Overview

ID MAG01796
Name HKD2_bin.40
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Desulfobacterota_D
Class UBA1144
Order UBA2774
Family UBA2774
Genus 2-12-FULL-53-21
Species
Assembly information
Completeness (%) 78.33
Contamination (%) 2.35
GC content (%) 52.0
N50 (bp) 3,256
Genome size (bp) 2,227,480

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2280

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10007325_0 TIGRFAM penicillin-binding protein, 1A family K05366 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003153 547.0
HKD2_k127_10007325_1 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002004 279.0
HKD2_k127_10007325_2 methyltransferase - - - 0.00000000000000000004929 94.0
HKD2_k127_10007325_3 regulatory protein, FmdB family - - - 0.0000000000000000001686 93.0
HKD2_k127_10007325_4 polysaccharide export K01991,K02237 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000003871 68.0
HKD2_k127_1001500_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 1.835e-234 735.0
HKD2_k127_10035892_0 isochorismatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006001 320.0
HKD2_k127_10035892_1 Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000000000008045 157.0
HKD2_k127_1003912_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 5.036e-198 636.0
HKD2_k127_1003912_1 - - - - 0.0006137 50.0
HKD2_k127_10076108_0 Rieske-like [2Fe-2S] domain K05710,K14578 - - 0.00000000000000000000000001647 112.0
HKD2_k127_10076108_1 Tetratricopeptide repeat - - - 0.0000000000000000000000001378 109.0
HKD2_k127_10092063_0 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.0000000000000000007523 87.0
HKD2_k127_10092063_1 Transglutaminase - - - 0.00006426 53.0
HKD2_k127_1009967_0 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000001852 222.0
HKD2_k127_1009967_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 0.0000000000000000000000000000000000009987 142.0
HKD2_k127_10103102_0 Bacterial protein of unknown function (DUF899) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002005 260.0
HKD2_k127_10103102_1 glyoxalase III activity - - - 0.000000000000000000000000004215 117.0
HKD2_k127_10103102_2 - - - - 0.00000000000000000000005335 106.0
HKD2_k127_10103102_3 - - - - 0.000000000000000003003 88.0
HKD2_k127_10106941_0 ATPase associated with various cellular activities, AAA_5 K02584 - - 2.208e-208 666.0
HKD2_k127_10106941_1 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 6.406e-196 617.0
HKD2_k127_10106941_2 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005959 523.0
HKD2_k127_10106941_3 Ribulose-phosphate 3 epimerase family K01783 - 5.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000961 237.0
HKD2_k127_10106941_4 integrase domain protein SAM domain protein K03733,K04763 - - 0.00000006132 53.0
HKD2_k127_10108707_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000003572 90.0
HKD2_k127_10108707_1 Protein of unknown function (DUF2934) - - - 0.0000000001528 64.0
HKD2_k127_10110763_0 Protein of unknown function (DUF3891) - - - 0.000000000000000000000000000000343 134.0
HKD2_k127_10110763_1 FAD linked oxidases, C-terminal domain K11472 - - 0.0000000000008535 73.0
HKD2_k127_10113886_0 diguanylate cyclase - - - 0.0000000000000000000000000000000001723 141.0
HKD2_k127_10113886_1 Diguanylate cyclase, GGDEF domain - - - 0.0000000000000000000000000000000003866 142.0
HKD2_k127_10117863_0 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.0000000000000000000000002192 113.0
HKD2_k127_10117863_1 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 - 2.4.99.17 0.00000000000003877 74.0
HKD2_k127_10117863_2 Tetratricopeptide repeat - - - 0.000001346 56.0
HKD2_k127_10175134_0 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13893 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000979 386.0
HKD2_k127_10175134_1 PFAM Band 7 protein - - - 0.00000000000000000000000004247 108.0
HKD2_k127_10188629_0 PFAM Glyoxalase bleomycin resistance protein dioxygenase K15975 - - 0.0000000000000000000000000000000000000000000000003781 178.0
HKD2_k127_10188629_1 Pfam Methyltransferase - - - 0.000000000000000000000000000000000000000000000006994 180.0
HKD2_k127_10188629_2 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000002247 146.0
HKD2_k127_10188629_3 SnoaL-like domain - - - 0.0000000000000000000000000000000000001505 144.0
HKD2_k127_10188629_4 PFAM conserved - - - 0.000005945 49.0
HKD2_k127_10188984_0 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000978 226.0
HKD2_k127_10188984_1 Methyltransferase domain K15256 - - 0.000000000000000000000000000009117 128.0
HKD2_k127_10190849_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008347 428.0
HKD2_k127_10190849_1 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 311.0
HKD2_k127_10197865_0 Male sterility protein K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000654 359.0
HKD2_k127_10197865_1 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000002521 179.0
HKD2_k127_10206930_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000795 372.0
HKD2_k127_10206930_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 328.0
HKD2_k127_10206930_2 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002975 258.0
HKD2_k127_10206930_3 P-type atpase K17686 - 3.6.3.54 0.000002965 60.0
HKD2_k127_1045408_0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 466.0
HKD2_k127_1045408_1 choline dehydrogenase activity - - - 0.000000000000000000000000000000000000009178 145.0
HKD2_k127_1045408_2 NADPH-dependent FMN reductase - - - 0.0000000000000000000009367 96.0
HKD2_k127_1068908_0 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 313.0
HKD2_k127_1068908_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000003053 225.0
HKD2_k127_1068908_2 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000003596 124.0
HKD2_k127_1068908_3 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000000000000000000000000001675 115.0
HKD2_k127_1068908_4 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000001268 65.0
HKD2_k127_1091506_0 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 322.0
HKD2_k127_1091506_1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 0.00000001629 64.0
HKD2_k127_1094547_0 Peptidase dimerisation domain K13049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008281 447.0
HKD2_k127_1094547_1 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002735 362.0
HKD2_k127_1094547_10 Function of homologous gene experimentally demonstrated in an other organism K00433 - 1.11.1.10 0.000000000197 61.0
HKD2_k127_1094547_2 Serine aminopeptidase, S33 K00433 - 1.11.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 341.0
HKD2_k127_1094547_3 Protein of unknown function (DUF1211) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 292.0
HKD2_k127_1094547_4 methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 286.0
HKD2_k127_1094547_5 Ferritin-like domain K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000001737 207.0
HKD2_k127_1094547_6 PFAM Cupin 2, conserved barrel - - - 0.0000000000000000000000000000000000000000000005919 169.0
HKD2_k127_1094547_7 Function of homologous gene experimentally demonstrated in an other organism K00433 - 1.11.1.10 0.000000000000000016 82.0
HKD2_k127_1094547_8 - - - - 0.0000000000000004454 83.0
HKD2_k127_1094547_9 lipolytic protein G-D-S-L family - - - 0.0000000000001418 83.0
HKD2_k127_1117293_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 8.063e-295 919.0
HKD2_k127_1117293_1 peptidase U62 modulator of DNA gyrase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004783 444.0
HKD2_k127_1117293_2 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002967 263.0
HKD2_k127_1117293_3 major facilitator superfamily K08170 - - 0.0000000000000000000000000003639 120.0
HKD2_k127_1117293_4 Major facilitator superfamily K03446 - - 0.000000000000000000000001593 109.0
HKD2_k127_1117293_5 Protein of unknown function (DUF1232) - - - 0.000000000000000000001752 99.0
HKD2_k127_1117293_6 Major Facilitator Superfamily - - - 0.0000000001276 67.0
HKD2_k127_1117293_7 Major Facilitator Superfamily - - - 0.00000000125 60.0
HKD2_k127_1117293_8 PFAM ribosomal protein L28 K02902 - - 0.0001028 45.0
HKD2_k127_1130575_0 Dehydrogenase E1 component K00164,K01616 GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005128 438.0
HKD2_k127_1130575_1 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K00627,K00658,K09699 - 2.3.1.12,2.3.1.168,2.3.1.61 0.00000000000000000000003576 102.0
HKD2_k127_1132320_0 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 366.0
HKD2_k127_1132320_1 Glutathione S-transferase, C-terminal domain K00799,K11209 - 2.5.1.18 0.00000000000000000000000000000000000000000007274 168.0
HKD2_k127_1132320_2 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000003488 121.0
HKD2_k127_1132320_3 Thioesterase superfamily - - - 0.00000008695 57.0
HKD2_k127_1132440_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 6.946e-195 617.0
HKD2_k127_113246_0 COG1331 Highly conserved protein containing a thioredoxin domain K06888 - - 1.119e-217 687.0
HKD2_k127_113246_1 Dynamin family - GO:0000003,GO:0002682,GO:0002683,GO:0002831,GO:0002832,GO:0003006,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006996,GO:0007275,GO:0008150,GO:0009507,GO:0009526,GO:0009527,GO:0009536,GO:0009657,GO:0009668,GO:0009707,GO:0009791,GO:0009941,GO:0009987,GO:0010027,GO:0010228,GO:0010363,GO:0010941,GO:0016020,GO:0016043,GO:0019867,GO:0022414,GO:0031090,GO:0031347,GO:0031348,GO:0031967,GO:0031968,GO:0031969,GO:0031975,GO:0032101,GO:0032102,GO:0032501,GO:0032502,GO:0034051,GO:0042170,GO:0043067,GO:0043069,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043900,GO:0043901,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045088,GO:0045824,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048608,GO:0048731,GO:0048856,GO:0050776,GO:0050777,GO:0050789,GO:0050794,GO:0060548,GO:0061024,GO:0061458,GO:0065007,GO:0071840,GO:0080134,GO:0080135,GO:0098588,GO:0098805,GO:1900424,GO:1900425,GO:1902477,GO:1902478 - 0.0000000000000000000000000000000000000000003971 168.0
HKD2_k127_1171445_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000005452 183.0
HKD2_k127_1171445_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000001738 163.0
HKD2_k127_1196339_0 Putative cyclase K07130 - 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000000001077 223.0
HKD2_k127_1196339_1 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000006571 151.0
HKD2_k127_1211860_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 417.0
HKD2_k127_1219001_0 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004659 495.0
HKD2_k127_122691_0 ATPases associated with a variety of cellular activities K02006 - - 0.00000000000000000000000000000000000000000001248 168.0
HKD2_k127_122691_1 Tfp pilus assembly protein FimV - - - 0.000000000000000000000000004321 120.0
HKD2_k127_1229286_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 375.0
HKD2_k127_1232792_0 Belongs to the MlaE permease family K02066 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006544 362.0
HKD2_k127_1232792_1 PFAM ABC transporter related K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 327.0
HKD2_k127_1232792_2 - - - - 0.0000000000000000000000000000000000000000000004188 180.0
HKD2_k127_1238549_0 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000884 382.0
HKD2_k127_1238549_1 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 351.0
HKD2_k127_1287118_0 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.00000000000000000000000000000000000000000000000000000008219 210.0
HKD2_k127_1295363_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009575 388.0
HKD2_k127_1295363_1 Catalyzes the synthesis of activated sulfate K00860 - 2.7.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000822 288.0
HKD2_k127_1307871_0 PFAM peptidase - - - 0.0000000000000000000000000000000000000000000000000000000001444 216.0
HKD2_k127_1307871_1 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000006336 78.0
HKD2_k127_1307871_2 - - - - 0.000000000001725 71.0
HKD2_k127_132710_0 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.000000000000000000000000000000000000000000000000175 179.0
HKD2_k127_132710_1 Alpha-acetolactate decarboxylase K01575 - 4.1.1.5 0.000000000000000000000000000000000000003758 151.0
HKD2_k127_132710_2 Belongs to the alpha-acetolactate decarboxylase family K01575 - 4.1.1.5 0.00000000000000000000004493 102.0
HKD2_k127_132710_3 Subunit R is required for both nuclease and ATPase activities, but not for modification - - - 0.00000000004025 69.0
HKD2_k127_132710_4 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000001848 63.0
HKD2_k127_1344109_0 Belongs to the citrate synthase family K01647 - 2.3.3.1 7.852e-209 657.0
HKD2_k127_1344109_1 PFAM peptidase M50 - - - 0.000000000000000000000000000001853 124.0
HKD2_k127_134747_0 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002276 271.0
HKD2_k127_134747_1 Alpha/beta hydrolase family - - - 0.00000000000009652 81.0
HKD2_k127_1384280_0 protein histidine kinase activity K11383 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000244 389.0
HKD2_k127_1399158_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 3.928e-235 755.0
HKD2_k127_1399158_1 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 325.0
HKD2_k127_1401707_0 involved in response to NO K07234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009464 274.0
HKD2_k127_1401707_1 OsmC-like protein K04063 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 - 0.00000000000000000000000000000006005 126.0
HKD2_k127_1430609_0 Putative peptidoglycan binding domain K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006363 377.0
HKD2_k127_1430609_1 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006893 367.0
HKD2_k127_1430609_2 Putative member of DMT superfamily (DUF486) K09922 - - 0.00000000000000000000000000000000000000003082 154.0
HKD2_k127_1430609_3 Nitrite and sulphite reductase 4Fe-4S domain K00392 - 1.8.7.1 0.000002095 56.0
HKD2_k127_1430609_4 Psort location Cytoplasmic, score K01560,K07025 - 3.8.1.2 0.000006245 49.0
HKD2_k127_1456187_0 Required for maturation of 30S ribosomal subunits K09748 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000004677 147.0
HKD2_k127_1456187_1 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000009078 107.0
HKD2_k127_1463325_0 PFAM SMP-30 Gluconolaconase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001252 370.0
HKD2_k127_1466733_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006119 407.0
HKD2_k127_1466733_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002358 302.0
HKD2_k127_1466733_2 GTP cyclohydrolase I K01495 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000001182 246.0
HKD2_k127_1466733_3 PFAM Exonuclease RNase T and DNA polymerase III K02342 - 2.7.7.7 0.000000000000000000000000000000000000001666 157.0
HKD2_k127_1466733_5 - - - - 0.00000003341 56.0
HKD2_k127_1466733_6 Psort location Cytoplasmic, score 8.96 - - - 0.00006381 46.0
HKD2_k127_1481677_0 Isochorismatase family - - - 0.00000000000000000000000000000000000000000000000002034 185.0
HKD2_k127_1481677_1 Protein of unknown function (DUF559) - - - 0.00000000000000000000001477 101.0
HKD2_k127_1484790_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004305 456.0
HKD2_k127_1484790_1 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000002484 174.0
HKD2_k127_1491667_0 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K03841 - 3.1.3.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007837 486.0
HKD2_k127_1491667_1 Putative exonuclease SbcCD, C subunit K03546 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006213 472.0
HKD2_k127_1491667_2 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.00000000000000000000000000000000000002152 149.0
HKD2_k127_1491667_3 PFAM Colicin V production protein K03558 - - 0.0000000005937 68.0
HKD2_k127_1497068_0 ASPIC and UnbV - - - 0.00000000000000000000000000000000000000000000000009259 190.0
HKD2_k127_1497068_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000003303 171.0
HKD2_k127_1505281_0 phosphoenolpyruvate-dependent sugar phosphotransferase system K02768,K02769,K02770 - 2.7.1.202 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008639 366.0
HKD2_k127_1505281_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000009738 108.0
HKD2_k127_1513196_0 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002145 269.0
HKD2_k127_1525092_0 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0000000000000000000000000000000000000000000000001756 181.0
HKD2_k127_1525092_1 Nitroreductase family - - - 0.0000000000000000000000000000001797 128.0
HKD2_k127_1546360_0 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.000000000000000000000000000000000000002632 152.0
HKD2_k127_1546360_1 Evidence 2a Function of homologous gene experimentally demonstrated in an other organism K00928,K12524 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 0.000000000000000000000000000000000001973 141.0
HKD2_k127_1546360_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000009904 81.0
HKD2_k127_1556238_0 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components 2- oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) K00164 - 1.2.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 407.0
HKD2_k127_1556238_1 ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002677 377.0
HKD2_k127_1556238_2 PFAM thiamine pyrophosphate protein domain protein TPP-binding K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000001266 234.0
HKD2_k127_1565150_0 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006728 546.0
HKD2_k127_1565150_1 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 456.0
HKD2_k127_1565150_2 protein conserved in bacteria containing thioredoxin-like domain - - - 0.00000000000000000000000000000000000000000000003484 179.0
HKD2_k127_1604501_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 4.793e-318 996.0
HKD2_k127_1604501_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114 1.2.7.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006209 497.0
HKD2_k127_1604501_2 oxidoreductase activity, acting on CH-OH group of donors - - - 0.000000000000000000000000000000000000000000000000000000007732 207.0
HKD2_k127_1611945_0 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003362 390.0
HKD2_k127_1616679_0 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029,K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 365.0
HKD2_k127_1616679_1 proteolysis - - - 0.00000000000000000000000000000007229 128.0
HKD2_k127_1634918_0 - K19341 - - 0.00000000000000000000000000000000000000000000000000000000000000000476 235.0
HKD2_k127_1634918_1 NosL K19342 - - 0.0000000000000000000001231 107.0
HKD2_k127_1634918_2 Bacterial regulatory proteins, tetR family - - - 0.0000000000000003548 86.0
HKD2_k127_1645156_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 547.0
HKD2_k127_1645156_1 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 491.0
HKD2_k127_1645156_2 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.00000000000000000000000000000001168 137.0
HKD2_k127_1645962_0 D-Ala-D-Ala carboxypeptidase 3 (S13) family K01286,K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004512 561.0
HKD2_k127_1645962_1 - - - - 0.00000000000000000006071 94.0
HKD2_k127_1645962_2 amine dehydrogenase activity - - - 0.000001328 51.0
HKD2_k127_1648346_0 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 301.0
HKD2_k127_1648346_1 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000006162 224.0
HKD2_k127_1661762_0 oligoendopeptidase F K08602 - - 3.076e-200 640.0
HKD2_k127_1661762_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 522.0
HKD2_k127_1661762_2 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000006304 233.0
HKD2_k127_1661762_3 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000007743 194.0
HKD2_k127_1661762_4 GatB Yqey domain protein K09117 - - 0.00000000000000000000000000000000003412 139.0
HKD2_k127_1661762_5 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.00000000000000000000000000002366 120.0
HKD2_k127_1672999_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 1.795e-271 843.0
HKD2_k127_1672999_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005826 491.0
HKD2_k127_1688186_0 acetyltransferases and hydrolases with the alpha beta hydrolase fold K00650 - 2.3.1.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006599 438.0
HKD2_k127_1688186_1 Protein of unknown function (DUF1152) - - - 0.00000000000000004062 83.0
HKD2_k127_1705920_0 acetyl-coa acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003825 360.0
HKD2_k127_1705920_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000004598 244.0
HKD2_k127_1705920_2 Sporulation initiation inhibitor protein Soj K03496 - - 0.0000000000000000000000000000000000000000000000000000004012 203.0
HKD2_k127_1705920_3 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000008475 144.0
HKD2_k127_1705920_4 glyoxalase III activity - - - 0.0000000000000000000000000000000001084 139.0
HKD2_k127_1705920_5 Rubredoxin-like zinc ribbon domain (DUF35_N) K07068 - - 0.0000000000000000000000000000002212 129.0
HKD2_k127_1705920_6 Replication initiation and membrane attachment K02086 - - 0.0002232 53.0
HKD2_k127_1724818_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005728 478.0
HKD2_k127_1727499_0 gluconolactonase activity K01053 - 3.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002269 584.0
HKD2_k127_1727499_1 Cupin 2, conserved barrel domain protein K11477 - - 0.00000000000000000022 89.0
HKD2_k127_1727499_2 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000000000145 69.0
HKD2_k127_1729585_0 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009242 561.0
HKD2_k127_1729585_1 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000449 117.0
HKD2_k127_1729585_2 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198 - 0.0000000000000000000000000005815 116.0
HKD2_k127_1729585_3 Belongs to the 'phage' integrase family - - - 0.000001828 51.0
HKD2_k127_1734216_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 4.83e-250 786.0
HKD2_k127_1734216_1 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K13941 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15,2.7.6.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000005773 273.0
HKD2_k127_1734216_2 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.00000000000000000000000000000000000000000000000000000000000000000000002416 250.0
HKD2_k127_1734216_3 PFAM YbbR family protein - - - 0.000000000000006721 80.0
HKD2_k127_1738053_0 VWA domain containing CoxE-like protein K09989 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000232 546.0
HKD2_k127_1738053_1 AAA domain (dynein-related subfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 422.0
HKD2_k127_1738053_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000007855 161.0
HKD2_k127_17592_0 Voltage gated chloride channel K03281 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 383.0
HKD2_k127_1792722_0 Domain of unknown function (DUF4336) - - - 0.000000000000000000000000000000000000000000000000001662 192.0
HKD2_k127_1792722_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.000000000000000000000000001904 119.0
HKD2_k127_1792722_2 PFAM blue (type 1) copper domain protein - - - 0.00000000000000005728 85.0
HKD2_k127_1794119_0 B12 binding domain - - - 5.636e-198 635.0
HKD2_k127_1794119_1 rRNA (guanine-N2-)-methyltransferase activity K13604,K21460 GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009987,GO:0015994,GO:0015995,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0030493,GO:0030494,GO:0032259,GO:0033013,GO:0033014,GO:0034641,GO:0036067,GO:0036069,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.304,2.1.1.333 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003702 413.0
HKD2_k127_1794119_2 Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions K02553 GO:0003674,GO:0004857,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008428,GO:0009892,GO:0009894,GO:0009895,GO:0010605,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031324,GO:0031329,GO:0031330,GO:0032069,GO:0032074,GO:0043086,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:1902369 - 0.00000000000000000000000000000000000000000000000000000000000000000002771 238.0
HKD2_k127_1794119_3 phosphohistidine phosphatase, SixA K08296 - - 0.0000000000000002334 80.0
HKD2_k127_1795819_0 PFAM RNA polymerase sigma factor 54, interaction - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 508.0
HKD2_k127_1795819_1 Glycogen debranching enzyme - - - 0.000000000000000000000000000000000000000000000000000000007024 201.0
HKD2_k127_1814361_0 chaperone-mediated protein folding - - - 0.00000000000000000000000000000000000000000000000000000000000000009847 240.0
HKD2_k127_1821443_0 Belongs to the ClpA ClpB family K03694 - - 9.672e-264 831.0
HKD2_k127_1821443_2 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.00000000000000000000000000001315 121.0
HKD2_k127_1821443_3 Transcription factor zinc-finger K09981 - - 0.0000000000007706 76.0
HKD2_k127_1822316_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003227 621.0
HKD2_k127_1822316_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 419.0
HKD2_k127_1869316_0 Pfam Transposase IS66 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002307 340.0
HKD2_k127_1869316_1 FOG TPR repeat, SEL1 subfamily K07126,K13582 - - 0.0000003754 61.0
HKD2_k127_1869316_2 xyloglucan:xyloglucosyl transferase activity - - - 0.00001227 57.0
HKD2_k127_1874220_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.00000000000000000000000000000000000000000000004966 172.0
HKD2_k127_1875313_0 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004077 383.0
HKD2_k127_1875313_1 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000007523 87.0
HKD2_k127_1875313_2 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000002081 59.0
HKD2_k127_1876786_0 Belongs to the pseudouridine synthase RsuA family K06178 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005924 296.0
HKD2_k127_1876786_1 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000004633 203.0
HKD2_k127_1876786_2 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.0000000000000000000000000000000000000000000002017 174.0
HKD2_k127_1876786_3 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.0000000000000000000000000000000000000001626 152.0
HKD2_k127_1877628_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008972 482.0
HKD2_k127_1877628_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000004197 79.0
HKD2_k127_1886774_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001398 282.0
HKD2_k127_1886774_1 - - - - 0.000000000002792 68.0
HKD2_k127_1896800_0 PHP domain protein K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000006947 192.0
HKD2_k127_1896800_1 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000000004426 177.0
HKD2_k127_1896800_2 Domain of unknown function (DUF1844) - - - 0.0001475 44.0
HKD2_k127_191779_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274,K02298 - 1.10.3.10,1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006579 455.0
HKD2_k127_191779_1 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275,K17223 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008214 314.0
HKD2_k127_191779_2 signal sequence binding K07152 - - 0.0000000000000000000000000000000000000000000000000000002478 201.0
HKD2_k127_1918005_0 tail specific protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 541.0
HKD2_k127_1918005_1 oligopeptide transport system permease protein OppB K15581 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004214 265.0
HKD2_k127_1933549_0 Involved in the biosynthesis of porphyrin-containing compound - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002366 290.0
HKD2_k127_1933549_1 Protein of unknown function (DUF1285) K09986 - - 0.0000000000000001592 83.0
HKD2_k127_1933549_2 PFAM outer membrane efflux protein - - - 0.00000922 57.0
HKD2_k127_1945206_0 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000001146 250.0
HKD2_k127_1945206_1 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000004892 80.0
HKD2_k127_1972102_0 Belongs to the thiolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 323.0
HKD2_k127_1972102_1 NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000007423 219.0
HKD2_k127_1972102_2 Acetoacetate decarboxylase (ADC) - - - 0.00000002739 65.0
HKD2_k127_1972102_3 Acetoacetate decarboxylase (ADC) - - - 0.000198 53.0
HKD2_k127_1976146_0 methylmalonyl-CoA mutase N-terminal domain K01847 - 5.4.99.2 1.302e-256 797.0
HKD2_k127_1976662_0 PFAM aldo keto reductase K05275 - 1.1.1.65 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001575 524.0
HKD2_k127_1976662_1 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005326 392.0
HKD2_k127_1976662_2 AraC-like ligand binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003214 255.0
HKD2_k127_1976662_3 Uncharacterized protein conserved in bacteria (DUF2255) - - - 0.00000000000000000000000000000000000001096 147.0
HKD2_k127_1976662_4 alcohol dehydrogenase K12957 - - 0.000215 44.0
HKD2_k127_20123_0 PFAM UbiA prenyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000001187 227.0
HKD2_k127_20123_1 protein conserved in bacteria - - - 0.000000000000000000002787 106.0
HKD2_k127_20123_2 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000134 60.0
HKD2_k127_2012597_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1095.0
HKD2_k127_2012597_1 PFAM Acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000001629 211.0
HKD2_k127_2012597_2 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.0000000000000000000000000000000000000163 158.0
HKD2_k127_2014634_0 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K07083,K11785 - - 0.000000000000000000000000000000000000000000000000008179 191.0
HKD2_k127_2014634_1 - - - - 0.00000000000000008396 91.0
HKD2_k127_204652_0 DEAD DEAH box helicase K03724 - - 2.327e-319 997.0
HKD2_k127_204652_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000000000003529 68.0
HKD2_k127_2053568_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 1.983e-214 685.0
HKD2_k127_2053568_1 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.000000000000000000000000000004446 122.0
HKD2_k127_2053568_2 DNA polymerase X family K02347 - - 0.000000000000000000005131 94.0
HKD2_k127_205575_0 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005084 364.0
HKD2_k127_205575_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 364.0
HKD2_k127_205575_2 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002126 271.0
