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Overview

ID MAG01799
Name HKD2_bin.46
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family SG8-39
Genus DAHVFK01
Species
Assembly information
Completeness (%) 72.41
Contamination (%) 0.23
GC content (%) 68.0
N50 (bp) 13,400
Genome size (bp) 2,098,419

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2167

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10024611_0 Pirin C-terminal cupin domain K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 391.0
HKD2_k127_10024611_1 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004521 374.0
HKD2_k127_10024611_2 COG0457 FOG TPR repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 345.0
HKD2_k127_10024611_3 Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity K01118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003566 260.0
HKD2_k127_10024611_4 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000008491 242.0
HKD2_k127_10024611_5 Creatinine amidohydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000004066 226.0
HKD2_k127_10024611_6 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000001266 187.0
HKD2_k127_10024611_7 PFAM DoxX K15977 - - 0.0000000000000000000000000000000000001043 156.0
HKD2_k127_10024611_8 - - - - 0.00000000000000000000000000000003381 133.0
HKD2_k127_10126948_0 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 6.269e-280 869.0
HKD2_k127_10126948_1 Aldehyde dehydrogenase K00128,K00130 - 1.2.1.3,1.2.1.8 2.27e-210 663.0
HKD2_k127_10126948_10 mechanosensitive ion channel K22044 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 355.0
HKD2_k127_10126948_11 ABC transporter substrate-binding protein K02016 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000158 356.0
HKD2_k127_10126948_12 Belongs to the GST superfamily K11209 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003102 336.0
HKD2_k127_10126948_13 KR domain K00046 - 1.1.1.69 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 322.0
HKD2_k127_10126948_14 helix_turn_helix isocitrate lyase regulation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 319.0
HKD2_k127_10126948_15 KR domain K00076,K08081 - 1.1.1.159,1.1.1.206 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 316.0
HKD2_k127_10126948_16 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 310.0
HKD2_k127_10126948_17 haloacid dehalogenase-like hydrolase K02203 - 2.7.1.39,3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004021 282.0
HKD2_k127_10126948_18 short-chain dehydrogenase reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002908 277.0
HKD2_k127_10126948_19 Enoyl-CoA hydratase/isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000004642 244.0
HKD2_k127_10126948_2 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00001,K00121 - 1.1.1.1,1.1.1.284 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003944 527.0
HKD2_k127_10126948_20 PFAM L-carnitine dehydratase bile acid-inducible protein F K01796 - 5.1.99.4 0.000000000000000000000000000000000000000000000000000000003618 211.0
HKD2_k127_10126948_21 RDD family - - - 0.000000000000000000000000000000000000009939 149.0
HKD2_k127_10126948_22 Thioesterase superfamily protein - - - 0.0000000000000000000001439 109.0
HKD2_k127_10126948_23 Phosphopantetheine attachment site - - - 0.0000000000000000000003461 109.0
HKD2_k127_10126948_24 Domain of unknown function (DUF4124) - - - 0.000001799 55.0
HKD2_k127_10126948_3 Transketolase, pyrimidine binding domain K00162,K21417 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 527.0
HKD2_k127_10126948_4 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008194 521.0
HKD2_k127_10126948_5 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K21416 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004331 497.0
HKD2_k127_10126948_6 e3 binding domain K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 453.0
HKD2_k127_10126948_7 13-prostaglandin reductase activity K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 395.0
HKD2_k127_10126948_8 Acyl-CoA dehydrogenase, middle domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 389.0
HKD2_k127_10126948_9 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000181 358.0
HKD2_k127_107150_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 3.365e-312 964.0
HKD2_k127_107150_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 3.793e-270 856.0
HKD2_k127_107150_10 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 413.0
HKD2_k127_107150_11 malonyl CoA-acyl carrier protein transacylase K00645,K15355 - 2.3.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 392.0
HKD2_k127_107150_12 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001064 381.0
HKD2_k127_107150_13 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002009 367.0
HKD2_k127_107150_14 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K00997,K01207 - 2.7.8.7,3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002153 356.0
HKD2_k127_107150_15 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 347.0
HKD2_k127_107150_16 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 336.0
HKD2_k127_107150_17 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 313.0
HKD2_k127_107150_18 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005576 302.0
HKD2_k127_107150_19 negative regulator of sigma E activity K03598 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002338 265.0
HKD2_k127_107150_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 1.16e-234 740.0
HKD2_k127_107150_20 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.000000000000000000000000000000000000000000000000000000000000000000000001285 250.0
HKD2_k127_107150_21 Involved in DNA repair and RecF pathway recombination K03584 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001198 249.0
HKD2_k127_107150_22 Haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000009401 248.0
HKD2_k127_107150_23 S-adenosylmethionine-dependent methyltransferase, YraL family K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000001124 243.0
HKD2_k127_107150_24 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.000000000000000000000000000000000000000000000000000000000000000002053 233.0
HKD2_k127_107150_25 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000000271 223.0
HKD2_k127_107150_26 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000008144 169.0
HKD2_k127_107150_27 Belongs to the ompA family - - - 0.000000000000000000000000000000000000007382 155.0
HKD2_k127_107150_28 FecR protein - - - 0.000000000000000000000000000000000000246 145.0
HKD2_k127_107150_29 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000000000009574 134.0
HKD2_k127_107150_3 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 1.618e-209 666.0
HKD2_k127_107150_30 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.000000000000000000000000000008465 123.0
HKD2_k127_107150_31 rieske 2fe-2s - - - 0.00000000000000000000000000001172 128.0
HKD2_k127_107150_32 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000000000009142 110.0
HKD2_k127_107150_33 Psort location Cytoplasmic, score 8.96 K07040 - - 0.0000000000000000000000002217 111.0
HKD2_k127_107150_34 Domain of unknown function (DUF4845) - - - 0.0000000000000000000000003836 108.0
HKD2_k127_107150_35 PFAM Anti sigma-E protein RseA family protein K03597 - - 0.00000000000000000000006438 106.0
HKD2_k127_107150_36 Glutaredoxin-like domain (DUF836) K00384 - 1.8.1.9 0.0000000000000000000005069 97.0
HKD2_k127_107150_37 Histidine kinase-like ATPase domain - - - 0.000000000000001962 84.0
HKD2_k127_107150_39 - - - - 0.000747 50.0
HKD2_k127_107150_4 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 1.331e-199 632.0
HKD2_k127_107150_5 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004265 563.0
HKD2_k127_107150_6 CHASE2 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 488.0
HKD2_k127_107150_7 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005094 440.0
HKD2_k127_107150_8 signal peptide peptidase K04773 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004756 428.0
HKD2_k127_107150_9 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004924 421.0
HKD2_k127_1310364_0 Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family K03455 - - 8.04e-219 697.0
HKD2_k127_1310364_1 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004503 439.0
HKD2_k127_1310364_2 Histidine kinase-like ATPases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008543 332.0
HKD2_k127_1310364_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000128 254.0
HKD2_k127_1310364_4 Prokaryotic N-terminal methylation motif - - - 0.000000000000000000000000000000000000000000000000000000000005418 214.0
HKD2_k127_1310364_5 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.00000000000000000000000000000000000000000000000000000003508 203.0
HKD2_k127_1319095_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.0 1142.0
HKD2_k127_1319095_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 2.44e-304 949.0
HKD2_k127_1319095_10 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000074 258.0
HKD2_k127_1319095_11 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene K03664 - - 0.00000000000000000000000000000000000000000000000000000000000000000002068 235.0
HKD2_k127_1319095_12 Cytidylyltransferase family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000000000000001967 206.0
HKD2_k127_1319095_13 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000000000000000000003908 199.0
HKD2_k127_1319095_14 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03437 - - 0.000000000000000000000000000000000000000000000000000004742 199.0
HKD2_k127_1319095_15 Belongs to the skp family K06142 - - 0.000000000000000000000000000000000000000000003783 176.0
HKD2_k127_1319095_16 Psort location Cytoplasmic, score 8.96 - - - 0.0000000000000000000000000000000000003388 147.0
HKD2_k127_1319095_17 Belongs to the UPF0125 (RnfH) family K09801 - - 0.00000000000000000741 92.0
HKD2_k127_1319095_18 Domain of unknown function (DUF4124) - - - 0.0000000000007718 76.0
HKD2_k127_1319095_2 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 2.206e-255 795.0
HKD2_k127_1319095_3 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 1.178e-241 754.0
HKD2_k127_1319095_4 zinc metalloprotease K11749 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 496.0
HKD2_k127_1319095_5 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009133 477.0
HKD2_k127_1319095_6 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 444.0
HKD2_k127_1319095_7 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD K02536 - 2.3.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000463 366.0
HKD2_k127_1319095_8 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005443 359.0
HKD2_k127_1319095_9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009621 331.0
HKD2_k127_1324467_0 2-methylcitrate dehydratase K01720 - 4.2.1.79 2.132e-255 799.0
HKD2_k127_1324467_1 Belongs to the citrate synthase family K01659 - 2.3.3.5 4.066e-198 626.0
HKD2_k127_1324467_10 Protein of unknown function (DUF3460) - - - 0.00000000006934 64.0
HKD2_k127_1324467_2 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 486.0
HKD2_k127_1324467_3 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate K01841,K03417 - 4.1.3.30,5.4.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 473.0
HKD2_k127_1324467_4 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004163 376.0
HKD2_k127_1324467_5 UTRA K03710 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005371 322.0
HKD2_k127_1324467_6 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007315 320.0
HKD2_k127_1324467_7 Thioredoxin-like - - - 0.00000000000000000000000000000000000000004403 158.0
HKD2_k127_1324467_8 Succinate dehydrogenase, hydrophobic K00242 - - 0.00000000000000000000000000000000000357 143.0
HKD2_k127_1324467_9 succinate dehydrogenase K00241 - - 0.0000000000000000000000000007599 121.0
HKD2_k127_1330210_0 UvrD/REP helicase N-terminal domain K03657 - 3.6.4.12 2.687e-296 921.0
HKD2_k127_1330210_1 Phage lysozyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009313 329.0
HKD2_k127_1330210_2 TIR domain - - - 0.00000000000000000000000000000000000000000000000000000000000001636 233.0
HKD2_k127_1330210_3 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000001688 179.0
HKD2_k127_1334124_0 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 1.658e-302 945.0
HKD2_k127_1334124_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 9.561e-268 841.0
HKD2_k127_1334124_2 Psort location Cytoplasmic, score 8.96 K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003721 401.0
HKD2_k127_1334124_3 Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage K00772 - 2.4.2.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000456 336.0
HKD2_k127_1334124_4 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000005746 269.0
HKD2_k127_1334124_5 DsrE/DsrF-like family - - - 0.0000000000000000000000000000000000000000000000000000000000000001355 222.0
HKD2_k127_1334124_6 Phosphoribosyl transferase domain K00760 - 2.4.2.8 0.00000000000000000000000000000000000000000000000000000000001598 217.0
HKD2_k127_1334124_7 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins - - - 0.000000499 52.0
HKD2_k127_136103_0 AMP-binding enzyme C-terminal domain K00666 - - 2.312e-283 878.0
HKD2_k127_136103_1 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454,K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005216 583.0
HKD2_k127_136103_10 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000446 231.0
HKD2_k127_136103_11 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000004457 218.0
HKD2_k127_136103_12 Protein of unknown function, DUF488 - - - 0.00000000000000000000000000000000000000000000000000000000008604 205.0
HKD2_k127_136103_13 PFAM DoxX family protein K15977 - - 0.0000000000000000000000000000000006604 136.0
HKD2_k127_136103_14 Uncharacterized ArCR, COG1888 K09732 - - 0.00000000000000000000021 99.0
HKD2_k127_136103_15 protein conserved in bacteria K09794 - - 0.0000000001248 69.0
HKD2_k127_136103_16 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000001485 63.0
HKD2_k127_136103_17 - - - - 0.0001286 52.0
HKD2_k127_136103_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002977 546.0
HKD2_k127_136103_3 Epoxide hydrolase N terminus K01253 - 3.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001188 505.0
HKD2_k127_136103_4 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 420.0
HKD2_k127_136103_5 P-aminobenzoate N-oxygenase AurF - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 420.0
HKD2_k127_136103_6 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004227 356.0
HKD2_k127_136103_7 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004678 321.0
HKD2_k127_136103_8 PFAM Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006496 315.0
HKD2_k127_136103_9 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009774 313.0
HKD2_k127_1364473_0 PFAM sigma-54 factor interaction domain-containing protein - - - 1.14e-199 651.0
HKD2_k127_1364473_1 Extracellular liganD-binding receptor K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001585 519.0
HKD2_k127_1364473_2 Belongs to the peptidase S1C family K04691,K04772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005595 463.0
HKD2_k127_1364473_3 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004693 438.0
HKD2_k127_1364473_4 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000835 431.0
HKD2_k127_1364473_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000227 435.0
HKD2_k127_1364473_6 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004328 425.0
HKD2_k127_1364473_7 PFAM ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003336 367.0
HKD2_k127_1364473_8 ATPases associated with a variety of cellular activities K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001597 361.0
HKD2_k127_1422776_0 Conserved TM helix - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001132 290.0
HKD2_k127_1422776_1 DNA-templated transcription, initiation K03088 - - 0.000000000000000000000000000000000000000000000001218 179.0
HKD2_k127_1422776_2 Putative zinc-finger - - - 0.000000000000000000000000000000000000001134 167.0
HKD2_k127_1422776_3 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000004515 145.0
HKD2_k127_1422776_4 Cupredoxin-like domain K02275 - 1.9.3.1 0.000000000000000000000000000000000667 133.0
HKD2_k127_1422776_5 Bacterial protein of unknown function (DUF883) - - - 0.0000000000000000000000007452 111.0
HKD2_k127_1422776_6 PFAM PsiF repeat protein - - - 0.00000000000000000008875 98.0
HKD2_k127_1422776_7 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.00000000000003236 77.0
HKD2_k127_1426767_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 2.573e-280 868.0
HKD2_k127_1426767_1 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 2.029e-226 726.0
HKD2_k127_1426767_2 COG1960 Acyl-CoA dehydrogenases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 521.0
HKD2_k127_1426767_3 enoyl-CoA hydratase K13766,K15312 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008916 309.0
HKD2_k127_1426767_4 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000004446 173.0
HKD2_k127_1426767_5 Belongs to the thiolase family K00626 - 2.3.1.9 0.00000000000000000000000000000000001043 136.0
HKD2_k127_1426767_6 thiolester hydrolase activity K17362 - - 0.0000000000000000000000000000003611 126.0
HKD2_k127_1457847_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 3e-323 1028.0
HKD2_k127_1457847_1 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 2.856e-219 696.0
HKD2_k127_1457847_10 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004904 260.0
HKD2_k127_1457847_11 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000000000003606 181.0
HKD2_k127_1457847_12 Protein of unknown function, DUF547 - - - 0.000000000000000000000000000000002571 142.0
HKD2_k127_1457847_13 Dehydroquinase class II - - - 0.000000000000000004262 85.0
HKD2_k127_1457847_14 protein conserved in bacteria - - - 0.00001716 56.0
HKD2_k127_1457847_2 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001684 443.0
HKD2_k127_1457847_3 Zn-dependent hydrolases of the beta-lactamase fold K13985 - 3.1.4.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 432.0
HKD2_k127_1457847_4 Taurine catabolism dioxygenase TauD, TfdA family K22303 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 357.0
HKD2_k127_1457847_5 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002562 348.0
HKD2_k127_1457847_6 Uncharacterised MFS-type transporter YbfB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003787 338.0
HKD2_k127_1457847_7 Zinc-binding dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007164 315.0
HKD2_k127_1457847_8 Thioesterase-like superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006292 328.0
HKD2_k127_1457847_9 Belongs to the enoyl-CoA hydratase isomerase family K01692 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 329.0
HKD2_k127_1471595_0 COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase K02031,K02032 - - 2.003e-226 723.0
HKD2_k127_1471595_1 Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 392.0
HKD2_k127_1471595_2 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K01947,K03525 - 2.7.1.33,6.3.4.15 0.000000000000000000000000000000000000000000000000000000000002364 220.0
HKD2_k127_1471595_3 BirA family transcriptional regulator, biotin operon repressor K03524 - 6.3.4.15 0.000000000000000000000000000000000000001562 161.0
HKD2_k127_1471595_4 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000014 136.0
HKD2_k127_1471595_5 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000009957 103.0
HKD2_k127_1471595_6 Peptidase S8 and S53 subtilisin kexin sedolisin - - - 0.0004583 52.0
HKD2_k127_1478987_0 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.837e-250 780.0
HKD2_k127_1478987_1 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 546.0
HKD2_k127_1478987_2 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 - 2.5.1.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 538.0
HKD2_k127_1478987_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000001629 232.0
HKD2_k127_1478987_4 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.000000000000000000000000000000000000000000000000000000000000000006783 234.0
HKD2_k127_1478987_5 Psort location CytoplasmicMembrane, score K03558 - - 0.00000000000000000000000000000001117 133.0
HKD2_k127_1478987_6 Sporulation related domain K03749 - - 0.0000000000006405 74.0
HKD2_k127_1597355_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.131e-288 894.0
HKD2_k127_1597355_1 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 4.174e-213 674.0
HKD2_k127_1597355_2 homoserine dehydrogenase - - - 1.985e-212 668.0
HKD2_k127_1597355_3 Belongs to the KdsA family K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 434.0
HKD2_k127_1597355_4 ATPase MipZ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000169 293.0
HKD2_k127_1597355_5 acyl-CoA dehydrogenase K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000006585 262.0
HKD2_k127_1597355_6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.00000000000000000000000001873 110.0
HKD2_k127_1597355_7 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000007962 67.0
HKD2_k127_16278_0 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002597 570.0
HKD2_k127_16278_1 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 485.0
HKD2_k127_16278_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000005734 221.0
HKD2_k127_16278_11 CBS domain containing protein - - - 0.0000000000000000000000000000000000000000000537 168.0
HKD2_k127_16278_12 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.0000000000000000000000000000000000003124 141.0
HKD2_k127_16278_13 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000003046 143.0
HKD2_k127_16278_14 - - - - 0.0000000000000000000000009877 108.0
HKD2_k127_16278_15 protein conserved in bacteria K09937 - - 0.0000000000000000007296 87.0
HKD2_k127_16278_16 PFAM 17 kDa surface antigen - - - 0.0004985 49.0
HKD2_k127_16278_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 424.0
HKD2_k127_16278_3 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 392.0
HKD2_k127_16278_4 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005423 385.0
HKD2_k127_16278_5 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 370.0
HKD2_k127_16278_6 abc transporter K02065 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000663 365.0
HKD2_k127_16278_7 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005655 308.0
HKD2_k127_16278_8 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases K00020,K00042 - 1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000192 239.0
HKD2_k127_16278_9 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001144 230.0
HKD2_k127_1627848_0 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 1.695e-199 629.0
HKD2_k127_1627848_1 phosphate starvation-inducible protein PhoH K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 472.0
HKD2_k127_1627848_2 CBS domain containing protein K06189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001818 394.0
HKD2_k127_1627848_3 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.0000000000000000000000000000000000000001701 154.0
HKD2_k127_1631692_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 0.0 1480.0
HKD2_k127_1631692_1 Malic enzyme K00029 - 1.1.1.40 2.406e-256 799.0
HKD2_k127_1631692_10 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.000000000000000000000000000000023 130.0
HKD2_k127_1631692_11 - K06950 - - 0.00000000001051 67.0
HKD2_k127_1631692_12 Protein of unknown function (DUF2442) - - - 0.0000000118 66.0
HKD2_k127_1631692_13 Histone H1-like nucleoprotein HC2 K11275 - - 0.00000008294 59.0
HKD2_k127_1631692_14 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.000006107 49.0
HKD2_k127_1631692_2 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 6.67e-211 659.0
HKD2_k127_1631692_3 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains K02667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 555.0
HKD2_k127_1631692_4 PFAM aminotransferase, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008493 440.0
HKD2_k127_1631692_5 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 430.0
HKD2_k127_1631692_6 ATPase histidine kinase DNA gyrase B HSP90 domain protein K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004899 404.0
HKD2_k127_1631692_7 N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD K03806 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000003708 244.0
HKD2_k127_1631692_8 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000000000000000000000002151 158.0
HKD2_k127_1631692_9 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - 0.000000000000000000000000000000000000001303 158.0
HKD2_k127_1635437_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 5e-324 1004.0
HKD2_k127_1635437_1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 599.0
HKD2_k127_1635437_10 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002845 319.0
HKD2_k127_1635437_11 response regulator K02483,K07666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002789 310.0
HKD2_k127_1635437_12 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002487 315.0
HKD2_k127_1635437_13 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005301 297.0
HKD2_k127_1635437_14 MotA/TolQ/ExbB proton channel family K03561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001539 286.0
HKD2_k127_1635437_15 haloacid dehalogenase K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008129 299.0
HKD2_k127_1635437_16 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002037 265.0
HKD2_k127_1635437_17 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002771 268.0
HKD2_k127_1635437_18 Cobalamin adenosyltransferase K00798 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000006649 250.0
HKD2_k127_1635437_19 oxidation-reduction process - - - 0.0000000000000000000000000000000000000000000000000000009328 203.0
HKD2_k127_1635437_2 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003454 576.0
HKD2_k127_1635437_20 Hydrolase, P-loop family K06925 - - 0.000000000000000000000000000000000000000000005088 168.0
HKD2_k127_1635437_21 Biopolymer transport protein K03559 - - 0.00000000000000000000000000000000000000000006464 166.0
HKD2_k127_1635437_22 Aminoacyl-tRNA editing domain - - - 0.0000000000000000000000000000000000000000003958 167.0
HKD2_k127_1635437_23 Shikimate kinase K00851 - 2.7.1.12 0.00000000000000000000000000000000000000001383 158.0
HKD2_k127_1635437_24 - - - - 0.000000000000000000000002501 111.0
HKD2_k127_1635437_25 Protein of unknown function (DUF2905) - - - 0.00000000000000000000001899 102.0
HKD2_k127_1635437_26 Belongs to the UPF0434 family K09791 - - 0.00000000000000000000002182 102.0
HKD2_k127_1635437_27 Protein of Unknown function (DUF2784) - - - 0.000000000000000000007853 98.0
HKD2_k127_1635437_28 Archease protein family (MTH1598/TM1083) - - - 0.0000000000000000003432 89.0
HKD2_k127_1635437_29 sulfurtransferase K01011 - 2.8.1.1,2.8.1.2 0.000000000000000001335 85.0
HKD2_k127_1635437_3 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003333 548.0
HKD2_k127_1635437_4 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001046 490.0
HKD2_k127_1635437_5 N-Acetylmuramoyl-L-alanine amidase K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 486.0
HKD2_k127_1635437_6 His Kinase A (phosphoacceptor) domain K02484 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 418.0
HKD2_k127_1635437_7 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004659 393.0
HKD2_k127_1635437_8 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002489 364.0
HKD2_k127_1635437_9 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 340.0
HKD2_k127_1841371_0 pfam abc - - - 9.745e-242 758.0
HKD2_k127_1841371_1 D-aminoacylase domain protein K06015 - 3.5.1.81 4.174e-220 691.0
HKD2_k127_1841371_10 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000001773 159.0
HKD2_k127_1841371_11 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000002273 147.0
HKD2_k127_1841371_12 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000002625 140.0
HKD2_k127_1841371_13 - - - - 0.000000000000000000000000000002259 123.0
HKD2_k127_1841371_14 SMART Cold shock protein K03704 - - 0.00000000000000000000000000003678 117.0
HKD2_k127_1841371_15 PFAM Di-haem cytochrome c - - - 0.000000000000000000000000173 110.0
HKD2_k127_1841371_16 ubiE/COQ5 methyltransferase family - - - 0.0000000000000001468 83.0
