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Overview

ID MAG01798
Name HKD2_bin.45
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Alphaproteobacteria
Order Sphingomonadales
Family Sphingomonadaceae
Genus Novosphingobium
Species
Assembly information
Completeness (%) 74.06
Contamination (%) 1.83
GC content (%) 66.0
N50 (bp) 16,645
Genome size (bp) 2,346,736

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2299

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_1063652_0 Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides K03684 - 3.1.13.5 3.359e-209 655.0
HKD2_k127_1063652_1 Transcriptional regulator K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000385 537.0
HKD2_k127_1063652_2 Integrase core domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008584 334.0
HKD2_k127_1063652_3 PAP2 superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 292.0
HKD2_k127_1145902_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1923.0
HKD2_k127_1145902_1 peptidase M13 K07386 - - 3.997e-314 983.0
HKD2_k127_1145902_10 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008089 335.0
HKD2_k127_1145902_11 COG0760 Parvulin-like peptidyl-prolyl isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 317.0
HKD2_k127_1145902_12 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004162 275.0
HKD2_k127_1145902_13 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.00000000000000000000000000000000000000000000000000000000000000000000004349 241.0
HKD2_k127_1145902_14 Acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000009537 204.0
HKD2_k127_1145902_15 - - - - 0.000000000000000000000000000000000000000000000000002087 190.0
HKD2_k127_1145902_16 Domain of unknown function (DUF4170) - - - 0.00000000000000000000000000000000008081 134.0
HKD2_k127_1145902_17 - - - - 0.00000000001301 73.0
HKD2_k127_1145902_18 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.0000000002075 66.0
HKD2_k127_1145902_2 Protein of unknown function (DUF3604) - - - 3.173e-299 930.0
HKD2_k127_1145902_3 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 4.018e-238 741.0
HKD2_k127_1145902_4 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 3.145e-216 677.0
HKD2_k127_1145902_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 561.0
HKD2_k127_1145902_6 Ecdysteroid kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000751 453.0
HKD2_k127_1145902_7 HupE / UreJ protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000123 417.0
HKD2_k127_1145902_8 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 359.0
HKD2_k127_1145902_9 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001632 341.0
HKD2_k127_117875_0 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 0.0 1197.0
HKD2_k127_117875_1 acetyl propionyl-CoA carboxylase, alpha subunit K01965 - 6.4.1.3 0.0 1184.0
HKD2_k127_117875_10 Chloride channel K03281 - - 9.902e-199 634.0
HKD2_k127_117875_11 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735 - 4.2.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 597.0
HKD2_k127_117875_12 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009034 519.0
HKD2_k127_117875_13 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005724 479.0
HKD2_k127_117875_14 Belongs to the 'phage' integrase family K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 427.0
HKD2_k127_117875_15 NAD(P)H-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000691 428.0
HKD2_k127_117875_16 Enoyl-(Acyl carrier protein) reductase K14189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002049 370.0
HKD2_k127_117875_17 GTP cyclohydrolase K01495 - 3.5.4.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003516 366.0
HKD2_k127_117875_18 enoyl-CoA hydratase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 348.0
HKD2_k127_117875_19 methylmalonyl-CoA epimerase K05606 - 5.1.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002934 286.0
HKD2_k127_117875_2 acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 1.329e-311 958.0
HKD2_k127_117875_20 Alkyl hydroperoxide reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001494 274.0
HKD2_k127_117875_21 Thioesterase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005624 267.0
HKD2_k127_117875_22 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000000000000004951 216.0
HKD2_k127_117875_23 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000000001185 194.0
HKD2_k127_117875_24 - - - - 0.000000000000000000000000000000000000000000008832 166.0
HKD2_k127_117875_25 - - - - 0.00000000000000000000000000000007302 127.0
HKD2_k127_117875_26 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.000000000000000000000000000002294 125.0
HKD2_k127_117875_27 Flp pilus assembly protein, pilin Flp K02651 - - 0.00000000000006231 74.0
HKD2_k127_117875_28 Pilus assembly protein K02651 - - 0.000000001415 61.0
HKD2_k127_117875_3 O-acetylhomoserine K01738,K01740 - 2.5.1.47,2.5.1.49 7.113e-254 785.0
HKD2_k127_117875_30 - - - - 0.0002033 49.0
HKD2_k127_117875_4 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 2.383e-244 760.0
HKD2_k127_117875_5 Transcriptional regulator K21686 - - 2.017e-227 712.0
HKD2_k127_117875_6 amino acid peptide transporter K03305 - - 3.707e-227 713.0
HKD2_k127_117875_7 peptidase M48, Ste24p - - - 9.754e-206 651.0
HKD2_k127_117875_8 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 9.287e-203 642.0
HKD2_k127_117875_9 - - - - 9.937e-200 639.0
HKD2_k127_1204469_0 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 612.0
HKD2_k127_1204469_1 phosphate transport system permease K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 568.0
HKD2_k127_1204469_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002165 460.0
HKD2_k127_1204469_3 Phosphate ABC transporter substrate-binding protein K02040 - - 0.0000004232 51.0
HKD2_k127_127633_0 Retinal pigment epithelial membrane protein K11159 - - 2.275e-293 917.0
HKD2_k127_127633_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine K00641 - 2.3.1.31 2.436e-198 623.0
HKD2_k127_127633_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 602.0
HKD2_k127_127633_3 Major Facilitator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001888 471.0
HKD2_k127_127633_4 Dual function enzyme catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate and the formation of tyrosine from arogenate K00220 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 405.0
HKD2_k127_127633_5 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000392 344.0
HKD2_k127_127633_6 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002584 316.0
HKD2_k127_127633_7 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000000000000000000000000000000000000000001085 221.0
HKD2_k127_127633_8 COG0346 Lactoylglutathione lyase and related lyases - - - 0.00000000000000000000000000000000000000000000000000000000000002406 215.0
HKD2_k127_127633_9 Protein of unknown function (DUF3237) - - - 0.000000000000000000000000000000000000000000000000007922 188.0
HKD2_k127_1288112_0 Methylamine dehydrogenase heavy chain (MADH) K15229 - 1.4.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005878 587.0
HKD2_k127_1288112_1 BetI-type transcriptional repressor, C-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006156 321.0
HKD2_k127_1288112_2 Methylamine utilisation protein MauE - - - 0.0000000000000000000000000000000000000001871 156.0
HKD2_k127_1288112_3 methylamine dehydrogenase accessory protein MauD - - - 0.000005084 54.0
HKD2_k127_129196_0 E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate K00164 - 1.2.4.2 0.0 1624.0
HKD2_k127_129196_1 Peptidase family M3 K01284 - 3.4.15.5 1.507e-268 846.0
HKD2_k127_129196_10 Periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001328 299.0
HKD2_k127_129196_11 peptidase M13 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 284.0
HKD2_k127_129196_12 ABC transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000005301 278.0
HKD2_k127_129196_14 - - - - 0.000000000005943 71.0
HKD2_k127_129196_2 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 3.812e-251 780.0
HKD2_k127_129196_3 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 3.098e-224 712.0
HKD2_k127_129196_4 receptor K16092 - - 1.372e-208 666.0
HKD2_k127_129196_5 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004128 580.0
HKD2_k127_129196_6 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 572.0
HKD2_k127_129196_7 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001511 524.0
HKD2_k127_129196_8 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 481.0
HKD2_k127_129196_9 Cell Wall - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000876 404.0
HKD2_k127_1301989_0 WD40-like Beta Propeller Repeat - - - 2.935e-265 841.0
HKD2_k127_1301989_1 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit K01844 - 5.4.3.3 2.99e-236 745.0
HKD2_k127_1301989_10 Major Facilitator Superfamily K08169 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000332 490.0
HKD2_k127_1301989_11 L-lactate dehydrogenase K00101 - 1.1.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007765 480.0
HKD2_k127_1301989_12 Zinc-binding dehydrogenase K18012 - 1.4.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008614 420.0
HKD2_k127_1301989_13 transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004218 402.0
HKD2_k127_1301989_14 3-keto-5-aminohexanoate cleavage protein K18013 - 2.3.1.247 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006921 391.0
HKD2_k127_1301989_15 Dimerisation domain of d-ornithine 4,5-aminomutase K18011 - 5.4.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003087 362.0
HKD2_k127_1301989_16 Amino acid permease K03759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000568 351.0
HKD2_k127_1301989_17 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007225 306.0
HKD2_k127_1301989_18 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003743 256.0
HKD2_k127_1301989_19 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003302 278.0
HKD2_k127_1301989_2 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 1.01e-230 724.0
HKD2_k127_1301989_20 Thioesterase superfamily K18014 - 4.3.1.14 0.00000000000000000000000000000000000000000000000000000000003599 208.0
HKD2_k127_1301989_21 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase K00950 - 2.7.6.3 0.0000000000000000000000000000000000000000000000000000000004382 207.0
HKD2_k127_1301989_22 - - - - 0.000000000000000000000000000000000000003759 151.0
HKD2_k127_1301989_23 Protein of unknown function (DUF1674) - - - 0.0000000000000000003322 87.0
HKD2_k127_1301989_24 aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K07303 - 1.3.99.16 0.000000000211 61.0
HKD2_k127_1301989_3 Cytochrome p450 - - - 6.285e-217 690.0
HKD2_k127_1301989_4 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 9.92e-204 640.0
HKD2_k127_1301989_5 TonB-dependent receptor K02014 - - 1.134e-203 640.0
HKD2_k127_1301989_6 FAD linked oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 531.0
HKD2_k127_1301989_7 N-carbamoylputrescine amidase K12251 - 3.5.1.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 517.0
HKD2_k127_1301989_8 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004441 514.0
HKD2_k127_1301989_9 COG1228 Imidazolonepropionase and related amidohydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 494.0
HKD2_k127_1310398_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.0 1216.0
HKD2_k127_1310398_1 Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase) K09883 - 6.6.1.2 4.365e-298 923.0
HKD2_k127_1310398_10 Belongs to the GST superfamily K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004401 275.0
HKD2_k127_1310398_11 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006424 263.0
HKD2_k127_1310398_12 Protein of unknown function (DUF4197) - - - 0.00000000000000000000000000000000000000000000000000000000000000000002016 241.0
HKD2_k127_1310398_13 Protein of unknown function (DUF1203) - - - 0.000000000000000000000000000000000000000000000000004901 205.0
HKD2_k127_1310398_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 2.724e-261 817.0
HKD2_k127_1310398_3 Metal binding domain of Ada K10778 - 2.1.1.63 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 527.0
HKD2_k127_1310398_4 Trypsin-like serine protease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 504.0
HKD2_k127_1310398_5 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007824 395.0
HKD2_k127_1310398_6 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007147 347.0
HKD2_k127_1310398_7 Dienelactone hydrolase family K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 352.0
HKD2_k127_1310398_8 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004127 282.0
HKD2_k127_1310398_9 CAAX protease self-immunity K07052 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002758 292.0
HKD2_k127_1326390_0 DNA helicase K03657 - 3.6.4.12 0.0 1304.0
HKD2_k127_1326390_1 Belongs to the DEAD box helicase family - - - 1.204e-224 702.0
HKD2_k127_1326390_2 Ring hydroxylating alpha subunit (catalytic domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006536 578.0
HKD2_k127_1326390_3 Transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000817 578.0
HKD2_k127_1326390_4 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 507.0
HKD2_k127_1326390_5 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000455 401.0
HKD2_k127_1326390_6 Acetyl-coenzyme A transporter 1 K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001548 294.0
HKD2_k127_1326390_7 Methyltransferase K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005501 272.0
HKD2_k127_1331210_0 cytochrome C K02198 - - 2.034e-310 962.0
HKD2_k127_1331210_1 heat shock protein binding - - - 6.808e-275 866.0
HKD2_k127_1331210_2 heat shock protein binding - - - 1.793e-251 802.0
HKD2_k127_1331210_3 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 1.592e-249 800.0
HKD2_k127_1331210_4 cytochrome c biogenesis K02200 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 332.0
HKD2_k127_1331210_5 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 300.0
HKD2_k127_1331210_6 Alkyl hydroperoxide reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000289 232.0
HKD2_k127_1331210_7 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000007606 218.0
HKD2_k127_1331210_8 subunit of a heme lyase K02200 - - 0.000000000000000000000000000000000000000000002295 168.0
HKD2_k127_1338047_0 Respiratory nitrate reductase alpha N-terminal - - - 0.0 2384.0
HKD2_k127_1338047_1 TonB dependent receptor K02014 - - 0.0 1120.0
HKD2_k127_1338047_10 helix_turn _helix lactose operon repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004898 436.0
HKD2_k127_1338047_11 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007323 384.0
HKD2_k127_1338047_12 dehydrogenase light chain K15228 GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.4.9.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004142 348.0
HKD2_k127_1338047_13 Nitrate reductase gamma subunit K00374 - 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001647 348.0
HKD2_k127_1338047_14 COG3121 P pilus assembly protein, chaperone PapD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 325.0
HKD2_k127_1338047_15 methylamine dehydrogenase accessory protein MauD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001312 303.0
HKD2_k127_1338047_16 PPIC-type PPIASE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003214 287.0
HKD2_k127_1338047_17 PFAM Enoyl-CoA hydratase isomerase family - - - 0.000000000000000000000000000000000000000000000000000000000000001399 227.0
HKD2_k127_1338047_18 Nitrate reductase delta subunit - - - 0.0000000000000000000000000000000000000000000000000000000001064 216.0
HKD2_k127_1338047_19 Cytochrome c class I - - - 0.000000000000000000000000000000000000000000000000000001012 197.0
HKD2_k127_1338047_2 Major Facilitator Superfamily - - - 0.0 1098.0
HKD2_k127_1338047_20 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000002206 192.0
HKD2_k127_1338047_21 Domain of unknown function (DUF4402) - - - 0.0000000000000000000000000000000002966 137.0
HKD2_k127_1338047_23 Domain of unknown function (DUF4402) - - - 0.00000000000000000001571 99.0
HKD2_k127_1338047_3 TonB dependent receptor - - - 5e-323 1005.0
HKD2_k127_1338047_4 Respiratory nitrate reductase beta C-terminal - - - 3.073e-315 976.0
HKD2_k127_1338047_5 AMP-binding enzyme C-terminal domain K00666 - - 5.122e-305 940.0
HKD2_k127_1338047_6 Glycosyl hydrolase family K01187 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.20 8.538e-243 759.0
HKD2_k127_1338047_7 usher protein - - - 1.146e-242 797.0
HKD2_k127_1338047_8 belongs to the aldehyde dehydrogenase family - - - 5.608e-235 739.0
HKD2_k127_1338047_9 - - - - 9.583e-206 661.0
HKD2_k127_1346605_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1485.0
HKD2_k127_1346605_1 Acetoacetyl-CoA reductase K00023 - 1.1.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 441.0
HKD2_k127_1346605_2 Lipopolysaccharide-assembly K03643 - - 0.000000000000000000000000000000000000000000000000000000000000000001049 233.0
HKD2_k127_1346605_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000003255 233.0
HKD2_k127_1346605_4 Domain of unknown function (DUF3576) - - - 0.0000000000000000000000000000000000000000000000000000000000000004844 223.0
HKD2_k127_1346605_5 Protein of unknown function (DUF4019) - - - 0.00000000000000000000000001222 109.0
HKD2_k127_1346605_6 DNA polymerase III K02340 - 2.7.7.7 0.000001141 55.0
HKD2_k127_1359252_0 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family K09461 - 1.14.13.40 3.398e-319 997.0
HKD2_k127_1359252_1 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000776 563.0
HKD2_k127_1359252_2 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006439 450.0
HKD2_k127_1359252_3 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007019 280.0
HKD2_k127_1359252_4 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000000000000000000000000000000000000000000000000002748 191.0
HKD2_k127_1359252_5 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000166 165.0
HKD2_k127_1359252_6 transcriptional regulator - - - 0.00000000000000000000000000000000001501 141.0
HKD2_k127_1359252_7 Thioesterase K01075 - 3.1.2.23 0.000008462 57.0
HKD2_k127_136162_0 helicase K03724 - - 0.0 1328.0
HKD2_k127_136162_1 aminopeptidase N K01256 - 3.4.11.2 0.0 1327.0
HKD2_k127_136162_10 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 316.0
HKD2_k127_136162_11 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000001637 270.0
HKD2_k127_136162_12 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000006729 235.0
HKD2_k127_136162_13 Biopolymer transport protein K03559 - - 0.00000000000000000000000000000000000000006363 153.0
HKD2_k127_136162_14 Heat shock protein DnaJ domain protein - - - 0.000000000000000000000000000004853 121.0
HKD2_k127_136162_2 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 7.622e-246 762.0
HKD2_k127_136162_3 phosphomannomutase K01840 - 5.4.2.8 7.071e-245 762.0
HKD2_k127_136162_4 involved in chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002674 428.0
HKD2_k127_136162_5 Domain of unknown function (DUF4010) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 430.0
HKD2_k127_136162_6 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001394 410.0
HKD2_k127_136162_7 epimerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009309 381.0
HKD2_k127_136162_8 Cytochrome c1 K00413 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005424 367.0
HKD2_k127_136162_9 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000603 351.0
HKD2_k127_1363654_0 Glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 2760.0
HKD2_k127_1363654_1 5-methyltetrahydrofolate--homocysteine methyltransferase K00548 - 2.1.1.13 0.0 1516.0
HKD2_k127_1363654_10 Bacterial protein of unknown function (DUF853) K06915 - - 1.374e-267 832.0
HKD2_k127_1363654_11 Belongs to the thiolase family K00626 - 2.3.1.9 9.428e-240 744.0
HKD2_k127_1363654_12 de-polymerase K05973 - 3.1.1.75 2.875e-221 692.0
HKD2_k127_1363654_13 carnitine dehydratase K14470 - 5.4.1.3 3.324e-221 695.0
HKD2_k127_1363654_14 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 9.301e-212 662.0
HKD2_k127_1363654_15 Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate K00812 - 2.6.1.1 4.916e-206 646.0
HKD2_k127_1363654_16 acyl-CoA dehydrogenase K06446 - - 6.191e-197 620.0
HKD2_k127_1363654_17 COG3307 Lipid A core - O-antigen ligase and related enzymes - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001629 589.0
HKD2_k127_1363654_18 Glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 580.0
HKD2_k127_1363654_19 Methionine synthase I (cobalamin-dependent), methyltransferase domain K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007977 574.0
HKD2_k127_1363654_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 0.0 1389.0
HKD2_k127_1363654_20 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004111 557.0
HKD2_k127_1363654_21 Phenylalanine-4-hydroxylase K00500 - 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 554.0
HKD2_k127_1363654_22 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 544.0
HKD2_k127_1363654_23 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006685 523.0
HKD2_k127_1363654_24 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004754 524.0
HKD2_k127_1363654_25 ArsR family transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003113 500.0
HKD2_k127_1363654_26 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 493.0
HKD2_k127_1363654_27 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 473.0
HKD2_k127_1363654_28 alginic acid biosynthetic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 452.0
HKD2_k127_1363654_29 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 417.0
HKD2_k127_1363654_3 Malic enzyme K00029 - 1.1.1.40 0.0 1257.0
HKD2_k127_1363654_30 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005701 413.0
HKD2_k127_1363654_31 N-terminal half of MaoC dehydratase K09709 - 4.2.1.153 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 413.0
HKD2_k127_1363654_32 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009258 395.0
HKD2_k127_1363654_33 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 393.0
HKD2_k127_1363654_34 Pseudouridine synthase K06177 - 5.4.99.28,5.4.99.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002202 341.0
HKD2_k127_1363654_35 COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004945 331.0
HKD2_k127_1363654_36 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001781 269.0
HKD2_k127_1363654_37 MaoC like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000293 258.0
HKD2_k127_1363654_39 Bacterial transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000001628 231.0
HKD2_k127_1363654_4 DNA helicase K03654 - 3.6.4.12 1.876e-304 947.0
HKD2_k127_1363654_40 protein conserved in bacteria K09774 - - 0.0000000000000000000000000000000000000000000000000000000000003227 216.0
HKD2_k127_1363654_41 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000000000000000000000000000002606 220.0
HKD2_k127_1363654_42 chain release factor K15034 - - 0.0000000000000000000000000000000000000000000000000000000681 201.0
HKD2_k127_1363654_43 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.00000000000000000000000001524 110.0
HKD2_k127_1363654_44 - - - - 0.000000000000000000000000362 105.0
HKD2_k127_1363654_46 - - - - 0.0000000000000000002499 91.0
HKD2_k127_1363654_47 - - - - 0.000000000000000008168 96.0
HKD2_k127_1363654_5 ERAP1-like C-terminal domain - - - 5.552e-299 941.0
HKD2_k127_1363654_52 - - - - 0.00000115 55.0
HKD2_k127_1363654_6 ABC-type multidrug transport system, ATPase and permease K06147 - - 2.51e-277 863.0
HKD2_k127_1363654_7 Glutamate synthase K00266 - 1.4.1.13,1.4.1.14 3.354e-276 854.0
HKD2_k127_1363654_8 Acyl-CoA dehydrogenase, C-terminal domain K14448 - 1.3.8.12 3.948e-272 853.0
HKD2_k127_1363654_9 component I K01665,K03342 - 2.6.1.85,4.1.3.38 7.738e-270 847.0
HKD2_k127_1390786_0 nitrogen fixation sensor protein fixL K14986 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003584 501.0
HKD2_k127_1390786_1 DNA polymerase X family K02347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 299.0
HKD2_k127_1390786_2 Bacterial regulatory proteins, luxR family K14987 - - 0.000000000000000000000000000000000000000000000000000000000000000000000008547 258.0
HKD2_k127_1390786_3 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.000000000000000000000000000000000000000000000000000001833 205.0
HKD2_k127_1390786_4 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000000008084 166.0
HKD2_k127_1390786_5 Protein required for attachment to host cells - - - 0.000000000000000000000000000000000000004862 153.0
HKD2_k127_1390786_6 - - - - 0.00000000000000000000000000116 116.0
HKD2_k127_1390786_7 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.00000000000000000000000007187 112.0
HKD2_k127_1390786_8 Transcriptional regulator K15861 - - 0.0000000000000000000003642 105.0
HKD2_k127_140042_0 - - - - 2.33e-242 756.0
HKD2_k127_140042_1 Flavin-binding monooxygenase-like - - - 9.114e-227 711.0
HKD2_k127_140042_10 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 290.0
HKD2_k127_140042_11 Acyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 291.0
HKD2_k127_140042_12 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003071 260.0
HKD2_k127_140042_13 chorismate lyase activity - - - 0.0000000000000000000000000000000000000000000000009827 184.0
HKD2_k127_140042_14 Belongs to the peptidase S41A family - - - 0.000000000000000000000000000000000000002705 165.0
HKD2_k127_140042_15 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.000000000000000000000005576 102.0
HKD2_k127_140042_2 Beta-lactamase - - - 1.351e-201 636.0
HKD2_k127_140042_3 phosphate transporter K03306 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 563.0
HKD2_k127_140042_4 transport protein CorA K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004692 481.0
HKD2_k127_140042_5 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004041 409.0
HKD2_k127_140042_6 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009906 406.0
HKD2_k127_140042_7 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 337.0
HKD2_k127_140042_8 Participates in transcription elongation, termination and antitermination K02601 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 314.0
HKD2_k127_140042_9 cation diffusion facilitator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 305.0
HKD2_k127_140437_0 homoserine dehydrogenase K00003 - 1.1.1.3 2.713e-214 675.0
HKD2_k127_140437_1 in Escherichia coli this protein forms a dimer and binds manganese K11532 - 3.1.3.11,3.1.3.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003783 574.0
HKD2_k127_140437_2 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008428 562.0
HKD2_k127_140437_3 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006951 440.0
HKD2_k127_140437_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008708 275.0
HKD2_k127_140437_5 Thioesterase superfamily K07107 - - 0.000000000000000000000000000000000000000388 153.0
HKD2_k127_140437_6 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000000000000000000000000000000002146 139.0
HKD2_k127_140437_7 Periplasmic protein TonB, links inner and outer membranes K03832 - - 0.0000000003942 60.0
HKD2_k127_1456869_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.0 1175.0
HKD2_k127_1456869_1 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 2.113e-311 959.0
HKD2_k127_1456869_10 Catalytic LigB subunit of aromatic ring-opening dioxygenase K04101 - 1.13.11.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 444.0
HKD2_k127_1456869_11 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 432.0
HKD2_k127_1456869_12 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 426.0
HKD2_k127_1456869_13 CRP FNR family K01420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002151 374.0
HKD2_k127_1456869_14 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000168 347.0
HKD2_k127_1456869_15 OmpW family K07275 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 288.0
HKD2_k127_1456869_16 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001471 249.0
HKD2_k127_1456869_17 Uroporphyrinogen-III synthase K01719 - 4.2.1.75 0.00000000000000000000000000000000000000000000000000000000000006255 231.0
HKD2_k127_1456869_18 helix_turn_helix, Lux Regulon K14987 - - 0.000000000000000000000000000000000000000000000000000000001265 207.0
HKD2_k127_1456869_19 Aromatic-ring-opening dioxygenase LigAB, LigA subunit K04100 - 1.13.11.8 0.00000000000000000000000000000000000000000000001151 177.0
HKD2_k127_1456869_2 P-type ATPase K01533 - 3.6.3.4 2.914e-295 924.0
HKD2_k127_1456869_20 Integral membrane protein linked to a cation - - - 0.000000000000000000000000000000000000000000003397 169.0