HKD2_k127_205575_3 Divergent polysaccharide deacetylase K09798 - - 0.00000000000000000000000000000000000000000000000079 191.0
HKD2_k127_205575_4 Belongs to the bacterial ribosomal protein bS21 family K02970 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000009005 81.0
HKD2_k127_2079566_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 563.0
HKD2_k127_2115694_0 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000004142 218.0
HKD2_k127_2115694_1 RmlD substrate binding domain K08679 - 5.1.3.6 0.00000000007717 63.0
HKD2_k127_211617_0 threonine synthase activity K01733 - 4.2.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005008 595.0
HKD2_k127_211617_1 B12 binding domain K00548 - 2.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004535 505.0
HKD2_k127_211617_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.0000000000000000000000000000000000000000000000000004315 189.0
HKD2_k127_211617_3 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000004576 180.0
HKD2_k127_211617_4 Molybdopterin converting factor, small subunit K03636 - - 0.00000000000000000000000000000001105 128.0
HKD2_k127_2116346_0 PFAM cobalamin adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000003218 175.0
HKD2_k127_2116346_1 Belongs to the thioredoxin family K03671 - - 0.00000000000000000000000000000000000009842 143.0
HKD2_k127_2118484_0 tpr repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002455 273.0
HKD2_k127_2118484_1 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000003534 205.0
HKD2_k127_2118484_3 PBS lyase - - - 0.0000008941 59.0
HKD2_k127_2132305_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001354 287.0
HKD2_k127_2132305_1 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000001279 187.0
HKD2_k127_2132305_2 Mycobacterial 4 TMS phage holin, superfamily IV K08972 - - 0.000000000000000000001048 98.0
HKD2_k127_2138220_0 Belongs to the TPP enzyme family K01568 - 4.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002791 374.0
HKD2_k127_2138220_1 oxidoreductase activity, acting on CH-OH group of donors K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 339.0
HKD2_k127_2138220_2 M42 glutamyl aminopeptidase - - - 0.0000000000000000000000000000001564 127.0
HKD2_k127_2138220_3 Antibiotic biosynthesis monooxygenase - - - 0.00000000000003361 77.0
HKD2_k127_2147554_0 two component, sigma54 specific, transcriptional regulator, Fis family K02667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006438 311.0
HKD2_k127_2147554_1 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000006336 272.0
HKD2_k127_2147554_2 PFAM type II secretion system K02653 - - 0.00000000000000000000000000000000000000000000000000000000009718 211.0
HKD2_k127_216030_0 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 451.0
HKD2_k127_216030_1 Belongs to the peptidase M16 family K07263 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003926 458.0
HKD2_k127_216030_2 Protein of unknown function (DUF475) K09799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008132 398.0
HKD2_k127_216030_3 Aldose 1-epimerase K01792 - 5.1.3.15 0.00000000000000000000000000000000000000000000000000456 190.0
HKD2_k127_216030_4 RHS Repeat - - - 0.000000000000000000000001059 106.0
HKD2_k127_216030_5 Belongs to the glucose-6-phosphate 1-epimerase family K01792 - 5.1.3.15 0.00000000000000000000006774 101.0
HKD2_k127_21643_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004039 337.0
HKD2_k127_21643_1 D-alanyl-D-alanine carboxypeptidase K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000002354 274.0
HKD2_k127_21643_2 HAD-hyrolase-like K07025 - - 0.000000000000000000006202 101.0
HKD2_k127_21643_3 General secretion pathway protein C K02452 - - 0.00001096 55.0
HKD2_k127_2179620_0 Belongs to the CarB family K01955 - 6.3.5.5 1.21e-210 664.0
HKD2_k127_2179620_1 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.00000000000000000000000000000000000000000000005396 173.0
HKD2_k127_2179620_2 - - - - 0.00000000000000000000000000000000000000000003756 170.0
HKD2_k127_2179620_3 peptidyl-tyrosine sulfation - - - 0.000000000000000000000000000003139 133.0
HKD2_k127_2179620_4 ABC-type multidrug transport system ATPase component K01990 - - 0.0000000000168 69.0
HKD2_k127_2185948_0 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006432 319.0
HKD2_k127_2185948_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000001305 238.0
HKD2_k127_2185948_2 helix_turn_helix, mercury resistance - - - 0.000000000000000001503 93.0
HKD2_k127_2191624_0 Domain of unknown function (DUF4388) - - - 0.00000009299 64.0
HKD2_k127_2205000_0 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000328 228.0
HKD2_k127_2205000_1 Tetratricopeptide repeat - - - 0.0000001318 62.0
HKD2_k127_2205000_2 Curli production assembly/transport component CsgG - - - 0.00005191 55.0
HKD2_k127_2206439_0 twitching motility protein K02669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004221 515.0
HKD2_k127_2206439_1 Type II secretion system K02653 - - 0.00000000000000000000000000000000000000000005098 164.0
HKD2_k127_2206439_2 General secretory system II, protein E domain protein K02652 - - 0.00000000000000000000000214 104.0
HKD2_k127_2218847_0 Response receiver-modulated cyclic diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000002778 226.0
HKD2_k127_2218847_1 Fe-S oxidoreductases K22227 - - 0.00000000000000000000000000000000000000000000000000000000000001714 223.0
HKD2_k127_2245118_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 6.229e-211 664.0
HKD2_k127_2245118_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004294 295.0
HKD2_k127_2245118_2 Aconitase C-terminal domain K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005788 278.0
HKD2_k127_2245118_3 Protein of unknown function (DUF2905) - - - 0.0000000000000000001545 90.0
HKD2_k127_2260053_0 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000008925 188.0
HKD2_k127_2260053_1 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000002589 117.0
HKD2_k127_2263128_0 Bacterial virulence protein (VirJ) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 317.0
HKD2_k127_2263128_1 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000009402 77.0
HKD2_k127_2286220_0 Isocitrate lyase K01637 GO:0003674,GO:0003824,GO:0004451,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0006102,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046421,GO:0046487,GO:0071704,GO:0072350 4.1.3.1 1.904e-267 853.0
HKD2_k127_2286220_1 Malate synthase K01638 - 2.3.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 601.0
HKD2_k127_2289238_0 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001489 467.0
HKD2_k127_2289238_1 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.000000000000000000000000000000000000000000000000003464 190.0
HKD2_k127_2289238_2 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.0000000000001549 70.0
HKD2_k127_2295563_0 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000003071 181.0
HKD2_k127_2295563_1 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000007974 94.0
HKD2_k127_2310422_0 PFAM aldo keto reductase - - - 0.0000000000000000000005069 97.0
HKD2_k127_2310422_1 - - - - 0.00000000000000004151 90.0
HKD2_k127_2337121_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 6.6e-227 715.0
HKD2_k127_2343229_0 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000091 224.0
HKD2_k127_2343229_1 protein conserved in bacteria - - - 0.000000000000004279 88.0
HKD2_k127_235592_0 addiction module antidote protein HigA K21498 - - 0.00000000000000000000000000000000000000000001959 166.0
HKD2_k127_235592_1 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.000000000000000000000000000000000003242 138.0
HKD2_k127_235592_2 phage integrase domain protein SAM domain protein - - - 0.000000001123 61.0
HKD2_k127_2358236_0 PFAM Cytochrome c assembly protein K02198 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006438 590.0
HKD2_k127_2358236_1 zinc-ribbon domain - - - 0.0000000000009867 76.0
HKD2_k127_2358236_2 nitrite reductase K00368 - 1.7.2.1 0.0001019 55.0
HKD2_k127_2358686_0 TIGRFAM acetolactate synthase, large subunit, biosynthetic type K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000542 382.0
HKD2_k127_2358686_1 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003343 303.0
HKD2_k127_2358686_2 ACT domain K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000002872 199.0
HKD2_k127_2366387_0 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 545.0
HKD2_k127_2366387_1 DNA-3-methyladenine glycosylase K01246 - 3.2.2.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 284.0
HKD2_k127_2366387_2 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000006054 230.0
HKD2_k127_2366387_3 Cupin 2, conserved barrel domain protein - - - 0.0000000000000001414 79.0
HKD2_k127_2385755_0 LssY C-terminus - - - 0.0000000000000000000000000000000000000000001678 169.0
HKD2_k127_2385755_1 LssY C-terminus - - - 0.00000000000000000000000001078 111.0
HKD2_k127_2429117_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0 1312.0
HKD2_k127_2429117_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004851 463.0
HKD2_k127_2450877_0 Glycosyl transferase, family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006986 293.0
HKD2_k127_2450877_1 symporter activity K03307 - - 0.000000000000000000000000000000000000000000000000000000006348 207.0
HKD2_k127_2450877_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000004567 141.0
HKD2_k127_2458360_0 PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004827 563.0
HKD2_k127_2458360_1 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000833 134.0
HKD2_k127_2475679_0 Enoyl-CoA hydratase/isomerase K01661,K07536 - 4.1.3.36 0.000000000000000000000000000000000000000000000000000000000000000000000001142 254.0
HKD2_k127_2475679_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K17228 - 1.14.14.35 0.0000000000000000000000000000000000000000000000000000000003342 210.0
HKD2_k127_2475679_2 Gliding motility-associated protein GldC - - - 0.000000000000000000000005214 109.0
HKD2_k127_2497593_0 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.0000000000000000000000000000000000000000000000000007824 193.0
HKD2_k127_2497593_1 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000000000000000006422 186.0
HKD2_k127_2497593_2 COG1145 Ferredoxin - - - 0.00000007087 61.0
HKD2_k127_2508235_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000002289 237.0
HKD2_k127_2524631_0 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003551 430.0
HKD2_k127_2524631_1 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 420.0
HKD2_k127_2524631_2 Elongator protein 3, MiaB family, Radical SAM K11779 - 2.5.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000109 347.0
HKD2_k127_2524631_3 Belongs to the ClpX chaperone family K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 331.0
HKD2_k127_252669_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002788 301.0
HKD2_k127_252669_1 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.000000000000000000000000000000000000002716 149.0
HKD2_k127_252669_2 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000006872 136.0
HKD2_k127_252669_3 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000006463 58.0
HKD2_k127_255255_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 411.0
HKD2_k127_255255_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002362 314.0
HKD2_k127_255255_2 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000006802 147.0
HKD2_k127_255255_3 Belongs to the glycosyl hydrolase family 6 K01181 - 3.2.1.8 0.00000007956 58.0
HKD2_k127_2583838_0 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000644 187.0
HKD2_k127_2583838_1 sodium:proton antiporter activity K03316 - - 0.0000000000000000000000000000000000000000001575 165.0
HKD2_k127_2583838_2 - - - - 0.00000001793 58.0
HKD2_k127_2583838_3 Fusaric acid resistance protein-like K15547 - - 0.000002557 59.0
HKD2_k127_2598704_0 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 502.0
HKD2_k127_2598704_1 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007689 325.0
HKD2_k127_259964_0 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000004725 95.0
HKD2_k127_2612539_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00528 - 1.18.1.2,1.19.1.1 0.0000000000000000000000000000000000000003638 153.0
HKD2_k127_2612539_1 PFAM Ribonuclease II K01147 - 3.1.13.1 0.00000000000000000000000000000000000001698 154.0
HKD2_k127_2642761_0 Carbamoyltransferase C-terminus K00612 - - 3.7e-268 840.0
HKD2_k127_2642761_1 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.000000000000000000000000000000000000000000000000000000003028 205.0
HKD2_k127_2642761_2 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03644,K03801 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181,2.8.1.8 0.00000000000000000000000000000000000000000000002527 179.0
HKD2_k127_2642761_3 - - - - 0.00000000001872 67.0
HKD2_k127_2642761_4 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000282 70.0
HKD2_k127_2642761_5 Lysin motif K06194 - - 0.000000006469 69.0
HKD2_k127_2642761_6 - - - - 0.00000006636 55.0
HKD2_k127_2662495_0 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005219 282.0
HKD2_k127_2662495_1 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.0000000000000000000000009624 109.0
HKD2_k127_2670057_0 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 6.858e-202 640.0
HKD2_k127_2670057_1 CarD-like/TRCF domain K07736 - - 0.0000000000000000000000000000000000000000000006465 171.0
HKD2_k127_2670057_2 protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000001798 164.0
HKD2_k127_2694120_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 3.739e-213 677.0
HKD2_k127_2694120_1 RNA ligase activity K14415 GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 6.5.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 602.0
HKD2_k127_2694120_2 PHB de-polymerase C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007703 300.0
HKD2_k127_2694120_3 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 - - 0.0000000000000000000000000000000000000000000000006911 181.0
HKD2_k127_2696256_0 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 353.0
HKD2_k127_2696256_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000361 268.0
HKD2_k127_2696256_2 TRAM domain K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000002297 271.0
HKD2_k127_2696256_3 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000007759 187.0
HKD2_k127_2696256_4 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 - 6.3.4.5 0.0000000000000000000000000000000002082 133.0
HKD2_k127_2711849_0 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001822 282.0
HKD2_k127_2711849_1 4-hydroxybenzoate polyprenyltransferase K03179 - 2.5.1.39 0.0000000000000000000000000000000000000000000000000000000000002977 221.0
HKD2_k127_271490_1 - - - - 0.0000005104 60.0
HKD2_k127_273371_0 ABC-type multidrug transport system, ATPase and permease components K18890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 416.0
HKD2_k127_273371_1 dihydrofolate reductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 319.0
HKD2_k127_273371_2 GHMP kinases C terminal K00849 - 2.7.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000005487 259.0
HKD2_k127_273371_3 MobA-like NTP transferase domain K00973 - 2.7.7.24 0.000000000000000000000000000000000000000000001483 174.0
HKD2_k127_273371_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000001017 150.0
HKD2_k127_273371_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000003912 109.0
HKD2_k127_2752184_0 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000655 283.0
HKD2_k127_2752184_1 Cation transporter/ATPase, N-terminus K01531 - 3.6.3.2 0.0000000000000000000000000000000000000000000000000000000000001435 219.0
HKD2_k127_2755977_0 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009675 424.0
HKD2_k127_2755977_1 pfam abc K05847 - - 0.000000000000000000000000000009214 119.0
HKD2_k127_2768785_0 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003303 411.0
HKD2_k127_2768785_1 PFAM Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000502 405.0
HKD2_k127_2768785_2 Belongs to the ABC transporter superfamily K02031,K02032,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 390.0
HKD2_k127_2768785_3 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000679 348.0
HKD2_k127_2768785_4 Uncharacterized ACR, COG1399 K07040 - - 0.000000000005559 71.0
HKD2_k127_2769052_0 PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic K01886 - 6.1.1.18 5.547e-268 834.0
HKD2_k127_2769052_1 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000002641 134.0
HKD2_k127_2769052_2 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K01905,K11175,K22224 - 2.1.2.2,6.2.1.13 0.00000000000000000000000000005028 126.0
HKD2_k127_2769052_3 Belongs to the ALAD family K01698 - 4.2.1.24 0.00004587 46.0
HKD2_k127_277179_0 Histidine-specific methyltransferase, SAM-dependent - - - 0.0000000000000000000000000000000000000000000000007206 183.0
HKD2_k127_277179_1 DNA alkylation repair enzyme - - - 0.0001643 45.0
HKD2_k127_2830047_0 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000006468 215.0
HKD2_k127_2830047_1 RNA polymerase sigma factor K03088 - - 0.000000000000000000000000000004133 124.0
HKD2_k127_2842867_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 455.0
HKD2_k127_2842867_1 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000004804 96.0
HKD2_k127_2842867_2 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.00000000002398 73.0
HKD2_k127_2842867_3 ATP synthesis coupled proton transport K02109 GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0016020,GO:0016469,GO:0032991,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 - 0.000000002774 66.0
HKD2_k127_2847521_0 Major Facilitator Superfamily - - - 0.0000000000000000001819 101.0
HKD2_k127_2847521_1 Major Facilitator Superfamily - - - 0.0003054 47.0
HKD2_k127_2865849_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000006818 216.0
HKD2_k127_2865849_1 Na dependent nucleoside transporter K03317 - - 0.00000000000000000000000000000000000000000000000005242 181.0
HKD2_k127_2865849_2 transcriptional regulator K16137 - - 0.000000000000000000000000000000000000000000001237 172.0
HKD2_k127_2865849_3 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.00000000000000000000000000000000000009498 144.0
HKD2_k127_2865849_4 PFAM sigma-70 region 2 domain protein K03088 - - 0.0000000000000000000000000000008263 130.0
HKD2_k127_2876543_0 proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001048 574.0
HKD2_k127_2876543_1 ATPase associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008425 432.0
HKD2_k127_2876543_2 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 368.0
HKD2_k127_2876543_3 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 357.0
HKD2_k127_2876543_4 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000819 348.0
HKD2_k127_2876543_5 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 317.0
HKD2_k127_2876543_6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.00000000000000000000000000000000000000000000000000000000000000000001835 236.0
HKD2_k127_2876543_7 Belongs to the Fur family K03711,K09825 - - 0.0000000000000000000000000002817 119.0
HKD2_k127_2876543_8 Domain of unknown function (DUF4175) - - - 0.000000000000000003275 97.0
HKD2_k127_2876543_9 - - - - 0.000000000000003214 79.0
HKD2_k127_2886093_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 434.0
HKD2_k127_2886093_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006898 276.0
HKD2_k127_2886093_2 copper resistance K07245,K14166 - - 0.000000000000000000000000000000000000000000003053 176.0
HKD2_k127_2886093_3 response to copper ion K07156,K14166 - - 0.00000000000000000000000000000009792 128.0
HKD2_k127_2886093_4 Copper chaperone PCu(A)C K09796 - - 0.0000000000000000000000000001825 120.0
HKD2_k127_2886093_5 - - - - 0.0000000000000000000000003515 106.0
HKD2_k127_2886093_6 - - - - 0.000003222 49.0
HKD2_k127_2886093_7 - - - - 0.0006689 46.0
HKD2_k127_2888119_0 ROK family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000003313 213.0
HKD2_k127_2888119_1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000001118 96.0
HKD2_k127_2896898_0 Helix-turn-helix XRE-family like proteins - - - 0.000000000000000000006145 101.0
HKD2_k127_2896898_1 RDD family - - - 0.0000000000000000006313 94.0
HKD2_k127_2896898_2 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000001598 64.0
HKD2_k127_2939870_0 Belongs to the SOS response-associated peptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000001799 222.0
HKD2_k127_2939870_1 - - - - 0.00000000000000000000000000000000000000000000000000002296 190.0
HKD2_k127_2939870_2 - - - - 0.00000000000000000000000000000000000002159 150.0
HKD2_k127_2939870_3 - - - - 0.0000000000000000000000000000000001474 138.0
HKD2_k127_2939870_5 Hint domain - - - 0.0003097 51.0
HKD2_k127_2947602_0 Glycosyl hydrolase family 67 C-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 505.0
HKD2_k127_295161_0 Succinyl-CoA synthetase, alpha subunit K02381 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 297.0
HKD2_k127_295161_1 CoA-ligase - - - 0.000000000000000002551 89.0
HKD2_k127_2953579_0 Haloacid dehalogenase-like hydrolase K19270 - 3.1.3.23 0.00000000000000000000000000000000000000000000000000003398 196.0
HKD2_k127_2953579_1 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000421 180.0
HKD2_k127_2953579_2 Phosphoglucose isomerase K01810,K13810 - 2.2.1.2,5.3.1.9 0.00000000000000000000000000000000000000000000287 168.0
HKD2_k127_300796_0 ATPase associated with various cellular activities, AAA_5 K02584 - - 0.00000000000000000000000000000000000000000000000000002243 198.0
HKD2_k127_300796_1 COG2346, Truncated hemoglobins K06886 - - 0.0000000000000000000000000004131 121.0
HKD2_k127_300796_2 - - - - 0.0000000000000000000000004487 107.0
HKD2_k127_3007995_0 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.000000000000000000000000000000000000000000000000000000000000000000000207 245.0
HKD2_k127_3007995_1 Glycoside hydrolase family 3 K01207 - 3.2.1.52 0.00000000000000000000000000000000000000000000000000000000000000005386 239.0
HKD2_k127_3010576_0 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K06879,K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000007361 160.0
HKD2_k127_3010576_1 PFAM OmpA MotB domain protein K03640 - - 0.000000005776 64.0
HKD2_k127_3031323_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001173 248.0
HKD2_k127_3031323_1 PFAM Integrase catalytic region - - - 0.000000000003094 68.0
HKD2_k127_3038678_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 417.0
HKD2_k127_3046973_0 membrane K07058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001974 325.0
HKD2_k127_3046973_1 Belongs to the helicase family. UvrD subfamily - - - 0.00000000000000000000000000000000000000000000000000005643 198.0
HKD2_k127_3046973_2 CVNH domain - - - 0.0000000000000000000000000000000000000006438 154.0
HKD2_k127_3046973_3 FR47-like protein K03789 - 2.3.1.128 0.0008731 44.0
HKD2_k127_3050196_0 Sulfatase-modifying factor enzyme 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000147 559.0
HKD2_k127_3050196_1 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 367.0
HKD2_k127_3050196_2 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765,K02502 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000244 196.0
HKD2_k127_3072307_0 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000000000001092 121.0
HKD2_k127_3072307_1 RadC-like JAB domain K03630 - - 0.000000000000000000001221 97.0
HKD2_k127_3072307_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 0.000000000000000000327 88.0
HKD2_k127_307806_0 Bulb-type mannose-specific lectin - - - 0.000000005347 66.0
HKD2_k127_3081684_0 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001446 490.0
HKD2_k127_3081684_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000009234 99.0
HKD2_k127_3101508_0 MOFRL family K11529 - 2.7.1.165 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 521.0
HKD2_k127_3101508_1 Beta-eliminating lyase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004594 286.0
HKD2_k127_3101508_2 NTPase - - - 0.0000000000000000000000000000000000000000005774 163.0
HKD2_k127_3101508_3 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.000000812 53.0
HKD2_k127_3153519_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 531.0
HKD2_k127_3153519_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 2.1.1.198 0.000000000000000000000000000000000000000000000000004042 188.0
HKD2_k127_3170345_0 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000003595 213.0
HKD2_k127_3170345_1 membrane protein (DUF2207) - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000161 205.0
HKD2_k127_3170345_2 Protein of unknown function (DUF1015) - - - 0.00000000001281 66.0
HKD2_k127_3171876_0 PFAM glycosyl transferase family 51 K05367 - 2.4.1.129 7.634e-208 666.0
HKD2_k127_3171876_1 Cytochrome c mono- and diheme variants - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004676 282.0
HKD2_k127_3171876_2 cytochrome p450 - - - 0.000000000000000000000000000000002764 129.0
HKD2_k127_317538_0 PFAM Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 294.0
HKD2_k127_3176588_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 354.0
HKD2_k127_317987_0 NUBPL iron-transfer P-loop NTPase K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004235 321.0
HKD2_k127_317987_1 Peptidase family M23 - - - 0.000000000000001577 83.0
HKD2_k127_324381_0 Oxidoreductase family, NAD-binding Rossmann fold K00118,K13020 - 1.1.1.335,1.1.99.28 0.000000000000000000000000006725 119.0
HKD2_k127_324381_1 Thermolysin metallopeptidase, catalytic domain K01400 - 3.4.24.28 0.0001106 54.0
HKD2_k127_326087_0 PFAM Acetyltransferase (GNAT) family K03830 - - 0.0000000000000000000000000000003657 128.0
HKD2_k127_326087_1 Putative metal-binding domain of cation transport ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.000000001277 61.0
HKD2_k127_326087_2 UPF0056 membrane protein K05595 - - 0.0000002742 54.0
HKD2_k127_3276579_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006371 395.0
HKD2_k127_3276579_1 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001205 255.0
HKD2_k127_3276579_2 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000917 118.0
HKD2_k127_3276579_3 Cytochrome c K12263 - - 0.000000000000000001257 90.0
HKD2_k127_3298476_0 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000584 239.0
HKD2_k127_3298476_1 PFAM Phosphoribosyltransferase - - - 0.0000000000000000000000000000000000001745 150.0
HKD2_k127_3298476_2 Type IV pilus assembly protein PilM; K02461 - - 0.000000001934 67.0
HKD2_k127_3338088_0 diacylglycerol kinase, catalytic - - - 0.000000000000000000000000000000000000000000000005719 183.0
HKD2_k127_3338088_1 Dual specificity phosphatase, catalytic domain - - - 0.00000000000000000000000000000002018 134.0
HKD2_k127_3338088_2 - - - - 0.00000001446 60.0
HKD2_k127_3368601_0 phosphate acetyltransferase K00625,K00634 - 2.3.1.19,2.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 494.0
HKD2_k127_3368601_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 304.0
HKD2_k127_3370088_0 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K00850,K00895,K21071 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002079 460.0
HKD2_k127_3370088_1 PFAM Rhomboid family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000002368 232.0
HKD2_k127_3370088_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.000000000000000000000000000000000001025 144.0
HKD2_k127_3370088_3 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.000001155 57.0
HKD2_k127_3370088_4 Lytic transglycosylase, SLT, LysM and LysM domain-containing K08307 - - 0.0003865 49.0
HKD2_k127_337078_0 Vacuole effluxer Atg22 like K06902 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 479.0
HKD2_k127_337078_1 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004082 443.0
HKD2_k127_337078_2 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 422.0
HKD2_k127_337078_3 2-hydroxychromene-2-carboxylate isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000008219 233.0
HKD2_k127_337078_4 Iron-storage protein K02217 - 1.16.3.2 0.000000000000000000000000000000000000000000000000001356 186.0
HKD2_k127_337078_5 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate K03330 GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.7 0.000005952 54.0
HKD2_k127_3382441_0 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000002539 246.0
HKD2_k127_3382441_1 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000000005192 198.0
HKD2_k127_3382441_2 cog cog1253 K03699 - - 0.00007671 46.0
HKD2_k127_3401903_0 transferase activity, transferring glycosyl groups K13693 - 2.4.1.266 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 522.0
HKD2_k127_3401903_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005389 499.0
HKD2_k127_3401903_2 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000001038 273.0
HKD2_k127_3401903_3 haloacid dehalogenase-like hydrolase K05947,K07026 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050897 2.4.1.217,3.1.3.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000307 269.0
HKD2_k127_3401903_4 helix_turn_helix, mercury resistance - - - 0.000000000000000000000005605 104.0
HKD2_k127_3409142_0 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003191 460.0
HKD2_k127_3409142_1 TIGRFAM sugar-phosphate isomerase, RpiB LacA LacB family K01808 - 5.3.1.6 0.000000000000000000000000000000000000000000000000002124 186.0
HKD2_k127_3409142_2 Uncharacterized ACR, COG1993 K09137 - - 0.00001349 47.0
HKD2_k127_3410912_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005659 388.0
HKD2_k127_3410912_1 binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000002771 145.0
HKD2_k127_3417142_0 ABC-type polysaccharide polyol phosphate transport system ATPase component K09691 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001543 426.0
HKD2_k127_3417142_1 Polysaccharide deacetylase - - - 0.00000000000000000021 93.0
HKD2_k127_3419756_0 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 541.0
HKD2_k127_3419756_1 ADP-glyceromanno-heptose 6-epimerase activity K08678 - 4.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008611 320.0
HKD2_k127_3419756_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002906 261.0
HKD2_k127_3419756_3 3-beta hydroxysteroid dehydrogenase/isomerase family K01710,K08678 - 4.1.1.35,4.2.1.46 0.0000000000000000000000000000000000000000000000000000000000002995 213.0