HKD2_k127_1841371_2 PFAM ATP-binding region ATPase domain protein K07645 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004833 391.0
HKD2_k127_1841371_3 helix_turn_helix, arabinose operon control protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009413 336.0
HKD2_k127_1841371_4 PFAM response regulator receiver K02483,K07666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002871 305.0
HKD2_k127_1841371_5 NAD-dependent epimerase dehydratase K18981 - 1.1.1.203 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006976 297.0
HKD2_k127_1841371_6 Prokaryotic cytochrome b561 - - - 0.0000000000000000000000000000000000000000000000000000000000000003707 226.0
HKD2_k127_1841371_7 Protein of unknown function (DUF445) - - - 0.0000000000000000000000000000000000000000000000000000000003787 220.0
HKD2_k127_1841371_8 Putative metallopeptidase - - - 0.000000000000000000000000000000000000000000000000000000003015 210.0
HKD2_k127_1841371_9 Domain of unknown function (DUF1924) - - - 0.00000000000000000000000000000000000001257 148.0
HKD2_k127_1889530_0 UPF0313 protein - - - 0.0 1080.0
HKD2_k127_1889530_1 Periplasmic binding protein domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006229 594.0
HKD2_k127_1889530_10 ABC transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006004 254.0
HKD2_k127_1889530_11 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000002311 248.0
HKD2_k127_1889530_12 - - - - 0.000000000000000000000000000000000000000000000000000000003625 212.0
HKD2_k127_1889530_13 Cupin 2, conserved barrel - - - 0.00000000000000000000000000000000000000000000000000001197 192.0
HKD2_k127_1889530_14 Sulfurtransferase TusA - - - 0.000000000000000000000000000000000000000000000002012 179.0
HKD2_k127_1889530_15 DsrC like protein K11179 - - 0.0000000000000000000000000000000000000003688 151.0
HKD2_k127_1889530_16 Cas6 Crispr - - - 0.000000000000002927 80.0
HKD2_k127_1889530_17 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.266 0.00000001519 59.0
HKD2_k127_1889530_18 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008988,GO:0009451,GO:0009987,GO:0010467,GO:0015976,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036307,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.266 0.0001255 52.0
HKD2_k127_1889530_2 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000406 514.0
HKD2_k127_1889530_3 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 418.0
HKD2_k127_1889530_4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K03502 GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 369.0
HKD2_k127_1889530_5 response regulator K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007767 362.0
HKD2_k127_1889530_6 ATPases associated with a variety of cellular activities - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004444 326.0
HKD2_k127_1889530_7 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 323.0
HKD2_k127_1889530_8 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 317.0
HKD2_k127_1889530_9 Histidine kinase K05962 - 2.7.13.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 333.0
HKD2_k127_1898927_0 xanthine dehydrogenase activity K04108 - 1.3.7.9 6.813e-267 852.0
HKD2_k127_1898927_1 Domain present in PSD-95, Dlg, and ZO-1/2. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005841 371.0
HKD2_k127_1898927_10 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000001656 126.0
HKD2_k127_1898927_11 Cytochrome c - - - 0.000000000000000000000003713 115.0
HKD2_k127_1898927_2 PFAM Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 331.0
HKD2_k127_1898927_3 xanthine dehydrogenase activity K04109 - 1.3.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 329.0
HKD2_k127_1898927_4 4Fe-4S dicluster domain K00184 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009729 291.0
HKD2_k127_1898927_5 PFAM phospholipase A1 K01058 - 3.1.1.32,3.1.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009797 279.0
HKD2_k127_1898927_6 decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000004771 224.0
HKD2_k127_1898927_7 MarR family - - - 0.00000000000000000000000000000000000000000000000000000000016 207.0
HKD2_k127_1898927_8 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000002038 208.0
HKD2_k127_1898927_9 cytochrome c5 - - - 0.00000000000000000000000000000000000000000000000000464 194.0
HKD2_k127_1902171_0 PFAM extracellular solute-binding protein family 1 K05813 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004539 608.0
HKD2_k127_1902171_1 Amidase K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008563 587.0
HKD2_k127_1902171_2 extracellular solute-binding protein, family 5 K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009291 548.0
HKD2_k127_1902171_3 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K05816,K10111,K10112 - 3.6.3.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003646 454.0
HKD2_k127_1902171_4 PFAM binding-protein-dependent transport systems inner membrane component K05814 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002005 419.0
HKD2_k127_1902171_5 probably responsible for the translocation of the substrate across the membrane K05815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003424 415.0
HKD2_k127_1902171_6 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002376 286.0
HKD2_k127_1902171_7 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000009187 258.0
HKD2_k127_1902171_8 Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - 0.0000000000000000000000000000000000000000003428 161.0
HKD2_k127_1902171_9 SnoaL-like domain K01822 - 5.3.3.1 0.000000000000000000000000000000000000000005726 169.0
HKD2_k127_1986846_0 Protein of unknown function - - - 1.18e-313 1005.0
HKD2_k127_1986846_1 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 4.083e-295 929.0
HKD2_k127_1986846_10 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.000000000000000000000000001395 113.0
HKD2_k127_1986846_11 Zinc-finger domain - - - 0.00000000000000000000005627 102.0
HKD2_k127_1986846_12 Transcriptional regulator - - - 0.00000000000000000001059 95.0
HKD2_k127_1986846_2 modulator of DNA gyrase K03568 - - 5.255e-221 703.0
HKD2_k127_1986846_3 Phosphoglucomutase K15778 - 5.4.2.2,5.4.2.8 8.67e-206 659.0
HKD2_k127_1986846_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000527 489.0
HKD2_k127_1986846_5 alpha/beta hydrolase fold K07019 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 359.0
HKD2_k127_1986846_6 heptosyltransferase II K02843 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005111 353.0
HKD2_k127_1986846_7 COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit K01039 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005602 331.0
HKD2_k127_1986846_8 COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit K01040 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000007431 241.0
HKD2_k127_1986846_9 SnoaL-like domain - - - 0.0000000000000000000000000000000004049 148.0
HKD2_k127_2104143_0 Amidohydrolase family - - - 1.538e-223 706.0
HKD2_k127_2104143_1 Methionine synthase K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001769 556.0
HKD2_k127_2104143_2 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004873 501.0
HKD2_k127_2104143_3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K04098 - 1.13.11.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005585 348.0
HKD2_k127_2104143_4 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K12972 - 1.1.1.79,1.1.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009545 305.0
HKD2_k127_2104143_5 PFAM Phospholipase D Transphosphatidylase K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001001 283.0
HKD2_k127_2104143_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002868 268.0
HKD2_k127_2104143_7 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - 0.0000000000000000000000000000000000000000000000000000000000000007975 227.0
HKD2_k127_2104143_8 SnoaL-like domain - - - 0.0000000000000000103 97.0
HKD2_k127_213073_0 Metal-dependent amidase aminoacylase carboxypeptidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001049 483.0
HKD2_k127_213073_1 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007694 487.0
HKD2_k127_213073_10 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005122 342.0
HKD2_k127_213073_11 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000288 323.0
HKD2_k127_213073_12 PFAM Binding-protein-dependent transport system inner membrane component K02034,K15582 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 326.0
HKD2_k127_213073_13 PFAM Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008214 314.0
HKD2_k127_213073_14 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001004 286.0
HKD2_k127_213073_15 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000001999 260.0
HKD2_k127_213073_16 Putative metallopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000002205 245.0
HKD2_k127_213073_17 peptidase S16 K07157 - - 0.0000000000000000000000000000000000000000000000000000000000672 213.0
HKD2_k127_213073_18 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000000000000000000009755 174.0
HKD2_k127_213073_19 COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) K02806 - - 0.0000000000000000000000000000000000000000000008779 168.0
HKD2_k127_213073_2 Involved in the biosynthesis of porphyrin-containing compound - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008389 475.0
HKD2_k127_213073_20 COG2104 Sulfur transfer protein involved in thiamine biosynthesis K03154 - - 0.00000000000000000531 85.0
HKD2_k127_213073_3 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005563 432.0
HKD2_k127_213073_4 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 431.0
HKD2_k127_213073_5 AsmA family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 447.0
HKD2_k127_213073_6 5'-nucleotidase K01081 - 3.1.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007671 415.0
HKD2_k127_213073_7 A G-specific K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005117 409.0
HKD2_k127_213073_8 Belongs to the ABC transporter superfamily K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009484 364.0
HKD2_k127_213073_9 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 349.0
HKD2_k127_2197604_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 9.512e-261 821.0
HKD2_k127_2197604_1 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 7.687e-213 678.0
HKD2_k127_2197604_2 Mycolic acid cyclopropane synthetase K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007601 539.0
HKD2_k127_2197604_3 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 526.0
HKD2_k127_2197604_4 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000000000000000000004498 266.0
HKD2_k127_2197604_5 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.00000000000000000000000000000000000000000000000001871 185.0
HKD2_k127_2197604_6 - - - - 0.00000000000000000000005633 110.0
HKD2_k127_2197604_7 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000001505 67.0
HKD2_k127_2232881_0 PERMEase K06901 - - 1.078e-226 712.0
HKD2_k127_2232881_1 Sugar (and other) transporter K08369 - - 3.799e-222 695.0
HKD2_k127_2232881_10 [2Fe-2S] binding domain - - - 0.000000000000000000000000000000000000000000001891 180.0
HKD2_k127_2232881_11 Allophanate hydrolase K01457 - 3.5.1.54 0.00000000000000000000000000000000000000000005637 164.0
HKD2_k127_2232881_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000001591 107.0
HKD2_k127_2232881_2 Major facilitator superfamily K03446 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 575.0
HKD2_k127_2232881_3 Outer membrane efflux protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 464.0
HKD2_k127_2232881_4 PFAM secretion protein HlyD family protein K03543 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 442.0
HKD2_k127_2232881_5 Isochorismatase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000918 338.0
HKD2_k127_2232881_6 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02351 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003095 283.0
HKD2_k127_2232881_7 GntR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001538 258.0
HKD2_k127_2232881_8 SCO1/SenC K07152 - - 0.0000000000000000000000000000000000000000000000000000000000000006844 225.0
HKD2_k127_2232881_9 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000001674 211.0
HKD2_k127_2255298_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 4.816e-208 673.0
HKD2_k127_2255298_1 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002392 572.0
HKD2_k127_2255298_2 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000432 466.0
HKD2_k127_2255298_3 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 389.0
HKD2_k127_2255298_4 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006628 298.0
HKD2_k127_2255298_5 Ribosomal RNA adenine dimethylases K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002549 291.0
HKD2_k127_2255298_6 Polynucleotide kinase 3 phosphatase K03273 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0034200,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000000000000000000000000000000000001881 258.0
HKD2_k127_2255298_7 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.0000000000000000000000000000000000000000000000000000000000001607 214.0
HKD2_k127_2255298_8 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.00000000000000000000000000000000000000000000000000000175 193.0
HKD2_k127_2255298_9 Protein of unknown function DUF45 K07043 - - 0.000000000000000000000000000000000000000000000002771 184.0
HKD2_k127_2636846_0 Protein of unknown function (DUF3300) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000402 497.0
HKD2_k127_2636846_1 Predicted membrane protein (DUF2254) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 420.0
HKD2_k127_2636846_2 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 361.0
HKD2_k127_2636846_3 Sulfate transporter K17470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001225 244.0
HKD2_k127_2636846_4 Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - 0.00000000000000000000000000000000000000000000000000000004633 209.0
HKD2_k127_2636846_5 membrane - - - 0.000000000000000000000000000000000000000000000008523 192.0
HKD2_k127_2636846_6 Pfam Family of - - - 0.000000000000000000000000000000000000761 147.0
HKD2_k127_2636846_7 Na( )-dependent transporter - - - 0.00000000000000000000000000000001095 139.0
HKD2_k127_2636846_9 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0004124 52.0
HKD2_k127_267683_0 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 1.324e-318 987.0
HKD2_k127_267683_1 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 9.583e-288 896.0
HKD2_k127_267683_10 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003848 294.0
HKD2_k127_267683_11 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000008548 269.0
HKD2_k127_267683_12 Specifically methylates the N7 position of guanine in position 527 of 16S rRNA K03501 - 2.1.1.170 0.00000000000000000000000000000000000000000000000000000000000003356 223.0
HKD2_k127_267683_13 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000002267 204.0
HKD2_k127_267683_14 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109 - - 0.000000000000000000000000000000000000000000000000000129 190.0
HKD2_k127_267683_15 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.0000000000000000000000000000000000000000000000003029 183.0
HKD2_k127_267683_16 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000000000000000000000000000000000008491 171.0
HKD2_k127_267683_17 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.00000000000000000000000000000000004537 148.0
HKD2_k127_267683_18 ATP synthase I chain K02116 - - 0.00000000000000001533 93.0
HKD2_k127_267683_19 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 0.000000000001294 68.0
HKD2_k127_267683_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 2.657e-266 824.0
HKD2_k127_267683_3 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K00666,K01897 - 6.2.1.3 4.702e-220 694.0
HKD2_k127_267683_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 574.0
HKD2_k127_267683_5 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004536 497.0
HKD2_k127_267683_6 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 435.0
HKD2_k127_267683_7 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006945 424.0
HKD2_k127_267683_8 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 374.0
HKD2_k127_267683_9 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007624 335.0
HKD2_k127_2683330_0 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 5.961e-239 748.0
HKD2_k127_2683330_1 TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase K01740 - 2.5.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 537.0
HKD2_k127_2683330_2 Zinc-binding dehydrogenase K12957,K13953,K19961 - 1.1.1.1,1.1.1.258 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003555 387.0
HKD2_k127_2683330_3 Putative aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004157 333.0
HKD2_k127_2683330_4 Glutathione S-Transferase K00799 GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016740,GO:0016765,GO:0030611,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006186 272.0
HKD2_k127_2683330_5 helix_turn_helix, arabinose operon control protein - - - 0.0000000000000000000003502 101.0
HKD2_k127_2683330_7 Alpha/beta hydrolase family - - - 0.0008169 49.0
HKD2_k127_268887_0 Belongs to the peptidase M16 family K07263 - - 2.739e-255 807.0
HKD2_k127_268887_1 Amidohydrolase family - - - 8.017e-212 671.0
HKD2_k127_268887_2 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000635 460.0
HKD2_k127_268887_3 Diguanylate cyclase K21084 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000009134 224.0
HKD2_k127_268887_4 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide K01574 - 4.1.1.4 0.00000000000000002978 91.0
HKD2_k127_2702666_0 Dehydrogenase K00382 - 1.8.1.4 1.022e-268 838.0
HKD2_k127_2702666_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00382,K00627 - 1.8.1.4,2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006197 517.0
HKD2_k127_2702666_2 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 479.0
HKD2_k127_2702666_3 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005127 339.0
HKD2_k127_2702666_4 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001242 301.0
HKD2_k127_2702666_5 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000002665 217.0
HKD2_k127_2702666_6 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.000000000000000000000000000000000000000007681 166.0
HKD2_k127_2702666_7 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000004727 98.0
HKD2_k127_2703597_0 May be involved in recombinational repair of damaged DNA K03631 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007935 512.0
HKD2_k127_2703597_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 473.0
HKD2_k127_2703597_2 Ferrochelatase K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000325 403.0
HKD2_k127_2703597_3 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004833 344.0
HKD2_k127_2703597_4 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004598 314.0
HKD2_k127_2703597_5 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000000000002925 214.0
HKD2_k127_2703597_6 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.000000000000000000000004073 108.0
HKD2_k127_2741376_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001604 574.0
HKD2_k127_2741376_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009221 480.0
HKD2_k127_2741376_2 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000935 285.0
HKD2_k127_2741376_3 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.00000000000000000000000000000000000000000008457 162.0
HKD2_k127_2741376_6 - - - - 0.0000003388 51.0
HKD2_k127_2741524_0 UDP binding domain K00012 - 1.1.1.22 3.274e-197 628.0
HKD2_k127_2741524_1 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.7.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000048 612.0
HKD2_k127_2741524_2 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008319 541.0
HKD2_k127_2741524_3 Belongs to the cysteine synthase cystathionine beta- synthase family K12339 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005133 496.0
HKD2_k127_2741524_4 Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose K03274 - 5.1.3.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 458.0
HKD2_k127_2741524_5 pfkB family carbohydrate kinase K21344 - 2.7.1.167 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005151 405.0
HKD2_k127_2741524_6 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB K07501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003609 382.0
HKD2_k127_2741524_7 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003389 327.0
HKD2_k127_2741524_8 Inhibitor of apoptosis-promoting Bax1 K19416 - - 0.00000000000000000000000000000000000000000000000000000000000000002112 232.0
HKD2_k127_2741524_9 Specifically methylates the adenine in position 2030 of 23S rRNA K07115 - 2.1.1.266 0.0000000000000000005488 89.0
HKD2_k127_276947_0 Class II Aldolase and Adducin N-terminal domain - - - 2.029e-271 852.0
HKD2_k127_276947_1 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 549.0
HKD2_k127_276947_10 Belongs to the GcvT family K06980 - - 0.00000000000000000000000000000000000000000000000000000000000000000005227 242.0
HKD2_k127_276947_11 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000000000000002152 226.0
HKD2_k127_276947_12 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K11991 - 3.5.4.33 0.0000000000000000000000000000000000000000001551 172.0
HKD2_k127_276947_13 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.000000000000000000000000000000000000000001616 156.0
HKD2_k127_276947_14 ankyrin repeat K06867 - - 0.00000000000000000000000000000000000005808 158.0
HKD2_k127_276947_15 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000002347 151.0
HKD2_k127_276947_16 SecretomeP prediction - - - 0.00000000000000000000000000000002534 134.0
HKD2_k127_276947_17 Domain of unknown function (DUF4936) - - - 0.00000000001429 76.0
HKD2_k127_276947_2 COG2309 Leucyl aminopeptidase (aminopeptidase T) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005285 496.0
HKD2_k127_276947_3 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 419.0
HKD2_k127_276947_4 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 385.0
HKD2_k127_276947_5 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000933 334.0
HKD2_k127_276947_6 Transport and Golgi organisation 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001317 258.0
HKD2_k127_276947_7 ErfK YbiS YcfS YnhG family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004699 255.0
HKD2_k127_276947_8 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001991 251.0
HKD2_k127_276947_9 dna polymerase iii K02341 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000001059 248.0
HKD2_k127_2790508_0 PFAM AMP-dependent synthetase and ligase K00666 - - 4.267e-305 977.0
HKD2_k127_2790508_1 AAA domain - - - 3.909e-286 901.0
HKD2_k127_2790508_10 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000006808 250.0
HKD2_k127_2790508_11 thiolester hydrolase activity K07100 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000004637 230.0
HKD2_k127_2790508_12 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000001637 160.0
HKD2_k127_2790508_13 PFAM UspA - - - 0.000000000000000000000008579 112.0
HKD2_k127_2790508_2 ABC transporter transmembrane region K06147 - - 3.402e-243 764.0
HKD2_k127_2790508_3 4Fe-4S ferredoxin, iron-sulfur binding K18929 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003731 592.0
HKD2_k127_2790508_4 COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase K01652 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007675 471.0
HKD2_k127_2790508_5 Cysteine-rich domain K18928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005435 363.0
HKD2_k127_2790508_6 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000622 323.0
HKD2_k127_2790508_7 Methyl-transferase K18911 - 2.1.1.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006896 321.0
HKD2_k127_2790508_8 Beta-lactamase enzyme family K07262 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 301.0
HKD2_k127_2790508_9 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004501 244.0
HKD2_k127_2817667_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 7.863e-197 622.0
HKD2_k127_2817667_1 Protein of unknown function (DUF1116) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003635 573.0
HKD2_k127_2817667_2 Allophanate hydrolase K01457 - 3.5.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 562.0
HKD2_k127_2817667_3 CoA-ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 479.0
HKD2_k127_2817667_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 468.0
HKD2_k127_2817667_5 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006828 470.0
HKD2_k127_2817667_6 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 370.0
HKD2_k127_2817667_7 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.00000000000000000000000000000000000000000000000000000001623 206.0
HKD2_k127_2817667_8 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000003924 168.0
HKD2_k127_2817667_9 - - - - 0.0000000000000000000000000000000006561 141.0
HKD2_k127_2828935_0 TRAP transporter, 4TM 12TM fusion protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004369 612.0
HKD2_k127_2828935_1 TRAP transporter, solute receptor (TAXI family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009951 334.0
HKD2_k127_2828935_2 alpha-ribazole phosphatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000008128 241.0
HKD2_k127_2828935_3 Bacterial extracellular solute-binding protein K02020 - - 0.00000000000000000000000000000000000000000000000000000000000002177 223.0
HKD2_k127_2828935_4 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.0000001465 53.0
HKD2_k127_2852808_0 Belongs to the IlvD Edd family K01687,K22186 - 4.2.1.82,4.2.1.9 4.985e-267 853.0
HKD2_k127_2852808_1 transport system fused permease components - - - 2.989e-224 716.0
HKD2_k127_2852808_10 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002913 368.0
HKD2_k127_2852808_11 NMT1-like family K07080 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 360.0
HKD2_k127_2852808_12 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain K07711 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001929 362.0
HKD2_k127_2852808_13 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K22229 - 1.1.1.215 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 333.0
HKD2_k127_2852808_14 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 309.0
HKD2_k127_2852808_15 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000163 268.0
HKD2_k127_2852808_16 2-Keto-4-pentenoate hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000002659 240.0
HKD2_k127_2852808_17 Protein of unknown function (DUF1223) - - - 0.000000000000000000000000000000000000000000000000000002176 200.0
HKD2_k127_2852808_18 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.00000000000000000000000000000000000000000000009974 187.0
HKD2_k127_2852808_19 Belongs to the MraZ family K03925 - - 0.000000000000000000000000000000000000000000001735 170.0
HKD2_k127_2852808_2 Metallopeptidase family M24 - - - 1.302e-209 661.0
HKD2_k127_2852808_20 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.0000000000000000000005678 98.0
HKD2_k127_2852808_21 (ABC) transporter - - - 0.000003205 56.0
HKD2_k127_2852808_22 DNA-sulfur modification-associated - - - 0.000004041 59.0
HKD2_k127_2852808_23 - - - - 0.00008729 50.0
HKD2_k127_2852808_3 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 1.515e-207 668.0
HKD2_k127_2852808_4 two component, sigma54 specific, transcriptional regulator, Fis family K07714,K07715 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007437 556.0
HKD2_k127_2852808_5 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 538.0
HKD2_k127_2852808_6 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002131 494.0
HKD2_k127_2852808_7 TIGRFAM 3-oxoacid CoA-transferase, B subunit K01032 - 2.8.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004901 461.0
HKD2_k127_2852808_8 Malate/L-lactate dehydrogenase K16844 - 1.1.1.338 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001557 429.0
HKD2_k127_2852808_9 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 378.0
HKD2_k127_2868771_0 acyl-CoA dehydrogenase activity K09456 - - 2.079e-198 634.0
HKD2_k127_2868771_1 Belongs to the short-chain dehydrogenases reductases (SDR) family K00023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.1.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008361 444.0