HKD2_k127_1456869_21 Cbb3-type cytochrome oxidase component FixQ K00407 - - 0.0000000000000000003826 90.0
HKD2_k127_1456869_22 Cytochrome oxidase maturation protein cbb3-type - - - 0.00000000000004896 78.0
HKD2_k127_1456869_3 Thiol disulfide interchange protein - - - 1.3e-250 792.0
HKD2_k127_1456869_4 Nitrogen fixation protein fixG - - - 1.885e-243 758.0
HKD2_k127_1456869_5 Alkaline phosphatase with broad substrate specificity - - - 1.17e-199 639.0
HKD2_k127_1456869_6 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family K03185 - - 1.407e-197 625.0
HKD2_k127_1456869_7 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 591.0
HKD2_k127_1456869_8 acetyl-coa acetyltransferase K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001605 566.0
HKD2_k127_1456869_9 Peptidase S41 K00405 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 448.0
HKD2_k127_1570997_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 4.213e-262 809.0
HKD2_k127_1570997_1 Transport of potassium into the cell K03549 - - 8.513e-257 808.0
HKD2_k127_1570997_2 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005493 542.0
HKD2_k127_1570997_3 beta-lactamase K17836 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009041 365.0
HKD2_k127_1570997_4 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007748 281.0
HKD2_k127_1570997_5 COG2346 Truncated hemoglobins K06886 - - 0.00000000000000000000000000000000000000000000000004099 183.0
HKD2_k127_1570997_6 Transcriptional regulator K13771 - - 0.0000000000000000000000000000000000000000003533 162.0
HKD2_k127_1570997_7 - - - - 0.000000000000000000008013 98.0
HKD2_k127_1570997_8 Domain of unknown function (DUF1971) K06886 - - 0.0000000002552 70.0
HKD2_k127_1610979_0 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain K12541 - - 9.62e-321 995.0
HKD2_k127_1610979_1 Outer membrane efflux protein K12543 - - 1.35e-218 686.0
HKD2_k127_1610979_2 type I secretion membrane fusion protein K12542 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 524.0
HKD2_k127_1610979_3 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005867 505.0
HKD2_k127_1610979_4 Cell Wall Hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 355.0
HKD2_k127_1610979_5 OmpA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001033 241.0
HKD2_k127_1610979_6 calcium- and calmodulin-responsive adenylate cyclase activity K01406,K20276 - 3.4.24.40 0.00000000000000000000000000000000000000000006141 184.0
HKD2_k127_1636821_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1523.0
HKD2_k127_1636821_1 Peptidase, M16 - - - 0.0 1301.0
HKD2_k127_1636821_2 COG2366 Protein related to penicillin acylase K07116 - 3.5.1.97 1.786e-285 895.0
HKD2_k127_1636821_3 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 2.401e-279 868.0
HKD2_k127_1636821_4 TonB dependent receptor - - - 1.994e-237 743.0
HKD2_k127_1636821_5 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 462.0
HKD2_k127_1636821_6 Prolyl 4-hydroxylase alpha subunit homologues. K00472 - 1.14.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002209 388.0
HKD2_k127_1636821_7 - - - - 0.0000000000000000000000000000000000000000004763 159.0
HKD2_k127_1668168_0 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 4.705e-245 762.0
HKD2_k127_1668168_1 Glycosyl transferase - - - 1.271e-201 632.0
HKD2_k127_1668168_2 DNA mediated transformation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002221 620.0
HKD2_k127_1668168_3 GTP-binding protein TypA K06207 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 578.0
HKD2_k127_1668168_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000639 428.0
HKD2_k127_1668168_5 - - - - 0.00000000000000000000000000001172 128.0
HKD2_k127_167902_0 GTP-binding protein TypA K06207 - - 0.0 1051.0
HKD2_k127_167902_1 ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component K02004 - - 0.0 1046.0
HKD2_k127_167902_10 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000817 418.0
HKD2_k127_167902_11 Trehalose utilisation K09992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006397 394.0
HKD2_k127_167902_12 Trehalose utilisation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007647 357.0
HKD2_k127_167902_13 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 353.0
HKD2_k127_167902_14 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003638 349.0
HKD2_k127_167902_15 ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008525 344.0
HKD2_k127_167902_16 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006389 300.0
HKD2_k127_167902_17 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001933 302.0
HKD2_k127_167902_18 COG2755 Lysophospholipase L1 and related esterases K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000001011 263.0
HKD2_k127_167902_19 Retinal pigment epithelial membrane protein K11159 - - 0.0000000000000000000000000000000000000000000000000000000000000000001699 231.0
HKD2_k127_167902_2 Molydopterin dinucleotide binding domain - - - 0.0 1024.0
HKD2_k127_167902_20 Protein of unknown function (DUF805) - - - 0.0000000000000000000000000000000000000000000000000000001192 199.0
HKD2_k127_167902_21 DUF35 OB-fold domain, acyl-CoA-associated - - - 0.0000000000000000000000000000000000000000000001218 172.0
HKD2_k127_167902_22 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000007454 169.0
HKD2_k127_167902_23 PspC domain K03973 - - 0.00000000000008596 78.0
HKD2_k127_167902_24 - - - - 0.00000002635 55.0
HKD2_k127_167902_3 TonB dependent receptor - - - 1.193e-306 967.0
HKD2_k127_167902_4 TonB-dependent receptor K02014 - - 3.679e-223 719.0
HKD2_k127_167902_5 Acetyl-CoA acetyltransferase - - - 5.163e-198 625.0
HKD2_k127_167902_6 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001652 601.0
HKD2_k127_167902_7 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 503.0
HKD2_k127_167902_8 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003792 492.0
HKD2_k127_167902_9 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 482.0
HKD2_k127_1680270_0 zinc finger K00179 - 1.2.7.8 0.0 1016.0
HKD2_k127_1680270_1 Involved in the incorporation of exogenous aryl acids in the biosynthesis of aromatic amino acids catalysis of the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 487.0
HKD2_k127_1680270_2 Metal-dependent hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 318.0
HKD2_k127_1680270_3 P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006046 299.0
HKD2_k127_1729110_0 helicase K17675 - 3.6.4.13 0.0 1099.0
HKD2_k127_1729110_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 2.122e-270 851.0
HKD2_k127_1729110_2 Belongs to the ALAD family K01698 - 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 591.0
HKD2_k127_1729110_3 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005109 572.0
HKD2_k127_1729110_4 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002428 265.0
HKD2_k127_1729110_5 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.000000000000000000000000000000000000000000000000001801 184.0
HKD2_k127_1729110_6 S4 RNA-binding domain K04762 - - 0.0000000000000000000000000000001343 133.0
HKD2_k127_1759675_0 Belongs to the UPF0276 family K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007064 389.0
HKD2_k127_1759675_1 Protein of unknown function (DUF1109) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005568 283.0
HKD2_k127_1759675_2 Sigma-70 region 2 K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000887 278.0
HKD2_k127_1759675_3 DoxX K15977 - - 0.0000000000000000000000000000000000000000000000000000000000000003993 222.0
HKD2_k127_1759675_4 Putative DNA-binding domain - - - 0.000000000000000000000000000000000000000000005619 168.0
HKD2_k127_1759675_5 - - - - 0.0000000000000000000000000001806 117.0
HKD2_k127_1811135_0 ATPase with chaperone activity K07391 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004552 428.0
HKD2_k127_1811135_1 domain, Protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 376.0
HKD2_k127_1811135_2 COG1309 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000001458 241.0
HKD2_k127_1811135_3 transcriptional - - - 0.000000000000000000000000000000000000000000000000000000000000000004572 231.0
HKD2_k127_181611_0 PEP-utilising enzyme, mobile domain K01007 - 2.7.9.2 4.999e-307 949.0
HKD2_k127_181611_1 receptor K02014 - - 4.821e-283 884.0
HKD2_k127_181611_10 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000007212 168.0
HKD2_k127_181611_11 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000000000001798 156.0
HKD2_k127_181611_12 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0000000000000000000000000004708 128.0
HKD2_k127_181611_13 - - - - 0.000000000000000000000000008408 112.0
HKD2_k127_181611_15 transferase activity, transferring glycosyl groups - - - 0.00000152 50.0
HKD2_k127_181611_2 AMP-binding enzyme C-terminal domain - - - 1.035e-265 825.0
HKD2_k127_181611_3 Conserved carboxylase domain K01571 - 4.1.1.3 5.807e-235 746.0
HKD2_k127_181611_4 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00121 - 1.1.1.1,1.1.1.284 2.778e-223 696.0
HKD2_k127_181611_5 An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism K01961 - 6.3.4.14,6.4.1.2 3.668e-203 644.0
HKD2_k127_181611_6 RNB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 596.0
HKD2_k127_181611_7 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 462.0
HKD2_k127_181611_8 Glutathione S-transferase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005522 457.0
HKD2_k127_181611_9 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009925 396.0
HKD2_k127_1832997_0 Peptidase M48 - - - 1.936e-200 632.0
HKD2_k127_1832997_1 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001747 603.0
HKD2_k127_1832997_2 Response regulator of the LytR AlgR family K02477 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 486.0
HKD2_k127_1832997_3 Carboxylesterase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 322.0
HKD2_k127_1832997_4 Protein-disulfide isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001667 269.0
HKD2_k127_1832997_5 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000002093 127.0
HKD2_k127_1832997_6 Belongs to the NadC ModD family K00767 - 2.4.2.19 0.000000000000000001225 98.0
HKD2_k127_1868864_0 Protein of unknown function (DUF1173) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 375.0
HKD2_k127_1868864_1 Belongs to the 'phage' integrase family - - - 0.0000000000000000000000000000000000000000000000000004561 198.0
HKD2_k127_1868864_2 RES - - - 0.00000000000000000000000000000000000000000002077 169.0
HKD2_k127_1868864_3 Phage integrase family K07358 GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0015074,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - 0.00000000000000000000000000000000000000000004858 166.0
HKD2_k127_1868864_4 Protein of unknown function (DUF2384) - - - 0.00000000000000000000000000000000002834 139.0
HKD2_k127_1868864_5 AAA domain - - - 0.0000000000000000000000004531 110.0
HKD2_k127_1868864_6 Chromatin associated protein KTI12 K07028 - - 0.00000000000002297 86.0
HKD2_k127_1878989_0 Carbamoyltransferase C-terminus - - - 5.301e-277 866.0
HKD2_k127_1878989_1 Belongs to the major facilitator superfamily - - - 8.795e-205 651.0
HKD2_k127_1878989_10 PFAM blue (type 1) copper domain protein - - - 0.000000000000000000000000000000005707 134.0
HKD2_k127_1878989_11 sequence-specific DNA binding - - - 0.000000000000001662 78.0
HKD2_k127_1878989_12 Redoxin K03386 - 1.11.1.15 0.00000000000001376 77.0
HKD2_k127_1878989_14 Sigma-70, region 4 - - - 0.0000000000003856 76.0
HKD2_k127_1878989_2 COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001389 509.0
HKD2_k127_1878989_3 Chalcone and stilbene synthases, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 504.0
HKD2_k127_1878989_4 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005705 446.0
HKD2_k127_1878989_5 Phenazine biosynthesis-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 374.0
HKD2_k127_1878989_6 FAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 355.0
HKD2_k127_1878989_7 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 305.0
HKD2_k127_1878989_8 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000000000000000000000000000000000000001399 210.0
HKD2_k127_1878989_9 Efflux protein - - - 0.000000000000000000000000000000000000000000001102 179.0
HKD2_k127_1902723_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1050.0
HKD2_k127_1902723_1 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916 - 6.3.1.5 1.183e-302 933.0
HKD2_k127_1902723_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.401e-225 716.0
HKD2_k127_1902723_3 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 389.0
HKD2_k127_1902723_4 3'-5' exonuclease K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001277 380.0
HKD2_k127_1902723_5 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine K03648 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001852 366.0
HKD2_k127_1902723_6 Protein conserved in bacteria K11719 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000318 268.0
HKD2_k127_1902723_7 - - - - 0.00000000000000000000000000000000000000000000004669 182.0
HKD2_k127_19201_0 DNA segregation ATPase FtsK SpoIIIE K03466 - - 0.0 1087.0
HKD2_k127_19201_1 Belongs to the 5'-nucleotidase family K01081 - 3.1.3.5 1.312e-208 663.0
HKD2_k127_19201_2 Protein of unknown function (DUF1295) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 400.0
HKD2_k127_19201_3 COG4240 Predicted kinase K15918 - 2.7.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 328.0
HKD2_k127_19201_4 Phosphate acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003263 280.0
HKD2_k127_19201_5 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001019 271.0
HKD2_k127_19201_6 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000001865 226.0
HKD2_k127_19201_7 Thiamine monophosphate synthase K00788 - 2.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000001863 227.0
HKD2_k127_2027586_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005809 404.0
HKD2_k127_2027586_1 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 295.0
HKD2_k127_2027586_2 Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - 0.0000000000000000000000000000000000000000000008447 169.0
HKD2_k127_2027586_3 Nucleotidyl transferase AbiEii toxin, Type IV TA system K09144 - - 0.000000000000000000000000000000000397 138.0
HKD2_k127_2027586_5 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.00000000000000000001494 102.0
HKD2_k127_2027586_6 Prophage CP4-57 regulatory protein (AlpA) K07733 - - 0.000001979 49.0
HKD2_k127_216717_0 Glycosyl hydrolase 36 superfamily, catalytic domain K13688 - - 0.0 2775.0
HKD2_k127_216717_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 1.097e-286 889.0
HKD2_k127_216717_10 Uncharacterized protein conserved in bacteria (DUF2236) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 481.0
HKD2_k127_216717_11 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 450.0
HKD2_k127_216717_12 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 417.0
HKD2_k127_216717_13 Short-chain dehydrogenase reductase sdr - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004611 377.0
HKD2_k127_216717_14 MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 334.0
HKD2_k127_216717_15 Short-chain dehydrogenase reductase sdr - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001057 329.0
HKD2_k127_216717_16 molecular chaperone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 315.0
HKD2_k127_216717_17 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006476 303.0
HKD2_k127_216717_18 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007769 314.0
HKD2_k127_216717_19 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003188 273.0
HKD2_k127_216717_2 Flavin-binding monooxygenase-like - - - 6.365e-284 889.0
HKD2_k127_216717_20 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004434 250.0
HKD2_k127_216717_21 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000004843 247.0
HKD2_k127_216717_22 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000001028 229.0
HKD2_k127_216717_23 thioesterase K07107 - - 0.0000000000000000000000000000000000000000000000000000000000000658 216.0
HKD2_k127_216717_24 Biopolymer transport protein K03560 - - 0.000000000000000000000000000000000000000000000000000000001908 203.0
HKD2_k127_216717_25 Transcriptional regulator, TetR, C-terminal - - - 0.0000000000000000000000000000000000000000000000000005012 191.0
HKD2_k127_216717_26 BON domain - - - 0.00000000000000000000000000000000000000000000008214 182.0
HKD2_k127_216717_27 Belongs to the universal stress protein A family - - - 0.00000000000000000000000000000000002699 149.0
HKD2_k127_216717_28 Phosphoribosyl-ATP K01523 - 3.6.1.31 0.0000000000000000000000000000000002247 133.0
HKD2_k127_216717_29 Aminoglycoside phosphotransferase - - - 0.00000000004639 70.0
HKD2_k127_216717_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 9.972e-279 867.0
HKD2_k127_216717_4 receptor - - - 2.55e-276 872.0
HKD2_k127_216717_5 Involved in the TonB-independent uptake of proteins K03641 - - 5.571e-234 734.0
HKD2_k127_216717_6 Belongs to the enoyl-CoA hydratase isomerase family K07516 - 1.1.1.35 1.187e-223 698.0
HKD2_k127_216717_7 Acyl-CoA dehydrogenase, middle domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 602.0
HKD2_k127_216717_8 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008208 571.0
HKD2_k127_216717_9 acyl-CoA dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 563.0
HKD2_k127_221827_0 Flp pilus assembly protein, ATPase CpaF K02283 - - 4.714e-292 901.0
HKD2_k127_221827_1 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007769 414.0
HKD2_k127_221827_2 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 320.0
HKD2_k127_221827_3 of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005314 317.0
HKD2_k127_221827_4 Proline racemase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000977 280.0
HKD2_k127_221827_5 Uncharacterized conserved protein (DUF2278) - - - 0.0000000000000000000000000000000000000000000001615 175.0
HKD2_k127_221827_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.00000000000000000000000000000000000000000005226 160.0
HKD2_k127_221827_7 Produces ATP from ADP in the presence of a proton gradient across the membrane K02113,K02114 - - 0.0000000000000000000000000000000000000008453 148.0
HKD2_k127_221827_8 Domain of unknown function (DU1801) - - - 0.000000000000000000000000000000000000004264 149.0
HKD2_k127_221827_9 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000005761 130.0
HKD2_k127_2319285_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1871.0
HKD2_k127_2319285_1 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000529 502.0
HKD2_k127_2319285_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 376.0
HKD2_k127_2319285_3 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 365.0
HKD2_k127_2319285_4 O-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001131 271.0
HKD2_k127_2337296_0 Aminomethyltransferase folate-binding domain K15064 - - 1.358e-251 782.0
HKD2_k127_2337296_1 Methionine synthase K00549 - 2.1.1.14 8.958e-225 699.0
HKD2_k127_2337296_10 Bacterial transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007343 277.0
HKD2_k127_2337296_11 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000126 272.0
HKD2_k127_2337296_12 Nudix hydrolase K01515 - 3.6.1.13 0.000000000000000000000000000000000000000000000000000000000000000000009731 252.0
HKD2_k127_2337296_13 DIM6 NTAB family - - - 0.000000000000000000000000000000000000000000000000000000000000000001057 231.0
HKD2_k127_2337296_14 Nuclear transport factor 2 (NTF2) domain - - - 0.00000000000000000000000000000000000000000000000000000000174 203.0
HKD2_k127_2337296_15 Belongs to the TPP enzyme family K01576 - 4.1.1.7 0.00000000000000000000000000000000000000000000000000000001055 201.0
HKD2_k127_2337296_16 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.000000000000000000000000000000000000000000009043 167.0
HKD2_k127_2337296_2 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003858 599.0
HKD2_k127_2337296_3 Transposase and inactivated derivatives K07486 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009058 469.0
HKD2_k127_2337296_4 helix_turn _helix lactose operon repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 453.0
HKD2_k127_2337296_5 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 443.0
HKD2_k127_2337296_6 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008662 410.0
HKD2_k127_2337296_7 Methanol dehydrogenase K06872 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 308.0
HKD2_k127_2337296_8 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005691 302.0
HKD2_k127_2337296_9 membrane K08988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 289.0
HKD2_k127_2556247_0 Glutathione S-transferase, C-terminal domain K11209 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004519 449.0
HKD2_k127_2556247_1 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000323 334.0
HKD2_k127_2556247_2 Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process K05797 - 1.17.99.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 304.0
HKD2_k127_2556247_3 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006891 256.0
HKD2_k127_2556247_4 Cytochrome c K00406 - - 0.00000000000000000000000000000000000000000000003871 178.0
HKD2_k127_2556247_6 AMP-binding enzyme C-terminal domain - - - 0.000000000002803 71.0
HKD2_k127_2563797_0 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 2.863e-275 856.0
HKD2_k127_2563797_1 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 7.324e-255 795.0
HKD2_k127_2563797_10 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000144 342.0
HKD2_k127_2563797_11 Belongs to the ribose-phosphate pyrophosphokinase family K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008734 330.0
HKD2_k127_2563797_12 periplasmic protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000009887 252.0
HKD2_k127_2563797_13 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002906 253.0
HKD2_k127_2563797_14 dioxygenase of extradiol dioxygenase family K06991 - - 0.00000000000000000000000000000000000000000000000000000000000000003051 225.0
HKD2_k127_2563797_15 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.00000000000000000000000000000000000000000000000002307 184.0
HKD2_k127_2563797_16 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000000000000000000000005518 147.0
HKD2_k127_2563797_17 Binds directly to 16S ribosomal RNA K02968 - - 0.00000000000000000000000000000000000002554 144.0
HKD2_k127_2563797_18 - - - - 0.0000000000000000000000000000000002202 138.0
HKD2_k127_2563797_19 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.00000000000000005249 82.0
HKD2_k127_2563797_2 thymidine phosphorylase K00758 - 2.4.2.4 1.123e-250 780.0
HKD2_k127_2563797_20 ATPase with chaperone activity K07391 - - 0.00000000008652 64.0
HKD2_k127_2563797_3 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 1.193e-209 661.0
HKD2_k127_2563797_4 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 1.824e-196 617.0
HKD2_k127_2563797_5 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005328 409.0
HKD2_k127_2563797_6 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 393.0
HKD2_k127_2563797_7 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004217 389.0
HKD2_k127_2563797_8 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007924 372.0
HKD2_k127_2563797_9 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003183 367.0
HKD2_k127_2581768_0 Aminomethyltransferase folate-binding domain K15066 - 2.1.1.341 3.732e-275 847.0
HKD2_k127_2581768_1 Belongs to the aspartokinase family K00928 - 2.7.2.4 2.19e-231 726.0
HKD2_k127_2581768_10 nicotinamide mononucleotide transporter K03811 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 291.0
HKD2_k127_2581768_11 import inner membrane translocase, subunit Tim44 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003214 280.0
HKD2_k127_2581768_12 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001698 248.0
HKD2_k127_2581768_13 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000003698 231.0
HKD2_k127_2581768_14 Belongs to the ArsC family - - - 0.000000000000000000000000000000000000000000000000000004806 191.0
HKD2_k127_2581768_15 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000405 183.0
HKD2_k127_2581768_16 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000000000000000002888 156.0
HKD2_k127_2581768_2 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 1.827e-200 639.0
HKD2_k127_2581768_3 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 3.217e-200 631.0
HKD2_k127_2581768_4 2-nitropropane dioxygenase K02371 - 1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007505 586.0
HKD2_k127_2581768_5 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 579.0
HKD2_k127_2581768_6 membrane-bound lytic murein transglycosylase K08304 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003896 574.0
HKD2_k127_2581768_7 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004875 495.0
HKD2_k127_2581768_8 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 372.0
HKD2_k127_2581768_9 Alpha/beta hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 305.0
HKD2_k127_2582516_0 FAD linked - - - 8.362e-230 719.0
HKD2_k127_2582516_1 PFAM SapC family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 377.0
HKD2_k127_2582516_2 - - - - 0.0000000000000000000000000000000000000003122 156.0
HKD2_k127_2582516_3 Belongs to the DEAD box helicase family - - - 0.00000001842 56.0
HKD2_k127_259890_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1693.0
HKD2_k127_259890_1 Pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 8.944e-242 751.0
HKD2_k127_259890_2 Sulfotransferase domain K01014 - 2.8.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 486.0
HKD2_k127_259890_3 Outer membrane efflux protein K12340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 442.0
HKD2_k127_259890_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009288 365.0
HKD2_k127_259890_5 Bacterial transglutaminase-like cysteine proteinase BTLCP - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002479 255.0
HKD2_k127_259890_6 Rhodanese-like domain - - - 0.0000000000000000000000000000000000000129 149.0
HKD2_k127_259890_7 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000005907 142.0
HKD2_k127_259890_8 Protein of unknown function (DUF2892) - - - 0.0000000000000000000000007173 104.0
HKD2_k127_2603405_0 Aminotransferase K14261 - - 7.911e-243 752.0
HKD2_k127_2603405_1 poly(R)-hydroxyalkanoic acid synthase K03821 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000254 602.0
HKD2_k127_2603405_2 COG0075 serine-pyruvate aminotransferase archaeal aspartate aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009675 590.0
HKD2_k127_2603405_3 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000339 456.0
HKD2_k127_2603405_4 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 361.0
HKD2_k127_2603405_5 Putative zinc-finger - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004091 274.0
HKD2_k127_2603405_6 Sigma-70, region 4 - - - 0.00000000000000000000000000000000000000000000000000001623 194.0
HKD2_k127_2603405_7 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000004342 175.0
HKD2_k127_2603405_8 Cytochrome c - - - 0.0000000000000000000000000000000000000000000005177 184.0
HKD2_k127_2603405_9 NADH-dependant formate dehydrogenase delta subunit FdsD K00126 - 1.17.1.9 0.0000000000000000009505 92.0
HKD2_k127_2604184_0 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 491.0
HKD2_k127_2604184_1 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 379.0
HKD2_k127_2604184_2 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000000000000000000000000000000001892 198.0
HKD2_k127_2604184_3 membrane - - - 0.000000000000000000000000000000000000000000003763 169.0
HKD2_k127_2614774_0 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 1.018e-254 787.0
HKD2_k127_2614774_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 5.722e-251 781.0
HKD2_k127_2614774_10 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005063 295.0
HKD2_k127_2614774_11 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009654 271.0
HKD2_k127_2614774_12 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002816 252.0
HKD2_k127_2614774_13 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000000000000000000000000000000000000000000000000000000003278 235.0
HKD2_k127_2614774_14 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.0000000000000000000000000000000000000000000000000000000000000002555 223.0
HKD2_k127_2614774_15 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000000000000000000000000000000000000000000000002128 222.0
