0.0000000000000000000000000000000000000000000002393 175.0
HKD2_k127_9447710_1 PFAM Phosphatidic acid phosphatase type 2 haloperoxidase K19302 - 3.6.1.27 0.0000000000000000005084 91.0
HKD2_k127_9447710_2 alginic acid biosynthetic process K01795,K20276 - 5.1.3.37 0.0000000000294 76.0
HKD2_k127_9460306_0 PFAM Prephenate dehydrogenase K04517 - 1.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002397 338.0
HKD2_k127_9460306_1 PFAM Glutamine cyclotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001012 271.0
HKD2_k127_9460306_2 Integral membrane protein DUF92 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009957 266.0
HKD2_k127_9460306_3 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000002644 256.0
HKD2_k127_9460306_4 PFAM Di-trans-poly-cis-decaprenylcistransferase K00806 - 2.5.1.31 0.00000000000000000000000000000000000003746 150.0
HKD2_k127_9460306_5 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.000000000000000000000000000000003233 132.0
HKD2_k127_9460306_6 Putative zinc- or iron-chelating domain K06940 - - 0.00000000009101 70.0
HKD2_k127_94618_0 PFAM Xylose isomerase domain protein TIM barrel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 287.0
HKD2_k127_94618_1 RNA-binding protein of the translin family K07477 - - 0.00000000000000000000000000004442 122.0
HKD2_k127_94618_2 adenyl ribonucleotide binding - - - 0.00000000000000000000000006321 113.0
HKD2_k127_9464359_0 sugar phosphatases of the HAD superfamily K02566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002738 258.0
HKD2_k127_9509770_0 PFAM Fibronectin type III domain - - - 0.0000000000000000000000000000000000000002199 162.0
HKD2_k127_9509770_1 Chagasin family peptidase inhibitor I42 K14475 - - 0.0000001628 60.0
HKD2_k127_9513234_0 COG0058 Glucan phosphorylase K00688 - 2.4.1.1 2.264e-309 962.0
HKD2_k127_9513234_1 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004495 334.0
HKD2_k127_9513234_2 Putative TM nitroreductase - - - 0.000000000000000000000000000000000000000000000000000000002514 205.0
HKD2_k127_9513234_3 Ferredoxin K05337 - - 0.00000000000000000003606 92.0
HKD2_k127_9513234_4 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000004788 59.0
HKD2_k127_9513234_5 Chagasin family peptidase inhibitor I42 K14475 - - 0.000004526 56.0
HKD2_k127_9538446_0 oligoendopeptidase F K08602 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001292 275.0
HKD2_k127_9538446_1 Tryptophan-rich Synechocystis species C-terminal domain - - - 0.00000000000000001124 89.0
HKD2_k127_9538446_2 Lrp/AsnC ligand binding domain - - - 0.0000001514 56.0
HKD2_k127_9542698_0 DNA polymerase Ligase (LigD) - - - 0.0000000000000000000000000000000000000000000000000000000000000004845 223.0
HKD2_k127_9542698_2 PBS lyase HEAT-like repeat - - - 0.0000000000000000000001715 109.0
HKD2_k127_9542698_3 CoA binding domain - - - 0.000000000002945 68.0
HKD2_k127_9550248_0 Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P) K06984 - 2.4.2.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001542 535.0
HKD2_k127_9550248_1 Belongs to the HMG-CoA reductase family K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002912 529.0
HKD2_k127_9550248_2 Prephenate dehydratase K04518 - 4.2.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001133 311.0
HKD2_k127_9550248_3 peptidase M42 family protein - - - 0.0000000000000000000000000000000000000000000000003781 178.0
HKD2_k127_9550248_4 Non-histone chromosomal protein MC1 - - - 0.00000000000000000000000000001228 119.0
HKD2_k127_9550248_5 Glyco_18 K01183 - 3.2.1.14 0.000000000000002421 90.0
HKD2_k127_955854_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000008492 249.0
HKD2_k127_9561085_0 COG1301 Na H -dicarboxylate symporters K02030,K07862 GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - 1.008e-201 651.0
HKD2_k127_9561085_1 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000005247 132.0
HKD2_k127_9571850_0 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 291.0
HKD2_k127_9571850_1 PFAM Secreted repeat of - - - 0.000000000000000000000000000001331 125.0
HKD2_k127_9571850_2 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0002033 46.0
HKD2_k127_9581939_0 NADPH-dependent FMN reductase - - - 0.0000000000000000000000000000000000000000000000000000000000003624 219.0
HKD2_k127_9581939_1 Uncharacterized conserved protein (DUF2173) - - - 0.000000000000000000000000000006658 121.0
HKD2_k127_9581939_2 Protein of unknown function (DUF2769) - - - 0.000000000000000003686 87.0
HKD2_k127_9581939_3 4Fe-4S dicluster domain - - - 0.000000005574 58.0
HKD2_k127_9589359_0 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004637 460.0
HKD2_k127_9589359_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002575 424.0