HKD2_k127_2868771_2 Belongs to the MenA family. Type 1 subfamily K02548 GO:0003674,GO:0003824,GO:0004659,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 390.0
HKD2_k127_2868771_3 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004666 375.0
HKD2_k127_2868771_4 Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds K10026 - 4.3.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 304.0
HKD2_k127_2868771_5 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000015 175.0
HKD2_k127_2868771_6 methyltransferase activity K21310 - 2.1.1.334 0.0000000000000000000000000000000000000000002336 160.0
HKD2_k127_2868771_7 PFAM 6-pyruvoyl tetrahydropterin synthase K01737 - 4.1.2.50,4.2.3.12 0.000000000000000000000000000003371 123.0
HKD2_k127_2868771_8 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000000001582 93.0
HKD2_k127_2868771_9 - - - - 0.00000000000006352 76.0
HKD2_k127_293359_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 1.74e-317 985.0
HKD2_k127_293359_1 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 6.765e-265 839.0
HKD2_k127_293359_10 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000002888 149.0
HKD2_k127_293359_2 Exopolyphosphatase K01524 - 3.6.1.11,3.6.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 549.0
HKD2_k127_293359_3 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005458 516.0
HKD2_k127_293359_4 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001745 452.0
HKD2_k127_293359_5 Belongs to the MtfA family K09933 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001275 270.0
HKD2_k127_293359_6 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001625 266.0
HKD2_k127_293359_7 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000045 250.0
HKD2_k127_293359_8 phosphohistidine phosphatase, SixA K08296 - - 0.00000000000000000000000000000000000000000000000001539 184.0
HKD2_k127_293359_9 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.00000000000000000000000000000000000000000003893 163.0
HKD2_k127_3025218_0 AMP-binding enzyme C-terminal domain K00666 - - 1.264e-212 682.0
HKD2_k127_3025218_1 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004 602.0
HKD2_k127_3025218_10 Permeases of the major facilitator superfamily - - - 0.000000000000000000000001429 109.0
HKD2_k127_3025218_11 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.00000000004196 75.0
HKD2_k127_3025218_12 hyperosmotic response K04065 - - 0.00007066 54.0
HKD2_k127_3025218_13 - - - - 0.0001659 47.0
HKD2_k127_3025218_2 COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 491.0
HKD2_k127_3025218_3 Belongs to the UPF0271 (lamB) family K07160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008951 321.0
HKD2_k127_3025218_4 Allophanate hydrolase subunit 2 K06350 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000006969 280.0
HKD2_k127_3025218_5 Nitrile hydratase K01721,K20807 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000381 265.0
HKD2_k127_3025218_6 Eukaryotic integral membrane protein (DUF1751) - - - 0.0000000000000000000000000000000000000000000000000000000000003179 214.0
HKD2_k127_3025218_7 Glyoxalase-like domain - - - 0.000000000000000000000000000000000000000000000000003089 198.0
HKD2_k127_3025218_8 Allophanate hydrolase subunit 1 - - - 0.00000000000000000000000000000000000000000000000001222 192.0
HKD2_k127_3025218_9 Nitrile hydratase beta subunit K20807 - 4.2.1.84 0.000000000000000000000000000000000000000196 152.0
HKD2_k127_3104214_0 3-hydroxyacyl-CoA dehydrogenase K01782 - 1.1.1.35,4.2.1.17,5.1.2.3 3.197e-234 741.0
HKD2_k127_3104214_1 Belongs to the thiolase family K00626 - 2.3.1.9 1.605e-201 640.0
HKD2_k127_3104214_2 acyl-CoA dehydrogenase K06445 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008577 516.0
HKD2_k127_3104214_3 Alpha/beta hydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000001723 234.0
HKD2_k127_3104214_4 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000003279 218.0
HKD2_k127_3104214_5 Thioesterase superfamily K10806 - - 0.00000000000000000000000000000000000000000000000002531 181.0
HKD2_k127_3130033_0 Amidohydrolase K10220 - 4.2.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 604.0
HKD2_k127_3130033_1 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001939 404.0
HKD2_k127_3130033_10 ABC transporter substrate-binding protein - - - 0.00000000000000000000000000000000000012 155.0
HKD2_k127_3130033_11 lactoylglutathione lyase activity - - - 0.0000000000000000000000000001894 115.0
HKD2_k127_3130033_12 Tripartite tricarboxylate transporter TctB family - - - 0.00003848 52.0
HKD2_k127_3130033_2 Catalyzes the conversion of acetoacetate to acetone and carbon dioxide K01574 - 4.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006934 404.0
HKD2_k127_3130033_3 Psort location CytoplasmicMembrane, score 10.00 K07793 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005017 361.0
HKD2_k127_3130033_4 Belongs to the short-chain dehydrogenases reductases (SDR) family K00019 - 1.1.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004713 347.0
HKD2_k127_3130033_5 PFAM Dimethylmenaquinone methyltransferase K02553,K10218 - 4.1.3.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003308 298.0
HKD2_k127_3130033_6 Esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003504 291.0
HKD2_k127_3130033_7 4,5-dihydroxyphthalate decarboxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003814 273.0
HKD2_k127_3130033_8 Domain of unknown function (DUF1932) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003283 257.0
HKD2_k127_3130033_9 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000009235 250.0
HKD2_k127_3198993_0 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position K00700 - 2.4.1.18 3.787e-320 989.0
HKD2_k127_3198993_1 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 2.167e-290 910.0
HKD2_k127_3198993_2 Belongs to the HypD family K04654 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006747 557.0
HKD2_k127_3198993_3 Hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002682 335.0
HKD2_k127_3198993_4 Ni,Fe-hydrogenase I large subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002828 255.0
HKD2_k127_3198993_5 Belongs to the bacterial glucokinase family K00845 - 2.7.1.2 0.00000000000000000000000000000000000000000000001329 196.0
HKD2_k127_3198993_6 Hydrogenase/urease nickel incorporation, metallochaperone, hypA K04651 - - 0.0000000000000000000000000003161 120.0
HKD2_k127_3198993_7 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.00000000000000000000000001813 111.0
HKD2_k127_3198993_8 HupF/HypC family K04653 - - 0.00000000000000000000001213 103.0
HKD2_k127_3198993_9 Histidine kinase-like ATPase domain - - - 0.0000000000000000000009745 107.0
HKD2_k127_3208092_0 Belongs to the ABC transporter superfamily K02031,K02032 - - 1.293e-260 822.0
HKD2_k127_3208092_1 COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 503.0
HKD2_k127_3208092_10 PFAM Bacterial extracellular solute-binding - - - 0.00000000006874 63.0
HKD2_k127_3208092_2 PFAM binding-protein-dependent transport systems inner membrane component K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 511.0
HKD2_k127_3208092_3 COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) K08307 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 422.0
HKD2_k127_3208092_4 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004003 345.0
HKD2_k127_3208092_5 Haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002491 301.0
HKD2_k127_3208092_6 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000131 287.0
HKD2_k127_3208092_7 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002549 267.0
HKD2_k127_3208092_8 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000001163 234.0
HKD2_k127_3226256_0 alpha-glucan phosphorylase K00688 - 2.4.1.1 0.0 1057.0
HKD2_k127_3226256_1 TRAP dicarboxylate transporter, DctM subunit K11690 - - 4.531e-222 696.0
HKD2_k127_3226256_2 Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc K00975 - 2.7.7.27 1.582e-194 617.0
HKD2_k127_3226256_3 C4-dicarboxylate ABC transporter K11688 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 504.0
HKD2_k127_3226256_4 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 416.0
HKD2_k127_3226256_5 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007075 312.0
HKD2_k127_3226256_6 Tripartite ATP-independent periplasmic transporters, DctQ component K11689 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000359 294.0
HKD2_k127_3254108_0 Putative diguanylate phosphodiesterase - - - 1.011e-258 835.0
HKD2_k127_3254108_1 Cys/Met metabolism PLP-dependent enzyme K01740 - 2.5.1.49 1.484e-213 670.0
HKD2_k127_3254108_10 ATPases associated with a variety of cellular activities K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000405 355.0
HKD2_k127_3254108_11 ATPases associated with a variety of cellular activities K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 354.0
HKD2_k127_3254108_12 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004423 302.0
HKD2_k127_3254108_13 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 297.0
HKD2_k127_3254108_14 oxidation-reduction process - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008741 293.0
HKD2_k127_3254108_15 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 291.0
HKD2_k127_3254108_16 PFAM oxidoreductase FAD NAD(P)-binding domain protein K00528 - 1.18.1.2,1.19.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004233 290.0
HKD2_k127_3254108_17 Alpha beta hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009415 273.0
HKD2_k127_3254108_18 Alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000000000000000008325 239.0
HKD2_k127_3254108_19 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186,K16875 - 2.5.1.129 0.0000000000000000000000000000000000000000000000000000000000000000005973 243.0
HKD2_k127_3254108_2 Receptor family ligand binding region K01999 - - 8.947e-201 636.0
HKD2_k127_3254108_20 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000002595 215.0
HKD2_k127_3254108_21 - - - - 0.00000000000000000000000000000000000000009587 157.0
HKD2_k127_3254108_22 Cysteine dioxygenase type I - - - 0.0000000000000000000000000000001366 141.0
HKD2_k127_3254108_23 MarR family - - - 0.00000000000000000000000000002564 123.0
HKD2_k127_3254108_24 Domain of unknown function (DUF1992) - - - 0.00000000000000000000000003724 111.0
HKD2_k127_3254108_25 - - - - 0.00000000000000000000002749 112.0
HKD2_k127_3254108_26 Belongs to the GMC oxidoreductase family - - - 0.00000000000000000000005004 100.0
HKD2_k127_3254108_27 Protein of unknown function (DUF3301) - - - 0.000000000000000001089 98.0
HKD2_k127_3254108_29 type I phosphodiesterase nucleotide pyrophosphatase - - - 0.00000000003684 66.0
HKD2_k127_3254108_3 Belongs to the GMC oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008565 576.0
HKD2_k127_3254108_30 Protein of unknown function (DUF3567) - - - 0.0000000001766 65.0
HKD2_k127_3254108_4 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001932 546.0
HKD2_k127_3254108_5 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 531.0
HKD2_k127_3254108_6 FAD dependent oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008428 485.0
HKD2_k127_3254108_7 Branched-chain amino acid transport system / permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005444 431.0
HKD2_k127_3254108_8 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002572 424.0
HKD2_k127_3254108_9 PFAM multi antimicrobial extrusion protein MatE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003714 389.0
HKD2_k127_3288947_0 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004257 392.0
HKD2_k127_3288947_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005378 299.0
HKD2_k127_3288947_2 auxin efflux carrier K07088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008177 281.0
HKD2_k127_3288947_3 helix_turn_helix, Lux Regulon - - - 0.000000000000000000000000000000000000000000000000000006082 193.0
HKD2_k127_3288947_4 PFAM Sel1 domain protein repeat-containing protein K07126 - - 0.00005887 53.0
HKD2_k127_3288947_5 Sel1 domain protein repeat-containing protein K07126 - - 0.00008184 52.0
HKD2_k127_3334674_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 566.0
HKD2_k127_3334674_1 Uncharacterised ArCR, COG2043 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004544 417.0
HKD2_k127_3334674_10 - - - - 0.000000000000000000000006865 105.0
HKD2_k127_3334674_2 Zinc-binding dehydrogenase K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004285 407.0
HKD2_k127_3334674_3 MASE2 domain K18968 - 2.7.7.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003665 341.0
HKD2_k127_3334674_4 Enoyl-CoA hydratase carnithine racemase K01692,K11264 - 4.1.1.41,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 304.0
HKD2_k127_3334674_5 Aminotransferase class I and II K11358 - 2.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000005158 227.0
HKD2_k127_3334674_6 - - - - 0.00000000000000000000000000000000000000000000000000000000002823 213.0
HKD2_k127_3334674_7 MAPEG family - - - 0.0000000000000000000000000000000000000000003533 162.0
HKD2_k127_3334674_8 Glycine-zipper domain - - - 0.0000000000000000000000000000000000000001167 160.0
HKD2_k127_3334674_9 pyridoxamine 5-phosphate - - - 0.0000000000000000000000000000004201 130.0
HKD2_k127_3373928_0 PFAM AMP-dependent synthetase and ligase K12508 - 6.2.1.34 9.924e-214 680.0
HKD2_k127_3373928_1 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000187 576.0
HKD2_k127_3373928_2 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 336.0
HKD2_k127_3373928_3 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 355.0
HKD2_k127_3373928_4 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000005278 231.0
HKD2_k127_3373928_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000000000006548 122.0
HKD2_k127_3373928_6 Thioredoxin K05838 - - 0.000000000000000001563 89.0
HKD2_k127_3382692_0 Fumarate reductase flavoprotein C-term K00239,K00244 - 1.3.5.1,1.3.5.4 3.837e-278 874.0
HKD2_k127_3382692_1 D-galactarate dehydratase / Altronate hydrolase, C terminus K16846 - 4.4.1.24 2.708e-216 675.0
HKD2_k127_3382692_10 Belongs to the LDH2 MDH2 oxidoreductase family K16844 - 1.1.1.338 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 375.0
HKD2_k127_3382692_11 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003283 372.0
HKD2_k127_3382692_12 TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001519 376.0
HKD2_k127_3382692_13 Gliding motility protein GldG - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 362.0
HKD2_k127_3382692_14 Fumarase C-terminus K01678,K03780 - 4.2.1.2,4.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007014 320.0
HKD2_k127_3382692_15 Belongs to the SUA5 family K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 333.0
HKD2_k127_3382692_16 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003186 297.0
HKD2_k127_3382692_17 dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001671 277.0
HKD2_k127_3382692_18 UTRA K03710 - - 0.00000000000000000000000000000000000000000000000000000000000000000003163 239.0
HKD2_k127_3382692_19 Universal stress protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000005986 237.0
HKD2_k127_3382692_2 PhoD-like phosphatase, N-terminal domain K01113 - 3.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003242 499.0
HKD2_k127_3382692_20 Belongs to the TPP enzyme family - - - 0.00000000000000000000000000000000000000000000000000000000000000001875 240.0
HKD2_k127_3382692_21 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000001389 201.0
HKD2_k127_3382692_22 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - - 0.000000000000000000000000000000000000000000000000718 195.0
HKD2_k127_3382692_23 Chalcone isomerase-like - - - 0.0000000000000000000000000000000000000000000002484 174.0
HKD2_k127_3382692_24 SAF K16845 - 4.4.1.24 0.00000000000000000000000000000000000000001592 154.0
HKD2_k127_3382692_25 succinate dehydrogenase K00247 - - 0.000000000000000000000000000000000000003409 154.0
HKD2_k127_3382692_26 succinate dehydrogenase K00246 - - 0.00000000000000000000003183 112.0
HKD2_k127_3382692_27 Domain of unknown function (DUF4340) - - - 0.00000000000000001268 96.0
HKD2_k127_3382692_28 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.000703 51.0
HKD2_k127_3382692_3 Fumarate hydratase (Fumerase) K01677,K03779 - 4.2.1.2,4.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003465 459.0
HKD2_k127_3382692_4 ABC-type nitrate sulfonate bicarbonate transport system, periplasmic component K02051 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 439.0
HKD2_k127_3382692_5 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000324 431.0
HKD2_k127_3382692_6 phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001111 446.0
HKD2_k127_3382692_7 Fructose-bisphosphate aldolase class-I K01623 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 425.0
HKD2_k127_3382692_8 ABC-type nitrate sulfonate bicarbonate transport system ATPase component K02049 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005479 402.0
HKD2_k127_3382692_9 Tyrosine recombinase XerD K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001928 378.0
HKD2_k127_3419952_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005387 375.0
HKD2_k127_3419952_1 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008101 357.0
HKD2_k127_3419952_2 MgtC family K07507 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003558 286.0
HKD2_k127_3419952_3 NMT1-like family K07080 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004818 275.0
HKD2_k127_3419952_4 lactoylglutathione lyase activity - - - 0.000000000000000000000000000000000000000000000000000000000000001786 221.0
HKD2_k127_3419952_5 transposase activity K07483,K07497 - - 0.000000000000000000008414 95.0
HKD2_k127_3419952_6 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000000002249 88.0
HKD2_k127_3419952_7 - - - - 0.000007611 51.0
HKD2_k127_3419952_8 Gram-negative porin - - - 0.0001242 44.0
HKD2_k127_342913_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895,K01907 - 6.2.1.1,6.2.1.16 7.578e-266 837.0
HKD2_k127_342913_1 Thiamine pyrophosphate enzyme, central domain K01652 - 2.2.1.6 9.164e-227 715.0
HKD2_k127_342913_10 NIPSNAP - - - 0.00000000000000000000000000000000000000000000000007268 179.0
HKD2_k127_342913_11 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000002095 169.0
HKD2_k127_342913_12 Phospholipase/Carboxylesterase K06999 - - 0.0000000000000000000000000000000000000687 156.0
HKD2_k127_342913_13 Putative zinc- or iron-chelating domain K06940 - - 0.0000000000000000000000000000000000001076 146.0
HKD2_k127_342913_14 helix-turn-helix- domain containing protein AraC type - - - 0.0000000000000001664 87.0
HKD2_k127_342913_15 - - - - 0.0003933 50.0
HKD2_k127_342913_2 PFAM ABC transporter K02471 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 570.0
HKD2_k127_342913_3 ABC transporter K10004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004131 400.0
HKD2_k127_342913_4 Bacterial periplasmic substrate-binding proteins K02030,K10001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001391 377.0
HKD2_k127_342913_5 TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family K02029,K10003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008903 345.0
HKD2_k127_342913_6 TIGRFAM amine acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine family K10002 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 343.0
HKD2_k127_342913_7 Carboxylesterase family K01066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004926 335.0
HKD2_k127_342913_8 CoA-binding protein K06929 - - 0.00000000000000000000000000000000000000000000000000000000000000000003278 235.0
HKD2_k127_342913_9 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.00000000000000000000000000000000000000000000000000000005001 209.0
HKD2_k127_3522803_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K11747 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003567 543.0
HKD2_k127_3522803_1 Flavodoxin-like fold K03923,K11748 - - 0.0000000000000000000000000000000000000000000000000000002597 199.0
HKD2_k127_3522803_2 Flavin reductase like domain - - - 0.000000000000000000000000000000000000000000009181 174.0
HKD2_k127_3522803_3 Flavin reductase like domain K13786 - 1.16.8.1 0.000000000000000000000000000000000001057 145.0
HKD2_k127_3522803_4 Antibiotic biosynthesis monooxygenase - - - 0.000000000000009225 78.0
HKD2_k127_3541710_0 Transmembrane secretion effector - - - 6.34e-224 710.0
HKD2_k127_3541710_1 Sulfatase - - - 2.322e-194 614.0
HKD2_k127_3541710_10 N-terminal half of MaoC dehydratase - - - 0.0000000000000000000000000000000000000000000000009467 180.0
HKD2_k127_3541710_11 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000006338 177.0
HKD2_k127_3541710_12 - - - - 0.0000000000000000000000000000000000001914 149.0
HKD2_k127_3541710_13 HNH nucleases - - - 0.00000000000000000000000000000003001 145.0
HKD2_k127_3541710_14 CoA binding domain K09181 - - 0.0000000000000000005079 93.0
HKD2_k127_3541710_15 - - - - 0.00000000000000004746 84.0
HKD2_k127_3541710_17 Acyl CoA binding protein - - - 0.00003106 56.0
HKD2_k127_3541710_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000436 617.0
HKD2_k127_3541710_3 PFAM L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003271 516.0
HKD2_k127_3541710_4 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003019 508.0
HKD2_k127_3541710_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000213 438.0
HKD2_k127_3541710_6 dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 344.0
HKD2_k127_3541710_7 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001176 307.0
HKD2_k127_3541710_8 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002688 278.0
HKD2_k127_3541710_9 - - - - 0.000000000000000000000000000000000000000000000000000003137 196.0
HKD2_k127_3673384_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 2.707e-288 906.0
HKD2_k127_3673384_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 526.0
HKD2_k127_3673384_10 Fe-S assembly protein IscX - - - 0.0000000000000000000000008588 111.0
HKD2_k127_3673384_11 Belongs to the BolA IbaG family K05527,K22066 GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564 - 0.000000000000000008547 98.0
HKD2_k127_3673384_12 Domain of unknown function (DUF4124) - - - 0.0008363 50.0
HKD2_k127_3673384_2 probably involved in intracellular septation K06190 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001637 248.0
HKD2_k127_3673384_3 peptidylprolyl isomerase K03769 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000003051 250.0
HKD2_k127_3673384_4 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004159 239.0
HKD2_k127_3673384_5 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000003567 239.0
HKD2_k127_3673384_6 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000000000000000000000000000000001024 190.0
HKD2_k127_3673384_7 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 - - 0.00000000000000000000000000000000000000000000000002768 187.0
HKD2_k127_3673384_8 2Fe-2S iron-sulfur cluster binding domain K04755 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840 - 0.00000000000000000000000000000000000000000000000003195 180.0
HKD2_k127_3673384_9 PFAM Appr-1-p processing domain protein - - - 0.00000000000000000000000000000004579 136.0
HKD2_k127_3835821_0 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006742 551.0
HKD2_k127_3835821_1 Cache domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001036 288.0
HKD2_k127_3835821_2 luxR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001471 258.0
HKD2_k127_3835821_3 Histidine kinase K07675 - 2.7.13.3 0.000000000000000000000000000000000000000000000000001498 204.0
HKD2_k127_3835821_4 endoribonuclease L-PSP - - - 0.00000000000000000000000000000000000000000000009404 180.0
HKD2_k127_3835821_5 TPR repeat - - - 0.000000000000000000000000000000005545 130.0
HKD2_k127_3835821_6 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.0003084 50.0
HKD2_k127_3880633_0 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 6.256e-222 706.0
HKD2_k127_3880633_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 2.658e-195 620.0
HKD2_k127_3880633_10 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000004221 147.0
HKD2_k127_3880633_11 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000005311 87.0
HKD2_k127_3880633_12 Transmembrane anti-sigma factor - - - 0.00000000005155 66.0
HKD2_k127_3880633_2 Cobalamin synthesis protein cobW C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002175 464.0
HKD2_k127_3880633_3 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008564 457.0
HKD2_k127_3880633_4 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005382 374.0
HKD2_k127_3880633_5 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007773 373.0
HKD2_k127_3880633_6 acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004684 287.0
HKD2_k127_3880633_7 Protein of unknown function, DUF484 K09921 - - 0.00000000000000000000000000000000000000000000000000000000000000363 235.0
HKD2_k127_3880633_8 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000003749 198.0
HKD2_k127_3880633_9 coa-binding K06929 - - 0.0000000000000000000000000000000000000000000001614 173.0
HKD2_k127_3896116_0 Vitamin B12 dependent methionine synthase activation region K00548 - 2.1.1.13 0.0 1692.0
HKD2_k127_3896116_1 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - 4.588e-227 726.0
HKD2_k127_3896116_10 Small membrane protein - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000006745 139.0
HKD2_k127_3896116_11 Thioesterase superfamily - - - 0.00000000000000000000000008366 111.0
HKD2_k127_3896116_2 TrkA-N domain protein K03499 - - 1.69e-197 625.0
HKD2_k127_3896116_3 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 600.0
HKD2_k127_3896116_4 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003426 419.0
HKD2_k127_3896116_5 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001367 412.0
HKD2_k127_3896116_6 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000375 338.0
HKD2_k127_3896116_7 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.000000000000000000000000000000000000000000000000000000000000000005352 229.0
HKD2_k127_3896116_8 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000000000000007944 223.0
HKD2_k127_3896116_9 signal peptide protein - - - 0.0000000000000000000000000000000000000000000002072 176.0
HKD2_k127_4027785_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 6.94e-201 637.0
HKD2_k127_4027785_1 Possible lysine decarboxylase K06966 - 3.2.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005449 370.0
HKD2_k127_4027785_2 Putative beta-barrel porin 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000004316 240.0
HKD2_k127_4027785_3 ribosomal large subunit export from nucleus - - - 0.000000000000000000000000000000000000000000000000000007201 192.0
HKD2_k127_4027785_4 Universal stress protein - - - 0.00000000000000000000000000000000000002711 148.0
HKD2_k127_4027785_5 THUMP - - - 0.00000000000000000007646 100.0
HKD2_k127_4027785_6 - - - - 0.0000000000000000003696 92.0
HKD2_k127_4028054_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 535.0
HKD2_k127_4028054_1 serine threonine protein kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005659 391.0
HKD2_k127_4028054_2 Stress-induced protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006026 284.0
HKD2_k127_4028054_3 COG0631 Serine threonine protein phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000005658 267.0
HKD2_k127_4028054_4 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000000000000000000000000000000003982 237.0
HKD2_k127_4028054_5 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000000000000002484 109.0
HKD2_k127_4042241_0 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003118 563.0
HKD2_k127_4042241_1 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003024 469.0
HKD2_k127_4042241_2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 319.0
HKD2_k127_4042241_3 TolA binding protein trimerisation - - - 0.000000000000000000000000000000000000000000000000000005057 199.0
HKD2_k127_4042241_4 Belongs to the ompA family K03640 - - 0.00000000000000000000000000000000000000000000007615 189.0
HKD2_k127_4042241_5 Dopa 4,5-dioxygenase family K10253 - - 0.0000000000000000724 85.0
HKD2_k127_4042852_0 Ammonium Transporter K03320 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 524.0