HKD2_k127_3419756_4 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000003007 167.0
HKD2_k127_3428680_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007315 435.0
HKD2_k127_3466423_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 423.0
HKD2_k127_3466423_1 gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.0000000000001795 71.0
HKD2_k127_3468957_0 Molecular chaperone. Has ATPase activity K04079 - - 0.000000000000000000000000000000000000000000000000000000000000000000008947 239.0
HKD2_k127_3476807_0 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002286 314.0
HKD2_k127_3476807_1 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000678 198.0
HKD2_k127_3498081_0 HD domain - - - 0.00000000000000000000000000000000000000000000000000000002535 218.0
HKD2_k127_3498081_1 response regulator - - - 0.00000000000000000000002182 102.0
HKD2_k127_3500911_0 Protein of unknown function (DUF1254) - - - 7.987e-200 632.0
HKD2_k127_3500911_1 membrane transporter protein K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 366.0
HKD2_k127_3500911_2 COGs COG0491 Zn-dependent hydrolase including glyoxylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 330.0
HKD2_k127_3500911_3 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000001607 199.0
HKD2_k127_3500911_4 Protein of unknown function (DUF1254) - - - 0.00000000000000000000000000000000000002711 148.0
HKD2_k127_3500911_5 Protein of unknown function (DUF1634) - - - 0.0000000000000000000000005995 109.0
HKD2_k127_3500911_6 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000001408 87.0
HKD2_k127_3506407_0 Soluble lytic murein transglycosylase-like protein - - - 0.0000000000000000000000000000000005632 141.0
HKD2_k127_3506407_1 Reverse transcriptase-like K03469,K06864 - 3.1.26.4 0.0000000000000000000000000000001068 129.0
HKD2_k127_3506407_2 C4-type zinc ribbon domain K07164 - - 0.00000000000000000000000001927 118.0
HKD2_k127_3506407_3 - - - - 0.000002905 53.0
HKD2_k127_3506407_4 - - - - 0.00003134 48.0
HKD2_k127_351184_0 HELICc2 K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001607 596.0
HKD2_k127_351184_1 Protein of unknown function (DUF4256) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005851 331.0
HKD2_k127_3529073_0 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003482 314.0
HKD2_k127_3538658_0 PFAM ABC transporter related K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005939 293.0
HKD2_k127_3538658_1 TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000109 235.0
HKD2_k127_3538658_2 Binding-protein-dependent transport system inner membrane component K02050,K15552 - - 0.0000000000000000002326 90.0
HKD2_k127_3549875_0 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000007839 147.0
HKD2_k127_3549875_1 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.00000000000000000000000000000000003046 143.0
HKD2_k127_3549875_2 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 0.00000006579 54.0
HKD2_k127_3561398_0 Pyruvate kinase K00873 - 2.7.1.40 2.315e-201 647.0
HKD2_k127_3561398_1 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism K01488,K21053 - 3.5.4.2,3.5.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 436.0
HKD2_k127_3583132_0 Psort location CytoplasmicMembrane, score - - - 0.0000000000000000000004112 98.0
HKD2_k127_3587730_0 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 332.0
HKD2_k127_3587730_1 PFAM Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000004042 213.0
HKD2_k127_3587730_2 KR domain K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000000000000000000000000000000000000000000000144 193.0
HKD2_k127_3587730_3 Enoyl-(Acyl carrier protein) reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.000000000000000000000000000000001363 130.0
HKD2_k127_3587730_4 pyridoxamine 5'-phosphate K07005 - - 0.000000000000000000000000000003059 123.0
HKD2_k127_3587730_5 KR domain - - - 0.000000000009172 66.0
HKD2_k127_3603974_1 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion - - - 0.0005123 51.0
HKD2_k127_3630577_0 Membrane bound O-acyl transferase family - - - 0.0000000000000000000000000000000000000000000000000000002935 204.0
HKD2_k127_3630577_1 3'(2'),5'-bisphosphate nucleotidase activity K01082,K01092 - 3.1.3.25,3.1.3.7 0.00000000000000000000003422 102.0
HKD2_k127_3630577_2 CAAX protease self-immunity K07052 - - 0.000001059 58.0
HKD2_k127_3633155_0 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000002122 199.0
HKD2_k127_3633155_1 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.0000000000000000000000000000000000009578 141.0
HKD2_k127_3633155_3 Threonyl and Alanyl tRNA synthetase second additional domain K01868 GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 0.00000000003018 65.0
HKD2_k127_3633155_4 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.0000000003624 63.0
HKD2_k127_3633515_0 - - - - 0.0000000000000000000000000000000000000000000000001877 186.0
HKD2_k127_3646225_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007313 445.0
HKD2_k127_3646225_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760,K15780 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8,6.3.4.19 0.00002197 50.0
HKD2_k127_3657758_0 PFAM Alcohol dehydrogenase, zinc-binding K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 366.0
HKD2_k127_3657758_1 associated with various cellular activities K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001492 331.0
HKD2_k127_3663174_0 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005447 325.0
HKD2_k127_3663174_1 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000002691 158.0
HKD2_k127_3663174_2 Thrombospondin type 3 repeat K03286 - - 0.00000000000000000000000008645 113.0
HKD2_k127_3663174_4 F420H(2)-dependent quinone reductase - - - 0.0002073 50.0
HKD2_k127_3663174_5 - - - - 0.0003668 48.0
HKD2_k127_3673787_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 9.541e-231 734.0
HKD2_k127_3673787_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086,K03089 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000066 287.0
HKD2_k127_3694276_0 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K07218 - - 0.000000000000000000000000000000000000000000000000000000000000835 219.0
HKD2_k127_3694276_1 Domain present in carbohydrate binding proteins and sugar hydrolses K07218 - - 0.0000000002195 64.0
HKD2_k127_3717817_0 Aminotransferase class I and II K10206 - 2.6.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002565 514.0
HKD2_k127_3717817_1 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 503.0
HKD2_k127_3717817_2 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002785 289.0
HKD2_k127_3717817_3 Acyl-transferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000002086 190.0
HKD2_k127_3724605_0 Methionine synthase B12-binding module cap domain protein K00548 - 2.1.1.13 0.0 1170.0
HKD2_k127_3724605_1 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 324.0
HKD2_k127_3724605_2 phosphatase activity K07025 - - 0.00000000000000000000000000000000000000000000000002472 187.0
HKD2_k127_3724605_3 - - - - 0.00000000000000005817 81.0
HKD2_k127_3724605_4 - - - - 0.00000000000007962 77.0
HKD2_k127_3747073_0 PFAM Aminotransferase class I and II K00639,K00652,K01906 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47,6.2.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007521 396.0
HKD2_k127_3747073_1 Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor K00833 - 2.6.1.62 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007 389.0
HKD2_k127_3747073_2 Ndr family K00433,K01055 - 1.11.1.10,3.1.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000004637 249.0
HKD2_k127_3747073_3 PFAM Carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.0000000000000000009435 88.0
HKD2_k127_3748535_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 544.0
HKD2_k127_3748535_1 glucose sorbosone K00117 - 1.1.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000685 392.0
HKD2_k127_3748535_2 Belongs to the UPF0173 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001475 298.0
HKD2_k127_3748535_3 histidine kinase A domain protein K02482 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000003689 190.0
HKD2_k127_3748535_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000008899 174.0
HKD2_k127_3748535_5 Archease protein family (MTH1598/TM1083) - - - 0.000000000000000000000000188 110.0
HKD2_k127_3749303_0 Belongs to the UPF0061 (SELO) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 396.0
HKD2_k127_3749303_1 metal-binding protein (DUF2103) - - - 0.00000000000004773 76.0
HKD2_k127_3751915_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 576.0
HKD2_k127_3751915_1 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000000000000000003529 231.0
HKD2_k127_3751915_2 Kazal type serine protease inhibitors - - - 0.00000000000000000000000000000000000002422 151.0
HKD2_k127_3751915_3 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.000000004474 59.0
HKD2_k127_3751915_4 Thaumatin family - - - 0.0003512 47.0
HKD2_k127_375989_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009026 532.0
HKD2_k127_375989_1 YbbR-like protein - - - 0.00001093 54.0
HKD2_k127_3793165_0 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007134 545.0
HKD2_k127_3793165_1 Biotin-lipoyl like K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 342.0
HKD2_k127_3793165_2 Rhodanese domain protein - - - 0.0000000000000000000002328 98.0
HKD2_k127_3795435_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 314.0
HKD2_k127_3795435_1 F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000001711 237.0
HKD2_k127_3795435_2 PFAM ribosomal protein L17 K02879 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000001995 152.0
HKD2_k127_3795435_3 Domain of unknown function (DUF1731) K07071 - - 0.00000000000000000000000008051 109.0
HKD2_k127_3813445_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002402 359.0
HKD2_k127_3813445_1 D-isomer specific 2-hydroxyacid dehydrogenase catalytic region K00015 - 1.1.1.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009767 306.0
HKD2_k127_3813445_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000148 266.0
HKD2_k127_3813445_3 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000008809 265.0
HKD2_k127_3813445_4 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000008478 248.0
HKD2_k127_3813445_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001372 255.0
HKD2_k127_3813445_6 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000000000000000000000000000000002092 164.0
HKD2_k127_3813445_7 PA domain - - - 0.0000000000000000000000000000000000000002118 158.0
HKD2_k127_3813445_8 - - - - 0.000000000000001078 87.0
HKD2_k127_3827846_0 PFAM Glycosyl transferase family 2 K00694 - 2.4.1.12 6.457e-196 620.0
HKD2_k127_3851342_0 Protoporphyrinogen oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 578.0
HKD2_k127_3851342_1 Flavin containing amine oxidoreductase - - - 0.00002069 51.0
HKD2_k127_3851342_2 ABC transporter transmembrane region K06147,K11085 - - 0.0001715 53.0
HKD2_k127_3886818_0 Cytochrome b(N-terminal)/b6/petB K00412 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 559.0
HKD2_k127_3886818_1 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004549 286.0
HKD2_k127_3886818_2 cytochrome c oxidase K02862 - - 0.0000000000000000000000000000000000000000000000000000000001253 214.0
HKD2_k127_3886818_3 PFAM Rieske 2Fe-2S domain protein - - - 0.0000000000000000000000000000000000000000000000000000000002744 206.0
HKD2_k127_3886818_4 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000001073 168.0
HKD2_k127_3886818_5 NADH dehydrogenase K03885 - 1.6.99.3 0.0000000000002309 71.0
HKD2_k127_3896511_0 Phosphate acetyl/butaryl transferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005326 260.0
HKD2_k127_3896511_1 PFAM Phosphate-selective porin O and P - - - 0.0000000000000000000000000000000000002724 158.0
HKD2_k127_3896511_2 Cupin - - - 0.000000000000000000000000000000003827 132.0
HKD2_k127_3896511_3 Cupin - - - 0.00000000000000000000000005901 112.0
HKD2_k127_3914860_0 poly(R)-hydroxyalkanoic acid synthase K03821 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003184 397.0
HKD2_k127_3914860_1 reductase K00059 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000001161 258.0
HKD2_k127_3914860_2 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000001189 245.0
HKD2_k127_3914860_3 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - 0.0002511 49.0
HKD2_k127_3918006_0 protein histidine kinase activity K11383 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000245 263.0
HKD2_k127_3918006_1 PFAM Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000002269 190.0
HKD2_k127_394112_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 404.0
HKD2_k127_394112_1 Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005607 402.0
HKD2_k127_394112_2 Glycosyl transferase, family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002153 266.0
HKD2_k127_394112_3 regulation of translation K03530 - - 0.0000000000000000000000000001641 119.0
HKD2_k127_394112_4 cheY-homologous receiver domain - - - 0.00000000000000000000005478 103.0
HKD2_k127_394112_5 - - - - 0.0000000000000000000001407 104.0
HKD2_k127_394112_6 phosphoesterase, PA-phosphatase related - - - 0.00003125 52.0
HKD2_k127_3946062_0 Acts as a magnesium transporter K06213 - - 0.000000000000000000000000000000000000000000000000000000000003974 211.0
HKD2_k127_3946062_1 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000002238 157.0
HKD2_k127_3946062_2 Putative ATP-dependant zinc protease - - - 0.0000000000000000000000000000000000005642 146.0
HKD2_k127_3946062_3 efflux transmembrane transporter activity K12340 - - 0.00000000000000000000000000000029 134.0
HKD2_k127_3962174_0 Pfam Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000003441 230.0
HKD2_k127_3962174_1 Protein of unknown function (DUF3341) - - - 0.00000000000000000000000000000000006019 139.0
HKD2_k127_3962174_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000006074 111.0
HKD2_k127_3962174_3 Polysulphide reductase, NrfD K00185 - - 0.00007062 45.0
HKD2_k127_3962286_0 Cupin K01569 - 4.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 361.0
HKD2_k127_3962286_1 - - - - 0.00000006584 62.0
HKD2_k127_3963438_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 1.48e-213 670.0
HKD2_k127_3963438_1 domain protein - - - 0.000000000000000000000000000000000000000000000000000001403 199.0
HKD2_k127_3963438_2 Acylphosphatase K01512 - 3.6.1.7 0.00000000000000000000000001655 111.0
HKD2_k127_397308_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 418.0
HKD2_k127_3984959_1 - - - - 0.0000000000000000000000002574 116.0
HKD2_k127_4016528_0 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008108 395.0
HKD2_k127_4016528_1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000000000000262 210.0
HKD2_k127_4016528_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000623 93.0
HKD2_k127_4016528_3 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000004486 61.0
HKD2_k127_4054966_0 Glycosyltransferase Family 4 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008843 269.0
HKD2_k127_4054966_1 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.000000003315 59.0
HKD2_k127_4056062_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 425.0
HKD2_k127_4056062_1 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000004561 87.0
HKD2_k127_4058124_0 Carboxymuconolactone decarboxylase family - - - 0.00000000000000006191 88.0
HKD2_k127_4058124_1 Transport permease protein K01992 - - 0.00000000002794 63.0
HKD2_k127_407436_0 Domain of unknown function (DUF4396) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 345.0
HKD2_k127_407436_1 Putative regulatory protein - - - 0.0000000000000000000000000000000000000000000000000001677 190.0
HKD2_k127_4092546_0 Cell division inhibitor - - - 0.000000000000000000000000000000000000000000000000001472 187.0
HKD2_k127_4092546_1 SEC-C Motif Domain Protein - - - 0.0000000002988 66.0
HKD2_k127_4099949_0 4 iron, 4 sulfur cluster binding K07139 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464,GO:0048037,GO:0051536,GO:0051539,GO:0051540 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 345.0
HKD2_k127_4099949_1 FES K10773 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 0.000000000000000000000000000000000000000000001397 168.0
HKD2_k127_4099949_2 response regulator, receiver - - - 0.000000000000000000001169 101.0
HKD2_k127_414368_0 PFAM FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 336.0
HKD2_k127_414368_1 Methyltransferase type 11 K15256 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 301.0
HKD2_k127_414368_2 MarC family integral membrane protein K05595 - - 0.000000000000000000000000000000002436 134.0
HKD2_k127_414368_3 Acetyltransferase (GNAT) domain K03830 - - 0.000000000000000000000000000001062 127.0
HKD2_k127_414368_4 SpoIIAA-like - - - 0.0000000000000000000000000001091 121.0
HKD2_k127_4154690_0 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009916 563.0
HKD2_k127_4154690_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 480.0
HKD2_k127_4154690_2 PhoH-like protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 400.0
HKD2_k127_4154690_3 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002684 285.0
HKD2_k127_4161113_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 554.0
HKD2_k127_4161113_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003137 357.0
HKD2_k127_4161113_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07799,K18901 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005553 273.0
HKD2_k127_4161113_3 Belongs to the TrpC family K01609 - 4.1.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000004487 258.0
HKD2_k127_4161113_4 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000002814 236.0
HKD2_k127_4161113_5 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.000000000000000000000000000000000000000000000000001336 187.0
HKD2_k127_4161113_6 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000003376 179.0
HKD2_k127_4161113_7 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.000000000000000000000000000000001297 134.0
HKD2_k127_4161113_8 PFAM TM2 domain containing protein - - - 0.000003982 53.0
HKD2_k127_4161113_9 Protein of unknown function (DUF3426) - - - 0.00001259 57.0
HKD2_k127_4165981_0 Belongs to the heme-copper respiratory oxidase family K00404,K15862 - 1.9.3.1 0.0 1060.0
HKD2_k127_4165981_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 460.0
HKD2_k127_4165981_2 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000004284 280.0
HKD2_k127_4165981_3 N-terminal domain of cytochrome oxidase-cbb3, FixP K00406 - - 0.0000000000000000000000000000000000000000000003119 173.0
HKD2_k127_4165981_4 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.00000000000000000000000000000159 130.0
HKD2_k127_4165981_5 Cytochrome oxidase maturation protein - - - 0.00000000006578 66.0
HKD2_k127_4173234_0 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007569 415.0
HKD2_k127_4173234_1 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0000000000000000000000000000000000000000000000000000000003496 221.0
HKD2_k127_4183035_0 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001821 428.0
HKD2_k127_4183130_0 Transglutaminase-like superfamily K22452 - 2.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000249 265.0
HKD2_k127_4183130_1 Heavy-metal resistance - - - 0.000000009479 62.0
HKD2_k127_4183130_2 Putative zinc-finger - - - 0.00001191 54.0
HKD2_k127_4183130_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00002997 47.0
HKD2_k127_4185319_0 amino acid carrier protein K03310 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002087 271.0
HKD2_k127_4185319_1 Inositol monophosphatase K01092 - 3.1.3.25 0.00000000000000000000000000000000000000000000003359 179.0
HKD2_k127_4190128_0 NAD synthase K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 394.0
HKD2_k127_4190128_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000038 135.0
HKD2_k127_4190128_2 CAAX protease self-immunity K07052 - - 0.0000001108 61.0
HKD2_k127_4211593_0 4Fe-4S dicluster domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006623 495.0
HKD2_k127_4211593_1 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000103 153.0
HKD2_k127_4218141_0 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003495 310.0
HKD2_k127_4218141_1 PFAM glycosyl transferase family 51 K05367 - 2.4.1.129 0.00000000000000000000008364 101.0
HKD2_k127_4219126_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000003436 209.0
HKD2_k127_4222758_0 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000002248 188.0
HKD2_k127_4223422_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000006967 143.0
HKD2_k127_4223422_1 Prokaryotic dksA/traR C4-type zinc finger - - - 0.00000000000000000004142 93.0
HKD2_k127_4223422_2 STAS domain - - - 0.0000000000000000001378 93.0
HKD2_k127_4223422_3 - - - - 0.00000134 55.0
HKD2_k127_4232513_0 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002624 273.0
HKD2_k127_4232513_1 PFAM 2Fe-2S iron-sulfur cluster binding domain - - - 0.00001323 47.0
HKD2_k127_4241102_0 Sulfatase K01137 - 3.1.6.14 0.0000000000000000000000000000000000000000000008399 175.0
HKD2_k127_4241102_1 long-chain fatty acid transporting porin activity - - - 0.0000000000000000000000000002596 123.0
HKD2_k127_4241102_2 - - - - 0.000002095 50.0
HKD2_k127_4243049_0 PFAM Aminotransferase class-III K00821 - 2.6.1.11,2.6.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005778 427.0
HKD2_k127_4243049_1 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 341.0
HKD2_k127_4243049_2 Belongs to the ATCase OTCase family K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007909 316.0
HKD2_k127_4248822_0 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004802 329.0
HKD2_k127_4248822_1 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001333 265.0
HKD2_k127_4248822_2 Tfp pilus assembly protein FimV - - - 0.000000000000000000000000000000000000000000000000000000000000000006932 243.0
HKD2_k127_4248822_3 domain, Protein K21449 - - 0.0000000006215 63.0
HKD2_k127_4254802_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005712 593.0
HKD2_k127_4254802_1 Isocitrate/isopropylmalate dehydrogenase K00031 - 1.1.1.42 0.00000000000000000000000000000000000000000000000000000000000000000002751 235.0
HKD2_k127_4263954_0 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007404 327.0
HKD2_k127_4263954_1 Papain-like cysteine protease AvrRpt2 - - - 0.00000000000000000000000000000000000002728 149.0
HKD2_k127_4263954_2 Conserved hypothetical protein 95 - - - 0.00000000000000000000000000004198 124.0
HKD2_k127_4263954_3 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 GO:0003674,GO:0003824,GO:0004595,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 0.00000000000000000000009683 98.0
HKD2_k127_4263954_4 Tetratricopeptide repeat - - - 0.00000000000000000004518 98.0
HKD2_k127_4263954_5 - - - - 0.00000000000148 73.0
HKD2_k127_4291466_0 Type II secretion system (T2SS), protein F K02455,K02653 - - 0.0000000000000000000000000000000000000000000000000000000002117 210.0
HKD2_k127_4291466_1 general secretion pathway protein G K02456 - - 0.0000000000000000000000000000000000003059 144.0
HKD2_k127_4291466_3 General secretion pathway protein K02459 GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776 - 0.000000003273 66.0
HKD2_k127_4291466_4 general secretion pathway protein K02246,K02247,K02456,K02457,K02458,K10924 - - 0.0000005755 58.0
HKD2_k127_4291466_5 Type II secretion system (T2SS), protein K K02460 - - 0.00002442 53.0
HKD2_k127_4293662_0 Catalyzes the oxidation of malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008267 465.0
HKD2_k127_4293662_1 Phosphohydrolase-associated domain K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004253 412.0
HKD2_k127_4293662_2 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 294.0
HKD2_k127_4293662_3 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11782 - 4.2.1.151 0.000000000000000000000000000000000000001515 157.0
HKD2_k127_4328200_0 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005491 286.0
HKD2_k127_4334888_0 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000004202 182.0
HKD2_k127_4334888_1 Belongs to the peptidase S8 family - - - 0.00005652 54.0
HKD2_k127_4361186_0 TIGRFAM Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 350.0
HKD2_k127_4361186_1 Sporulation related domain - - - 0.00000001873 64.0
HKD2_k127_4372584_0 Phosphoserine phosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008715 492.0
HKD2_k127_4372584_1 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 354.0
HKD2_k127_4372584_2 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000001183 52.0
HKD2_k127_4376494_0 Elongation factor Tu domain 2 K02355 - - 9.275e-215 685.0
HKD2_k127_438920_0 AMP-binding enzyme C-terminal domain K00666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008456 512.0
HKD2_k127_438920_1 atpase related to the helicase subunit of the holliday junction resolvase K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 482.0
HKD2_k127_438920_2 Lactoylglutathione lyase K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000003439 195.0
HKD2_k127_438920_3 MaoC like domain - - - 0.000000000000000002189 88.0
HKD2_k127_4392860_0 major facilitator superfamily - - - 0.000000000000000000000000000001201 133.0
HKD2_k127_4397946_0 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003824 461.0
HKD2_k127_4397946_1 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - GO:0003674,GO:0003824,GO:0003850,GO:0004346,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0044237,GO:0050308,GO:0050309 - 0.0000000000000000000000000000000000000006811 156.0
HKD2_k127_4402231_0 Belongs to the transketolase family K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 577.0
HKD2_k127_4402231_1 FAD linked oxidase domain protein K06911 - - 0.00000000000000000000000000000000000000000000000000001888 205.0
HKD2_k127_44253_0 4-alpha-glucanotransferase K00705 - 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 557.0
HKD2_k127_4431564_0 General secretory system II, protein E domain protein K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003072 607.0
HKD2_k127_4467042_0 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 559.0
HKD2_k127_4469620_0 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.0000000000000000000000000000001113 129.0
HKD2_k127_4469620_1 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.000000000000000000000000000002149 126.0
HKD2_k127_447188_0 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000009871 214.0
HKD2_k127_447188_1 of ABC-type glycine betaine transport system K05845,K05846 - - 0.00000000000000000000000000000000000001842 145.0
HKD2_k127_447188_2 - - - - 0.000000000000000000278 96.0
HKD2_k127_447188_3 Transferase hexapeptide repeat - - - 0.00004802 47.0
HKD2_k127_4476547_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 587.0
HKD2_k127_4476547_1 Sodium transporter K03453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 300.0
HKD2_k127_4476547_2 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000002845 193.0
HKD2_k127_4476547_3 LysE type translocator - - - 0.000000000000000000000000000000000000004502 153.0
HKD2_k127_4476547_4 EamA-like transporter family - - - 0.00000001246 66.0
HKD2_k127_4479722_0 Cupin superfamily (DUF985) K09705 - - 0.000000000000000000000000000000000000000000000000297 182.0
HKD2_k127_4479722_1 Hsp20/alpha crystallin family K13993 - - 0.000008339 49.0
HKD2_k127_4486699_0 Butirosin biosynthesis protein H, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000004963 223.0
HKD2_k127_4486699_1 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000001102 173.0
HKD2_k127_4486699_2 PFAM HAS barrel domain - - - 0.000000000004231 69.0
HKD2_k127_4486699_3 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00002074 47.0
HKD2_k127_4514638_0 ABC transporter K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000000000000002139 231.0
HKD2_k127_4514638_1 Cytochrome C assembly protein K02195 - - 0.0000000000000000000000000000000000000000000000000000000000001597 219.0
HKD2_k127_4514638_2 PFAM cytochrome c-type biogenesis protein CcmB K02194 - - 0.000000000000000000000000000000000000000000000000000001306 199.0
HKD2_k127_4514638_3 3-beta hydroxysteroid dehydrogenase - - - 0.00000000000000002874 87.0
HKD2_k127_4516419_0 Sigma-54 interaction domain K07714,K07715 - - 0.0000000000000000000000000000000000000000000000000000000000000005371 227.0
HKD2_k127_4516419_1 Histidine kinase K02482,K14986 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000001154 208.0
HKD2_k127_4516419_2 phosphinothricin N-acetyltransferase activity - - - 0.00000000000000000000000003273 116.0
HKD2_k127_4517544_0 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001166 301.0
HKD2_k127_4517544_1 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 291.0
HKD2_k127_4517544_2 Alpha beta hydrolase K00433,K01055 - 1.11.1.10,3.1.1.24 0.00000000000000000000000000000000000000000000000000000002206 206.0
HKD2_k127_4517544_3 Haloacid dehalogenase-like hydrolase K02566 - - 0.000000000000000000000000000000000000000000000000007102 190.0
HKD2_k127_4517544_4 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000001643 186.0
HKD2_k127_4517544_5 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.000000000000000000000000000000000000000004011 160.0
HKD2_k127_4517544_6 COG2893 Phosphotransferase system, mannose fructose-specific component IIA K02793 - 2.7.1.191 0.000000000000000000000000000000001051 134.0
HKD2_k127_4517544_7 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase K05808 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - 0.000000578 54.0
HKD2_k127_4541277_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008986 310.0
HKD2_k127_4546281_0 Major facilitator Superfamily - GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000002792 220.0
HKD2_k127_4546281_1 von Willebrand factor (vWF) type A domain - - - 0.0000000000007915 76.0
HKD2_k127_4548349_0 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004445 569.0
HKD2_k127_4558127_0 PFAM 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 586.0
HKD2_k127_4558127_1 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000002672 154.0
HKD2_k127_4580299_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 531.0
HKD2_k127_4580756_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 2.227e-199 633.0