HKD2_k127_9589359_2 Uncharacterized protein containing a ferredoxin domain (DUF2148) - - - 0.0000000000000000000000000000000000000000000000000000000000000009863 223.0
HKD2_k127_9589359_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000000000000000000000000000000000000000001324 206.0
HKD2_k127_9589359_4 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.0008989 42.0
HKD2_k127_9591597_0 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001635 476.0
HKD2_k127_9591597_1 Isocitrate lyase family K03417 - 4.1.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 328.0
HKD2_k127_9591597_2 DNA ligase K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002001 279.0
HKD2_k127_9591597_3 Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000001035 184.0
HKD2_k127_9606715_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001782 568.0
HKD2_k127_9606715_1 PFAM Radical SAM domain protein K02585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008834 406.0
HKD2_k127_9606715_10 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O K05601 GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 1.7.99.1 0.0004317 43.0
HKD2_k127_9606715_2 SMART Elongator protein 3 MiaB NifB K22226 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 346.0
HKD2_k127_9606715_3 Belongs to the precorrin methyltransferase family K02302,K02303,K13542 - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 340.0
HKD2_k127_9606715_4 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 303.0
HKD2_k127_9606715_5 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 299.0
HKD2_k127_9606715_6 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000233 304.0
HKD2_k127_9606715_7 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP K03105 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363 - 0.0000000000000001782 83.0
HKD2_k127_9606715_8 Glutathione S-transferase - - - 0.000000000001237 73.0
HKD2_k127_9606715_9 Lamin Tail Domain - - - 0.0000000002147 65.0
HKD2_k127_9622848_0 Belongs to the MCM family K10726 - - 5.954e-245 775.0
HKD2_k127_9622848_1 TIGRFAM DNA-directed RNA polymerase K03049 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000002807 236.0
HKD2_k127_9622848_2 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000000000000000000000000156 162.0
HKD2_k127_9622848_3 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000000000000608 91.0
HKD2_k127_9622848_4 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00000000000000000008588 92.0
HKD2_k127_9622848_5 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000007448 80.0
HKD2_k127_9622848_6 Protein of unknown function (DUF424) K09148 - - 0.00000000000003027 75.0
HKD2_k127_9697631_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.168e-210 664.0
HKD2_k127_9697631_1 ATP synthase alpha/beta chain, C terminal domain K02111 - 3.6.3.14 4.884e-203 644.0
HKD2_k127_9697631_2 ATP synthase K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 298.0
HKD2_k127_9697631_3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04564 - 1.15.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000655 289.0
HKD2_k127_9697631_4 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001975 268.0
HKD2_k127_9697631_5 ATP synthase, Delta/Epsilon chain, beta-sandwich domain K02114 - - 0.000000000000000000000000000000000000000000002503 167.0
HKD2_k127_9697631_6 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.00000000000000000000000000000000000000002621 162.0
HKD2_k127_9697631_7 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.000000000000000000000000000000002002 130.0
HKD2_k127_9697631_8 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.000000000000000000000000000003225 123.0
HKD2_k127_9697631_9 N-ATPase, AtpR subunit - - - 0.00000000000002278 76.0
HKD2_k127_9719169_0 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 339.0
HKD2_k127_9719169_1 TIGRFAM oxaloacetate decarboxylase alpha subunit K01960 - 6.4.1.1 0.00000000000000000000001061 103.0
HKD2_k127_9719169_2 Sporulation protein YtfJ (Spore_YtfJ) - - - 0.0000000000000000000008003 100.0
HKD2_k127_9719169_3 Protein of unknown function (DUF2953) - - - 0.00000000000000002596 89.0
HKD2_k127_9719169_4 ubiE/COQ5 methyltransferase family K07755 - 2.1.1.137 0.00000000008097 65.0
HKD2_k127_9742548_0 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.0000000000000000000000000000001482 129.0
HKD2_k127_9742548_1 Universal stress protein family - - - 0.0000000000000000000000306 104.0
HKD2_k127_9742548_2 COG2897 Rhodanese-related sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000866 79.0
HKD2_k127_9742548_3 - - - - 0.000000000608 61.0
HKD2_k127_9742548_4 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.0008902 49.0