HKD2_k127_4042852_1 AMP-binding enzyme C-terminal domain K04110,K20458 - 6.2.1.25,6.2.1.27,6.2.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004365 345.0
HKD2_k127_4042852_2 AMP-binding enzyme C-terminal domain K04110,K20458 - 6.2.1.25,6.2.1.27,6.2.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007328 344.0
HKD2_k127_4042852_3 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 293.0
HKD2_k127_4042852_4 COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) K16165 - 3.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000715 281.0
HKD2_k127_4042852_5 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003556 280.0
HKD2_k127_4042852_6 maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000305 281.0
HKD2_k127_4176828_0 Aminotransferase class-V K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 3.875e-197 626.0
HKD2_k127_4176828_1 Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system K14058 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 436.0
HKD2_k127_4176828_2 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004764 413.0
HKD2_k127_4176828_3 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002158 280.0
HKD2_k127_4176828_4 KR domain K00059,K18337 - 1.1.1.100,1.1.1.173,1.1.1.377,1.1.1.378 0.0000000000000000000000000000000000000000000000000000000000000000000000000003389 269.0
HKD2_k127_4176828_5 MltA-interacting protein MipA - - - 0.000000000000000000000000000000000000000000000000000000000000000000002464 246.0
HKD2_k127_4176828_6 Alpha beta hydrolase K00433 - 1.11.1.10 0.00000000000000000000005998 102.0
HKD2_k127_4176828_7 serine threonine protein kinase K08282 - 2.7.11.1 0.000000000000001426 78.0
HKD2_k127_4176828_8 -Thioesterase K01075 - 3.1.2.23 0.000000001066 67.0
HKD2_k127_4226421_0 glutamate synthase K00265 - 1.4.1.13,1.4.1.14 0.0 1621.0
HKD2_k127_4226421_1 glutamate synthase K00266 - 1.4.1.13,1.4.1.14 6.705e-244 760.0
HKD2_k127_4226421_2 Aminotransferase class-III K00821 GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006564 477.0
HKD2_k127_4226421_3 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004906 342.0
HKD2_k127_4245425_0 Long-chain acyl-CoA synthetases (AMP-forming) K01897 - 6.2.1.3 6.034e-291 905.0
HKD2_k127_4245425_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 5.604e-203 642.0
HKD2_k127_4245425_10 2-hydroxychromene-2-carboxylate isomerase K14584 - 5.99.1.4 0.0000000000000000000000000000000000000000000000000000001979 198.0
HKD2_k127_4245425_11 PFAM extracellular solute-binding protein family 3 K02030,K09969,K10001 - - 0.00000000000000000000000000000000000000000000000000000238 201.0
HKD2_k127_4245425_12 Secreted repeat of unknown function - - - 0.00000000000000000000000000000000000001071 149.0
HKD2_k127_4245425_13 Mo-co oxidoreductase dimerisation domain - - - 0.00000000000000000000000001075 113.0
HKD2_k127_4245425_2 - - - - 5.506e-202 646.0
HKD2_k127_4245425_3 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 534.0
HKD2_k127_4245425_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 528.0
HKD2_k127_4245425_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001198 509.0
HKD2_k127_4245425_6 branched-chain amino acid K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004901 445.0
HKD2_k127_4245425_7 Branched-chain amino acid ATP-binding cassette transporter K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002984 411.0
HKD2_k127_4245425_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002986 411.0
HKD2_k127_4245425_9 von Willebrand factor (vWF) type A domain - - - 0.000000000000000000000000000000000000000000000000000000000000000008614 241.0
HKD2_k127_4252772_0 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes K06132 GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0090483,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009623 563.0
HKD2_k127_4252772_1 N-terminal domain of oxidoreductase K07119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007024 466.0
HKD2_k127_4252772_2 histone deacetylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 414.0
HKD2_k127_4252772_3 PFAM ATPase associated with various cellular activities, AAA_3 K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005747 416.0
HKD2_k127_4252772_4 Eukaryotic DNA topoisomerase I, catalytic core K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 391.0
HKD2_k127_4252772_5 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000001365 179.0
HKD2_k127_4252772_6 DoxX K15977 - - 0.0000000000000000000000000000000000938 138.0
HKD2_k127_4252772_7 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) K01591 GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 0.000000000000000000002104 96.0
HKD2_k127_4252772_8 nitric oxide dioxygenase activity - - - 0.00000000000000000001529 96.0
HKD2_k127_4266374_0 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.88e-257 826.0
HKD2_k127_4266374_1 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K08295 - 6.2.1.32 2.748e-230 726.0
HKD2_k127_4266374_2 ribosomal rna small subunit methyltransferase - - - 2.408e-201 638.0
HKD2_k127_4266374_3 PFAM acyl-CoA dehydrogenase domain protein K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 481.0
HKD2_k127_4266374_4 Cobalamin-independent synthase, Catalytic domain K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001518 285.0
HKD2_k127_4266374_5 PFAM regulatory protein, MarR - - - 0.000000000000000000000000000000000000000000000000000006418 195.0
HKD2_k127_4266374_6 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.000000000000000000000000000000000000000000000000003834 192.0
HKD2_k127_4266374_7 Endoribonuclease L-PSP - - - 0.0002437 51.0
HKD2_k127_4339532_0 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein K07303 - 1.3.99.16 5.17e-310 972.0
HKD2_k127_4339532_1 aminopeptidase N K01256 - 3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007703 568.0
HKD2_k127_4339532_2 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 559.0
HKD2_k127_4339532_3 cyclic 2,3-diphosphoglycerate synthetase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004741 547.0
HKD2_k127_4339532_4 2Fe-2S -binding domain protein K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000000007666 228.0
HKD2_k127_4339532_5 Periplasmic binding protein K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000001284 245.0
HKD2_k127_4339532_6 - - - - 0.0000000000000002142 87.0
HKD2_k127_4375816_0 VWA domain containing CoxE-like protein K07161 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 448.0
HKD2_k127_4375816_1 Malonyl-CoA decarboxylase K01578 - 4.1.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006784 430.0
HKD2_k127_4375816_2 metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain K07050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008748 279.0
HKD2_k127_4375816_3 AAA domain (dynein-related subfamily) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000072 251.0
HKD2_k127_4375816_4 carbon monoxide dehydrogenase K09386 - - 0.00000000000000000000000000000000000000000000000000003937 194.0
HKD2_k127_4503641_0 TIGRFAM Acetolactate synthase, large subunit, biosynthetic K01652 - 2.2.1.6 1.05e-310 962.0
HKD2_k127_4503641_1 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 590.0
HKD2_k127_4503641_10 dna polymerase III (Chi subunit) K02339 - 2.7.7.7 0.000000000000000000000000000000000002009 158.0
HKD2_k127_4503641_11 RDD family - - - 0.00000000000000000000000000006018 127.0
HKD2_k127_4503641_12 Protein of unknown function (DUF3106) - - - 0.0000000000000000003309 98.0
HKD2_k127_4503641_13 - - - - 0.0000105 53.0
HKD2_k127_4503641_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 571.0
HKD2_k127_4503641_3 Permease YjgP YjgQ family K07091 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000133 374.0
HKD2_k127_4503641_4 Permease, YjgP YjgQ family K11720 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004293 386.0
HKD2_k127_4503641_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008222 329.0
HKD2_k127_4503641_6 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000327 321.0
HKD2_k127_4503641_7 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 309.0
HKD2_k127_4503641_8 RNA polymerase K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006143 248.0
HKD2_k127_4503641_9 Acetolactate synthase small K01653 - 2.2.1.6 0.0000000000000000000000000000000000000000000000000000000000000000001714 256.0
HKD2_k127_4583650_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 5.687e-230 721.0
HKD2_k127_4583650_1 Belongs to the GARS family K01945 - 6.3.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 612.0
HKD2_k127_4583650_10 Bacterial regulatory protein, Fis family K03557 - - 0.000000000000000000003419 99.0
HKD2_k127_4583650_2 aminopeptidase K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 606.0
HKD2_k127_4583650_3 Coproporphyrinogen III oxidase K00228 - 1.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 459.0
HKD2_k127_4583650_4 Phosphotransferase enzyme family K07102 - 2.7.1.221 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002315 428.0
HKD2_k127_4583650_5 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002077 407.0
HKD2_k127_4583650_6 UbiH UbiF VisC COQ6 family K03185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001027 269.0
HKD2_k127_4583650_7 Nucleotidyl transferase K00992 - 2.7.7.99 0.000000000000000000000000000000000000000000000000000000000000004657 235.0
HKD2_k127_4583650_8 HemY domain protein K02498 - - 0.0000000000000000000000000000000000000000001934 167.0
HKD2_k127_4583650_9 - - - - 0.000000000000000000000006729 107.0
HKD2_k127_4865276_0 Thiolase, C-terminal domain - - - 1.052e-205 647.0
HKD2_k127_4865276_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007706 572.0
HKD2_k127_4865276_10 - - - - 0.000000000000000000000000000000000004498 144.0
HKD2_k127_4865276_11 Cupredoxin-like domain - - - 0.000000000000000000000000000000009565 130.0
HKD2_k127_4865276_12 dehydratase - - - 0.0000000000000000000000000196 114.0
HKD2_k127_4865276_13 Belongs to the sulfur carrier protein TusA family - - - 0.0000000000000000000000005476 106.0
HKD2_k127_4865276_2 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001687 356.0
HKD2_k127_4865276_3 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 345.0
HKD2_k127_4865276_4 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000611 317.0
HKD2_k127_4865276_5 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000002488 283.0
HKD2_k127_4865276_6 Nad-dependent epimerase dehydratase K22025 - 1.1.1.410 0.0000000000000000000000000000000000000000000000000000000000000000000000000001148 268.0
HKD2_k127_4865276_7 Iron permease FTR1 family K07243 - - 0.000000000000000000000000000000000000000000000000000002688 195.0
HKD2_k127_4865276_8 KR domain - - - 0.00000000000000000000000000000000000000000000000008761 196.0
HKD2_k127_4865276_9 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000000000000000000000000001451 159.0
HKD2_k127_512585_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 360.0
HKD2_k127_512585_1 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 338.0
HKD2_k127_512585_2 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001029 289.0
HKD2_k127_512585_3 Poly(R)-hydroxyalkanoic acid synthase, class I K03821 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001234 271.0
HKD2_k127_512585_4 Nad-dependent epimerase dehydratase K22025 - 1.1.1.410 0.0000000000000000000000000000007996 124.0
HKD2_k127_5126526_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003288 419.0
HKD2_k127_5126526_1 Transcriptional regulator K21703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 331.0
HKD2_k127_5126526_2 NADH pyrophosphatase-like rudimentary NUDIX domain K03426 - 3.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004056 314.0
HKD2_k127_5126526_3 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site K01601 - 4.1.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 306.0
HKD2_k127_5134056_0 Acetyl-coenzyme A synthetase N-terminus K01907 - 6.2.1.16 3.754e-300 938.0
HKD2_k127_5134056_1 Electron transfer flavoprotein-ubiquinone oxidoreductase K00311 - 1.5.5.1 9.091e-285 886.0
HKD2_k127_5134056_10 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002095 436.0
HKD2_k127_5134056_11 Electron transfer flavoprotein, beta subunit K03521 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004297 395.0
HKD2_k127_5134056_12 CoA-transferase family III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002523 339.0
HKD2_k127_5134056_13 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000002221 283.0
HKD2_k127_5134056_14 Prokaryotic cytochrome b561 K12262 - - 0.0000000000000000000000000000000000000000000000000000000000000000009615 232.0
HKD2_k127_5134056_15 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000001271 234.0
HKD2_k127_5134056_16 LysR substrate binding domain - - - 0.0000000000000000000000000000000000000000000000000000001754 211.0
HKD2_k127_5134056_17 Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions K02553 - - 0.0000000000000000000000000000000000000000000000000002532 189.0
HKD2_k127_5134056_18 PFAM MOSC domain - - - 0.000000000000000000000000000000000000000000000000000652 188.0
HKD2_k127_5134056_19 Thioesterase superfamily K07107 - - 0.00000000000000000000000000000000000002012 148.0
HKD2_k127_5134056_2 Acyl-CoA dehydrogenase N terminal K20035 - - 1.344e-252 792.0
HKD2_k127_5134056_20 Protein of unknown function (DUF962) - - - 0.000000000000000000000000000000000001967 147.0
HKD2_k127_5134056_21 Tripartite tricarboxylate transporter TctB family - - - 0.00000000000000000000000000000000002344 141.0
HKD2_k127_5134056_22 CoA binding domain K09181 - - 0.0000000000000000000000000000000001212 145.0
HKD2_k127_5134056_23 Membrane - - - 0.000000000000000000000000000005569 121.0
HKD2_k127_5134056_24 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.000000000000000000000000000138 116.0
HKD2_k127_5134056_25 EamA-like transporter family - - - 0.0000000000000000000001498 109.0
HKD2_k127_5134056_26 CoA carboxylase activity K01965,K02160 - 6.4.1.3 0.00000000000007158 74.0
HKD2_k127_5134056_3 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP K02837 - - 1.276e-236 742.0
HKD2_k127_5134056_4 Tripartite tricarboxylate transporter TctA family - - - 6.804e-221 694.0
HKD2_k127_5134056_5 PFAM carboxyl transferase - - - 2.253e-213 674.0
HKD2_k127_5134056_6 PFAM Sulfatase K01130 - 3.1.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002951 580.0
HKD2_k127_5134056_7 L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 559.0
HKD2_k127_5134056_8 Amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 506.0
HKD2_k127_5134056_9 Electron transfer flavoprotein, alpha subunit K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004179 453.0
HKD2_k127_5162450_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 5.587e-244 764.0
HKD2_k127_5162450_1 DNA polymerase X family K02347 - - 6e-244 768.0
HKD2_k127_5162450_10 hyperosmotic response K04065 - - 0.0002962 49.0
HKD2_k127_5162450_2 Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) K01622 - 3.1.3.11,4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 557.0
HKD2_k127_5162450_3 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 523.0
HKD2_k127_5162450_4 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005427 439.0
HKD2_k127_5162450_5 PFAM class II aldolase adducin family protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001129 285.0
HKD2_k127_5162450_6 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006464 268.0
HKD2_k127_5162450_7 Nicotinamidase K08281 - 3.5.1.19 0.0000000000000000000000000000000000000000000000000000000000000000006779 235.0
HKD2_k127_5162450_8 Fatty acid hydroxylase superfamily - - - 0.0000000000000000000000000000000000000000000000000000002442 200.0
HKD2_k127_5162450_9 4-carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000000000009273 180.0
HKD2_k127_5166489_0 TIGRFAM ATP-dependent Clp protease ATP-binding subunit clpA K03694 - - 0.0 1187.0
HKD2_k127_5166489_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 6.796e-286 904.0
HKD2_k127_5166489_10 Integral membrane protein TerC family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006216 338.0
HKD2_k127_5166489_11 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008616 343.0
HKD2_k127_5166489_12 to the hyi family K01816 - 5.3.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006499 336.0
HKD2_k127_5166489_13 Belongs to the UPF0758 family K03630 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001731 303.0
HKD2_k127_5166489_14 Histone deacetylase domain K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001199 256.0
HKD2_k127_5166489_15 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000000000000000000002331 228.0
HKD2_k127_5166489_16 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000000000000000000000000000001831 187.0
HKD2_k127_5166489_17 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.0000000000000000000000000000000000000000000000003571 176.0
HKD2_k127_5166489_18 Cold shock K03704 - - 0.0000000000000000000000000000000000164 138.0
HKD2_k127_5166489_19 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000000000000000000005797 121.0
HKD2_k127_5166489_2 TIGRFAM isocitrate dehydrogenase, NADP-dependent K00031 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 2.453e-228 713.0
HKD2_k127_5166489_20 - - - - 0.00000000000000000000009878 102.0
HKD2_k127_5166489_21 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.000000000000000000002311 93.0
HKD2_k127_5166489_22 Protein of unknown function (DUF3108) - - - 0.00000000000000001139 87.0
HKD2_k127_5166489_3 FAD linked oxidases, C-terminal domain K00102,K00104,K03777 - 1.1.2.4,1.1.3.15,1.1.5.12 2.669e-221 695.0
HKD2_k127_5166489_4 glycolate oxidase iron-sulfur subunit K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006625 574.0
HKD2_k127_5166489_5 PFAM fatty acid desaturase K00507 - 1.14.19.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005278 571.0
HKD2_k127_5166489_6 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 475.0
HKD2_k127_5166489_7 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008136 464.0
HKD2_k127_5166489_8 FAD linked oxidase K00104,K11472 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 426.0
HKD2_k127_5166489_9 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K03601,K04564 GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006383 346.0
HKD2_k127_5178731_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 6.255e-198 623.0
HKD2_k127_5178731_1 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001109 511.0
HKD2_k127_5178731_2 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 513.0
HKD2_k127_5178731_3 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000001156 239.0
HKD2_k127_5178731_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000001848 243.0
HKD2_k127_5178731_5 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.0000000000000000000000000000000000000000000000005049 183.0
HKD2_k127_5178731_6 PFAM multiple antibiotic resistance (MarC)-related protein K05595 - - 0.00000000000000000000000000000000000004891 150.0
HKD2_k127_5178731_7 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.00000000000000000000000000000000008694 134.0
HKD2_k127_5178731_8 Protein of unknown function (DUF465) - - - 0.00000000000006419 75.0
HKD2_k127_5178731_9 Endonuclease/Exonuclease/phosphatase family - - - 0.000000005532 59.0
HKD2_k127_5182201_0 Indolepyruvate ferredoxin oxidoreductase K00179 - 1.2.7.8 3.586e-263 821.0
HKD2_k127_5182201_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 584.0
HKD2_k127_5182201_2 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 447.0
HKD2_k127_5182201_3 SMP-30/Gluconolaconase/LRE-like region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001499 300.0
HKD2_k127_5182201_4 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003602 282.0
HKD2_k127_5182201_5 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000003697 261.0
HKD2_k127_5182201_6 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000000000000008187 217.0
HKD2_k127_5182201_7 Sodium Bile acid symporter family - - - 0.00000000000000000000000000000000105 141.0
HKD2_k127_5187993_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 6.477e-315 985.0
HKD2_k127_5187993_1 COG0474 Cation transport ATPase K01531 - 3.6.3.2 4.63e-283 895.0
HKD2_k127_5187993_10 HpcH/HpaI aldolase/citrate lyase family - - - 0.000000000000000000000000000000000000000000000000000000000000000002181 238.0
HKD2_k127_5187993_11 ferredoxin-NADP+ reductase activity - - - 0.000000000000000000000000000000000000000000000000002015 196.0
HKD2_k127_5187993_12 Histidine phosphatase superfamily (branch 1) - - - 0.000000000000000000000000007666 113.0
HKD2_k127_5187993_13 Cytochrome C biogenesis K02200 - - 0.00000000000000000000146 104.0
HKD2_k127_5187993_14 PIN domain - - - 0.000000000000000000001637 105.0
HKD2_k127_5187993_15 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000001531 87.0
HKD2_k127_5187993_2 heat shock protein binding - - - 2.058e-227 731.0
HKD2_k127_5187993_3 Cytochrome c7 and related cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001916 625.0
HKD2_k127_5187993_4 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006872 537.0
HKD2_k127_5187993_5 Domain of unknown function (DUF4139) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004418 487.0
HKD2_k127_5187993_6 Pyridine nucleotide-disulphide oxidoreductase K00384,K21567 - 1.18.1.2,1.19.1.1,1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 331.0
HKD2_k127_5187993_7 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004318 261.0
HKD2_k127_5187993_8 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001168 259.0
HKD2_k127_5187993_9 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009821 250.0
HKD2_k127_5188583_0 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase K01621 - 4.1.2.22,4.1.2.9 0.0 1429.0
HKD2_k127_5188583_1 Glycogen debranching enzyme - - - 0.0 1388.0
HKD2_k127_5188583_2 ) H( ) antiporter that extrudes sodium in exchange for external protons K03313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 459.0
HKD2_k127_5188583_3 Amino acid kinase family K00926 - 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002317 419.0
HKD2_k127_5188583_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006545 247.0
HKD2_k127_5188583_5 - - - - 0.00000000000000000000246 99.0
HKD2_k127_5188583_6 methyltransferase activity - - - 0.000000000000000326 86.0
HKD2_k127_5227322_0 NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding K00336 - 1.6.5.3 1.528e-297 929.0
HKD2_k127_5227322_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 2.988e-249 775.0
HKD2_k127_5227322_10 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000172 253.0
HKD2_k127_5227322_11 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000001218 239.0
HKD2_k127_5227322_12 Fumarate reductase subunit C - - - 0.00000000000000000000000000000003463 137.0
HKD2_k127_5227322_13 Preprotein translocase SecG subunit K03075 - - 0.00000000000000000000000007433 113.0
HKD2_k127_5227322_14 Fumarate reductase subunit D - - - 0.00000000000000002953 87.0
HKD2_k127_5227322_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 2.887e-231 721.0
HKD2_k127_5227322_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008402 429.0
HKD2_k127_5227322_4 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 334.0
HKD2_k127_5227322_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 325.0
HKD2_k127_5227322_6 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009115 321.0
HKD2_k127_5227322_7 Fumarate reductase flavoprotein C-term - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007468 303.0
HKD2_k127_5227322_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 294.0
HKD2_k127_5227322_9 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000001239 253.0
HKD2_k127_5250649_0 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 1.088e-290 918.0
HKD2_k127_5250649_1 Cytochrome D1 heme domain - - - 3.397e-230 729.0
HKD2_k127_5250649_2 Periplasmic binding protein domain - - - 6.278e-203 633.0
HKD2_k127_5250649_3 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001773 469.0
HKD2_k127_5250649_4 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 397.0
HKD2_k127_5250649_5 Major Facilitator Superfamily K19577 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004189 360.0
HKD2_k127_5250649_6 Cyclic nucleotide-monophosphate binding domain K21563 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009534 282.0
HKD2_k127_5250649_7 4Fe-4S single cluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002486 275.0
HKD2_k127_5250649_8 2-hydroxychromene-2-carboxylate isomerase - - - 0.0000000000000000000000000000000000000000000001267 191.0
HKD2_k127_5250649_9 Domain of unknown function (DUF202) K00389 - - 0.00000000000000000000000000000000000000003885 154.0
HKD2_k127_5256386_0 DNA polymerase K02337 - 2.7.7.7 0.0 1411.0
HKD2_k127_5256386_1 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002191 563.0
HKD2_k127_5256386_10 Deoxynucleoside kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000189 292.0
HKD2_k127_5256386_11 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000008411 267.0
HKD2_k127_5256386_12 Iron-containing redox enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000001237 243.0
HKD2_k127_5256386_13 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 0.00000000000000000000000000000000000000000000000000000000000000000002003 244.0
HKD2_k127_5256386_14 Helix-turn-helix domain protein - - - 0.000000000000000000000000000000000000000000000000000006983 203.0
HKD2_k127_5256386_15 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000000000000003294 184.0
HKD2_k127_5256386_16 Belongs to the DnaA family K10763 - - 0.0000000000000000000000000000000000000003296 169.0
HKD2_k127_5256386_17 preprotein translocase subunit YajC K03210 - - 0.00000000000000000000000000000001969 138.0
HKD2_k127_5256386_18 FAD binding domain - - - 0.00000008327 64.0
HKD2_k127_5256386_2 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002017 547.0
HKD2_k127_5256386_3 Histidine Phosphotransfer domain K10715 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006238 558.0
HKD2_k127_5256386_4 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003885 493.0
HKD2_k127_5256386_5 HD domain K13815 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003898 412.0
HKD2_k127_5256386_6 Queuosine biosynthesis protein K07568 - 2.4.99.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005116 400.0
HKD2_k127_5256386_7 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 326.0
HKD2_k127_5256386_8 Pfam Enoyl-CoA hydratase isomerase K13816 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002327 327.0
HKD2_k127_5256386_9 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 306.0
HKD2_k127_5259710_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 2.13e-273 859.0
HKD2_k127_5259710_1 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 2.082e-195 618.0
HKD2_k127_5259710_10 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.0000000000001305 71.0
HKD2_k127_5259710_11 PFAM Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000002982 69.0
HKD2_k127_5259710_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 569.0
HKD2_k127_5259710_3 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 538.0
HKD2_k127_5259710_4 transport protein CorA K03284 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006603 445.0
HKD2_k127_5259710_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004178 410.0
HKD2_k127_5259710_6 PFAM aminotransferase, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001268 390.0
HKD2_k127_5259710_7 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000001899 244.0
HKD2_k127_5259710_8 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.0000000000000000000000000000000000000000000000000009356 197.0
HKD2_k127_5259710_9 Preprotein translocase subunit K03210 - - 0.0000000000000000000000000000000004633 137.0
HKD2_k127_5264807_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K00087,K03520,K04108 - 1.17.1.4,1.2.5.3,1.3.7.9 0.0 1227.0
HKD2_k127_5264807_1 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.0 1169.0
HKD2_k127_5264807_10 AMP-binding enzyme C-terminal domain K00666 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 497.0
HKD2_k127_5264807_11 NAD NADP octopine nopaline dehydrogenase K04940 - 1.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 460.0
HKD2_k127_5264807_12 Receptor family ligand binding region K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003487 432.0
HKD2_k127_5264807_13 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009557 397.0
