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Overview

ID MAG01800
Name HKD2_bin.48
Sample SMP0047
Taxonomy
Kingdom Archaea
Phylum Thermoplasmatota
Class E2
Order DHVEG-1
Family DHVEG-1
Genus SM1-50
Species
Assembly information
Completeness (%) 76.71
Contamination (%) 0.61
GC content (%) 46.0
N50 (bp) 4,021
Genome size (bp) 1,373,831

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes1310

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10013166_0 - - - - 0.000000000000117 84.0
HKD2_k127_10013166_1 PFAM Cold-shock protein, DNA-binding K03704 - - 0.00000000004947 66.0
HKD2_k127_10013166_2 Winged helix-turn-helix domain (DUF2582) - - - 0.000006514 53.0
HKD2_k127_10013166_3 Winged helix-turn-helix domain (DUF2582) - - - 0.0009721 46.0
HKD2_k127_10055358_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03044,K13798 - 2.7.7.6 0.0 1166.0
HKD2_k127_10055358_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03041 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005401 527.0
HKD2_k127_10055358_2 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03053 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000002184 102.0
HKD2_k127_10109014_0 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000000000000132 231.0
HKD2_k127_10109014_1 DNA polymerase Ligase (LigD) - - - 0.00000000000000000000000000000000000000000000000001173 184.0
HKD2_k127_10109014_2 Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen K10979 GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363 - 0.000000000000000000000000000000000000000000000001248 183.0
HKD2_k127_10109014_3 DNA ligase K01971,K10747 - 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000008003 183.0
HKD2_k127_10109014_4 homolog of PrgY (pheromone shutdown protein) - - - 0.000000000000000000000000000000000002989 147.0
HKD2_k127_10109014_5 protein kinase related protein - - - 0.0000000000000000000000006821 120.0
HKD2_k127_10109014_6 Domain of unknown function (DUF4382) - - - 0.00002221 51.0
HKD2_k127_10109876_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 1.953e-210 675.0
HKD2_k127_10109876_1 Psort location Cytoplasmic, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001927 558.0
HKD2_k127_10109876_2 heterodisulfide reductase, subunit K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000001872 212.0
HKD2_k127_10109989_0 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues K01299 - 3.4.17.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 409.0
HKD2_k127_10109989_1 PFAM Endonuclease Exonuclease phosphatase K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 365.0
HKD2_k127_10109989_2 TIGRFAM ribosomal RNA small subunit methyltransferase RsmB K03500 - 2.1.1.176 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003987 360.0
HKD2_k127_10109989_3 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001072 290.0
HKD2_k127_10109989_4 ABC-2 family transporter protein K01992 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003178 272.0
HKD2_k127_10109989_5 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K01834 GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000698 258.0
HKD2_k127_10109989_6 RHS Repeat - - - 0.0007815 52.0
HKD2_k127_10128142_0 Glycine cleavage system P-protein K00282 - 1.4.4.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003875 345.0
HKD2_k127_10130950_0 Pyridoxal-phosphate dependent enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005564 321.0
HKD2_k127_10130950_1 Belongs to the PAPS reductase family. CysH subfamily K00390 GO:0003674,GO:0003824,GO:0004604,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0044424,GO:0044464,GO:0055114 1.8.4.10,1.8.4.8 0.000000000000000000000000000000787 140.0
HKD2_k127_10130950_2 phosphatidylserine decarboxylase K01613 - 4.1.1.65 0.0000000000000000000001597 102.0
HKD2_k127_10195264_0 Domain of unknown function (DUF2088) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001257 291.0
HKD2_k127_10195264_1 conserved protein related to pyruvate formate-lyase activating enzyme K07129 - - 0.00000000000000000000000000000000000000000000000001245 186.0
HKD2_k127_10195264_2 Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs K02936 GO:0000470,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000004483 147.0
HKD2_k127_10195264_3 Belongs to the eukaryotic ribosomal protein eS28 family K02979 - - 0.0000000000000000000000004102 106.0
HKD2_k127_10195264_4 Binds to the 23S rRNA K02896 - - 0.000000000000000000002249 95.0
HKD2_k127_10195264_5 Periplasmic copper-binding protein (NosD) - - - 0.000000000001168 81.0
HKD2_k127_10195264_6 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000526 63.0
HKD2_k127_10195264_7 Pectate lyase K01728 - 4.2.2.2 0.00008661 49.0
HKD2_k127_102933_0 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591,K13421 GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10,4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003079 314.0
HKD2_k127_102933_1 Glycosyltransferase family 28 C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 301.0
HKD2_k127_102933_2 Iron-sulfur cluster-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001721 275.0
HKD2_k127_102933_3 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008381 260.0
HKD2_k127_102933_4 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000002586 188.0
HKD2_k127_102933_5 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000002237 173.0
HKD2_k127_102933_6 Starch synthase catalytic domain - - - 0.0000000000000000000000000000000000000002632 157.0
HKD2_k127_102933_7 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000058 140.0
HKD2_k127_1035924_0 B12 binding domain - - - 0.000000000000000000000000000000000000000000000257 183.0
HKD2_k127_1035924_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000001509 140.0
HKD2_k127_1035924_2 - - - - 0.00000000000005199 86.0
HKD2_k127_1035924_3 - - - - 0.0000608 53.0
HKD2_k127_1065075_0 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 1.463e-240 749.0
HKD2_k127_1065075_1 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005837 394.0
HKD2_k127_1065075_2 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000000000000000000000002141 200.0
HKD2_k127_1072861_0 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000000000000000005989 267.0
HKD2_k127_1072861_1 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000001479 260.0
HKD2_k127_1072861_2 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0000000000001654 76.0
HKD2_k127_1092212_0 acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002417 435.0
HKD2_k127_1092212_1 PFAM AMP-dependent synthetase and ligase K01895 - 6.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 404.0
HKD2_k127_1098399_0 Required for chromosome condensation and partitioning K03529 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001914 286.0
HKD2_k127_1098399_1 cell wall organization - - - 0.0000000000000000000007719 111.0
HKD2_k127_1146021_0 transferase activity, transferring glycosyl groups K01365,K14475 - 3.4.22.15 0.0000000000000000000000000000000000000003733 162.0
HKD2_k127_1146021_1 Membrane protein of unknown function DUF63 - - - 0.000000000000000005804 93.0
HKD2_k127_1159004_0 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001544 364.0
HKD2_k127_1159004_1 Belongs to the PdaD family K02626 - 4.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000001892 254.0
HKD2_k127_1159004_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000000000000059 203.0
HKD2_k127_1159004_3 Belongs to the UPF0215 family K09120 - - 0.0000000000000000000000000000000000000000000000000003624 190.0
HKD2_k127_1159004_4 metal-dependent protease of the PAD1 JAB1 superfamily - - - 0.000000000000000000000000000000007512 131.0
HKD2_k127_1159004_5 Bacterial PH domain - - - 0.0000000003077 72.0
HKD2_k127_1159004_6 Nitrite and sulphite reductase 4Fe-4S - - - 0.000000002025 60.0
HKD2_k127_1163163_0 PAS fold - - - 0.00000000000000000000000000000000000000000000000001136 200.0
HKD2_k127_1189034_0 Glycosyl Transferase K20444 - - 0.00000000000000000000000001321 121.0
HKD2_k127_1189034_1 ubiE/COQ5 methyltransferase family - - - 0.00000003705 60.0
HKD2_k127_119637_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007255 338.0
HKD2_k127_119637_1 ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K17686 - 3.6.3.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002796 281.0
HKD2_k127_119637_2 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.000000000000000000000000000000000000000001208 162.0
HKD2_k127_119637_3 Peptidase_C39 like family - - - 0.00000000000000000002669 97.0
HKD2_k127_1221538_0 TIGRFAM anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 2.203e-234 734.0
HKD2_k127_1221538_1 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000000000000000000000697 213.0
HKD2_k127_1221538_2 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000000000000000000000526 184.0
HKD2_k127_1221538_3 SMART Excinuclease ABC, C subunit - - - 0.0000000000000000000000000000000000009226 143.0
HKD2_k127_1221538_4 CutA1 divalent ion tolerance protein K03926 - - 0.00000000000000000000002943 104.0
HKD2_k127_1221538_5 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives - - - 0.0000000000000000002049 92.0
HKD2_k127_1221538_6 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 0.00001206 47.0
HKD2_k127_1280737_0 AAA domain K07028 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002615 360.0
HKD2_k127_1280737_1 Diphthamide K07561 - 2.5.1.108 0.0000000000000000000000000000000000000000000000000004554 190.0
HKD2_k127_1289197_0 Belongs to the sulfur carrier protein TusA family K04085 - - 0.000000000000000000000000000002707 123.0
HKD2_k127_1289197_1 alginic acid biosynthetic process - - - 0.000003198 55.0
HKD2_k127_1376097_0 domain protein - - - 0.00000000000000000006936 103.0
HKD2_k127_138016_0 TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 341.0
HKD2_k127_138016_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001547 312.0
HKD2_k127_138016_2 PFAM ABC transporter related K01990 - - 0.000001216 50.0
HKD2_k127_1412058_0 Aldehyde ferredoxin oxidoreductase, N-terminal domain K03738 - 1.2.7.5 2.038e-275 867.0
HKD2_k127_1412058_1 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.000000000000000000000000000000000000000000000000009174 192.0
HKD2_k127_1412058_2 Bacterial regulatory helix-turn-helix protein, lysR family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000005835 173.0
HKD2_k127_1412058_3 4 iron, 4 sulfur cluster binding K00196 - - 0.00000000000000000000000000000004414 131.0
HKD2_k127_1412058_4 Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family K03057 GO:0000428,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030880,GO:0031323,GO:0031326,GO:0032991,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061695,GO:0065007,GO:0080090,GO:1902494,GO:1903506,GO:1990234,GO:2000112,GO:2001141 - 0.00000000000000000000000003413 110.0
HKD2_k127_1412058_5 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function - - - 0.000000000000000000000109 106.0
HKD2_k127_1412058_6 Molybdopterin guanine dinucleotide synthesis protein B K03753,K13818 - 2.7.7.77 0.0000000000000002072 87.0
HKD2_k127_1412058_7 Periplasmic binding protein K02016 - - 0.000000000006571 74.0
HKD2_k127_1412058_9 Fosmidomycin resistance protein K08223 - - 0.0000006994 61.0
HKD2_k127_141466_0 Belongs to the universal ribosomal protein uL16 family K02866 - - 0.0000000000000000000000000000000000000000000000000000001311 199.0
HKD2_k127_141466_1 Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs K06176 - 5.4.99.27 0.00000000000000000000000000000000000000000000005285 175.0
HKD2_k127_141466_2 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs K07573 - - 0.00000000000000000000000000000000000001299 151.0
HKD2_k127_141466_3 Peptidase family M50 - - - 0.00000000000000000000004436 109.0
HKD2_k127_141466_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03056 - 2.7.7.6 0.00004319 48.0
HKD2_k127_143064_0 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000006276 247.0
HKD2_k127_143064_1 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase K07559 - - 0.0000000000000000000000000000000000000000000000000000000001474 214.0
HKD2_k127_143064_2 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000001345 181.0
HKD2_k127_143064_3 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.1.1.65 0.00000000000000000000000000000949 122.0
HKD2_k127_143064_4 COG0170 Dolichol kinase - - - 0.000004625 57.0
HKD2_k127_143064_5 hydrophobe amphiphile efflux-3 (HAE3) family K07003 - - 0.0001189 52.0
HKD2_k127_144522_0 by modhmm K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002396 347.0
HKD2_k127_144522_1 NmrA-like family - - - 0.0000000000000000007023 90.0
HKD2_k127_1464992_0 Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA K04795 - - 0.00000000000000000000000000000000000000000000000000006025 194.0
HKD2_k127_1464992_1 Polyprenyl synthetase K02523,K13787 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.00000000000000000000000003864 120.0
HKD2_k127_1472492_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 434.0
HKD2_k127_1472492_1 phosphoglycerate kinase activity K00927 - 2.7.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005677 305.0
HKD2_k127_1472492_2 MiaB-like tRNA modifying enzyme K15865 - 2.8.4.5 0.0000000000000000000000000000000000005125 144.0
HKD2_k127_1485620_0 Parallel beta-helix repeats - - - 0.00006128 52.0
HKD2_k127_1487970_0 Aminopeptidase I zinc metalloprotease (M18) K01267 - 3.4.11.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002833 459.0
HKD2_k127_1487970_1 radical SAM domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004031 311.0
HKD2_k127_1487970_2 - K03741 - 1.20.4.1 0.000000000001518 72.0
HKD2_k127_1497599_0 Peptidase family C25 - - - 0.00000000000000000000000000000000000000000000000000000000000001698 244.0
HKD2_k127_1497599_1 Protein of unknown function (DUF1624) - - - 0.000000000000000000000000000000000000000003883 164.0
HKD2_k127_1497599_2 - - - - 0.000000000005125 80.0
HKD2_k127_1518740_0 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.00000000000003003 81.0
HKD2_k127_1538462_0 cell wall organization - - - 0.0000000000000001 92.0
HKD2_k127_1582846_0 FG-GAP repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 398.0
HKD2_k127_1582846_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000000000000001461 100.0
HKD2_k127_1582846_2 thiolester hydrolase activity K01259,K06889,K21193 - 3.4.11.5 0.00002281 51.0