HKD2_k127_2614774_16 Helix-turn-helix domain - - - 0.0000000000000000000000000000000000000000000000000000000005217 209.0
HKD2_k127_2614774_17 Protein of unknown function (FYDLN_acid) - - - 0.000000000000000000000000000000000000000000000000001718 184.0
HKD2_k127_2614774_18 Protein of unknown function (DUF1153) - - - 0.0000000000000000000000000000000000000004239 151.0
HKD2_k127_2614774_19 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000000000000000000005873 145.0
HKD2_k127_2614774_2 UDP-N-acetylmuramate-alanine ligase K01924 - 6.3.2.8 2.33e-237 741.0
HKD2_k127_2614774_20 Cupin domain - - - 0.000000000000000000000000000000000000451 144.0
HKD2_k127_2614774_21 Cytochrome c - - - 0.000000000000000000001088 99.0
HKD2_k127_2614774_22 - - - - 0.0000000000000000000416 97.0
HKD2_k127_2614774_23 Helix-turn-helix domain - - - 0.000000000000001362 85.0
HKD2_k127_2614774_3 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 7.253e-225 705.0
HKD2_k127_2614774_4 Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations K01241 - 3.2.2.4 6.811e-218 686.0
HKD2_k127_2614774_5 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 2.878e-202 639.0
HKD2_k127_2614774_6 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 445.0
HKD2_k127_2614774_7 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 347.0
HKD2_k127_2614774_8 Binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001187 313.0
HKD2_k127_2614774_9 Diguanylate cyclase, GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 319.0
HKD2_k127_2624836_0 cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005752 515.0
HKD2_k127_2624836_1 Transcriptional regulator K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005904 408.0
HKD2_k127_2624836_2 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 364.0
HKD2_k127_2624836_3 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 - 2.5.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 338.0
HKD2_k127_2624836_4 but high domain identity with epimerases and phenazine biosynthesis-like protein, PhzC PhzF which is involved in dimerisation of two 2,3- dihydro-3-oxo-anthranilic acid molecules to create Pca by P. fluorescens K06998 - 5.3.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003391 299.0
HKD2_k127_2624836_5 protein affecting Mg2 Co2 transport K06195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006448 241.0
HKD2_k127_2624836_6 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000001255 123.0
HKD2_k127_2624836_7 BetI-type transcriptional repressor, C-terminal - - - 0.000000000000000000000006497 109.0
HKD2_k127_2624836_8 rubredoxin - - - 0.0000000000000000000001897 97.0
HKD2_k127_2631379_0 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006967 424.0
HKD2_k127_2631379_1 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005092 374.0
HKD2_k127_2631379_2 Binds to the 23S rRNA K02876 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008563 251.0
HKD2_k127_2631379_3 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.0000000000000000000000000000000000000000000000000000000006434 214.0
HKD2_k127_2631379_4 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000000000001428 191.0
HKD2_k127_2631379_5 Ribosomal protein L30 K02907 - - 0.0000000000000000000000003681 105.0
HKD2_k127_2647079_0 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007962 409.0
HKD2_k127_2647079_1 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000958 248.0
HKD2_k127_2647079_2 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000005464 216.0
HKD2_k127_2647079_3 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000002484 196.0
HKD2_k127_2647079_4 relative of glutathione S-transferase, MAPEG superfamily K07136 - - 0.00000000000000000000000000000000003686 136.0
HKD2_k127_2647079_5 - - - - 0.000000000000000000000000000000006647 131.0
HKD2_k127_2694564_0 dihydropteroate synthase K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007457 418.0
HKD2_k127_2694564_1 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 357.0
HKD2_k127_2694564_2 Protein of unknown function (DUF3999) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008671 281.0
HKD2_k127_2797863_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 1.374e-299 934.0
HKD2_k127_2797863_1 Oxidizes proline to glutamate for use as a carbon and nitrogen source K13821 - 1.2.1.88,1.5.5.2 7.984e-276 863.0
HKD2_k127_2797863_2 COG3209 Rhs family protein - - - 7.356e-255 824.0
HKD2_k127_2859061_0 COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01966 - 2.1.3.15,6.4.1.3 2.313e-279 863.0
HKD2_k127_2859061_1 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 5.192e-214 676.0
HKD2_k127_2859061_2 acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 5.637e-207 653.0
HKD2_k127_2859061_3 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 543.0
HKD2_k127_2859061_4 Major facilitator superfamily K07552 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 516.0
HKD2_k127_2859061_5 6-phosphogluconolactonase K01057 - 3.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 289.0
HKD2_k127_2859061_6 GDP-mannose mannosyl hydrolase activity - - - 0.000000000000000000000000000000000153 143.0
HKD2_k127_2924650_0 of ABC transporters with duplicated ATPase K15738 - - 7.022e-319 985.0
HKD2_k127_2924650_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 6.567e-257 800.0
HKD2_k127_2924650_10 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.00000000000000000000000000000000000000000000000000000000000000000009566 233.0
HKD2_k127_2924650_11 Holin of 3TMs, for gene-transfer release - - - 0.00000000000000000000000000000000000000000000000000000000005329 209.0
HKD2_k127_2924650_12 Preprotein translocase subunit YajC K03210 - - 0.0000000000000000000000000000000000000000001991 161.0
HKD2_k127_2924650_13 - - - - 0.000000000000000000000000000000002448 132.0
HKD2_k127_2924650_14 hydrolase K01048 - 3.1.1.5 0.0006817 46.0
HKD2_k127_2924650_2 protein conserved in bacteria - - - 6.524e-234 739.0
HKD2_k127_2924650_3 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003553 495.0
HKD2_k127_2924650_4 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000617 471.0
HKD2_k127_2924650_5 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005807 437.0
HKD2_k127_2924650_6 XRE family transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004408 273.0
HKD2_k127_2924650_7 D-amino acid aminotransferase K00824 - 2.6.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000003546 272.0
HKD2_k127_2924650_8 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001773 255.0
HKD2_k127_2924650_9 DNA-binding transcription factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000002402 236.0
HKD2_k127_299234_0 single-stranded-DNA-specific exonuclease RecJ K07462 - - 3.278e-314 970.0
HKD2_k127_299234_1 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 552.0
HKD2_k127_299234_10 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000005811 137.0
HKD2_k127_299234_11 - - - - 0.0000000000000000000000116 108.0
HKD2_k127_299234_2 alcohol dehydrogenase K13954 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 554.0
HKD2_k127_299234_3 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002306 532.0
HKD2_k127_299234_4 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 490.0
HKD2_k127_299234_5 MOSC domain - - - 0.000000000000000000000000000000000000000000000000000000000000000009125 229.0
HKD2_k127_299234_6 COG0655 Multimeric flavodoxin WrbA - - - 0.00000000000000000000000000000000000000000000000000000000000001717 220.0
HKD2_k127_299234_7 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000000000003563 199.0
HKD2_k127_299234_8 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH - - - 0.0000000000000000000000000000000000000000000000000000006841 198.0
HKD2_k127_299234_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000008065 207.0
HKD2_k127_3131454_0 signal peptide peptidase K04773 - - 4.119e-236 747.0
HKD2_k127_3131454_1 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 7.413e-232 728.0
HKD2_k127_3131454_2 dihydroorotase K01465 - 3.5.2.3 4.445e-196 623.0
HKD2_k127_3131454_3 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000021 528.0
HKD2_k127_3131454_4 Transposase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 430.0
HKD2_k127_3131454_5 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 404.0
HKD2_k127_3131454_6 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 364.0
HKD2_k127_3131454_7 Sporulation related domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005425 331.0
HKD2_k127_3131454_8 - - - - 0.0000000000000000000000000000000006199 135.0
HKD2_k127_3131454_9 - - - - 0.0000000004199 61.0
HKD2_k127_3231133_0 Carboxypeptidase - - - 1.009e-195 616.0
HKD2_k127_3231133_1 Glycosyl hydrolases family 25 K07273 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 338.0
HKD2_k127_3231133_2 alpha/beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000001746 197.0
HKD2_k127_3231133_3 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.00000000000000000000000000000000000000000000000001084 196.0
HKD2_k127_3231133_4 Belongs to the UPF0262 family - - - 0.0000000000001452 70.0
HKD2_k127_3465298_0 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 1.582e-304 939.0
HKD2_k127_3465298_1 Dehydrogenase K00124,K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002942 553.0
HKD2_k127_3465298_2 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000001104 246.0
HKD2_k127_3470885_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1532.0
HKD2_k127_3470885_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002944 570.0
HKD2_k127_3470885_10 Belongs to the CinA family K03743 - 3.5.1.42 0.000000000000000000000000000000000002883 146.0
HKD2_k127_3470885_11 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K07712 - - 0.00000005215 58.0
HKD2_k127_3470885_2 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000739 558.0
HKD2_k127_3470885_3 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009852 521.0
HKD2_k127_3470885_4 Histidine kinase K07708 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003381 462.0
HKD2_k127_3470885_5 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008073 390.0
HKD2_k127_3470885_6 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 359.0
HKD2_k127_3470885_7 taurine catabolism dioxygenase K03119 - 1.14.11.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 302.0
HKD2_k127_3470885_8 Oligoketide cyclase lipid transport protein K18588 - - 0.000000000000000000000000000000000000000000000000000000000000000000001214 241.0
HKD2_k127_3470885_9 - - - - 0.0000000000000000000000000000000000000004897 154.0
HKD2_k127_3481319_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1579.0
HKD2_k127_3481319_1 Domain of unknown function DUF87 K06915 - - 8.117e-310 956.0
HKD2_k127_3481319_10 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 384.0
HKD2_k127_3481319_11 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005828 368.0
HKD2_k127_3481319_12 Putative transmembrane protein (Alph_Pro_TM) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009193 370.0
HKD2_k127_3481319_13 Bacterial protein of unknown function (Gcw_chp) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008089 326.0
HKD2_k127_3481319_14 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases K07313 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 310.0
HKD2_k127_3481319_15 Putative FMN-binding domain K07734 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 312.0
HKD2_k127_3481319_16 Chaperone required for the assembly of the mitochondrial F1-ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000712 291.0
HKD2_k127_3481319_17 COG0346 Lactoylglutathione lyase and related lyases K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001993 270.0
HKD2_k127_3481319_18 Hydrolase K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000005796 267.0
HKD2_k127_3481319_19 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005075 258.0
HKD2_k127_3481319_2 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 3.953e-236 735.0
HKD2_k127_3481319_20 ABC-type transport auxiliary lipoprotein component - - - 0.0000000000000000000000000000000000000000000000000000003336 203.0
HKD2_k127_3481319_21 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000000000000000000000139 172.0
HKD2_k127_3481319_22 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000001932 146.0
HKD2_k127_3481319_23 COG1215 Glycosyltransferases, probably involved in cell wall biogenesis K11740 - - 0.000000000006072 68.0
HKD2_k127_3481319_24 - - - - 0.0000000002066 65.0
HKD2_k127_3481319_3 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009314 608.0
HKD2_k127_3481319_4 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005937 526.0
HKD2_k127_3481319_5 Na -driven multidrug efflux pump - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006721 497.0
HKD2_k127_3481319_6 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007456 482.0
HKD2_k127_3481319_7 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005773 479.0
HKD2_k127_3481319_8 ABC-type transport system involved in resistance to organic solvents, periplasmic component K02067 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004436 445.0
HKD2_k127_3481319_9 ABC-type transport system involved in resistance to organic solvents, ATPase component K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001236 437.0
HKD2_k127_352139_0 Participates in both transcription termination and antitermination K02600 - - 4.65e-304 938.0
HKD2_k127_352139_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 1.054e-279 863.0
HKD2_k127_352139_10 PspC domain K03973 - - 0.000000000000000000000000000000000000000000000000000005316 193.0
HKD2_k127_352139_11 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.0000000000000000000000000000000000000000000000000004078 186.0
HKD2_k127_352139_12 Domain of unknown function (DUF1476) - - - 0.00000000000000000000000000000000000000000004104 163.0
HKD2_k127_352139_13 Phage shock protein B K03970 - - 0.0000000000000000000000000000000000000000002486 159.0
HKD2_k127_352139_14 Belongs to the BolA IbaG family - - - 0.000000000000000000000000000000000008385 136.0
HKD2_k127_352139_15 - - - - 0.000000000000000000000000000000006036 130.0
HKD2_k127_352139_16 - - - - 0.0000000000000000000004906 97.0
HKD2_k127_352139_17 - - - - 0.0000000000000000006117 92.0
HKD2_k127_352139_18 - - - - 0.0000000000008214 71.0
HKD2_k127_352139_19 - - - - 0.0000000002319 65.0
HKD2_k127_352139_2 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain K03974 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001515 587.0
HKD2_k127_352139_21 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000001854 57.0
HKD2_k127_352139_3 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004363 500.0
HKD2_k127_352139_4 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006455 448.0
HKD2_k127_352139_5 Phage shock protein A K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 384.0
HKD2_k127_352139_6 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005419 346.0
HKD2_k127_352139_7 Required for maturation of 30S ribosomal subunits K09748 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006024 316.0
HKD2_k127_352139_8 Nucleic-acid-binding protein K07742 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001046 276.0
HKD2_k127_352139_9 SufE protein probably involved in Fe-S center assembly K02426 - - 0.00000000000000000000000000000000000000000000000000000000000009276 221.0
HKD2_k127_3548395_0 Histidine kinase K13587 - 2.7.13.3 0.0 1149.0
HKD2_k127_3548395_1 Elongation factor G, domain IV K02355 - - 2.083e-275 859.0
HKD2_k127_3548395_10 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008349 278.0
HKD2_k127_3548395_11 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001554 274.0
HKD2_k127_3548395_12 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000005743 237.0
HKD2_k127_3548395_13 protein conserved in bacteria K09928 - - 0.0000000000000000000000000000000000000000000000000000000203 204.0
HKD2_k127_3548395_14 invasion associated locus B - - - 0.0000000000000000000000000000000000000000000000000000000754 202.0
HKD2_k127_3548395_15 protein conserved in bacteria K09928 - - 0.00000000000000000000000000000000000000000000000002425 188.0
HKD2_k127_3548395_16 Glycine zipper 2TM domain - - - 0.0000000000000000000000000000000000000000101 156.0
HKD2_k127_3548395_18 Domain of unknown function (DUF4169) - - - 0.0000003612 54.0
HKD2_k127_3548395_2 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 2.109e-243 755.0
HKD2_k127_3548395_3 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 4.088e-240 760.0
HKD2_k127_3548395_4 COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - 4.014e-215 687.0
HKD2_k127_3548395_5 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 9.373e-206 642.0
HKD2_k127_3548395_6 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005882 528.0
HKD2_k127_3548395_7 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004022 520.0
HKD2_k127_3548395_8 MatE K03327 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000994 503.0
HKD2_k127_3548395_9 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001587 324.0
HKD2_k127_371645_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 1.134e-218 685.0
HKD2_k127_371645_1 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 419.0
HKD2_k127_371645_2 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008722 401.0
HKD2_k127_371645_3 Peptidase family S41 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001165 258.0
HKD2_k127_371645_4 Lysin motif - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002737 250.0
HKD2_k127_371645_5 CHAP domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001126 236.0
HKD2_k127_371645_6 Protein of unknown function (DUF3297) - - - 0.0000000000000000000000000000000000000000000000001256 177.0
HKD2_k127_371645_7 Protein of unknown function (DUF1761) - - - 0.0000000000000000000000001577 111.0
HKD2_k127_371645_8 Protein of unknown function (DUF2892) - - - 0.000000000000000000000004576 103.0
HKD2_k127_371645_9 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000002369 57.0
HKD2_k127_3840788_0 Cell division protein FtsI penicillin-binding protein K03587 - 3.4.16.4 2.38e-282 876.0
HKD2_k127_3840788_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 3.396e-259 822.0
HKD2_k127_3840788_10 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 1.814e-196 616.0
HKD2_k127_3840788_11 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004953 591.0
HKD2_k127_3840788_12 Cell wall formation K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009314 574.0
HKD2_k127_3840788_13 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 509.0
HKD2_k127_3840788_14 Cell wall formation K00075 - 1.3.1.98 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000304 501.0
HKD2_k127_3840788_15 nitrilase K01501 - 3.5.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006613 487.0
HKD2_k127_3840788_16 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003427 483.0
HKD2_k127_3840788_17 highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 466.0
HKD2_k127_3840788_18 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003684 452.0
HKD2_k127_3840788_19 Cell division protein FtsQ K03589 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 408.0
HKD2_k127_3840788_2 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 1.629e-224 711.0
HKD2_k127_3840788_20 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003469 406.0
HKD2_k127_3840788_21 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007865 418.0
HKD2_k127_3840788_22 COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008062 347.0
HKD2_k127_3840788_23 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005543 329.0
HKD2_k127_3840788_24 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004254 326.0
HKD2_k127_3840788_25 Putative bacterial sensory transduction regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002582 293.0
HKD2_k127_3840788_26 Domain of unknown function (DUF4163) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000009648 255.0
HKD2_k127_3840788_27 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.0000000000000000000000000000000000000000000000000000000000000000000000001 268.0
HKD2_k127_3840788_28 Belongs to the MraZ family K03925 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002582 251.0
HKD2_k127_3840788_29 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002983 231.0
HKD2_k127_3840788_3 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 1.594e-218 687.0
HKD2_k127_3840788_30 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000000001193 208.0
HKD2_k127_3840788_31 - - - - 0.0000000000000000000000000000000000000000004901 170.0
HKD2_k127_3840788_32 NLP P60 protein - - - 0.0000000000000000000000000000000000000000825 158.0
HKD2_k127_3840788_33 pterin-4-alpha-carbinolamine dehydratase K01724 - 4.2.1.96 0.0000000000000000000000000000000000006565 141.0
HKD2_k127_3840788_34 - - - - 0.00000000000000000000971 95.0
HKD2_k127_3840788_35 Belongs to the BI1 family K06890 - - 0.000000151 52.0
HKD2_k127_3840788_4 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 1.219e-217 688.0
HKD2_k127_3840788_5 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 4.081e-215 693.0
HKD2_k127_3840788_6 Belongs to the peptidase M17 family K01255 - 3.4.11.1 1.633e-206 651.0
HKD2_k127_3840788_7 Cysteine synthase K01738 - 2.5.1.47 6.597e-202 631.0
HKD2_k127_3840788_8 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 7.902e-201 639.0
HKD2_k127_3840788_9 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 6.795e-197 619.0
HKD2_k127_3871027_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.0 1146.0
HKD2_k127_3871027_1 Belongs to the carbohydrate kinase PfkB family K16370 - 2.7.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 359.0
HKD2_k127_3871027_10 Helix-turn-helix XRE-family like proteins - - - 0.00004144 52.0
HKD2_k127_3871027_2 50S ribosomal protein L21 K09958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000755 262.0
HKD2_k127_3871027_3 - - - - 0.0000000000000000000000000000000000000000000000000000901 190.0
HKD2_k127_3871027_4 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000004545 181.0
HKD2_k127_3871027_5 Fic/DOC family K07341 - - 0.00000000000000000000000000000000000000000005361 167.0
HKD2_k127_3871027_6 - - - - 0.00000000000000000000000000000000000007005 148.0
HKD2_k127_3871027_7 SpoVT / AbrB like domain - - - 0.0000000000000000000000000000002748 124.0
HKD2_k127_3871027_8 Protein of unknown function (DUF3175) - - - 0.00000000000000000000000000006554 121.0
HKD2_k127_3871027_9 pyridoxamine 5-phosphate K07006 - - 0.000000000118 62.0
HKD2_k127_3881821_0 NADH ubiquinone oxidoreductase subunit K00341 - 1.6.5.3 0.0 1147.0
HKD2_k127_3881821_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.0 1002.0
HKD2_k127_3881821_10 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 574.0
HKD2_k127_3881821_11 membrane metal-binding protein K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 530.0
HKD2_k127_3881821_12 molybdopterin biosynthesis K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 509.0
HKD2_k127_3881821_13 alpha/beta hydrolase fold K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 481.0
HKD2_k127_3881821_14 Serine aminopeptidase, S33 K01259 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 453.0
HKD2_k127_3881821_15 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000724 439.0
HKD2_k127_3881821_16 Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002252 413.0
HKD2_k127_3881821_17 Belongs to the TrpC family K01609 - 4.1.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004645 408.0
HKD2_k127_3881821_18 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 - 2.4.2.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004399 393.0
HKD2_k127_3881821_19 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 377.0
HKD2_k127_3881821_2 NADH ubiquinone oxidoreductase subunit K00342 - 1.6.5.3 5.162e-278 860.0
HKD2_k127_3881821_20 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008581 366.0
HKD2_k127_3881821_21 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005947 342.0
HKD2_k127_3881821_22 with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001096 340.0
HKD2_k127_3881821_23 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 332.0
HKD2_k127_3881821_24 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 310.0
HKD2_k127_3881821_25 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001956 315.0
HKD2_k127_3881821_26 membrane metal-binding protein K02238 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002051 308.0
HKD2_k127_3881821_27 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009652 305.0
HKD2_k127_3881821_28 Belongs to the small heat shock protein (HSP20) family K04080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002557 248.0
HKD2_k127_3881821_29 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003268 252.0
HKD2_k127_3881821_3 metallo-beta-lactamase K12574 - - 2.658e-275 855.0
HKD2_k127_3881821_30 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000000000000000005519 220.0
HKD2_k127_3881821_31 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000006602 187.0
HKD2_k127_3881821_32 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.000000000000000000000000000000000000000000000007939 173.0
HKD2_k127_3881821_33 Preprotein translocase subunit SecG K03075 - - 0.000000000000000000000000000000000000002813 150.0
HKD2_k127_3881821_34 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.000000000000000000000000000000000001948 139.0
HKD2_k127_3881821_35 - - - - 0.00000000000000000000000000000000003363 143.0
HKD2_k127_3881821_36 Protein of unknown function (DUF1467) - - - 0.0000000000000000000000000000000002234 136.0
HKD2_k127_3881821_37 4-hydroxyphenylpyruvate dioxygenase K00457 GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0003868,GO:0006082,GO:0006520,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019752,GO:0019835,GO:0019836,GO:0031640,GO:0035821,GO:0043436,GO:0044003,GO:0044004,GO:0044179,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046395,GO:0051213,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.27 0.000000000000000000000000000001126 121.0
HKD2_k127_3881821_38 - - - - 0.000000000000000001599 87.0
HKD2_k127_3881821_4 Belongs to the citrate synthase family K01647 - 2.3.3.1 9.405e-264 815.0
HKD2_k127_3881821_5 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 6.512e-260 808.0
HKD2_k127_3881821_6 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 1.352e-241 765.0
HKD2_k127_3881821_7 nuclear chromosome segregation - - - 2.303e-234 752.0
HKD2_k127_3881821_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 3.738e-220 692.0
HKD2_k127_3881821_9 peptidylprolyl isomerase K01802,K03770 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001564 605.0
HKD2_k127_3883080_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0 1442.0
HKD2_k127_3883080_1 Acetylornithine deacetylase Succinyl-diaminopimelate - - - 7.271e-235 735.0
HKD2_k127_3883080_2 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 459.0
HKD2_k127_3883080_3 YHS domain protein - - - 0.00000000003415 66.0
HKD2_k127_3889208_0 amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002011 603.0
HKD2_k127_3889208_1 CHASE2 K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 584.0
HKD2_k127_3889208_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003739 378.0
HKD2_k127_3889208_3 CDP-alcohol phosphatidyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009507 322.0
HKD2_k127_3889208_4 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 303.0
HKD2_k127_3889208_5 Peptidase family M48 - - - 0.0000000000000000000000000000000000000000000000000000000000000004601 238.0
HKD2_k127_3889208_6 PAP2 superfamily - - - 0.000000000000000000000000000000000006684 149.0
HKD2_k127_3889208_7 Bacterial SH3 domain - - - 0.0000000000000000000000377 106.0
HKD2_k127_3889208_8 Pfam:DUF4102 - - - 0.00000000000000000003746 94.0
HKD2_k127_3895778_0 Subtilase family - - - 7.662e-208 681.0
HKD2_k127_3895778_1 alcohol dehydrogenase K00121 - 1.1.1.1,1.1.1.284 9.26e-207 647.0
HKD2_k127_3895778_10 cyclic nucleotide binding K07003,K10914 - - 0.00000000000000000000000000000000000000000000000000000000000000000001234 246.0
HKD2_k127_3895778_11 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000003646 207.0
HKD2_k127_3895778_12 PhnA protein K06193 - - 0.000000000000000000000000000000000000000000000000001032 191.0
HKD2_k127_3895778_13 Protein of unknown function (DUF1810) - - - 0.0000000000000000000000000000000000000000000001823 171.0