HKD2_k127_5264807_14 catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003047 372.0
HKD2_k127_5264807_15 catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008299 347.0
HKD2_k127_5264807_16 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002632 362.0
HKD2_k127_5264807_17 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 329.0
HKD2_k127_5264807_18 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008205 304.0
HKD2_k127_5264807_19 protein involved in response to NO K07234 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004543 311.0
HKD2_k127_5264807_2 Hydantoinase/oxoprolinase N-terminal region K01473 - 3.5.2.14 6.716e-283 907.0
HKD2_k127_5264807_20 abc transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001375 300.0
HKD2_k127_5264807_21 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.000000000000000000000000000000000000000000000000000000000000000000001584 263.0
HKD2_k127_5264807_22 GntR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000006731 246.0
HKD2_k127_5264807_23 helix_turn_helix ASNC type K03719 - - 0.0000000000000000000000000000000000000000000000000000000002734 207.0
HKD2_k127_5264807_24 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K05606 - 5.1.99.1 0.0000000000000000000000000000000000000000000000000000001149 201.0
HKD2_k127_5264807_25 B12 binding domain K01849,K20907 - 5.4.99.2,5.4.99.64 0.00000000000000000000000000000000000000000000000000005818 205.0
HKD2_k127_5264807_26 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000000007682 187.0
HKD2_k127_5264807_27 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000006581 158.0
HKD2_k127_5264807_28 - - - - 0.0000000000000001434 87.0
HKD2_k127_5264807_3 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K00074 - 1.1.1.157 3.503e-275 895.0
HKD2_k127_5264807_4 Methylmalonyl-CoA mutase K01847,K01848,K14447,K20906 - 5.4.99.2,5.4.99.63,5.4.99.64 1.429e-270 848.0
HKD2_k127_5264807_5 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 1.507e-210 687.0
HKD2_k127_5264807_6 COG1960 Acyl-CoA dehydrogenases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000154 591.0
HKD2_k127_5264807_7 Thiolase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002308 591.0
HKD2_k127_5264807_8 CoA-transferase family III - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 565.0
HKD2_k127_5264807_9 Hydantoinase B/oxoprolinase K01474 - 3.5.2.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001943 508.0
HKD2_k127_5295685_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00383 - 1.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 526.0
HKD2_k127_5295685_1 COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001913 510.0
HKD2_k127_5295685_10 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000001481 215.0
HKD2_k127_5295685_11 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000002146 150.0
HKD2_k127_5295685_12 VanZ like family - - - 0.000000000000000008982 96.0
HKD2_k127_5295685_13 Protein of unknown function (DUF2917) - - - 0.0000143 51.0
HKD2_k127_5295685_2 cyclopropane-fatty-acyl-phospholipid synthase K00574 - 2.1.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001866 487.0
HKD2_k127_5295685_3 Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 450.0
HKD2_k127_5295685_4 PFAM short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007298 411.0
HKD2_k127_5295685_5 PFAM alanine racemase domain protein K19967 - 4.1.2.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001118 427.0
HKD2_k127_5295685_6 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000013 357.0
HKD2_k127_5295685_7 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 348.0
HKD2_k127_5295685_8 Phosphatidylethanolamine-binding protein K06910 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002335 288.0
HKD2_k127_5295685_9 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000000000000000000000000000000000000003631 216.0
HKD2_k127_5296301_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 4.233e-270 846.0
HKD2_k127_5296301_1 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004282 529.0
HKD2_k127_5296301_2 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 289.0
HKD2_k127_5296301_3 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001532 276.0
HKD2_k127_5296301_4 Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001162 255.0
HKD2_k127_5296301_5 PFAM Lytic transglycosylase catalytic - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002141 255.0
HKD2_k127_5296301_6 Protein of unknown function (DUF3501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004311 249.0
HKD2_k127_5296301_7 Domain in cystathionine beta-synthase and other proteins. - - - 0.00000000000000000000000000000000000000000000000001947 188.0
HKD2_k127_5296301_8 CNP1-like family - - - 0.0000000000000000000000000000000008745 138.0
HKD2_k127_5303216_0 FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 1.035e-270 841.0
HKD2_k127_5303216_1 CobB/CobQ-like glutamine amidotransferase domain K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004301 586.0
HKD2_k127_5303216_2 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001249 508.0
HKD2_k127_5303216_3 Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002782 478.0
HKD2_k127_5303216_4 4Fe-4S dicluster domain K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 357.0
HKD2_k127_5303216_5 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001377 321.0
HKD2_k127_5303216_6 - - - - 0.0000000000000000000000000007003 117.0
HKD2_k127_5303216_7 diguanylate cyclase - - - 0.000000009729 57.0
HKD2_k127_5303216_8 Iron-sulphur cluster biosynthesis K13628 - - 0.00002238 53.0
HKD2_k127_5307318_0 Alpha beta hydrolase K03821 - - 1.312e-232 734.0
HKD2_k127_5307318_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 7.221e-206 653.0
HKD2_k127_5307318_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001847 610.0
HKD2_k127_5307318_3 serine protease K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003675 499.0
HKD2_k127_5307318_4 PFAM band 7 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 369.0
HKD2_k127_5307318_5 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.000000000000000000000000005615 114.0
HKD2_k127_5309468_0 Domain of unknown function (DUF3400) - - - 0.0 1729.0
HKD2_k127_5309468_1 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 - 2.7.11.5 7.161e-217 695.0
HKD2_k127_5309468_10 Histidine kinase K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 420.0
HKD2_k127_5309468_11 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 391.0
HKD2_k127_5309468_12 Pfam Binding-protein-dependent transport systems inner membrane component K02054,K11071 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008363 375.0
HKD2_k127_5309468_13 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 359.0
HKD2_k127_5309468_14 Belongs to the LOG family K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002547 349.0
HKD2_k127_5309468_15 Binding-protein-dependent transport system inner membrane component K11070 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001132 346.0
HKD2_k127_5309468_16 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004352 359.0
HKD2_k127_5309468_17 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006208 338.0
HKD2_k127_5309468_18 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001728 295.0
HKD2_k127_5309468_19 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001762 283.0
HKD2_k127_5309468_2 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 9.539e-216 689.0
HKD2_k127_5309468_20 VanZ like family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002712 267.0
HKD2_k127_5309468_21 Uncharacterised protein family (UPF0093) K08973 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009738 239.0
HKD2_k127_5309468_22 Alpha beta K07018 - - 0.0000000000000000000000000000000000000000000000000000000000000000001024 239.0
HKD2_k127_5309468_23 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000000000000000000001143 200.0
HKD2_k127_5309468_24 Ferredoxin - - - 0.000000000000000000000000000000000000000000000000006451 181.0
HKD2_k127_5309468_25 - - - - 0.0000000000000000000000000000000000000000000000001457 187.0
HKD2_k127_5309468_26 Tim44 - - - 0.0000000000000000000000000000000000000000000000625 179.0
HKD2_k127_5309468_27 integral membrane protein K02221 - - 0.000000000000000000000000000000000000000000002421 171.0
HKD2_k127_5309468_28 HIT domain - - - 0.0000000000000000000000000000000000000000005612 161.0
HKD2_k127_5309468_29 PFAM Class I peptide chain release factor K15034 - - 0.0000000000000000000000000000000000000000007967 162.0
HKD2_k127_5309468_3 twitching motility protein K02670 - - 2.352e-204 642.0
HKD2_k127_5309468_30 protein conserved in bacteria K03690 - - 0.00000000000000000000000000000000001503 143.0
HKD2_k127_5309468_31 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0000000000000000000000000000000538 126.0
HKD2_k127_5309468_32 Protein of unknown function (DUF2782) - - - 0.0000000000000006298 84.0
HKD2_k127_5309468_33 DUF167 K09131 - - 0.000000000000001298 83.0
HKD2_k127_5309468_4 twitching motility protein K02669 - - 1.306e-201 631.0
HKD2_k127_5309468_5 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K11072 - 3.6.3.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 507.0
HKD2_k127_5309468_6 Required for the activity of the bacterial periplasmic transport system of putrescine K02055,K11069 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001091 498.0
HKD2_k127_5309468_7 Isocitrate lyase K01637 - 4.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000433 456.0
HKD2_k127_5309468_8 Belongs to the methyltransferase superfamily K07444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 452.0
HKD2_k127_5309468_9 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 413.0
HKD2_k127_5404072_0 Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps K04084 - 1.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000128 616.0
HKD2_k127_5404072_1 Belongs to the ALAD family K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007625 510.0
HKD2_k127_5404072_10 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000000000000000000001797 198.0
HKD2_k127_5404072_11 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.0000000000000000000000000000000000000000000000000001838 193.0
HKD2_k127_5404072_12 NYN domain - - - 0.000000000000000000000000000000000000000000001064 168.0
HKD2_k127_5404072_13 Secreted repeat of unknown function - - - 0.00000000000000000000000000000000000000000001602 167.0
HKD2_k127_5404072_14 protein involved in tolerance to divalent cations K03926 - - 0.000000000000000000000000000000000000000005834 158.0
HKD2_k127_5404072_15 Catalyzes the formation of 3,6-dideoxy-D-glycero-D-glycero-4-hexulose K00523 - 1.17.1.1 0.000000000000000008526 82.0
HKD2_k127_5404072_2 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003818 501.0
HKD2_k127_5404072_3 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 420.0
HKD2_k127_5404072_4 Oxidoreductase FAD-binding domain K00523 - 1.17.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005591 393.0
HKD2_k127_5404072_5 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 325.0
HKD2_k127_5404072_6 NAD(P)H-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 293.0
HKD2_k127_5404072_7 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004138 263.0
HKD2_k127_5404072_8 cytochrome - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007286 243.0
HKD2_k127_5404072_9 Glyoxalase-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002929 242.0
HKD2_k127_541116_0 PFAM Carbamoyl-phosphate synthase L chain, ATP binding domain, Biotin carboxylase C-terminal domain, Carbamoyl-phosphate synthase L chain, N-terminal domain K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 3.91e-250 776.0
HKD2_k127_541116_1 Methyl-accepting chemotaxis protein K02660 - - 3.176e-223 712.0
HKD2_k127_541116_10 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000005236 264.0
HKD2_k127_541116_11 Response regulator receiver domain - - - 0.0000000000000000000000000000000000000000000000000000000000000007434 221.0
HKD2_k127_541116_12 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000000000000000000054 212.0
HKD2_k127_541116_13 Uncharacterised protein family (UPF0227) K07000 - - 0.000000000000000000000000000000000000000000000000000000005607 205.0
HKD2_k127_541116_14 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000000000000000000000004957 195.0
HKD2_k127_541116_15 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) K00788 - 2.5.1.3 0.00000000000000000000000000000000000000000000000000000924 196.0
HKD2_k127_541116_16 response regulator receiver K02658 - - 0.00000000000000000000000000000000000000000000000000004821 190.0
HKD2_k127_541116_17 - - - - 0.000000000000000000000000000000000000000000000001527 183.0
HKD2_k127_541116_18 PFAM GCN5-related N-acetyltransferase - - - 0.00000000000000000000000000000000000000000003352 168.0
HKD2_k127_541116_19 Chemotaxis signal transduction protein K02659 - - 0.0000000000000000000000000000000000002723 146.0
HKD2_k127_541116_2 Mur ligase family, catalytic domain K02558 - 6.3.2.45 1.176e-198 629.0
HKD2_k127_541116_20 Redoxin family - - - 0.0000000000000000000000000000000001222 139.0
HKD2_k127_541116_21 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.0000000000000000000000000000002309 124.0
HKD2_k127_541116_22 Protein of unknown function (DUF3426) - - - 0.000000000000000000000000001101 122.0
HKD2_k127_541116_3 RNB K01147 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003013 621.0
HKD2_k127_541116_4 Aminotransferase K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009657 599.0
HKD2_k127_541116_5 COG0643 Chemotaxis protein histidine kinase and related kinases K02487,K06596 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006232 425.0
HKD2_k127_541116_6 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006249 402.0
HKD2_k127_541116_7 Ribosomal protein L11 methyltransferase (PrmA) K02687 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 314.0
HKD2_k127_541116_8 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 - 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 302.0
HKD2_k127_541116_9 COG0810 Periplasmic protein TonB, links inner and outer membranes K03832 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000299 287.0
HKD2_k127_5457217_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 7.884e-222 705.0
HKD2_k127_5457217_1 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007414 575.0
HKD2_k127_5457217_2 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004619 306.0
HKD2_k127_5457217_3 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000002202 262.0
HKD2_k127_5457217_4 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000000000000000000002759 253.0
HKD2_k127_5457217_5 nitrite transmembrane transporter activity K08218,K08223 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000001613 177.0
HKD2_k127_5457217_6 PFAM PTS system fructose subfamily IIA component K02821 - 2.7.1.194 0.000000000000000000000000000000000000000000003861 175.0
HKD2_k127_5457217_7 phosphocarrier, HPr family K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000001958 131.0
HKD2_k127_5506984_0 Catalyzes the conversion of salicylyl-CoA to gentisyl-CoA K00219,K09461 - 1.14.13.40,1.3.1.34 3.32e-228 723.0
HKD2_k127_5506984_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006327 610.0
HKD2_k127_5506984_2 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001876 414.0
HKD2_k127_5506984_3 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000002192 259.0
HKD2_k127_5506984_4 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000005067 249.0
HKD2_k127_5506984_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000002933 232.0
HKD2_k127_5516654_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007392 548.0
HKD2_k127_5516654_1 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006806 512.0
HKD2_k127_5516654_2 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 398.0
HKD2_k127_5516654_3 Protein of unknown function (DUF3422) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002688 426.0
HKD2_k127_5516654_4 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008953 375.0
HKD2_k127_5516654_5 NnrU protein - - - 0.000000000000000000000000000000000000000000000000000781 191.0
HKD2_k127_5516654_6 Thioesterase - - - 0.000000000000000000000000000000000000000003126 158.0
HKD2_k127_5516654_7 SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000008364 150.0
HKD2_k127_5537688_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1264.0
HKD2_k127_5537688_1 Belongs to the MurCDEF family K01924 - 6.3.2.8 5.219e-215 686.0
HKD2_k127_5537688_10 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003281 481.0
HKD2_k127_5537688_11 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003738 486.0
HKD2_k127_5537688_12 Domain of unknown function DUF21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000179 452.0
HKD2_k127_5537688_13 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 439.0
HKD2_k127_5537688_14 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929,K15792 - 6.3.2.10,6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001921 455.0
HKD2_k127_5537688_15 Memo-like protein K06990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003275 439.0
HKD2_k127_5537688_16 ATPase (AAA K06923 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001965 396.0
HKD2_k127_5537688_17 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002545 388.0
HKD2_k127_5537688_18 cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007245 372.0
HKD2_k127_5537688_19 AIR synthase related protein, N-terminal domain K00946 - 2.7.4.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008725 359.0
HKD2_k127_5537688_2 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 5.091e-198 631.0
HKD2_k127_5537688_20 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 352.0
HKD2_k127_5537688_21 Thiamine monophosphate synthase K03574 - 3.6.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 349.0
HKD2_k127_5537688_22 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001213 334.0
HKD2_k127_5537688_23 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001726 314.0
HKD2_k127_5537688_24 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002821 282.0
HKD2_k127_5537688_25 PFAM Cytochrome c assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003146 282.0
HKD2_k127_5537688_26 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003327 268.0
HKD2_k127_5537688_27 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000000000000000000000000000001192 239.0
HKD2_k127_5537688_28 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.000000000000000000000000000000000000000000000000000000004272 203.0
HKD2_k127_5537688_29 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.000000000000000000000000000000000000000000000000000007063 204.0
HKD2_k127_5537688_3 type II secretion system protein K02653 - - 1.654e-195 616.0
HKD2_k127_5537688_30 Belongs to the CinA family K03743 - 3.5.1.42 0.000000000000000000000000000000000000000000000000004873 193.0
HKD2_k127_5537688_31 POTRA domain, FtsQ-type - - - 0.0000000000000000000000000000000000000000000002358 177.0
HKD2_k127_5537688_32 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000002288 168.0
HKD2_k127_5537688_33 RimM N-terminal domain K02860 - - 0.0000000000000000000000000000000000002723 146.0
HKD2_k127_5537688_34 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000001752 139.0
HKD2_k127_5537688_35 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.000000000000000000000000000000501 124.0
HKD2_k127_5537688_36 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.00000000000001178 85.0
HKD2_k127_5537688_37 Protein of unknown function (DUF721) - - - 0.00001926 56.0
HKD2_k127_5537688_38 - - - - 0.0006171 45.0
HKD2_k127_5537688_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001245 614.0
HKD2_k127_5537688_5 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000456 573.0
HKD2_k127_5537688_6 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001097 528.0
HKD2_k127_5537688_7 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003175 501.0
HKD2_k127_5537688_8 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 491.0
HKD2_k127_5537688_9 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000166 486.0
HKD2_k127_5581524_0 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 1.396e-284 884.0
HKD2_k127_5581524_1 Belongs to the peptidase M16 family K07263 - - 4.63e-272 863.0
HKD2_k127_5581524_10 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0000000001907 70.0
HKD2_k127_5581524_2 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002041 566.0
HKD2_k127_5581524_3 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002502 466.0
HKD2_k127_5581524_4 Redoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000001113 230.0
HKD2_k127_5581524_5 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - 0.0000000000000000000000000000000000000000000000000000002449 196.0
HKD2_k127_5581524_6 Branched-chain amino acid permease - - - 0.0000000000000000000000000000000000000000000000000001059 194.0
HKD2_k127_5581524_7 OsmC-like protein K04063 GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748 - 0.000000000000000000000000000000000000000000000002014 179.0
HKD2_k127_5581524_8 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.000000000000000002472 85.0
HKD2_k127_5581524_9 branched-chain amino acid - - - 0.0000000000000004305 86.0
HKD2_k127_5890773_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1073.0
HKD2_k127_5890773_1 PFAM aminotransferase class I and II K00832 - 2.6.1.57 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009935 547.0
HKD2_k127_5890773_2 Protein involved in outer membrane biogenesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000008811 244.0
HKD2_k127_5890773_3 Ribonuclease B OB domain K03704 - - 0.00000000000000000000000000004068 119.0
HKD2_k127_5919823_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 2.744e-221 691.0
HKD2_k127_5919823_1 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002297 496.0
HKD2_k127_5919823_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001447 452.0
HKD2_k127_5919823_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001656 359.0
HKD2_k127_5919823_4 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004677 350.0
HKD2_k127_5919823_5 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000003113 257.0
HKD2_k127_5983197_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1054.0
HKD2_k127_5983197_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1052.0
HKD2_k127_5983197_2 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001525 292.0
HKD2_k127_5983197_3 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.000000000000000000000000000000000000000000000000000000000000000000008717 235.0
HKD2_k127_5983197_4 Participates in both transcription termination and antitermination K02600 - - 0.0000000000000000000000000000000000000000002977 160.0
HKD2_k127_5983197_5 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000001639 133.0
HKD2_k127_5983197_6 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000000000000000005825 128.0
HKD2_k127_5983197_7 - - - - 0.000000000000003027 81.0
HKD2_k127_5986322_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 1.092e-223 711.0
HKD2_k127_5986322_1 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000708 558.0
HKD2_k127_5986322_2 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006487 448.0
HKD2_k127_5986322_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000001447 241.0
HKD2_k127_5986322_4 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.000000000000000000000000000000000000000000000000000000000000002345 221.0
HKD2_k127_5986322_5 Yqey-like protein K09117 - - 0.00000000000000000000000000000000000000000000000000008691 189.0
HKD2_k127_5986322_6 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.0000000000000000000000000000000001971 135.0
HKD2_k127_5986322_7 Belongs to the bacterial ribosomal protein bS21 family K02970 - - 0.0000000000000000000000001002 121.0
HKD2_k127_6097951_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1237.0
HKD2_k127_6097951_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 2.035e-203 639.0
HKD2_k127_6097951_10 Transcriptional regulatory protein, C terminal K02483 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001256 253.0
HKD2_k127_6097951_11 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000009054 246.0
HKD2_k127_6097951_12 riboflavin synthase alpha K00793 - 2.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000003183 248.0
HKD2_k127_6097951_13 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000000000001982 211.0
HKD2_k127_6097951_14 Molybdopterin-guanine dinucleotide biosynthesis protein MobA K07141 - 2.7.7.76 0.000000000000000000000000000000000000000000000000000000003168 206.0
HKD2_k127_6097951_15 Branched-chain amino acid transport system / permease component K01997 - - 0.00000000000000000000000000000000000000000000001072 172.0
HKD2_k127_6097951_2 Periplasmic binding protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 539.0
HKD2_k127_6097951_3 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006239 458.0
HKD2_k127_6097951_4 Branched-chain amino acid transport system / permease component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008178 429.0
HKD2_k127_6097951_5 XdhC and CoxI family K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004033 418.0
HKD2_k127_6097951_6 histidine kinase HAMP region domain protein K07649 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000206 377.0
HKD2_k127_6097951_7 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 334.0
HKD2_k127_6097951_8 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003324 273.0
HKD2_k127_6097951_9 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001359 270.0
HKD2_k127_6211563_0 Histidine kinase K02487,K06596 - - 8.337e-299 955.0
HKD2_k127_6211563_1 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001463 593.0
HKD2_k127_6211563_2 dihydroorotase K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 551.0
HKD2_k127_6211563_3 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 512.0
HKD2_k127_6211563_4 Belongs to the UPF0301 (AlgH) family K07735 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000256 274.0
HKD2_k127_6211563_5 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000000003977 135.0
HKD2_k127_6361112_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 3.388e-309 965.0
HKD2_k127_6361112_1 COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase K07478 - - 3.161e-204 644.0
HKD2_k127_6361112_10 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.00000000000000000000000001483 116.0
HKD2_k127_6361112_2 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001509 507.0
HKD2_k127_6361112_3 Peptidogalycan biosysnthesis/recognition K09919 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005296 445.0
HKD2_k127_6361112_4 PFAM Short-chain dehydrogenase reductase SDR K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002372 341.0
HKD2_k127_6361112_5 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 317.0
HKD2_k127_6361112_6 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K10914 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003564 259.0
HKD2_k127_6361112_7 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.00000000000000000000000000000000000000000000000000000000000361 215.0
HKD2_k127_6361112_8 Nitrogen regulatory protein P-II K04751,K04752 - - 0.0000000000000000000000000000000000000000000000000000000002292 204.0
HKD2_k127_6361112_9 Small MutS-related domain - - - 0.000000000000000000000000000000000000000000000000008059 190.0
HKD2_k127_6402672_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 2271.0
HKD2_k127_6402672_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1254.0
HKD2_k127_6402672_10 Enoyl-CoA hydratase carnithine racemase K01692,K11264 - 4.1.1.41,4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000004285 245.0
HKD2_k127_6402672_11 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.00000000000000000000000000000000000000000000000000000000000006195 218.0
HKD2_k127_6402672_12 membrane transporter protein K07090 - - 0.000000000000000002562 94.0
HKD2_k127_6402672_13 lipoprotein - - - 0.0000000002872 68.0
HKD2_k127_6402672_2 chloride channel K03281 - - 4.099e-204 662.0
HKD2_k127_6402672_3 Transcriptional regulator, XRE family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 531.0