HKD2_k127_1649783_0 Glycerate kinase K11529 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016491,GO:0016661,GO:0016662,GO:0016740,GO:0016772,GO:0043798,GO:0044237,GO:0055114 2.7.1.165 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009877 304.0
HKD2_k127_1649783_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000006127 264.0
HKD2_k127_1696925_0 4fe-4S ferredoxin, iron-sulfur binding domain protein K03388,K16885,K16886 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0 1030.0
HKD2_k127_1696925_1 4Fe-4S dicluster domain - - - 0.00000008084 56.0
HKD2_k127_1697074_0 Belongs to the complex I 20 kDa subunit family K18023 - 1.12.7.2 0.0000000000000000000000000000000000000000000000000000000000000000001223 231.0
HKD2_k127_1697074_1 PFAM NADH dehydrogenase (ubiquinone), 30 kDa subunit K18017 - 1.12.7.2 0.000000000000000000000000000000000000003811 152.0
HKD2_k127_1697074_2 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K18016 - 1.12.7.2 0.000000000000000000000003961 103.0
HKD2_k127_1705524_0 PFAM Nitroreductase - - - 0.0000000001313 69.0
HKD2_k127_171905_0 Chlorophyllase - - - 0.000000000000000000000000000000000000000000000000000000000000002924 229.0
HKD2_k127_171905_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000009071 192.0
HKD2_k127_171905_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000003204 192.0
HKD2_k127_171905_3 PAS domain - - - 0.000000000000000000000000000000000000000001919 170.0
HKD2_k127_1754851_0 SMART AAA ATPase K07331 - - 0.000000000000000000000000000000000000001384 156.0
HKD2_k127_1754851_1 flagella protein K07327,K07328 - - 0.0000000000000000000004176 106.0
HKD2_k127_1754851_2 PFAM Type II secretion system protein E K07332 - - 0.0000000000000000002874 93.0
HKD2_k127_1754851_3 Archaebacterial flagellin K07330 - - 0.00000000000000002238 87.0
HKD2_k127_1754851_4 Archaeal flagellar protein F K07329 - - 0.0000000241 61.0
HKD2_k127_1754851_5 PFAM Flagella accessory C family protein K07822 - - 0.00001039 56.0
HKD2_k127_1779113_0 PFAM Type II secretion system F domain K07333 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001698 271.0
HKD2_k127_1779113_1 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.00000000000000000000000000000000003484 143.0
HKD2_k127_1779113_2 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.00000000000000000000000000000002196 134.0
HKD2_k127_1779113_3 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.0002688 44.0
HKD2_k127_1797819_0 PFAM peptidase M19 renal dipeptidase K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000004617 186.0
HKD2_k127_1797819_1 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000002436 59.0
HKD2_k127_1798534_0 Glutamine amidotransferase domain K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001449 615.0
HKD2_k127_1798534_1 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000003687 80.0
HKD2_k127_1810454_0 Belongs to the metallo-dependent hydrolases superfamily. HutI family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006193 435.0
HKD2_k127_1810454_1 Formiminotransferase-cyclodeaminase K00603,K01746,K13990 - 2.1.2.5,4.3.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 365.0
HKD2_k127_1810454_2 cyclohydrolase K01746 - 4.3.1.4 0.0000000000000000000000000000000000000000000000000006589 193.0
HKD2_k127_1810454_3 PFAM HhH-GPD family protein K07457 - - 0.00000003135 55.0
HKD2_k127_1815531_0 OPT oligopeptide transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007572 436.0
HKD2_k127_1815531_1 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000006716 262.0
HKD2_k127_1815531_2 Diphthamide synthase K06927 - 6.3.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000006641 250.0
HKD2_k127_1815531_3 (AIR) carboxylase K06898 - - 0.0000000000000000000000000000000000000000000000000000000000000000000008565 241.0
HKD2_k127_1815531_4 purine-nucleoside phosphorylase activity K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000001042 198.0
HKD2_k127_1815531_5 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - - - 0.00000000000000000000000000000001295 130.0
HKD2_k127_1815531_6 cluster protein-associated redox disulfide domain - - - 0.00000000000001725 77.0
HKD2_k127_1815531_7 Coenzyme PQQ synthesis protein D (PqqD) - - - 0.0009133 46.0
HKD2_k127_1838557_0 Membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000567 221.0
HKD2_k127_1838557_1 Universal stress protein - - - 0.0000000000000000000002352 102.0
HKD2_k127_1838557_2 Domain of unknown function (DUF4922) - - - 0.0000000000007309 70.0
HKD2_k127_1845584_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 0.00000000000000000000000000001433 121.0
HKD2_k127_1845584_1 cysteine-type peptidase activity K08589 - 3.4.22.37 0.0000000122 68.0
HKD2_k127_1849527_0 CoA binding domain K01905 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 376.0
HKD2_k127_1849527_1 pre-rRNA processing protein involved in ribosome biogenesis K09140 - - 0.0000001179 53.0
HKD2_k127_1888463_0 Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs K07583 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003401 329.0
HKD2_k127_1888463_1 Protein of unknown function (DUF655) K07572 - - 0.00000000000000000000000000000000000000000000000000005236 191.0
HKD2_k127_1888463_2 Belongs to the eukaryotic ribosomal protein eL21 family K02889 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000006098 102.0
HKD2_k127_1888463_3 RNA polymerase Rpb4 K03051 - 2.7.7.6 0.00000000000000127 80.0
HKD2_k127_190071_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003213 309.0
HKD2_k127_190071_1 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03238 - - 0.000000000000000000000000000000000000000000000000000000007908 205.0
HKD2_k127_190071_2 transcriptional regulators containing the CopG Arc MetJ DNA-binding domain - - - 0.00009549 48.0
HKD2_k127_1921761_0 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 4.136e-203 642.0
HKD2_k127_1928413_0 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000009724 121.0
HKD2_k127_1928413_1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015 - 1.1.1.26 0.000000000000000000000282 98.0
HKD2_k127_1928413_2 Pectate lyase - - - 0.00002112 57.0
HKD2_k127_1947001_0 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001324 274.0
HKD2_k127_1947001_1 Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides K05685 - - 0.000000937 60.0
HKD2_k127_1964954_0 Putative zinc- or iron-chelating domain K06940 - - 0.00000000000000000003353 95.0
HKD2_k127_1964954_1 Peptidase family C25 - - - 0.0000000054 68.0
HKD2_k127_1964954_2 helix_turn_helix ASNC type K03719 - - 0.00007398 52.0
HKD2_k127_2001431_0 PFAM Citrate lyase, alpha subunit K01643 - 2.8.3.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007015 458.0
HKD2_k127_2001431_1 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002809 342.0
HKD2_k127_2001431_2 Belongs to the citrate synthase family K01647,K15234 - 2.3.3.1,4.1.3.34 0.000000000000000000000000000000000000000000000000000000000000000000000001189 253.0
HKD2_k127_2001431_3 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - 0.00000000000005034 81.0
HKD2_k127_2003520_0 PFAM Pyruvate flavodoxin ferredoxin oxidoreductase K00174 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 544.0
HKD2_k127_2003520_1 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00175 - 1.2.7.11,1.2.7.3 0.000000000000000000000000000000000000000000000000000000000002312 210.0
HKD2_k127_2016008_0 COGs COG1033 exporter of the RND superfamily protein K07003 - - 0.0000000000000004384 93.0
HKD2_k127_2023039_0 PFAM PKD domain containing protein - - - 0.0000000000006749 75.0
HKD2_k127_2023039_1 PKD domain containing protein - - - 0.0001023 50.0
HKD2_k127_2029140_0 PKD domain - - - 0.0000000000001862 81.0
HKD2_k127_2029140_1 cellulase activity K01178,K14645,K18546 - 3.2.1.3 0.00000003116 65.0
HKD2_k127_2040029_0 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000000000000001295 263.0
HKD2_k127_2040029_1 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179,K17105 - 2.5.1.39,2.5.1.42 0.0000000000000000000000000001978 120.0
HKD2_k127_2040029_2 alcohol dehydrogenase - - - 0.00000000000008643 79.0
HKD2_k127_2042334_0 2Fe-2S iron-sulfur cluster binding domain K00302 - 1.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000122 479.0
HKD2_k127_2042334_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03042 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001201 365.0
HKD2_k127_2042334_2 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000007608 138.0
HKD2_k127_2042334_3 Participates in transcription termination K02600 - - 0.00000000000000000000000000002962 124.0
HKD2_k127_2042334_4 BFD-like 2Fe-2S binding domain - - - 0.00000000002045 64.0
HKD2_k127_2042334_5 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family K02908 - - 0.0000000003042 64.0
HKD2_k127_2069105_0 arsenite transmembrane transporter activity K03893 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008490,GO:0008509,GO:0015075,GO:0015103,GO:0015104,GO:0015105,GO:0015291,GO:0015318,GO:0015698,GO:0015699,GO:0015700,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042960,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656 - 0.0000000000000000000000000000000000000000000000004621 185.0
HKD2_k127_2069105_1 Belongs to the peptidase S8 family K14645 - - 0.000000000000000000000003891 117.0
HKD2_k127_2069105_2 PFAM Nitroreductase - - - 0.000000000000000000000111 100.0
HKD2_k127_2072375_0 TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain K02031,K02032,K15583 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002381 408.0
HKD2_k127_2072375_1 TIGRFAM oligopeptide dipeptide ABC transporter, ATP-binding protein, C-terminal domain K02032,K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002271 378.0
HKD2_k127_2072375_2 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 319.0
HKD2_k127_2099907_0 Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis K18933 - 4.1.1.11,4.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 321.0
HKD2_k127_2099907_1 Belongs to the MEMO1 family K06990 - - 0.00000000000000000000000000000000000000000000000000000006231 202.0
HKD2_k127_2099907_2 Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis K00759 - 2.4.2.7 0.00000000000000000000000000000000000000000000000000002361 193.0
HKD2_k127_2099907_3 - - - - 0.000006353 50.0
HKD2_k127_2099907_4 Uncharacterized protein containing a Zn-ribbon (DUF2116) - - - 0.0001065 48.0
HKD2_k127_2173716_0 cell redox homeostasis - - - 0.0000000000000000000000000000000000000000000000000000003158 204.0
HKD2_k127_2173716_1 Archaeal Type IV pilin, N-terminal - - - 0.00000007101 63.0
HKD2_k127_2237694_0 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003816 271.0
HKD2_k127_2237694_1 ABC-type transport system involved in multi-copper enzyme maturation permease component K01992,K19341 - - 0.000000000000000000000000000000001341 136.0
HKD2_k127_2242881_0 Subtilase family - - - 0.0000000000000000088 98.0
HKD2_k127_2242881_1 PFAM NHL repeat containing protein - - - 0.0000000000000001068 95.0
HKD2_k127_2281603_0 Protein of unknown function DUF89 K09116 - - 0.00000000000000000000000000000000000000000000000000000000000000000001279 246.0
HKD2_k127_2289618_0 Protein of unknown function DUF45 K07043 - - 0.000000000000000000007518 97.0
HKD2_k127_2359421_0 B3/4 domain K01890 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 427.0
HKD2_k127_2362510_0 zinc-ribbon domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004269 403.0
HKD2_k127_2362510_1 metal-dependent membrane protease K07052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002971 282.0
HKD2_k127_2362510_2 - - - - 0.00000000000000000000000000000000000007836 148.0
HKD2_k127_2362510_3 Protein of unknown function (DUF3795) - - - 0.0000000000000000000000000000002232 128.0
HKD2_k127_2362510_4 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.0000000000000000000002237 105.0
HKD2_k127_2362510_5 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA - - - 0.0001309 53.0
HKD2_k127_2386140_0 Arylsulfotransferase (ASST) - - - 0.000000000000000000000000000000000000000000000000000000000000003311 227.0
HKD2_k127_2406025_0 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 - - 0.0000000000000000000000000000000000000000000000000000000003288 205.0
HKD2_k127_2406025_1 Transcription elongation factor Spt5 K02601 GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0005488,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006357,GO:0006366,GO:0006368,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016071,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000006491 141.0
HKD2_k127_2406025_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000000005786 93.0
HKD2_k127_2409087_0 Acyl-protein synthetase, LuxE - - - 0.0000000000000000000000000000008091 136.0
HKD2_k127_2409087_1 Sterol carrier protein - - - 0.000000002629 63.0
HKD2_k127_2427383_0 Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur K03146 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 298.0
HKD2_k127_2427383_1 DNA primase K02316 - - 0.000000000000000000000000000000000000000000000000000000000001235 218.0
HKD2_k127_2427383_2 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0000000000000000000000000000000000000000000003757 167.0
HKD2_k127_2427383_3 Acetyltransferase (GNAT) domain K03789 - 2.3.1.128 0.00000000000000000000004909 104.0
HKD2_k127_2427383_4 - - - - 0.000000000000001929 82.0
HKD2_k127_2427383_5 Uncharacterised protein family UPF0058 - - - 0.0000001262 57.0
HKD2_k127_2449885_0 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 307.0
HKD2_k127_2449885_1 Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate K02437 GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 - 0.00000000000000000000000000000000000000003899 155.0
HKD2_k127_2449885_2 FIST_C - - - 0.0000000007411 71.0
HKD2_k127_2451317_0 PQQ enzyme repeat - - - 0.0000000000000000000000000112 126.0
HKD2_k127_2451317_1 Response regulator receiver domain protein - - - 0.00001581 48.0
HKD2_k127_2451317_2 COG1522 Transcriptional regulators - - - 0.00002165 56.0
HKD2_k127_2495892_0 RmlD substrate binding domain K01709 - 4.2.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 319.0
HKD2_k127_2495892_1 parallel beta-helix repeat K03671 - - 0.000000002944 68.0
HKD2_k127_2533291_0 Peptidase S9 prolyl oligopeptidase active site K01281 - 3.4.14.11 0.000000000000000000000000000000000000000000000000000000000000007711 224.0
HKD2_k127_2533291_1 histidine kinase A domain protein - - - 0.0000000000000000002236 96.0