HKD2_k127_3895778_14 - K01865 - 5.4.4.1 0.00000000000000000000000000000000000000000000025 171.0
HKD2_k127_3895778_15 Ion channel - - - 0.000000000000000000000000000000000002053 144.0
HKD2_k127_3895778_17 - - - - 0.0000000000000001197 87.0
HKD2_k127_3895778_18 Belongs to the carbohydrate kinase PfkB family K16370 - 2.7.1.11 0.00000001341 63.0
HKD2_k127_3895778_2 Aminoglycoside phosphotransferase - - - 2.77e-200 632.0
HKD2_k127_3895778_3 Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols K04099 - 1.13.11.57 6.159e-199 628.0
HKD2_k127_3895778_4 succinate-hydroxymethylglutarate CoA-transferase activity - - - 1.162e-197 623.0
HKD2_k127_3895778_5 Zn-dependent dipeptidase, microsomal dipeptidase K01273 - 3.4.13.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 602.0
HKD2_k127_3895778_6 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004173 584.0
HKD2_k127_3895778_7 glutamine amidotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 522.0
HKD2_k127_3895778_8 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005558 495.0
HKD2_k127_3895778_9 Sugar (and other) transporter K08151 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 465.0
HKD2_k127_3906761_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0 1407.0
HKD2_k127_3906761_1 Belongs to the GPI family K01810 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 2.538e-244 764.0
HKD2_k127_3906761_10 iron ion binding - - - 0.00000000000000000000000000000000000000000000006214 179.0
HKD2_k127_3906761_11 cheY-homologous receiver domain K03413 - - 0.00000000000000000000000000000000000000000000106 175.0
HKD2_k127_3906761_12 - - - - 0.00000000000000000000000000000000001133 139.0
HKD2_k127_3906761_13 - - - - 0.0000000000000000000000000000002241 126.0
HKD2_k127_3906761_14 Outer membrane efflux protein K12543 - - 0.00000000000001676 76.0
HKD2_k127_3906761_2 5-aminolevulinic acid synthase K00643 - 2.3.1.37 1.449e-239 747.0
HKD2_k127_3906761_3 Rossmann fold nucleotide-binding protein involved in DNA uptake K04096 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006936 509.0
HKD2_k127_3906761_4 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 495.0
HKD2_k127_3906761_5 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001084 448.0
HKD2_k127_3906761_6 Provides the (R)-glutamate required for cell wall biosynthesis K01776 - 5.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002975 382.0
HKD2_k127_3906761_7 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006531 317.0
HKD2_k127_3906761_8 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001099 276.0
HKD2_k127_3906761_9 Cell Wall Hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000009309 228.0
HKD2_k127_3929117_0 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 4.059e-253 810.0
HKD2_k127_3929117_1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation K00626 - 2.3.1.9 3.782e-243 754.0
HKD2_k127_3929117_10 Tyrosine phosphatase family K01104 - 3.1.3.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002764 295.0
HKD2_k127_3929117_11 Chain-length determining protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003964 243.0
HKD2_k127_3929117_12 carboxylic ester hydrolase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000001595 234.0
HKD2_k127_3929117_13 Conjugal transfer protein TraJ K03203 - - 0.0000000000000000000000000000000000000000000000000003214 188.0
HKD2_k127_3929117_14 acyl carrier protein - - - 0.00000000000000000000000000000000002604 139.0
HKD2_k127_3929117_15 Type IV secretory pathway, VirB9 - - - 0.0000000000000000000000000000000001102 146.0
HKD2_k127_3929117_2 Belongs to the Orn Lys Arg decarboxylase class-II family K01586 - 4.1.1.20 2.087e-196 624.0
HKD2_k127_3929117_3 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002666 563.0
HKD2_k127_3929117_4 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005862 478.0
HKD2_k127_3929117_5 IV secretion system protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 417.0
HKD2_k127_3929117_6 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003195 382.0
HKD2_k127_3929117_7 polysaccharide export K01991 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007846 365.0
HKD2_k127_3929117_8 TIGRFAM Hydrolase, ortholog 1, exosortase system type 1 associated - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 323.0
HKD2_k127_3929117_9 Type IV secretory pathway, VirB10 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001699 291.0
HKD2_k127_3954045_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 1.012e-296 915.0
HKD2_k127_3954045_1 Amidohydrolase family - - - 7.465e-289 902.0
HKD2_k127_3954045_2 Putative esterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004488 603.0
HKD2_k127_3954045_3 tRNA synthetase, class II K02502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007548 552.0
HKD2_k127_3954045_4 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 437.0
HKD2_k127_3954045_5 Repeat of Unknown Function (DUF347) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 390.0
HKD2_k127_3954045_6 Cation transport regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 302.0
HKD2_k127_3954045_7 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008189 281.0
HKD2_k127_3954045_8 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000006817 249.0
HKD2_k127_3954045_9 - - - - 0.000000000000000000000000000000001468 138.0
HKD2_k127_4050975_0 argininosuccinate lyase K01755 - 4.3.2.1 1.755e-245 765.0
HKD2_k127_4050975_1 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 3.563e-215 673.0
HKD2_k127_4050975_2 Siroheme synthase K02302 - 1.3.1.76,2.1.1.107,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000001714 278.0
HKD2_k127_4050975_3 protein, possibly involved in aromatic compounds catabolism - - - 0.000000000000000000000000000000000000000005437 156.0
HKD2_k127_4050975_4 protein, possibly involved in aromatic compounds catabolism - - - 0.00000000000000000000000000000000000005738 151.0
HKD2_k127_4057380_0 Methylmalonate-semialdehyde dehydrogenase K00140 - 1.2.1.18,1.2.1.27 5.784e-296 912.0
HKD2_k127_4057380_1 acyl-CoA dehydrogenase K00249 - 1.3.8.7 1.9e-228 710.0
HKD2_k127_4057380_2 enoyl-CoA hydratase K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 426.0
HKD2_k127_4057380_3 Citrate synthase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 396.0
HKD2_k127_4118124_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1070.0
HKD2_k127_4118124_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666 - - 0.0 1015.0
HKD2_k127_4118124_10 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001251 281.0
HKD2_k127_4118124_11 NADH ubiquinone oxidoreductase 17.2 kD subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006729 244.0
HKD2_k127_4118124_12 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000000000000000000000000000000000000000000007343 214.0
HKD2_k127_4118124_13 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000000000000000000000000000000000003889 206.0
HKD2_k127_4118124_14 Regulatory protein RecX K03565 - - 0.0000000000000000000000000000000000000000000000000004812 191.0
HKD2_k127_4118124_15 Protein of unknown function (DUF2721) - - - 0.0000000000000000000000000000000000000000000004321 170.0
HKD2_k127_4118124_16 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) - - - 0.0000000000000000000000000000418 121.0
HKD2_k127_4118124_17 outer membrane autotransporter barrel domain K12685 - - 0.000000000000000000000000001308 130.0
HKD2_k127_4118124_2 COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 9.266e-246 789.0
HKD2_k127_4118124_3 Beta-Casp domain K07576 - - 8.055e-237 748.0
HKD2_k127_4118124_4 Toxic anion resistance - - - 8.37e-210 658.0
HKD2_k127_4118124_5 Dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 521.0
HKD2_k127_4118124_6 HlyD family secretion protein K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001879 424.0
HKD2_k127_4118124_7 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 352.0
HKD2_k127_4118124_8 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 317.0
HKD2_k127_4118124_9 Haloacid dehalogenase-like hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 310.0
HKD2_k127_4130161_0 ABC transporter - - - 0.0 1056.0
HKD2_k127_4130161_1 Belongs to the class-I aminoacyl-tRNA synthetase family K04566 - 6.1.1.6 4.191e-298 920.0
HKD2_k127_4130161_10 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006471 373.0
HKD2_k127_4130161_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000532 211.0
HKD2_k127_4130161_12 Nickel/cobalt transporter regulator - - - 0.0000000000000000000000000000000000000000000000000005472 197.0
HKD2_k127_4130161_13 Prokaryotic cytochrome b561 K12262 - - 0.0000000000000000000000000000000000000000001976 169.0
HKD2_k127_4130161_14 oxygenase K00472 - 1.14.11.2 0.00000000000000000000001256 109.0
HKD2_k127_4130161_15 Alpha/beta hydrolase family K06889 - - 0.000001026 50.0
HKD2_k127_4130161_2 TonB dependent receptor - - - 2.219e-257 806.0
HKD2_k127_4130161_3 protein conserved in bacteria - - - 3.162e-245 774.0
HKD2_k127_4130161_4 Peptidase, M28 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 602.0
HKD2_k127_4130161_5 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000995 580.0
HKD2_k127_4130161_6 RND efflux system, outer membrane lipoprotein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004322 511.0
HKD2_k127_4130161_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000305 499.0
HKD2_k127_4130161_8 lipopolysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 471.0
HKD2_k127_4130161_9 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 459.0
HKD2_k127_4135133_0 Ring hydroxylating alpha subunit (catalytic domain) - - - 6.335e-200 630.0
HKD2_k127_4135133_1 Rieske 2Fe-2S - - - 1.187e-195 620.0
HKD2_k127_4135133_2 Transketolase, pyrimidine binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 559.0
HKD2_k127_4135133_3 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000177 242.0
HKD2_k127_4135133_4 NmrA-like family - - - 0.0000000000000000000000000000000000000000000911 174.0
HKD2_k127_4135133_5 Short-chain dehydrogenase reductase sdr K00038 - 1.1.1.53 0.00000000000000000000000000000001876 134.0
HKD2_k127_4135133_6 SnoaL-like domain - - - 0.0000000000000000000000000001944 121.0
HKD2_k127_4135133_7 Biotin-requiring enzyme - - - 0.0000000000000000000000000004783 114.0
HKD2_k127_4166826_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 4.172e-231 728.0
HKD2_k127_4166826_1 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009706 379.0
HKD2_k127_4166826_2 nicotinamide mononucleotide transporter K03811 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 287.0
HKD2_k127_4166826_3 2-nitropropane dioxygenase K02371 - 1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000008106 250.0
HKD2_k127_4166826_4 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000002801 216.0
HKD2_k127_4169622_0 PQQ-like domain K17760 - 1.1.9.1 0.0 1088.0
HKD2_k127_4169622_1 TonB dependent receptor K02014 - - 1.11e-314 987.0
HKD2_k127_4169622_10 DNA-binding transcription factor activity - - - 0.000000000000000000000000000000000000000000000000000003372 194.0
HKD2_k127_4169622_11 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000002169 185.0
HKD2_k127_4169622_2 belongs to the aldehyde dehydrogenase family - - - 8.381e-260 810.0
HKD2_k127_4169622_3 Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process K05797 - 1.17.99.1 8.262e-204 641.0
HKD2_k127_4169622_4 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004252 432.0
HKD2_k127_4169622_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007764 431.0
HKD2_k127_4169622_6 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 408.0
HKD2_k127_4169622_7 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 324.0
HKD2_k127_4169622_8 Protein of unknown function (DUF3237) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000266 289.0
HKD2_k127_4169622_9 Amidohydrolase K07045,K14333,K20941 - 4.1.1.103,4.1.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004149 286.0
HKD2_k127_4197511_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1549.0
HKD2_k127_4197511_1 Belongs to the AAA ATPase family K13525 - - 0.0 1262.0
HKD2_k127_4197511_10 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008684 373.0
HKD2_k127_4197511_11 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004857 342.0
HKD2_k127_4197511_12 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 349.0
HKD2_k127_4197511_13 Haloacid dehalogenase-like hydrolase K07025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003769 325.0
HKD2_k127_4197511_14 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 310.0
HKD2_k127_4197511_15 Belongs to the universal stress protein A family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007979 277.0
HKD2_k127_4197511_16 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001941 261.0
HKD2_k127_4197511_17 Protein of unknown function (DUF1345) - - - 0.0000000000000000000000000000000000000000000000000000003815 206.0
HKD2_k127_4197511_18 Domain of unknown function (DUF4167) - - - 0.00000000000000000000000000000000000000000000000000007712 195.0
HKD2_k127_4197511_19 ABC-type (Unclassified) transport system, ATPase component K06861 - - 0.00000000000000000000000000000000000000000000008919 172.0
HKD2_k127_4197511_2 protease with the C-terminal PDZ - - - 4.733e-307 955.0
HKD2_k127_4197511_20 - - - - 0.00000000000000000000000000000000000000001049 157.0
HKD2_k127_4197511_21 - - - - 0.00002873 56.0
HKD2_k127_4197511_3 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 2.577e-236 734.0
HKD2_k127_4197511_4 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 6.409e-208 658.0
HKD2_k127_4197511_5 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 4.898e-196 616.0
HKD2_k127_4197511_6 modulator of DNA gyrase K03592 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 604.0
HKD2_k127_4197511_7 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 599.0
HKD2_k127_4197511_8 Luciferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 541.0
HKD2_k127_4197511_9 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 489.0
HKD2_k127_4212424_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 4.239e-317 978.0
HKD2_k127_4212424_1 peptidase U62, modulator of DNA gyrase K03568 - - 2.31e-230 715.0
HKD2_k127_4212424_2 cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 605.0
HKD2_k127_4212424_3 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000294 273.0
HKD2_k127_4212424_4 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000005232 209.0
HKD2_k127_4212424_5 - - - - 0.00000000000000000000000000000000000006462 153.0
HKD2_k127_4212424_6 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000003953 143.0
HKD2_k127_4330805_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 2.581e-245 761.0
HKD2_k127_4330805_1 chromate transporter K07240 - - 8.701e-211 663.0
HKD2_k127_4330805_10 protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis - - - 0.000000000000000000000000000000005208 128.0
HKD2_k127_4330805_12 Hypoxia induced protein conserved region - - - 0.00000000000006017 78.0
HKD2_k127_4330805_2 Chloride channel - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005507 604.0
HKD2_k127_4330805_3 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004346 501.0
HKD2_k127_4330805_4 Dehydrogenase K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 474.0
HKD2_k127_4330805_5 Belongs to the class-I aminoacyl-tRNA synthetase family K01894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 444.0
HKD2_k127_4330805_6 adenosyltransferase K00798 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002398 306.0
HKD2_k127_4330805_7 Protein of unknown function (DUF4019) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002278 254.0
HKD2_k127_4330805_8 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000007417 231.0
HKD2_k127_4330805_9 HNH endonuclease - - - 0.00000000000000000000000000000000482 128.0
HKD2_k127_4423818_0 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 4.618e-266 830.0
HKD2_k127_4423818_1 dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 593.0
HKD2_k127_4423818_2 Periplasmic copper-binding protein (NosD) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 510.0
HKD2_k127_4423818_3 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 440.0
HKD2_k127_4423818_4 aspartate racemase K01779 - 5.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 310.0
HKD2_k127_4423818_5 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004531 256.0
HKD2_k127_4423818_6 NAD(P) transhydrogenase subunit alpha K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000004816 243.0
HKD2_k127_4423818_7 nad(P) transhydrogenase subunit alpha K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000004778 174.0
HKD2_k127_4423818_8 - - - - 0.0000000000000000000000000000003932 126.0
HKD2_k127_4557913_0 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 1.789e-298 922.0
HKD2_k127_4557913_1 membrane K12340 - - 5.294e-206 657.0
HKD2_k127_4557913_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008986 432.0
HKD2_k127_4557913_3 LytTr DNA-binding domain K08083 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004057 355.0
HKD2_k127_4557913_4 Protein-L-isoaspartate O-methyltransferase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000002034 259.0
HKD2_k127_4557913_5 Protein of unknown function (DUF2497) K09991 - - 0.00000008585 54.0
HKD2_k127_4612716_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.856e-303 945.0
HKD2_k127_4612716_1 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 6.49e-256 797.0
HKD2_k127_4612716_10 light absorption - - - 0.0000000000000000000000000000007457 129.0
HKD2_k127_4612716_11 Belongs to the 'phage' integrase family - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000001397 64.0
HKD2_k127_4612716_12 NmrA-like family K19267 - 1.6.5.2 0.000000001637 60.0
HKD2_k127_4612716_2 Major Facilitator Superfamily - - - 2.061e-197 642.0
HKD2_k127_4612716_3 Amidohydrolase K14333 - 4.1.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003742 541.0
HKD2_k127_4612716_4 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006492 536.0
HKD2_k127_4612716_5 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002915 501.0
HKD2_k127_4612716_6 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009453 449.0
HKD2_k127_4612716_7 Dehydrogenase K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007347 441.0
HKD2_k127_4612716_8 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 401.0
HKD2_k127_4612716_9 exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008271 402.0
HKD2_k127_4653196_0 COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases K01426 - 3.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 520.0
HKD2_k127_4653196_1 pyridine nucleotide-disulfide oxidoreductase K00529 - 1.18.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003215 494.0
HKD2_k127_4653196_2 UPF0126 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 323.0
HKD2_k127_4653196_3 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000000000000000000000000000000000000803 226.0
HKD2_k127_4653196_4 - - - - 0.000000000000000000003302 93.0
HKD2_k127_4723728_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0 1207.0
HKD2_k127_4723728_1 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.0 1049.0
HKD2_k127_4723728_10 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008152 424.0
HKD2_k127_4723728_11 phosphoserine phosphatase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009867 370.0
HKD2_k127_4723728_12 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 K18586 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002129 323.0
HKD2_k127_4723728_13 acetolactate synthase K01653 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005056 296.0
HKD2_k127_4723728_14 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 297.0
HKD2_k127_4723728_15 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003763 271.0
HKD2_k127_4723728_16 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000000002562 196.0
HKD2_k127_4723728_17 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain - - - 0.0000000000000000000000000000000000000000000000000746 184.0
HKD2_k127_4723728_18 Predicted membrane protein (DUF2177) - - - 0.00000000000000000000000000000000000000000000001419 177.0
HKD2_k127_4723728_19 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000000000000000000000002297 129.0
HKD2_k127_4723728_2 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 1.393e-300 928.0
HKD2_k127_4723728_3 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 7.209e-205 641.0
HKD2_k127_4723728_4 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 5.306e-194 619.0
HKD2_k127_4723728_5 Alcohol dehydrogenase GroES-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 580.0
HKD2_k127_4723728_6 COG1960 Acyl-CoA dehydrogenases K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000188 563.0
HKD2_k127_4723728_7 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005244 584.0
HKD2_k127_4723728_8 acyl-CoA transferases carnitine dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 558.0
HKD2_k127_4723728_9 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003304 443.0
HKD2_k127_4797109_0 COG0156 7-keto-8-aminopelargonate synthetase and related enzymes K00639,K00652 - 2.3.1.29,2.3.1.47 7.356e-251 775.0
HKD2_k127_4797109_1 DedA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007524 330.0
HKD2_k127_4797109_10 - - - - 0.00000000000000000000000000000000001749 144.0
HKD2_k127_4797109_11 acyl carrier protein - - - 0.000000000000000000000000000000000816 135.0
HKD2_k127_4797109_12 Tautomerase enzyme - - - 0.00000000000000000000000000006383 118.0
HKD2_k127_4797109_13 Protein of unknown function (DUF3572) - - - 0.000000000000000000000000001919 115.0
HKD2_k127_4797109_14 Terminase RNaseH-like domain - - - 0.00001358 57.0
HKD2_k127_4797109_15 Terminase RNaseH-like domain - - - 0.00002726 49.0
HKD2_k127_4797109_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 330.0
HKD2_k127_4797109_3 UMP catabolic process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 314.0
HKD2_k127_4797109_4 Belongs to the ompA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 302.0
HKD2_k127_4797109_5 GDSL-like Lipase/Acylhydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002196 286.0
HKD2_k127_4797109_6 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001434 259.0
HKD2_k127_4797109_7 response regulator K11443 - - 0.000000000000000000000000000000000000000000000000000000000000006094 218.0
HKD2_k127_4797109_8 Terminase RNaseH-like domain - - - 0.000000000000000000000000000000000000000000000000000006033 192.0
HKD2_k127_4797109_9 Protein of unknown function (DUF2793) - - - 0.00000000000000000000000000000000000003554 146.0
HKD2_k127_49661_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000499 581.0
HKD2_k127_49661_1 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 440.0
HKD2_k127_49661_2 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 316.0
HKD2_k127_49661_3 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000000000000000000000000009427 243.0
HKD2_k127_49661_4 Belongs to the UPF0145 family - - - 0.0000000000000000000000000000000000000000002183 162.0
HKD2_k127_499880_0 Acyl-CoA dehydrogenase, middle domain - - - 1.881e-239 741.0
HKD2_k127_499880_1 Acyl-CoA dehydrogenase, N-terminal domain - - - 1.195e-194 612.0
HKD2_k127_499880_2 COG2211 Na melibiose symporter and related transporters - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 534.0
HKD2_k127_499880_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046 - 1.1.1.69 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005438 420.0
HKD2_k127_499880_4 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004674 397.0
HKD2_k127_499880_5 SMP-30/Gluconolaconase/LRE-like region - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001886 355.0
HKD2_k127_499880_6 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009682 346.0
HKD2_k127_499880_7 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000006146 243.0
HKD2_k127_499880_8 protein conserved in bacteria K09985 - - 0.0000000000000000000000000000000000001305 142.0
HKD2_k127_499880_9 - - - - 0.0000000002482 68.0
HKD2_k127_5127535_0 Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA K01638 - 2.3.3.9 0.0 1142.0
HKD2_k127_5127535_1 Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.0 1025.0
HKD2_k127_5127535_2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) K01484 - 3.5.3.23 1.681e-211 666.0
HKD2_k127_5127535_3 peptidylprolyl isomerase K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 594.0
HKD2_k127_5127535_4 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K01295 - 3.4.17.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 568.0
HKD2_k127_5127535_5 arginine N-succinyltransferase K00673 - 2.3.1.109 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006042 530.0
HKD2_k127_5127535_6 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000868 459.0
HKD2_k127_5127535_7 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006204 431.0
HKD2_k127_5129137_0 Polysaccharide deacetylase K22278 - 3.5.1.104 0.0 1641.0
HKD2_k127_5129137_1 Thi4 family - - - 8.173e-274 848.0
HKD2_k127_5129137_10 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 446.0
HKD2_k127_5129137_11 ribonuclease E activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 396.0
HKD2_k127_5129137_12 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003827 375.0
HKD2_k127_5129137_13 Uncharacterized protein conserved in bacteria (DUF2334) K06986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 309.0
HKD2_k127_5129137_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001172 288.0
HKD2_k127_5129137_15 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004381 251.0
HKD2_k127_5129137_16 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001468 250.0
HKD2_k127_5129137_17 Uncharacterized protein conserved in bacteria (DUF2141) - - - 0.00000000000000000000000000000000000000000000000000000000000000000002699 251.0
HKD2_k127_5129137_18 Putative MetA-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000198 235.0
HKD2_k127_5129137_19 phosphoglycolate phosphatase activity - - - 0.0000000000000000000000000000000000000000000000000000006367 194.0
HKD2_k127_5129137_2 acyl-CoA dehydrogenase K00249 - 1.3.8.7 1.141e-226 705.0
HKD2_k127_5129137_20 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.0000000000000000000000000000000000000000000004537 166.0
HKD2_k127_5129137_21 GtrA-like protein - - - 0.0000000000000000000000000000001082 128.0
HKD2_k127_5129137_22 Glycosyl transferase - - - 0.0000000000000000000000005791 111.0
HKD2_k127_5129137_23 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372 - 0.0000000000000000003644 89.0
HKD2_k127_5129137_26 Resolvase - - - 0.000002188 56.0
HKD2_k127_5129137_27 glycosyl transferase group 1 - - - 0.00005188 48.0
HKD2_k127_5129137_28 PDZ domain (Also known as DHR or GLGF) - - - 0.0001408 50.0
HKD2_k127_5129137_3 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 2.609e-212 676.0
HKD2_k127_5129137_4 enoyl-CoA hydratase K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 529.0
HKD2_k127_5129137_5 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 500.0
HKD2_k127_5129137_6 Glycosyltransferase Family 4 K14335 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 496.0
HKD2_k127_5129137_7 Belongs to the 3-hydroxyisobutyrate dehydrogenase family K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000414 449.0
HKD2_k127_5129137_8 Methylmalonate-semialdehyde dehydrogenase K00140 - 1.2.1.18,1.2.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000434 442.0
HKD2_k127_5129137_9 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001305 439.0
HKD2_k127_5151556_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1498.0
HKD2_k127_5151556_1 Belongs to the ClpA ClpB family K03694 - - 0.0 1425.0
HKD2_k127_5151556_10 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 505.0
HKD2_k127_5151556_11 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 484.0
HKD2_k127_5151556_12 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005091 485.0
HKD2_k127_5151556_13 molecular chaperone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003583 462.0
HKD2_k127_5151556_14 Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009578 452.0
HKD2_k127_5151556_15 COG0739 Membrane proteins related to metalloendopeptidases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001255 460.0
HKD2_k127_5151556_16 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005857 445.0
HKD2_k127_5151556_17 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family K13283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002526 430.0