HKD2_k127_9742799_0 Glycogen debranching enzyme - - - 8.756e-293 902.0
HKD2_k127_9742799_1 PFAM Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000005946 218.0
HKD2_k127_9742799_2 PFAM Collagen-binding surface protein Cna-like, B-type domain - - - 0.000000000007994 76.0
HKD2_k127_9806777_0 Radical SAM ThiC family K03147 - 4.1.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 446.0
HKD2_k127_9806777_1 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000002029 178.0
HKD2_k127_9806777_2 - - - - 0.00000000000000000000000000000000001273 140.0
HKD2_k127_9806777_3 - - - - 0.00000000000000007963 83.0
HKD2_k127_9806777_4 transposition, DNA-mediated - - - 0.000000000001948 70.0
HKD2_k127_9806777_5 - - - - 0.0000000221 64.0
HKD2_k127_9806777_6 transposition, DNA-mediated - - - 0.000005798 51.0
HKD2_k127_9808732_0 COG0500 SAM-dependent methyltransferases K17462 - - 0.00000000000000000000000000000000000000000000000000000008451 203.0
HKD2_k127_9808732_1 Bacterial-like globin K06886 - - 0.000000000000000000000000000000002053 132.0
HKD2_k127_9808732_2 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.000158 45.0
HKD2_k127_9913746_0 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009549 346.0
HKD2_k127_9913746_1 glyoxalase K04750 - - 0.0000000000000000000000000000000000000000000000000004404 188.0
HKD2_k127_9913746_2 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000002732 184.0
HKD2_k127_9913746_3 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000004784 92.0
HKD2_k127_9913746_4 OsmC-like protein K07397 - - 0.00000000000000000008979 93.0
HKD2_k127_9934912_0 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009013 500.0
HKD2_k127_9934912_1 CorA-like Mg2+ transporter protein K03284 GO:0000041,GO:0000287,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015087,GO:0015095,GO:0015318,GO:0015693,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0050897,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0070838,GO:0071840,GO:0071944,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903830 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005028 380.0
HKD2_k127_9934912_2 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K17870 - 1.6.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006407 321.0
HKD2_k127_9934912_3 Segregation and condensation complex subunit ScpB K06024 - - 0.000000000000000000000000000000000000000000000000000000000000000000007887 246.0
HKD2_k127_9934912_4 helix_turn_helix ASNC type K03718 - - 0.0000000000000000000000000000000000000000000000002026 180.0
HKD2_k127_9934912_5 Segregation and condensation protein ScpA K05896 - - 0.000000000000000000000000000000000000000000001692 173.0
HKD2_k127_9934912_7 Putative zinc- or iron-chelating domain K06940 - - 0.000000005965 65.0
HKD2_k127_9959230_0 Pyridine nucleotide-disulphide oxidoreductase K00382,K00383 - 1.8.1.4,1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 479.0
HKD2_k127_9959230_1 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000001292 145.0
HKD2_k127_9959230_2 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000006207 126.0
HKD2_k127_9959230_3 - - - - 0.000000000000000000009382 94.0
HKD2_k127_9997761_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 1.285e-267 836.0
HKD2_k127_9997761_1 SMART Elongator protein 3 MiaB NifB - - - 1.146e-259 812.0
HKD2_k127_9997761_10 Uncharacterized protein conserved in archaea (DUF2209) - - - 0.0000000000000000000000000005756 117.0
HKD2_k127_9997761_11 - - - - 0.000000000000000000005264 97.0
HKD2_k127_9997761_12 GXGXG motif K00202 - 1.2.7.12 0.00000000005879 72.0
HKD2_k127_9997761_13 oxidoreductase activity - - - 0.000000005958 68.0
HKD2_k127_9997761_14 associated with various cellular activities K03924 - - 0.00001306 57.0
HKD2_k127_9997761_2 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 516.0
HKD2_k127_9997761_3 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K16305 - 2.2.1.11,4.1.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 441.0
HKD2_k127_9997761_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 356.0
HKD2_k127_9997761_5 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 344.0
HKD2_k127_9997761_6 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 - 5.4.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 306.0
HKD2_k127_9997761_7 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001745 281.0
HKD2_k127_9997761_8 Belongs to the UPF0280 family K09740 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001045 256.0
HKD2_k127_9997761_9 Belongs to the glycosyl hydrolase 5 (cellulase A) family K05991 - 3.2.1.123 0.00000000000000000000000000000000000000000000002091 187.0