HKD2_k127_2584897_0 Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily K00955,K00956 - 2.7.1.25,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000002253 224.0
HKD2_k127_2584897_1 Catalyzes the synthesis of activated sulfate K00390,K00860,K00958,K13811 GO:0000096,GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0004779,GO:0004781,GO:0006082,GO:0006520,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010134,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0019379,GO:0019419,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0070566,GO:0071704,GO:1901564 1.8.4.10,1.8.4.8,2.7.1.25,2.7.7.4 0.0000000000000000000000000000000000000000000000000000000000000141 220.0
HKD2_k127_2606238_0 helicase superfamily c-terminal domain K10896 - - 1.116e-202 655.0
HKD2_k127_2606238_1 Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.000000000000000000000000000000000000000000000000000000001534 210.0
HKD2_k127_2606238_2 Protein of unknown function (DUF655) K07572 - - 0.0000000000000000000000000005583 115.0
HKD2_k127_2641028_0 tRNA synthetases class I (E and Q), anti-codon binding domain K01886 GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 2.101e-231 723.0
HKD2_k127_2641028_1 Clostripain family - - - 0.0000000000000000000004388 111.0
HKD2_k127_2641028_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000003392 84.0
HKD2_k127_2661377_0 secreted hydrolase - - - 0.0000000007621 71.0
HKD2_k127_2698112_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000001164 57.0
HKD2_k127_2726514_0 PFAM Aldehyde dehydrogenase K00294 - 1.2.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003136 403.0
HKD2_k127_2726514_1 Intracellular protease, PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000000000000000000000001026 240.0
HKD2_k127_2726514_2 Universal stress protein - - - 0.00000000000000000000001405 104.0
HKD2_k127_276931_0 methylase K07446 - 2.1.1.213 0.000000000000000000000000000000000000000001365 165.0
HKD2_k127_276931_1 TIGRFAM bifunctional phosphoglucose phosphomannose isomerase K15916 - 5.3.1.8,5.3.1.9 0.0000000000000000000000000000000009795 136.0
HKD2_k127_2780332_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03166 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0016889,GO:0016894,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0061505,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001105 494.0
HKD2_k127_2851524_0 Type II secretion system (T2SS), protein F K07333 - - 0.0000000000000005848 82.0
HKD2_k127_2851524_1 metallopeptidase activity K01637 - 4.1.3.1 0.00000009435 64.0
HKD2_k127_2851524_2 PKD domain containing protein - - - 0.0009855 51.0
HKD2_k127_2874132_0 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 371.0
HKD2_k127_2874132_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002679 331.0
HKD2_k127_2874132_2 PFAM metallophosphoesterase K06953 - - 0.00000000000000000000000000000000000000000000000000000001627 205.0
HKD2_k127_2904658_0 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate K03517 - 2.5.1.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001946 351.0
HKD2_k127_2904658_1 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.000000000000000000000000000000000000000000000004551 175.0
HKD2_k127_2907455_0 AAA domain - - - 0.00000000000000000000000000008239 125.0
HKD2_k127_2907455_1 Peptidase C10 family - - - 0.00000000000000001129 98.0
HKD2_k127_291125_0 Alanine-glyoxylate amino-transferase K05825 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000865 340.0
HKD2_k127_293240_0 PFAM type II secretion system protein E K07332 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005174 438.0
HKD2_k127_293240_1 PFAM type II secretion system K07333 - - 0.000000000000000000000001417 115.0
HKD2_k127_2946391_0 PQQ enzyme repeat K05889,K12132 - 1.1.2.6,2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000007262 252.0
HKD2_k127_2946391_1 Arylsulfotransferase (ASST) - - - 0.000000000000000000000000000000000000000000000000000000528 197.0
HKD2_k127_2946391_2 Archaeal Type IV pilin, N-terminal - - - 0.000000000002333 80.0
HKD2_k127_29522_0 Arylsulfotransferase (ASST) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003578 406.0
HKD2_k127_29522_1 PFAM methyl-viologen-reducing hydrogenase delta subunit K14127 - 1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000000000000000000000005633 210.0
HKD2_k127_29522_2 Evidence 5 No homology to any previously reported sequences K01361,K13277 - 3.4.21.96 0.0000000000000000000000000000000000000000000001303 184.0
HKD2_k127_29522_3 Hydrogenase maturation protease K03605 - - 0.0000000000000000000000000503 112.0
HKD2_k127_29522_4 Nickel-dependent hydrogenase K14126 - 1.8.98.5 0.00000000000000002089 82.0
HKD2_k127_29522_5 Protein of unknown function (DUF1349) - - - 0.0000000000000005022 91.0
HKD2_k127_3013284_0 Oxidoreductase family, C-terminal alpha beta domain K13016 - 1.1.1.335 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007912 448.0
HKD2_k127_3013284_1 Cys/Met metabolism PLP-dependent enzyme - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000222 268.0
HKD2_k127_3013284_2 Hexapeptide repeat of succinyl-transferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002705 231.0
HKD2_k127_3013284_3 Succinoglycan biosynthesis protein exoa - - - 0.00000000000000000000000000000000000009549 154.0
HKD2_k127_30212_0 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001966 258.0
HKD2_k127_30212_1 TIGRFAM PAS sensor protein - - - 0.00000000000000000000000000000000000000000000000000000000000000004869 243.0
HKD2_k127_30212_3 thiolester hydrolase activity K06889 GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0052689 - 0.0000000000000000000000000000000000000000000000000001218 192.0
HKD2_k127_30212_4 cheY-homologous receiver domain K07668 - - 0.000000000000000373 80.0
HKD2_k127_30212_5 Bacterial Ig-like domain (group 3) - - - 0.00000000005198 75.0
HKD2_k127_306081_0 belongs to the glycosyl hydrolase 13 family K01176,K01208 - 3.2.1.1,3.2.1.133,3.2.1.135,3.2.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001517 299.0
HKD2_k127_306081_1 - - - - 0.00000000000000001338 83.0
HKD2_k127_306081_2 bacterial-type flagellum-dependent cell motility - - - 0.00000000404 70.0
HKD2_k127_306081_3 positive regulation of nitrogen compound metabolic process K04097,K09213,K17298,K22493 - 2.5.1.18,5.3.99.2 0.0000000243 59.0
HKD2_k127_306081_4 Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0007678 48.0
HKD2_k127_3107871_0 PFAM AMP-dependent synthetase K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 467.0
HKD2_k127_3107871_1 Right handed beta helix region - - - 0.00000000000268 79.0
HKD2_k127_3108918_0 Belongs to the glycosyl hydrolase 57 family K07405 - 3.2.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002511 450.0
HKD2_k127_3108918_1 PFAM Glycosyl transferase, group 1 - GO:0003674,GO:0003824,GO:0016740,GO:0016757 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001418 429.0
HKD2_k127_3108918_2 Starch synthase catalytic domain - - - 0.0000000000000000000000000000000000000000000001377 172.0
HKD2_k127_3108918_3 TIGRFAM glycogen debranching enzyme - - - 0.0000000000000000000001678 104.0
HKD2_k127_3132381_0 synthetase (ADP forming), alpha K01905,K09181,K22224 GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564 6.2.1.13 5.171e-264 842.0
HKD2_k127_3132381_1 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003772 306.0
HKD2_k127_3132381_2 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000005406 206.0
HKD2_k127_3132381_3 PFAM Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000001745 208.0
HKD2_k127_3132381_4 pfam nmd3 K07562 - - 0.0000000000000000000002236 102.0
HKD2_k127_3140574_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 3.333e-209 688.0
HKD2_k127_3140574_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001791 425.0
HKD2_k127_3148738_0 Radical SAM superfamily K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 426.0
HKD2_k127_3148738_1 Phosphoribosyl transferase domain K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000000009885 239.0
HKD2_k127_3148738_2 Thioredoxin - - - 0.00000000000000000000000000000004645 128.0
HKD2_k127_3153342_0 alcohol dehydrogenase K00100,K19955 GO:0003674,GO:0003824,GO:0004022,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001501 360.0
HKD2_k127_3153342_1 Sodium/hydrogen exchanger family - - - 0.000000000000000000000000000000000000000000005741 180.0
HKD2_k127_315412_0 Right handed beta helix region - - - 0.000000000000000000000000000000000000000000000000000000000001223 232.0
HKD2_k127_3200818_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000456 370.0
HKD2_k127_3200818_1 Phosphomethylpyrimidine kinase K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.0000000000009751 69.0
HKD2_k127_3209593_0 PFAM Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000158 288.0
HKD2_k127_3209593_1 PFAM SNARE associated Golgi protein - - - 0.000000000000000000000000000000000000000000000000000000000001503 218.0
HKD2_k127_3209593_2 lactate metabolic process - - - 0.0000000000006715 79.0
HKD2_k127_3222794_0 Spermatogenesis associated 5 K13525,K14575 GO:0001655,GO:0001657,GO:0001658,GO:0001763,GO:0001822,GO:0001823,GO:0001932,GO:0001933,GO:0002009,GO:0003674,GO:0003824,GO:0004857,GO:0004860,GO:0005102,GO:0005178,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006469,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0008150,GO:0009653,GO:0009887,GO:0009888,GO:0009892,GO:0010563,GO:0010594,GO:0010595,GO:0010605,GO:0010632,GO:0010634,GO:0010941,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019887,GO:0019899,GO:0019900,GO:0019901,GO:0022603,GO:0030234,GO:0030334,GO:0030335,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032879,GO:0033673,GO:0035239,GO:0035295,GO:0040012,GO:0040017,GO:0042325,GO:0042326,GO:0043086,GO:0043535,GO:0043536,GO:0043549,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0045765,GO:0045766,GO:0045859,GO:0045936,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048729,GO:0048731,GO:0048754,GO:0048856,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050839,GO:0051094,GO:0051171,GO:0051172,GO:0051174,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051270,GO:0051272,GO:0051338,GO:0051348,GO:0060255,GO:0060322,GO:0060429,GO:0060548,GO:0060562,GO:0060675,GO:0060993,GO:0061138,GO:0061326,GO:0061333,GO:0065007,GO:0065009,GO:0072001,GO:0072006,GO:0072009,GO:0072028,GO:0072073,GO:0072078,GO:0072080,GO:0072088,GO:0072163,GO:0072164,GO:0072171,GO:0080090,GO:0090049,GO:0090050,GO:0098772,GO:1901342,GO:1903670,GO:1903672,GO:1904018,GO:2000026,GO:2000145,GO:2000147 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008942 433.0
HKD2_k127_3222794_1 Involved in regulation of DNA replication K10725 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006518 265.0
HKD2_k127_3222794_2 Involved in regulation of DNA replication K10725 - - 0.00000000000000000000000002977 110.0
HKD2_k127_3222794_3 PRC-barrel domain - - - 0.0000000000000009228 79.0
HKD2_k127_3271652_0 PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit K00584 - 2.1.1.86 0.0000000000000000000000000000000000000000000009571 177.0
HKD2_k127_3271652_1 Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step K00577 - 2.1.1.86 0.0000000001082 65.0
HKD2_k127_3271652_2 Methionine synthase K00549 - 2.1.1.14 0.00000001684 62.0
HKD2_k127_3367265_0 Transcriptional regulator, AbiEi antitoxin - - - 0.0000000000002844 74.0
HKD2_k127_3367265_1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.0000000002909 72.0
HKD2_k127_34_0 ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001569 416.0
HKD2_k127_3401375_0 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005219 338.0
HKD2_k127_3401375_1 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.0000000000000000000000000000000000000000000000000000000000000000001057 233.0
HKD2_k127_3408596_0 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.000000000000000000000000000003796 123.0
HKD2_k127_3408596_1 Parallel beta-helix - - - 0.0000000000363 74.0
HKD2_k127_3418527_0 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.0000000000000000000000000000000004038 141.0
HKD2_k127_3418712_0 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant K03465 - 2.1.1.148 0.0000000000000000000000000000000000000000000000000000000000000000003108 235.0
HKD2_k127_3418712_1 RibD C-terminal domain K14654 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046983,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.302 0.0000000000000000000000000000000000000000000000003393 183.0
HKD2_k127_3418712_2 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.1.1.65 0.00000000000000000000000000000000000000004546 159.0
HKD2_k127_3418712_3 PFAM Transmembrane exosortase (Exosortase_EpsH) - - - 0.00000000000000000000006681 109.0
HKD2_k127_3418712_4 PFAM Peptidase C1A, papain - - - 0.00000000000000000006345 102.0
HKD2_k127_3418712_5 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000000000001821 89.0
HKD2_k127_3418712_6 acid phosphatase activity - - - 0.0000000001604 73.0
HKD2_k127_3422_0 Arylsulfotransferase (ASST) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 400.0
HKD2_k127_3422_1 Protein of unknown function (DUF1015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003463 298.0
HKD2_k127_3422_2 Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002084 286.0
HKD2_k127_3422_3 Lysine exporter protein LysE YggA - - - 0.00000000000000000000000000000000000000751 152.0
HKD2_k127_3422_4 cell wall organization - - - 0.000000000004274 74.0
HKD2_k127_3422_5 Pkd domain containing protein - - - 0.0000006249 62.0
HKD2_k127_3422_6 Protein of unknown function (DUF1015) - - - 0.0000009189 52.0
HKD2_k127_346222_0 HELICc2 K03722,K10844 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000009501 267.0
HKD2_k127_3508310_0 NADPH-dependent FMN reductase - - - 0.00000000000000000000000000000000000000001604 162.0
HKD2_k127_35151_0 transferase activity, transferring glycosyl groups K05889 - 1.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005633 341.0
HKD2_k127_35151_1 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K02029 - - 0.00000000000000000000000000000000000000000000000000000000000000000103 234.0
HKD2_k127_35151_2 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.000003965 49.0
HKD2_k127_35151_3 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0002762 52.0