HKD2_k127_5151556_18 ribonuclease BN K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006662 420.0
HKD2_k127_5151556_19 protein conserved in bacteria K09987 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004778 401.0
HKD2_k127_5151556_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K01897 - 6.2.1.3 1.221e-236 744.0
HKD2_k127_5151556_20 Belongs to the GST superfamily K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004653 366.0
HKD2_k127_5151556_21 Membrane-bound metallopeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008844 368.0
HKD2_k127_5151556_22 isomerase K01809 - 5.3.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004467 360.0
HKD2_k127_5151556_23 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006447 325.0
HKD2_k127_5151556_24 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002284 286.0
HKD2_k127_5151556_25 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001381 271.0
HKD2_k127_5151556_26 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004664 264.0
HKD2_k127_5151556_27 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000000000000000000000000000000000002216 237.0
HKD2_k127_5151556_28 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000007951 215.0
HKD2_k127_5151556_29 Disulfide bond formation protein - - - 0.0000000000000000000000000000000000000000000000000000000001831 206.0
HKD2_k127_5151556_3 Belongs to the peptidase S41A family K03797 - 3.4.21.102 9.327e-210 661.0
HKD2_k127_5151556_30 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.000000000000000000000000000000000000000000000000000000005377 202.0
HKD2_k127_5151556_31 Protein of unknown function (DUF1153) - - - 0.00000000000000000000000000000000000000000000000000000345 192.0
HKD2_k127_5151556_32 - - - - 0.000000000000000000000000000000000000000000000001073 184.0
HKD2_k127_5151556_33 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000000000000001461 161.0
HKD2_k127_5151556_34 Transglycosylase associated protein - - - 0.000000000000000000000000000000000000008487 146.0
HKD2_k127_5151556_35 - - - - 0.00000000000000000000000000000001132 137.0
HKD2_k127_5151556_36 Gram-negative bacterial TonB protein C-terminal - - - 0.0000000000000000000000000005727 127.0
HKD2_k127_5151556_37 Protein of unknown function (DUF1192) - - - 0.000000000000000001599 87.0
HKD2_k127_5151556_38 Bacterial-like globin K06886 - - 0.0000000000000006654 79.0
HKD2_k127_5151556_4 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 1.494e-204 643.0
HKD2_k127_5151556_5 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 7.564e-204 639.0
HKD2_k127_5151556_6 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 582.0
HKD2_k127_5151556_7 NADPH quinone - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 528.0
HKD2_k127_5151556_8 Electron transfer flavoprotein K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 522.0
HKD2_k127_5151556_9 Mannose-1-phosphate guanylyltransferase K00971 - 2.7.7.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005702 501.0
HKD2_k127_5181180_0 Alpha Beta K07018 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 438.0
HKD2_k127_5181180_1 Bacterial protein of unknown function (DUF937) - - - 0.000000000000000000000000000000001691 136.0
HKD2_k127_5181180_2 - - - - 0.0000000000002775 76.0
HKD2_k127_5181180_3 protein conserved in bacteria - - - 0.00000000001028 69.0
HKD2_k127_5217667_0 TonB-dependent Receptor Plug Domain - - - 0.0 1152.0
HKD2_k127_5217667_1 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 1.201e-271 842.0
HKD2_k127_5217667_2 Sulfotransferase family - - - 1.091e-252 787.0
HKD2_k127_5217667_3 Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate K00451 - 1.13.11.5 3.913e-206 648.0
HKD2_k127_5217667_4 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000167 449.0
HKD2_k127_5217667_5 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 399.0
HKD2_k127_5217667_6 Prolyl-tRNA synthetase - - - 0.000000000000000000000000000000000000000000000000000000000007804 210.0
HKD2_k127_5251863_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951,K01139 - 2.7.6.5,3.1.7.2 8.903e-249 781.0
HKD2_k127_5251863_1 coproporphyrinogen III oxidase K00228 - 1.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 507.0
HKD2_k127_5251863_2 Transporter K03761 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 355.0
HKD2_k127_5251863_3 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 318.0
HKD2_k127_5251863_4 ICC-like phosphoesterases K06953 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007567 323.0
HKD2_k127_5251863_5 Lipoprotein K04754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003185 287.0
HKD2_k127_5272434_0 Autotransporter beta-domain - - - 0.0 1330.0
HKD2_k127_5272434_1 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 0.0 1040.0
HKD2_k127_5272434_10 Fe2 -dicitrate sensor, membrane component K07165 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004441 332.0
HKD2_k127_5272434_11 Endonuclease/Exonuclease/phosphatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002677 273.0
HKD2_k127_5272434_12 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000008322 222.0
HKD2_k127_5272434_13 Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system K02017 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 0.00000000000000000000000000000000000000000000000000000000000001025 222.0
HKD2_k127_5272434_14 Bacterial regulatory helix-turn-helix protein, lysR family K02019 - - 0.00000000000000000000000000000000000000000000000000007582 189.0
HKD2_k127_5272434_15 Phosphoribosyl transferase domain K07100 - - 0.0000000000000000000000000000387 119.0
HKD2_k127_5272434_17 COG0457 FOG TPR repeat - - - 0.00000000000000000007381 94.0
HKD2_k127_5272434_2 Outer membrane receptor - - - 1.73e-314 983.0
HKD2_k127_5272434_3 Tryptophan halogenase K14266 - 1.14.19.9 1.614e-258 809.0
HKD2_k127_5272434_4 Glycosyl hydrolase family 3 C-terminal domain - - - 1.721e-243 768.0
HKD2_k127_5272434_5 Belongs to the glycosyl hydrolase 30 family K01201 - 3.2.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006299 491.0
HKD2_k127_5272434_6 lacI family K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001762 377.0
HKD2_k127_5272434_7 Molybdate K02018 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009334 364.0
HKD2_k127_5272434_8 Major Facilitator Superfamily K02429 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 371.0
HKD2_k127_5272434_9 Molybdenum ABC transporter K02020 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001353 351.0
HKD2_k127_5273864_0 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 3.769e-271 844.0
HKD2_k127_5273864_1 Threonine dehydratase K01754 - 4.3.1.19 3.974e-208 654.0
HKD2_k127_5273864_2 highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001717 529.0
HKD2_k127_5273864_3 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 464.0
HKD2_k127_5273864_4 COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005473 460.0
HKD2_k127_5273864_5 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 410.0
HKD2_k127_5273864_6 Metal-dependent hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000004549 240.0
HKD2_k127_5273864_7 Phage lysozyme - - - 0.00000000000000000000000000004567 118.0
HKD2_k127_5273864_8 lysozyme K01185 - 3.2.1.17 0.0000000000000000000001336 100.0
HKD2_k127_5278799_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1157.0
HKD2_k127_5278799_1 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 0.0 1114.0
HKD2_k127_5278799_10 Low temperature requirement A - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 450.0
HKD2_k127_5278799_11 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002973 436.0
HKD2_k127_5278799_12 7TM diverse intracellular signalling - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005124 440.0
HKD2_k127_5278799_13 Acyl-CoA thioesterase K10805 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005624 406.0
HKD2_k127_5278799_14 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 392.0
HKD2_k127_5278799_15 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001683 371.0
HKD2_k127_5278799_16 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007066 367.0
HKD2_k127_5278799_17 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008991 347.0
HKD2_k127_5278799_18 Antirepressor regulating drug resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004249 351.0
HKD2_k127_5278799_19 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 330.0
HKD2_k127_5278799_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0 1094.0
HKD2_k127_5278799_20 COG0491 Zn-dependent hydrolases, including glyoxylases K17837 - 3.5.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 321.0
HKD2_k127_5278799_21 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000278 328.0
HKD2_k127_5278799_22 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 288.0
HKD2_k127_5278799_23 molecular chaperone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002184 280.0
HKD2_k127_5278799_24 3-demethylubiquinone-9 3-methyltransferase K00568 - 2.1.1.222,2.1.1.64 0.0000000000000000000000000000000000000000000000000000000000000000000000000002735 260.0
HKD2_k127_5278799_25 Glutathione-dependent formaldehyde-activating enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003973 248.0
HKD2_k127_5278799_26 enzyme related to lactoylglutathione lyase K06996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002368 249.0
HKD2_k127_5278799_27 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000006302 228.0
HKD2_k127_5278799_28 Lactoylglutathione lyase K07032 - - 0.00000000000000000000000000000000000000000000000000000000000003136 216.0
HKD2_k127_5278799_29 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000000000000000000000000000007708 230.0
HKD2_k127_5278799_3 Prolyl oligopeptidase family - - - 2.466e-303 945.0
HKD2_k127_5278799_30 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000001769 218.0
HKD2_k127_5278799_31 Activator of Hsp90 ATPase - - - 0.000000000000000000000000000000000000000000000000000000000001978 218.0
HKD2_k127_5278799_32 transcriptional regulator K16137 - - 0.000000000000000000000000000000000000000000000000000000000002203 218.0
HKD2_k127_5278799_33 succinate dehydrogenase K00242 - - 0.0000000000000000000000000000000000000000000000000000000005333 204.0
HKD2_k127_5278799_34 succinate dehydrogenase K00241 - - 0.0000000000000000000000000000000000000000000000000000004236 197.0
HKD2_k127_5278799_35 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000006569 186.0
HKD2_k127_5278799_36 Belongs to the BolA IbaG family K05527 - - 0.000000000000000000000000000000000000005518 147.0
HKD2_k127_5278799_4 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 3.597e-218 692.0
HKD2_k127_5278799_5 Outer membrane receptor proteins, mostly Fe transport - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000534 607.0
HKD2_k127_5278799_6 Aerobic cobaltochelatase subunit CobS K09882 - 6.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005936 574.0
HKD2_k127_5278799_7 Uncharacterized protein conserved in bacteria (DUF2332) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009889 548.0
HKD2_k127_5278799_8 ribosomal protein L11 K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 472.0
HKD2_k127_5278799_9 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002148 445.0
HKD2_k127_5328112_0 TonB dependent receptor K02014 - - 0.0 1117.0
HKD2_k127_5328112_1 Prolyl oligopeptidase family - - - 2.76e-198 639.0
HKD2_k127_5328112_10 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000227 177.0
HKD2_k127_5328112_11 asparagine synthase K01953 - 6.3.5.4 0.0000000000000000000000004994 121.0
HKD2_k127_5328112_12 Prophage CP4-57 regulatory protein (AlpA) K07733 - - 0.0000000000000000002654 89.0
HKD2_k127_5328112_2 Domain of unknown function (DUF4172) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 446.0
HKD2_k127_5328112_3 Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 430.0
HKD2_k127_5328112_4 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002761 294.0
HKD2_k127_5328112_5 Uncharacterized conserved protein (DUF2285) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002868 288.0
HKD2_k127_5328112_6 Acyl-homoserine-lactone synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002088 257.0
HKD2_k127_5328112_7 Transglutaminase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000006167 224.0
HKD2_k127_5328112_8 FecR protein K07165 - - 0.000000000000000000000000000000000000000000000000000000000001919 221.0
HKD2_k127_5328112_9 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000001598 196.0
HKD2_k127_5341572_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 9.318e-306 945.0
HKD2_k127_5341572_1 amino acid K03294 - - 5.152e-297 915.0
HKD2_k127_5341572_10 Inositol monophosphatase K01092 - 3.1.3.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006177 488.0
HKD2_k127_5341572_11 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 363.0
HKD2_k127_5341572_12 Bile acid sodium symporter K14347 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003199 319.0
HKD2_k127_5341572_13 SOS response K14160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005232 273.0
HKD2_k127_5341572_14 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000438 267.0
HKD2_k127_5341572_15 Protein of unknown function (DUF3501) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002918 256.0
HKD2_k127_5341572_2 Nucleotidyltransferase DNA polymerase involved in DNA repair K14161 - - 4.544e-244 774.0
HKD2_k127_5341572_3 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02481 - - 2.235e-242 755.0
HKD2_k127_5341572_4 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 2.42e-237 753.0
HKD2_k127_5341572_5 sugar transferase - - - 3.878e-220 690.0
HKD2_k127_5341572_6 Cysteine-rich domain K00113 - 1.1.5.3 1.212e-216 680.0
HKD2_k127_5341572_7 L-carnitine dehydratase bile acid-inducible protein F K01796 - 5.1.99.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005281 595.0
HKD2_k127_5341572_8 protein conserved in bacteria K09799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002087 552.0
HKD2_k127_5341572_9 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 497.0
HKD2_k127_5345368_0 Involved in the TonB-independent uptake of proteins K03641 - - 4.456e-238 746.0
HKD2_k127_5345368_1 molecular chaperone - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007352 315.0
HKD2_k127_5345368_2 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003188 273.0
HKD2_k127_5345368_3 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004434 250.0
HKD2_k127_5345368_4 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000004043 229.0
HKD2_k127_5345368_5 Biopolymer transport protein K03560 - - 0.000000000000000000000000000000000000000000000000000000003585 203.0
HKD2_k127_5345368_6 MotA TolQ ExbB proton channel K03562 - - 0.000000000000000000000649 95.0
HKD2_k127_5379351_0 peptidase S9 K01354 - 3.4.21.83 0.0 1210.0
HKD2_k127_5379351_1 aminopeptidase K01262 - 3.4.11.9 7.896e-313 968.0
HKD2_k127_5379351_10 Histidine kinase - - - 0.0000000000000001954 87.0
HKD2_k127_5379351_2 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 2.906e-209 654.0
HKD2_k127_5379351_3 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006746 395.0
HKD2_k127_5379351_4 7TM diverse intracellular signalling - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009981 352.0
HKD2_k127_5379351_5 thioesterase K07107 - - 0.0000000000000000000000000000000000000000000000000000000000000000005315 233.0
HKD2_k127_5379351_6 COG0346 Lactoylglutathione lyase and related lyases - - - 0.00000000000000000000000000000000000000000000000000000000005522 206.0
HKD2_k127_5379351_7 YHS domain protein - - - 0.000000000000000000000000000000000000000000000000000001353 194.0
HKD2_k127_5379351_8 EF-hand, calcium binding motif - - - 0.000000000000000000000000000000000000001558 157.0
HKD2_k127_5379351_9 cell redox homeostasis - - - 0.00000000000000000000000009952 114.0
HKD2_k127_5384670_0 Required for chromosome condensation and partitioning K03529 - - 0.0 1499.0
HKD2_k127_5384670_1 Peptidase, M16 K07263 - - 0.0 1221.0
HKD2_k127_5384670_10 Pyrrolo-quinoline quinone - - - 2.406e-198 628.0
HKD2_k127_5384670_11 COG0463 Glycosyltransferases involved in cell wall biogenesis K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001414 608.0
HKD2_k127_5384670_12 Branched-chain amino acid aminotransferase K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008451 602.0
HKD2_k127_5384670_13 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004634 585.0
HKD2_k127_5384670_14 protein-S-isoprenylcysteine methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 587.0
HKD2_k127_5384670_15 Phosphate starvation-inducible protein PhoH K06217 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000231 576.0
HKD2_k127_5384670_16 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 572.0
HKD2_k127_5384670_17 C-terminal four TMM region of protein-O-mannosyltransferase K00728 - 2.4.1.109 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 534.0
HKD2_k127_5384670_18 Belongs to the methyltransferase superfamily K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000137 524.0
HKD2_k127_5384670_19 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000449 521.0
HKD2_k127_5384670_2 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 2.092e-276 860.0
HKD2_k127_5384670_20 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 488.0
HKD2_k127_5384670_21 Glycosyl transferase family 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 489.0
HKD2_k127_5384670_22 Heme copper-type cytochrome quinol oxidase, subunit 3 K02276 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 482.0
HKD2_k127_5384670_23 glycosylase K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002235 481.0
HKD2_k127_5384670_24 Predicted metal-dependent hydrolase K07044 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006758 483.0
HKD2_k127_5384670_25 Transcriptional regulator K03566 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 464.0
HKD2_k127_5384670_26 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006267 462.0
HKD2_k127_5384670_27 Belongs to the Nudix hydrolase family K03426 - 3.6.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009977 463.0
HKD2_k127_5384670_28 TonB dependent receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002787 462.0
HKD2_k127_5384670_29 Glutathione S-transferase K11209 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 441.0
HKD2_k127_5384670_3 phospho-2-dehydro-3-deoxyheptonate aldolase K01626 - 2.5.1.54 6.329e-268 828.0
HKD2_k127_5384670_30 Hemolysin K06442 - 2.1.1.226,2.1.1.227 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 437.0
HKD2_k127_5384670_31 COG1253 Hemolysins and related proteins containing CBS domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003042 436.0
HKD2_k127_5384670_32 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009356 433.0
HKD2_k127_5384670_33 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003887 430.0
HKD2_k127_5384670_34 Protein of unknown function (DUF3089) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000901 426.0
HKD2_k127_5384670_35 permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002474 426.0
HKD2_k127_5384670_36 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006431 412.0
HKD2_k127_5384670_37 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001878 398.0
HKD2_k127_5384670_38 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006919 408.0
HKD2_k127_5384670_39 Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 401.0
HKD2_k127_5384670_4 Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate K06447 - 1.2.1.71 5.866e-263 817.0
HKD2_k127_5384670_40 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008521 380.0
HKD2_k127_5384670_41 COG1680 Beta-lactamase class C and other penicillin binding proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005201 389.0
HKD2_k127_5384670_42 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006842 377.0
HKD2_k127_5384670_43 RarD protein K05786 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 347.0
HKD2_k127_5384670_44 Aminomethyltransferase K06980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001507 338.0
HKD2_k127_5384670_45 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 337.0
HKD2_k127_5384670_46 Nitroreductase family K09019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004356 328.0
HKD2_k127_5384670_47 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006248 327.0
HKD2_k127_5384670_48 COG0694 Thioredoxin-like proteins and domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 325.0
HKD2_k127_5384670_49 Belongs to the arylamine N-acetyltransferase family K00675 - 2.3.1.118 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 324.0
HKD2_k127_5384670_5 glutamate--cysteine ligase K01919 - 6.3.2.2 7.258e-258 799.0
HKD2_k127_5384670_50 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 323.0
HKD2_k127_5384670_51 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 314.0
HKD2_k127_5384670_52 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005738 313.0
HKD2_k127_5384670_53 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K03767 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 297.0
HKD2_k127_5384670_54 dithiol-disulfide isomerase involved in polyketide biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 295.0
HKD2_k127_5384670_55 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 287.0
HKD2_k127_5384670_56 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001456 281.0
HKD2_k127_5384670_57 Protein of unknown function (DUF721) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006267 278.0
HKD2_k127_5384670_58 Tetratricopeptide repeat-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006602 280.0
HKD2_k127_5384670_59 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000528 281.0
HKD2_k127_5384670_6 Threonine synthase K01733 - 4.2.3.1 3.824e-256 795.0
HKD2_k127_5384670_60 Belongs to the Fur family K03711 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001669 264.0
HKD2_k127_5384670_61 peptidase M22 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005137 259.0
HKD2_k127_5384670_62 Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I K02258 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002474 254.0
HKD2_k127_5384670_63 Predicted membrane protein (DUF2238) K08984 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001556 267.0
HKD2_k127_5384670_64 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001393 254.0
HKD2_k127_5384670_65 Protein-disulfide isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002435 251.0
HKD2_k127_5384670_66 transcriptional K13639 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008407 239.0
HKD2_k127_5384670_67 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000048 236.0
HKD2_k127_5384670_68 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000000000000000000000000000000000000000000001596 237.0
HKD2_k127_5384670_69 Molybdopterin converting factor, large subunit K03635 - 2.8.1.12 0.0000000000000000000000000000000000000000000000000000000000000000003573 233.0
HKD2_k127_5384670_7 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 6.827e-238 748.0
HKD2_k127_5384670_70 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 - - 0.000000000000000000000000000000000000000000000000000000000000000001429 232.0
HKD2_k127_5384670_71 Protein-disulfide isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000231 226.0
HKD2_k127_5384670_72 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000004556 218.0
HKD2_k127_5384670_73 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000000000000000000000000003759 216.0
HKD2_k127_5384670_74 SURF1-like protein K14998 - - 0.000000000000000000000000000000000000000000000000000000000004446 218.0
HKD2_k127_5384670_75 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000005509 209.0
HKD2_k127_5384670_76 dihydroneopterin aldolase K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.0000000000000000000000000000000000000000000000000000006782 194.0
HKD2_k127_5384670_77 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000000000000000000000000000000000001629 191.0
HKD2_k127_5384670_78 FKBP-type peptidyl-prolyl cis-trans isomerase K03772 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000003458 193.0
HKD2_k127_5384670_79 Acetyltransferase K03789 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000006428 199.0
HKD2_k127_5384670_8 Uncharacterized ACR, YdiU/UPF0061 family - - - 3.332e-229 718.0
HKD2_k127_5384670_80 Protein of unknown function (DUF1489) - - - 0.000000000000000000000000000000000000000000000000000572 186.0
HKD2_k127_5384670_81 Protein of unknown function (DUF983) - - - 0.00000000000000000000000000000000000000000000000009262 182.0
HKD2_k127_5384670_82 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000000000000000000001809 168.0
HKD2_k127_5384670_83 - - - - 0.0000000000000000000000000000000000000000001872 164.0
HKD2_k127_5384670_84 transcriptional regulator - - - 0.00000000000000000000000000000000000000001716 160.0
HKD2_k127_5384670_85 Glycine zipper 2TM domain - - - 0.000000000000000000000000000000000000001418 151.0
HKD2_k127_5384670_86 - - - - 0.00000000000000000000000000000000621 135.0
HKD2_k127_5384670_87 Antibiotic biosynthesis monooxygenase - - - 0.000000000000000000000000000001561 123.0
HKD2_k127_5384670_89 Membrane fusogenic activity K09806 - - 0.0000000000000000000000000005284 119.0
HKD2_k127_5384670_9 Acts as a magnesium transporter K06213 - - 3.263e-211 666.0
HKD2_k127_5391315_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 1.216e-261 816.0
HKD2_k127_5391315_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00833 - 2.6.1.62 2.93e-205 651.0
HKD2_k127_5391315_2 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism K01012 - 2.8.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006612 580.0
HKD2_k127_5391315_3 8-amino-7-oxononanoate synthase K00652 - 2.3.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 455.0
HKD2_k127_5391315_4 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000000000000000000000002943 201.0
HKD2_k127_5391315_5 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000001284 186.0
HKD2_k127_5391315_6 protein conserved in bacteria K09948 - - 0.00000000000000000000000000000000000000000000002192 173.0
HKD2_k127_5391315_7 Belongs to the UPF0335 family - - - 0.0000000000000000000000000000000002671 142.0
HKD2_k127_5391315_8 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring K01935,K02169 GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197,6.3.3.3 0.0000000000000000000001268 113.0
HKD2_k127_5432751_0 COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit K00174 - 1.2.7.11,1.2.7.3 0.0 1110.0
HKD2_k127_5432751_1 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001659 522.0
HKD2_k127_5432751_2 PFAM Alpha beta hydrolase fold-3 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000372 463.0
HKD2_k127_5432751_3 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002901 417.0
HKD2_k127_5432751_4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004452 270.0
HKD2_k127_5432751_5 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004348 269.0
HKD2_k127_5432751_6 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000001189 212.0
HKD2_k127_5501661_0 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 517.0
HKD2_k127_5501661_1 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 321.0
HKD2_k127_5501661_2 recombinase activity - - - 0.00006319 49.0
HKD2_k127_5523036_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.0 1107.0
HKD2_k127_5523036_1 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA K01610 - 4.1.1.49 7.194e-312 960.0
HKD2_k127_5523036_10 glycosyl transferase group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002364 541.0
HKD2_k127_5523036_11 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 481.0
HKD2_k127_5523036_12 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 479.0
HKD2_k127_5523036_13 Displays ATPase and GTPase activities K06958 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 447.0
HKD2_k127_5523036_14 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007208 437.0
HKD2_k127_5523036_15 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005668 432.0
HKD2_k127_5523036_16 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002841 428.0
HKD2_k127_5523036_17 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003548 427.0
HKD2_k127_5523036_18 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K14981 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 383.0
HKD2_k127_5523036_19 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 346.0