HKD2_k127_4580756_1 MlaD protein K02067 - - 0.000000000001221 72.0
HKD2_k127_4591460_0 Flagellar Motor Protein K02557 - - 0.0000000000000000000000000000000000000000001873 165.0
HKD2_k127_4591460_1 Short chain dehydrogenase - - - 0.00000000000000000000000002692 111.0
HKD2_k127_4623430_0 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000001475 164.0
HKD2_k127_4623430_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000002817 80.0
HKD2_k127_462957_0 TIGRFAM glutamate synthases, NADH NADPH, small subunit K00266 - 1.4.1.13,1.4.1.14 7.747e-250 778.0
HKD2_k127_462957_1 glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 488.0
HKD2_k127_462957_2 Belongs to the aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002825 403.0
HKD2_k127_4644136_0 PFAM Cysteine-rich domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 305.0
HKD2_k127_4644136_1 - - - - 0.000000000000000001117 90.0
HKD2_k127_4646500_0 Nitrous oxide reductase K00376 - 1.7.2.4 2.016e-295 921.0
HKD2_k127_4646500_1 lipoprotein involved in nitrous oxide reduction K19342 - - 0.00000000000000000000000000000000000000000000005686 172.0
HKD2_k127_4646500_2 Cytochrome C oxidase, cbb3-type, subunit III K02305 - - 0.00000000000000000000005177 102.0
HKD2_k127_4646500_3 Cytochrome C oxidase subunit II, periplasmic domain K00376 - 1.7.2.4 0.0005777 48.0
HKD2_k127_4650893_0 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001048 277.0
HKD2_k127_4650893_1 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.000000000000000000000000000000000001255 141.0
HKD2_k127_4650893_2 HELICc2 K03722 - 3.6.4.12 0.00000000000000000000009151 99.0
HKD2_k127_4652994_0 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K00666,K18660 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 579.0
HKD2_k127_4660042_0 Phosphorylase superfamily K01243 - 3.2.2.9 0.00000000000000000000000000000000000000000000000000000000000000000001067 240.0
HKD2_k127_4660042_1 - - - - 0.0000000000000000000000000000000000000000005105 163.0
HKD2_k127_4660042_2 Methyltransferase FkbM domain - - - 0.000000000000000000000000000000003495 139.0
HKD2_k127_4660042_3 Histidine kinase-like ATPase domain - - - 0.0000000000000000000396 92.0
HKD2_k127_4664726_0 Aminotransferase class I and II K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003891 389.0
HKD2_k127_4664726_1 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000004698 192.0
HKD2_k127_4666198_0 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000006441 214.0
HKD2_k127_4666198_1 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000005135 99.0
HKD2_k127_4666198_2 methyltransferase - - - 0.000000001186 68.0
HKD2_k127_4672383_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000731 548.0
HKD2_k127_4672383_1 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - 0.0000000000000000000000000000000001884 135.0
HKD2_k127_4672383_2 Belongs to the UPF0102 family K07460 - - 0.00000000000000000006758 93.0
HKD2_k127_4672383_3 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 0.00000006579 54.0
HKD2_k127_4682932_0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008868 329.0
HKD2_k127_4682932_1 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000182 234.0
HKD2_k127_4682932_2 oxidoreductase activity - - - 0.000000000000000000000000000000000000000000000000000000009305 207.0
HKD2_k127_4682932_3 Protein of unknown function (DUF1275) - - - 0.00000000000000000000000000000000000000000000000001318 187.0
HKD2_k127_4682932_4 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000003981 174.0
HKD2_k127_4682932_5 Pyridoxal-phosphate dependent enzyme K01697,K01738 - 2.5.1.47,4.2.1.22 0.00000000000000000000000000000000000000000002763 166.0
HKD2_k127_4682932_6 lipolytic protein G-D-S-L family - - - 0.000001738 58.0
HKD2_k127_468474_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000004019 176.0
HKD2_k127_468474_1 HEAT repeats - - - 0.00006488 55.0
HKD2_k127_4690935_0 PFAM Class I peptide chain release factor - - - 0.000000000000000000000000971 108.0
HKD2_k127_4690935_1 Glycosyltransferase family 87 - - - 0.00000000000000000000001553 104.0
HKD2_k127_4690935_2 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000005555 101.0
HKD2_k127_4690935_3 Belongs to the BolA IbaG family - - - 0.0000000000001428 77.0
HKD2_k127_4701814_0 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000000000000000008195 235.0
HKD2_k127_4701814_1 - - - - 0.00000000000001146 74.0
HKD2_k127_4701814_2 PFAM phosphoesterase - - - 0.00000000000172 68.0
HKD2_k127_4701814_3 - - - - 0.000000002175 61.0
HKD2_k127_4717738_0 2 heme-binding sites K00428 - 1.11.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000303 450.0
HKD2_k127_4717738_1 glutamate dehydrogenase [NAD(P)+] activity K00261,K00262 - 1.4.1.3,1.4.1.4 0.00000000000000000000000002723 111.0
HKD2_k127_472087_0 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008338 485.0
HKD2_k127_472087_1 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 370.0
HKD2_k127_472087_2 Peptidogalycan biosysnthesis/recognition K09919 - - 0.0000000000000000000000000000000000000000000000000000000004181 212.0
HKD2_k127_472087_3 oxidation-reduction process - - - 0.0000000000000000000000000000000000000000000002612 171.0
HKD2_k127_472087_4 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.000000000000001676 82.0
HKD2_k127_472087_5 Glycine zipper - - - 0.000000000001834 79.0
HKD2_k127_472087_6 - - - - 0.00002712 53.0
HKD2_k127_4725175_0 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004304 309.0
HKD2_k127_4725175_1 - K01992 - - 0.000000000000000000000000000000000000000000000000000004262 198.0
HKD2_k127_4725175_2 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term K00441 - 1.12.98.1 0.000000000000000000000000000000000000000000000003111 187.0
HKD2_k127_4725175_3 transport system involved in gliding motility, auxiliary K01992 - - 0.0000000000000000000000000000000000000000000004791 176.0
HKD2_k127_4727482_0 Possible lysine decarboxylase K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000147 165.0
HKD2_k127_4727482_1 Pfam:DUF385 - - - 0.0000000000000000000000000000000000006601 144.0
HKD2_k127_4727482_2 TfoX N-terminal domain - - - 0.0000000000000000000000000000004249 125.0
HKD2_k127_4751369_0 Hemerythrin HHE cation binding domain K01534 - 3.6.3.3,3.6.3.5 1.006e-238 760.0
HKD2_k127_4751369_1 - - - - 0.00000000000000001069 92.0
HKD2_k127_4751369_2 Protein of unknown function (DUF1059) - - - 0.00000000000000004447 82.0
HKD2_k127_4753423_0 Myo-inositol-1-phosphate synthase, GAPDH domain protein K01858 - 5.5.1.4 1.404e-204 645.0
HKD2_k127_4753423_1 Glycolate oxidase subunit GlcD K00104 - 1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 557.0
HKD2_k127_4753423_2 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000003675 187.0
HKD2_k127_4753423_3 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000000000000000002295 173.0
HKD2_k127_4772648_0 Histidinol dehydrogenase K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006518 378.0
HKD2_k127_4772648_1 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 293.0
HKD2_k127_4772648_2 Carbon-nitrogen hydrolase K03820 - - 0.00000000000000000000000000000000000000000001711 168.0
HKD2_k127_4777991_0 PFAM Cytochrome c - - - 0.000000000000000000000000000003196 127.0
HKD2_k127_4777991_1 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000007768 86.0
HKD2_k127_4777991_2 lipolytic protein G-D-S-L family - - - 0.000000000000002171 89.0
HKD2_k127_4777991_4 - - - - 0.000000000002485 71.0
HKD2_k127_4777991_5 - - - - 0.00001716 49.0
HKD2_k127_4777991_6 SGNH hydrolase-like domain, acetyltransferase AlgX - - - 0.00004878 52.0
HKD2_k127_4787256_0 pyruvate dehydrogenase (acetyl-transferring) activity K00163 - 1.2.4.1 9.964e-195 612.0
HKD2_k127_4793283_0 5TM C-terminal transporter carbon starvation CstA K06200 - - 2.636e-223 707.0
HKD2_k127_4793283_1 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 1.19e-209 664.0
HKD2_k127_4838946_0 PFAM Patatin K07001 - - 0.00000000000000000000001528 104.0
HKD2_k127_4848084_0 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000002652 195.0
HKD2_k127_4848084_1 phosphorelay signal transduction system - - - 0.000000000000000000002044 98.0
HKD2_k127_4848084_2 COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K12276 - - 0.00000000005928 70.0
HKD2_k127_4854325_0 aldo-keto reductase (NADP) activity K05275 - 1.1.1.65 0.00000000000000000000000000000000000000000000000002666 182.0
HKD2_k127_4854325_1 nucleotidase K01082 GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0003824,GO:0004441,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008252,GO:0008441,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009628,GO:0009651,GO:0009987,GO:0016053,GO:0016311,GO:0016312,GO:0016787,GO:0016788,GO:0016791,GO:0019752,GO:0023052,GO:0035556,GO:0042538,GO:0042578,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046030,GO:0046394,GO:0048015,GO:0048017,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052829,GO:0065007,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.7 0.000000000000000000000000000000000000000000000001455 176.0
HKD2_k127_4854325_2 Aldo/keto reductase family - - - 0.0000000000000000000006507 101.0
HKD2_k127_4866011_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001903 502.0
HKD2_k127_4866011_1 Succinyl-CoA synthetase, alpha subunit K02381 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000308 362.0
HKD2_k127_4866011_2 Amino acid kinase family K00926 - 2.7.2.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005051 321.0
HKD2_k127_4866011_3 radical SAM K21312 - 1.17.98.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004459 293.0
HKD2_k127_4866011_4 PFAM DsrE DsrF-like family - - - 0.000000000000000000000000000000000000000001591 161.0
HKD2_k127_4913048_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000006317 96.0
HKD2_k127_4913048_1 PFAM MotA TolQ ExbB proton channel K03562 - - 0.00000000000000006554 87.0
HKD2_k127_493466_0 TupA-like ATPgrasp - - - 0.000000000000000000000000000000000000000000000000000000037 202.0
HKD2_k127_493466_1 Neurotransmitter-gated ion-channel ligand binding domain - - - 0.0000000000000000000000000000000000000000000001595 180.0
HKD2_k127_493466_2 Lipase (class 3) K01046 - 3.1.1.3 0.000000000000000000003101 106.0
HKD2_k127_4945595_0 - - - - 0.00003666 56.0
HKD2_k127_4950058_0 Aminotransferase K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005286 320.0
HKD2_k127_4950058_1 PFAM peptidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002568 265.0
HKD2_k127_4950058_2 endonuclease III K07457 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004951 248.0
HKD2_k127_4950058_3 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000000000009967 95.0
HKD2_k127_4962036_0 PFAM conserved - - - 0.0000000000000000000000000000000000000000000000001283 185.0
HKD2_k127_4962036_1 6-O-methylguanine DNA methyltransferase, DNA binding domain K10778 - 2.1.1.63 0.000000000000000000000000000000002706 133.0
HKD2_k127_4967505_0 UDP-glucose 4-epimerase activity K01784,K17947 - 5.1.3.2,5.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002722 344.0
HKD2_k127_4967505_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000000000000447 228.0
HKD2_k127_4967505_2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 - - 0.000000000000000000000000000000000000000000000000000000000001496 225.0
HKD2_k127_4986055_0 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006489 458.0
HKD2_k127_4986055_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000002469 256.0
HKD2_k127_4986055_2 Peptidylprolyl isomerase K03769,K07533 - 5.2.1.8 0.0000000462 64.0
HKD2_k127_4990500_0 Vitamin K-dependent gamma-carboxylase - - - 0.0007406 50.0
HKD2_k127_4992711_0 - - - - 0.000000000000000000000000000000000000000000000000000000000116 213.0
HKD2_k127_4992711_1 PFAM Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000001094 107.0
HKD2_k127_4992711_2 oligoendopeptidase F - - - 0.0000000000001134 79.0
HKD2_k127_499727_0 Periplasmic binding protein K07121 - - 0.0000000000000000000008301 108.0
HKD2_k127_5018639_0 NUDIX domain - - - 0.0000000000000000000000000000000000000000000006722 172.0
HKD2_k127_5018639_1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.00000000000000003173 86.0
HKD2_k127_501936_0 oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002062 251.0
HKD2_k127_501936_1 - - - - 0.00000000000000000000000000000000000000000000000000001366 192.0
HKD2_k127_5058349_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005338 389.0
HKD2_k127_5058349_1 Fibronectin type 3 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001919 265.0
HKD2_k127_5058349_2 glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.000000002192 58.0
HKD2_k127_5076394_0 Aspartyl Asparaginyl beta-hydroxylase K00476,K12979 - 1.14.11.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 303.0
HKD2_k127_5076394_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K07027 - - 0.00000000000000001446 95.0
HKD2_k127_5077511_0 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 299.0
HKD2_k127_5077511_1 GIY-YIG type nucleases (URI domain) K07461 - - 0.000000000000162 71.0
HKD2_k127_5077511_2 GIY-YIG catalytic domain K07461 - - 0.000002178 49.0
HKD2_k127_5100218_0 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002021 248.0
HKD2_k127_5100218_1 Hit family K19710 - 2.7.7.53 0.00000000000000000000000000000000000000000000000000000000000007523 216.0
HKD2_k127_5100218_2 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.0000000000000000000000000000000000000002776 156.0
HKD2_k127_516328_0 - - - - 0.00000000000000000000000000000000000006192 154.0
HKD2_k127_516328_1 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000004398 111.0
HKD2_k127_5182767_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000319 366.0
HKD2_k127_5182767_1 DHH family K07462 - - 0.00000000000000000000000000000000000000000000000193 179.0
HKD2_k127_519762_0 enzyme related to lactoylglutathione lyase K06996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002258 263.0
HKD2_k127_519762_1 PFAM Prenyltransferase squalene oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009345 258.0
HKD2_k127_519762_2 Cold-Shock Protein K03704 - - 0.0000000000000000000000005766 105.0
HKD2_k127_519762_3 Aminotransferase class-V - - - 0.0001282 46.0
HKD2_k127_5197880_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 450.0
HKD2_k127_5197880_1 ADP-glyceromanno-heptose 6-epimerase activity K00091 - 1.1.1.219 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003241 287.0
HKD2_k127_5245121_0 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 520.0
HKD2_k127_5245121_1 Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) K15256 - - 0.0000000000000000000000000000004743 126.0
HKD2_k127_5249256_0 PFAM Carbamoyl-phosphate synthase L chain K01955 GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 336.0
HKD2_k127_5249256_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000006355 132.0
HKD2_k127_5249256_2 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03591,K03749 - - 0.0000000005351 68.0
HKD2_k127_5276138_0 3-demethylubiquinone-9 3-methyltransferase K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000267 228.0
HKD2_k127_5276138_1 FAD binding domain - - - 0.000000000000000000000000001445 125.0
HKD2_k127_5276138_2 Belongs to the UPF0312 family - - - 0.0000000001486 69.0
HKD2_k127_5282385_0 lysozyme activity K07273 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009345 244.0
HKD2_k127_5282385_1 - - - - 0.0000000000000000000007113 106.0
HKD2_k127_5292687_0 Major facilitator Superfamily K03762,K12226 - - 0.000000000000000000000000000000000000005586 154.0
HKD2_k127_5292687_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000208 117.0
HKD2_k127_5292687_2 SprT-like family - - - 0.000000000005479 70.0
HKD2_k127_5295051_0 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002658 269.0
HKD2_k127_5328623_0 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008752 411.0
HKD2_k127_5328623_1 Methylase involved in ubiquinone menaquinone K07755 - 2.1.1.137 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000709 407.0
HKD2_k127_5328623_2 mannose-1-phosphate guanylyltransferase K00971 - 2.7.7.13 0.000000000000000000000000000000000000000000000000005203 186.0
HKD2_k127_5328623_3 peroxiredoxin activity K00627,K01607 - 2.3.1.12,4.1.1.44 0.0000000000000000000000000000000000000000000000003062 177.0
HKD2_k127_5328623_4 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000006523 177.0
HKD2_k127_5331796_0 to GB M29450 SP P16497 GB M31067 PID 143333 PID 143631 percent identity - - - 0.00000000000000000000006531 114.0
HKD2_k127_5343533_0 TIGRFAM peptidase T-like protein K01258 - 3.4.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002817 340.0
HKD2_k127_5343533_1 NUDIX domain K00077,K01092,K03574,K03795 - 1.1.1.169,3.1.3.25,3.6.1.55,4.99.1.3 0.00000000000000000000000000000002136 130.0
HKD2_k127_5343533_2 Transcriptional regulator ArsR family - - - 0.00000000000002125 79.0
HKD2_k127_5349120_0 Belongs to the peptidase S16 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 567.0
HKD2_k127_5349120_1 Protein tyrosine kinase - - - 0.0000000000000000000001072 102.0
HKD2_k127_5361062_0 Tricorn protease homolog K08676 - - 4.069e-269 852.0
HKD2_k127_5361062_1 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000001528 237.0
HKD2_k127_5361062_2 peroxiredoxin activity K01607 - 4.1.1.44 0.0000000000002957 74.0
HKD2_k127_5363829_0 AsmA-like C-terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001158 286.0
HKD2_k127_5391906_0 ATP synthesis coupled electron transport K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 417.0
HKD2_k127_5391906_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 351.0
HKD2_k127_5391906_2 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000006331 232.0
HKD2_k127_5391906_3 AraC-like ligand binding domain - - - 0.0000000000000000000000000000000000000001378 154.0
HKD2_k127_5400339_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 290.0
HKD2_k127_5400339_1 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000001381 156.0
HKD2_k127_5400734_0 transport, permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004654 325.0
HKD2_k127_5400734_1 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009701 323.0
HKD2_k127_5400734_2 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.000000000000000000000000000000000000000000000002993 179.0
HKD2_k127_5400734_3 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000000000000000000000007392 176.0
HKD2_k127_5400734_4 2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase K01625 - 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000000000000005024 164.0
HKD2_k127_5400734_5 Belongs to the Fur family K09825 GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2000374,GO:2001141 - 0.00000000000000000000000000000000000006023 147.0
HKD2_k127_541365_0 Bacterial DNA polymerase III alpha subunit K02337 - 2.7.7.7 0.0 1073.0
HKD2_k127_541365_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019897,GO:0019898,GO:0031224,GO:0031226,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033036,GO:0033365,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000000000000002106 92.0
HKD2_k127_5440509_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003656 435.0
HKD2_k127_5440509_1 Multicopper oxidase K04753 - - 0.0000000000000000000000000000000000000000000000266 177.0
HKD2_k127_5443115_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000211 212.0
HKD2_k127_5443115_1 SH3 domain (SH3b1 type) - - - 0.000000000000000000000000000000001702 139.0
HKD2_k127_5446668_0 PFAM Vitamin K epoxide reductase family - - - 0.000000000000000000000000000000000000000002151 166.0
HKD2_k127_5446668_1 Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities K01782 GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 0.0000000000000000000002394 98.0
HKD2_k127_545646_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008394 524.0
HKD2_k127_5457226_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002338 503.0
HKD2_k127_5457226_1 TIGRFAM malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004647 352.0
HKD2_k127_5457226_2 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005697 297.0
HKD2_k127_5457226_3 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.0000000000000000000008904 97.0
HKD2_k127_550530_0 Belongs to the phosphoglycerate kinase family K00927,K01803 - 2.7.2.3,5.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003523 283.0
HKD2_k127_550530_1 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000003103 250.0
HKD2_k127_550530_2 Preprotein translocase SecG subunit K03075 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000001392 87.0
HKD2_k127_550530_3 PFAM Aminotransferase class I and II - - - 0.000001104 50.0
HKD2_k127_5527891_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 533.0
HKD2_k127_5527891_1 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009528 315.0
HKD2_k127_5527891_2 electron transfer flavoprotein, alpha subunit K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002026 314.0
HKD2_k127_5527891_3 Carbonic anhydrase K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000001479 188.0
HKD2_k127_5527891_4 Electron transfer flavoprotein subunit beta K03521 - - 0.0000000000000168 76.0
HKD2_k127_5533610_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000002527 239.0
HKD2_k127_5533610_1 intracellular chloride channel activity K05027,K05030 - - 0.00005417 53.0
HKD2_k127_5540540_0 ABC transporter K01990 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000009492 196.0
HKD2_k127_5540540_1 cyclic nucleotide binding K01420,K10716,K10914,K16922 - - 0.000000000000000000000000000000000000000000001257 174.0
HKD2_k127_5540540_2 Protein of unknown function (DUF2892) - - - 0.000000000002569 69.0
HKD2_k127_5548748_0 Surface antigen K07277 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 353.0
HKD2_k127_5550605_0 Polysaccharide biosynthesis/export protein K01991 - - 0.0000000000000000000000000002692 120.0
HKD2_k127_5553000_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 8.938e-274 848.0
HKD2_k127_5559850_0 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 305.0
HKD2_k127_5561439_0 Sigma-70 region 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 484.0
HKD2_k127_5561439_1 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 321.0
HKD2_k127_5561439_2 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000001082 183.0
HKD2_k127_5561439_3 YCII-related domain - - - 0.0000000000000000000000000000000000009994 144.0
HKD2_k127_5561439_4 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000001433 102.0
HKD2_k127_5561439_5 TQO small subunit DoxD K15977 - - 0.000000000000000006154 89.0
HKD2_k127_5563602_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 1.233e-203 652.0
HKD2_k127_5563602_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009567 476.0
HKD2_k127_5563602_2 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 301.0
HKD2_k127_5563602_3 polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000009549 184.0
HKD2_k127_5563602_4 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000003094 182.0
HKD2_k127_5563602_5 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000005182 177.0
HKD2_k127_5565703_0 Probable RNA and SrmB- binding site of polymerase A K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008891 431.0
HKD2_k127_5565703_1 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000002315 85.0
HKD2_k127_5565703_2 - - - - 0.0000005218 58.0
HKD2_k127_5565703_3 AMP-binding enzyme - - - 0.00000911 57.0
HKD2_k127_5584610_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000273 602.0
HKD2_k127_5584610_1 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042,K11528 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 437.0
HKD2_k127_5584610_2 Single-strand binding protein family K03111 - - 0.0000000000000000000000000000000000000000001103 165.0
HKD2_k127_5584610_3 Mannose-6-phosphate isomerase - - - 0.00000000000000000000000000000000000002962 146.0
HKD2_k127_5584610_4 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - 0.00006513 47.0
HKD2_k127_5608933_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 342.0
HKD2_k127_5608933_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000002032 153.0
HKD2_k127_5608933_2 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07712 - - 0.0000003988 56.0
HKD2_k127_5620389_0 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.000000000000000000000000000000000000000000000000000000002512 207.0
HKD2_k127_5620389_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116,K03117 - - 0.000000000003529 68.0
HKD2_k127_5627063_0 Mur ligase, middle domain K11754 - 6.3.2.12,6.3.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002974 284.0
HKD2_k127_5627063_1 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000009043 167.0
HKD2_k127_5627063_2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - 0.00000000000000000000000000000001643 129.0
HKD2_k127_5627063_3 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity - - - 0.00001719 46.0
HKD2_k127_5636706_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005031 431.0
HKD2_k127_5636706_1 thioesterase - - - 0.00000000000000000000000000000000000000000000005587 173.0
HKD2_k127_5636706_2 - - - - 0.000000000000002405 84.0
HKD2_k127_5645697_0 Cytochrome c - - - 0.00000000000000000000000000000000000000000000003089 177.0
HKD2_k127_5645697_1 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.000000000000000000000000008923 121.0
HKD2_k127_5645697_2 PFAM UspA domain protein - - - 0.000000000005754 71.0
HKD2_k127_5645697_3 AMP binding - - - 0.0000897 53.0
HKD2_k127_5719304_0 PFAM cytochrome c biogenesis protein, transmembrane region K06196 - - 0.0000000000000000000000000000000000000000000000000000000009309 209.0
HKD2_k127_5719304_1 Uncharacterized protein conserved in bacteria (DUF2064) K09931,K20742 - 3.4.14.13 0.0000000000000000000000000000000000000000000001616 175.0
HKD2_k127_5719304_2 Thioredoxin-like - - - 0.00000000000000000000000000002382 124.0
HKD2_k127_5719304_3 radical SAM domain protein - - - 0.0000000000000000002184 88.0
HKD2_k127_572201_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0003674,GO:0003824,GO:0016740,GO:0016757 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004145 288.0
HKD2_k127_572201_1 regulation of DNA-templated transcription, elongation - - - 0.0000000000000000000000000000000000000000007381 171.0
HKD2_k127_5724745_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006671 582.0
HKD2_k127_5724745_1 Type II and III secretion system protein K02453 - - 0.000000000000000000000000000000000000001056 154.0
HKD2_k127_5724745_2 General secretion pathway protein F K02455,K02653 - - 0.00000000000000000000000000006646 120.0
HKD2_k127_5727970_0 reductase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - 0.0000000000000000000000000000000000000000000000000000000001519 211.0
HKD2_k127_5727970_1 Cytochrome c mono- and diheme variants - - - 0.000000000000000000000000000000000000000000000000000000323 198.0
HKD2_k127_5727970_2 Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source K00782 - - 0.000000000000000000000000000006182 128.0
HKD2_k127_5727970_3 Domain of unknown function (DUF3390) K18929 - - 0.00000000000002181 77.0
HKD2_k127_5735508_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.000000000000000000000000001436 130.0
HKD2_k127_5739571_0 COG0471 Di- and tricarboxylate transporters K14445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 421.0
HKD2_k127_5739571_1 ribonuclease Rne Rng family K08300,K08301 - 3.1.26.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 421.0
HKD2_k127_5739571_2 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000003315 261.0
HKD2_k127_5739571_3 Lysin motif - - - 0.000000000000000000000000000000000000000000000000000363 197.0
HKD2_k127_5739571_4 PFAM Glyoxalase bleomycin resistance protein dioxygenase K05606 - 5.1.99.1 0.000000000000000000000000000000000000008629 149.0
HKD2_k127_5739571_5 COG3209 Rhs family protein - - - 0.000000000000000001133 96.0
HKD2_k127_5739571_6 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000002633 70.0
HKD2_k127_5739571_7 DNA polymerase Ligase (LigD) - - - 0.000000000001043 74.0
HKD2_k127_5739571_8 THIoesterase K18700 - 3.1.2.29 0.000000000008598 71.0
HKD2_k127_5761312_0 PFAM Peptidase family S58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 294.0
HKD2_k127_5761312_1 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000733 290.0
HKD2_k127_5770923_0 COG4206 Outer membrane cobalamin receptor protein K02014,K16092 - - 0.00000000000000000000000000000000000000000000000000000000001328 224.0
HKD2_k127_5777284_0 integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000000000382 216.0
HKD2_k127_5782607_0 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000000000000000005654 138.0
HKD2_k127_5782607_1 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63 0.0000000000000000000000000000000003818 138.0
HKD2_k127_5782607_2 GIY-YIG catalytic domain - - - 0.0000000000000000000000001018 107.0
HKD2_k127_5782607_3 endonuclease containing a URI domain K07461 - - 0.0000001912 53.0
HKD2_k127_5793965_0 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.0000000000000000134 84.0
HKD2_k127_5793965_1 AsmA-like C-terminal region - - - 0.00000000000001002 84.0
HKD2_k127_5794812_0 PFAM Aldo keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003063 291.0
HKD2_k127_5794812_1 F420H(2)-dependent quinone reductase - - - 0.0000000000000000001556 93.0
HKD2_k127_5801991_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007652 464.0
HKD2_k127_5805025_0 4Fe-4S binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 421.0
HKD2_k127_5805025_1 Pfam SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000003315 220.0
HKD2_k127_5805025_2 glucan 1,4-alpha-glucosidase activity K05989,K20541 - 3.2.1.40 0.0000000000000000000000000000000000000003525 153.0
HKD2_k127_580864_0 Acyl-CoA dehydrogenase, N-terminal domain K00248 - 1.3.8.1 0.000000000000000002371 86.0
HKD2_k127_580864_1 Dodecin - - - 0.000000000000004616 76.0
HKD2_k127_5810004_0 ThiJ PfpI - - - 0.00000000000000000000000008817 109.0
HKD2_k127_5810004_1 - - - - 0.00000000000000003368 89.0
HKD2_k127_5810004_2 - - - - 0.00000002259 64.0
HKD2_k127_5828130_0 Putative methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000001306 210.0
HKD2_k127_5828130_1 Cysteine synthase K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000003746 164.0