HKD2_k127_3523008_0 Belongs to the phosphohexose mutase family K01840,K03431,K15778 - 5.4.2.10,5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000001426 273.0
HKD2_k127_3523008_1 Transferase hexapeptide repeat K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000000000000000002942 213.0
HKD2_k127_3523008_2 Belongs to the phosphohexose mutase family K15778 - 5.4.2.2,5.4.2.8 0.00000000000000000000000000000000000000000000000000009263 196.0
HKD2_k127_3523008_3 Caspase domain - - - 0.00000001509 65.0
HKD2_k127_35414_0 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000000000004966 232.0
HKD2_k127_35414_1 tRNA intron endonuclease, catalytic C-terminal domain K01170 GO:0000213,GO:0000379,GO:0000394,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0004549,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:0140101,GO:1901360 4.6.1.16 0.0000000000000000000000000000000000000000000000000000001138 208.0
HKD2_k127_35414_2 Belongs to the peptidase S16 family K06870 - - 0.000000000000000000000000000000000000000000000000002306 201.0
HKD2_k127_35414_3 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00015,K15893 - 1.1.1.26 0.0000000000000000000000000000000000000008674 150.0
HKD2_k127_3595036_0 4fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 7.393e-247 782.0
HKD2_k127_3595036_1 PFAM methyl-viologen-reducing hydrogenase delta subunit K14127 - 1.8.98.5,1.8.98.6 0.000000000000000000000000000000000000000001624 156.0
HKD2_k127_3686164_0 PFAM FAD dependent oxidoreductase K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009921 352.0
HKD2_k127_3686164_1 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000001794 118.0
HKD2_k127_3686164_2 BFD-like [2Fe-2S] binding domain - - - 0.00000000006531 63.0
HKD2_k127_371477_0 Capsular polysaccharide biosynthesis protein CapK K01912 - 6.2.1.30 0.0000000000000003079 86.0
HKD2_k127_371477_1 - - - - 0.000001704 52.0
HKD2_k127_3716160_0 ABC-type multidrug transport system ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005951 329.0
HKD2_k127_3716160_1 PFAM Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000000000000000000004305 164.0
HKD2_k127_3716160_2 SpoVT / AbrB like domain - - - 0.0000000007311 63.0
HKD2_k127_3734395_0 acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001739 507.0
HKD2_k127_3734395_1 PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP K19221 - 2.5.1.17 0.00000000000000000000000000000000000000000000000000000000004123 209.0
HKD2_k127_3734395_2 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 0.000000000000000000000009021 104.0
HKD2_k127_3734395_3 Methylmalonyl-CoA mutase K01847,K01848 - 5.4.99.2 0.000000000000000000003607 95.0
HKD2_k127_3782834_0 tRNA synthetases class I (W and Y) K01867 GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 344.0
HKD2_k127_3793588_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 4.1e-248 785.0
HKD2_k127_3793588_1 SAICAR synthetase K01923 - 6.3.2.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 364.0
HKD2_k127_3793588_2 cell adhesion involved in biofilm formation - - - 0.0000000000000000000000000000002439 142.0
HKD2_k127_3793588_3 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01179,K13276 - 3.2.1.4 0.0000002959 64.0
HKD2_k127_3811961_0 S-adenosyl-l-methionine hydroxide adenosyltransferase K22205 - - 0.00000000000000000000000000000000000000000000000000000000000001658 224.0
HKD2_k127_3811961_1 Flavin reductase like domain - - - 0.0000000000000000000000000000000055 136.0
HKD2_k127_3811961_2 Protein of unknown function (DUF357) K09728 - - 0.000000005406 57.0
HKD2_k127_3815300_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005678 275.0
HKD2_k127_3815300_1 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001744 264.0
HKD2_k127_3815300_10 Ribosomal protein L23 K02892 - - 0.000000000000000004422 88.0
HKD2_k127_3815300_11 Ribosomal L29 protein K02904 - - 0.00000000000000002864 83.0
HKD2_k127_3815300_12 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03538 GO:0000172,GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005732,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0022613,GO:0030677,GO:0032991,GO:0033204,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 0.0000001149 57.0
HKD2_k127_3815300_2 Forms part of the polypeptide exit tunnel K02930 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000001208 261.0
HKD2_k127_3815300_3 Binds the lower part of the 30S subunit head K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005023 256.0
HKD2_k127_3815300_4 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - 0.000000000000000000000000000000000000000000000000001345 185.0
HKD2_k127_3815300_5 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000000000000000001838 160.0
HKD2_k127_3815300_6 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000000000000000000005314 148.0
HKD2_k127_3815300_7 Translation initiation factor SUI1 K03113 GO:0001731,GO:0002181,GO:0002183,GO:0002188,GO:0002190,GO:0002192,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0110017,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000001048 145.0
HKD2_k127_3815300_8 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000002383 133.0
HKD2_k127_3815300_9 Located at the polypeptide exit tunnel on the outside of the subunit K02895 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000001651 108.0
HKD2_k127_3816169_0 PFAM 4-hydroxyphenylacetate 3-hydroxylase N terminal K00483,K14534 - 1.14.14.9,4.2.1.120,5.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 462.0
HKD2_k127_3816169_1 membrane-associated protein domain - - - 0.000000000001008 75.0
HKD2_k127_3818726_0 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000002919 239.0
HKD2_k127_3876953_0 HhH-GPD family K03575 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001087 250.0
HKD2_k127_3886185_0 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000001001 219.0
HKD2_k127_3886185_1 - - - - 0.000000000000000000000000000003706 123.0
HKD2_k127_3886185_2 mechanosensitive ion channel K16052 - - 0.00000000000000000002168 102.0
HKD2_k127_3886185_3 membrane-associated protein domain - - - 0.000002674 58.0
HKD2_k127_3935421_0 Type II/IV secretion system protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009491 471.0
HKD2_k127_3937774_0 Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 339.0
HKD2_k127_3955981_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004225 376.0
HKD2_k127_3955981_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000004884 229.0
HKD2_k127_3955981_2 Pyruvate ferredoxin/flavodoxin oxidoreductase K00180 - 1.2.7.8 0.000000000000000000000000000000000000000000001103 172.0
HKD2_k127_4067222_0 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000001034 163.0
HKD2_k127_4067222_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - 0.0000000000000000000000000000000000001083 149.0
HKD2_k127_4146625_0 Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate K01497 - 3.5.4.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000006175 262.0
HKD2_k127_4146625_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000009723 236.0
HKD2_k127_4146625_2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000001616 205.0
HKD2_k127_4146625_3 Uncharacterized protein family UPF0016 - - - 0.000000000000000000000000000000000000000141 156.0
HKD2_k127_4146625_4 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.00000000000000000000007935 99.0
HKD2_k127_4146625_5 - - - - 0.00000000000002736 74.0
HKD2_k127_4146625_6 Abc transporter K02035 - - 0.000005307 51.0
HKD2_k127_4147581_0 Cation transporter/ATPase, N-terminus K01537 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003266 543.0
HKD2_k127_4147581_1 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 368.0
HKD2_k127_4147581_2 MafB19-like deaminase K01493 - 3.5.4.12 0.0000000000000000000000000000000000000000000000000000000000000000001954 231.0
HKD2_k127_4147581_3 Belongs to the peptidase M24B family K01271 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000003067 197.0
HKD2_k127_4147581_4 Transcriptional regulator, TrmB - - - 0.00000000000000000000000004503 111.0
HKD2_k127_415806_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001041 489.0
HKD2_k127_415806_1 - - - - 0.0000000000000000000000000000000000000002428 168.0
HKD2_k127_415806_2 Winged helix DNA-binding domain (DUF1495) K09745 - - 0.0000000000000005187 82.0
HKD2_k127_415806_3 Photosynthesis system II assembly factor YCF48 - - - 0.00000000002054 70.0
HKD2_k127_415806_4 Type II/IV secretion system protein - - - 0.0000000003295 63.0
HKD2_k127_4162287_0 3-demethylubiquinone-9 3-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 383.0
HKD2_k127_4162287_1 Phenazine biosynthesis-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001245 256.0
HKD2_k127_4162287_2 Protein of unknown function (DUF1697) - - - 0.00000000000000000000000000000000000000000000000001147 185.0
HKD2_k127_4162287_3 Domain of unknown function (DU1801) - - - 0.0000000000000000000000000000000000000000000000004545 178.0
HKD2_k127_4162287_4 Domain of unknown function (DUF4382) - - - 0.00002899 55.0
HKD2_k127_4162287_5 bacterial-type flagellum-dependent cell motility - - - 0.0007315 52.0
HKD2_k127_4184226_0 Alanine dehydrogenase/PNT, N-terminal domain K00290,K14157 - 1.5.1.7,1.5.1.8,1.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002373 507.0
HKD2_k127_4184226_1 Saccharopine dehydrogenase C-terminal domain K00293 - 1.5.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001985 493.0
HKD2_k127_4186557_0 transcriptional - - - 0.00000000000000000000000000008287 119.0
HKD2_k127_4201947_0 self proteolysis - - - 0.000002147 60.0
HKD2_k127_420308_0 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007817 329.0
HKD2_k127_420308_1 Belongs to the MCM family K10726 - - 0.0000000008955 64.0
HKD2_k127_4203793_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000000001239 70.0
HKD2_k127_4203793_1 Zinc carboxypeptidase - - - 0.0001198 54.0
HKD2_k127_4221947_0 Arylsulfotransferase (ASST) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007181 352.0
HKD2_k127_4235950_0 Relaxes both positive and negative superturns and exhibits a strong decatenase activity K03167 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007701 318.0
HKD2_k127_4235950_1 Anticodon-binding domain of tRNA K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 0.000000000000000000000000000000006364 130.0
HKD2_k127_4306095_0 - - - - 0.000000000000000000003037 104.0
HKD2_k127_4306095_1 H( )-stimulated, divalent metal cation uptake system - - - 0.000000743 59.0
HKD2_k127_4306095_2 Polysaccharide biosynthesis protein K01710 - 4.2.1.46 0.0007843 43.0
HKD2_k127_4343143_0 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity K00186 - 1.2.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008278 370.0
HKD2_k127_4343143_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00170 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009794 310.0
HKD2_k127_4343143_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000002249 159.0
HKD2_k127_4343143_3 kinase, sugar kinase superfamily K06982 - 2.7.1.169 0.000000000000000000000000000000000003855 148.0
HKD2_k127_4343143_4 TIGRFAM pyruvate ferredoxin flavodoxin oxidoreductase, delta subunit K00171 - 1.2.7.1 0.0000000000000000000000000006621 115.0
HKD2_k127_4363455_0 Transglutaminase-like superfamily - - - 0.000000000000000001706 97.0
HKD2_k127_4363455_1 PFAM conserved K07027 - - 0.0000000003623 71.0
HKD2_k127_4364837_0 COG2041 Sulfite oxidase and related enzymes - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003152 287.0
HKD2_k127_4364837_1 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000004503 111.0
HKD2_k127_4364837_2 Domain of unknown function (DUF4870) - - - 0.0000000000000000001303 92.0
HKD2_k127_4364837_3 - - - - 0.000001046 53.0
HKD2_k127_4364837_4 membrane - - - 0.0005154 48.0
HKD2_k127_4365596_0 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006348 299.0
HKD2_k127_4365596_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001739 258.0
HKD2_k127_4365596_2 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000003824 113.0
HKD2_k127_4434708_0 Peptidase family M28 K05994 - 3.4.11.10 0.000000000000000000000719 109.0
HKD2_k127_444927_0 Catalyzes the conversion of dihydroorotate to orotate K00254,K17828 GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004338 338.0
HKD2_k127_444927_1 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( K02823 - - 0.00000000000000000000000000000000000000000000000000000000000000000005386 239.0
HKD2_k127_444927_2 Helix-turn-helix K07108 - - 0.000000000000002702 79.0
HKD2_k127_4463834_0 PFAM Phosphomethylpyrimidine kinase type-1 K00941,K21219 - 2.5.1.3,2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000005273 148.0
HKD2_k127_4463834_1 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000000000000001124 123.0
HKD2_k127_448028_0 Nucleolar GTP-binding protein 1 (NOG1) K06943 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001521 279.0
HKD2_k127_448028_1 Peptidase family M28 - - - 0.0000000000000000000000000000001785 141.0
HKD2_k127_448028_2 Winged helix DNA-binding domain (DUF1495) K09745 - - 0.00000000000001898 78.0
HKD2_k127_448028_3 Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) K07732 - 2.7.1.161 0.0000000000000358 78.0
HKD2_k127_4504242_0 aminopeptidase K19689 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001091 258.0
HKD2_k127_4504242_1 Lrp/AsnC ligand binding domain - - - 0.000000006327 59.0
HKD2_k127_4526691_0 Pfam:DUF650 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 478.0
HKD2_k127_4526691_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000192 227.0
HKD2_k127_4526691_2 Belongs to the eukaryotic ribosomal protein eS1 family K02984 GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576 - 0.0000000000000000000000000000000000000000000001961 178.0
HKD2_k127_4526691_3 TOPRIM - - - 0.000000000000000003633 89.0
HKD2_k127_4526691_4 Belongs to the UPF0235 family K09131 - - 0.00000000000000004175 84.0
HKD2_k127_4526691_5 Contacts the emerging nascent chain on the ribosome K03626 - - 0.000009263 48.0
HKD2_k127_4545056_0 AIR synthase related protein, C-terminal domain K04655 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001061 380.0
HKD2_k127_4545056_1 Anaerobic ribonucleoside-triphosphate reductase K21636 - 1.1.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002142 297.0
HKD2_k127_4545056_2 Pyridine nucleotide-disulphide oxidoreductase K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004967 294.0