HKD2_k127_6402672_4 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001298 483.0
HKD2_k127_6402672_5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 449.0
HKD2_k127_6402672_6 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 402.0
HKD2_k127_6402672_7 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002223 306.0
HKD2_k127_6402672_8 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002571 279.0
HKD2_k127_6402672_9 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001327 262.0
HKD2_k127_6441213_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07239,K15726 - - 0.0 1423.0
HKD2_k127_6441213_1 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 8.874e-224 709.0
HKD2_k127_6441213_2 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 2.547e-212 689.0
HKD2_k127_6441213_3 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 K15461 - 2.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001628 474.0
HKD2_k127_6441213_4 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 351.0
HKD2_k127_6441213_5 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 328.0
HKD2_k127_6441213_6 TIGRFAM efflux transporter, RND family, MFP subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001592 296.0
HKD2_k127_6441213_7 diguanylate cyclase - - - 0.0000000000000000000003462 104.0
HKD2_k127_6441213_8 Protein of unknown function (DUF3240) - - - 0.0000000001013 76.0
HKD2_k127_6446216_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 4.049e-315 978.0
HKD2_k127_6446216_1 Histidine kinase K07646 - 2.7.13.3 3.278e-289 914.0
HKD2_k127_6446216_2 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 2.027e-247 775.0
HKD2_k127_6446216_3 Transcriptional regulatory protein, C terminal K07667 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007462 292.0
HKD2_k127_6446216_4 Pfam:Pyridox_oxidase K07006 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005811 257.0
HKD2_k127_6446216_5 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000006826 221.0
HKD2_k127_6446216_6 Glyoxalase bleomycin resistance - - - 0.000000000000000000000000000000000000000000000000000003707 194.0
HKD2_k127_6446216_7 PD-(D/E)XK nuclease superfamily K01144 - 3.1.11.5 0.000000000000000000000000000000000000000000004686 175.0
HKD2_k127_6446216_8 Domain of unknown function (DUF1330) - - - 0.0000000000000000000000000000000003226 135.0
HKD2_k127_6446216_9 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 0.0000005356 55.0
HKD2_k127_6464614_0 cytochrome C oxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001224 603.0
HKD2_k127_6464614_1 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007292 537.0
HKD2_k127_6464614_10 Pfam Response regulator receiver - - - 0.000000000000000002628 90.0
HKD2_k127_6464614_11 Cytochrome c - - - 0.000000001226 64.0
HKD2_k127_6464614_12 PFAM Cbb3-type cytochrome oxidase component K00407 - - 0.00000003771 58.0
HKD2_k127_6464614_2 Beta-Casp domain K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 543.0
HKD2_k127_6464614_3 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007906 395.0
HKD2_k127_6464614_4 Cytochrome C oxidase, mono-heme subunit/FixO K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001504 319.0
HKD2_k127_6464614_5 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K01420 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004589 306.0
HKD2_k127_6464614_6 PFAM ATP-binding region, ATPase domain protein K02486 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002705 313.0
HKD2_k127_6464614_7 Bacterial regulatory proteins, luxR family - - - 0.0000000000000000000000000000000000000000000000000000000000000003356 233.0
HKD2_k127_6464614_8 FixH K09926 - - 0.00000000000000000000000000000000001316 155.0
HKD2_k127_6464614_9 - - - - 0.000000000000000000001521 97.0
HKD2_k127_6496603_0 FAD binding domain K20940 - 1.14.13.218 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005463 585.0
HKD2_k127_6496603_1 COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 411.0
HKD2_k127_6496603_2 COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001608 317.0
HKD2_k127_6496603_3 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 292.0
HKD2_k127_6496603_4 lactoylglutathione lyase activity K08234 - - 0.0000000000000000000000000000126 128.0
HKD2_k127_6496603_5 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000001486 106.0
HKD2_k127_6496603_6 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases K20940 - 1.14.13.218 0.00000000000000005005 82.0
HKD2_k127_6520130_0 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 1.011e-199 631.0
HKD2_k127_6520130_1 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003429 587.0
HKD2_k127_6520130_10 PFAM Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000005112 168.0
HKD2_k127_6520130_11 Universal stress protein - - - 0.0000000000000000000000000000000000001721 146.0
HKD2_k127_6520130_12 Cyclic nucleotide-monophosphate binding domain K21563 - - 0.000000000000000000000000000000000002455 158.0
HKD2_k127_6520130_13 Invasion gene expression up-regulator SirB - - - 0.000000000000000000000000000000001118 139.0
HKD2_k127_6520130_14 Universal stress protein family - - - 0.0000000000000000000000000000376 123.0
HKD2_k127_6520130_2 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 548.0
HKD2_k127_6520130_3 2-Nitropropane dioxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004901 479.0
HKD2_k127_6520130_4 DnaJ C terminal domain K05516 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000312 329.0
HKD2_k127_6520130_5 Belongs to the 'phage' integrase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004223 273.0
HKD2_k127_6520130_6 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003716 262.0
HKD2_k127_6520130_7 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029 - - 0.0000000000000000000000000000000000000000000000000000000000007845 213.0
HKD2_k127_6520130_8 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.000000000000000000000000000000000000000000000000000002447 198.0
HKD2_k127_6520130_9 CoA-binding domain protein K09181 - - 0.000000000000000000000000000000000000000000000001325 179.0
HKD2_k127_6524035_0 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor K00697 - 2.4.1.15,2.4.1.347 1.813e-304 955.0
HKD2_k127_6524035_1 PFAM Glycoside hydrolase 15-related - - - 3.924e-257 821.0
HKD2_k127_6524035_10 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000000000000000000000000000000000000000000000000000000000000000008513 261.0
HKD2_k127_6524035_11 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001941 261.0
HKD2_k127_6524035_12 Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000158 235.0
HKD2_k127_6524035_13 Removes the phosphate from trehalose 6-phosphate to produce free trehalose K01087 - 3.1.3.12 0.0000000000000000000000000000000000000000000000000000000000000001743 235.0
HKD2_k127_6524035_14 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000127 226.0
HKD2_k127_6524035_15 PFAM electron transport protein SCO1 SenC K07152 - - 0.00000000000000000000000000000000000000000000000000000000006503 225.0
HKD2_k127_6524035_16 - - - - 0.00000000000000000000000000000000000001535 154.0
HKD2_k127_6524035_18 - - - - 0.00000000001049 68.0
HKD2_k127_6524035_19 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.0005371 47.0
HKD2_k127_6524035_2 PFAM Cytochrome c oxidase, subunit I K02274 - 1.9.3.1 5.911e-251 785.0
HKD2_k127_6524035_3 Cytochrome b(N-terminal)/b6/petB - - - 1.872e-243 768.0
HKD2_k127_6524035_4 MoeA N-terminal region (domain I and II) K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 545.0
HKD2_k127_6524035_5 Methyl-viologen-reducing hydrogenase, delta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 488.0
HKD2_k127_6524035_6 Cytochrome C and Quinol oxidase polypeptide I - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 486.0
HKD2_k127_6524035_7 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002379 294.0
HKD2_k127_6524035_8 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003555 283.0
HKD2_k127_6524035_9 cytochrome c oxidase (Subunit II) K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000973 268.0
HKD2_k127_6526413_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 0.0 1068.0
HKD2_k127_6526413_1 Acid phosphatase homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000008102 237.0
HKD2_k127_6526413_2 LPPG Fo 2-phospho-L-lactate transferase K11212 - 2.7.8.28 0.0000000000000000000000000000000001062 137.0
HKD2_k127_6526413_3 cold-shock protein K03704 - - 0.0000000000000000000000000000005328 123.0
HKD2_k127_6544864_0 Zinc-binding dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000466 477.0
HKD2_k127_6544864_1 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001073 430.0
HKD2_k127_6544864_2 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000501 352.0
HKD2_k127_6544864_3 NUDIX domain - - - 0.000000000000000000000000000000000000000000000000000000000008102 216.0
HKD2_k127_6544864_4 - - - - 0.00000000000000000000001214 106.0
HKD2_k127_6544864_5 - - - - 0.00000001093 59.0
HKD2_k127_6596174_0 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006162 616.0
HKD2_k127_6596174_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000329 562.0
HKD2_k127_6596174_10 PFAM response regulator receiver K11443 - - 0.000000000000000000000000000000325 132.0
HKD2_k127_6596174_2 Serine aminopeptidase, S33 K01253,K08253 - 2.7.10.2,3.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005731 494.0
HKD2_k127_6596174_3 Belongs to the adenylyl cyclase class-4 guanylyl cyclase family K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003014 463.0
HKD2_k127_6596174_4 GAF domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 396.0
HKD2_k127_6596174_5 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003715 352.0
HKD2_k127_6596174_6 transport system periplasmic component K01989 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006884 340.0
HKD2_k127_6596174_7 ABC transporter substrate binding protein K01989 - - 0.000000000000000000000000000000000000000000000000000000000008786 221.0
HKD2_k127_6596174_8 SMART cyclic nucleotide-binding K10914 - - 0.0000000000000000000000000000000000000000000000000000006428 200.0
HKD2_k127_6596174_9 Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily K00001,K00121 - 1.1.1.1,1.1.1.284 0.00000000000000000000000000000000000000000000002634 173.0
HKD2_k127_6639281_0 Pyruvate ferredoxin/flavodoxin oxidoreductase K04090 - 1.2.7.8 0.0 1108.0
HKD2_k127_6639281_1 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001569 282.0
HKD2_k127_6639281_2 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000983 275.0
HKD2_k127_6689668_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 3.258e-233 736.0
HKD2_k127_6689668_1 TonB dependent receptor K02014 - - 9.708e-199 643.0
HKD2_k127_6689668_10 - - - - 0.00000000000000000000000000000000001096 138.0
HKD2_k127_6689668_11 Permeases of the major facilitator superfamily - - - 0.0000000000000001867 91.0
HKD2_k127_6689668_12 EamA-like transporter family - - - 0.0000001592 62.0
HKD2_k127_6689668_2 Psort location Cytoplasmic, score 7.50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001779 528.0
HKD2_k127_6689668_3 Acyl-CoA dehydrogenase, C-terminal domain K11731 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005953 528.0
HKD2_k127_6689668_4 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005605 495.0
HKD2_k127_6689668_5 maleylacetate reductase K00217 - 1.3.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006088 449.0
HKD2_k127_6689668_6 Permeases of the major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005176 331.0
HKD2_k127_6689668_7 PFAM Carbohydrate-selective porin OprB K07267 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 299.0
HKD2_k127_6689668_8 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007272 250.0
HKD2_k127_6689668_9 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000327 188.0
HKD2_k127_6738225_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 1.007e-295 912.0
HKD2_k127_6738225_1 GTP-binding protein K06207 - - 4.592e-289 902.0
HKD2_k127_6738225_10 Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 452.0
HKD2_k127_6738225_11 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005832 445.0
HKD2_k127_6738225_12 Nitronate monooxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002173 438.0
HKD2_k127_6738225_13 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005353 419.0
HKD2_k127_6738225_14 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002394 396.0
HKD2_k127_6738225_15 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006438 401.0
HKD2_k127_6738225_16 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004357 380.0
HKD2_k127_6738225_17 COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3 K02276 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001199 378.0
HKD2_k127_6738225_18 RNA polymerase sigma K03089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003212 358.0
HKD2_k127_6738225_19 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001966 352.0
HKD2_k127_6738225_2 PFAM AMP-dependent synthetase K01895 - 6.2.1.1 1.167e-260 819.0
HKD2_k127_6738225_20 COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 K21029 - 2.7.7.80 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002145 342.0
HKD2_k127_6738225_21 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002877 325.0
HKD2_k127_6738225_22 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005963 323.0
HKD2_k127_6738225_23 Peptidase family M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005588 287.0
HKD2_k127_6738225_24 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001892 269.0
HKD2_k127_6738225_25 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.000000000000000000000000000000000000000000000000000000000000000000000000008754 265.0
HKD2_k127_6738225_26 Involved in biogenesis of respiratory and photosynthetic systems K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002742 257.0
HKD2_k127_6738225_27 oxidase assembly K02258 - - 0.000000000000000000000000000000000000000000000000000000000000000000000236 244.0
HKD2_k127_6738225_28 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003539 246.0
HKD2_k127_6738225_29 Pyrimidine 5''-nucleotidase K07025 - - 0.000000000000000000000000000000000000000000000000000000000000000000006483 254.0
HKD2_k127_6738225_3 Peptidase M1 membrane alanine aminopeptidase - - - 4.018e-223 715.0
HKD2_k127_6738225_30 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.00000000000000000000000000000000000000000000000000000000000000000001826 235.0
HKD2_k127_6738225_31 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.00000000000000000000000000000000000000000000000000000000000000000308 228.0
HKD2_k127_6738225_32 Bacterial regulatory proteins, tetR family K05501 - - 0.0000000000000000000000000000000000000000000000000000000000000002114 226.0
HKD2_k127_6738225_33 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000000000000000000009543 233.0
HKD2_k127_6738225_34 SURF1-like protein K14998 - - 0.0000000000000000000000000000000000000000000000000000000000002775 220.0
HKD2_k127_6738225_35 PFAM Phosphoribosyltransferase - - - 0.00000000000000000000000000000000000000000000000000001438 203.0
HKD2_k127_6738225_36 Conserved hypothetical protein 95 K08316 - 2.1.1.171 0.0000000000000000000000000000000000000000000000000000985 192.0
HKD2_k127_6738225_37 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.00000000000000000000000000000000000000000000000001954 187.0
HKD2_k127_6738225_38 transcriptional - - - 0.0000000000000000000000000000000000000000000004251 168.0
HKD2_k127_6738225_39 signal sequence binding - - - 0.000000000000000000000000000000000000000001232 168.0
HKD2_k127_6738225_4 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 591.0
HKD2_k127_6738225_40 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000007998 158.0
HKD2_k127_6738225_41 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.0000000000000000000000000000000000001002 151.0
HKD2_k127_6738225_42 Bacterial SH3 domain - - - 0.000000000000000000000000000000001348 141.0
HKD2_k127_6738225_43 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000002268 137.0
HKD2_k127_6738225_44 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.000000000000000000000000000001853 124.0
HKD2_k127_6738225_45 Integral membrane protein (DUF2244) - - - 0.000000000000000166 87.0
HKD2_k127_6738225_46 Protein of unknown function (DUF2909) - - - 0.00000000001686 71.0
HKD2_k127_6738225_47 Glycine zipper 2TM domain - - - 0.000000005776 64.0
HKD2_k127_6738225_48 Protein of unknown function (DUF2970) - - - 0.00002447 55.0
HKD2_k127_6738225_49 - - - - 0.0001917 53.0
HKD2_k127_6738225_5 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003043 554.0
HKD2_k127_6738225_6 belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000869 535.0
HKD2_k127_6738225_7 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001226 548.0
HKD2_k127_6738225_8 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 501.0
HKD2_k127_6738225_9 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003235 441.0
HKD2_k127_680238_0 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 521.0
HKD2_k127_680238_1 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001695 326.0
HKD2_k127_680238_10 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000000000000000000000000000000002068 166.0
HKD2_k127_680238_11 Uncharacterized ACR, COG1993 - - - 0.0000000000000000000000000000000531 128.0
HKD2_k127_680238_12 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.000000000000000001243 96.0
HKD2_k127_680238_2 PFAM ABC transporter related K02049,K15555,K15578 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000674 304.0
HKD2_k127_680238_3 Binding protein dependent transporter membrane component K05773,K06857 - 3.6.3.55 0.00000000000000000000000000000000000000000000000000000000000000000000005981 246.0
HKD2_k127_680238_4 COG0725 ABC-type molybdate transport system, periplasmic component K02020 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008203 247.0
HKD2_k127_680238_5 Molybdate K02018 - - 0.000000000000000000000000000000000000000000000000000000000000000000001839 240.0
HKD2_k127_680238_6 PBP superfamily domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002793 235.0
HKD2_k127_680238_7 molybdopterin-guanine dinucleotide biosynthesis protein b K03753 - - 0.0000000000000000000000000000000000000000000000000000000000005059 226.0
HKD2_k127_680238_8 ATPases associated with a variety of cellular activities K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000005256 225.0
HKD2_k127_680238_9 MoaE protein K03635 - 2.8.1.12 0.00000000000000000000000000000000000000000000000000000247 194.0
HKD2_k127_6893036_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1587.0
HKD2_k127_6893036_1 Belongs to the binding-protein-dependent transport system permease family K01997,K01998 - - 1.044e-249 786.0
HKD2_k127_6893036_10 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 340.0
HKD2_k127_6893036_11 ABC transporter K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002215 332.0
HKD2_k127_6893036_12 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006416 336.0
HKD2_k127_6893036_13 DNA polymerase alpha chain like domain K07053 GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657 3.1.3.97 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 319.0
HKD2_k127_6893036_14 Belongs to the SUA5 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003349 286.0
HKD2_k127_6893036_15 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase K19200 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004349 289.0
HKD2_k127_6893036_16 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000268 272.0
HKD2_k127_6893036_17 NADH dehydrogenase NAD(P)H nitroreductase K09019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004383 268.0
HKD2_k127_6893036_18 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001558 285.0
HKD2_k127_6893036_19 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008129 258.0
HKD2_k127_6893036_2 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 576.0
HKD2_k127_6893036_20 Domain of unknown function (DUF3391) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005809 263.0
HKD2_k127_6893036_21 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000001722 245.0
HKD2_k127_6893036_22 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - 0.000000000000000000000000000000000000000000000000000000000005417 212.0
HKD2_k127_6893036_23 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K10715 - 2.7.13.3 0.00000000000000000000000000000003922 132.0
HKD2_k127_6893036_24 cheY-homologous receiver domain - - - 0.00000000000000000000000000000006228 135.0
HKD2_k127_6893036_3 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0000183,GO:0001302,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007568,GO:0007569,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0016874,GO:0016879,GO:0018130,GO:0019219,GO:0019222,GO:0019357,GO:0019358,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032502,GO:0034641,GO:0034654,GO:0040029,GO:0043094,GO:0043173,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046497,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0051276,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 580.0
HKD2_k127_6893036_4 D-amino acid dehydrogenase K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 486.0
HKD2_k127_6893036_5 Acetyl-CoA hydrolase/transferase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 455.0
HKD2_k127_6893036_6 Permeases of the major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006693 408.0
HKD2_k127_6893036_7 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008562 366.0
HKD2_k127_6893036_8 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007999 361.0
HKD2_k127_6893036_9 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004316 353.0
HKD2_k127_6899577_0 TIGRFAM formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.0 1428.0
HKD2_k127_6899577_1 Formate--tetrahydrofolate ligase K01938 - 6.3.4.3 1.801e-286 889.0
HKD2_k127_6899577_10 PFAM Glutamine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000269 276.0
HKD2_k127_6899577_11 Integral membrane protein TerC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002492 248.0
HKD2_k127_6899577_12 Enoyl-(Acyl carrier protein) reductase K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000006389 226.0
HKD2_k127_6899577_13 Protein of unknown function (DUF2889) - - - 0.0000000000000000000000000000000000000000000000000000000001478 231.0
HKD2_k127_6899577_14 Sugar-transfer associated ATP-grasp - - - 0.0000000000000000000000000000000000000000000000000000003245 197.0
HKD2_k127_6899577_15 OsmC-like protein - - - 0.0000000000000000000000000000000000000001854 156.0
HKD2_k127_6899577_16 - - - - 0.0000000000000000000000001506 120.0
HKD2_k127_6899577_17 cyclic nucleotide-binding - GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - 0.00000005712 64.0
HKD2_k127_6899577_18 cyclic nucleotide-binding - - - 0.00000922 57.0
HKD2_k127_6899577_2 24 kD subunit K00122 - 1.17.1.9 5.146e-267 834.0
HKD2_k127_6899577_3 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 5.399e-217 683.0
HKD2_k127_6899577_4 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 1.015e-194 617.0
HKD2_k127_6899577_5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013 6.2.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001088 511.0
HKD2_k127_6899577_6 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005737 490.0
HKD2_k127_6899577_7 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003825 453.0
HKD2_k127_6899577_8 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 330.0
HKD2_k127_6899577_9 glutamine amidotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005197 329.0
HKD2_k127_6932029_0 PFAM AMP-dependent synthetase and ligase K04116 - - 3.804e-235 746.0
HKD2_k127_6932029_1 AMP-binding enzyme C-terminal domain - - - 9.871e-226 715.0
HKD2_k127_6932029_10 DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA K05982 - 3.1.21.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 302.0
HKD2_k127_6932029_11 ATPases associated with a variety of cellular activities K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002339 288.0
HKD2_k127_6932029_12 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009823 269.0
HKD2_k127_6932029_13 COG0410 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003141 267.0
HKD2_k127_6932029_14 Peptidyl-prolyl cis-trans K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000001261 201.0
HKD2_k127_6932029_15 Glutaredoxin - - - 0.000000000000000000000000000000000000000000004497 166.0
HKD2_k127_6932029_16 - - - - 0.0000000000000000000000005824 113.0
HKD2_k127_6932029_2 abc transporter K15738 - - 5.658e-203 647.0
HKD2_k127_6932029_3 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 592.0
HKD2_k127_6932029_4 Periplasmic binding protein domain K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006496 518.0
HKD2_k127_6932029_5 Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily K01661,K07536 - 4.1.3.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 458.0
HKD2_k127_6932029_6 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 370.0
HKD2_k127_6932029_7 Alcohol dehydrogenase GroES-like domain K00001,K00344 - 1.1.1.1,1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007739 353.0
HKD2_k127_6932029_8 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001233 333.0
HKD2_k127_6932029_9 Branched-chain amino acid transport system / permease component K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004077 308.0
HKD2_k127_6940637_0 MMPL family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001102 546.0
HKD2_k127_6940637_1 Belongs to the beta-ketoacyl-ACP synthases family K00647 - 2.3.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001865 484.0
HKD2_k127_6940637_10 Beta-ketoacyl synthase, N-terminal domain - - - 0.00000000000000000000000000000000000000000000000000002014 198.0
HKD2_k127_6940637_11 dehydratase - - - 0.0000000000000000000000000000000001427 139.0
HKD2_k127_6940637_12 Diguanylate cyclase - - - 0.000000000000000000000000000000006536 144.0
HKD2_k127_6940637_13 pathogenesis - - - 0.00000000000000000000000000002986 125.0
HKD2_k127_6940637_14 Phosphopantetheine attachment site K02078 - - 0.00000000000000000000000004387 114.0
HKD2_k127_6940637_15 membrane - - - 0.000000000000002446 84.0
HKD2_k127_6940637_16 Fatty acyl CoA synthetase - - - 0.000000000000005969 83.0
HKD2_k127_6940637_17 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit K01738,K01883,K12339 - 2.5.1.47,6.1.1.16 0.00000000000213 69.0
HKD2_k127_6940637_18 dehydratase - - - 0.000000000003472 76.0
HKD2_k127_6940637_19 Cache domain - - - 0.00000000008438 74.0
HKD2_k127_6940637_2 AMP-binding enzyme C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003884 359.0
HKD2_k127_6940637_20 protein conserved in bacteria - - - 0.00000002883 59.0
HKD2_k127_6940637_4 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 293.0
HKD2_k127_6940637_5 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001364 275.0
HKD2_k127_6940637_6 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002863 269.0
HKD2_k127_6940637_7 Bacterial lipid A biosynthesis acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004534 277.0
HKD2_k127_6940637_8 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000006085 234.0
HKD2_k127_6940637_9 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000002651 228.0
HKD2_k127_7059963_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 1.298e-209 663.0
HKD2_k127_7059963_1 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001538 459.0
HKD2_k127_7059963_2 Orn/Lys/Arg decarboxylase, C-terminal domain K01583 - 4.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001468 435.0
HKD2_k127_7059963_3 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001239 251.0
HKD2_k127_7059963_4 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000001219 93.0
HKD2_k127_7059963_5 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit K03299 - - 0.000000000000002502 78.0
HKD2_k127_7120137_0 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 2.203e-195 623.0
HKD2_k127_7120137_1 surface antigen variable number repeat protein K07001 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000127 586.0
HKD2_k127_7120137_10 Binds single-stranded DNA at the primosome assembly site (PAS) K02686 - - 0.00000000000000000001232 95.0
HKD2_k127_7120137_11 - - - - 0.000000000008049 69.0