HKD2_k127_5828130_2 PFAM Aminotransferase class I and II K00812,K10907 - 2.6.1.1 0.00000000000000000000000000000000005606 150.0
HKD2_k127_5828130_3 Succinyl-CoA synthetase, alpha subunit K02381 - - 0.000001406 57.0
HKD2_k127_5828130_4 CoA-ligase K02381 - - 0.0002483 50.0
HKD2_k127_583730_0 Cytochrome c - - - 0.0000000000000000000000000000000000000003005 170.0
HKD2_k127_583730_1 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000009584 138.0
HKD2_k127_5860370_0 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003817 509.0
HKD2_k127_5860370_1 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006634 274.0
HKD2_k127_5860370_2 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000002495 217.0
HKD2_k127_5860370_3 Belongs to the sigma-70 factor family. ECF subfamily K03088 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.00000000000000000000000000002747 123.0
HKD2_k127_5870044_0 PFAM Mannosyl oligosaccharide glucosidase - - - 0.0 1416.0
HKD2_k127_5870044_1 glycogen debranching - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007089 282.0
HKD2_k127_5870044_2 Protein of unknown function (DUF2934) - - - 0.000686 44.0
HKD2_k127_5876476_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 586.0
HKD2_k127_5876476_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000008164 260.0
HKD2_k127_5897788_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 423.0
HKD2_k127_5897788_1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway K00927 GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3 0.000000000000000000000006174 104.0
HKD2_k127_5915511_0 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 440.0
HKD2_k127_5915511_1 PFAM Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000002321 231.0
HKD2_k127_5915511_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0017076,GO:0030234,GO:0030554,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - 0.0000000000000000000000000000000002506 140.0
HKD2_k127_5935099_0 Pyridoxal-dependent decarboxylase, C-terminal sheet domain K13747 - 4.1.1.96 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 472.0
HKD2_k127_5943738_0 Belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000005403 232.0
HKD2_k127_5943738_1 Autotransporter beta-domain - - - 0.0000000000000000000000000000003688 138.0
HKD2_k127_5943738_2 Autotransporter beta-domain - - - 0.0003912 43.0
HKD2_k127_5945014_0 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 6.011e-228 711.0
HKD2_k127_5945014_1 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.263e-219 694.0
HKD2_k127_5945014_2 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 584.0
HKD2_k127_5945014_3 methyltransferase K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000002775 249.0
HKD2_k127_5945014_4 B12 binding domain K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000003051 182.0
HKD2_k127_5945014_5 Helix-hairpin-helix domain - - - 0.000000000000000000000000002549 113.0
HKD2_k127_59465_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008565 539.0
HKD2_k127_59465_1 NAD(P)H binding domain of trans-2-enoyl-CoA reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000595 338.0
HKD2_k127_5956285_0 COG0714 MoxR-like ATPases K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008913 402.0
HKD2_k127_5956285_1 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002098 261.0
HKD2_k127_5956285_2 Domain of unknown function (DUF4381) - - - 0.00000000000000000000000003634 112.0
HKD2_k127_5977713_0 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000000000001285 139.0
HKD2_k127_5981213_0 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K10778 - 2.1.1.63 0.00000000000000000000000000000000000000000000000000000000000000000001912 235.0
HKD2_k127_5981213_1 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.0000000000000000000000000000000000000000000000000000000000000001973 237.0
HKD2_k127_5981213_2 HNH endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000007941 226.0
HKD2_k127_5981213_3 - - - - 0.00000000000000000000000000000000000000000000002014 177.0
HKD2_k127_5981213_4 lipoprotein biosynthetic process K13292 - - 0.00000000000000000000000000000000000000000008813 169.0
HKD2_k127_5981213_5 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000000000004254 123.0
HKD2_k127_5987314_0 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00033,K00616,K01810,K08300,K13810 - 1.1.1.343,1.1.1.44,2.2.1.2,3.1.26.12,5.3.1.9 3.386e-289 909.0
HKD2_k127_5987314_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000002315 216.0
HKD2_k127_6012676_0 PFAM fumarate lyase K01755 GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007398 533.0
HKD2_k127_6012676_1 Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009109 415.0
HKD2_k127_6012676_2 pyridoxamine 5-phosphate K07005 - - 0.000000000000000000000000000000000000000000000000003665 185.0
HKD2_k127_6022771_0 Riboflavin synthase K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000007168 195.0
HKD2_k127_6022771_1 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 0.00000000000000000000000000000000000000000000121 171.0
HKD2_k127_6023140_0 phosphorelay signal transduction system K11384 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 418.0
HKD2_k127_6023140_1 Cytochrome c554 and c-prime - - - 0.000000000000000000000000000000000000000000000000000000000002746 216.0
HKD2_k127_605368_0 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002748 286.0
HKD2_k127_605368_1 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000002822 134.0
HKD2_k127_605368_2 Ribosomal RNA adenine dimethylase - - - 0.000000000002034 71.0
HKD2_k127_6091687_0 Zinc-uptake complex component A periplasmic K09815 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 295.0
HKD2_k127_6091687_1 dehydrogenase complex catalyzes the overall conversion of - - - 0.00000000000000000000000000000000000000000000000000000004462 201.0
HKD2_k127_6091687_2 PFAM ABC transporter K09817 - - 0.000000000000000000000000000000000000000000000000004246 191.0
HKD2_k127_6091687_3 ABC 3 transport family K09816 - - 0.0000000000000000000000000000000000000000000000001029 188.0
HKD2_k127_6091687_4 tetraacyldisaccharide 4'-kinase activity K09791 - - 0.00000000000000000000000007778 111.0
HKD2_k127_6091687_5 Tfp pilus assembly protein FimV - - - 0.000000000000000000000005796 108.0
HKD2_k127_6091687_6 Staphylococcal nuclease homologues K01174 - 3.1.31.1 0.00000007087 61.0
HKD2_k127_6106380_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 8.806e-249 783.0
HKD2_k127_6106380_1 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000121 621.0
HKD2_k127_6106380_2 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.00000000000000004445 83.0
HKD2_k127_6106740_0 TIGRFAM glutamine synthetase, type I K01915 - 6.3.1.2 3.212e-238 744.0
HKD2_k127_6106740_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.000000000000000000000000000000000000000000000000000000000001412 220.0
HKD2_k127_6106740_2 Belongs to the P(II) protein family K04751 - - 0.0000000000000000000000000000000000000000000000000000002629 195.0
HKD2_k127_6106740_3 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.0000000000000000000000000000000000000000000000000000004351 195.0
HKD2_k127_6106740_4 GGDEF domain K02657 - - 0.00000000000000000000000000001091 134.0
HKD2_k127_6106740_5 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02652 - - 0.000000000000000000000001791 118.0
HKD2_k127_6106740_6 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.00000000000000000008532 93.0
HKD2_k127_6124116_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 6.493e-236 736.0
HKD2_k127_6124116_1 Enoyl-CoA hydratase K01715 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 331.0
HKD2_k127_6124116_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000003019 244.0
HKD2_k127_6124116_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000157 85.0
HKD2_k127_6132310_0 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009058 534.0
HKD2_k127_6132310_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000006951 56.0
HKD2_k127_6147057_0 LAO AO transport system ATPase K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000001426 243.0
HKD2_k127_6147057_1 EVE domain - - - 0.000000000000000000000000000000000000000000000000006016 184.0
HKD2_k127_6162291_0 ferroxidase activity K03594 GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001712 261.0
HKD2_k127_6168297_0 Bacterial regulatory protein, Fis family K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 425.0
HKD2_k127_6168297_1 histidine kinase, HAMP - - - 0.000000000000000000000000000000000000000000000000000001595 199.0
HKD2_k127_6168297_2 3-demethylubiquinone-9 3-methyltransferase - - - 0.000003965 49.0
HKD2_k127_6177_0 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004384 459.0
HKD2_k127_6177_1 PFAM Polysaccharide export protein K01991 - - 0.000000000000000000000001447 107.0
HKD2_k127_6177_2 O-Antigen ligase K02847 - - 0.0000000000000000000002712 107.0
HKD2_k127_6177_3 Type IV pilus biogenesis stability protein PilW - - - 0.00000007053 64.0
HKD2_k127_6181494_0 GtrA-like protein K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000001308 228.0
HKD2_k127_6181494_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000003336 81.0
HKD2_k127_6213340_0 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000004864 202.0
HKD2_k127_6218375_0 Belongs to the UPF0176 family K07146 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002568 280.0
HKD2_k127_6218375_1 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 0.0000000000000000000000000000000000000000000000000000000000003641 215.0
HKD2_k127_6235522_0 ATP-dependent DNA helicase K03657 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002689 625.0
HKD2_k127_6235522_1 Uncharacterized ACR, YdiU/UPF0061 family K08997 - - 0.0000000000000000000000000003386 116.0
HKD2_k127_6238256_0 dicarboxylic acid transport K03309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006428 383.0
HKD2_k127_6238256_1 Putative neutral zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000172 277.0
HKD2_k127_6238256_2 PFAM Bacterial protein of - - - 0.000000000000000000000000000000000000000000000000000003096 197.0
HKD2_k127_6238256_3 SnoaL-like domain - - - 0.00000000000000000000000000000000001802 138.0
HKD2_k127_6238256_4 Protein of unknown function (DUF3568) - - - 0.00000000000000000000000003822 113.0
HKD2_k127_6238256_5 ATP-binding - - - 0.00000000002077 66.0
HKD2_k127_6238256_6 neutral zinc metallopeptidase K07054 - - 0.00000000005293 64.0
HKD2_k127_6238256_7 Diphthamide synthase - - - 0.000001289 52.0
HKD2_k127_6238256_9 metalloprotease K07054 - - 0.00005684 46.0
HKD2_k127_6239513_0 C-terminal four TMM region of protein-O-mannosyltransferase K00728 - 2.4.1.109 0.00000000000000000000000000000000000000000000000000000000000000000000000001151 267.0
HKD2_k127_6239513_1 Pfam:DUF2029 K00728 - 2.4.1.109 0.00000000000000002696 93.0
HKD2_k127_6239513_2 GtrA-like protein - - - 0.00000000000000632 83.0
HKD2_k127_6249674_0 PFAM Methyltransferase K00598 - 2.1.1.144 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001436 276.0
HKD2_k127_6249674_1 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000000004406 132.0
HKD2_k127_6249674_2 Uncharacterized ACR, COG1993 K09137 - - 0.00000000000000000006358 90.0
HKD2_k127_6258625_0 glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005863 320.0
HKD2_k127_6315692_0 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.0000000000000000000000123 106.0
HKD2_k127_6315692_1 - - - - 0.000000000007444 70.0
HKD2_k127_6315692_2 PFAM Cytochrome C assembly protein K02198 - - 0.00007403 48.0
HKD2_k127_6319939_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1140.0
HKD2_k127_6319939_1 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000005764 197.0
HKD2_k127_6319939_2 M42 glutamyl aminopeptidase - - - 0.0000000000000000000000000000000000000000000000004757 179.0
HKD2_k127_6323809_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 1.552e-201 636.0
HKD2_k127_6323809_1 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000007606 115.0
HKD2_k127_6331980_0 glycosyl transferase family - - - 0.0000000000000000000000000000000001677 151.0
HKD2_k127_6331980_1 Glycosyl transferases group 1 - - - 0.00000000000000000001742 106.0
HKD2_k127_6331980_2 Glycosyl transferases group 1 - - - 0.00000001986 64.0
HKD2_k127_6331980_3 - - - - 0.0000003254 62.0
HKD2_k127_6353686_0 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 3.146e-203 646.0
HKD2_k127_6353686_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002476 597.0
HKD2_k127_6365314_0 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000004428 255.0
HKD2_k127_6365314_1 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000000000001699 211.0
HKD2_k127_6365314_2 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000004187 177.0
HKD2_k127_6365314_3 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000001271 176.0
HKD2_k127_6365314_4 YGGT family K02221 - - 0.000000000000000000000000000001561 123.0
HKD2_k127_6365314_5 Las17-binding protein actin regulator - - - 0.00000000000000000000000000001505 120.0
HKD2_k127_6365314_6 Belongs to the UPF0235 family K09131 - - 0.00000001415 57.0
HKD2_k127_636774_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.678e-199 633.0
HKD2_k127_636774_1 Catalyzes the synthesis of GMP from XMP K01951 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 0.0000000000000000000005607 96.0
HKD2_k127_6380673_0 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000005475 237.0
HKD2_k127_6380673_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.000000000000000000000000000000000000000000000000000000000001285 213.0
HKD2_k127_6380673_2 - - - - 0.00000000000000001817 90.0
HKD2_k127_6380873_0 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 426.0
HKD2_k127_6380873_1 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03644,K03801 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181,2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000004371 226.0
HKD2_k127_6380873_2 COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - 0.000000005963 58.0
HKD2_k127_6387120_0 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000002619 119.0
HKD2_k127_6405667_0 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.0 1021.0
HKD2_k127_6413092_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K01147,K12573 - 3.1.13.1 4.979e-198 624.0
HKD2_k127_6413092_1 TIGRFAM methyltransferase FkbM - - - 0.0000000001253 68.0
HKD2_k127_6414459_0 Domain of unknown function DUF87 K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004385 302.0
HKD2_k127_6414459_1 Domain of unknown function DUF87 K06915 - - 0.00000000000000000000000000000000000000000000000000000000000000000002733 237.0
HKD2_k127_6414459_2 Bacterial transferase hexapeptide - - - 0.000000000000000000000000000000000000000000000000000000000002185 211.0
HKD2_k127_6414515_0 Mycoplasma protein of unknown function, DUF285 K21449 - - 0.00009022 54.0
HKD2_k127_6420274_0 aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000001908 237.0
HKD2_k127_6420274_1 PAP2 superfamily - - - 0.00000000000000000000000000000000004559 136.0
HKD2_k127_6420274_2 Thaumatin family - - - 0.00000000001794 77.0
HKD2_k127_6429292_0 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 392.0
HKD2_k127_6429292_1 Belongs to the enoyl-CoA hydratase isomerase family K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002588 372.0
HKD2_k127_6429292_2 Protein conserved in bacteria - - - 0.00000000000000009043 86.0
HKD2_k127_6441002_0 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 615.0
HKD2_k127_6441002_1 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 580.0
HKD2_k127_6441002_2 Sulfotransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001528 272.0
HKD2_k127_6441002_4 Histidine biosynthesis bifunctional protein HisIE K01496,K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000005106 161.0
HKD2_k127_6441002_5 Glycosyl transferase, family 2 K07011 - - 0.0000000000001783 79.0
HKD2_k127_6441002_6 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.000000000003756 71.0
HKD2_k127_6508120_0 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000005954 256.0
HKD2_k127_6508120_1 subunit of a heme lyase K02200 - - 0.0000000000000166 76.0
HKD2_k127_6508999_0 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 372.0
HKD2_k127_6508999_1 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.0000000000000000000000000000000000000000000000000000000001278 217.0
HKD2_k127_6520920_0 Predicted ATPase of the ABC class - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003568 345.0
HKD2_k127_6520920_1 Glycosyl transferase family 11 - - - 0.0000000000000000000000000000000000000000000000000000001155 203.0
HKD2_k127_6520920_2 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000123 120.0
HKD2_k127_6538735_0 40-residue YVTN family beta-propeller - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009878 278.0
HKD2_k127_6538735_1 Serine aminopeptidase, S33 - - - 0.000000000000000000000000001772 119.0
HKD2_k127_6548699_0 Tetratricopeptide repeat K05807 - - 0.0000000000000000000000000000000002367 142.0
HKD2_k127_6548699_1 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000001222 126.0
HKD2_k127_6548699_2 - - - - 0.00001934 53.0
HKD2_k127_6561257_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 379.0
HKD2_k127_6561257_1 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000002095 171.0
HKD2_k127_6574712_0 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 459.0
HKD2_k127_6574712_1 Pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 311.0
HKD2_k127_6574712_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000003418 144.0
HKD2_k127_657603_0 PFAM UBA THIF-type NAD FAD binding K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 338.0
HKD2_k127_657603_1 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000005288 91.0
HKD2_k127_657603_2 Vacuole effluxer Atg22 like K06902 - - 0.0000000005304 61.0
HKD2_k127_6580414_0 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005622 595.0
HKD2_k127_6580414_1 antiporter K07301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005423 345.0
HKD2_k127_6580414_2 HD domain - - - 0.0000000000000000000000000000000000000000000000000006015 188.0
HKD2_k127_6580414_3 LmbE family - - - 0.00000000000000000000000000000000000000000000000002112 187.0
HKD2_k127_6586683_0 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 398.0
HKD2_k127_6586683_1 PFAM 20S proteasome, A and B subunits K07395 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 366.0
HKD2_k127_6586683_2 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008597 265.0
HKD2_k127_6586683_3 Bacterial transglutaminase-like N-terminal region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004179 253.0
HKD2_k127_6586683_4 Circularly permuted ATP-grasp type 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000001682 226.0
HKD2_k127_6586683_5 Protein of unknown function (DUF1326) - - - 0.0000000000000000000000000000000000000000000000000000000000000001176 226.0
HKD2_k127_6586683_6 - - - - 0.0000000001304 72.0
HKD2_k127_6588835_0 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.0000000000000000000000000000000000000000003817 159.0
HKD2_k127_6588835_1 CYTH - - - 0.00000000000000000000000000000000000002928 149.0
HKD2_k127_6588835_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000007297 130.0
HKD2_k127_6593212_0 MarR family - - - 0.0000000000000000000000000000000003259 138.0
HKD2_k127_6593212_1 ISXO2-like transposase domain K07488 - - 0.00000000000000000003622 99.0
HKD2_k127_6593212_2 Beta-lactamase - - - 0.0000000000003333 74.0
HKD2_k127_6606105_0 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 398.0
HKD2_k127_6606105_1 Protein of unknown function (DUF1722) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 361.0
HKD2_k127_6629129_0 PFAM Taurine catabolism dioxygenase TauD TfdA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 336.0
HKD2_k127_6629129_1 ATP-grasp domain - - - 0.00000000000000000000000000000000000008605 147.0
HKD2_k127_6629129_2 Glycosyltransferase sugar-binding region containing DXD motif - - - 0.00000000000000000000000000001129 126.0
HKD2_k127_6629129_3 ATP-grasp domain - - - 0.000000000000000000001467 97.0
HKD2_k127_6629129_4 ATP-grasp domain - - - 0.00003749 48.0
HKD2_k127_6629129_5 ATP-grasp domain - - - 0.0003676 45.0
HKD2_k127_6629396_0 Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 321.0
HKD2_k127_6629396_1 it plays a direct role in the translocation of protons across the membrane K02108 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000000000000000000000000000000000001959 166.0
HKD2_k127_6629396_2 Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter K02116 - - 0.00001542 50.0
HKD2_k127_6635232_0 glucan 1,4-alpha-glucosidase activity K05989,K20541 - 3.2.1.40 0.00000000000000000000000000000000000000004941 159.0
HKD2_k127_6635232_1 Anti-sigma-K factor rskA - - - 0.000000000000000002558 93.0
HKD2_k127_6646061_0 PFAM peptidase M3A and M3B thimet oligopeptidase F K08602 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005327 500.0
HKD2_k127_6646061_1 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008495,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0048033,GO:0048034,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 0.0000000000000000000000000279 113.0
HKD2_k127_6646061_2 COG0656 Aldo keto reductases, related to diketogulonate reductase - - - 0.0000000002886 63.0
HKD2_k127_6650549_0 involved in cell wall biogenesis - - - 0.0000000000002026 73.0
HKD2_k127_6650566_0 YHS domain protein - - - 0.0000000000000003239 83.0
HKD2_k127_6650566_1 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000005593 74.0
HKD2_k127_6650566_2 Putative Fe-S cluster - - - 0.000002335 49.0
HKD2_k127_6664898_0 Serine acetyltransferase, N-terminal K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000375 270.0
HKD2_k127_6664898_1 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000007728 70.0
HKD2_k127_6664898_2 EamA-like transporter family - - - 0.000009455 53.0
HKD2_k127_6672108_0 Catalyzes the oxidation of L-aspartate to iminoaspartate K00278 - 1.4.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001405 460.0
HKD2_k127_6672108_1 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006672 276.0
HKD2_k127_6672108_2 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism K00990 - 2.7.7.59 0.00000000000000000000000000006592 119.0
HKD2_k127_6707738_0 Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000002561 188.0
HKD2_k127_6707738_1 PFAM NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000005908 182.0
HKD2_k127_6710122_0 GTP-binding protein TypA K06207 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004553 416.0
HKD2_k127_6710122_1 COG0500 SAM-dependent methyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001421 246.0
HKD2_k127_6713079_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000002899 238.0
HKD2_k127_6720916_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002088 302.0
HKD2_k127_6739815_0 COG0500 SAM-dependent methyltransferases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 449.0
HKD2_k127_6739815_1 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004818 328.0
HKD2_k127_6739815_2 Redoxin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 284.0
HKD2_k127_6739815_3 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000003142 176.0
HKD2_k127_6739815_4 Protein of unknown function (DUF1579) - - - 0.0000000000000000000000000000000006162 140.0
HKD2_k127_6739815_5 PFAM Iron-binding zinc finger CDGSH type - - - 0.000000000000000000006185 97.0
HKD2_k127_6746462_0 SAM-dependent RNA methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000007167 197.0
HKD2_k127_6746462_1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000000000001375 160.0
HKD2_k127_6746462_2 - - - - 0.000000000007805 76.0
HKD2_k127_6785105_0 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007163 340.0
HKD2_k127_6785105_1 ABC-2 type transporter K09690 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006707 308.0
HKD2_k127_6785105_2 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001724 272.0
HKD2_k127_6785105_3 Appr-1'-p processing enzyme - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000004017 169.0
HKD2_k127_6785105_4 NUDIX domain - - - 0.0000000000000000000002663 101.0
HKD2_k127_6788931_0 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001403 436.0
HKD2_k127_6788931_1 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000802 217.0
HKD2_k127_6792449_0 FAD linked oxidases, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 528.0
HKD2_k127_6792449_1 - - - - 0.0000000000000000000000000001956 127.0
HKD2_k127_6792449_2 Catalyzes the hydrolytic cleavage of a carbon-halogen bond in N-ethylammeline K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000005928 96.0
HKD2_k127_6792449_3 PFAM AIG2 family protein - - - 0.00000002592 65.0
HKD2_k127_6807736_0 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000002597 154.0
HKD2_k127_6807736_1 Penicillin-binding Protein dimerisation domain K05515 - 3.4.16.4 0.00000000000000000002097 96.0
HKD2_k127_6816645_0 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002671 301.0
HKD2_k127_6816645_1 DNA-directed DNA polymerase activity K02340 - 2.7.7.7 0.000000000000000000003885 104.0
HKD2_k127_6816645_2 response to hydrogen peroxide K08985 - - 0.0000000000000001651 82.0
HKD2_k127_6816645_3 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000004035 64.0
HKD2_k127_6825501_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008173 292.0
HKD2_k127_6825501_1 PFAM glycoside hydrolase, family 3 domain protein K01207 - 3.2.1.52 0.0001175 47.0
HKD2_k127_6826847_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 2.964e-253 800.0
HKD2_k127_6826847_1 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000001751 154.0
HKD2_k127_6826847_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000002557 139.0
HKD2_k127_6831095_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 6.168e-251 783.0
HKD2_k127_6831095_1 carboxylase, biotin carboxylase K01961,K01968,K11263 - 6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000363 417.0
HKD2_k127_6831095_2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003178 329.0
HKD2_k127_6831095_3 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001119 321.0
HKD2_k127_6831095_4 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000006026 172.0
HKD2_k127_6832112_0 PFAM Phosphoglycerate mutase K22305 - 3.1.3.3 0.000000000000000000000000000000000000007748 153.0
HKD2_k127_6832112_1 arginyl-tRNA aminoacylation K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000002254 124.0
HKD2_k127_6864538_0 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006525 378.0
HKD2_k127_6909689_0 Cupin 2, conserved barrel domain protein K11477 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005173 326.0
HKD2_k127_6911271_0 PFAM Glycosyl transferases group 1 K13668 GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.346 0.000000000000000000001023 105.0
HKD2_k127_6934718_0 Aminotransferase class-III - - - 1.991e-194 618.0
HKD2_k127_6934718_1 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 443.0
HKD2_k127_6934718_2 AntiSigma factor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002371 255.0
HKD2_k127_6934718_3 Chalcone and stilbene synthases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000002539 249.0
HKD2_k127_6934718_4 DNA-templated transcription, initiation K03088 - - 0.00000000000000000000000000000000000000000000000001713 184.0
HKD2_k127_6934718_5 PFAM blue (type 1) copper domain protein - - - 0.0000000001288 66.0
HKD2_k127_6954895_0 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005189 439.0
HKD2_k127_6954895_1 response regulator K07712 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007438 430.0
HKD2_k127_6954895_2 Thymidylate synthase complementing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 382.0
HKD2_k127_6954895_3 phosphorelay sensor kinase activity K07708,K10942 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000001123 208.0
HKD2_k127_6954895_4 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.00000000000000000000000000000000000000000003267 167.0
HKD2_k127_6954895_5 NAD-dependent protein deacetylase which modulates the activities of several proteins which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription K12410 - - 0.000000000000000000000000000000000000001102 156.0
HKD2_k127_6954895_6 Protein of unknown function (DUF541) K09807 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.00000000000000000000008239 107.0
HKD2_k127_6954895_7 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.0000000000000000000001035 103.0
HKD2_k127_6954895_8 Pentapeptide repeats (9 copies) - - - 0.000000000001504 68.0
HKD2_k127_6954895_9 Trypsin-like peptidase domain - - - 0.00005384 48.0
HKD2_k127_6958459_0 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000002558 145.0
HKD2_k127_696706_0 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005965 406.0
HKD2_k127_696706_1 PFAM Chorismate binding-like K01665 - 2.6.1.85 0.00000000000000000000000000000000000000000000000000000001893 203.0
HKD2_k127_696706_2 Amino-transferase class IV K02619 - 4.1.3.38 0.00000000000000000000000000000000000000000000000001046 190.0
HKD2_k127_696706_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000224 138.0
HKD2_k127_696706_4 transcriptional regulator K16137 - - 0.000000000006256 69.0
HKD2_k127_6976939_0 haloacid dehalogenase K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008856 307.0
HKD2_k127_6976939_1 Inositol monophosphatase K01082,K01092 GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000002881 268.0
HKD2_k127_6976939_2 THIoesterase K18700 - 3.1.2.29 0.00000000000000000000000000000000000000000000000000000003106 199.0
HKD2_k127_6976939_3 ABC transporter, transmembrane K18889 - - 0.00000000000000000000000000001001 121.0
HKD2_k127_6976939_4 PspC domain - - - 0.0000000000000000000758 90.0
HKD2_k127_7006121_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007305 423.0
HKD2_k127_7006121_1 PFAM FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003156 419.0
HKD2_k127_7006121_2 Serine aminopeptidase, S33 K01054 - 3.1.1.23 0.000228 46.0
HKD2_k127_7006121_3 peptidase K06889 - - 0.0009086 50.0
HKD2_k127_7007668_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K00812 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006059 475.0