HKD2_k127_5523036_2 Belongs to the TPP enzyme family K01652 - 2.2.1.6 1.975e-308 952.0
HKD2_k127_5523036_20 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002953 354.0
HKD2_k127_5523036_21 7TM diverse intracellular signalling - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 310.0
HKD2_k127_5523036_22 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006172 259.0
HKD2_k127_5523036_23 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003586 260.0
HKD2_k127_5523036_24 FR47-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003728 266.0
HKD2_k127_5523036_25 PTS fructose transporter subunit IIA K02793 - 2.7.1.191 0.000000000000000000000000000000000000000000000000000000000000000124 226.0
HKD2_k127_5523036_26 - - - - 0.00000000000000000000000000000000000000000000000000005236 191.0
HKD2_k127_5523036_27 surface antigen - - - 0.0000000000000000000000000000000000000000000000002601 186.0
HKD2_k127_5523036_28 Serine kinase of the HPr protein, regulates carbohydrate metabolism - - - 0.00000000000000000000000000000000000000000003759 164.0
HKD2_k127_5523036_29 COG1925 Phosphotransferase system, HPr-related proteins K11189 - - 0.000000000000000000000000000001614 127.0
HKD2_k127_5523036_3 belongs to the aldehyde dehydrogenase family - - - 4.67e-263 815.0
HKD2_k127_5523036_30 transcriptional regulator - - - 0.00000000000000000004248 98.0
HKD2_k127_5523036_4 Belongs to the formate--tetrahydrofolate ligase family K01938 - 6.3.4.3 1.072e-261 815.0
HKD2_k127_5523036_5 May be involved in recombinational repair of damaged DNA K03631 - - 5.671e-258 805.0
HKD2_k127_5523036_6 protein conserved in bacteria - - - 8.009e-225 704.0
HKD2_k127_5523036_7 Histidine kinase K14980 - 2.7.13.3 1.755e-209 665.0
HKD2_k127_5523036_8 DNA recombination protein K09760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002276 580.0
HKD2_k127_5523036_9 alcohol dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 553.0
HKD2_k127_5535105_0 Ferrous iron transport protein B K04759 - - 2.412e-311 963.0
HKD2_k127_5535105_1 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase K06147 - - 5.883e-301 932.0
HKD2_k127_5535105_10 Metal-dependent hydrolase K07043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 318.0
HKD2_k127_5535105_11 RpsU-divergently transcribed K18587 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007451 310.0
HKD2_k127_5535105_12 conserved protein UCP033924 precursor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001576 310.0
HKD2_k127_5535105_13 gag-polyprotein putative aspartyl protease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006039 284.0
HKD2_k127_5535105_14 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002993 264.0
HKD2_k127_5535105_15 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001489 269.0
HKD2_k127_5535105_16 Ankyrin repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001135 256.0
HKD2_k127_5535105_17 protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000292 248.0
HKD2_k127_5535105_18 Protocatechuate 4,5-dioxygenase K04100 - 1.13.11.8 0.0000000000000000000000000000000000000000000000000000000000000000000002548 239.0
HKD2_k127_5535105_19 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007211 243.0
HKD2_k127_5535105_2 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 4.785e-238 740.0
HKD2_k127_5535105_20 Belongs to the UPF0260 family K09160 - - 0.00000000000000000000000000000000000000000000000000000000000000000001113 240.0
HKD2_k127_5535105_21 Nitroreductase family - - - 0.00000000000000000000000000000000000000000000000000000001971 203.0
HKD2_k127_5535105_22 Ubiquinol-cytochrome C chaperone K17662 - - 0.0000000000000000000000000000000000000000000000000000007237 197.0
HKD2_k127_5535105_23 Riboflavin synthase alpha chain K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000007549 200.0
HKD2_k127_5535105_24 Small protein A (tmRNA-binding) - - - 0.00000000000000000000000000000000000000000000000000001452 194.0
HKD2_k127_5535105_25 Uncharacterized ACR, COG1399 - - - 0.000000000000000000000000000000000000000000000000008141 187.0
HKD2_k127_5535105_26 Uncharacterized conserved protein (DUF2267) - - - 0.00000000000000000000000000000000000000000000000002122 183.0
HKD2_k127_5535105_27 PFAM PEBP family protein K06910 - - 0.00000000000000000000000000000000000000000001577 170.0
HKD2_k127_5535105_28 Protein of unknown function (DUF983) - - - 0.0000000000000000000000000000000000000005541 154.0
HKD2_k127_5535105_29 Domain of unknown function (DUF1737) - - - 0.0000000000000000000000000000000001151 132.0
HKD2_k127_5535105_3 PFAM Aminotransferase class I and II K00832 - 2.6.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006494 604.0
HKD2_k127_5535105_30 Fe2 transport system protein A K04758 - - 0.000000000000000000000000000001973 123.0
HKD2_k127_5535105_31 - - - - 0.000000000000000000000000003919 116.0
HKD2_k127_5535105_32 - - - - 0.000000000000000067 85.0
HKD2_k127_5535105_4 Polysaccharide biosynthesis protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 602.0
HKD2_k127_5535105_5 DNA polymerase X family K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004841 578.0
HKD2_k127_5535105_6 Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols K04101 - 1.13.11.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005642 526.0
HKD2_k127_5535105_7 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007375 465.0
HKD2_k127_5535105_8 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005566 325.0
HKD2_k127_5535105_9 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008934 327.0
HKD2_k127_5565260_0 COG0156 7-keto-8-aminopelargonate synthetase and related enzymes K00639,K00652 - 2.3.1.29,2.3.1.47 4.438e-250 773.0
HKD2_k127_5565260_1 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 447.0
HKD2_k127_5565260_10 Protein of unknown function (DUF3572) - - - 0.0000000000000000000000000003233 116.0
HKD2_k127_5565260_2 DedA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003717 336.0
HKD2_k127_5565260_3 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003315 332.0
HKD2_k127_5565260_4 UMP catabolic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005915 314.0
HKD2_k127_5565260_5 GDSL-like Lipase/Acylhydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008897 295.0
HKD2_k127_5565260_6 Glutathione S-transferase, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008064 263.0
HKD2_k127_5565260_7 response regulator K11443 - - 0.0000000000000000000000000000000000000000000000000000000000000334 218.0
HKD2_k127_5565260_8 acyl carrier protein - - - 0.0000000000000000000000000000000004522 135.0
HKD2_k127_5565260_9 Tautomerase enzyme - - - 0.00000000000000000000000000006383 118.0
HKD2_k127_5594334_0 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007168 469.0
HKD2_k127_5594334_1 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001526 370.0
HKD2_k127_5594334_2 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 351.0
HKD2_k127_5594334_3 Cupin 2, conserved barrel - - - 0.00000000000000000000000000000000000000000000000000000003532 196.0
HKD2_k127_5594334_4 Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process K05797 - 1.17.99.1 0.0000000000000000000000000000000000000000000000000000002427 203.0
HKD2_k127_5594334_5 COG2010 Cytochrome c, mono- and diheme variants - - - 0.00000000000000000000000216 114.0
HKD2_k127_5607991_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.0 1239.0
HKD2_k127_5607991_1 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 2.188e-227 719.0
HKD2_k127_5607991_2 SnoaL-like polyketide cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000038 233.0
HKD2_k127_5607991_3 Transcriptional regulator - - - 0.000000000000000000000000000000000000000109 165.0
HKD2_k127_5607991_4 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000003753 80.0
HKD2_k127_5624504_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 2.75e-310 956.0
HKD2_k127_5624504_1 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006725 445.0
HKD2_k127_5624504_2 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007389 384.0
HKD2_k127_5624504_3 Plays a role in the regulation of phosphate uptake K02039 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 342.0
HKD2_k127_5650869_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0 1419.0
HKD2_k127_5650869_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 2.993e-275 856.0
HKD2_k127_5650869_2 Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA K00253 - 1.3.8.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 547.0
HKD2_k127_5650869_3 Putative S-adenosyl-L-methionine-dependent methyltransferase K18164 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 505.0
HKD2_k127_5650869_4 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K13584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 463.0
HKD2_k127_5650869_5 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003428 464.0
HKD2_k127_5650869_6 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 451.0
HKD2_k127_5698324_0 Penicillin-binding Protein K05515 - 3.4.16.4 0.0 1016.0
HKD2_k127_5698324_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 2.036e-312 966.0
HKD2_k127_5698324_2 rod shape-determining protein MreB K03569 - - 8.635e-211 658.0
HKD2_k127_5698324_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 582.0
HKD2_k127_5698324_4 copper resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008978 559.0
HKD2_k127_5698324_5 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002969 418.0
HKD2_k127_5698324_6 Involved in formation and maintenance of cell shape K03570 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005935 340.0
HKD2_k127_5698324_7 rod shape-determining protein MreD K03571 - - 0.0000000000000000000000000000000000000000000000000000000000000001106 228.0
HKD2_k127_5698324_8 dehydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000001146 227.0
HKD2_k127_5698450_0 Helicase K03722 - 3.6.4.12 0.0 1447.0
HKD2_k127_5698450_1 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.039e-215 678.0
HKD2_k127_5698450_2 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009923 596.0
HKD2_k127_5698450_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000571 515.0
HKD2_k127_5698450_4 phosphohistidine phosphatase K08296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002422 286.0
HKD2_k127_5698450_5 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000000003724 162.0
HKD2_k127_5698450_6 transcriptional - - - 0.00000000000000000000000000000000000002012 148.0
HKD2_k127_5698450_7 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.00000000000000000000000000000007014 124.0
HKD2_k127_5698450_8 TonB dependent receptor K02014 - - 0.00000000000001654 72.0
HKD2_k127_5795166_0 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008431 586.0
HKD2_k127_5795166_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000004829 237.0
HKD2_k127_5795166_2 - - - - 0.000000000000000000000000000000000000000000000000001163 204.0
HKD2_k127_5795166_3 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000003307 55.0
HKD2_k127_58017_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 2.182e-262 824.0
HKD2_k127_58017_1 Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine K01761 - 4.4.1.11 1.264e-228 717.0
HKD2_k127_58017_2 Transporter K03761 - - 0.000000000000000000000000000000000000000000000000000001863 196.0
HKD2_k127_5885926_0 chemotaxis protein K03407 - 2.7.13.3 3.637e-201 652.0
HKD2_k127_5885926_1 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003069 581.0
HKD2_k127_5885926_2 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 383.0
HKD2_k127_5885926_3 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K03406 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002717 381.0
HKD2_k127_5885926_4 COG1352 Methylase of chemotaxis methyl-accepting proteins K00575 - 2.1.1.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 319.0
HKD2_k127_5885926_5 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000002807 237.0
HKD2_k127_5885926_6 chemotaxis K03413 - - 0.00000000000000000000000000000000000000000000000000000000000000008161 222.0
HKD2_k127_5885926_7 Predicted membrane protein (DUF2306) - - - 0.00000000000000000000000000000000000000000002752 169.0
HKD2_k127_5885926_8 Two component signalling adaptor domain K03408 - - 0.000000000000000000000000000000004646 133.0
HKD2_k127_5908495_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0 1372.0
HKD2_k127_5908495_1 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 0.0 1257.0
HKD2_k127_5908495_10 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005364 430.0
HKD2_k127_5908495_11 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 396.0
HKD2_k127_5908495_12 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008128 330.0
HKD2_k127_5908495_13 2-hydroxychromene-2-carboxylate isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002101 305.0
HKD2_k127_5908495_14 L,D-transpeptidase catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000193 265.0
HKD2_k127_5908495_15 Helix-turn-helix domain - - - 0.000000000000000000000000000000000000000000000000000000000000008375 227.0
HKD2_k127_5908495_16 Aldolase K01625 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 4.1.2.14,4.1.3.42 0.0000000000000000000000000000000000000000000000000000000000007775 225.0
HKD2_k127_5908495_17 tetR family - - - 0.00000000000000000000000000000000000000000000000000001202 196.0
HKD2_k127_5908495_18 Protein of unknown function (DUF1465) K13592 - - 0.00000000000000000000000000000000000000000002138 168.0
HKD2_k127_5908495_19 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.000000000000000000000000000036 118.0
HKD2_k127_5908495_2 Oxidoreductase - - - 4.924e-314 968.0
HKD2_k127_5908495_20 Protein of unknown function (DUF465) - - - 0.000000000000000000000000488 106.0
HKD2_k127_5908495_21 Small protein - - - 0.0000000000001418 77.0
HKD2_k127_5908495_22 Sulfotransferase family - - - 0.0000000000007748 77.0
HKD2_k127_5908495_3 Belongs to the IlvD Edd family K01690 - 4.2.1.12 5.014e-314 972.0
HKD2_k127_5908495_4 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 7.023e-249 775.0
HKD2_k127_5908495_5 Ring hydroxylating alpha subunit (catalytic domain) - - - 3.527e-209 655.0
HKD2_k127_5908495_6 Acetylornithine deacetylase Succinyl-diaminopimelate - - - 2.126e-206 651.0
HKD2_k127_5908495_7 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001072 517.0
HKD2_k127_5908495_8 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 496.0
HKD2_k127_5908495_9 alcohol dehydrogenase K13979 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 451.0
HKD2_k127_5939807_0 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002332 572.0
HKD2_k127_5939807_1 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008687 424.0
HKD2_k127_5939807_2 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K13642 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000863 293.0
HKD2_k127_5939807_3 - K07112 - - 0.0000000000000000000000000000000000000007789 153.0
HKD2_k127_5939807_4 transporter component K07112 - - 0.0000000000000000000000000000000000005367 150.0
HKD2_k127_5939807_5 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000007927 125.0
HKD2_k127_5970844_0 NADH-quinone oxidoreductase K00336 - 1.6.5.3 1.612e-269 835.0
HKD2_k127_5970844_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000187 87.0
HKD2_k127_6094090_0 AAA domain K07133 - - 6.087e-200 627.0
HKD2_k127_6094090_1 Nucleotidyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 432.0
HKD2_k127_6094090_2 Conserved protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001996 387.0
HKD2_k127_6094090_3 - - - - 0.00000000000000000000000000000000000000000000000000000000009567 206.0
HKD2_k127_6094090_4 Protein of unknown function (DUF736) - - - 0.00000000000000000000000000000000000000000000000000003222 190.0
HKD2_k127_6094090_5 domain protein K02238 - - 0.0000000000000000000000005915 119.0
HKD2_k127_6103759_0 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 5.059e-253 788.0
HKD2_k127_6103759_1 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001212 584.0
HKD2_k127_6103759_2 NAD(P) transhydrogenase subunit alpha K00324 - 1.6.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 454.0
HKD2_k127_6103759_3 Bacterial aa3 type cytochrome c oxidase subunit IV - - - 0.0002152 45.0
HKD2_k127_6171816_0 Sulfite reductase K00381 - 1.8.1.2 0.0 1007.0
HKD2_k127_6171816_1 cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 457.0
HKD2_k127_6171816_10 Protein of unknown function (DUF2849) - - - 0.00000000000000000000000000000000005217 134.0
HKD2_k127_6171816_11 - - - - 0.0000000000000000000001468 102.0
HKD2_k127_6171816_12 Thioredoxin-like - - - 0.000000000000000000003551 100.0
HKD2_k127_6171816_2 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 406.0
HKD2_k127_6171816_3 epimerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 372.0
HKD2_k127_6171816_4 Protein involved in meta-pathway of phenol degradation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002225 343.0
HKD2_k127_6171816_5 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005883 263.0
HKD2_k127_6171816_6 Class III cytochrome C family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001137 259.0
HKD2_k127_6171816_7 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000009162 202.0
HKD2_k127_6171816_8 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000002457 177.0
HKD2_k127_6171816_9 Reduction of activated sulfate into sulfite K00390 - 1.8.4.10,1.8.4.8 0.0000000000000000000000000000000000000007883 152.0
HKD2_k127_630504_0 Prolyl oligopeptidase K01322 - 3.4.21.26 0.0 1086.0
HKD2_k127_630504_1 MaoC like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004682 280.0
HKD2_k127_630504_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000004673 239.0
HKD2_k127_630504_3 Ribosomal protein L17 K02879 - - 0.0000000000000000000000000000000000000000000000000000000000000000004532 230.0
HKD2_k127_630504_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000001215 197.0
HKD2_k127_630504_6 Fatty acid hydroxylase superfamily - - - 0.00000000000000000000000000000001544 137.0
HKD2_k127_630504_7 pyridine nucleotide-disulfide oxidoreductase K00529 - 1.18.1.3 0.00000000000000000000000000001053 126.0
HKD2_k127_6387877_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K02472 - 1.1.1.336 2.788e-233 730.0
HKD2_k127_6387877_1 Saccharopine dehydrogenase NADP binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 602.0
HKD2_k127_6387877_10 Predicted integral membrane protein (DUF2282) - - - 0.000000000000000000000000000000003878 131.0
HKD2_k127_6387877_11 Putative DNA-binding domain - - - 0.00000000000000000000000000006685 119.0
HKD2_k127_6387877_12 Domain of unknown function (DUF1330) - - - 0.0000000000000000000000000000904 119.0
HKD2_k127_6387877_13 DoxX K15977 - - 0.0000000000000000000000000003484 117.0
HKD2_k127_6387877_14 - - - - 0.000000000000000000000006818 106.0
HKD2_k127_6387877_15 - - - - 0.000000000000000001152 96.0
HKD2_k127_6387877_2 Belongs to the UDP-N-acetylglucosamine 2-epimerase family K01791 - 5.1.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008537 578.0
HKD2_k127_6387877_3 epimerase dehydratase K08679 - 5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 542.0
HKD2_k127_6387877_4 Belongs to the UPF0276 family K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 443.0
HKD2_k127_6387877_5 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 382.0
HKD2_k127_6387877_6 Limonene-1,2-epoxide hydrolase catalytic domain K10533 - 3.3.2.8 0.0000000000000000000000000000000000000000000000000000004499 194.0
HKD2_k127_6387877_7 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000001227 182.0
HKD2_k127_6387877_8 Glutathione-dependent formaldehyde-activating enzyme - - - 0.00000000000000000000000000000000000000000000000002327 183.0
HKD2_k127_6387877_9 COG0477 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000002178 166.0
HKD2_k127_6429354_0 Acyl-CoA dehydrogenase, middle domain - - - 3.982e-237 735.0
HKD2_k127_6429354_1 Acyl-CoA dehydrogenase, N-terminal domain - - - 5.125e-196 616.0
HKD2_k127_6429354_2 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005804 441.0
HKD2_k127_6429354_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00046 - 1.1.1.69 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 419.0
HKD2_k127_6429354_4 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004257 351.0
HKD2_k127_6429354_5 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 351.0
HKD2_k127_6429354_6 SMP-30/Gluconolaconase/LRE-like region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008849 351.0
HKD2_k127_6429354_7 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001566 342.0
HKD2_k127_6429354_8 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009488 274.0
HKD2_k127_6429354_9 protein conserved in bacteria K09985 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001387 267.0
HKD2_k127_6435200_0 PFAM Hydantoinase oxoprolinase K01473 - 3.5.2.14 0.0 1207.0
HKD2_k127_6435200_1 PFAM Hydantoinase B oxoprolinase K01474 - 3.5.2.14 0.0 1191.0
HKD2_k127_6435200_2 dehydratase K07749 - 2.8.3.16 3.912e-228 709.0
HKD2_k127_6435200_3 TonB-dependent receptor K02014 - - 2.817e-219 687.0
HKD2_k127_6435200_4 HMGL-like K01640 - 4.1.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 454.0
HKD2_k127_6435200_5 Isochorismatase family K13995 - 3.5.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003977 325.0
HKD2_k127_6435200_6 FCD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001107 264.0
HKD2_k127_6435200_7 Autotransporter beta-domain - - - 0.000000000000000000000000000000000000000000000000004564 207.0
HKD2_k127_6442603_0 Peptidase S8 and S53 subtilisin kexin sedolisin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 422.0
HKD2_k127_6442603_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000627 313.0
HKD2_k127_6442603_3 Sigma-70, region 4 - - - 0.000000000000000000000000000000000000000000000000000000000000006042 220.0
HKD2_k127_6442603_4 Bacterial protein of unknown function (Gcw_chp) - - - 0.0000000000000000000000000000000000000000000000000000000008576 210.0
HKD2_k127_6442603_5 Putative zinc-finger - - - 0.0000000000000000000000000000000000000000000000000000002 203.0
HKD2_k127_6442603_6 COG3316 Transposase and inactivated derivatives K07498 - - 0.000001657 51.0
HKD2_k127_6472136_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1624.0
HKD2_k127_6472136_1 Putative cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007375 321.0
HKD2_k127_6472136_2 - - - - 0.00000000000000000000000000000000000000000000000000000006692 211.0
HKD2_k127_6472136_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000001105 118.0
HKD2_k127_6472136_4 - - - - 0.0000000000000000000000000001448 116.0
HKD2_k127_6473519_0 Autotransporter beta-domain - - - 0.0 1332.0
HKD2_k127_6473519_1 Bacterial capsule synthesis protein PGA_cap - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004342 391.0
HKD2_k127_6473519_2 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003424 345.0
HKD2_k127_6473519_3 Aminoglycoside phosphotransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003485 295.0
HKD2_k127_6473519_4 Phosphoribosyl transferase domain K07100 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001114 254.0
HKD2_k127_6473519_5 Outer membrane receptor - - - 0.00000000000000000000823 92.0
HKD2_k127_6484927_0 penicillin-binding protein K05366 - 2.4.1.129,3.4.16.4 0.0 1007.0
HKD2_k127_6484927_1 aerobic-type carbon monoxide dehydrogenase, large subunit CoxL K07303 - 1.3.99.16 7.184e-287 906.0
HKD2_k127_6484927_2 Belongs to the peptidase S1C family K04771 - 3.4.21.107 4.154e-242 756.0
HKD2_k127_6484927_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007486 477.0
HKD2_k127_6484927_4 HflC and HflK could encode or regulate a protease K04088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 419.0
HKD2_k127_6484927_5 HflC and HflK could regulate a protease K04087 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 369.0
HKD2_k127_6484927_6 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000004161 255.0
HKD2_k127_6484927_7 outer membrane autotransporter barrel domain K12685 - - 0.0000000000000000000000000000000000000000000000000000000000000000003938 262.0
HKD2_k127_6502337_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.0 1214.0
HKD2_k127_6502337_1 Protein of unknown function (DUF3376) - - - 1.251e-320 998.0
HKD2_k127_6502337_10 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001297 551.0
HKD2_k127_6502337_11 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005735 547.0
HKD2_k127_6502337_12 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006356 546.0
HKD2_k127_6502337_13 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005034 459.0
HKD2_k127_6502337_14 Belongs to the 'phage' integrase family K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 454.0
HKD2_k127_6502337_15 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002964 408.0
HKD2_k127_6502337_16 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003204 407.0
HKD2_k127_6502337_17 Isochorismatase family K09020 - 3.5.1.110 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002702 372.0
HKD2_k127_6502337_18 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 363.0
HKD2_k127_6502337_19 Heat shock 70 kDa protein K04043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 351.0
HKD2_k127_6502337_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 4.167e-284 878.0
HKD2_k127_6502337_20 membrane-associated protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006737 293.0
HKD2_k127_6502337_21 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003288 282.0
HKD2_k127_6502337_22 synthesis repressor PhaR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001044 256.0
HKD2_k127_6502337_23 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000012 246.0
HKD2_k127_6502337_24 - - - - 0.000000000000000000000000000000000000000000000000000000000000001935 222.0
HKD2_k127_6502337_25 Colicin V production protein K03558 - - 0.0000000000000000000000000000000000000000000000000000000000001269 217.0
HKD2_k127_6502337_26 Universal stress protein - - - 0.00000000000000000000000000000000000000000000000000000000005369 215.0
HKD2_k127_6502337_27 NifU homolog involved in Fe-S cluster formation - - - 0.000000000000000000000000000000000000000001518 159.0
HKD2_k127_6502337_28 Copper chaperone PCu(A)C K09796 - - 0.00000000000000000000000000000000000000003753 159.0
HKD2_k127_6502337_29 Protein of unknown function (DUF805) - - - 0.0000000000000000000000000000000000000008028 154.0
HKD2_k127_6502337_3 Major Facilitator - - - 1.919e-269 837.0
HKD2_k127_6502337_30 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000000000000000000545 147.0
HKD2_k127_6502337_31 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.0000000000000000000000000000003863 133.0
HKD2_k127_6502337_32 Pilus assembly protein PilZ - - - 0.0000001406 57.0
HKD2_k127_6502337_4 COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes K00382 - 1.8.1.4 5.985e-266 823.0
HKD2_k127_6502337_5 Heat shock 70 kDa protein K04043 - - 1.665e-255 792.0
HKD2_k127_6502337_6 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 8.207e-237 737.0
HKD2_k127_6502337_7 Indoleamine 2,3-dioxygenase K00463 - 1.13.11.52 8.434e-201 631.0
HKD2_k127_6502337_8 Involved in the biosynthesis of porphyrin-containing compound - - - 3.656e-195 616.0
HKD2_k127_6502337_9 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 567.0
HKD2_k127_6509781_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 589.0
HKD2_k127_6509781_1 Membrane dipeptidase (Peptidase family M19) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 576.0
HKD2_k127_6509781_10 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000006409 83.0
HKD2_k127_6509781_2 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007518 547.0
HKD2_k127_6509781_3 Threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002285 496.0
HKD2_k127_6509781_4 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007247 474.0
HKD2_k127_6509781_5 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001701 410.0
HKD2_k127_6509781_6 Glycerophosphoryl diester phosphodiesterase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004756 312.0
HKD2_k127_6509781_7 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000006631 257.0
HKD2_k127_6509781_8 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000048 227.0
HKD2_k127_6509781_9 GCN5-related N-acetyl-transferase K06975 - - 0.000000000000000000000000000000008874 136.0
HKD2_k127_6605790_0 Belongs to the transketolase family K00615 - 2.2.1.1 8.479e-318 984.0
HKD2_k127_6605790_1 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 3.119e-216 675.0