HKD2_k127_7120137_12 AsmA family K07290 - - 0.00000001147 69.0
HKD2_k127_7120137_2 surface antigen K07278 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005455 425.0
HKD2_k127_7120137_3 protein conserved in bacteria K09800 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007817 421.0
HKD2_k127_7120137_4 Large family of predicted nucleotide-binding domains K07175 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 346.0
HKD2_k127_7120137_5 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 344.0
HKD2_k127_7120137_6 Binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000000000000000000000000051 213.0
HKD2_k127_7120137_7 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000000000000000000000000000000000000000000000007225 206.0
HKD2_k127_7120137_8 - - - - 0.0000000000000000000000000000000000000002438 155.0
HKD2_k127_7120137_9 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.00000000000000000000000000000000001116 137.0
HKD2_k127_7281705_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 3.92e-292 906.0
HKD2_k127_7281705_1 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005951 406.0
HKD2_k127_7281705_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009572 403.0
HKD2_k127_7281705_3 Protein of unknown function (DUF502) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 301.0
HKD2_k127_7281705_4 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000003172 212.0
HKD2_k127_7281705_5 Ribonuclease K01167 - 3.1.27.3 0.000000000000000000000000002004 129.0
HKD2_k127_7281705_6 Putative regulatory protein - - - 0.000000000000000000000001506 112.0
HKD2_k127_7281705_7 Barstar (barnase inhibitor) - - - 0.000000000000000000000001537 111.0
HKD2_k127_743445_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K07303 - 1.3.99.16 2.228e-255 810.0
HKD2_k127_743445_1 S-adenosylmethionine synthetase (AdoMet synthetase) K00789 - 2.5.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 442.0
HKD2_k127_743445_10 - - - - 0.00000000000000001761 89.0
HKD2_k127_743445_11 Protein of unknown function (DUF2384) - - - 0.00000002362 63.0
HKD2_k127_743445_12 Protein of unknown function (DUF2934) - - - 0.0002429 45.0
HKD2_k127_743445_2 Peptidase family M28 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004867 326.0
HKD2_k127_743445_3 Phage plasmid primase P4 family K06919 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 318.0
HKD2_k127_743445_4 Saccharopine dehydrogenase K03340 - 1.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008362 282.0
HKD2_k127_743445_5 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.00000000000000000000000000000000000000000000000000000000000004052 219.0
HKD2_k127_743445_6 Phosphoribosyl transferase domain - - - 0.0000000000000000000000000000000000000000000000000000002262 197.0
HKD2_k127_743445_7 GYD domain - - - 0.000000000000000000000000000000000001125 140.0
HKD2_k127_743445_8 ribosomal large subunit export from nucleus - - - 0.00000000000000000000001025 102.0
HKD2_k127_743445_9 Protein of unknown function (DUF504) - - - 0.00000000000000000001205 106.0
HKD2_k127_750434_0 flavoprotein involved in K transport - - - 1.664e-203 644.0
HKD2_k127_750434_1 Domain of unknown function (DUF4139) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006827 467.0
HKD2_k127_750434_2 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components K02051 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003532 435.0
HKD2_k127_750434_3 ATPases associated with a variety of cellular activities K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000337 334.0
HKD2_k127_750434_4 Binding-protein-dependent transport system inner membrane component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000341 310.0
HKD2_k127_750434_5 Protein conserved in bacteria K09983 - - 0.0000000000000000000000000000000000000000000000000000000000006794 220.0
HKD2_k127_750434_6 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.000000000003858 78.0
HKD2_k127_7730963_0 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000391 470.0
HKD2_k127_7730963_1 FtsX-like permease family K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003976 461.0
HKD2_k127_7730963_2 Methyl-transferase K18912 - 1.14.99.50 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 418.0
HKD2_k127_7730963_3 Rhodanese Homology Domain K06917 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006142 401.0
HKD2_k127_7730963_4 ABC transporter K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 303.0
HKD2_k127_7730963_5 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001938 275.0
HKD2_k127_7730963_6 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000434 224.0
HKD2_k127_7730963_7 GDSL-like Lipase/Acylhydrolase K10804 - 3.1.1.5 0.0000000000000000000000000000000000000000000000000000000008622 228.0
HKD2_k127_7730963_8 Multidrug ABC transporter ATP-binding protein K01990 - - 0.0000000000005533 69.0
HKD2_k127_7768250_0 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001093 562.0
HKD2_k127_7768250_1 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006283 488.0
HKD2_k127_7768250_2 Transglutaminase/protease-like homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006889 462.0
HKD2_k127_7768250_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 396.0
HKD2_k127_7768250_4 Acyl-CoA dehydrogenase, middle domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000006323 242.0
HKD2_k127_7768250_5 Bacterial extracellular solute-binding protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000006124 236.0
HKD2_k127_7768250_6 Protein of unknown function (DUF3305) - - - 0.0000000000000000000000000000000000893 139.0
HKD2_k127_7768250_7 Protein of unknown function (DUF3306) - - - 0.000000000004483 79.0
HKD2_k127_7777574_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K18361 - 1.17.5.1,3.1.2.25 0.0 1252.0
HKD2_k127_7777574_1 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001793 385.0
HKD2_k127_7777574_2 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008811 380.0
HKD2_k127_7777574_3 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004541 324.0
HKD2_k127_7777574_4 branched-chain amino acid transport K01995,K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 323.0
HKD2_k127_7777574_5 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000001706 228.0
HKD2_k127_7777574_6 Thioesterase - - - 0.000000000000000000000000000000000000000000005833 169.0
HKD2_k127_7777574_7 PFAM Extracellular ligand-binding receptor K01999 - - 0.0000000000000000000000000000000000000002128 151.0
HKD2_k127_7778630_0 AcrB/AcrD/AcrF family K03296 - - 0.0 1255.0
HKD2_k127_7778630_1 type I secretion outer membrane protein, TolC K12340 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001076 427.0
HKD2_k127_7778630_2 3-Deoxy-D-manno-octulosonic-acid transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 411.0
HKD2_k127_7778630_3 Glycosyltransferase family 9 (heptosyltransferase) K02841 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 304.0
HKD2_k127_7778630_4 Ribosomal RNA adenine dimethylase K00573 - 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 284.0
HKD2_k127_7778630_5 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006147 287.0
HKD2_k127_7778630_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001922 278.0
HKD2_k127_7778630_7 PFAM Rhodanese domain protein - - - 0.000000000000000000000000000000000000003035 148.0
HKD2_k127_7778630_8 Bacterial transcriptional repressor C-terminal K09017 - - 0.000000000000005412 77.0
HKD2_k127_7931618_0 Sugar (and other) transporter - - - 1.942e-255 798.0
HKD2_k127_7931618_1 Putative modulator of DNA gyrase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000685 577.0
HKD2_k127_7931618_10 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 424.0
HKD2_k127_7931618_11 Peptidase dimerisation domain K01438,K01439 - 3.5.1.16,3.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 384.0
HKD2_k127_7931618_12 PFAM beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003519 335.0
HKD2_k127_7931618_13 PFAM secretion protein HlyD family protein K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003752 308.0
HKD2_k127_7931618_14 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003745 278.0
HKD2_k127_7931618_15 PFAM Metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000008457 261.0
HKD2_k127_7931618_16 membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000007782 227.0
HKD2_k127_7931618_17 TIGRFAM exopolysaccharide biosynthesis operon protein EpsL - - - 0.0000000000000000000000000000000000000000000000000000000001582 220.0
HKD2_k127_7931618_18 Domain of unknown function (DUF4337) - - - 0.00000000000000000000000000000000000000000000001935 179.0
HKD2_k127_7931618_19 Bacterial regulatory proteins, luxR family - - - 0.0000000000000000000000000000000000000000002478 173.0
HKD2_k127_7931618_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 559.0
HKD2_k127_7931618_20 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000000000000000000000000005642 164.0
HKD2_k127_7931618_21 metal-dependent hydrolase of the TIM-barrel fold - - - 0.0000000000000000000000000000000000000007991 160.0
HKD2_k127_7931618_22 Transcription regulator that can specifically activate or repress expression of target genes K06075 - - 0.00000000000000000000006199 104.0
HKD2_k127_7931618_3 major facilitator superfamily K03446 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 546.0
HKD2_k127_7931618_4 Bacterial sugar transferase K03606 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 539.0
HKD2_k127_7931618_5 Major Facilitator Superfamily K08169 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004973 516.0
HKD2_k127_7931618_6 Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) K05365,K05366 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008769 495.0
HKD2_k127_7931618_7 aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001984 486.0
HKD2_k127_7931618_8 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007399 469.0
HKD2_k127_7931618_9 Putative modulator of DNA gyrase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 441.0
HKD2_k127_7980760_0 ABC-type transport system involved in resistance to organic solvents, permease component K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 402.0
HKD2_k127_7980760_1 Abc transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 376.0
HKD2_k127_7980760_2 KR domain K00065 - 1.1.1.127 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000082 361.0
HKD2_k127_7980760_3 Protein of unknown function (DUF3300) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003155 319.0
HKD2_k127_7980760_4 PFAM Mammalian cell entry related domain protein K02067 - - 0.0000000000000000000000000000000000000000000000000000000000001657 233.0
HKD2_k127_7980760_5 Glycine-zipper domain - - - 0.000000000000000000000000000000000000000000000002928 178.0
HKD2_k127_7980760_6 ABC-type transport auxiliary lipoprotein component K18480 - - 0.0000000000000000000000000000000007808 145.0
HKD2_k127_7980760_7 - - - - 0.0000000000000000000001999 102.0
HKD2_k127_7980760_8 - - - - 0.000000000000002728 78.0
HKD2_k127_7980760_9 hyperosmotic response K04065 GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - 0.00000000001137 71.0
HKD2_k127_8002562_0 COG1132 ABC-type multidrug transport system, ATPase and permease components K06147 - - 1.177e-206 658.0
HKD2_k127_8002562_1 Substrate binding domain of ABC-type glycine betaine transport system K05845,K05846 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009398 521.0
HKD2_k127_8002562_2 SMART PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001025 294.0
HKD2_k127_8002562_3 PFAM histone deacetylase superfamily K04768 - - 0.000000000000000000000000000000000000000000000000000000000000177 215.0
HKD2_k127_8002562_4 NAD(P) transhydrogenase, alpha subunit K00324 - 1.6.1.2 0.0000000001058 63.0
HKD2_k127_8018620_0 poly(R)-hydroxyalkanoic acid synthase K03821 - - 7.768e-263 836.0
HKD2_k127_8018620_1 Zn-dependent hydrolases including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002113 317.0
HKD2_k127_8018620_2 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000225 279.0
HKD2_k127_8018620_3 Arginyl-tRNA synthetase K01887 - 6.1.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000001772 250.0
HKD2_k127_8018620_4 Thiol disulfide interchange protein K03673 - - 0.0000000000000000000000000000000000000000000002393 175.0
HKD2_k127_8018620_5 PFAM Sporulation domain protein - - - 0.00000000000000000000000000000000000000000001471 169.0
HKD2_k127_8023518_0 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 4.309e-227 707.0
HKD2_k127_8023518_1 AMP-dependent synthetase and ligase K00666 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0051087 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008815 542.0
HKD2_k127_8023518_2 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 396.0
HKD2_k127_8023518_3 PFAM NPCBM-associated, NEW3 domain of alpha-galactosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001942 360.0
HKD2_k127_8023518_4 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 356.0
HKD2_k127_8023518_5 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002751 308.0
HKD2_k127_8023518_6 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000000000000000000006392 207.0
HKD2_k127_8023518_7 involved in cell wall biogenesis K00721 - 2.4.1.83 0.00000000000000000000000000000000002661 139.0
HKD2_k127_8083983_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 0.0 1164.0
HKD2_k127_8083983_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 1.48e-197 642.0
HKD2_k127_8083983_10 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000000000000001935 220.0
HKD2_k127_8083983_11 dehydratase - - - 0.000000000000000000000000000000000000000000000000000002219 196.0
HKD2_k127_8083983_12 NUDIX domain K08310 - 3.6.1.67 0.0000000000000000000000000000000000000000000000001236 183.0
HKD2_k127_8083983_13 TIGRFAM PAS sensor protein - - - 0.00000000000000000000000000000000000000000000000361 183.0
HKD2_k127_8083983_14 Protein of unknown function (DUF2946) - - - 0.0000000000000000000000000000000000000000824 158.0
HKD2_k127_8083983_15 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000000000806 89.0
HKD2_k127_8083983_16 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000001117 76.0
HKD2_k127_8083983_2 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008507 428.0
HKD2_k127_8083983_3 Periplasmic binding protein domain K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009746 388.0
HKD2_k127_8083983_4 Branched-chain amino acid transport system / permease component K01998 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006345 394.0
HKD2_k127_8083983_5 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002408 368.0
HKD2_k127_8083983_6 Endonuclease Exonuclease phosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004615 321.0
HKD2_k127_8083983_7 Branched-chain amino acid transport system / permease component K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001136 286.0
HKD2_k127_8083983_8 ABC transporter K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001569 269.0
HKD2_k127_8083983_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000702 255.0
HKD2_k127_8117168_0 Helicase associated domain (HA2) Add an annotation K03578 - 3.6.4.13 0.0 1395.0
HKD2_k127_8117168_1 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006992 426.0
HKD2_k127_8117168_10 Etoposide-induced protein 2.4 (EI24) - - - 0.0000000000000000000000000000000000000004165 161.0
HKD2_k127_8117168_11 Thioredoxin K00384,K03671,K03672 - 1.8.1.8,1.8.1.9 0.00000000000000000000007774 99.0
HKD2_k127_8117168_2 amino acid K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004812 352.0
HKD2_k127_8117168_3 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 346.0
HKD2_k127_8117168_4 ATPases associated with a variety of cellular activities - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007192 334.0
HKD2_k127_8117168_5 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 299.0
HKD2_k127_8117168_6 molybdopterin binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001827 284.0
HKD2_k127_8117168_7 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004992 279.0
HKD2_k127_8117168_8 Phasin protein - - - 0.000000000000000000000000000000000000000000000000004169 188.0
HKD2_k127_8117168_9 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000002616 183.0
HKD2_k127_843330_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1119.0
HKD2_k127_843330_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 495.0
HKD2_k127_843330_2 Belongs to the peptidase S11 family K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 454.0
HKD2_k127_843330_3 PFAM Aminotransferase, class IV K00824 - 2.6.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003736 368.0
HKD2_k127_843330_4 Protein of unknown function (DUF4197) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005909 268.0
HKD2_k127_843330_5 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.0000000000000000000000000000000000000000000000000000000000000000000543 242.0
HKD2_k127_843330_6 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000002377 127.0
HKD2_k127_843330_7 Belongs to the UPF0250 family K09158 - - 0.000000000000000000000000003002 118.0
HKD2_k127_843330_8 Protein of unknown function (DUF1161) - - - 0.00000000000000000002101 93.0
HKD2_k127_8461470_0 Pyruvate ferredoxin/flavodoxin oxidoreductase K04090 - 1.2.7.8 2.922e-194 618.0
HKD2_k127_8461470_1 Cytochrome P450 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001419 509.0
HKD2_k127_8461470_2 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004952 385.0
HKD2_k127_8461470_3 Outer membrane usher protein K07347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007934 396.0
HKD2_k127_8461470_4 Carboxymuconolactone decarboxylase family - - - 0.0000000000000000000000000000000000000000000002408 173.0
HKD2_k127_8461470_5 pilus organization K07346 - - 0.000000000000000000000000000000000001553 149.0
HKD2_k127_8461470_6 response regulator - - - 0.000000001952 66.0
HKD2_k127_8461470_7 Spore Coat Protein U domain - - - 0.00004961 52.0
HKD2_k127_8463827_0 Bifunctional transglycosylase second domain K05365 - 2.4.1.129,3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001365 428.0
HKD2_k127_8463827_1 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007467 377.0
HKD2_k127_8463827_10 Iron-binding zinc finger CDGSH type K05710 - - 0.000000000000000008087 87.0
HKD2_k127_8463827_2 Periplasmic binding protein domain K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009662 374.0
HKD2_k127_8463827_3 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002281 299.0
HKD2_k127_8463827_4 ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001602 291.0
HKD2_k127_8463827_5 Belongs to the binding-protein-dependent transport system permease family K01997,K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004882 287.0
HKD2_k127_8463827_6 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000441 285.0
HKD2_k127_8463827_7 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001308 228.0
HKD2_k127_8463827_8 Calcineurin-like phosphoesterase superfamily domain - - - 0.0000000000000000000000000000000000004987 151.0
HKD2_k127_8463827_9 Tetratricopeptide repeat - - - 0.0000000000000000000000002831 110.0
HKD2_k127_8520166_0 Competence protein ComEC Rec2 K02238 - - 5.77e-213 685.0
HKD2_k127_8520166_1 the major facilitator superfamily K03446 - - 1.016e-196 644.0
HKD2_k127_8520166_10 Uncharacterized protein conserved in bacteria (DUF2062) K09928 - - 0.0000000000000000000000000000000000000000000000005407 185.0
HKD2_k127_8520166_11 Glutathione-dependent formaldehyde-activating - - - 0.000000000000000000000000000000000000000007007 158.0
HKD2_k127_8520166_12 Belongs to the GST superfamily K00799 - 2.5.1.18 0.0000000000000000000000000000000000001939 148.0
HKD2_k127_8520166_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000009322 130.0
HKD2_k127_8520166_2 TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000361 534.0
HKD2_k127_8520166_3 Aminotransferase class I and II K09758 - 4.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 492.0
HKD2_k127_8520166_4 AMP-binding enzyme C-terminal domain K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 457.0
HKD2_k127_8520166_5 Biotin-lipoyl like K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004362 417.0
HKD2_k127_8520166_6 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 366.0
HKD2_k127_8520166_7 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002459 295.0
HKD2_k127_8520166_8 Part of the ABC transporter complex LolCDE involved in the translocation of K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005225 285.0
HKD2_k127_8520166_9 Haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000008612 225.0
HKD2_k127_8524029_0 Glutamine synthetase, catalytic domain K01915,K20712 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 4.485e-250 782.0
HKD2_k127_8524029_1 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 426.0
HKD2_k127_8524029_2 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 347.0
HKD2_k127_8524029_3 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000000000000000000000006385 196.0
HKD2_k127_8524029_4 Serine aminopeptidase, S33 K06889 - - 0.00000000000000000000000000000000000000000000000000001628 200.0
HKD2_k127_8524029_5 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000000000000000000000614 139.0
HKD2_k127_8643250_0 FAD linked oxidase domain protein K06911 - - 0.0 1212.0
HKD2_k127_8643250_1 peptidase U62, modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009328 552.0
HKD2_k127_8643250_10 Peptidase family M48 - - - 0.00000000000000000000000000000969 130.0
HKD2_k127_8643250_11 DSBA-like thioredoxin domain - - - 0.000000000000000000000001183 118.0
HKD2_k127_8643250_12 Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) K06622 GO:0000079,GO:0000082,GO:0000278,GO:0001558,GO:0001932,GO:0001933,GO:0003674,GO:0004857,GO:0004860,GO:0004861,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006469,GO:0007049,GO:0007050,GO:0007346,GO:0008150,GO:0008285,GO:0009892,GO:0009987,GO:0010563,GO:0010564,GO:0010605,GO:0016538,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0022402,GO:0030234,GO:0030291,GO:0030308,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031657,GO:0031658,GO:0032268,GO:0032269,GO:0033673,GO:0040008,GO:0042127,GO:0042325,GO:0042326,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043549,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0045736,GO:0045786,GO:0045859,GO:0045926,GO:0045936,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051128,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0051726,GO:0060255,GO:0065007,GO:0065009,GO:0071900,GO:0071901,GO:0080090,GO:0098772,GO:1901987,GO:1901990,GO:1902806,GO:1903047,GO:1904029,GO:1904030,GO:2000045 - 0.0000000000001899 79.0
HKD2_k127_8643250_2 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 427.0
HKD2_k127_8643250_3 luciferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002383 361.0
HKD2_k127_8643250_4 Molybdenum cofactor biosynthesis protein K03831 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 312.0
HKD2_k127_8643250_5 serine threonine protein kinase K11912,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000002073 236.0
HKD2_k127_8643250_6 Protein of unknown function (DUF3237) - - - 0.00000000000000000000000000000000000000000000000002976 190.0
HKD2_k127_8643250_7 Bacterial PH domain - - - 0.0000000000000000000000000000000000000000000001917 171.0
HKD2_k127_8643250_8 Cupin domain - - - 0.000000000000000000000000000000000000000000002179 170.0
HKD2_k127_8643250_9 Belongs to the UPF0307 family K09889 - - 0.0000000000000000000000000000000000000003812 156.0
HKD2_k127_8850802_0 AMP-binding enzyme K12508 - 6.2.1.34 1.083e-218 705.0
HKD2_k127_8850802_1 Rhodanese Homology Domain - - - 2.103e-196 635.0
HKD2_k127_8850802_2 Receptor family ligand binding region K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 605.0
HKD2_k127_8850802_3 PFAM L-carnitine dehydratase bile acid-inducible protein F - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001251 494.0
HKD2_k127_8850802_4 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 417.0
HKD2_k127_8850802_5 cysteine dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000936 264.0
HKD2_k127_8850802_6 SelR domain K07305,K12267 - 1.8.4.11,1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000344 213.0
HKD2_k127_8850802_7 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000001369 209.0
HKD2_k127_8850802_8 - - - - 0.000000000000000000000000000000000000000000006833 174.0
HKD2_k127_8850802_9 Histidine kinase-like ATPase domain - - - 0.00000000000000000000001032 111.0
HKD2_k127_8942889_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 1.42e-283 884.0
HKD2_k127_8942889_1 PFAM ABC transporter K06158 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 576.0
HKD2_k127_8942889_10 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate K03271 - 5.3.1.28 0.00000000000000000000000000000000000000000000000000000000000000000000000004346 255.0
HKD2_k127_8942889_11 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose K21345 - 2.7.7.70 0.0000000000000000000000000000000000000000000000000000000000000000000003096 243.0
HKD2_k127_8942889_12 glycosyl transferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000004749 243.0
HKD2_k127_8942889_13 Protein of unknown function (DUF3025) - - - 0.00000000000000000000000000000000000000000000000000002587 205.0
HKD2_k127_8942889_14 PFAM transport-associated - - - 0.00000000000000000000000000000000000000000000000000008247 201.0
HKD2_k127_8942889_15 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000000000391 128.0
HKD2_k127_8942889_16 - - - - 0.000000000000000000000000162 112.0
HKD2_k127_8942889_17 diguanylate cyclase - - - 0.0000000009086 66.0
HKD2_k127_8942889_2 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009459 551.0
HKD2_k127_8942889_3 Amidase K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 544.0
HKD2_k127_8942889_4 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002162 508.0
HKD2_k127_8942889_5 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 320.0
HKD2_k127_8942889_6 Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007854 290.0
HKD2_k127_8942889_7 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002872 275.0
HKD2_k127_8942889_8 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007973 272.0
HKD2_k127_8942889_9 Belongs to the DEAD box helicase family K11927 - 3.6.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000002643 264.0
HKD2_k127_9005101_0 Belongs to the TPP enzyme family K01652 - 2.2.1.6 1.608e-319 985.0
HKD2_k127_9005101_1 FAD dependent oxidoreductase - - - 1.471e-250 780.0
HKD2_k127_9005101_2 Benzoate membrane transport protein K05782 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002814 502.0
HKD2_k127_9005101_3 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 323.0
HKD2_k127_9005101_4 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 311.0
HKD2_k127_9005101_5 short-chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000002287 216.0
HKD2_k127_9005101_6 Cupin - - - 0.000000000000000000000000000000000000000000001693 171.0
HKD2_k127_9005101_7 Glutathione S-transferase K00799 - 2.5.1.18 0.0000004619 61.0
HKD2_k127_9028950_0 E1 component K00164 - 1.2.4.2 0.0 1322.0
HKD2_k127_9028950_1 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 - 1.3.5.1,1.3.5.4 6.14e-252 787.0
HKD2_k127_9028950_10 Flavinator of succinate dehydrogenase K09159 - - 0.000000000000004912 77.0
HKD2_k127_9028950_2 Belongs to the citrate synthase family K01647 - 2.3.3.1 4.254e-234 730.0
HKD2_k127_9028950_3 Dehydrogenase K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 3.32e-206 650.0
HKD2_k127_9028950_4 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005455 561.0
HKD2_k127_9028950_5 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 432.0
HKD2_k127_9028950_6 PFAM AFG1-family ATPase K06916 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 419.0
HKD2_k127_9028950_7 COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases K00001 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007551 402.0
HKD2_k127_9028950_8 PspC domain - - - 0.000000000000000000000000000001802 123.0
HKD2_k127_9028950_9 - - - - 0.0000000000000001449 83.0
HKD2_k127_9036742_0 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB K02454,K02652 - - 1.037e-240 755.0