HKD2_k127_4545056_3 DNA alkylation repair enzyme - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003359 267.0
HKD2_k127_4545056_4 Radical SAM domain protein K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000007616 226.0
HKD2_k127_4545056_5 Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) K03653 - 4.2.99.18 0.00000000000000000000000000000000000000000000000009255 186.0
HKD2_k127_4545056_6 Nitrite and sulphite reductase 4Fe-4S - - - 0.00000000000001726 75.0
HKD2_k127_454743_0 PFAM NHL repeat containing protein - - - 0.0000000000000000005617 103.0
HKD2_k127_454743_1 Subtilase family - - - 0.0000000000000001073 95.0
HKD2_k127_454743_2 helix_turn_helix ASNC type K03719 - - 0.000006619 55.0
HKD2_k127_4561363_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity K01409 GO:0000049,GO:0000408,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.3.1.234 0.0000000000000002721 81.0
HKD2_k127_4561363_1 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.0000006674 61.0
HKD2_k127_4561363_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000001176 60.0
HKD2_k127_4583064_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000001119 225.0
HKD2_k127_4583064_1 Peptidase S8 - - - 0.0000000007749 64.0
HKD2_k127_4621103_0 Putative adhesin - - - 0.00000000000000000008817 98.0
HKD2_k127_4621103_1 PFAM glycosyl hydrolase 53 domain protein K01224 - 3.2.1.89 0.00000000000000004556 92.0
HKD2_k127_4643865_0 translation initiation factor activity K03646 - - 0.0000001355 63.0
HKD2_k127_4643865_1 'Cold-shock' DNA-binding domain K03704 - - 0.0002543 44.0
HKD2_k127_4715711_0 Belongs to the peptidase S8 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004765 354.0
HKD2_k127_4715711_1 Glutamine synthetase K01915 - 6.3.1.2 0.00000000000000000003814 93.0
HKD2_k127_4719284_0 dipeptide transport K02035 - - 1.333e-194 621.0
HKD2_k127_4719284_1 DNA polymerase elongation subunit (Family B) K02319 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000362 475.0
HKD2_k127_4719284_2 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001024 372.0
HKD2_k127_4719284_3 Protein of unknown function DUF72 - - - 0.0000000000000000000000000000000000000000000000000000000000000009442 227.0
HKD2_k127_4719284_4 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K15582 - - 0.00002315 47.0
HKD2_k127_4719284_5 Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules K04483 - - 0.0002154 52.0
HKD2_k127_473819_0 ribosomal protein S15 K02956 - - 0.0000000000000000000000000000000000000000000561 164.0
HKD2_k127_473819_1 PFAM phosphoesterase, RecJ domain protein K07463 - - 0.00000000000000000000005105 104.0
HKD2_k127_4742045_0 cysteine-type endopeptidase activity K08589 GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004198,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.22.37 0.000000005285 67.0
HKD2_k127_4742045_1 Psort location CytoplasmicMembrane, score - - - 0.0001442 49.0
HKD2_k127_4781808_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000003846 153.0
HKD2_k127_4781808_1 Belongs to the UPF0107 family K09128 - - 0.000000000000000000000000000000000000000641 151.0
HKD2_k127_4781808_2 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000008631 111.0
HKD2_k127_4781808_3 secreted hydrolase - - - 0.0000001446 64.0
HKD2_k127_4807694_0 Periplasmic copper-binding protein (NosD) K07218 - - 0.0000000002189 71.0
HKD2_k127_4807694_1 PFAM Radical SAM domain protein - - - 0.0005464 46.0
HKD2_k127_4809540_0 flavodoxin nitric oxide synthase - - - 6.524e-198 623.0
HKD2_k127_4809540_1 PFAM ABC transporter related K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002098 367.0
HKD2_k127_4809540_2 PFAM beta-lactamase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000005819 215.0
HKD2_k127_4809540_3 PKD domain - - - 0.000000000002215 80.0
HKD2_k127_4809540_4 metallopeptidase activity K01193,K01212,K02809,K02810,K03332,K18775,K19668 GO:0003674,GO:0003824,GO:0004553,GO:0004564,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005984,GO:0005985,GO:0005987,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044464,GO:0046352,GO:0071704,GO:1901575 2.7.1.211,3.2.1.26,3.2.1.64,3.2.1.65,3.2.1.80,3.2.1.91 0.000001102 59.0
HKD2_k127_4815749_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1356.0
HKD2_k127_4855520_0 Propeptide_C25 - - - 0.000000000003594 78.0
HKD2_k127_4855732_0 TIGRFAM UbiD family decarboxylase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007209 289.0
HKD2_k127_4855732_1 GHMP kinases C terminal K00869 - 2.7.1.36 0.0000000000000000000000000000000000000000000000000000000000000000000000000004362 265.0
HKD2_k127_4855732_2 tRNA pseudouridine synthase D K06176 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000009081 270.0
HKD2_k127_4855732_3 Protein of unknown function (DUF521) K09123 - - 0.000000000000000000000000000000000000000000000000000000000000001429 222.0
HKD2_k127_4855732_4 - - - - 0.00000000000000001128 86.0
HKD2_k127_4925830_0 Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004522 455.0
HKD2_k127_4925830_1 GTP-binding protein K06883 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000005102 298.0
HKD2_k127_4925830_2 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043021,GO:0043022,GO:0044424,GO:0044464,GO:0044877 - 0.0000000000000000000000000000000000000000000000000000000000000000000008687 252.0
HKD2_k127_4925830_3 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K17884 - 2.7.8.39,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000001738 218.0
HKD2_k127_4925830_4 Putative exonuclease SbcCD, C subunit K03546 - - 0.0000000000000000000000000000000000000000000000007511 181.0
HKD2_k127_4925830_5 Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates K18532 - 2.7.4.3 0.00000000000000000000000000000009678 130.0
HKD2_k127_4925830_6 Uncharacterized protein conserved in archaea (DUF2073) K09743 - - 0.0000000000000000000000000004576 117.0
HKD2_k127_4925830_7 Zn-ribbon containing protein K07163 - - 0.00000000000000047 85.0
HKD2_k127_4925830_8 Domain of unknown function (DUF4430) - - - 0.0004059 52.0
HKD2_k127_4953474_0 Fibronectin-binding protein A N-terminus (FbpA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004829 400.0
HKD2_k127_4953474_1 4Fe-4S single cluster domain K04069 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009 373.0
HKD2_k127_4953474_2 May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity K06965 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000032 276.0
HKD2_k127_4953474_3 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.00000000000000000000000000000000000000000000000000000000000007375 225.0
HKD2_k127_4953474_4 Peptidase family M28 K19701 - 3.4.11.10,3.4.11.6 0.0000000000000000001777 100.0
HKD2_k127_4953474_5 Peptidase C14 caspase catalytic subunit p20 - - - 0.000005293 59.0
HKD2_k127_5035144_0 ABC-type phosphate transport system, periplasmic component K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001228 312.0
HKD2_k127_5050911_0 transferase activity, transferring glycosyl groups K01365,K14475 - 3.4.22.15 0.0000000000000000000000000000000000004996 158.0
HKD2_k127_5050911_1 COG1522 Transcriptional regulators K03719 - - 0.00000005281 59.0
HKD2_k127_5081405_0 Trypsin-like serine protease with C-terminal PDZ domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000314 256.0
HKD2_k127_5105653_0 Carboxypeptidase regulatory-like domain K07151 - 2.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006754 359.0
HKD2_k127_5105653_1 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 305.0
HKD2_k127_5105653_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17104 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 2.5.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000004041 270.0
HKD2_k127_5105653_3 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000008675 267.0
HKD2_k127_5105653_4 PFAM AMMECR1 domain protein K09141 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001275 245.0
HKD2_k127_5105653_5 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0017076,GO:0018130,GO:0019178,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042578,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 0.00000000000000000000000000000000000000000000001074 181.0
HKD2_k127_5105653_6 Putative small multi-drug export protein - - - 0.000000000000000000000000000001237 126.0
HKD2_k127_5105653_7 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.0000000000000000000000001899 108.0
HKD2_k127_5141030_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000002583 232.0
HKD2_k127_5141030_1 PFAM SOUL heme-binding protein - - - 0.00000000000000000000000000000000000000000000004304 175.0
HKD2_k127_5141030_2 - - - - 0.00000007109 57.0
HKD2_k127_5235790_0 Domain of unknown function (DUF362) - - - 0.000000000000000000000000000000000000001472 162.0
HKD2_k127_526025_0 Threonine dehydratase K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007693 385.0
HKD2_k127_526025_1 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 - 2.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002365 278.0
HKD2_k127_526025_2 PFAM Major Facilitator Superfamily - - - 0.00000000000000000036 100.0
HKD2_k127_526025_3 Domain of unknown function (DUF1805) - - - 0.000000000000000006789 87.0
HKD2_k127_5331126_0 toxin activity - - - 0.00000000000002053 83.0
HKD2_k127_5331126_1 cell wall organization K01448 - 3.5.1.28 0.00000000001377 79.0
HKD2_k127_5331126_2 Lamin Tail Domain - - - 0.000002544 61.0
HKD2_k127_5356243_0 PFAM amidohydrolase K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000008953 246.0
HKD2_k127_5369478_0 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002068 388.0
HKD2_k127_5398643_0 Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates K06863 - 6.3.4.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 492.0
HKD2_k127_5398643_1 Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA K04799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006295 364.0
HKD2_k127_5398643_2 aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 330.0
HKD2_k127_5398643_3 PFAM HhH-GPD superfamily base excision DNA repair protein K10773 - 4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000001075 245.0
HKD2_k127_5398643_4 Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA K14568 GO:0000154,GO:0000462,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019843,GO:0022613,GO:0030490,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070037,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.260 0.0000000000000000000000000000000000000000000000000000000000007382 217.0
HKD2_k127_5398643_5 Winged helix DNA-binding domain (DUF1495) K09745 - - 0.0000000000000000000001015 102.0
HKD2_k127_540043_0 Carbamoyl-phosphate synthetase large chain domain protein K01961,K01968,K11263 - 6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000527 274.0
HKD2_k127_540043_1 PFAM carboxyl transferase K01969,K15052 - 2.1.3.15,6.4.1.3,6.4.1.4 0.000000000000000003367 87.0
HKD2_k127_540043_2 Biotin carboxylase C-terminal domain K01968 - 6.4.1.4 0.0000000000000008652 85.0
HKD2_k127_5432556_0 FAD linked oxidase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004808 372.0
HKD2_k127_5432556_1 Protein of unknown function (DUF3887) K06889 GO:0003674,GO:0003824,GO:0016787,GO:0016788,GO:0052689 - 0.0004458 49.0
HKD2_k127_5433712_0 3-Oxoacyl- acyl-carrier-protein (ACP) synthase III C terminal K01641 - 2.3.3.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003234 274.0
HKD2_k127_5433712_1 archaeal coiled-coil protein - - - 0.0000000000000000000000003974 116.0
HKD2_k127_5445405_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003215 285.0
HKD2_k127_5445405_1 PFAM Fibronectin type III domain - - - 0.000000000000000000000000000000000000000001593 175.0
HKD2_k127_5445405_2 helicase activity - - - 0.000000000000000000000000002537 116.0
HKD2_k127_5445405_3 guanyl-nucleotide exchange factor activity K01179,K03929,K09612,K12287,K19701,K19702 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.2.1.4,3.4.11.10,3.4.11.24,3.4.11.6 0.0000000000000000000002669 112.0
HKD2_k127_5454140_0 Thymidylate kinase K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.000000000000000003337 89.0
HKD2_k127_5461002_0 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 556.0
HKD2_k127_5461002_1 TIGRFAM RNA methyltransferase, TrmH family, group 1 K02533 - - 0.000000000000000000000000000000000000000000000000000000006356 207.0
HKD2_k127_5461002_2 Predicted membrane protein (DUF2085) - - - 0.0000000000000000000000000006039 121.0
HKD2_k127_5461002_3 Belongs to the eukaryotic ribosomal protein eL40 family K02927 - - 0.0000000000001318 71.0
HKD2_k127_5498419_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 597.0
HKD2_k127_5498419_1 Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs K03177,K11131 - 5.4.99.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 359.0
HKD2_k127_5498419_2 NYN domain - - - 0.00000000000000000000000000000000000000000000000000000000000000008361 225.0
HKD2_k127_5498419_3 Ribosomal protein L11 methyltransferase (PrmA) K07579 - - 0.0000000000000000000000000000000000000000000000000004861 190.0
HKD2_k127_5498419_4 Belongs to the archaeal adenylate kinase family K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000576 188.0
HKD2_k127_5498419_5 Belongs to the cytidylate kinase family. Type 2 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000003664 173.0
HKD2_k127_5498419_6 Integral membrane protein DUF106 - - - 0.0000000000000000000000001491 115.0
HKD2_k127_5498419_7 Binds to the 23S rRNA K02876 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000003729 106.0
HKD2_k127_5498419_8 - - - - 0.000000000000008397 83.0
HKD2_k127_552046_0 phosphoenolpyruvate carboxykinase (GTP) activity K01596,K01610 - 4.1.1.32,4.1.1.49 1.941e-241 761.0
HKD2_k127_552046_1 Nitroreductase family - - - 0.0004566 43.0
HKD2_k127_5521209_0 PFAM Peptidase C1A, papain - - - 0.00000000000000000004685 105.0
HKD2_k127_5521209_1 periplasmic copper-binding protein NosD K07218 - - 0.0000005414 61.0
HKD2_k127_5541171_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007266 474.0
HKD2_k127_5541171_1 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000018 143.0
HKD2_k127_5541171_2 Belongs to the ABC transporter superfamily K10823 - - 0.00000000000000000001587 92.0
HKD2_k127_5582300_0 Papain family cysteine protease - - - 0.000000000000000000000000000008122 134.0
HKD2_k127_5582300_1 carboxylic ester hydrolase activity - - - 0.0000000000000000003062 98.0