HKD2_k127_7007668_1 Periplasmic binding protein domain K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000008491 241.0
HKD2_k127_7007668_2 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.0000000000000009893 78.0
HKD2_k127_701830_0 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.000000000000000000000002477 106.0
HKD2_k127_701830_1 Sulfotransferase family - - - 0.000000000000004191 76.0
HKD2_k127_701830_2 Sulfotransferase family - - - 0.00000000000008035 75.0
HKD2_k127_701830_3 Sulfotransferase family - - - 0.000000003675 60.0
HKD2_k127_7022707_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 452.0
HKD2_k127_7022707_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009214 380.0
HKD2_k127_7030713_0 TrkA-N domain K03455,K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 336.0
HKD2_k127_7030713_1 signal-transduction protein containing cAMP-binding and CBS domains K01425 GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 3.5.1.2 0.000000000000000000004889 98.0
HKD2_k127_7030713_2 Universal stress protein - - - 0.00000000002955 71.0
HKD2_k127_7064715_0 Na dependent nucleoside transporter K03317 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 317.0
HKD2_k127_7064715_1 Large family of predicted nucleotide-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007265 278.0
HKD2_k127_7064715_2 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.0000000000000000000000000000000000000000000000969 176.0
HKD2_k127_708132_0 trisaccharide binding - - - 0.000000006321 63.0
HKD2_k127_708132_1 TonB dependent receptor K16092 - - 0.00000000788 59.0
HKD2_k127_7088863_0 Domains REC, sigma54 interaction, HTH8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004358 424.0
HKD2_k127_7088863_1 Histidine kinase K02482,K18143 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000203 198.0
HKD2_k127_7092374_0 domain, Protein - - - 0.000001371 60.0
HKD2_k127_7092374_1 guanyl-nucleotide exchange factor activity K05349,K13735,K18491,K20276 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 3.2.1.21 0.0001724 51.0
HKD2_k127_7093339_0 Phenazine biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 351.0
HKD2_k127_7093339_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004628 304.0
HKD2_k127_7093339_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006541 302.0
HKD2_k127_7093339_3 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine K01579 - 4.1.1.11 0.00000000000000000000000000000000000006367 146.0
HKD2_k127_7096917_0 glutamate synthase K00284 - 1.4.7.1 1.974e-241 757.0
HKD2_k127_7096917_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001077 289.0
HKD2_k127_7120848_0 Tetratricopeptide TPR_2 repeat protein - - - 0.00000000000000000000000000001218 136.0
HKD2_k127_7120848_1 Tetratricopeptide repeat - - - 0.00000000000000001667 90.0
HKD2_k127_7125486_0 Belongs to the argininosuccinate synthase family. Type 1 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 461.0
HKD2_k127_7125486_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009009 306.0
HKD2_k127_7125486_2 Multi-copper polyphenol oxidoreductase laccase K05810 - - 0.000000000000000000000000000000000000001634 155.0
HKD2_k127_7139230_0 AAA domain K07028 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004326 419.0
HKD2_k127_7139230_1 Universal stress protein - - - 0.00000000000468 70.0
HKD2_k127_714342_0 Phosphoadenosine phosphosulfate reductase family K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006223 331.0
HKD2_k127_714342_1 Sigma-54 interaction domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 321.0
HKD2_k127_714342_2 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.00000000000000000000000000000000000002051 156.0
HKD2_k127_714342_3 Phosphate transporter family K16331 - - 0.000000000000000000000000006687 116.0
HKD2_k127_714342_4 phosphate transporter K16331 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000003872 105.0
HKD2_k127_714342_5 - - - - 0.0000000000000000000009754 100.0
HKD2_k127_7168588_0 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002119 270.0
HKD2_k127_7168588_1 epimerase K07071 - - 0.0000000000000000000000000000000000000000000000000000000000000004228 224.0
HKD2_k127_7168588_2 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000009627 188.0
HKD2_k127_7168588_3 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000007293 152.0
HKD2_k127_7187698_0 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009045 414.0
HKD2_k127_7187698_1 Thiol oxidoreductase - - - 0.0000000000000000000000000000000000001625 142.0
HKD2_k127_7187698_2 Thiol oxidoreductase - - - 0.00000000000000000000000000000000228 134.0
HKD2_k127_7187698_3 Di-haem oxidoreductase, putative peroxidase - - - 0.00000000000000000000001278 106.0
HKD2_k127_7187698_4 Di-haem oxidoreductase, putative peroxidase - - - 0.000000006279 59.0
HKD2_k127_7250095_0 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007006 382.0
HKD2_k127_7250095_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K19707 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004612 318.0
HKD2_k127_7250095_2 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 309.0
HKD2_k127_7250095_3 Alginate export K16081 - - 0.000000000000000000000000000000000000000000000002819 190.0
HKD2_k127_7250095_4 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000003391 103.0
HKD2_k127_7250095_5 hydrolase activity, acting on ester bonds - - - 0.00000000002089 68.0
HKD2_k127_7254042_0 Mechanosensitive ion channel K22044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001678 301.0
HKD2_k127_7254042_1 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000001806 202.0
HKD2_k127_7254042_2 Metallo-beta-lactamase superfamily - - - 0.0000000000000000000000000000000000000000000000000002446 188.0
HKD2_k127_7254042_3 - - - - 0.000000000000000000000000000000002341 136.0
HKD2_k127_7254042_4 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000008741 117.0
HKD2_k127_7254042_5 - - - - 0.0000000000000008836 79.0
HKD2_k127_7254042_6 MarR family - - - 0.00000000000006134 78.0
HKD2_k127_7254970_0 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000487 559.0
HKD2_k127_7254970_1 penicillin-binding protein K03814 - 2.4.1.129 0.000002702 50.0
HKD2_k127_7259299_0 Aminotransferase K03430 - 2.6.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001266 494.0
HKD2_k127_7259299_1 Yip1 domain - - - 0.0000000000000000000000000000000000000000000000000000000000002203 216.0
HKD2_k127_7259299_2 - - - - 0.000000000000000000000000000000000000000000005162 168.0
HKD2_k127_7259299_3 Protein of unknown function, DUF393 - - - 0.00000000000000000000000000000000000000000026 162.0
HKD2_k127_7259299_4 - - - - 0.00000000000000000000000000000000000001498 150.0
HKD2_k127_7259299_5 membrane - - - 0.000000000000003397 75.0
HKD2_k127_7270539_0 Required for chromosome condensation and partitioning K03529 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002867 445.0
HKD2_k127_7270539_1 DnaJ central domain - - - 0.0000000001734 73.0
HKD2_k127_7276016_0 PFAM Glycosyl K12994 - 2.4.1.349 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 357.0
HKD2_k127_7276016_1 OsmC-like protein - - - 0.0000000000000003578 83.0
HKD2_k127_7277585_0 Thi4 family K03146 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0018131,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0046872,GO:0046914,GO:0052837,GO:0052838,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 365.0
HKD2_k127_7277585_1 Ribosomal protein L9, N-terminal domain K02939 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000008553 141.0
HKD2_k127_7277585_2 rRNA binding K02963 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000001765 88.0
HKD2_k127_7277585_3 - - - - 0.000000000000005662 77.0
HKD2_k127_7277585_4 - - - - 0.00000000000896 76.0
HKD2_k127_7277855_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 6.213e-281 880.0
HKD2_k127_7277855_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 340.0
HKD2_k127_7277855_2 dehydratase K01724 - 4.2.1.96 0.00000000000000000000001383 102.0
HKD2_k127_7277855_3 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000001235 51.0
HKD2_k127_7286967_0 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 516.0
HKD2_k127_7286967_1 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000001626 152.0
HKD2_k127_7295680_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 1.511e-247 782.0
HKD2_k127_7296337_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015318,GO:0015399,GO:0015405,GO:0015415,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0098660,GO:0098661,GO:0099133 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 381.0
HKD2_k127_7296337_1 negative regulation of phosphate transmembrane transport K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0060255,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000000000000000000000005601 206.0
HKD2_k127_7296337_2 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008794,GO:0016491,GO:0030611,GO:0030613,GO:0030614,GO:0042221,GO:0046685,GO:0050896,GO:0055114 1.20.4.1 0.0000000000000000000000000000000000000000000000007833 177.0
HKD2_k127_7296337_3 Shikimate kinase K00851 - 2.7.1.12 0.0000000000000000000000000000000000000000001477 164.0
HKD2_k127_7320095_0 Short-chain dehydrogenase reductase sdr K00034 - 1.1.1.47 0.00000000000000000000000000000000000000000000000000000000006726 213.0
HKD2_k127_7320095_1 Major facilitator superfamily - - - 0.0000000000000000000000000000000001252 138.0
HKD2_k127_7320095_2 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000002334 136.0
HKD2_k127_7320095_3 Mycolic acid cyclopropane synthetase - - - 0.00002493 50.0
HKD2_k127_7343415_0 Anaphase-promoting complex, cyclosome, subunit 3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002807 265.0
HKD2_k127_7343415_1 PFAM transglutaminase domain protein - - - 0.000000000000000000000000000000000002155 140.0
HKD2_k127_7344837_0 AIR synthase related protein, N-terminal domain K07123 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 297.0
HKD2_k127_7344837_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000005948 123.0
HKD2_k127_7344837_2 Helix-turn-helix domain protein - - - 0.0001944 45.0
HKD2_k127_73620_0 PFAM Repeat of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004245 305.0
HKD2_k127_73620_1 Serine aminopeptidase, S33 K03928 - 3.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000002106 258.0
HKD2_k127_73620_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K20435 - 2.6.1.19 0.00000000000000000003248 90.0
HKD2_k127_7372621_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 3.524e-210 674.0
HKD2_k127_7372621_1 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006634 310.0
HKD2_k127_7372621_2 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00180 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000001648 279.0
HKD2_k127_7372621_3 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.00000000000000000000000000000000000000000000000000000000009065 211.0
HKD2_k127_7372621_4 Carbamoyl-phosphate synthase small chain, CPSase domain K01956 - 6.3.5.5 0.0000000000000000000000000000000000000000000000004899 176.0
HKD2_k127_7372621_5 Protein of unknown function (DUF1272) K09984 - - 0.0000000000000000000000000000000000000000008153 158.0
HKD2_k127_7372621_6 Amidase - - - 0.00000000000000000000000002169 111.0
HKD2_k127_7372621_7 Protein-tyrosine phosphatase K14165 - 3.1.3.16,3.1.3.48 0.00000000000000000000000002586 113.0
HKD2_k127_7372621_8 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.00000000000000000000000009526 110.0
HKD2_k127_7372621_9 - - - - 0.000000000000000006937 85.0
HKD2_k127_737496_0 Protein of unknown function (DUF2892) - - - 0.0000000000000000002418 88.0
HKD2_k127_7375979_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 486.0
HKD2_k127_7375979_1 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002371 264.0
HKD2_k127_7375979_2 TIGRFAM Lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000000000000000006496 214.0
HKD2_k127_7377432_0 Belongs to the precorrin methyltransferase family K13542 - 2.1.1.107,4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001461 533.0
HKD2_k127_7377432_1 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000003642 199.0
HKD2_k127_7377432_2 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.00000000000000000000000003885 112.0
HKD2_k127_740369_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000000000000000000000000009703 145.0
HKD2_k127_7417769_0 HTH-like domain - - - 0.000000000000000000000000000000000000000000000000000004205 194.0
HKD2_k127_7417769_1 Histidine kinase K02482,K03557 - 2.7.13.3 0.0000000000000000000000000000000000000000000000002568 196.0
HKD2_k127_7417769_2 transposase activity K07483,K07497 - - 0.000000000000000000000000000000001371 132.0
HKD2_k127_7417769_3 Histidine kinase K07777,K19661,K21405 - 2.7.13.3 0.0000000000000471 85.0
HKD2_k127_7417769_4 Belongs to the 'phage' integrase family - - - 0.00000004765 57.0
HKD2_k127_7435659_0 MacB-like periplasmic core domain K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009251 548.0
HKD2_k127_7435659_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 291.0
HKD2_k127_7435659_2 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000001345 239.0
HKD2_k127_7435659_3 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000003369 219.0
HKD2_k127_7437209_0 Fatty acid desaturase K00508 - 1.14.19.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000201 259.0
HKD2_k127_7437209_1 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000005893 151.0
HKD2_k127_7441561_0 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.000000000003373 72.0
HKD2_k127_7443119_0 Belongs to the TPP enzyme family K01568 - 4.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 299.0
HKD2_k127_7443119_1 Ecdysteroid kinase - - - 0.000000000000000000000000000000000004468 151.0
HKD2_k127_7450173_0 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 1.221e-236 742.0
HKD2_k127_7450173_1 - - - - 0.000000000000000000000000000004534 124.0
HKD2_k127_7450173_2 Zn-finger in ubiquitin-hydrolases and other protein - - - 0.00000000000667 66.0
HKD2_k127_7450173_3 sodium:proton antiporter activity - - - 0.00000000001576 66.0
HKD2_k127_7511099_0 PFAM luciferase-like - - - 0.00000000000000000000000000000000000000000000000000000000001718 217.0
HKD2_k127_7511099_1 FAD dependent oxidoreductase K00273 - 1.4.3.3 0.00000000000000000000000000000000000000000000000000009204 191.0
HKD2_k127_7511099_2 Protein of unknown function (DUF1460) - - - 0.0000000000000000000000000000000000000000000000004163 179.0
HKD2_k127_7511099_3 PFAM Tetratricopeptide repeat - - - 0.0000000000000000000000000000000003091 141.0
HKD2_k127_7513459_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003025 591.0
HKD2_k127_7513459_1 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097,K22024 - 1.1.1.262,1.1.1.408,1.1.1.409 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009327 302.0
HKD2_k127_7513459_2 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 298.0
HKD2_k127_7513459_3 COG0084 Mg-dependent DNase K03424 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000001369 233.0
HKD2_k127_7513459_4 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000035 195.0
HKD2_k127_7525708_0 4-hydroxyphenylacetate K00483,K14534 - 1.14.14.9,4.2.1.120,5.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001571 545.0
HKD2_k127_7525708_2 Redoxin - - - 0.0000000000000000000000000006318 115.0
HKD2_k127_7525708_3 Redoxin - - - 0.00000000004024 64.0
HKD2_k127_7530977_0 Aminotransferase, class I K14261 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002266 544.0
HKD2_k127_7530977_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001778 341.0
HKD2_k127_7530977_2 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000002165 167.0
HKD2_k127_7530977_3 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000009087 134.0
HKD2_k127_7530977_4 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000000000000001068 136.0
HKD2_k127_7530977_5 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K20810 - 3.5.4.40 0.0000000000000000000000000001889 123.0
HKD2_k127_7537369_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 364.0
HKD2_k127_7537369_1 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001554 297.0
HKD2_k127_7537369_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000002465 170.0
HKD2_k127_7537369_3 COG2931, RTX toxins and related Ca2 -binding proteins K01127 - 3.1.4.50 0.0000000000000008036 89.0
HKD2_k127_7542289_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 2.392e-303 944.0
HKD2_k127_7549501_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 4.302e-243 760.0
HKD2_k127_7549501_1 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000859 313.0
HKD2_k127_7549501_2 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002226 254.0
HKD2_k127_7549501_3 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000001972 218.0
HKD2_k127_7549501_4 Respiratory-chain NADH dehydrogenase, 30 Kd subunit - - - 0.0000000000000000000000000000000000000001644 154.0
HKD2_k127_7549501_5 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.0000000000000000000000000000002745 134.0
HKD2_k127_7549501_6 Major facilitator Superfamily K08151,K08153 - - 0.0004631 45.0
HKD2_k127_7556851_0 UDP-N-acetylmuramate-L-alanine ligase activity K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 529.0
HKD2_k127_7556851_1 Cell wall formation K00075 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000001699 237.0
HKD2_k127_7556851_2 Essential cell division protein K03589 - - 0.00000000007252 72.0
HKD2_k127_7556851_3 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000002518 54.0
HKD2_k127_7567006_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 8.544e-226 709.0
HKD2_k127_7567006_1 Carbon-nitrogen hydrolase K18282 - - 0.00000000000000000000000000000000000000000000000000000000000000000001084 244.0
HKD2_k127_7597920_0 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000000000000000000000000002707 123.0
HKD2_k127_7597920_1 Evidence 4 Homologs of previously reported genes of K15977 - - 0.0000000000000000000000007891 109.0
HKD2_k127_7597920_2 Beta-lactamase class C - - - 0.00000000007549 70.0
HKD2_k127_7634161_0 pyrroloquinoline quinone binding K21430 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 497.0
HKD2_k127_7634161_1 pyrroloquinoline quinone binding K21430 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 472.0
HKD2_k127_7645642_0 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001611 228.0
HKD2_k127_7645642_1 ATPases of PP-loop superfamily - - - 0.0000000000000000000000000000000000000000000001756 171.0
HKD2_k127_7645642_2 acyl-coa hydrolase K01073 - 3.1.2.20 0.00000000000000000000000000000199 126.0
HKD2_k127_7655722_0 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009178 502.0
HKD2_k127_7662734_0 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008837 362.0
HKD2_k127_7662734_1 SMART Elongator protein 3 MiaB NifB K18707 - 2.8.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001451 357.0
HKD2_k127_7662734_2 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.000000001957 68.0
HKD2_k127_7666243_0 Uncharacterised conserved protein (DUF2156) K04567,K14205 - 2.3.2.3,6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002403 389.0
HKD2_k127_7666243_1 Uncharacterised nucleotidyltransferase - - - 0.0000000000000000000000000000007212 132.0
HKD2_k127_7666243_2 Lysylphosphatidylglycerol synthase TM region - - - 0.00000000000000000000000000001213 126.0
HKD2_k127_7666634_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K15778 - 5.4.2.2,5.4.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 452.0
HKD2_k127_7666634_1 Carbon-nitrogen hydrolase K01426 - 3.5.1.4 0.000000146 55.0
HKD2_k127_7675512_0 CoA-binding protein K06929 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000003498 220.0
HKD2_k127_7675512_1 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 0.000000000000000000000000000000000000000000000008424 173.0
HKD2_k127_7675512_2 Cytochrome P450 - - - 0.00000000009135 65.0
HKD2_k127_771202_0 Belongs to the alpha-IPM synthase homocitrate synthase family K01649 - 2.3.3.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 417.0
HKD2_k127_771202_1 PFAM aspartate glutamate uridylate kinase K00928 - 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 357.0
HKD2_k127_7724925_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002133 269.0
HKD2_k127_7724925_1 Biotin-lipoyl like - - - 0.0000000000000000000000000000000000002769 151.0
HKD2_k127_7724925_2 Secretion protein - - - 0.00000000000000396 81.0
HKD2_k127_7724925_3 - - - - 0.0000000001759 63.0
HKD2_k127_7725241_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 419.0
HKD2_k127_7725241_1 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005281 419.0
HKD2_k127_7725241_2 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.00000000000000000000000000000000000000000469 162.0
HKD2_k127_776257_0 Prokaryotic cytochrome b561 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002208 245.0
HKD2_k127_776257_1 Transglutaminase-like superfamily - - - 0.0000001825 62.0
HKD2_k127_7796825_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001958 259.0
HKD2_k127_7796825_1 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.00000000000000000000000000000000000002424 148.0
HKD2_k127_7796825_2 chain release factor K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.000000000000000000000000000000002257 132.0
HKD2_k127_7796825_3 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000799 130.0
HKD2_k127_78219_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 398.0
HKD2_k127_78219_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004524 381.0
HKD2_k127_78219_2 DNA-binding transcription factor activity K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001263 249.0
HKD2_k127_7828182_0 Metallopeptidase family M24 K01262,K01271 - 3.4.11.9,3.4.13.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001714 322.0
HKD2_k127_7828182_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000005031 236.0
HKD2_k127_7828182_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000001159 169.0
HKD2_k127_7828182_3 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000001085 135.0
HKD2_k127_783303_0 PFAM 6-phosphogluconate dehydrogenase NAD-binding K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001751 382.0
HKD2_k127_783303_1 PFAM Glutamine cyclotransferase K00683 - 2.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003348 290.0
HKD2_k127_783303_2 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000008337 236.0
HKD2_k127_783303_3 iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000004763 159.0
HKD2_k127_7840021_0 succinate dehydrogenase K00239 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4 3.932e-274 852.0
HKD2_k127_7840021_1 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001022 526.0
HKD2_k127_7840021_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 432.0
HKD2_k127_7840021_3 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004767 365.0
HKD2_k127_7840021_4 Isocitrate dehydrogenase K00031 - 1.1.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 358.0
HKD2_k127_7840021_5 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 289.0
HKD2_k127_7840021_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03086,K03089 - - 0.000000000000000000000000000000000000000000000000005247 184.0
HKD2_k127_7865361_0 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001407 328.0
HKD2_k127_7865361_1 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.000000000000000000000000000000000000000000000000000009131 192.0
HKD2_k127_7870668_0 Uncharacterized protein family UPF0004 K06168 - 2.8.4.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003151 402.0
HKD2_k127_7870668_1 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000000000000000000002095 174.0
HKD2_k127_787091_0 DNA polymerase K02347 - - 0.00000000000000000000000000002834 119.0
HKD2_k127_787091_1 COG0003 Oxyanion-translocating ATPase K01551 - 3.6.3.16 0.00000000000000000007506 96.0
HKD2_k127_7874103_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1252.0
HKD2_k127_7874103_1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000853 597.0
HKD2_k127_7874103_2 Catalyzes the conversion of dihydroorotate to orotate K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004447 481.0
HKD2_k127_7874103_3 S-acyltransferase activity K00627 GO:0003674,GO:0003824,GO:0004742,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016407,GO:0016417,GO:0016418,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030523,GO:0031405,GO:0031406,GO:0032787,GO:0032991,GO:0033293,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1902494,GO:1990204 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 451.0
HKD2_k127_7874103_4 pyruvate dehydrogenase (acetyl-transferring) activity K00163 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 294.0
HKD2_k127_7874103_5 Histidine kinase-like ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002363 286.0
HKD2_k127_7891977_0 type I phosphodiesterase nucleotide pyrophosphatase - GO:0003674,GO:0003824,GO:0004035,GO:0004346,GO:0005488,GO:0005575,GO:0005623,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008877,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046872,GO:0046914,GO:0050308,GO:0050309,GO:0098519 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002876 519.0
HKD2_k127_7891977_1 Peptidase dimerisation domain K13049 - - 0.00002976 46.0
HKD2_k127_791288_0 Repeat of Unknown Function (DUF347) - - - 0.00001506 49.0
HKD2_k127_7936547_0 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases K00320,K14728 - 1.5.98.2 0.00000000000000000000000000000000000000000000000000000000000000000000002372 254.0
HKD2_k127_7936547_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000004432 197.0
HKD2_k127_7942567_0 alcohol dehydrogenase K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000002184 214.0
HKD2_k127_7942567_1 CHAD domain - - - 0.000000000000000000000000000000000007221 148.0
HKD2_k127_7981578_0 SMART von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000001764 212.0
HKD2_k127_7981578_1 Phage shock protein A, PspA K03969 - - 0.00000000000001329 83.0
HKD2_k127_7996427_0 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 466.0
HKD2_k127_7996427_1 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001955 432.0
HKD2_k127_7996427_2 Competence-damaged protein K03742,K03743 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 3.5.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 314.0
HKD2_k127_7996427_3 Glycoprotease family - - - 0.0000000000000000000000000000000000000000003704 166.0
HKD2_k127_8024068_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006461 272.0
HKD2_k127_8024068_1 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000865 255.0
HKD2_k127_8024068_2 - - - - 0.0000000000005755 71.0
HKD2_k127_8034121_0 PFAM phosphoesterase K01114 - 3.1.4.3 0.0000000000000003253 81.0
HKD2_k127_8034121_1 serine threonine protein kinase - - - 0.000000000001931 74.0
HKD2_k127_8035238_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001845 430.0
HKD2_k127_8035238_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 299.0
HKD2_k127_8045683_0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) K02626 - 4.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000001971 251.0
HKD2_k127_8045683_1 RmuC family K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006697 245.0
HKD2_k127_8045683_2 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.00000000000000000000000000000000000000000000000000000000001325 211.0
HKD2_k127_8063248_0 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000121 239.0
HKD2_k127_8063248_1 PFAM Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.0000000000000000000000000000000001098 141.0
HKD2_k127_8070132_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 3.856e-243 763.0
HKD2_k127_8079559_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001355 271.0
HKD2_k127_8079559_1 MlaD protein K02067 - - 0.000000000000000000000000000000000000000000000000000001363 200.0
HKD2_k127_8079559_2 dehydratase - - - 0.00000000000000000000000000000000000003178 154.0
HKD2_k127_8085594_0 Catalyzes the synthesis of GMP from XMP K01951,K03790 GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.3.1.128,6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 592.0
HKD2_k127_8092046_0 Integral membrane sensor signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000007372 212.0
HKD2_k127_8092046_1 - - - - 0.0000000000000000000000000000000000000000000009672 174.0
HKD2_k127_8106986_0 Nitrite and sulphite reductase 4Fe-4S K00381,K00392 - 1.8.1.2,1.8.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 447.0
HKD2_k127_8113436_0 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006606 412.0
HKD2_k127_8113436_1 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000003522 213.0
HKD2_k127_8113436_2 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000003796 154.0
HKD2_k127_8113436_3 PFAM pyridoxamine 5'-phosphate oxidase-related - - - 0.00000000000000000000891 94.0
HKD2_k127_8113602_0 PFAM luciferase-like - - - 0.00000000000000000000000000000000000000000000000000000000000000001374 234.0
HKD2_k127_8113602_1 Transglycosylase SLT domain K08309 - - 0.00000000000000000000003327 110.0
HKD2_k127_8125373_0 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000003572 186.0
HKD2_k127_8141017_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K21025 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004843 304.0
HKD2_k127_8157688_0 TIGRFAM LPPG domain protein containing protein K11212 - 2.7.8.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 320.0
HKD2_k127_8157688_1 SurA N-terminal domain K03770 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552 5.2.1.8 0.0000000000000000002294 102.0
HKD2_k127_816401_0 DeoC/LacD family aldolase K11645 GO:0003674,GO:0003824,GO:0004332,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016829,GO:0016830,GO:0016832,GO:0042802,GO:0044424,GO:0044444,GO:0044464 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 518.0
HKD2_k127_816401_1 Phosphoglycerate kinase K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003663 341.0
HKD2_k127_8179361_0 PFAM Mannosyl oligosaccharide glucosidase - - - 2.335e-213 668.0
HKD2_k127_8180473_0 Sodium:alanine symporter family K03310 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007892 295.0
HKD2_k127_8180473_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000002765 242.0