HKD2_k127_6605790_10 - - - - 0.00000000000000000000000000000000006673 139.0
HKD2_k127_6605790_11 Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division K09888 - - 0.000000000000000000000000000008209 124.0
HKD2_k127_6605790_12 Protein of unknown function (DUF2842) - - - 0.000000000000000000001403 96.0
HKD2_k127_6605790_2 COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit K00167 - 1.2.4.4 2.935e-214 672.0
HKD2_k127_6605790_3 Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex K09699 - 2.3.1.168 1.024e-198 627.0
HKD2_k127_6605790_4 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 1.364e-196 616.0
HKD2_k127_6605790_5 Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis K01623 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000612 430.0
HKD2_k127_6605790_6 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 396.0
HKD2_k127_6605790_7 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family K01934 - 6.3.3.2 0.0000000000000000000000000000000000000000000000000000000000000005424 228.0
HKD2_k127_6605790_8 COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit K00166 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000005076 199.0
HKD2_k127_6605790_9 TIGRFAM conserved repeat domain - - - 0.000000000000000000000000000000000000000008073 160.0
HKD2_k127_6624581_0 FAD binding domain K05712,K20218 - 1.14.13.127 1.466e-197 627.0
HKD2_k127_6624581_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008778 431.0
HKD2_k127_6624581_2 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002499 442.0
HKD2_k127_6624581_3 TIR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001423 408.0
HKD2_k127_6624581_4 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001861 283.0
HKD2_k127_6624581_5 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005862 252.0
HKD2_k127_6624581_6 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009281 248.0
HKD2_k127_6624581_7 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000001503 206.0
HKD2_k127_6624581_8 AntiSigma factor - - - 0.00000000000000000000000000000000000000000000000000111 193.0
HKD2_k127_6624581_9 Crp-like helix-turn-helix domain - - - 0.000000000000000000000000000000000000000002855 164.0
HKD2_k127_6640625_0 LVIVD repeat - - - 0.0 2275.0
HKD2_k127_6640625_1 4Fe-4S dicluster domain - - - 0.0 1325.0
HKD2_k127_6640625_10 Cytochrome c554 and c-prime - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 582.0
HKD2_k127_6640625_11 COG3210 Large exoproteins involved in heme utilization or adhesion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003793 625.0
HKD2_k127_6640625_12 Carboxylesterase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 397.0
HKD2_k127_6640625_13 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002665 398.0
HKD2_k127_6640625_14 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009767 328.0
HKD2_k127_6640625_15 cytochrome c biogenesis K02200 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 301.0
HKD2_k127_6640625_16 Secretion protein, HlyD K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002023 287.0
HKD2_k127_6640625_17 - - - - 0.00000000000000000000000000000000000000000000000000000000001345 214.0
HKD2_k127_6640625_18 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000008984 203.0
HKD2_k127_6640625_2 - - - - 0.0 1011.0
HKD2_k127_6640625_3 CHAT domain - - - 3.444e-314 997.0
HKD2_k127_6640625_4 Haem-degrading - - - 7.374e-296 921.0
HKD2_k127_6640625_5 Belongs to the Glu Leu Phe Val dehydrogenases family K00261,K00262 - 1.4.1.3,1.4.1.4 9.939e-278 857.0
HKD2_k127_6640625_6 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 1.332e-269 846.0
HKD2_k127_6640625_7 Cytochrome c3 - - - 1.421e-234 738.0
HKD2_k127_6640625_8 Major facilitator superfamily K03446 - - 1.68e-214 678.0
HKD2_k127_6640625_9 COG2831 Hemolysin activation secretion protein - - - 7.16e-213 676.0
HKD2_k127_6679419_0 cell division K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004487 433.0
HKD2_k127_6679419_1 Cell division protein K09811 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000706 317.0
HKD2_k127_6679419_2 DUF218 domain - - - 0.00000000000000000000000000000000000000000000000000000003311 209.0
HKD2_k127_6679419_3 Acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000002905 130.0
HKD2_k127_6679419_4 zinc-ribbon domain - - - 0.00000000000002281 73.0
HKD2_k127_6760369_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 - 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 420.0
HKD2_k127_6760369_1 CarD family transcriptional regulator K07736 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 319.0
HKD2_k127_6760369_2 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.000000000000000000000000000000000000000000000000000000000000000000004877 235.0
HKD2_k127_6760369_3 Putative auto-transporter adhesin, head GIN domain - - - 0.000000000000000000000000000000000000000000000000000000000000009629 231.0
HKD2_k127_6808937_0 Flavin-binding monooxygenase-like - - - 1.156e-286 885.0
HKD2_k127_6808937_1 Flavin-binding monooxygenase-like K18277 - 1.14.13.148 2.577e-258 800.0
HKD2_k127_6808937_10 PFAM Enoyl-CoA hydratase isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 316.0
HKD2_k127_6808937_11 Protein of unknown function (DUF2585) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001032 274.0
HKD2_k127_6808937_12 - - - - 0.000000000000000000000000000000000000000000000000000000000000000001118 235.0
HKD2_k127_6808937_13 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000000000000005743 214.0
HKD2_k127_6808937_14 MltA-interacting protein MipA - - - 0.00000000000000000000000000000000000000000000000000000000002291 226.0
HKD2_k127_6808937_2 Phytoene dehydrogenase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 4.505e-246 773.0
HKD2_k127_6808937_3 Cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 608.0
HKD2_k127_6808937_4 Prephenate dehydratase K04518 - 4.2.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002003 517.0
HKD2_k127_6808937_5 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002559 492.0
HKD2_k127_6808937_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004311 460.0
HKD2_k127_6808937_7 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 369.0
HKD2_k127_6808937_8 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003807 327.0
HKD2_k127_6808937_9 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002479 329.0
HKD2_k127_6832737_0 YjgP YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002653 591.0
HKD2_k127_6832737_1 YjgP YjgQ family K11720 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000271 500.0
HKD2_k127_6832737_2 membrane - - - 0.000000000000000000000000000000000000000000000000000000000002647 212.0
HKD2_k127_6832737_3 Fatty acid hydroxylase - - - 0.0000000000000005323 81.0
HKD2_k127_6862395_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 1.585e-313 967.0
HKD2_k127_6862395_1 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003449 512.0
HKD2_k127_6862395_2 beta-N-acetylhexosaminidase K01207 - 3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003189 501.0
HKD2_k127_6862395_3 Oxidoreductase K19746 - 1.4.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 497.0
HKD2_k127_6862395_4 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004428 494.0
HKD2_k127_6862395_5 Lysophospholipase K01048 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004035 467.0
HKD2_k127_6862395_6 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001187 296.0
HKD2_k127_6862395_7 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000000000697 250.0
HKD2_k127_6862395_8 Sporulation related domain - - - 0.0000000000000000000000000000000000000000000000000001527 205.0
HKD2_k127_6862395_9 Domain of unknown function (DUF1508) K09946 - - 0.00000000000000000000001041 107.0
HKD2_k127_6883857_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.0 1272.0
HKD2_k127_6883857_1 cytochrome C K02198 - - 0.0 1028.0
HKD2_k127_6883857_10 Belongs to the iron ascorbate-dependent oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 524.0
HKD2_k127_6883857_11 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002976 521.0
HKD2_k127_6883857_12 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002475 507.0
HKD2_k127_6883857_13 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 425.0
HKD2_k127_6883857_14 zinc metalloprotease K11749 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003534 422.0
HKD2_k127_6883857_15 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002337 387.0
HKD2_k127_6883857_16 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008265 387.0
HKD2_k127_6883857_17 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 385.0
HKD2_k127_6883857_18 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002643 366.0
HKD2_k127_6883857_19 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 356.0
HKD2_k127_6883857_2 Transport of potassium into the cell K03549 - - 2.502e-315 975.0
HKD2_k127_6883857_20 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 314.0
HKD2_k127_6883857_21 probably involved in intracellular septation K06190 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006882 274.0
HKD2_k127_6883857_22 Urate oxidase N-terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001853 266.0
HKD2_k127_6883857_23 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000000000000000000000000000000002038 252.0
HKD2_k127_6883857_24 Cytochrome c biogenesis factor K02200 - - 0.000000000000000000000000000000000000000000000000000000000000000000001318 245.0
HKD2_k127_6883857_25 Alkyl hydroperoxide reductase K02199 - - 0.000000000000000000000000000000000000000000000000000000000000000000002985 250.0
HKD2_k127_6883857_26 Outer membrane protein (OmpH-like) - - - 0.000000000000000000000000000000000000000000000000000000000000000008022 236.0
HKD2_k127_6883857_27 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000005477 228.0
HKD2_k127_6883857_28 EVE domain - - - 0.00000000000000000000000000000000000000000000000000000000000000335 221.0
HKD2_k127_6883857_29 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.000000000000000000000000000000000000000000000000000000000000004581 219.0
HKD2_k127_6883857_3 Belongs to the TPP enzyme family K01652 - 2.2.1.6 2.923e-275 854.0
HKD2_k127_6883857_30 subunit of a heme lyase K02200 - - 0.0000000000000000000000000000000000000000000000000004358 188.0
HKD2_k127_6883857_31 50S ribosomal protein L31 K02909 - - 0.000000000000000000000000000000000000002123 147.0
HKD2_k127_6883857_33 Helix-turn-helix domain - - - 0.000000000000000000000000000000739 126.0
HKD2_k127_6883857_35 - - - - 0.000000000001299 70.0
HKD2_k127_6883857_4 Major facilitator superfamily - - - 1.003e-205 647.0
HKD2_k127_6883857_5 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 597.0
HKD2_k127_6883857_6 aminotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 583.0
HKD2_k127_6883857_7 2-methylthioadenine K18707 - 2.8.4.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003179 557.0
HKD2_k127_6883857_8 signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000073 559.0
HKD2_k127_6883857_9 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006416 532.0
HKD2_k127_6904427_0 acetyltransferase - - - 8.056e-196 616.0
HKD2_k127_6904427_1 permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000027 418.0
HKD2_k127_6904427_2 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 414.0
HKD2_k127_6904427_3 Fatty acid hydroxylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002114 346.0
HKD2_k127_69249_0 belongs to the aldehyde dehydrogenase family K00146 - 1.2.1.39 1.163e-284 884.0
HKD2_k127_69249_1 Amidohydrolase K07045 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001326 572.0
HKD2_k127_69249_10 Taurine catabolism dioxygenase TauD, TfdA family K03119 - 1.14.11.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004161 338.0
HKD2_k127_69249_11 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003448 318.0
HKD2_k127_69249_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006838 265.0
HKD2_k127_69249_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000002024 235.0
HKD2_k127_69249_14 Putative phosphatase (DUF442) - - - 0.0000000000000000000000000000000000000000000000000000000001946 219.0
HKD2_k127_69249_15 TonB dependent receptor - - - 0.00000000000000006102 83.0
HKD2_k127_69249_2 MFS/sugar transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 516.0
HKD2_k127_69249_3 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 496.0
HKD2_k127_69249_4 AMP-binding enzyme C-terminal domain K00666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000077 500.0
HKD2_k127_69249_5 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002793 485.0
HKD2_k127_69249_6 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 458.0
HKD2_k127_69249_7 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 396.0
HKD2_k127_69249_8 IclR helix-turn-helix domain K05818 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 377.0
HKD2_k127_69249_9 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006339 345.0
HKD2_k127_6936285_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 7.782e-216 686.0
HKD2_k127_6936285_1 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003382 460.0
HKD2_k127_6936285_2 Belongs to the PEP-utilizing enzyme family K08484 - 2.7.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007397 346.0
HKD2_k127_6936285_3 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 340.0
HKD2_k127_6936285_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001929 249.0
HKD2_k127_6936285_5 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000004135 242.0
HKD2_k127_6936285_6 Protein of unknown function (DUF1465) K13592 - - 0.00000000000000000000000000000000000000000001008 168.0
HKD2_k127_6936285_7 Protein of unknown function (DUF465) - - - 0.0000000000000000000000002591 107.0
HKD2_k127_6936285_8 Protein of unknown function (DUF465) - - - 0.00000000000005562 78.0
HKD2_k127_6977947_0 amino acid K03294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001896 565.0
HKD2_k127_6977947_1 Phytoene dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000004051 218.0
HKD2_k127_6977947_2 Sulfotransferase family - - - 0.00000000001042 78.0
HKD2_k127_7322520_0 D-arabinono-1,4-lactone oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 574.0
HKD2_k127_7322520_1 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 490.0
HKD2_k127_7322520_2 Domain of unknown function (DUF1794) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001036 350.0
HKD2_k127_7322520_3 amino acid aldolase or racemase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 342.0
HKD2_k127_7322520_4 Hsp20/alpha crystallin family K13993 - - 0.0000000000000000000000000000000000000000000000000000000000000000006177 237.0
HKD2_k127_7322520_5 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000006572 215.0
HKD2_k127_7322520_6 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000001614 173.0
HKD2_k127_7322520_7 transcriptional regulator - - - 0.00000000000000000000000000000000000007277 152.0
HKD2_k127_7322520_8 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000001047 136.0
HKD2_k127_7322520_9 - - - - 0.000007653 50.0
HKD2_k127_7446550_0 glutamate dehydrogenase K15371 - 1.4.1.2 0.0 2104.0
HKD2_k127_7446550_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0 1118.0
HKD2_k127_7446550_10 ABC transporter, ATP-binding protein K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003458 552.0
HKD2_k127_7446550_11 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000107 519.0
HKD2_k127_7446550_12 amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002654 493.0
HKD2_k127_7446550_13 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 449.0
HKD2_k127_7446550_14 ABC-type Na efflux pump, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 437.0
HKD2_k127_7446550_15 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000572 395.0
HKD2_k127_7446550_16 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004965 363.0
HKD2_k127_7446550_17 MobA-like NTP transferase domain K07281 - 2.7.7.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001494 336.0
HKD2_k127_7446550_18 NnrU protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003001 305.0
HKD2_k127_7446550_19 conserved domain frequently associated with peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000003552 255.0
HKD2_k127_7446550_2 Heparinase - - - 6.533e-299 927.0
HKD2_k127_7446550_20 Belongs to the Fur family K09823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001191 248.0
HKD2_k127_7446550_21 CDP-alcohol phosphatidyltransferase K07281,K07291 - 2.7.7.74,2.7.8.34 0.00000000000000000000000000000000000000000000000000000000000000000001048 247.0
HKD2_k127_7446550_22 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000002008 224.0
HKD2_k127_7446550_23 Uncharacterized protein conserved in bacteria (DUF2141) - - - 0.0000000000000000000000000000000000000000000000000000000001355 209.0
HKD2_k127_7446550_24 Transcriptional regulator K07979 - - 0.00000000000000000000000000000000000000000000002557 171.0
HKD2_k127_7446550_25 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.0000000000000000000000000000000000000000004918 160.0
HKD2_k127_7446550_26 PilZ domain - - - 0.0000000000000000000000000000000000000003817 157.0
HKD2_k127_7446550_27 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000009226 143.0
HKD2_k127_7446550_3 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 2.151e-294 909.0
HKD2_k127_7446550_4 amino acid peptide transporter K03305 - - 9.658e-289 897.0
HKD2_k127_7446550_5 cytochrome P450 - - - 7.945e-243 756.0
HKD2_k127_7446550_6 amidohydrolase - - - 8.81e-221 698.0
HKD2_k127_7446550_7 Inositol-3-phosphate synthase K01858 - 5.5.1.4 1.36e-213 670.0
HKD2_k127_7446550_8 Alkaline phosphatase K01113 - 3.1.3.1 3.895e-205 655.0
HKD2_k127_7446550_9 Belongs to the amidase family K01426 - 3.5.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 587.0
HKD2_k127_75233_0 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007937 361.0
HKD2_k127_75233_1 Enoyl-(Acyl carrier protein) reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 359.0
HKD2_k127_75233_2 acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001872 314.0
HKD2_k127_75233_3 Glutathione S-transferase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003458 268.0
HKD2_k127_75233_4 Antibiotic biosynthesis monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000009599 205.0
HKD2_k127_75233_5 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000005641 167.0
HKD2_k127_75233_6 Pyruvate dehydrogenase - - - 0.000001145 51.0
HKD2_k127_765403_0 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955,K00956 - 2.7.1.25,2.7.7.4 3.32e-302 932.0
HKD2_k127_765403_1 COG0477 Permeases of the major facilitator superfamily K16211 - - 1.185e-252 788.0
HKD2_k127_765403_2 COG1609 Transcriptional regulators - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001975 476.0
HKD2_k127_765403_3 3'-Phosphoadenosine 5'-phosphosulfate (PAPS) 3'-phosphatase K01082 - 3.1.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002756 339.0
HKD2_k127_7698434_0 Belongs to the MIP aquaporin (TC 1.A.8) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 301.0
HKD2_k127_7698434_1 Erythromycin esterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 291.0
HKD2_k127_7698434_2 Low molecular weight phosphatase family K03741 - 1.20.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001727 255.0
HKD2_k127_7698434_3 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.00000000000000000000000000000000000000002318 158.0
HKD2_k127_7740401_0 Belongs to the GMC oxidoreductase family - - - 8.484e-278 861.0
HKD2_k127_7740401_1 Major Facilitator Superfamily - - - 4.045e-235 741.0
HKD2_k127_7740401_10 TonB dependent receptor - - - 0.00000000000000000000000000000000000000000000000000000004845 197.0
HKD2_k127_7740401_11 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000001551 183.0
HKD2_k127_7740401_12 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.00000000000000000000000000000000000000000000000003287 185.0
HKD2_k127_7740401_13 - - - - 0.00000000000000000000000000000000000000000007738 163.0
HKD2_k127_7740401_14 - - - - 0.00000000000000000000000000000000000000007326 170.0
HKD2_k127_7740401_2 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 5.069e-219 685.0
HKD2_k127_7740401_3 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 - 2.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 501.0
HKD2_k127_7740401_4 sterol desaturase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 494.0
HKD2_k127_7740401_5 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007793 449.0
HKD2_k127_7740401_6 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004954 385.0
HKD2_k127_7740401_7 COG0861 Membrane protein TerC, possibly involved in tellurium resistance - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 388.0
HKD2_k127_7740401_8 Cold shock K03704 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 381.0
HKD2_k127_7740401_9 Belongs to the ompA family - - - 0.000000000000000000000000000000000000000000000000000000000000000000001646 235.0
HKD2_k127_7785254_0 synthetase K01897 - 6.2.1.3 1.884e-307 958.0
HKD2_k127_7785254_1 gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 3.019e-233 735.0
HKD2_k127_7785254_2 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003983 563.0
HKD2_k127_7785254_3 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008154 544.0
HKD2_k127_7785254_4 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002767 521.0
HKD2_k127_7785254_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002584 276.0
HKD2_k127_7785254_6 PFAM CHAD domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000112 256.0
HKD2_k127_7785254_8 MerC mercury resistance protein - - - 0.000000000000000000000000000000000000001102 151.0
HKD2_k127_7785254_9 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000001288 150.0
HKD2_k127_7808463_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 8.191e-195 610.0
HKD2_k127_7808463_1 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002837 563.0
HKD2_k127_7808463_2 epimerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005968 421.0
HKD2_k127_7808463_3 Peptidase family M23 - - - 0.0000000000000000000000003871 105.0
HKD2_k127_7808463_5 - - - - 0.00008544 47.0
HKD2_k127_7824800_0 receptor K02014 - - 7.852e-280 878.0
HKD2_k127_7824800_1 cystathionine beta-lyase K01760 - 4.4.1.8 1.576e-198 629.0
HKD2_k127_7824800_10 - - - - 0.0000000000000000000000000000000000000001061 167.0
HKD2_k127_7824800_11 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000001358 142.0
HKD2_k127_7824800_2 acyl-CoA dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001027 512.0
HKD2_k127_7824800_3 Catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds K01011 - 2.8.1.1,2.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008526 449.0
HKD2_k127_7824800_4 Adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001296 418.0
HKD2_k127_7824800_5 Belongs to the precorrin methyltransferase family K02303 - 2.1.1.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000276 364.0
HKD2_k127_7824800_6 mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 334.0
HKD2_k127_7824800_7 Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily K09457 - 1.7.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 297.0
HKD2_k127_7824800_8 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000009838 231.0
HKD2_k127_7824800_9 Adenylate cyclase - - - 0.0000000000000000000000000000000000000000213 177.0
HKD2_k127_783066_0 Belongs to the helicase family. UvrD subfamily K16898 - 3.6.4.12 0.0 1390.0
HKD2_k127_783066_1 helicase K16899 - 3.6.4.12 0.0 1330.0
HKD2_k127_783066_10 Inositol monophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 384.0
HKD2_k127_783066_11 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00992 - 2.7.7.99 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008139 380.0
HKD2_k127_783066_12 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 387.0
HKD2_k127_783066_13 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006083 287.0
HKD2_k127_783066_14 ATPase or kinase K06925 - - 0.0000000000000000000000000000000000000000000000000000000000000001045 226.0
HKD2_k127_783066_15 Belongs to the thioredoxin family K03671 - - 0.000000000000000000000000000000000000000000000000000006191 191.0
HKD2_k127_783066_16 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000002601 168.0
HKD2_k127_783066_2 PAS fold - - - 0.0 1131.0
HKD2_k127_783066_3 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 6.966e-283 872.0
HKD2_k127_783066_4 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 2.263e-225 702.0
HKD2_k127_783066_5 COG0332 3-oxoacyl- acyl-carrier-protein synthase III K16872 - 2.3.1.207 3.289e-197 619.0
HKD2_k127_783066_6 Phosphotransferase K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002799 520.0
HKD2_k127_783066_7 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 443.0
HKD2_k127_783066_8 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 443.0
HKD2_k127_783066_9 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007299 411.0
HKD2_k127_7835015_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1566.0
HKD2_k127_7835015_1 Histidine kinase K13587 - 2.7.13.3 0.0 1147.0
HKD2_k127_7835015_10 Methyltransferase small domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 300.0
HKD2_k127_7835015_11 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005369 284.0
HKD2_k127_7835015_12 response regulator K13589 - - 0.000000000000000000000000000000000000000000000000000000000009288 209.0
HKD2_k127_7835015_13 protein conserved in bacteria K09928 - - 0.000000000000000000000000000000000000000000000000000001742 202.0
HKD2_k127_7835015_14 protein conserved in bacteria K09928 - - 0.00000000000000000000000000000000000000000000006171 181.0
HKD2_k127_7835015_15 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.00000000000000000000000000000000000003935 144.0
HKD2_k127_7835015_2 Elongation factor G, domain IV K02355 - - 2.35e-294 924.0
HKD2_k127_7835015_3 Belongs to the isocitrate and isopropylmalate dehydrogenases family K00031 - 1.1.1.42 3.134e-251 779.0
HKD2_k127_7835015_4 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08309 - - 3.164e-247 781.0
HKD2_k127_7835015_5 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 2.554e-230 726.0
HKD2_k127_7835015_6 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 6.205e-205 640.0
HKD2_k127_7835015_7 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 532.0
HKD2_k127_7835015_8 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 417.0
HKD2_k127_7835015_9 Glycosyltransferase family 87 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008113 356.0
HKD2_k127_78660_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 1.948e-312 966.0
HKD2_k127_78660_1 acyl-CoA dehydrogenase K20035 - - 5.98e-265 823.0
HKD2_k127_78660_10 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001626 418.0
HKD2_k127_78660_11 ATPase (AAA superfamily) K06923 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004072 398.0
HKD2_k127_78660_12 dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008631 368.0
HKD2_k127_78660_13 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007766 367.0
HKD2_k127_78660_14 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001259 307.0
HKD2_k127_78660_15 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006837 286.0
HKD2_k127_78660_16 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007836 288.0
HKD2_k127_78660_17 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001997 281.0
HKD2_k127_78660_18 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001313 256.0
HKD2_k127_78660_19 Thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001242 245.0
HKD2_k127_78660_2 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 9.51e-258 796.0
HKD2_k127_78660_20 GAF domain-containing protein K08968 - 1.8.4.14 0.0000000000000000000000000000000000000000000000000000000000000000000000381 243.0
HKD2_k127_78660_21 membrane K08973 - - 0.00000000000000000000000000000000000000000000000000000000000000000001724 239.0
HKD2_k127_78660_22 PTS IIA-like nitrogen-regulatory protein PtsN K02806 - - 0.0000000000000000000000000000000000000000000000000000000000000007911 223.0
HKD2_k127_78660_23 COG3773 Cell wall hydrolyses involved in spore germination - - - 0.000000000000000000000000000000000000000000000000000000000001674 216.0
HKD2_k127_78660_24 Ferredoxin - - - 0.0000000000000000000000000000000000000000000000000000000006017 209.0
HKD2_k127_78660_25 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000001568 192.0
HKD2_k127_78660_26 CBS domain - - - 0.0000000000000000000000000000000000000000000000000004014 193.0