HKD2_k127_5582300_2 Peptidase family C25 - - - 0.0000000002097 74.0
HKD2_k127_5602832_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03237 GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002093 293.0
HKD2_k127_5602832_1 PAC2 family K07159 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000455 254.0
HKD2_k127_5602832_2 Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange K04484 - - 0.00000000000000000000000000000000000000000000001797 178.0
HKD2_k127_5602832_3 Binds to the 23S rRNA K02929 - - 0.0000000000000000000000000000000000004451 143.0
HKD2_k127_5602832_4 Diphthamide K07561 - 2.5.1.108 0.000000000000000000000000002218 115.0
HKD2_k127_5602832_5 PFAM Ribosomal protein S27E K02978 - - 0.00000000000000009005 81.0
HKD2_k127_5602832_6 protein conserved in archaea K09723 - - 0.0000000008048 67.0
HKD2_k127_5602832_7 more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA K11130 - - 0.000000002365 59.0
HKD2_k127_5616125_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823,K03918 - 2.6.1.19,2.6.1.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 537.0
HKD2_k127_5616125_1 Catalyzes the attachment of glycine to tRNA(Gly) K01880 GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 540.0
HKD2_k127_5616125_2 Sugar isomerase (SIS) K15916 - 5.3.1.8,5.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000007132 261.0
HKD2_k127_5616125_3 PFAM CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000003904 224.0
HKD2_k127_5616125_4 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000001072 187.0
HKD2_k127_5634091_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 2.205e-196 621.0
HKD2_k127_5634091_1 Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends K03537 - 3.1.26.5 0.000002281 53.0
HKD2_k127_5650687_0 FAD linked oxidase domain protein - - - 0.0000000000000000000000000001484 125.0
HKD2_k127_5650687_1 PFAM Peptidase C1A, papain - - - 0.00000000000003479 85.0
HKD2_k127_5656252_0 Arylsulfotransferase (ASST) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001697 353.0
HKD2_k127_5656252_1 PFAM NHL repeat containing protein - - - 0.000001211 56.0
HKD2_k127_5671877_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008442 341.0
HKD2_k127_5671877_1 Lipoate-protein ligase K03800 - 6.3.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007176 312.0
HKD2_k127_5671877_2 4Fe-4S single cluster domain K04070 - 1.97.1.4 0.000000000000000000000000000000000000000000000001121 178.0
HKD2_k127_5671877_3 Membrane protein of unknown function DUF63 - - - 0.0000000001942 68.0
HKD2_k127_5671877_4 PFAM biotin lipoate A B protein ligase - - - 0.0000000002221 66.0
HKD2_k127_5701356_0 ATP-NAD AcoX kinase K00858 - 2.7.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008075 313.0
HKD2_k127_5701356_1 PFAM Aminotransferase class I and II K00639,K00652 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 0.0000000000000000000000000000000000000000000000005455 182.0
HKD2_k127_5722418_0 Arylsulfotransferase (ASST) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004096 341.0
HKD2_k127_5722418_1 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008444 265.0
HKD2_k127_5722418_2 PFAM flavin reductase domain protein, FMN-binding - - - 0.000000000000000000000000000000000000000000000000000000000006218 211.0
HKD2_k127_5722418_3 Flavodoxin - GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000006208 201.0
HKD2_k127_5722418_4 glucosylceramidase activity - - - 0.0000000000000000000000000002434 118.0
HKD2_k127_5722418_5 - - - - 0.000000000000000000000000105 109.0
HKD2_k127_5722418_6 Arylsulfotransferase (ASST) - - - 0.000000000003233 75.0
HKD2_k127_5722418_7 TfoX N-terminal domain - - - 0.000000000008799 69.0
HKD2_k127_5722418_8 Acetyltransferase (GNAT) domain - - - 0.00000006879 60.0
HKD2_k127_5774005_0 DHHA1 domain K07463 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 466.0
HKD2_k127_5774005_1 Uncharacterised conserved protein (DUF2156) K01163 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005998 270.0
HKD2_k127_5774005_2 Belongs to the arginase family K01480 - 3.5.3.11 0.00000000000000000000000000000000000000000000000000000000000000000001627 242.0
HKD2_k127_5774005_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000005978 178.0
HKD2_k127_5774005_4 Functions by promoting the formation of the first peptide bond K03263 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000001296 172.0
HKD2_k127_5774005_5 dihydromethanopterin reductase activity K00176,K06411,K12527 - 1.2.7.3,1.97.1.9 0.0000000000000005346 81.0
HKD2_k127_5774005_6 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03775 - 5.2.1.8 0.0002662 53.0
HKD2_k127_5779083_0 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.000000000000000000000000000000000000000001903 159.0
HKD2_k127_5779083_1 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000001089 154.0
HKD2_k127_5779083_2 Belongs to the eukaryotic ribosomal protein eL18 family K02883 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000001957 145.0
HKD2_k127_5779083_3 Protein of unknown function (DUF1211) - - - 0.00000000000000000000000000000000001301 143.0
HKD2_k127_5779083_4 UbiA prenyltransferase family K03179 - 2.5.1.39 0.00000000000000000002984 92.0
HKD2_k127_5779083_5 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03058 - 2.7.7.6 0.0000000000000000004082 88.0
HKD2_k127_5779083_6 helix_turn_helix, Arsenical Resistance Operon Repressor - GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - 0.000000000000000001507 94.0
HKD2_k127_5779083_7 COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component K01992 - - 0.000001062 55.0
HKD2_k127_5781516_0 tRNA binding K04566 - 6.1.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008839 504.0
HKD2_k127_5781516_1 Belongs to the purine pyrimidine phosphoribosyltransferase family K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000008968 206.0
HKD2_k127_5781516_2 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.000000000000000000000002735 112.0
HKD2_k127_5781516_3 TIGRFAM RNA modification enzyme, MiaB family K15865 - 2.8.4.5 0.000000000007308 68.0
HKD2_k127_5781516_4 but it may be involved in stabilization of the trimeric complex - - - 0.0000009868 53.0
HKD2_k127_5783875_0 Carbamoyl-phosphate synthetase ammonia chain K01955 - 6.3.5.5 0.0 1560.0
HKD2_k127_5783875_1 Belongs to the CarA family K01955,K01956 GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 523.0
HKD2_k127_5783875_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004876 381.0
HKD2_k127_5783875_3 PFAM RNA-metabolising metallo-beta-lactamase K12574 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 361.0
HKD2_k127_5783875_4 PFAM HD domain K03698 - - 0.00000000000000000000000000000000000000000000000000000000001191 220.0
HKD2_k127_5783875_5 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000005663 123.0
HKD2_k127_5783875_6 Peptidase A24A, prepilin type IV K07991 - 3.4.23.52 0.0000000000000000001976 95.0
HKD2_k127_5783875_7 Belongs to the UPF0434 family - - - 0.0000000000000002334 80.0
HKD2_k127_5783875_8 polysaccharide catabolic process K01179 - 3.2.1.4 0.00000001652 56.0
HKD2_k127_5784520_0 - - - - 0.000000000000000000000000000000000000000000000000000000006075 203.0
HKD2_k127_5784520_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.000000000000000000000000000000000000000002472 159.0
HKD2_k127_5787959_0 amino acid activation for nonribosomal peptide biosynthetic process K17713,K20952 - - 0.0000000000000001331 94.0
HKD2_k127_5791401_0 Aconitase family (aconitate hydratase) K01703,K01704,K01705 - 4.2.1.33,4.2.1.35,4.2.1.36 8.044e-236 746.0
HKD2_k127_5791401_1 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000701 261.0
HKD2_k127_5814492_0 PFAM regulatory protein, ArsR - - - 0.000000000000000005673 93.0
HKD2_k127_5814492_1 Domain of unknown function (DUF1610) K07580 - - 0.0000000000000004459 80.0
HKD2_k127_5814492_2 Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA K03232 - - 0.0000000000003038 72.0
HKD2_k127_5814492_3 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.0006215 44.0
HKD2_k127_5826335_0 DUF35 OB-fold domain, acyl-CoA-associated K07068 - - 0.000000000000000000000000000000000000000000004699 167.0
HKD2_k127_5826335_1 PFAM Thiolase K00626 - 2.3.1.9 0.000000000000000000000000000000000000003132 147.0
HKD2_k127_5826335_2 Protein of unknown function (DUF1614) - - - 0.00000000000000000005992 98.0
HKD2_k127_5830466_0 Carbamoyl-phosphate synthetase large chain domain protein K01959 - 6.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 563.0
HKD2_k127_5830466_1 TIGRFAM Oxaloacetate decarboxylase, alpha subunit K01960 - 6.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 534.0
HKD2_k127_5830466_2 biotin lipoate A B protein ligase K03524 - 6.3.4.15 0.0000000000000000000000000000000000000000000000000000126 198.0
HKD2_k127_5830466_3 Putative redox-active protein (C_GCAxxG_C_C) - - - 0.00000000000000000000000002606 112.0
HKD2_k127_5830466_4 conserved protein, contains double-stranded beta-helix domain - - - 0.00000000000000000007224 93.0
HKD2_k127_5837107_0 Belongs to the SOS response-associated peptidase family - - - 0.00000000000000000000000000000000000000000000000000000002481 202.0
HKD2_k127_5837107_1 COG1520 FOG WD40-like repeat - - - 0.0000000000000000008953 100.0
HKD2_k127_5841423_0 Metallo-beta-lactamase superfamily K06167 - 3.1.4.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004335 304.0
HKD2_k127_5841423_1 D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo K09716 - 3.1.1.96 0.0000000000000000000000000000000000000000000000000000000003845 213.0
HKD2_k127_5841423_2 4Fe-4S single cluster domain K04070 - 1.97.1.4 0.00000000000000000000000000000000000000000005777 166.0
HKD2_k127_5841423_3 6-O-methylguanine DNA methyltransferase, DNA binding domain K05982 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.21.7 0.00000000000000000000000000001864 121.0
HKD2_k127_5841423_4 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K18824 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 0.00000000000000002564 83.0
HKD2_k127_5853038_0 Protein of unknown function (DUF1616) - - - 0.00000000000000000000000000000000000000000000000000000000000002984 223.0
HKD2_k127_5853038_1 metallopeptidase activity - - - 0.0000000000000000003033 102.0
HKD2_k127_5871822_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000188 205.0
HKD2_k127_5871822_1 Archaeal holliday junction resolvase (hjc) - - - 0.00000000000000000000000000000000000000000000029 174.0
HKD2_k127_5871822_2 PFAM CBS domain containing protein - - - 0.000000000000000000000000000004911 125.0
HKD2_k127_5871822_3 AMP binding - - - 0.000000000000008559 79.0
HKD2_k127_5890873_0 PFAM Methionine synthase, vitamin-B12 independent K00549 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 0.0000000000000000000000000000005453 129.0
HKD2_k127_5890873_1 COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins K07466 - - 0.00000000002995 70.0
HKD2_k127_5890873_2 thymidylate synthase K00560 - 2.1.1.45 0.00000007956 58.0
HKD2_k127_5893050_0 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000005723 214.0
HKD2_k127_5893050_1 dUTPase K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000007217 164.0
HKD2_k127_5893050_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.000000000000000000000000000000002471 138.0
HKD2_k127_5893050_3 domain protein K20276 - - 0.000000005655 69.0
HKD2_k127_5893835_0 CorA-like Mg2+ transporter protein K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007211 295.0
HKD2_k127_5893835_1 KaiC - - - 0.000000000000000000000000001101 122.0
HKD2_k127_5893835_2 Circadian clock protein KaiC - - - 0.000000000000000000002623 104.0
HKD2_k127_5893835_3 methyltransferase activity - - - 0.00000000000007867 78.0
HKD2_k127_5928566_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000001843 222.0
HKD2_k127_5928566_1 Peptidase family M28 K05994 - 3.4.11.10 0.000000000000000000000000008553 125.0
HKD2_k127_5928566_2 UbiA prenyltransferase family K20616 - - 0.000000000000000000000656 104.0
HKD2_k127_5928566_3 - - - - 0.000000000000000001068 89.0
HKD2_k127_5964556_0 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000773 156.0
HKD2_k127_5964556_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K05996,K07752 - 3.4.17.18,3.4.17.22 0.0000000000000000000000000000000000000001309 168.0
HKD2_k127_5964556_2 Winged helix-turn-helix domain (DUF2582) - - - 0.0000005678 57.0
HKD2_k127_5964556_3 Winged helix-turn-helix domain (DUF2582) - - - 0.000001436 56.0
HKD2_k127_597695_0 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001791 268.0
HKD2_k127_597695_1 Binds directly to 23S rRNA. Probably involved in E site tRNA release K02863 GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000006991 242.0
HKD2_k127_597695_2 HTH-type transcriptional regulatory protein K07728 - - 0.0000000001991 64.0
HKD2_k127_5982445_0 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 - 4.1.99.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002534 430.0
HKD2_k127_5982445_1 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02323 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000571 379.0
HKD2_k127_5982445_2 Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase K02322 GO:0003674,GO:0005488,GO:0005515,GO:0042802 2.7.7.7 0.00000000000000000000000000000007171 129.0
HKD2_k127_6020018_0 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000000000000000000000000000000000000000000003304 218.0
HKD2_k127_6020018_1 Peptidase family M20/M25/M40 K01270 - - 0.000000000000000000000303 96.0
HKD2_k127_6042497_0 peptidyl-lysine modification to peptidyl-hypusine K00809 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.5.1.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 448.0
HKD2_k127_6042497_1 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007847 364.0
HKD2_k127_6042497_2 PFAM PP-loop domain protein K06864 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 321.0
HKD2_k127_6042497_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001576 260.0
HKD2_k127_6042497_4 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.00000000000000000000000000000000000000000000000000000000000000007012 230.0
HKD2_k127_6042497_5 Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups K00555 GO:0001510,GO:0002940,GO:0003674,GO:0003824,GO:0004809,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.215,2.1.1.216 0.00000000000000000000000000000000000000000000000000000000001718 216.0