HKD2_k127_8187168_0 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.000000000000000000000000000000000000000000000000000000000003605 219.0
HKD2_k127_8187168_1 Phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000638 205.0
HKD2_k127_8187168_2 Protein of unknown function (DUF502) - - - 0.000000000000000000000000000000000000000000002619 171.0
HKD2_k127_8187168_3 bacterial (prokaryotic) histone like domain K04764 - - 0.000000000000000000001171 97.0
HKD2_k127_8195264_0 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000000000000000000000000006863 184.0
HKD2_k127_8195264_1 PFAM 6-pyruvoyl tetrahydropterin synthase and K01737 - 4.1.2.50,4.2.3.12 0.0000000000000000000001166 100.0
HKD2_k127_8195264_2 nuclear chromosome segregation - - - 0.0001375 53.0
HKD2_k127_8195327_0 PFAM SAICAR synthetase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001644 414.0
HKD2_k127_8195327_1 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005194 345.0
HKD2_k127_8195327_2 epimerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002486 277.0
HKD2_k127_8195327_3 ABC transporter K06158 - - 0.0000000000000000000000000000000000000000000000003954 184.0
HKD2_k127_8195913_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 481.0
HKD2_k127_8195913_1 Proton-conducting membrane transporter K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002292 375.0
HKD2_k127_8200347_0 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003531 440.0
HKD2_k127_8200347_1 PFAM Alanine dehydrogenase PNT, C-terminal domain K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 389.0
HKD2_k127_8200347_2 NhaP-type Na H and K H - - - 0.00000000000000000000000000000000000000000000000000000000000000001416 231.0
HKD2_k127_8200347_3 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000000003559 157.0
HKD2_k127_8200347_4 Fe-S metabolism associated domain K02426 - - 0.000000000000000000000000000000000747 134.0
HKD2_k127_8200347_5 PFAM nitrogen-fixing NifU domain protein K04488 - - 0.00000000000000000000000000001861 123.0
HKD2_k127_8200347_6 NAD(P)+ transhydrogenase (AB-specific) activity K00324 - 1.6.1.2 0.00000000000000237 78.0
HKD2_k127_8200347_7 PFAM CBS domain containing protein - - - 0.0000000001763 67.0
HKD2_k127_8200347_8 - - - - 0.0000001051 57.0
HKD2_k127_8216069_0 E1-E2 ATPase K17686 - 3.6.3.54 7.618e-263 829.0
HKD2_k127_8216069_1 Peptidase family M50 K06212,K06402 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000309 459.0
HKD2_k127_8216069_2 Redoxin K11065 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000001281 210.0
HKD2_k127_8216069_3 Cupredoxin-like domain - - - 0.000000000000000000000000000000000002938 141.0
HKD2_k127_8216069_4 Iron-sulfur cluster assembly protein - - - 0.0000000000000000000000000001691 123.0
HKD2_k127_8216069_5 PFAM Cold-shock protein, DNA-binding K03704 - - 0.0000000000000000000000003374 106.0
HKD2_k127_8217122_0 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity K11779,K11780,K11781,K11784,K18285 GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 1.21.98.1,2.5.1.120,2.5.1.77 0.00000000000000000000000000000000000000000000000000000000000000001314 228.0
HKD2_k127_8225617_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000006671 233.0
HKD2_k127_8225617_1 D-ala D-ala ligase N-terminus K01921 - 6.3.2.4 0.0000000000000000000000008518 105.0
HKD2_k127_8227127_0 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009391 386.0
HKD2_k127_8227127_1 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008854 353.0
HKD2_k127_8227127_2 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009665 276.0
HKD2_k127_8227127_3 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000222 271.0
HKD2_k127_8231506_0 PFAM phosphoesterase, RecJ domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002266 281.0
HKD2_k127_8231506_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000007732 52.0
HKD2_k127_8233521_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 1.136e-205 650.0
HKD2_k127_8233521_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000000000000000000000005957 211.0
HKD2_k127_8233521_2 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.00000000000001342 73.0
HKD2_k127_8239086_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000001992 267.0
HKD2_k127_8239086_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000000000000000000000000000000000000000000000008403 237.0
HKD2_k127_8240467_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 565.0
HKD2_k127_8240467_1 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 288.0
HKD2_k127_8240467_2 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.000000000000000000000000000002522 126.0
HKD2_k127_8240467_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000001061 103.0
HKD2_k127_8264533_0 Amino acid permease K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000071 356.0
HKD2_k127_8264533_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000002835 100.0
HKD2_k127_8264533_2 Protein of unknown function (DUF456) K09793 - - 0.000000000000000000001657 100.0
HKD2_k127_8264565_0 Cell shape determining protein MreB Mrl K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 469.0
HKD2_k127_8264565_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000001773 51.0
HKD2_k127_8270613_0 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009078 296.0
HKD2_k127_8270613_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007742 255.0
HKD2_k127_8270613_2 - - - - 0.0000000000000000000001035 103.0
HKD2_k127_8270613_3 Peptidase family M23 - - - 0.000000001281 59.0
HKD2_k127_8272797_0 Protein tyrosine kinase - - - 0.0000000000000000000000000000000000000000000000000000002919 222.0
HKD2_k127_8272797_1 regulation of mitotic metaphase/anaphase transition K03355 GO:0000070,GO:0000151,GO:0000152,GO:0000209,GO:0000278,GO:0000280,GO:0000819,GO:0003002,GO:0003674,GO:0003824,GO:0004842,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005680,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007080,GO:0007088,GO:0007091,GO:0007096,GO:0007113,GO:0007275,GO:0007346,GO:0007389,GO:0008150,GO:0008152,GO:0008356,GO:0009056,GO:0009057,GO:0009798,GO:0009896,GO:0009948,GO:0009949,GO:0009952,GO:0009987,GO:0010498,GO:0010564,GO:0010638,GO:0010965,GO:0016043,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0019941,GO:0022402,GO:0022603,GO:0030071,GO:0030163,GO:0031145,GO:0031331,GO:0031461,GO:0031974,GO:0031981,GO:0032270,GO:0032436,GO:0032446,GO:0032501,GO:0032502,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0036211,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044770,GO:0044772,GO:0044784,GO:0045732,GO:0045787,GO:0045840,GO:0045842,GO:0045862,GO:0045931,GO:0048285,GO:0048518,GO:0048522,GO:0048856,GO:0050000,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051130,GO:0051179,GO:0051234,GO:0051239,GO:0051247,GO:0051276,GO:0051301,GO:0051303,GO:0051310,GO:0051603,GO:0051640,GO:0051641,GO:0051649,GO:0051656,GO:0051726,GO:0051781,GO:0051783,GO:0051785,GO:0051983,GO:0051984,GO:0061630,GO:0061659,GO:0062033,GO:0065001,GO:0065007,GO:0070013,GO:0070647,GO:0070979,GO:0071704,GO:0071840,GO:0090068,GO:0090175,GO:0098813,GO:0140014,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1901800,GO:1901970,GO:1901987,GO:1901989,GO:1901990,GO:1901992,GO:1902099,GO:1902101,GO:1902494,GO:1903047,GO:1903052,GO:1903364,GO:1905330,GO:1905818,GO:1905820,GO:1990234,GO:2000026,GO:2000027,GO:2001252 - 0.000007466 60.0
HKD2_k127_8272797_2 dynactin binding K16531 GO:0000003,GO:0000226,GO:0000242,GO:0000278,GO:0000281,GO:0000910,GO:0001085,GO:0001103,GO:0001654,GO:0001750,GO:0001754,GO:0001764,GO:0001838,GO:0001841,GO:0001843,GO:0001894,GO:0001895,GO:0001917,GO:0001947,GO:0002009,GO:0003006,GO:0003007,GO:0003008,GO:0003013,GO:0003073,GO:0003085,GO:0003143,GO:0003352,GO:0003356,GO:0003674,GO:0003774,GO:0003777,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005813,GO:0005814,GO:0005815,GO:0005829,GO:0005856,GO:0005886,GO:0005929,GO:0006810,GO:0006928,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007098,GO:0007154,GO:0007165,GO:0007166,GO:0007275,GO:0007276,GO:0007281,GO:0007283,GO:0007286,GO:0007368,GO:0007389,GO:0007399,GO:0007417,GO:0007420,GO:0007423,GO:0007507,GO:0007600,GO:0007606,GO:0007608,GO:0007610,GO:0008015,GO:0008064,GO:0008092,GO:0008104,GO:0008134,GO:0008150,GO:0008217,GO:0009605,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009799,GO:0009855,GO:0009887,GO:0009888,GO:0009892,GO:0009987,GO:0009991,GO:0010033,GO:0010468,GO:0010564,GO:0010605,GO:0010629,GO:0010638,GO:0010639,GO:0014020,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016331,GO:0016358,GO:0016462,GO:0016477,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019216,GO:0019221,GO:0019222,GO:0019953,GO:0021537,GO:0021543,GO:0021544,GO:0021591,GO:0021756,GO:0021761,GO:0021766,GO:0021915,GO:0021987,GO:0022008,GO:0022402,GO:0022412,GO:0022414,GO:0022607,GO:0023052,GO:0030030,GO:0030031,GO:0030154,GO:0030182,GO:0030534,GO:0030832,GO:0030833,GO:0030837,GO:0030900,GO:0031023,GO:0031090,GO:0031175,GO:0031253,GO:0031333,GO:0031344,GO:0031346,GO:0031514,GO:0031667,GO:0032095,GO:0032096,GO:0032098,GO:0032099,GO:0032101,GO:0032102,GO:0032104,GO:0032105,GO:0032107,GO:0032108,GO:0032231,GO:0032271,GO:0032272,GO:0032391,GO:0032400,GO:0032401,GO:0032402,GO:0032465,GO:0032501,GO:0032502,GO:0032504,GO:0032507,GO:0032535,GO:0032870,GO:0032879,GO:0032886,GO:0032956,GO:0032970,GO:0032991,GO:0033036,GO:0033043,GO:0033059,GO:0033210,GO:0033365,GO:0034097,GO:0034260,GO:0034451,GO:0034452,GO:0034453,GO:0034454,GO:0034464,GO:0034504,GO:0034613,GO:0035050,GO:0035148,GO:0035176,GO:0035239,GO:0035295,GO:0035845,GO:0035869,GO:0036064,GO:0038108,GO:0040008,GO:0040011,GO:0040012,GO:0040014,GO:0040018,GO:0042221,GO:0042461,GO:0042462,GO:0042592,GO:0042995,GO:0043005,GO:0043009,GO:0043014,GO:0043086,GO:0043087,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043232,GO:0043254,GO:0043473,GO:0044085,GO:0044087,GO:0044089,GO:0044092,GO:0044320,GO:0044321,GO:0044380,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044441,GO:0044444,GO:0044446,GO:0044450,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044782,GO:0045185,GO:0045444,GO:0045494,GO:0045724,GO:0045776,GO:0045927,GO:0046530,GO:0046548,GO:0046907,GO:0048232,GO:0048468,GO:0048487,GO:0048513,GO:0048515,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048562,GO:0048568,GO:0048583,GO:0048585,GO:0048592,GO:0048598,GO:0048609,GO:0048638,GO:0048639,GO:0048646,GO:0048666,GO:0048699,GO:0048729,GO:0048731,GO:0048854,GO:0048856,GO:0048869,GO:0048870,GO:0048871,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050877,GO:0050890,GO:0050893,GO:0050896,GO:0051094,GO:0051128,GO:0051129,GO:0051130,GO:0051179,GO:0051234,GO:0051235,GO:0051239,GO:0051240,GO:0051270,GO:0051301,GO:0051302,GO:0051336,GO:0051346,GO:0051457,GO:0051492,GO:0051493,GO:0051494,GO:0051640,GO:0051641,GO:0051648,GO:0051649,GO:0051650,GO:0051651,GO:0051656,GO:0051674,GO:0051703,GO:0051704,GO:0051705,GO:0051716,GO:0051726,GO:0051875,GO:0051904,GO:0051905,GO:0060170,GO:0060249,GO:0060255,GO:0060271,GO:0060295,GO:0060296,GO:0060322,GO:0060324,GO:0060429,GO:0060491,GO:0060562,GO:0060606,GO:0060612,GO:0060613,GO:0060632,GO:0061371,GO:0061448,GO:0061512,GO:0061640,GO:0065007,GO:0065008,GO:0065009,GO:0070491,GO:0070727,GO:0070887,GO:0070925,GO:0071310,GO:0071345,GO:0071495,GO:0071539,GO:0071840,GO:0071944,GO:0072175,GO:0072359,GO:0072393,GO:0072595,GO:0072698,GO:0080090,GO:0090066,GO:0090596,GO:0097458,GO:0097499,GO:0097730,GO:0097731,GO:0097733,GO:0098588,GO:0098590,GO:0110020,GO:0110053,GO:0120025,GO:0120031,GO:0120032,GO:0120034,GO:0120035,GO:0120036,GO:0120038,GO:1902017,GO:1902019,GO:1902115,GO:1902117,GO:1902855,GO:1902903,GO:1902904,GO:1903047,GO:1903546,GO:1905508,GO:1905515,GO:2000145 - 0.00001296 59.0
HKD2_k127_827467_0 Putative methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 345.0
HKD2_k127_827467_1 Sigma-54 interaction domain K02584 - - 0.0000000000002196 71.0
HKD2_k127_8278514_0 Amino acid permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006531 328.0
HKD2_k127_8283468_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 329.0
HKD2_k127_8283468_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005712 289.0
HKD2_k127_8283468_2 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.000000000000000000000000000000000000000000000000000000008729 200.0
HKD2_k127_8283468_3 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000133 143.0
HKD2_k127_8283468_4 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000006407 107.0
HKD2_k127_8283468_5 Ribosomal L29 protein K02904 - - 0.0000001064 58.0
HKD2_k127_8283468_6 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000002889 53.0
HKD2_k127_8323920_0 Glycogen debranching enzyme - - - 0.0 1084.0
HKD2_k127_8323920_1 - - - - 0.000000000000000000000001423 108.0
HKD2_k127_8344756_0 Tetratricopeptide repeat - - - 0.000000000000000001395 94.0
HKD2_k127_8355034_0 PFAM alpha-2-macroglobulin domain protein K06894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 438.0
HKD2_k127_8359676_0 Pyridoxal-phosphate dependent enzyme K12339,K21148 - 2.5.1.113,2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003172 371.0
HKD2_k127_8359676_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 321.0
HKD2_k127_8359676_2 Belongs to the sulfur carrier protein TusA family K04085 - - 0.000000000000000000004305 94.0
HKD2_k127_8359676_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000000305 89.0
HKD2_k127_8390658_0 CBD_II K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001556 361.0
HKD2_k127_8390658_1 single-stranded-DNA-specific exonuclease RecJ K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 339.0
HKD2_k127_8390658_2 Dehydroquinase class II K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000108 184.0
HKD2_k127_8390658_3 Tetratricopeptide repeat - - - 0.000000000000007198 83.0
HKD2_k127_8404418_0 Fkbm family - - - 0.000000000000000000000000000000000000000000000000000000000000000000002075 242.0
HKD2_k127_8404418_1 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000002498 188.0
HKD2_k127_8404418_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000003912 158.0
HKD2_k127_8404418_3 Integrase core domain K07497 - - 0.0002323 46.0
HKD2_k127_8404759_0 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 4.684e-231 739.0
HKD2_k127_8404759_1 Peptidase family M50 - - - 0.00000000000000000000000000000000000005881 148.0
HKD2_k127_8407447_0 glyoxalase III activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004042 252.0
HKD2_k127_8407447_1 Aldo/keto reductase family - - - 0.0000000000000000000000000000000000000000000000000003518 188.0
HKD2_k127_8407447_2 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000000000000002826 157.0
HKD2_k127_8407447_3 NADH ubiquinone oxidoreductase, 20 - - - 0.000000343 53.0
HKD2_k127_8414120_0 AcrB/AcrD/AcrF family - - - 0.0 1103.0
HKD2_k127_8414120_1 with different specificities (related to short-chain alcohol K00034 - 1.1.1.47 0.0000000000000000000000000009612 115.0
HKD2_k127_8430608_0 DEAD DEAH box helicase K03724 - - 2.356e-236 749.0
HKD2_k127_8430608_1 potassium ion transmembrane transporter activity K03549 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 505.0
HKD2_k127_8430608_2 Bacterial protein of unknown function (DUF853) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 370.0
HKD2_k127_8430608_3 Bacterial protein of unknown function (DUF853) K06915 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003882 259.0
HKD2_k127_8430608_4 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000007226 214.0
HKD2_k127_8430608_5 Redoxin K03564 - 1.11.1.15 0.000000000000000000000000000000000000000009659 159.0
HKD2_k127_8434916_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 488.0
HKD2_k127_8434916_1 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004142 322.0
HKD2_k127_8434916_2 AMP-binding enzyme C-terminal domain K00666,K18687 - 6.2.1.41 0.000000000000000000000002045 110.0
HKD2_k127_8455616_0 Belongs to the FPP GGPP synthase family K00795,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004947 296.0
HKD2_k127_8455616_1 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000007392 258.0
HKD2_k127_8455616_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000000482 84.0
HKD2_k127_8455616_3 exodeoxyribonuclease VII activity K03602 - 3.1.11.6 0.000000000002419 70.0
HKD2_k127_8477006_0 PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000001778 189.0
HKD2_k127_85132_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 6.574e-201 643.0
HKD2_k127_85132_1 Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins K03769,K07533 - 5.2.1.8 0.00000000000000002797 92.0
HKD2_k127_85132_2 peptidyl-prolyl cis-trans isomerase K03771 - 5.2.1.8 0.00001508 51.0
HKD2_k127_8523030_0 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.000000000000000000000000000000000000000000000000000000000000004983 227.0
HKD2_k127_8523030_1 Biotin carboxylase C-terminal domain K01961,K01965 - 6.3.4.14,6.4.1.2,6.4.1.3 0.0000000000000000000000000000000004259 136.0
HKD2_k127_8523030_3 Biotin-lipoyl like K01960,K01965,K01968 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.1,6.4.1.3,6.4.1.4 0.000000000000000000000008718 108.0
HKD2_k127_8523030_4 diguanylate cyclase - - - 0.00000057 53.0
HKD2_k127_852396_0 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003579 415.0
HKD2_k127_852396_1 Zincin-like metallopeptidase - - - 0.000000000000000000000000452 109.0
HKD2_k127_852396_2 protein-disulfide reductase activity - - - 0.0000004364 58.0
HKD2_k127_852809_0 arsenite transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001773 248.0
HKD2_k127_8540135_0 A circularly permuted ATPgrasp - - - 0.00000000000000000000000000000000000000000000000000001141 192.0
HKD2_k127_8540135_1 Lipase (class 3) K01046 - 3.1.1.3 0.00000000000000005079 92.0
HKD2_k127_8541086_0 DisA bacterial checkpoint controller nucleotide-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000001441 228.0
HKD2_k127_8541086_1 Metallophosphoesterase, calcineurin superfamily K07096 - - 0.00000000000000000000000000000000000000000000000000000001544 205.0
HKD2_k127_8541995_0 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001289 277.0
HKD2_k127_8550300_0 Diguanylate cyclase with PAS PAC and GAF sensors - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004218 321.0
HKD2_k127_8550300_1 monooxygenase activity - - - 0.000000000000000000000007798 107.0
HKD2_k127_8551653_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K19548 - 1.1.1.385 0.000000000000000000000000000000000000000000000000000000000000002606 226.0
HKD2_k127_8551653_1 Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell K03608 - - 0.000000000000000000000000277 106.0
HKD2_k127_8551653_2 Belongs to the ParA family K03609 - - 0.000000000000000000000001952 103.0
HKD2_k127_8562636_0 LssY C-terminus - - - 0.0000000000000000000000000000004811 127.0
HKD2_k127_8562636_1 LssY C-terminus - - - 0.000000000000000000000000000002245 126.0
HKD2_k127_8562636_2 LssY C-terminus - - - 0.0007563 48.0
HKD2_k127_8579542_0 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 594.0
HKD2_k127_8579542_1 Glutathione S-transferase, C-terminal domain K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000009429 291.0
HKD2_k127_8579542_2 palmitoyl-(protein) hydrolase activity K06999,K15975 - - 0.00000000000000000000000000000000000000000000000000000000000001004 222.0
HKD2_k127_8579542_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K15975 - - 0.0000000000000000000000000000000000000000000000000000002444 198.0
HKD2_k127_8589616_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000572 251.0
HKD2_k127_8589616_1 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000009958 213.0
HKD2_k127_8589616_2 Involved in the binding of tRNA to the ribosomes K02946 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000005177 164.0
HKD2_k127_8589616_3 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.00000000000000000008997 94.0
HKD2_k127_8589616_4 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000004104 72.0
HKD2_k127_8589616_5 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.00000001487 56.0
HKD2_k127_8599962_0 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) K01214 - 3.2.1.68 1.747e-263 828.0
HKD2_k127_8602948_0 glyoxalase III activity - - - 0.00000000000000000000000002068 113.0
HKD2_k127_8602948_1 Bacterial protein of unknown function (DUF899) - - - 0.00000000000000000000000009126 108.0
HKD2_k127_8602948_2 Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus K07261 - - 0.000000000000000000000004508 110.0
HKD2_k127_8602948_3 DNA-binding transcription factor activity - - - 0.0000000000000000000001149 102.0
HKD2_k127_8603820_0 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000001278 211.0
HKD2_k127_8603820_1 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000003708 117.0
HKD2_k127_8645304_0 MazG nucleotide pyrophosphohydrolase domain K02428,K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66,3.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000001747 241.0
HKD2_k127_8645304_1 phosphoglycerate mutase K15635 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000000000001628 229.0
HKD2_k127_8665650_0 KH domain K03595 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006372 326.0
HKD2_k127_8665650_1 glycosyl transferase family - - - 0.0000000000000000000000000000000000015 150.0
HKD2_k127_8665650_2 glycosyl transferase family - - - 0.0000000000002817 79.0
HKD2_k127_8679153_0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.000000000000000000000000000000000000000000000000000009814 199.0
HKD2_k127_8679153_1 SpoIIAA-like - - - 0.00000000000000000000000000000000000005338 145.0
HKD2_k127_8679153_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000009883 147.0
HKD2_k127_8686657_0 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07305,K12267 - 1.8.4.11,1.8.4.12 0.000000000000000000000000000000000000000000000000008372 185.0
HKD2_k127_8686657_1 Mannose-6-phosphate isomerase K00971,K16011 - 2.7.7.13,5.3.1.8 0.0000000000000000000000000000000000000001654 158.0
HKD2_k127_8686657_2 integral membrane protein - - - 0.00000000000000000000000000002184 125.0
HKD2_k127_8744895_0 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059,K18009 - 1.1.1.100,1.1.1.304,1.1.1.76 0.00000000000000000000000000000000000000000000000004536 187.0
HKD2_k127_8744895_1 It is involved in the biological process described with metabolic process K00876 GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009790,GO:0009792,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0032501,GO:0032502,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0048856,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.48 0.0002458 47.0
HKD2_k127_8752281_0 Cobalt uptake substrate-specific transmembrane region K02007 - - 0.0000000000000000000000000000000000001717 149.0
HKD2_k127_8752281_1 PFAM Cobalt transport protein K02008 - - 0.0000000000000000000000000000000008698 141.0
HKD2_k127_8752281_2 part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006 - - 0.00000000000000000000000000004739 120.0
HKD2_k127_8752281_3 Belongs to the Fur family K03711 - - 0.000000000000000000000176 103.0
HKD2_k127_8752281_4 helicase superfamily c-terminal domain K05592 - 3.6.4.13 0.0000000000000000000001913 99.0
HKD2_k127_8772294_0 Phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01835 - 5.4.2.2 1.263e-268 835.0
HKD2_k127_8772294_1 Phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000002263 253.0
HKD2_k127_8772294_2 PFAM Cache K08738 - - 0.00000000000000000000000000000000000000000000000000000000000000001289 246.0
HKD2_k127_8772294_3 Single Cache domain 2 K07647 - 2.7.13.3 0.00000000000000000000000000000000000000000286 175.0
HKD2_k127_8780068_0 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009194 398.0
HKD2_k127_8780068_1 transmembrane transport K02035,K15580 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006811,GO:0006820,GO:0006857,GO:0006869,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010876,GO:0015711,GO:0015718,GO:0015721,GO:0015833,GO:0015849,GO:0015850,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042939,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003479 389.0
HKD2_k127_8780068_2 4-carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000008014 151.0
HKD2_k127_8780068_3 Antibiotic biosynthesis monooxygenase - GO:0003674,GO:0003824 - 0.000000000000003558 78.0
HKD2_k127_8780530_0 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000002074 80.0
HKD2_k127_8780530_1 Membrane protein involved in the export of O-antigen and teichoic acid - - - 0.00000009407 63.0
HKD2_k127_8784430_0 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase K02395,K19220,K19223 GO:0005575,GO:0005576 - 0.000000000000000000000000000000000002662 147.0
HKD2_k127_8784430_1 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.0000000000000000002 94.0
HKD2_k127_8818523_0 Glycosyl transferases group 1 K20444 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000575 349.0
HKD2_k127_8818523_1 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007531 264.0
HKD2_k127_8818523_2 PFAM Glycosyl transferase, group 1 - - - 0.0000000000000000000000000000000000000000001141 174.0
HKD2_k127_8818523_3 Glycosyltransferase like family 2 K07011 - - 0.000801 49.0
HKD2_k127_8819413_0 GIY-YIG type nucleases (URI domain) K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005705 322.0
HKD2_k127_8819413_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K04750 - - 0.00000000000000000000000000000000000000000000000000000008655 197.0
HKD2_k127_8825940_0 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002284 267.0
HKD2_k127_8825940_1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.00000000000000000000000002855 115.0
HKD2_k127_8825940_2 PFAM Uncharacterised protein family UPF0150 - - - 0.00000000000000000002054 96.0
HKD2_k127_8825940_3 Heavy-metal resistance - - - 0.00003742 53.0
HKD2_k127_8851673_0 PFAM AAA ATPase central domain protein K06027 - 3.6.4.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 325.0
HKD2_k127_8861818_0 Calcineurin-like phosphoesterase superfamily domain K07313 - 3.1.3.16 0.000000000000000000000000000000000000001352 156.0
HKD2_k127_8884657_0 Glutamine amidotransferase class-I K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000137 261.0
HKD2_k127_8884657_1 Belongs to the peptidase S16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004378 244.0
HKD2_k127_8884657_2 membrane - - - 0.0000000000000000000000000000001048 128.0
HKD2_k127_8886938_0 Permease family K06901 GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006863,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015205,GO:0015207,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015851,GO:0015853,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904823 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 485.0
HKD2_k127_8886938_1 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000003078 230.0
HKD2_k127_8886938_2 TIGRFAM N-carbamoylputrescine amidase K01431,K12251 - 3.5.1.53,3.5.1.6 0.000000007952 59.0
HKD2_k127_889075_0 Major facilitator superfamily K08170 - - 0.00000000000000000000000000000000000000000000000000000000000000000000004376 248.0
HKD2_k127_889075_1 - - - - 0.0000004664 58.0
HKD2_k127_8893331_0 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008333 391.0
HKD2_k127_8893331_1 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000002337 111.0
HKD2_k127_8893331_2 Putative zinc-finger - - - 0.00000003653 58.0
HKD2_k127_8905730_0 Sulfatase - - - 0.000000000000000000000000000000000000000000000309 187.0
HKD2_k127_8921507_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004019 593.0
HKD2_k127_8921507_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 552.0
HKD2_k127_8921507_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 298.0
HKD2_k127_8921507_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0006611 48.0
HKD2_k127_8963771_0 chorismate synthase activity K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006907 440.0
HKD2_k127_8963771_1 Aminotransferase class I and II K00639,K21784 - 2.3.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003327 369.0
HKD2_k127_8970379_0 - - - - 0.00000000000000000000000000000000005296 136.0
HKD2_k127_8970379_1 Lecithin:cholesterol acyltransferase - - - 0.0000000000000000000000007824 119.0
HKD2_k127_8970379_2 Protein of unknown function (DUF3574) - - - 0.00000000009707 66.0
HKD2_k127_8970379_3 Metallo-beta-lactamase superfamily - - - 0.000000004378 57.0
HKD2_k127_8970379_4 Protein of unknown function (DUF3574) - - - 0.00002135 48.0
HKD2_k127_8974136_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 471.0
HKD2_k127_8974136_1 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004156 366.0
HKD2_k127_8974136_2 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000008118 168.0
HKD2_k127_8979578_0 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384,K03671 GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 430.0
HKD2_k127_8979578_1 Glycine cleavage T-protein C-terminal barrel domain K00605,K06980 - 2.1.2.10 0.0000000000000000000000000000000000000000000000009129 184.0
HKD2_k127_8979578_2 Glycosyltransferase family 87 - - - 0.000000000000000000000000000000002324 140.0
HKD2_k127_8988768_0 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.000000000000000000000000000000000000000000000000000000003968 208.0
HKD2_k127_8988768_1 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.000000000000000000000000000000000000000000000000001707 188.0
HKD2_k127_8988768_2 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.000000000000000000000000000001645 132.0
HKD2_k127_9012660_0 Glycosyl transferase, family 2 - - - 0.000000000000000000000000000000000000000000000000000000008363 207.0
HKD2_k127_9012660_1 glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000001987 163.0
HKD2_k127_9012660_2 pathogenesis - - - 0.000000000000000000000000000000000009397 156.0
HKD2_k127_9026127_0 GTP-binding protein TypA K06207 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001728 337.0
HKD2_k127_9026127_1 Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - 0.0000000000000000000000000000000000009578 141.0
HKD2_k127_9026127_2 ATPase. Has a role at an early stage in the morphogenesis of the spore coat - - - 0.00000000000002 81.0
HKD2_k127_9027377_0 polyphosphate kinase K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 354.0