HKD2_k127_78660_27 Belongs to the HesB IscA family - - - 0.000000000000000000000000000000000000000000000008882 175.0
HKD2_k127_78660_28 Protein of unknown function (DUF2497) K09991 - - 0.0000000000000000000000000000000000000000008787 160.0
HKD2_k127_78660_29 Thioesterase-like superfamily K07107 - - 0.000000000000000000000000000000000000000004889 158.0
HKD2_k127_78660_3 acyl-CoA dehydrogenase K00255 - 1.3.8.8 2.068e-239 745.0
HKD2_k127_78660_30 Protein of unknown function (DUF1491) - - - 0.000000000000000000000000000000000008634 140.0
HKD2_k127_78660_31 - - - - 0.00000000000000000000000000000002081 127.0
HKD2_k127_78660_4 sorbosone - - - 4.462e-203 642.0
HKD2_k127_78660_5 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004093 572.0
HKD2_k127_78660_6 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004603 567.0
HKD2_k127_78660_7 exodeoxyribonuclease III K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 485.0
HKD2_k127_78660_8 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002875 454.0
HKD2_k127_78660_9 Chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 449.0
HKD2_k127_7873066_0 Ammonium Transporter K03320 - - 5.624e-204 647.0
HKD2_k127_7873066_1 endonuclease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009076 350.0
HKD2_k127_7873066_2 Pfam:Pyridox_oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004957 285.0
HKD2_k127_7873066_3 Epimerase dehydratase K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000007094 258.0
HKD2_k127_7873066_4 Belongs to the P(II) protein family K04752 - - 0.000000000000000000000000000000000000000000000000000000000008301 209.0
HKD2_k127_7873066_5 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 0.000000000000000000000000000000000000000000000000000001538 191.0
HKD2_k127_7873066_6 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000001542 164.0
HKD2_k127_787790_0 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003586 464.0
HKD2_k127_787790_1 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 357.0
HKD2_k127_787790_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002731 352.0
HKD2_k127_787790_3 protein conserved in bacteria K09973 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002343 274.0
HKD2_k127_787790_4 TraB family K09973 - - 0.000000000000000000000000000000000000000000000000000000000000000009767 237.0
HKD2_k127_787790_5 Peptidase family S41 - - - 0.00000000000000000000000000000000000000000003447 167.0
HKD2_k127_7912420_0 Catalyzes the conversion of feruloyl-CoA to vanillin and acetyl-CoA K18383 - 4.1.2.41,4.2.1.101 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008029 540.0
HKD2_k127_7912420_1 NmrA-like family K19267 - 1.6.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 486.0
HKD2_k127_7912420_2 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006856 393.0
HKD2_k127_7912420_3 dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006333 386.0
HKD2_k127_7912420_4 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007665 299.0
HKD2_k127_7912420_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000004677 155.0
HKD2_k127_7912630_0 DNA polymerase K02337 - 2.7.7.7 0.0 1705.0
HKD2_k127_7912630_1 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 0.0 1023.0
HKD2_k127_7912630_10 Yip1 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003751 397.0
HKD2_k127_7912630_11 LexA-binding, inner membrane-associated putative hydrolase K07038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 391.0
HKD2_k127_7912630_12 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 381.0
HKD2_k127_7912630_13 N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002018 364.0
HKD2_k127_7912630_14 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 350.0
HKD2_k127_7912630_15 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 332.0
HKD2_k127_7912630_16 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005084 295.0
HKD2_k127_7912630_17 May be involved in the biosynthesis of molybdopterin K03638 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 294.0
HKD2_k127_7912630_18 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003 272.0
HKD2_k127_7912630_19 uracil-DNA glycosylase K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000005447 243.0
HKD2_k127_7912630_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K20034 - 6.2.1.44 6.779e-284 884.0
HKD2_k127_7912630_20 Domain of unknown function (DUF1330) - - - 0.00000000000000000000000000000000000000000000000000001059 194.0
HKD2_k127_7912630_21 Acid phosphatase homologues K19302 - 3.6.1.27 0.000000000000000000000000000000000000000000000000002513 191.0
HKD2_k127_7912630_22 Pilus assembly protein PilZ - - - 0.000000000000000000000000000000000000000000003001 168.0
HKD2_k127_7912630_3 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 2.79e-280 873.0
HKD2_k127_7912630_4 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 2.268e-267 829.0
HKD2_k127_7912630_5 Belongs to the DNA photolyase family K01669 - 4.1.99.3 8.191e-229 717.0
HKD2_k127_7912630_6 ABC-type transport system, involved in lipoprotein release, permease component K09808 - - 1.538e-202 637.0
HKD2_k127_7912630_7 DNA repair photolyase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000255 578.0
HKD2_k127_7912630_8 synthase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002602 558.0
HKD2_k127_7912630_9 Belongs to the IlvD Edd family K01687 - 4.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005023 432.0
HKD2_k127_7919930_0 TonB dependent receptor K16090 - - 7.09e-244 771.0
HKD2_k127_7919930_1 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 591.0
HKD2_k127_7919930_10 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004164 279.0
HKD2_k127_7919930_11 - - - - 0.0000000000000000000000000000000000000000000000000000000002416 217.0
HKD2_k127_7919930_12 Arsenate reductase K00537 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000007061 199.0
HKD2_k127_7919930_13 receptor K02014 - - 0.0000000000000007307 77.0
HKD2_k127_7919930_2 NADH flavin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003489 578.0
HKD2_k127_7919930_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 575.0
HKD2_k127_7919930_4 Aldolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 427.0
HKD2_k127_7919930_5 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 385.0
HKD2_k127_7919930_6 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002528 366.0
HKD2_k127_7919930_7 Methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000489 361.0
HKD2_k127_7919930_8 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000964 351.0
HKD2_k127_7919930_9 aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006817 295.0
HKD2_k127_7940766_0 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 506.0
HKD2_k127_7940766_1 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003279 495.0
HKD2_k127_7940766_2 KR domain K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000294 363.0
HKD2_k127_7940766_3 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001104 319.0
HKD2_k127_7940766_4 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001007 304.0
HKD2_k127_7940766_5 Belongs to the UPF0276 family K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001162 282.0
HKD2_k127_7940766_6 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002083 251.0
HKD2_k127_7940766_7 Sulphur transport K07112,K19168 - - 0.0000000000000000000000000000000000000000000000004742 186.0
HKD2_k127_7940766_8 Cupin domain - - - 0.00000000000000000000000000000000000000000003616 168.0
HKD2_k127_7940766_9 Predicted integral membrane protein (DUF2282) - - - 0.000000000000000000000000001307 119.0
HKD2_k127_8258521_0 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005072 486.0
HKD2_k127_8258521_1 N-acetylmuramoyl-L-alanine amidase K01447 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 399.0
HKD2_k127_8258521_2 Histidine phosphotransferase C-terminal domain K13588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 323.0
HKD2_k127_8258521_3 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.000000000000000000000000000000000005769 146.0
HKD2_k127_8258521_5 RNA polymerase sigma K03089 - - 0.0000000000001549 73.0
HKD2_k127_8291990_0 P-type ATPase K17686 - 3.6.3.54 0.0 1239.0
HKD2_k127_8291990_1 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 366.0
HKD2_k127_8291990_2 but high domain identity with epimerases and phenazine biosynthesis-like protein, PhzC PhzF which is involved in dimerisation of two 2,3- dihydro-3-oxo-anthranilic acid molecules to create Pca by P. fluorescens K06998 - 5.3.3.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 311.0
HKD2_k127_8291990_3 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003011 301.0
HKD2_k127_8291990_4 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000001653 261.0
HKD2_k127_8291990_5 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005915 248.0
HKD2_k127_8291990_6 MerR family transcriptional regulator K19591 - - 0.000000000000000000000000000000000000000000000000000003368 199.0
HKD2_k127_8291990_7 Periplasmic protein TonB, links inner and outer membranes K03832 - - 0.00000000000000000000000000000032 139.0
HKD2_k127_8291990_8 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000003314 115.0
HKD2_k127_8291990_9 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.00000000000001576 74.0
HKD2_k127_8434481_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0 1219.0
HKD2_k127_8434481_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 0.0 1205.0
HKD2_k127_8434481_10 membrane transporter protein K07090 - - 0.00000000000000000000000000000000000000000000000000000000000000000000003242 249.0
HKD2_k127_8434481_11 Lipopolysaccharide-assembly K03643 - - 0.000000000000000000000000000000000000000000000000000000000000001174 234.0
HKD2_k127_8434481_2 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1013.0
HKD2_k127_8434481_3 AMP-binding enzyme C-terminal domain K00666 - - 3.982e-256 797.0
HKD2_k127_8434481_4 Peptidase, M28 - - - 9.373e-233 761.0
HKD2_k127_8434481_5 Belongs to the agmatine deiminase family K10536 - 3.5.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001871 553.0
HKD2_k127_8434481_6 DNA polymerase III K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 454.0
HKD2_k127_8434481_7 protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000501 394.0
HKD2_k127_8434481_8 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006552 275.0
HKD2_k127_8434481_9 Alkyl hydroperoxide reductase K03564 - 1.11.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000003706 267.0
HKD2_k127_8809858_0 Glycine dehydrogenase (aminomethyl-transferring) K00283 - 1.4.4.2 1.279e-278 865.0
HKD2_k127_8809858_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00282 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005521 565.0
HKD2_k127_8809858_2 Domain of unknown function (DUF4281) - - - 0.000000000000000000000000000000000000000000000000000001374 195.0
HKD2_k127_8809858_3 Entericidin EcnA/B family - - - 0.00000000008417 63.0
HKD2_k127_8882764_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 1.015e-249 776.0
HKD2_k127_8882764_1 involved in chromosome partitioning K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001068 425.0
HKD2_k127_8882764_2 Protein of unknown function (DUF418) K07148 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006837 396.0
HKD2_k127_8882764_3 FOG TPR repeat, SEL1 subfamily K07126 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 339.0
HKD2_k127_8882764_4 - - - - 0.0000000004652 69.0
HKD2_k127_9035306_0 Glycosyl-hydrolase 97 C-terminal, oligomerisation K01187 - 3.2.1.20 0.0 1185.0
HKD2_k127_9035306_1 Thioesterase superfamily K19222 - 3.1.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000001013 244.0
HKD2_k127_9035306_2 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.000000000000000000000000000000000000001467 149.0
HKD2_k127_9035306_3 Alpha-amylase domain K01187 - 3.2.1.20 0.0000000000000000000000003556 107.0
HKD2_k127_9035306_4 membrane - - - 0.000000004353 59.0
HKD2_k127_9071820_0 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 1.821e-218 691.0
HKD2_k127_9071820_1 protein conserved in bacteria K21470 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007398 546.0
HKD2_k127_9071820_2 of the drug metabolite transporter (DMT) superfamily K15270 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 301.0
HKD2_k127_9071820_3 L,D-transpeptidase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003705 289.0
HKD2_k127_9071820_4 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001278 273.0
HKD2_k127_9071820_5 Acetyltransferase (GNAT) domain K03829 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006803 248.0
HKD2_k127_9071820_6 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002794 231.0
HKD2_k127_9071820_7 gag-polyprotein putative aspartyl protease K06985 - - 0.00000000000000000000000000000000003916 140.0
HKD2_k127_9071820_8 Asparaginase K13051 - 3.4.19.5 0.0000139 52.0
HKD2_k127_91109_0 acyl-CoA dehydrogenase - - - 2.007e-310 959.0
HKD2_k127_91109_1 Von Willebrand factor A K09989 - - 3.841e-243 752.0
HKD2_k127_91109_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006783 261.0
HKD2_k127_91109_11 methyl-accepting chemotaxis protein K03406 - - 0.000000000000000000000000000000000000000000000000000000000000000000004528 239.0
HKD2_k127_91109_12 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000117 212.0
HKD2_k127_91109_13 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496 - 3.5.4.19 0.0000000000000000000000000000000000000000000000000000002713 197.0
HKD2_k127_91109_14 PilZ domain - - - 0.00000000000000000000000000000000000000000000001244 176.0
HKD2_k127_91109_15 - - - - 0.000000000000000000000000000000002155 137.0
HKD2_k127_91109_16 Competence protein - - - 0.000000000000000000003628 95.0
HKD2_k127_91109_2 Protein of unknown function (DUF1343) - - - 1.819e-235 733.0
HKD2_k127_91109_3 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 3.44e-208 657.0
HKD2_k127_91109_4 methyl-accepting chemotaxis protein K03406 - - 8.103e-198 626.0
HKD2_k127_91109_5 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005143 572.0
HKD2_k127_91109_6 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005699 529.0
HKD2_k127_91109_7 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001797 441.0
HKD2_k127_91109_8 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 325.0
HKD2_k127_91109_9 dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002803 278.0
HKD2_k127_9137612_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 2.317e-261 814.0
HKD2_k127_9137612_1 Dehydrogenase K00101,K15054 - 1.1.2.3,1.1.99.31 3.272e-206 646.0
HKD2_k127_9137612_2 M42 glutamyl aminopeptidase - - - 3.001e-204 646.0
HKD2_k127_9137612_3 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00019 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 393.0
HKD2_k127_9137612_4 metalloprotease K07054 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006566 277.0
HKD2_k127_9137612_5 metalloprotease K07054 - - 0.000000000000001473 85.0
HKD2_k127_9137612_6 Antirepressor regulating drug resistance - - - 0.00000000000000374 84.0
HKD2_k127_9137612_7 metalloprotease K07054 - - 0.0000000000002318 74.0
HKD2_k127_9154527_0 DEAD DEAH box helicase K11927 - 3.6.4.13 3.109e-217 685.0
HKD2_k127_9154527_1 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005871 500.0
HKD2_k127_9154527_2 DNA repair protein MmcB-like - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005802 252.0
HKD2_k127_9220034_0 COG1629 Outer membrane receptor proteins, mostly Fe transport K02014 - - 0.0 1225.0
HKD2_k127_9220034_1 COG1609 Transcriptional regulators - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004425 536.0
HKD2_k127_9220034_2 Tryptophan halogenase K14266 - 1.14.19.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 377.0
HKD2_k127_9225587_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1335.0
HKD2_k127_9225587_1 Polysaccharide biosynthesis protein - - - 1.886e-206 660.0
HKD2_k127_9225587_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 554.0
HKD2_k127_9225587_3 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001522 467.0
HKD2_k127_9225587_4 CAAX protease self-immunity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009262 273.0
HKD2_k127_9225587_5 rRNA binding - - - 0.00000000000000000000000000000000000000000000000000000000000007606 218.0
HKD2_k127_9225587_6 nitrite transmembrane transporter activity K08177 - - 0.000000000000000000000000000000000000000000000002839 183.0
HKD2_k127_9225587_7 Protein of unknown function (DUF3617) - - - 0.0000000000000000000000000000000001364 139.0
HKD2_k127_9227319_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 0.0 1345.0
HKD2_k127_9227319_1 Polynucleotide adenylyltransferase K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 543.0
HKD2_k127_9227319_10 Ferredoxin K04755 - - 0.00000000000000000000000000000000000000000000000007496 179.0
HKD2_k127_9227319_11 Belongs to the N(4) N(6)-methyltransferase family K13581 - 2.1.1.72 0.000000000003663 67.0
HKD2_k127_9227319_2 glucose sorbosone - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000035 538.0
HKD2_k127_9227319_3 overlaps another CDS with the same product name K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000534 491.0
HKD2_k127_9227319_4 overlaps another CDS with the same product name K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007246 466.0
HKD2_k127_9227319_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001639 316.0
HKD2_k127_9227319_6 Acetyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 299.0
HKD2_k127_9227319_7 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001573 289.0
HKD2_k127_9227319_8 Nudix hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001521 282.0
HKD2_k127_9227319_9 protein conserved in bacteria K09986 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001022 263.0
HKD2_k127_9236708_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0 1094.0
HKD2_k127_9236708_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 3.067e-211 669.0
HKD2_k127_9236708_2 Protein of unknown function (DUF3667) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 396.0
HKD2_k127_9236708_3 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002363 336.0
HKD2_k127_9236708_4 Domain of unknown function (DUF4136) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009591 318.0
HKD2_k127_9236708_5 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000009771 253.0
HKD2_k127_9236708_6 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000000000000000000000000000000000000000000001369 198.0
HKD2_k127_9236708_7 - - - - 0.000000000000000000000000000000000000000001041 171.0
HKD2_k127_9248080_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 481.0
HKD2_k127_9248080_1 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001997 322.0
HKD2_k127_9248080_2 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000000000000000000000000002984 218.0
HKD2_k127_9340207_0 CHAT domain - - - 1.665e-320 1008.0
HKD2_k127_9340207_1 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 1.828e-204 650.0
HKD2_k127_9340373_0 protein conserved in bacteria K09919 - - 6.848e-194 612.0
HKD2_k127_9340373_1 ABC-type oligopeptide transport system, periplasmic component K02035,K15580 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001169 531.0
HKD2_k127_9340373_2 glycerophosphoryl diester phosphodiesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 366.0
HKD2_k127_9340373_3 Male sterility protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 318.0
HKD2_k127_9340373_4 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001448 261.0
HKD2_k127_9340373_5 translation initiation inhibitor, yjgF family - - - 0.0000000000000000000000000000000000000000000001284 174.0
HKD2_k127_9340373_6 FOG TPR repeat, SEL1 subfamily K07126 - - 0.0000000000000000000000000000000000000000006317 166.0
HKD2_k127_9340373_7 PilZ domain - - - 0.0000000000000000000000000000000000002615 145.0
HKD2_k127_9340373_8 UMP catabolic process - - - 0.0000000000002015 70.0
HKD2_k127_9407701_0 Flp pilus assembly protein, ATPase CpaE K02282 - - 1.361e-213 669.0
HKD2_k127_9407701_1 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) K16171 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002094 558.0
HKD2_k127_9407701_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000004983 178.0
HKD2_k127_9407701_11 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000009535 170.0
HKD2_k127_9407701_2 type II secretion system protein K12511 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001737 489.0
HKD2_k127_9407701_3 pilus assembly protein TadB K12510 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 476.0
HKD2_k127_9407701_4 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007484 453.0
HKD2_k127_9407701_5 Belongs to the GSP D family K02280 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000247 436.0
HKD2_k127_9407701_6 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000077 428.0
HKD2_k127_9407701_7 Transcriptional regulator, TetR, C-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 319.0
HKD2_k127_9407701_8 Pilus assembly protein CpaD K02281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001834 282.0
HKD2_k127_9407701_9 maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000009964 261.0
HKD2_k127_9524945_0 ATP-dependent helicase K03579 - 3.6.4.13 0.0 1165.0
HKD2_k127_9524945_1 Histidine kinase - - - 3.379e-224 702.0
HKD2_k127_9524945_2 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 567.0
HKD2_k127_9524945_3 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003634 479.0
HKD2_k127_9524945_4 Phosphoenolpyruvate phosphomutase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003092 322.0
HKD2_k127_9524945_5 - - - - 0.000000000000000000000000000000000000000000000000000000000001458 222.0
HKD2_k127_9524945_6 ETC complex I subunit - - - 0.0000000000000000000000000000000000000000009248 160.0
HKD2_k127_9524945_7 chorismate mutase K04092 - 5.4.99.5 0.0000000000000000000000000000000000000008352 154.0
HKD2_k127_9682110_0 Osmosensitive K channel K07646 - 2.7.13.3 1.665e-302 942.0
HKD2_k127_9682110_1 COG2801 Transposase and inactivated derivatives - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 364.0
HKD2_k127_9682110_2 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002181 356.0
HKD2_k127_9682110_3 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003644 351.0
HKD2_k127_9682110_4 - - - - 0.0000002875 54.0
HKD2_k127_9705352_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0 1112.0
HKD2_k127_9705352_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 4.879e-277 863.0
HKD2_k127_9705352_10 Belongs to the CarB family K01955 - 6.3.5.5 0.00000000000000000000000001349 109.0
HKD2_k127_9705352_11 - - - - 0.000000000000000000001111 95.0
HKD2_k127_9705352_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 2.049e-247 770.0
HKD2_k127_9705352_3 Belongs to the CarA family K01956 - 6.3.5.5 1.067e-216 677.0
HKD2_k127_9705352_4 transporter K08369 - - 9.193e-214 676.0
HKD2_k127_9705352_5 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 389.0
HKD2_k127_9705352_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 380.0
HKD2_k127_9705352_7 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002036 266.0
HKD2_k127_9705352_8 Ribose 5-phosphate isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000003553 226.0
HKD2_k127_9705352_9 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000000000000000000000000000005274 225.0
HKD2_k127_9775443_0 FldA protein K16514 - 5.3.2.8 3.368e-195 612.0
HKD2_k127_9775443_1 LysR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008436 546.0
HKD2_k127_9775443_2 Hydrolase K10221 - 3.1.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001231 544.0
HKD2_k127_9775443_3 COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001722 507.0
HKD2_k127_9775443_4 Aldolase/RraA K10218 - 4.1.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003268 411.0
HKD2_k127_9775443_5 Domain of unknown function (DUF1932) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008281 314.0
HKD2_k127_9775443_6 SnoaL-like domain - - - 0.0000000000000000000000000000000000000000000000000000000002357 215.0
HKD2_k127_9775443_7 Membrane protein implicated in regulation of membrane protease activity K07340 - - 0.0000000000000000000000000000000000000000000000000000002264 198.0
HKD2_k127_9775443_9 Belongs to the ompA family - - - 0.000000000000000002648 96.0
HKD2_k127_9795607_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1310.0
HKD2_k127_9795607_1 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 416.0
HKD2_k127_9795607_10 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000003563 187.0
HKD2_k127_9795607_11 Protein of unknown function (DUF3617) - - - 0.000000000000000000000000000000000006408 145.0
HKD2_k127_9795607_12 Aminotransferase class-V - - - 0.0002699 44.0
HKD2_k127_9795607_13 - - - - 0.000488 48.0
HKD2_k127_9795607_2 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000209 371.0
HKD2_k127_9795607_3 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 304.0
HKD2_k127_9795607_4 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002359 297.0
HKD2_k127_9795607_5 nitrite transmembrane transporter activity K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002518 307.0
HKD2_k127_9795607_6 Extensin-like protein C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005459 288.0
HKD2_k127_9795607_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001611 284.0
HKD2_k127_9795607_8 CAAX protease self-immunity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001121 272.0
HKD2_k127_9795607_9 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000004876 212.0
HKD2_k127_9837668_0 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 0.0 1110.0
HKD2_k127_9837668_1 Asparagine synthase K01953 - 6.3.5.4 5.953e-321 992.0
HKD2_k127_9837668_10 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 484.0
HKD2_k127_9837668_11 Chain-length determining protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002594 469.0
HKD2_k127_9837668_12 Glycosyl transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 464.0
HKD2_k127_9837668_13 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 458.0
HKD2_k127_9837668_14 involved in chromosome partitioning - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000559 404.0
HKD2_k127_9837668_15 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000616 388.0
HKD2_k127_9837668_16 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 321.0
HKD2_k127_9837668_17 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004083 277.0
HKD2_k127_9837668_18 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002003 271.0
HKD2_k127_9837668_19 protein, possibly involved in aromatic compounds catabolism - - - 0.0000000000000000000000000000000000000000000000000007236 187.0
HKD2_k127_9837668_2 TonB dependent receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000311 629.0
HKD2_k127_9837668_20 Protein of unknown function (DUF4242) - - - 0.000000000000000000000000004002 115.0
HKD2_k127_9837668_3 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009925 597.0
HKD2_k127_9837668_4 AFG1 family ATPase K06916 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000589 585.0
HKD2_k127_9837668_5 Protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004999 582.0
HKD2_k127_9837668_6 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000284 564.0
HKD2_k127_9837668_7 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 535.0
HKD2_k127_9837668_8 Type II secretory pathway, component ExeA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001323 489.0
HKD2_k127_9837668_9 polysaccharide deacetylase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005318 475.0
HKD2_k127_9847033_0 Transporter - - - 8.745e-305 946.0
HKD2_k127_9847033_1 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000001381 153.0
HKD2_k127_9847033_2 - - - - 0.00000000000000000000000005211 111.0
HKD2_k127_9847033_3 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000001743 78.0
HKD2_k127_9863945_0 MotA TolQ ExbB proton channel K03562 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001146 310.0
HKD2_k127_9863945_1 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001307 246.0
HKD2_k127_9863945_2 COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - 0.00000000000000000000000000000000000000000000000000000000000000004253 226.0
HKD2_k127_9863945_3 thioesterase K07107 - - 0.0000000000000000000000000000000000000000000000000000000000002324 215.0
HKD2_k127_9863945_4 Phosphoribosyl-ATP K01523 - 3.6.1.31 0.0000000000000000000000000000000000007617 141.0