HKD2_k127_6042497_6 SelR domain K07305 - 1.8.4.12 0.000000000000000000000000000000000000000000000000000002248 194.0
HKD2_k127_6042497_7 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.0000000000000000000000000000000000007883 143.0
HKD2_k127_6042497_8 COG1691 NCAIR mutase (PurE)-related K06898 - - 0.0000000000000003553 81.0
HKD2_k127_6042497_9 - - - - 0.000001297 57.0
HKD2_k127_6059444_0 ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter K01531 - 3.6.3.2 3.052e-267 848.0
HKD2_k127_6059444_1 Pyridine nucleotide-disulphide oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000001802 211.0
HKD2_k127_6059444_2 PFAM UbiA prenyltransferase K02548 - 2.5.1.74 0.00000000000000000000000000000000000000000000000000005846 198.0
HKD2_k127_6059444_3 TIGRFAM geranylgeranyl reductase - - - 0.00000000000000000000000000000000000000001705 168.0
HKD2_k127_6059444_4 VIT family - - - 0.000000000000000000000000000008086 129.0
HKD2_k127_6059444_5 TIGRFAM geranylgeranyl reductase - - - 0.000000000000000000000002592 110.0
HKD2_k127_6059444_6 UbiA prenyltransferase family K02548 - 2.5.1.74 0.000000000000000000001623 99.0
HKD2_k127_6059444_7 - - - - 0.000000000000007839 86.0
HKD2_k127_6084734_0 Tellurite resistance protein TehB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000408 392.0
HKD2_k127_6084734_1 Arylsulfotransferase (ASST) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001939 276.0
HKD2_k127_6084734_2 by modhmm K03655 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000004477 251.0
HKD2_k127_6098686_0 Male sterility protein - - - 0.0000000000000000000000000004292 118.0
HKD2_k127_6098686_1 PFAM Transglutaminase-like - - - 0.0004576 51.0
HKD2_k127_6111830_0 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 372.0
HKD2_k127_6111830_1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 0.000000000000000000000000000000000000000000000000000006318 192.0
HKD2_k127_6119953_0 amp-dependent synthetase and ligase - - - 0.0000002756 63.0
HKD2_k127_61368_0 by modhmm - - - 0.0000000000000000000000000000000000000766 158.0
HKD2_k127_6166803_0 Belongs to the TPP enzyme family - - - 0.00000000001773 75.0
HKD2_k127_6189273_0 helicase activity - - - 7.126e-255 799.0
HKD2_k127_6189273_1 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 GO:0001510,GO:0002128,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.206 0.000000000000000000000000000000000000000000000000000000004087 203.0
HKD2_k127_6189273_2 Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs K07254 - 2.1.1.206 0.00000000000000000000000000000000000000000008252 165.0
HKD2_k127_6189273_3 FG-GAP repeat - - - 0.0000001332 55.0
HKD2_k127_6189273_4 membrane-associated protein domain - - - 0.0000004096 63.0
HKD2_k127_6212596_0 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 GO:0003674,GO:0003824,GO:0003963,GO:0009975,GO:0016874,GO:0016886,GO:0140098 6.5.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002252 276.0
HKD2_k127_6212596_1 Belongs to the CinA family K03742 - 3.5.1.42 0.0000000000000000000000000000000000000000003982 163.0
HKD2_k127_6251501_0 Belongs to the peptidase S16 family K04076 - 3.4.21.53 7.058e-255 803.0
HKD2_k127_6251501_1 Cytidylyltransferase-like K00952 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.7.1 0.0000000000000000000000000000000000000000000000000000001842 199.0
HKD2_k127_6251501_2 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K04040,K13605 - 2.5.1.133,2.5.1.62 0.00001954 56.0
HKD2_k127_6251501_3 Polymer-forming cytoskeletal - - - 0.00007814 47.0
HKD2_k127_6267778_0 B12 binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009805 300.0
HKD2_k127_6267778_1 coenzyme F390 K01912 - 6.2.1.30 0.0000000000000000000000000000000005474 147.0
HKD2_k127_6267778_2 4Fe-4S binding domain - - - 0.00000000000000000000004563 102.0
HKD2_k127_6274705_0 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K03231 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004176 601.0
HKD2_k127_6274705_1 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000007812 164.0
HKD2_k127_6274705_2 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K15778 - 5.4.2.2,5.4.2.8 0.0005948 42.0
HKD2_k127_6325324_0 Trypsin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 293.0
HKD2_k127_6325324_1 Domain of unknown function (DUF362) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005939 261.0
HKD2_k127_6325324_2 Metallo-beta-lactamase superfamily - - - 0.000002602 49.0
HKD2_k127_6362423_0 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000000001114 233.0
HKD2_k127_6362423_1 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000696 93.0
HKD2_k127_6419595_0 Belongs to the peptidase S8 family K20276 - - 0.0000000000004 83.0
HKD2_k127_6419595_1 pectinesterase activity K01051,K10297 - 3.1.1.11 0.0002769 49.0
HKD2_k127_6447436_0 agmatine deiminase activity K10536 - 3.5.3.12 0.0000000000000000000002218 107.0
HKD2_k127_6447436_1 UbiA prenyltransferase family K17105 - 2.5.1.42 0.000000000000000002882 90.0
HKD2_k127_6447436_2 Domain of unknown function (DUF4314) - - - 0.00000002245 57.0
HKD2_k127_6449129_0 SMART Peptidase A22, presenilin signal peptide - - - 0.00000000000000000000000000000000000000000000000000000007367 207.0
HKD2_k127_6449129_1 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction K03147 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 0.000000000000000000000000000000000006831 138.0
HKD2_k127_6449129_2 Rhomboid family - - - 0.000000000000000000000001085 113.0
HKD2_k127_6449129_3 peptidase activity, acting on L-amino acid peptides K07004,K09955 - - 0.00000000001924 76.0
HKD2_k127_6449129_4 domain, Protein - - - 0.00001009 58.0
HKD2_k127_646076_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K03234 - - 9.145e-254 794.0
HKD2_k127_646076_1 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center K02992 GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000001414 229.0
HKD2_k127_646076_2 With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits K02950 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000000887 218.0
HKD2_k127_6474369_0 COG0058 Glucan phosphorylase - - - 3.329e-223 705.0
HKD2_k127_6474369_1 Glycogen debranching enzyme N terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003569 391.0
HKD2_k127_6474369_2 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001411 370.0
HKD2_k127_6474369_3 Peptidase family C25 - - - 0.0000000007284 70.0
HKD2_k127_6474369_4 helix_turn_helix ASNC type - - - 0.00000001655 66.0
HKD2_k127_6518898_0 Evidence 5 No homology to any previously reported sequences - - - 0.0000000000000000000000000000000000000000000000000000000000003283 237.0
HKD2_k127_6518898_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K05996,K06987,K07752 - 3.4.17.18,3.4.17.22 0.0000000000000000000000000000000000000000000000000000000002648 227.0
HKD2_k127_6518898_2 Belongs to the peptidase S8 family K13276,K17734 - - 0.00000001717 66.0
HKD2_k127_6520337_0 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003703 487.0
HKD2_k127_6520337_1 Metal dependent phosphohydrolases with conserved 'HD' motif. K06885 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008064 357.0
HKD2_k127_6520337_2 Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea K00096 - 1.1.1.261 0.000000000000000000000000000000000000000000000000000000004914 202.0
HKD2_k127_6520337_3 Thioredoxin K03671 - - 0.00000000000000000000000000000000000000003567 155.0
HKD2_k127_6520337_4 Belongs to the carbohydrate kinase PfkB family K00852 - 2.7.1.15 0.00000000000000000000000000000000007301 146.0
HKD2_k127_6520337_5 Uncharacterised protein family (UPF0179) K09730 - - 0.000000000000000000000000000000000816 135.0
HKD2_k127_6520337_6 - - - - 0.0000000000000000000000006366 108.0
HKD2_k127_6536886_0 PP-loop family K21947 - 2.8.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008958 309.0
HKD2_k127_6536886_1 Rad51 - - - 0.000000000000000000000000000000000000000000000000000000000000000000005433 242.0
HKD2_k127_6536886_2 PFAM fumarylacetoacetate (FAA) hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000003391 232.0
HKD2_k127_6536886_3 Pfam:KaiC - - - 0.00000000000000000000000000000001924 136.0
HKD2_k127_6536886_4 COG0467 RecA-superfamily ATPases implicated in signal transduction - - - 0.00001009 55.0
HKD2_k127_655252_0 Sulfotransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005457 248.0
HKD2_k127_655252_1 Glycosyl transferase family 21 - - - 0.0000000000000000000000000000000000000005446 163.0
HKD2_k127_6579747_0 Parallel beta-helix repeats - - - 0.00002157 56.0
HKD2_k127_6582613_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003405 554.0
HKD2_k127_6582613_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 340.0
HKD2_k127_6582613_2 PFAM helix-turn-helix HxlR type - - - 0.00001035 48.0
HKD2_k127_6585436_0 Methylase involved in ubiquinone menaquinone biosynthesis - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003092 263.0
HKD2_k127_6585436_1 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.000000000000000000000000000000000000000000000000000000000000001193 229.0
HKD2_k127_6585436_2 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000001554 220.0
HKD2_k127_6585436_3 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000135 205.0
HKD2_k127_6585436_4 PFAM helix-turn-helix HxlR type - - - 0.0000000000000000000000000000000000000008748 150.0
HKD2_k127_6585436_5 - - - - 0.0000000000000000000000000000000000148 143.0
HKD2_k127_6585436_6 Papain family cysteine protease - - - 0.000000000000000000000004736 117.0
HKD2_k127_6594751_0 agmatine deiminase activity K10536 - 3.5.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005576 311.0
HKD2_k127_6595218_0 PFAM NHL repeat containing protein - - - 0.000000000003887 77.0
HKD2_k127_6595218_1 Domain of unknown function (DUF4389) - - - 0.00000232 59.0
HKD2_k127_6595218_2 protein conserved in archaea - - - 0.000005631 58.0
HKD2_k127_6621186_0 Cys/Met metabolism PLP-dependent enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002203 374.0
HKD2_k127_6621186_1 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000002993 140.0
HKD2_k127_6717960_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K17870 - 1.6.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000247 297.0
HKD2_k127_6717960_1 Calcineurin-like phosphoesterase superfamily domain K03547 - - 0.0000000000000000000000000005092 116.0
HKD2_k127_6749183_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.000000000000000000000000000000000000000000005366 173.0
HKD2_k127_6749183_1 Protein of unknown function, DUF485 - - - 0.00000000000000000000000000005581 119.0
HKD2_k127_6789414_0 PFAM sodium hydrogen exchanger - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009652 425.0
HKD2_k127_6789414_1 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.0000000000000000000001808 98.0
HKD2_k127_6791910_0 Aldolase/RraA K13831 - 4.1.2.43,5.3.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003606 512.0
HKD2_k127_6791910_1 Major Facilitator Superfamily K08177 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007793 364.0
HKD2_k127_6791910_2 4Fe-4S ferredoxin iron-sulfur binding domain protein K07138 - - 0.000000000000000000000000000000000000000000000002262 186.0
HKD2_k127_6791910_3 Belongs to the UPF0178 family - - - 0.0000000000000000000000000000000000000000005136 160.0
HKD2_k127_6805653_0 Peptidase family M50 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 296.0
HKD2_k127_6805653_1 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.00000000000000000000000000003464 127.0
HKD2_k127_6805653_2 - - - - 0.0000000000000001049 82.0
HKD2_k127_6805653_3 Flagellin is the subunit protein which polymerizes to form the filaments of archaeal flagella K07325 GO:0005575,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - 0.000000001533 68.0
HKD2_k127_6805653_4 N-terminal 7TM region of histidine kinase - - - 0.00000643 59.0
HKD2_k127_6805653_5 CAP_GLY K10421,K10422,K10423 GO:0000226,GO:0000278,GO:0000775,GO:0000776,GO:0001578,GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005694,GO:0005737,GO:0005768,GO:0005794,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005856,GO:0005874,GO:0005875,GO:0005876,GO:0005881,GO:0005882,GO:0006810,GO:0006886,GO:0006996,GO:0007010,GO:0007017,GO:0007026,GO:0007049,GO:0007275,GO:0007349,GO:0007399,GO:0008017,GO:0008092,GO:0008104,GO:0008150,GO:0008270,GO:0009653,GO:0009987,GO:0010638,GO:0010639,GO:0010720,GO:0010975,GO:0010976,GO:0012505,GO:0015031,GO:0015630,GO:0015631,GO:0015833,GO:0016043,GO:0017022,GO:0022008,GO:0030141,GO:0030154,GO:0030424,GO:0030425,GO:0030426,GO:0030427,GO:0031110,GO:0031111,GO:0031112,GO:0031113,GO:0031114,GO:0031116,GO:0031334,GO:0031344,GO:0031346,GO:0031410,GO:0031967,GO:0031975,GO:0031982,GO:0032036,GO:0032271,GO:0032273,GO:0032501,GO:0032502,GO:0032594,GO:0032596,GO:0032886,GO:0032991,GO:0033036,GO:0033043,GO:0033267,GO:0034613,GO:0035371,GO:0036477,GO:0042599,GO:0042802,GO:0042803,GO:0042886,GO:0042995,GO:0043005,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043242,GO:0043244,GO:0043254,GO:0044087,GO:0044089,GO:0044295,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0044860,GO:0044861,GO:0045111,GO:0045169,GO:0045184,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0046872,GO:0046907,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048646,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050773,GO:0050789,GO:0050793,GO:0050794,GO:0051010,GO:0051094,GO:0051128,GO:0051129,GO:0051130,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051493,GO:0051494,GO:0051495,GO:0051641,GO:0051649,GO:0051668,GO:0051960,GO:0051962,GO:0060284,GO:0061024,GO:0065007,GO:0070507,GO:0070727,GO:0070853,GO:0070854,GO:0071702,GO:0071705,GO:0071840,GO:0072657,GO:0090150,GO:0097447,GO:0097458,GO:0097708,GO:0098687,GO:0099080,GO:0099081,GO:0099503,GO:0099512,GO:0099513,GO:0120025,GO:0120035,GO:0120038,GO:0150034,GO:1900006,GO:1901588,GO:1901879,GO:1901880,GO:1902903,GO:1902904,GO:1902905,GO:1903044,GO:1990752,GO:1990778,GO:2000026 - 0.0002018 55.0
HKD2_k127_6809089_0 Peptidase family C25 - - - 0.00000000000001151 83.0
HKD2_k127_681428_0 resolution of meiotic recombination intermediates - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003834 477.0
HKD2_k127_681428_1 Alanine dehydrogenase/PNT, N-terminal domain K00290,K14157 - 1.5.1.7,1.5.1.8,1.5.1.9 0.0000000000000000000000000000000007285 133.0
HKD2_k127_681428_2 Domain of unknown function DUF83 K07464 - 3.1.12.1 0.00000000000000000006941 95.0