HKD2_k127_9036742_1 Type II and III secretion system protein K02453 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001192 507.0
HKD2_k127_9036742_10 - - - - 0.00000000000104 79.0
HKD2_k127_9036742_2 type II secretion system protein K02653 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004525 487.0
HKD2_k127_9036742_3 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001107 400.0
HKD2_k127_9036742_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002313 263.0
HKD2_k127_9036742_5 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000009109 199.0
HKD2_k127_9036742_6 RESPONSE REGULATOR receiver K07712 - - 0.000000000000000000000000000000000000000001617 160.0
HKD2_k127_9036742_7 general secretion pathway protein - - - 0.0000000000000000000000000000000008937 148.0
HKD2_k127_9036742_8 Prokaryotic N-terminal methylation motif - - - 0.000000000000000000000000002994 120.0
HKD2_k127_9036742_9 - - - - 0.0000000000000000002864 96.0
HKD2_k127_9047556_0 Belongs to the thiolase family K00626 - 2.3.1.9 2.244e-204 642.0
HKD2_k127_9047556_1 von Willebrand factor, type A K07114 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007377 592.0
HKD2_k127_9047556_2 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 535.0
HKD2_k127_9047556_3 Sortase family K07284 - 3.4.22.70 0.00000000000000000000000000000000000000000001004 182.0
HKD2_k127_9053080_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 7.872e-242 754.0
HKD2_k127_9053080_1 Belongs to the IlvD Edd family K01687 GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 1.501e-224 709.0
HKD2_k127_9053080_10 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007946 317.0
HKD2_k127_9053080_11 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 - 1.1.1.31,1.1.1.60 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 315.0
HKD2_k127_9053080_12 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001474 267.0
HKD2_k127_9053080_13 PFAM HhH-GPD family protein K01247 - 3.2.2.21 0.000000000000000000000000000000000000000000000000000000000000000000000000001925 259.0
HKD2_k127_9053080_14 COG0477 Permeases of the major facilitator superfamily K05820 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006727 261.0
HKD2_k127_9053080_15 type 4 pilus biogenesis protein K02656 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002338 247.0
HKD2_k127_9053080_16 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000000001509 238.0
HKD2_k127_9053080_17 Tetratricopeptide repeat-like domain - - - 0.0000000000000000000000000000000000000000000000000000007705 199.0
HKD2_k127_9053080_18 Iron permease FTR1 family K07243 - - 0.0000000000000000000000000000000000000000008985 161.0
HKD2_k127_9053080_19 Helix-turn-helix domain K15539 - - 0.00000000000000000000000000000000000000009371 163.0
HKD2_k127_9053080_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000331 616.0
HKD2_k127_9053080_20 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000001759 131.0
HKD2_k127_9053080_21 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.0000000000000000000001307 104.0
HKD2_k127_9053080_22 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006323,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010556,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051276,GO:0060255,GO:0065007,GO:0071103,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2001141 - 0.000000000000000000002207 96.0
HKD2_k127_9053080_3 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008154 550.0
HKD2_k127_9053080_4 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001085 546.0
HKD2_k127_9053080_5 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003594 532.0
HKD2_k127_9053080_6 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 527.0
HKD2_k127_9053080_7 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 516.0
HKD2_k127_9053080_8 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005872 357.0
HKD2_k127_9053080_9 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008421 340.0
HKD2_k127_9119425_0 ribonuclease, Rne Rng family K08301 - - 3.17e-233 730.0
HKD2_k127_9119425_1 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002899 483.0
HKD2_k127_9119425_2 Belongs to the amidase family K01426,K02433 - 3.5.1.4,6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003115 357.0
HKD2_k127_9119425_3 Maf-like protein K06287 - - 0.000000000000000000000000000000000000000000000000000000000000002525 227.0
HKD2_k127_9119425_4 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969 - 2.7.7.18 0.000000000000000000000000000000000000000000000001704 179.0
HKD2_k127_9119425_5 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.0000000000000000000000000000000000000000004783 162.0
HKD2_k127_9119425_6 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000000000000000000000009004 158.0
HKD2_k127_9138334_0 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 1.067e-254 792.0
HKD2_k127_9138334_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001149 429.0
HKD2_k127_9138334_2 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005206 431.0
HKD2_k127_9138334_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000000000000000001257 169.0
HKD2_k127_9138334_4 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.0000000000000000000001176 98.0
HKD2_k127_9168177_0 Phosphoesterase family - - - 1.913e-200 636.0
HKD2_k127_9168177_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004683 417.0
HKD2_k127_9168177_2 Belongs to the D-glutamate cyclase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 366.0
HKD2_k127_9168177_3 Predicted integral membrane protein (DUF2189) - - - 0.0000000000000000000000000000000000000000000000000000000005602 223.0
HKD2_k127_9168177_4 NUDIX domain - - - 0.0000000000000000000000000000000000000000000009403 170.0
HKD2_k127_9168177_5 Belongs to the small heat shock protein (HSP20) family - - - 0.0000000000000000000000000000000000001373 148.0
HKD2_k127_9169600_0 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001668 627.0
HKD2_k127_9169600_1 PFAM Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 516.0
HKD2_k127_9169600_10 - - - - 0.00000000000000000000000000999 115.0
HKD2_k127_9169600_2 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009352 420.0
HKD2_k127_9169600_3 aldo keto reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005641 421.0
HKD2_k127_9169600_4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005205 398.0
HKD2_k127_9169600_5 Histone deacetylase domain K04768 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000729 364.0
HKD2_k127_9169600_6 squalene-associated FAD-dependent desaturase K21677 - 1.17.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001885 271.0
HKD2_k127_9169600_7 GMP synthase (glutamine-hydrolyzing) activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008595 246.0
HKD2_k127_9169600_8 ABC-type transport system involved in resistance to organic solvents, auxiliary component K07323 - - 0.0000000000000000000000000000000000000002251 171.0
HKD2_k127_9169600_9 - - - - 0.0000000000000000000000000001352 119.0
HKD2_k127_917399_0 AMP-binding enzyme C-terminal domain K00666 - - 6.043e-240 755.0
HKD2_k127_917399_1 CoA binding domain K09181 - - 1.112e-194 649.0
HKD2_k127_917399_2 PFAM MmgE PrpD family protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004119 528.0
HKD2_k127_917399_3 acyl-CoA transferases carnitine dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 407.0
HKD2_k127_917399_4 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K01714 - 4.3.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000873 348.0
HKD2_k127_917399_5 Protein of unknown function (DUF1847) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009937 319.0
HKD2_k127_917399_6 Haem-degrading - - - 0.00000000000000000000000000000000000000000000000000000000000003293 228.0
HKD2_k127_917399_7 Domain of Unknown Function (DUF748) - - - 0.0000000000000000000000000000000000003131 147.0
HKD2_k127_917399_8 Belongs to the mandelate racemase muconate lactonizing enzyme family K01684 - 4.2.1.6 0.0000000001592 74.0
HKD2_k127_9175430_0 Glucose / Sorbosone dehydrogenase - - - 1.245e-205 647.0
HKD2_k127_9175430_1 FAD binding domain K00480,K22270 - 1.14.13.1,1.14.13.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004183 479.0
HKD2_k127_9175430_2 COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 414.0
HKD2_k127_9175430_3 Cytochrome c K17230 - - 0.000000000000000000000000000000000000000000000000000000003299 205.0
HKD2_k127_9175430_4 PFAM FMN-dependent alpha-hydroxy acid dehydrogenase K00101,K15054 - 1.1.2.3,1.1.99.31 0.00000000000000000000000000000000000000000002985 165.0
HKD2_k127_9175430_5 Ring hydroxylating subunit beta family protein 1 - - - 0.00000000000000000000000000000004938 132.0
HKD2_k127_9175430_6 Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria - - - 0.00000000000000000001675 94.0
HKD2_k127_9175430_7 Sugar-specific transcriptional regulator TrmB - - - 0.0000000000005724 75.0
HKD2_k127_9175430_8 Branched-chain amino acid transport system / permease component K01997 - - 0.0000005539 52.0
HKD2_k127_9205081_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 0.0 1242.0
HKD2_k127_9205081_1 PFAM peptidase M3A and M3B thimet oligopeptidase F K01414 - 3.4.24.70 1.123e-309 971.0
HKD2_k127_9205081_2 TIGRFAM malate synthase A K01638 - 2.3.3.9 3.107e-250 781.0
HKD2_k127_9205081_3 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 486.0
HKD2_k127_9205081_4 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003938 410.0
HKD2_k127_9205081_5 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 386.0
HKD2_k127_9205081_6 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003602 361.0
HKD2_k127_9205081_7 Sigma-54 interaction domain protein K07712,K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 288.0
HKD2_k127_9205081_8 Domain of unknown function (DUF4124) - - - 0.000000000000000000000000469 113.0
HKD2_k127_9299986_0 Fumarate reductase flavoprotein C-term - - - 2.26e-220 697.0
HKD2_k127_9299986_1 FAD binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 614.0
HKD2_k127_9299986_2 Dihydrodipicolinate synthetase family K01714 - 4.3.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001431 421.0
HKD2_k127_9299986_3 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001908 374.0
HKD2_k127_9299986_4 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000002657 177.0
HKD2_k127_9299986_5 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000003079 152.0
HKD2_k127_9323383_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1224.0
HKD2_k127_9323383_1 DNA helicase K03657 - 3.6.4.12 4.723e-297 927.0
HKD2_k127_9323383_10 Soluble lytic murein transglycosylase L domain K08309 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001287 276.0
HKD2_k127_9323383_11 Belongs to the GST superfamily K11209 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007599 273.0
HKD2_k127_9323383_12 protein involved in response to NO - - - 0.00000000000000000000000000000000000000000000000000000000000000009258 241.0
HKD2_k127_9323383_13 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000000000000000000000003456 224.0
HKD2_k127_9323383_14 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - 0.000000000000000000000000000000000000000000000002156 181.0
HKD2_k127_9323383_15 Thioredoxin domain - - - 0.000000000000000000000000000000000000000000002334 178.0
HKD2_k127_9323383_16 transcriptional regulator K13771 - - 0.000000000000000000000000000000000000000000005856 167.0
HKD2_k127_9323383_17 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 - 1.2.1.41 0.00000000000000000000000000000000000000000003915 164.0
HKD2_k127_9323383_18 - - - - 0.0000000000000000000000000000000000000000007738 164.0
HKD2_k127_9323383_19 - - - - 0.000000000000000000000000000000000000000002122 160.0
HKD2_k127_9323383_2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835 - 5.4.2.2 3.244e-247 773.0
HKD2_k127_9323383_20 membrane - - - 0.00000000000000000000000000000000006899 137.0
HKD2_k127_9323383_21 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.000000000000000000000000000001144 138.0
HKD2_k127_9323383_22 Uncharacterized conserved protein (DUF2249) - - - 0.0000000000000000000000000002513 129.0
HKD2_k127_9323383_23 Belongs to the HesB IscA family K13628 - - 0.00000000000000000000000000272 122.0
HKD2_k127_9323383_24 Cobalt uptake substrate-specific transmembrane region - - - 0.000000000000000000000009891 111.0
HKD2_k127_9323383_25 Protein of unknown function (DUF2905) - - - 0.000000000005396 69.0
HKD2_k127_9323383_3 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 4.125e-235 737.0
HKD2_k127_9323383_4 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003373 370.0
HKD2_k127_9323383_5 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 354.0
HKD2_k127_9323383_6 epimerase dehydratase K00329,K00356 - 1.6.5.3,1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004939 320.0
HKD2_k127_9323383_7 Soluble lytic murein transglycosylase L domain K08309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009135 296.0
HKD2_k127_9323383_8 Phytanoyl-CoA dioxygenase (PhyH) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000009644 277.0
HKD2_k127_9323383_9 Glutathione S-transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001251 277.0
HKD2_k127_9324917_0 UvrD-like helicase C-terminal domain K03657 - 3.6.4.12 1.268e-230 734.0
HKD2_k127_9324917_1 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family K00111 - 1.1.5.3 4.739e-201 642.0
HKD2_k127_9324917_10 Cytochrome c - - - 0.0000000000000000000000000000000003968 137.0
HKD2_k127_9324917_11 acetyltransferase - - - 0.00000000000000000000000000002403 128.0
HKD2_k127_9324917_12 Major Facilitator Superfamily - - - 0.00000000000000000000000006286 111.0
HKD2_k127_9324917_13 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.0000000000000000000000001166 113.0
HKD2_k127_9324917_14 SPW repeat - - - 0.000000000000000000001226 97.0
HKD2_k127_9324917_15 N-terminal half of MaoC dehydratase K09709 - 4.2.1.153 0.00007828 46.0
HKD2_k127_9324917_2 Predicted membrane protein (DUF2207) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008784 403.0
HKD2_k127_9324917_3 Acyl-CoA dehydrogenase, C-terminal domain K16047 - 1.14.14.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001809 357.0
HKD2_k127_9324917_4 N-terminal half of MaoC dehydratase K09709,K18291 - 4.2.1.153,4.2.1.56 0.000000000000000000000000000000000000000000000000000000000000007006 223.0
HKD2_k127_9324917_5 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000000000000000001188 186.0
HKD2_k127_9324917_6 LemA family - - - 0.000000000000000000000000000000000000000000000152 173.0
HKD2_k127_9324917_7 Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000009117 180.0
HKD2_k127_9324917_8 Protein of unknown function, DUF - - - 0.0000000000000000000000000000000000000102 151.0
HKD2_k127_9324917_9 Nuclease-related domain - - - 0.00000000000000000000000000000000000007102 153.0
HKD2_k127_9548414_0 4Fe-4S dicluster domain - - - 0.0 1218.0
HKD2_k127_9548414_1 Belongs to the IlvD Edd family - - - 3.981e-271 843.0
HKD2_k127_9548414_2 PFAM AMP-dependent synthetase and ligase - - - 1.679e-229 720.0
HKD2_k127_9548414_3 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase K00830 - 2.6.1.44,2.6.1.45,2.6.1.51 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 592.0
HKD2_k127_9548414_4 CoA-transferase family III K07749 - 2.8.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 462.0
HKD2_k127_9548414_5 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 380.0
HKD2_k127_9548414_6 FCD - - - 0.00000000000000000000000000000000000000000000000000000000000000001128 246.0
HKD2_k127_9548414_7 NADH:flavin oxidoreductase / NADH oxidase family - - - 0.00000000000000000000000000000000000000000001717 164.0
HKD2_k127_9557901_0 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K18661 - - 3.652e-202 640.0
HKD2_k127_9557901_1 Histidine kinase K07641 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 377.0
HKD2_k127_9557901_2 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006846 323.0
HKD2_k127_9557901_3 membrane transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006427 288.0
HKD2_k127_9557901_4 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483,K07663 GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.00000000000000000000000000000000000000000000000000000000000003777 216.0
HKD2_k127_9557901_5 Enoyl-CoA hydratase - - - 0.0000000000000000000000000000000000000000000000000000008214 202.0
HKD2_k127_9557901_6 L-carnitine dehydratase bile acid-inducible protein F - - - 0.00000000000000000000000000000000000001578 147.0
HKD2_k127_9557901_7 Histidine kinase K07641 - 2.7.13.3 0.000000007611 68.0
HKD2_k127_9571414_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 1.724e-258 801.0
HKD2_k127_9571414_1 Bacterial transcriptional activator domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005209 520.0
HKD2_k127_9571414_2 Methylenetetrahydrofolate reductase K00297 GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 428.0
HKD2_k127_9571414_3 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006312 286.0
HKD2_k127_9571414_4 ZIP Zinc transporter K07238 - - 0.000000000000000000000000001374 115.0
HKD2_k127_9571414_5 - - - - 0.00000000000000000000001763 105.0
HKD2_k127_9571414_6 Sel1-like repeats. K07126 - - 0.0000002007 55.0
HKD2_k127_9611546_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 2.731e-291 914.0
HKD2_k127_9611546_1 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003285 577.0
HKD2_k127_9611546_10 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002791 256.0
HKD2_k127_9611546_11 Lysin motif K06194 - - 0.0000000000000000000000000000000000000000000000000000000000000000008233 240.0
HKD2_k127_9611546_12 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000000000000000408 189.0
HKD2_k127_9611546_13 PFAM regulatory protein MerR - - - 0.00000000000000000000000000000000000000000000000003471 181.0
HKD2_k127_9611546_14 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.00000000000000000000000000000000000000000000004812 171.0
HKD2_k127_9611546_15 Ribosomal protein L35 K02916 - - 0.0000000000000000006041 87.0
HKD2_k127_9611546_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 557.0
HKD2_k127_9611546_3 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000623 530.0
HKD2_k127_9611546_4 Glutathione S-transferase, C-terminal domain K07393 - 1.8.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002006 492.0
HKD2_k127_9611546_5 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 370.0
HKD2_k127_9611546_6 Transglycosylase SLT domain K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008492 310.0
HKD2_k127_9611546_7 Glutathione S-transferase, C-terminal domain K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008969 278.0
HKD2_k127_9611546_8 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000000000000000000000000000000000000000000000000000000000000000000000000013 276.0
HKD2_k127_9611546_9 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005542 261.0
HKD2_k127_9658566_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 4.686e-230 717.0
HKD2_k127_9658566_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 542.0
HKD2_k127_9658566_10 50S ribosomal protein L4 K02926 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007271 292.0
HKD2_k127_9658566_11 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 282.0
HKD2_k127_9658566_12 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004464 276.0
HKD2_k127_9658566_13 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003769 264.0
HKD2_k127_9658566_14 Transglutaminase-like superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001284 256.0
HKD2_k127_9658566_15 Ribosomal protein L16p/L10e K02878 - - 0.0000000000000000000000000000000000000000000000000000000000000000000007113 238.0
HKD2_k127_9658566_16 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000000005462 233.0
HKD2_k127_9658566_17 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.00000000000000000000000000000000000000000000000000000000000000003942 223.0
HKD2_k127_9658566_18 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000000000003419 217.0
HKD2_k127_9658566_19 Ribosomal protein L17 K02879 - - 0.00000000000000000000000000000000000000000000000000000000001654 208.0
HKD2_k127_9658566_2 Domain of unknown function (DUF4147) K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003318 557.0
HKD2_k127_9658566_20 binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000000000007074 197.0
HKD2_k127_9658566_21 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000000001786 191.0
HKD2_k127_9658566_22 Involved in the binding of tRNA to the ribosomes K02946 - - 0.00000000000000000000000000000000000000000000000000003078 190.0
HKD2_k127_9658566_23 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.0000000000000000000000000000000000000000000000000001413 186.0
HKD2_k127_9658566_24 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000000000000000000000000002913 184.0
HKD2_k127_9658566_25 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000001351 166.0
HKD2_k127_9658566_26 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.00000000000000000000000000000000000002369 145.0
HKD2_k127_9658566_27 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000005833 145.0
HKD2_k127_9658566_28 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.00000000000000000000000000000000000008543 143.0
HKD2_k127_9658566_29 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.0000000000000000000000000000000002198 144.0
HKD2_k127_9658566_3 Gentisate 1,2-dioxygenase K00450 - 1.13.11.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001491 469.0
HKD2_k127_9658566_30 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.00000000000000000000000000000006184 129.0
HKD2_k127_9658566_31 Belongs to the universal ribosomal protein uL29 family K02904 - - 0.0000000000000000003111 88.0
HKD2_k127_9658566_32 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000008526 82.0
HKD2_k127_9658566_33 Ribosomal protein L30 K02907 - - 0.0000000000000004117 87.0
HKD2_k127_9658566_34 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000003032 71.0
HKD2_k127_9658566_4 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 455.0
HKD2_k127_9658566_5 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005734 348.0
HKD2_k127_9658566_6 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003224 331.0
HKD2_k127_9658566_7 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007965 315.0
HKD2_k127_9658566_8 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000252 299.0
HKD2_k127_9658566_9 alpha/beta hydrolase fold K01432 - 3.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 299.0
HKD2_k127_9692592_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1697.0
HKD2_k127_9692592_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.0 1068.0
HKD2_k127_9692592_10 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003615 324.0
HKD2_k127_9692592_11 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000425 328.0
HKD2_k127_9692592_12 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02194 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000008208 271.0
HKD2_k127_9692592_13 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009002 253.0
HKD2_k127_9692592_14 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.0000000000000000000000000000000000000000000000000000000001251 217.0
HKD2_k127_9692592_15 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K21563 - - 0.0000000000000000000000000000000000000000000000000000000003021 213.0
HKD2_k127_9692592_16 NapC/NirT cytochrome c family, N-terminal region K02569 - - 0.000000000000000000000000000000000000000000000000000000000323 209.0
HKD2_k127_9692592_17 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.00000000000000000000000000000000000000000000000000000001405 204.0
HKD2_k127_9692592_18 Cytochrome c K08738 - - 0.0000000000000000000000000000007836 125.0
HKD2_k127_9692592_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002617 622.0
HKD2_k127_9692592_3 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008055 561.0
HKD2_k127_9692592_4 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008664 481.0
HKD2_k127_9692592_5 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 434.0
HKD2_k127_9692592_6 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 427.0
HKD2_k127_9692592_7 phosphate transport system permease K02038 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 420.0
HKD2_k127_9692592_8 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes K02195 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000438 377.0
HKD2_k127_9692592_9 TIGRFAM decaheme c-type cytochrome, DmsE family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007284 332.0
HKD2_k127_9827177_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 1.082e-296 926.0
HKD2_k127_9827177_1 NADH ubiquinone plastoquinone (Complex I) - - - 4.043e-273 855.0
HKD2_k127_9827177_10 Type IV pilus biogenesis stability protein PilW - - - 0.00000000000000000000000000001724 124.0
HKD2_k127_9827177_2 Belongs to the Orn Lys Arg decarboxylase class-II family K01581 - 4.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 575.0
HKD2_k127_9827177_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 559.0
HKD2_k127_9827177_4 NADH dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002979 466.0
HKD2_k127_9827177_5 NADH Ubiquinone plastoquinone (Complex I) K12141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009295 413.0
HKD2_k127_9827177_6 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 371.0
HKD2_k127_9827177_7 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005139 354.0
HKD2_k127_9827177_8 hydrogenase 4 membrane K12140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006632 305.0
HKD2_k127_9827177_9 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001666 276.0
HKD2_k127_98383_0 Flavin containing amine oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 552.0
HKD2_k127_98383_1 Mycolic acid cyclopropane synthetase K00574 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 416.0
HKD2_k127_98383_2 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003591 347.0
HKD2_k127_98383_3 Protein of unknown function (DUF1365) K09701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005931 332.0
HKD2_k127_98383_4 Protein of unknown function (DUF3833) - - - 0.000000000000000000000000000000000000000000000000000000000002055 222.0
HKD2_k127_98383_5 B12 binding domain K22491 - - 0.000000000000000000000000000000000000000003603 160.0
HKD2_k127_98383_6 Chalcone isomerase-like - - - 0.000000000000000000000000000000000003755 147.0
HKD2_k127_98383_7 Dehydrogenase - - - 0.000000000000000003485 94.0
HKD2_k127_9875239_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 1.376e-282 885.0
HKD2_k127_9875239_1 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 344.0
HKD2_k127_9875239_2 Major Facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003628 244.0
HKD2_k127_9936938_0 AMP-binding enzyme C-terminal domain K00666,K20034 - 6.2.1.44 1.347e-265 826.0
HKD2_k127_9936938_1 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 522.0
HKD2_k127_9936938_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003595 447.0
HKD2_k127_9936938_3 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 433.0
HKD2_k127_9936938_4 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002452 385.0
HKD2_k127_9936938_5 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001588 359.0
HKD2_k127_9936938_6 ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 362.0
HKD2_k127_9936938_7 enoyl-CoA hydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001048 271.0
HKD2_k127_9936938_8 Cell wall hydrolase autolysin K01448 - 3.5.1.28 0.00000000000000000000000000000000000000000000005699 181.0
HKD2_k127_9938284_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 3.597e-234 742.0
HKD2_k127_9938284_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 5.612e-232 740.0
HKD2_k127_9938284_2 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001158 351.0
HKD2_k127_9938284_3 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 298.0
HKD2_k127_9938284_4 Protein of unknown function DUF99 K09120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000197 261.0
HKD2_k127_9938284_5 Dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000005948 208.0
HKD2_k127_9938284_6 Protein of unknown function (DUF1499) - - - 0.0000000000000000000000000000000000000000000000155 180.0
HKD2_k127_9938284_7 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000402 143.0