HKD2_k127_9027377_1 nUDIX hydrolase K01515,K03574,K19710 - 2.7.7.53,3.6.1.13,3.6.1.55 0.000000000000000000000000000000000000000000000002721 177.0
HKD2_k127_9035574_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 8.742e-237 743.0
HKD2_k127_9035574_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003095 497.0
HKD2_k127_9039524_0 AI-2E family transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 340.0
HKD2_k127_9039524_1 PFAM MotA TolQ ExbB proton channel K03561 - - 0.0000000000000000000000000000453 124.0
HKD2_k127_9039524_2 energy transducer activity K03832 - - 0.0000000000000000000000001657 115.0
HKD2_k127_9039524_3 Biopolymer transport protein ExbD TolR K03559 - - 0.00000000000000000000001333 105.0
HKD2_k127_9039524_4 Transcriptional regulator - - - 0.00000006154 56.0
HKD2_k127_9039524_5 response regulator receiver K02481,K07714,K10943 - - 0.0008481 45.0
HKD2_k127_907498_0 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005039 390.0
HKD2_k127_907498_1 Mut7-C ubiquitin K09122 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007414 268.0
HKD2_k127_907498_2 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000002815 126.0
HKD2_k127_907498_3 PFAM Formylglycine-generating sulfatase enzyme - - - 0.00000000009707 66.0
HKD2_k127_9078108_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 5.436e-230 734.0
HKD2_k127_9078108_1 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 522.0
HKD2_k127_9078108_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000008343 225.0
HKD2_k127_9078108_3 response regulator receiver - - - 0.00000000000000000000000000000001211 136.0
HKD2_k127_9078108_4 helix_turn_helix, Lux Regulon - - - 0.000000000001102 76.0
HKD2_k127_9078108_5 DNA protecting protein DprA K04096 - - 0.0000003194 55.0
HKD2_k127_9079128_1 KR domain K00034 - 1.1.1.47 0.00000000000000000000000000000000000000000000000000002899 196.0
HKD2_k127_9079128_2 Dihydroneopterin aldolase K07589 - 5.1.99.7 0.000000000000000000000000002473 114.0
HKD2_k127_9079128_3 Dehydrogenase K06911 - - 0.000000000666 63.0
HKD2_k127_9109322_0 - - - - 0.000000000002765 75.0
HKD2_k127_9119007_0 PAP2 superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002453 325.0
HKD2_k127_9119007_1 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 0.00000000000000000000000000000000000000000000006295 175.0
HKD2_k127_9119007_2 Phosphatidylethanolamine-binding protein K06910 - - 0.00000000000000000000000000000000000000000001444 166.0
HKD2_k127_9119007_3 Belongs to the bacterial histone-like protein family K05788 - - 0.000000000000000001237 87.0
HKD2_k127_9125699_0 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009193 276.0
HKD2_k127_9125699_1 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.0000000000000000000000000000000001456 137.0
HKD2_k127_9125699_2 Insulinase (Peptidase family M16) K07263 - - 0.000000000001666 68.0
HKD2_k127_9141242_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000007008 166.0
HKD2_k127_9141242_1 Domain of unknown function (DUF4301) - - - 0.0000000000000000000000000000000001729 139.0
HKD2_k127_9175490_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 452.0
HKD2_k127_9175490_1 Catalyzes the conversion of dihydroorotate to orotate K00254,K02823,K17828 GO:0000166,GO:0003674,GO:0003824,GO:0004152,GO:0004158,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0016020,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0032553,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 410.0
HKD2_k127_9175490_2 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 355.0
HKD2_k127_9175490_3 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000001648 127.0
HKD2_k127_9178879_0 ABC-type transport system involved in Fe-S cluster assembly, permease component K09014 - - 6.077e-198 619.0
HKD2_k127_9178879_1 FeS assembly protein SufD K09015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003758 385.0
HKD2_k127_9178879_2 ABC transporter K09013 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 374.0
HKD2_k127_9178879_3 Calcineurin-like phosphoesterase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000745 202.0
HKD2_k127_9178879_4 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000001895 153.0
HKD2_k127_9178879_5 of nitrite reductase and ring-hydroxylating K05710 - - 0.00000000000000000000001911 102.0
HKD2_k127_9198754_0 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000003159 184.0
HKD2_k127_9199077_0 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005373 297.0
HKD2_k127_9199077_1 glutamine synthetase K01915 - 6.3.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001333 279.0
HKD2_k127_9199077_2 glutamine synthetase K01915 - 6.3.1.2 0.000000000000000000000003498 106.0
HKD2_k127_9199077_3 PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) - - - 0.00000000000000000004362 93.0
HKD2_k127_9206750_0 COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 426.0
HKD2_k127_9206750_1 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.00000000000000000000000000000000000000000000000000000000005985 213.0
HKD2_k127_9206750_2 Lecithin:cholesterol acyltransferase - - - 0.0000006437 54.0
HKD2_k127_9226213_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009079 505.0
HKD2_k127_9226213_1 Outer membrane lipoprotein carrier protein LolA K03634 - - 0.0000000000000000000000000000000000000003073 158.0
HKD2_k127_9226213_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000003211 126.0
HKD2_k127_9226213_3 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.000000000000000003174 85.0
HKD2_k127_9237865_0 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 304.0
HKD2_k127_9237865_1 PFAM Carbohydrate-selective porin OprB K07267 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001211 260.0
HKD2_k127_9237865_2 Belongs to the type-B carboxylesterase lipase family K03929 - - 0.0000000000000000000000000000000000000000000000000000000000002516 229.0
HKD2_k127_9244140_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005539 451.0
HKD2_k127_9244140_1 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002513 281.0
HKD2_k127_925039_0 signal-transduction protein containing cAMP-binding and CBS domains K01425 GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009987,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 3.5.1.2 0.000000000000000000000000000000000001179 143.0
HKD2_k127_925250_0 PFAM Rh family protein ammonium transporter K03320 - - 3.97e-215 680.0
HKD2_k127_925250_1 PFAM Short-chain dehydrogenase reductase SDR - - - 0.00000000000000000000000604 105.0
HKD2_k127_925250_2 Ion channel - - - 0.0000000000000000000002517 107.0
HKD2_k127_9257536_0 Deoxyhypusine synthase K00809 - 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 473.0
HKD2_k127_9257536_1 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005603 371.0
HKD2_k127_9257536_2 Porphyromonas-type peptidyl-arginine deiminase K10536 - 3.5.3.12 0.000000000000000006946 86.0
HKD2_k127_9257536_3 6-phosphogluconolactonase K01057 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 0.00000003876 55.0
HKD2_k127_9283803_0 Protein of unknown function (DUF3141) - - - 6.654e-194 617.0
HKD2_k127_9283803_1 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000002161 197.0
HKD2_k127_9286073_0 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001155 255.0
HKD2_k127_9286073_1 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000009727 182.0
HKD2_k127_9286073_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000966 159.0
HKD2_k127_9286073_3 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000007636 130.0
HKD2_k127_9286073_4 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000005569 128.0
HKD2_k127_9286073_5 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000000004866 105.0
HKD2_k127_9286073_6 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000101 54.0
HKD2_k127_92924_0 Domains REC, sigma54 interaction, HTH8 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 349.0
HKD2_k127_92924_1 Histidine kinase K02482,K07638 - 2.7.13.3 0.000000000000000000000000000000000000000000000001157 191.0
HKD2_k127_9312674_0 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K15582,K16201 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001444 274.0
HKD2_k127_9312674_1 imidazoleglycerol-phosphate dehydratase activity K01693 GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000007551 247.0
HKD2_k127_9312674_2 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.00000000000000000000000000000000000000000000000000000000000000000002332 238.0
HKD2_k127_9312674_3 PFAM Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000000000000000000000000000000000147 213.0
HKD2_k127_9312674_4 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000009336 88.0
HKD2_k127_9328229_0 DNA RNA non-specific endonuclease - - - 0.00000000000003929 85.0
HKD2_k127_9336940_0 D-alanine [D-alanyl carrier protein] ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 503.0
HKD2_k127_9336940_1 Catalyzes the reversible phosphorylation of UMP to UDP K09903 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009368 313.0
HKD2_k127_9336940_2 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007283 304.0
HKD2_k127_9336940_3 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001228 264.0
HKD2_k127_9336940_4 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000299 202.0
HKD2_k127_9336940_5 Diacylglycerol kinase catalytic domain (presumed) - - - 0.0000000000000000000000000000000000000000000000003654 188.0
HKD2_k127_9336940_6 Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family K00655 - 2.3.1.51 0.000000000000000000000000000000000000000001736 165.0
HKD2_k127_9336940_7 Phosphoglycerate mutase family - - - 0.0000000000000000000000000000000006881 137.0
HKD2_k127_9340836_0 NurA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 336.0
HKD2_k127_9340836_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 0.0000000000000000001066 89.0
HKD2_k127_9340836_2 - - - - 0.0000000000000000297 88.0
HKD2_k127_9359401_0 PFAM Mannosyl oligosaccharide glucosidase - - - 6e-323 998.0
HKD2_k127_9392656_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006788 312.0
HKD2_k127_9392656_1 Cation efflux family K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009334 259.0
HKD2_k127_9392656_2 GAF domain - - - 0.0000000000000000000000000000000000000000000000005768 195.0
HKD2_k127_9392656_3 SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity K03547 - - 0.00000000000000000000000000000001679 134.0
HKD2_k127_9392789_0 FecR protein - - - 7.4e-323 1015.0
HKD2_k127_9432945_0 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004072 385.0
HKD2_k127_9432945_1 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide - - - 0.00000000000000000000000000000000000000000000000000000000000000001654 234.0
HKD2_k127_9447819_0 PFAM DAHP synthetase I KDSA K03856,K04516 - 2.5.1.54,5.4.99.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003177 447.0
HKD2_k127_9447819_1 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000001434 222.0
HKD2_k127_9447819_2 Belongs to the 'phage' integrase family K03733 - - 0.0000000000000000000000000000000000000000000000000009099 192.0
HKD2_k127_9447819_3 antibiotic catabolic process K13277 - - 0.00000000000000000000000000000000000001127 157.0
HKD2_k127_9447819_4 Belongs to the 'phage' integrase family - - - 0.0000000000000001479 88.0
HKD2_k127_9465969_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006149 426.0
HKD2_k127_9465969_1 transferase activity, transferring glycosyl groups K13693,K21349 - 2.4.1.266,2.4.1.268 0.0000000000007459 69.0
HKD2_k127_9475664_0 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.00000000000000000000000006246 117.0
HKD2_k127_9488334_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18299 - - 0.0 1242.0
HKD2_k127_9488334_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 404.0
HKD2_k127_9492841_0 ATPase P-type (Transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000757 246.0
HKD2_k127_9492841_1 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000007142 202.0
HKD2_k127_9498824_0 - - - - 0.000000000000000000006757 102.0
HKD2_k127_9498824_1 phospholipase Carboxylesterase - - - 0.0000000000000003008 92.0
HKD2_k127_9498824_2 Belongs to the glycosyl hydrolase 13 family - - - 0.0000000000008402 81.0
HKD2_k127_9498824_3 thiolester hydrolase activity K06889 - - 0.00000000072 70.0
HKD2_k127_9498824_4 X-Pro dipeptidyl-peptidase (S15 family) K06889,K07397 - - 0.000002004 59.0
HKD2_k127_951776_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 587.0
HKD2_k127_951776_1 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001807 549.0
HKD2_k127_951776_2 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000662 357.0
HKD2_k127_951776_3 Cupin domain - - - 0.0000000000000000000000000000000000000000000000000004575 186.0
HKD2_k127_951776_4 ATPases associated with a variety of cellular activities K02003 - - 0.000000000000000000000000000000000000000000000002707 175.0
HKD2_k127_951776_5 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000204 109.0
HKD2_k127_9519222_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07636 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006556 412.0
HKD2_k127_9519222_1 Prephenate dehydratase K14170 GO:0003674,GO:0003824,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 351.0
HKD2_k127_9519222_2 PFAM response regulator receiver K07657,K07663 - - 0.00000000000000000001751 92.0
HKD2_k127_9519222_3 - - - - 0.00000000000000008728 84.0
HKD2_k127_9519222_4 - - - - 0.0001598 51.0
HKD2_k127_9538868_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 9.655e-313 971.0
HKD2_k127_9538868_1 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 423.0
HKD2_k127_9538868_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006793 331.0
HKD2_k127_9557902_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 8.295e-264 822.0
HKD2_k127_9557902_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001734 316.0
HKD2_k127_9557902_2 - - - - 0.00000000000001077 80.0
HKD2_k127_9558264_0 Putative Na+/H+ antiporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 507.0
HKD2_k127_9558264_1 AMP binding - - - 0.000000000000000000000000000000000000000000323 166.0
HKD2_k127_9558466_0 PFAM CBS domain K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002847 262.0
HKD2_k127_9573593_0 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003076 317.0
HKD2_k127_9573593_1 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.00000000000000000000000000000009396 138.0
HKD2_k127_9576462_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006058 566.0
HKD2_k127_9587736_0 Aerotolerance regulator N-terminal - - - 0.00000000000000000000000000000000000000000000000000000000002327 227.0
HKD2_k127_9591372_0 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 353.0
HKD2_k127_9591372_1 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.000000000000000000000000000000000000000283 153.0
HKD2_k127_9591372_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 0.0001496 44.0
HKD2_k127_9599068_0 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 396.0
HKD2_k127_9599068_1 Ribosomal protein L11 methyltransferase K02687 - - 0.00000000000000000000000000000000000000001304 160.0
HKD2_k127_9599068_2 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000000000000000002377 111.0
HKD2_k127_9611676_0 AIR synthase related protein domain protein K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002819 415.0
HKD2_k127_9611676_1 Glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000008344 183.0
HKD2_k127_9611676_2 TonB C terminal K03832 - - 0.0000000000000000000007465 106.0
HKD2_k127_9612106_0 leucyltransferase activity K00684 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002989 273.0
HKD2_k127_9612106_1 GDSL-like Lipase/Acylhydrolase family - - - 0.0000000000000000000000000000000000002778 147.0
HKD2_k127_9612106_2 Rdx family K07401 - - 0.000000000000000000000000000000000001838 139.0
HKD2_k127_9612106_3 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000007288 116.0
HKD2_k127_9613651_0 Molybdopterin oxidoreductase Fe4S4 domain K08357 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000671 415.0
HKD2_k127_9613651_1 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000001755 145.0
HKD2_k127_9645069_0 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067,K06192 - - 0.0000000000000000000000000000000000557 141.0
HKD2_k127_9645069_1 ABC-type transport auxiliary lipoprotein component K18480 - - 0.000000000000000000000000004557 118.0
HKD2_k127_9645069_2 Bacterial protein of unknown function (DUF945) - - - 0.000000000005016 78.0
HKD2_k127_9645737_0 aminopeptidase activity K01179 - 3.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000001776 229.0
HKD2_k127_9645737_1 exonuclease of the beta-lactamase fold involved in RNA processing K07577 - - 0.0001838 52.0
HKD2_k127_9646928_0 Alpha/beta hydrolase family K22318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007994 404.0
HKD2_k127_9646928_1 Aromatic acid exporter family member 1 - - - 0.0000000000000000000000000000002489 129.0
HKD2_k127_9652487_0 translation elongation factor activity K02358,K15771 GO:0001666,GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009274,GO:0009275,GO:0009628,GO:0009986,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010339,GO:0010467,GO:0016020,GO:0019538,GO:0019899,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0034641,GO:0034645,GO:0035375,GO:0035821,GO:0036293,GO:0040007,GO:0042221,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044444,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0070482,GO:0071704,GO:0071944,GO:0090087,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005215 370.0
HKD2_k127_9652487_1 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.00000000000000000000000000000001941 127.0
HKD2_k127_9658053_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003699 299.0
HKD2_k127_9658053_1 domain protein - - - 0.0000000000000000000000000000000008345 135.0
HKD2_k127_966846_0 Pyridoxamine 5'-phosphate oxidase K07226 - - 0.0000000000000000000000000000000000000000000000000000000000000003025 225.0
HKD2_k127_966846_1 FAD dependent oxidoreductase K00273 - 1.4.3.3 0.000000000000000000000000000000000003036 141.0
HKD2_k127_9669430_0 alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 574.0
HKD2_k127_9669430_1 Belongs to the MIP aquaporin (TC 1.A.8) family K06188 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001551 273.0
HKD2_k127_9669430_2 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000001581 111.0
HKD2_k127_9675213_0 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000468 255.0
HKD2_k127_9675213_1 ECF sigma factor - - - 0.0000000000000000000000000000000000000000008037 164.0
HKD2_k127_9675213_2 Heavy-metal resistance - - - 0.0000001824 58.0
HKD2_k127_9692319_0 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 509.0
HKD2_k127_9703902_0 PFAM cyclase family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000001719 224.0
HKD2_k127_9703902_1 Allergen V5 Tpx-1 family protein - - - 0.0000000000000000000000000000000002732 137.0
HKD2_k127_9708754_0 Domain present in carbohydrate binding proteins and sugar hydrolses K07218 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008939 269.0
HKD2_k127_9708754_1 lipoprotein involved in nitrous oxide reduction K19342 - - 0.0000000000000000000000000002248 115.0
HKD2_k127_9723322_0 AMP-binding enzyme C-terminal domain K02182 - 6.2.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000007658 267.0
HKD2_k127_9723322_1 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000001545 90.0
HKD2_k127_9723322_2 PFAM AMP-dependent synthetase and ligase K02182 - 6.2.1.48 0.0000000000000000058 89.0
HKD2_k127_9725257_0 FAD linked oxidases, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008557 539.0
HKD2_k127_9725257_1 Guanylyl transferase CofC like K14941 - 2.7.7.68 0.0000000000000000000000003095 111.0
HKD2_k127_9726650_0 Sodium/hydrogen exchanger family K11105 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 406.0
HKD2_k127_9726650_1 heme binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005236 319.0
HKD2_k127_9726650_2 PFAM AAA ATPase central domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 295.0
HKD2_k127_9726650_3 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000007121 185.0
HKD2_k127_9726650_4 Short repeat of unknown function (DUF308) - - - 0.00000000000000000000000000000000003476 140.0
HKD2_k127_9726650_5 Beta-lactamase K01286 - 3.4.16.4 0.0000000000000004613 81.0
HKD2_k127_9726650_6 Sodium/hydrogen exchanger family K11105 - - 0.00000000007094 67.0
HKD2_k127_9730149_0 Predicted periplasmic protein (DUF2092) - - - 0.0000000000000000000000000000000000000000000000002298 186.0
HKD2_k127_9730149_1 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01537 - 3.6.3.8 0.00000000000000000000000000000000004851 137.0
HKD2_k127_9730149_2 - - - - 0.000000000000000000000001984 113.0
HKD2_k127_9730149_3 - - - - 0.0000000000006303 70.0
HKD2_k127_9730489_0 NhaP-type Na H and K H - - - 3.315e-196 629.0
HKD2_k127_9730489_1 NADH dehydrogenase, FAD-containing subunit K03885 - 1.6.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 571.0
HKD2_k127_9730489_2 NhaP-type Na H and K H - - - 0.0000000000000000000000000000000000000000000000000000000000000000001482 238.0
HKD2_k127_9730489_3 NhaP-type Na H and K H - - - 0.00000000000000000000000000000000000000000000647 166.0
HKD2_k127_9730489_4 MgtC family K07507 - - 0.0000000000000000000000000000003068 131.0
HKD2_k127_9730489_5 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.000000008694 59.0
HKD2_k127_973976_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008882 331.0
HKD2_k127_973976_1 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K13799 GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25,6.3.2.1 0.0000000000000000000000000000000000000000000000000000002065 201.0
HKD2_k127_9742606_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000269 255.0
HKD2_k127_9742606_1 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000001397 244.0
HKD2_k127_9742606_2 PFAM sigma-54 factor interaction domain-containing protein - - - 0.00000000000000000000000000000000000000000008707 184.0
HKD2_k127_9742606_3 - - - - 0.000000000405 62.0
HKD2_k127_9742606_4 - - - - 0.000000000476 63.0
HKD2_k127_9747161_0 TIGRFAM phenylalanyl-tRNA synthetase, beta subunit K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 540.0
HKD2_k127_9749958_0 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000003181 245.0
HKD2_k127_9749958_1 Crossover junction endodeoxyribonuclease RuvC K01159 GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 0.0000000000000000000000000000000000000000001392 165.0
HKD2_k127_9749958_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000004592 150.0
HKD2_k127_9752614_0 Belongs to the AAA ATPase family K13525 - - 1.686e-196 624.0
HKD2_k127_9752614_1 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.000000000000000000000000000004527 121.0
HKD2_k127_9752751_0 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 408.0
HKD2_k127_9752751_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 GO:0000166,GO:0003674,GO:0005215,GO:0005315,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008144,GO:0008150,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0017076,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035303,GO:0035435,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0097159,GO:0097367,GO:0098656,GO:0098660,GO:0098661,GO:1901265,GO:1901363 3.6.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 399.0
HKD2_k127_9752751_2 phosphate transport system permease K02038 GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 387.0
HKD2_k127_9752751_3 Domain of unknown function (DUF4186) - - - 0.00000000000000000000000000000000004817 138.0
HKD2_k127_9752751_4 Transcriptional regulator with HTH domain - - - 0.00000000007568 68.0
HKD2_k127_9753964_0 Protein involved in outer membrane biogenesis K09800 - - 0.000000000000000002058 102.0
HKD2_k127_9753964_1 Protein of unknown function (DUF1318) K09978 - - 0.00000000000000002022 91.0
HKD2_k127_9754720_0 PFAM Alcohol dehydrogenase GroES-like domain K00121,K00148 - 1.1.1.1,1.1.1.284,1.2.1.46 0.000000000000000006066 86.0
HKD2_k127_9762385_0 Phosphoribosylglycinamide synthetase, C domain K01945 - 6.3.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002239 539.0
HKD2_k127_9762385_1 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000002688 129.0
HKD2_k127_9762385_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.00000000000000000002712 92.0
HKD2_k127_976920_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 348.0
HKD2_k127_976920_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000000000000000000000001436 160.0
HKD2_k127_976920_2 Belongs to the Dps family K04047 - - 0.000000000000000000000000000000002448 132.0
HKD2_k127_976920_3 Pfam:DUF59 - - - 0.0000000000000000000000001996 111.0
HKD2_k127_976920_4 DnaJ C terminal domain K05516 - - 0.0000000000000002274 79.0
HKD2_k127_9774019_0 ABC transporter K06158 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000736 430.0
HKD2_k127_9774019_1 Peptidase C26 K07010 - - 0.000000000000000000000000000000000000000000000000001461 191.0
HKD2_k127_9788249_0 Large extracellular alpha-helical protein - - - 4.448e-256 814.0
HKD2_k127_9788249_1 Uncharacterised conserved protein (DUF2156) K07027,K14205 - 2.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000832 224.0
HKD2_k127_9788249_2 pyrroloquinoline quinone binding - - - 0.0000000000000000192 89.0
HKD2_k127_9788249_3 - - - - 0.000005437 53.0
HKD2_k127_9788249_4 PFAM peptidase U6 penicillin-insensitive murein endopeptidase K07261 - - 0.0001025 46.0
HKD2_k127_9788768_0 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001204 479.0
HKD2_k127_9789958_0 abc-type fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007863 292.0
HKD2_k127_9789958_1 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000001635 228.0
HKD2_k127_9789958_2 PFAM ABC transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000002 203.0
HKD2_k127_9789958_3 PFAM periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000001136 174.0
HKD2_k127_9789958_4 Lactonase, 7-bladed beta-propeller K07004 - - 0.000000001984 70.0
HKD2_k127_9822295_0 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000007964 196.0
HKD2_k127_9824336_0 type IV pilus secretin PilQ K02666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004482 423.0
HKD2_k127_9824336_1 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 415.0
HKD2_k127_9824336_2 - - - - 0.0000000000000000000000000000000000000000000000000000001754 205.0
HKD2_k127_9824336_3 B12 binding domain K01849 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000001041 192.0
HKD2_k127_9824336_4 PFAM Pilus assembly protein PilO K02664 - - 0.00000000000000000002448 96.0
HKD2_k127_9824336_5 - - - - 0.0000000000002445 78.0
HKD2_k127_9824336_6 assembly protein K02665 - - 0.0000000004778 68.0
HKD2_k127_984826_0 PFAM PfkB domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 377.0
HKD2_k127_984826_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 374.0
HKD2_k127_984826_2 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005411 371.0
HKD2_k127_984826_3 Catalyzes the NAD( )-dependent oxidative deamination of L-alanine to pyruvate, and the reverse reaction, the reductive amination of pyruvate K01750,K19244 - 1.4.1.1,4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005786 305.0
HKD2_k127_984826_4 Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate K03272 GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000001236 240.0
HKD2_k127_984826_5 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.000000000000000000000000000000000001982 144.0
HKD2_k127_984826_6 Metal-sensitive transcriptional repressor - - - 0.000000000000000000000001384 105.0
HKD2_k127_984826_7 Tetratricopeptide TPR_2 - - - 0.0000000000000000002781 98.0
HKD2_k127_9855341_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 413.0
HKD2_k127_9855341_1 Domain of unknown function (DUF4340) - - - 0.00001781 51.0
HKD2_k127_9874464_0 Amino acid permease K16238 - - 3.068e-207 667.0
HKD2_k127_9874464_1 transferase activity, transferring glycosyl groups K13693,K21349 - 2.4.1.266,2.4.1.268 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004781 471.0
HKD2_k127_9879135_0 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000002279 262.0
HKD2_k127_9879135_1 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000000001223 234.0
HKD2_k127_9879135_2 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.000000000000000000000009985 104.0
HKD2_k127_9879135_3 Protein of unknown function (DUF503) K09764 - - 0.000000618 51.0
HKD2_k127_9879281_0 Methyltransferase K18911 - 2.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007568 305.0
HKD2_k127_9879281_1 COGs COG2343 conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000624 243.0
HKD2_k127_9879281_2 COG1125 ABC-type proline glycine betaine transport systems ATPase components K05847 - - 0.000000000000000000000000000000000000000000000003974 176.0
HKD2_k127_9911186_0 PFAM Histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005524 353.0
HKD2_k127_9911186_1 DNA-dependent DNA replication K02315,K04076 - 3.4.21.53 0.00000000000000000000000000000000009997 138.0
HKD2_k127_992584_0 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000006264 166.0
HKD2_k127_992584_1 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 0.0000000000000000000000000001628 118.0
HKD2_k127_992584_2 Domain of unknown function (DUF4442) K02614 - - 0.00000000000000000000002799 104.0
HKD2_k127_9939514_0 PFAM methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002279 415.0
HKD2_k127_9968357_0 COG0043 3-polyprenyl-4-hydroxybenzoate decarboxylase and K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 355.0
HKD2_k127_9968357_1 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate K18285 - 2.5.1.120 0.0000000000000000000000000000000000000000000000002923 182.0
HKD2_k127_9981304_0 RNB K01147 - 3.1.13.1 0.000000000000000000000000000000000000000000000001607 186.0
HKD2_k127_9991083_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657,K13503 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 604.0
HKD2_k127_9991083_1 with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine K01664 GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004431 297.0
HKD2_k127_9991083_2 AMP-binding enzyme C-terminal domain K02182 - 6.2.1.48 0.000000000000000000000000000000000000000000000000000005935 206.0