HKD2_k127_6823540_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002541 535.0
HKD2_k127_6823540_1 COG1549 Queuine tRNA-ribosyltransferases, contain PUA domain K07557 - 2.6.1.97 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002834 338.0
HKD2_k127_6823540_10 Belongs to the eukaryotic ribosomal protein eL32 family K02912 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.000000000000000000000000000000000004054 145.0
HKD2_k127_6823540_11 - - - - 0.00000000000000000000000000000002015 136.0
HKD2_k127_6823540_12 Peptidase family M50 - - - 0.000000000000000000000000000008828 127.0
HKD2_k127_6823540_13 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03055 - 2.7.7.6 0.00000000000000005249 82.0
HKD2_k127_6823540_14 Pectate lyase - - - 0.00000000431 70.0
HKD2_k127_6823540_2 With S4 and S12 plays an important role in translational accuracy K02988 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 297.0
HKD2_k127_6823540_3 TIGRFAM TraB family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000014 294.0
HKD2_k127_6823540_4 Belongs to the universal ribosomal protein uS2 family K02967 GO:0000028,GO:0000447,GO:0000460,GO:0000461,GO:0000462,GO:0000466,GO:0000469,GO:0000478,GO:0000479,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0031123,GO:0031125,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001161 261.0
HKD2_k127_6823540_5 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000008536 194.0
HKD2_k127_6823540_6 Ribosomal protein L30p/L7e K02907 GO:0000463,GO:0000470,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000001328 178.0
HKD2_k127_6823540_7 binds to the 23S rRNA K02885 GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000003428 168.0
HKD2_k127_6823540_8 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000006497 168.0
HKD2_k127_6823540_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000000000000000000007381 152.0
HKD2_k127_6901936_0 Desulfoferrodoxin ferrous iron-binding domain K05919 - 1.15.1.2 0.00000000000000000000000000000000000000000000000000002768 190.0
HKD2_k127_6901936_1 NifU-like N terminal domain K04488 - - 0.0000000000000000000000000000000000008512 139.0
HKD2_k127_6901936_2 protein conserved in archaea - - - 0.00000000000000000004086 93.0
HKD2_k127_6901936_3 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.00000000167 69.0
HKD2_k127_6904642_0 eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA K03242 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 446.0
HKD2_k127_6904642_1 DNA-directed RNA polymerase K03049 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000003555 216.0
HKD2_k127_6904642_2 Belongs to the eukaryotic ribosomal protein eS6 family K02991 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360,GO:1990904 - 0.0000000000000000000000000000000000000000000001279 171.0
HKD2_k127_6904642_3 Belongs to the UPF0218 family K09735 - - 0.00000000000000000000003654 111.0
HKD2_k127_6904642_4 Belongs to the eukaryotic ribosomal protein eS31 family K02977 - - 0.00000000000000001429 83.0
HKD2_k127_6904642_5 Belongs to the eukaryotic ribosomal protein eS24 family K02974 - - 0.00000000000000001612 86.0
HKD2_k127_6904642_6 Transcription elongation factor Spt4 K03050 - 2.7.7.6 0.0000000000001855 71.0
HKD2_k127_6909354_0 PFAM Peptidase C1A, papain - - - 0.00001442 55.0
HKD2_k127_6911547_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007235 246.0
HKD2_k127_6911547_1 methylated-DNA-[protein]-cysteine S-methyltransferase activity K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000001332 207.0
HKD2_k127_6911547_2 RibD C-terminal domain K14654 - 1.1.1.302 0.0000000000000000000000000000000000000000000000000000000004528 208.0
HKD2_k127_6911547_3 Protein of unknown function (DUF3795) - - - 0.0000000000001833 76.0
HKD2_k127_6911547_4 Protein of unknown function (DUF3795) - - - 0.000000001762 58.0
HKD2_k127_6913470_0 Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs K18779 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005494 373.0
HKD2_k127_6913470_1 PFAM Pre-mRNA processing ribonucleoprotein, binding K14564 - - 0.000000000000000000000000000000000000004247 154.0
HKD2_k127_6923135_0 Beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000008337 236.0
HKD2_k127_6923135_1 Resolvase, N terminal domain - - - 0.000000000000000004418 86.0
HKD2_k127_6948022_0 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000003782 218.0
HKD2_k127_6984006_0 Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K18882 - - 0.0000000000000000000000000000000000000000000000000000000000000003839 232.0
HKD2_k127_6984006_1 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.000000499 52.0
HKD2_k127_6988002_0 PFAM glycosyl transferase group 1 K13057 - 2.4.1.245 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003733 524.0
HKD2_k127_6988002_1 Xylose isomerase-like TIM barrel K01151 - 3.1.21.2 0.00000000000000000000000000000000000000000000000000000000000002071 225.0
HKD2_k127_6988002_2 Uncharacterised protein family (UPF0147) K09721 - - 0.000000000000000000000027 101.0
HKD2_k127_6988002_3 PFAM sugar isomerase (SIS) K08094 - 5.3.1.27 0.00000000000000000000003621 103.0
HKD2_k127_6996052_0 Arylsulfotransferase (ASST) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007364 344.0
HKD2_k127_705524_0 Caspase domain - - - 0.0000000000000000002714 93.0
HKD2_k127_705524_1 Psort location Cytoplasmic, score - - - 0.00005811 52.0
HKD2_k127_705524_2 4fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.00009998 48.0
HKD2_k127_7055450_0 TIGRFAM Acetate-CoA ligase K01895 - 6.2.1.1 4.324e-278 868.0
HKD2_k127_7055450_1 Aconitase family (aconitate hydratase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 506.0
HKD2_k127_7055450_2 Fumarate hydratase K01677 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007727 317.0
HKD2_k127_7055450_3 Fe-S type, tartrate fumarate subfamily, beta K01678,K03780 - 4.2.1.2,4.2.1.32 0.00000000000000000000000000000000000000000000000000000000353 206.0
HKD2_k127_7055450_4 COG1522 Transcriptional regulators - - - 0.00000000000000000000005383 111.0
HKD2_k127_7055450_5 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000001466 74.0
HKD2_k127_7068168_0 AAA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000459 263.0
HKD2_k127_7080204_0 Met-10+ like-protein K07055 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 2.5.1.114 0.000000000000000000000000000000000000000000000000000000000000001641 227.0
HKD2_k127_7080204_1 HELICc2 K03722,K10844 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000001484 201.0
HKD2_k127_7119702_0 SMART zinc finger, CDGSH-type domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001694 254.0
HKD2_k127_7119702_1 Belongs to the peptidase S8 family K01342,K14645 - 3.4.21.62 0.00000000000000000003345 103.0
HKD2_k127_7119702_2 cell redox homeostasis K17264 GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0005793,GO:0006457,GO:0006807,GO:0006810,GO:0006887,GO:0006950,GO:0006955,GO:0006986,GO:0008150,GO:0008152,GO:0009100,GO:0009986,GO:0009987,GO:0010033,GO:0012505,GO:0015036,GO:0015037,GO:0016020,GO:0016192,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0019725,GO:0030141,GO:0031410,GO:0031974,GO:0031982,GO:0031983,GO:0031984,GO:0032940,GO:0033554,GO:0034774,GO:0034976,GO:0035580,GO:0035966,GO:0036230,GO:0042119,GO:0042175,GO:0042221,GO:0042581,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0045454,GO:0046903,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055114,GO:0060205,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0097708,GO:0098827,GO:0099503,GO:0140096,GO:1901135,GO:1901564 - 0.0000000003726 66.0
HKD2_k127_7162128_0 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001031 288.0
HKD2_k127_7162128_1 ABC transporter K02003 - - 0.00000000000000000000000427 106.0
HKD2_k127_7162128_2 COG1361 S-layer domain - - - 0.00000000000000000000000486 116.0
HKD2_k127_7169885_0 Alanine-glyoxylate amino-transferase K05825 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003882 350.0
HKD2_k127_7205661_0 Prenyltransferase and squalene oxidase repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000001033 237.0
HKD2_k127_7206505_0 Leucine carboxyl methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001173 257.0
HKD2_k127_7206505_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000000001077 80.0
HKD2_k127_7240857_0 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K02858 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000001674 245.0
HKD2_k127_7240857_1 Aminotransferase class I and II K05825 - - 0.000000000000000000000000003378 113.0
HKD2_k127_7240857_2 Belongs to the eukaryotic ribosomal protein eS17 family K02962 GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.0000000000000001699 81.0
HKD2_k127_7240857_3 Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme K14656 GO:0000166,GO:0001882,GO:0001884,GO:0002135,GO:0003674,GO:0003824,GO:0003919,GO:0005488,GO:0005515,GO:0005524,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009161,GO:0009165,GO:0009259,GO:0009987,GO:0010181,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018130,GO:0019103,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032551,GO:0032553,GO:0032555,GO:0032557,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042726,GO:0042727,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046443,GO:0046444,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072387,GO:0072388,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.7.2 0.000000000000001354 77.0
HKD2_k127_7272074_0 Produces ATP from ADP in the presence of a proton gradient across the membrane K02119 - - 0.0000000000000000000000000000000000000000000000000000000000000000000009995 250.0
HKD2_k127_7272074_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit K02117 - 3.6.3.14,3.6.3.15 0.00000000000000000000000000000000000000000000000000004605 190.0
HKD2_k127_7272074_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02122 - - 0.00000000000000001283 87.0
HKD2_k127_7272074_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000002746 49.0
HKD2_k127_7314815_0 TIGRFAM geranylgeranyl reductase - - - 0.000000000000000000000000000000000000000000000000000196 200.0
HKD2_k127_7314815_1 Flavin containing amine oxidoreductase K10027 - 1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31 0.000000000000000003082 98.0
HKD2_k127_7314815_2 homogentisate phytyltransferase activity K09833 GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006636,GO:0006766,GO:0006775,GO:0006810,GO:0008150,GO:0008152,GO:0008610,GO:0008643,GO:0009058,GO:0009110,GO:0009266,GO:0009507,GO:0009536,GO:0009628,GO:0009915,GO:0009987,GO:0010176,GO:0010189,GO:0010232,GO:0010233,GO:0010354,GO:0015766,GO:0015770,GO:0015772,GO:0016043,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019752,GO:0031347,GO:0032501,GO:0032787,GO:0033559,GO:0042360,GO:0042362,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0046394,GO:0046483,GO:0048583,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0065007,GO:0071554,GO:0071555,GO:0071702,GO:0071704,GO:0071840,GO:0072330,GO:0080134,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617 2.5.1.115,2.5.1.116 0.000000004072 68.0
HKD2_k127_7321138_0 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000004253 221.0
HKD2_k127_7321138_1 - - - - 0.000000000000411 72.0
HKD2_k127_7321138_2 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K02201 - 2.7.7.3 0.000000007035 57.0
HKD2_k127_7324318_0 membrane-associated protein domain - - - 0.00000000001127 78.0
HKD2_k127_7324318_1 Acetyl-coenzyme A transporter 1 - - - 0.0000004394 62.0
HKD2_k127_7335772_0 electron transfer flavoprotein, alpha subunit K03522 - - 0.0000000000000000000000000000000000000000000000000003474 190.0
HKD2_k127_7335772_1 - - - - 0.000000000000000000000000000000000941 136.0
HKD2_k127_7438252_0 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 0.000000000000000000000000000000000000000000000000000000000000001422 224.0
HKD2_k127_7438252_1 Adenosine specific kinase K09129 - - 0.0000000000000000000000000000000000000000000000000000000000009376 214.0
HKD2_k127_7438252_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000003066 63.0
HKD2_k127_7441782_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 2.761e-310 973.0
HKD2_k127_7441782_1 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009541 301.0
HKD2_k127_7441782_2 Enoyl-CoA hydratase/isomerase K13766,K15312 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000002072 250.0
HKD2_k127_7441782_3 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000001355 201.0
HKD2_k127_7460463_0 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000001801 228.0
HKD2_k127_7460463_1 PAC2 family K06869 - - 0.00000000000000000000000000000000000000000000001797 180.0
HKD2_k127_7460463_2 PFAM Uncharacterised protein family UPF0047 - - - 0.00000000000000000000000000000000000000000006754 163.0
HKD2_k127_7460463_3 haloacid dehalogenase-like hydrolase K01091 - 3.1.3.18 0.0000000000000000000004236 103.0
HKD2_k127_7460463_4 PFAM glutaredoxin - - - 0.00000000000000000005206 93.0
HKD2_k127_7460463_5 Lrp/AsnC ligand binding domain - - - 0.0000000000000000002035 90.0
HKD2_k127_7460463_6 Ferredoxin thioredoxin reductase catalytic beta chain - - - 0.00000000006934 64.0
HKD2_k127_7460463_7 - - - - 0.00000606 50.0
HKD2_k127_7492532_0 glutamate synthase K00266,K20202 - 1.4.1.13,1.4.1.14,1.8.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008634 466.0
HKD2_k127_7492532_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000289 238.0
HKD2_k127_7492532_2 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00036 52.0
HKD2_k127_7517185_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001959 334.0
HKD2_k127_7517185_1 snRNP Sm proteins K04796 - - 0.00000000000000001037 85.0
HKD2_k127_7517185_2 Peptidase family C25, C terminal ig-like domain K08589 GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004198,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.22.37 0.000000000008599 78.0
HKD2_k127_7537581_0 Anticodon-binding domain of tRNA K01873 GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 5.935e-231 729.0
HKD2_k127_7540635_0 Copper-exporting ATPase - - - 2.264e-292 911.0
HKD2_k127_7540635_1 homolog of gamma-carboxymuconolactone decarboxylase subunit - - - 0.000000000000000000000000000000000000000019 156.0
HKD2_k127_7540635_2 Short C-terminal domain K08982 - - 0.0000000000000000000000000000001644 126.0
HKD2_k127_7540635_3 Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains K17830 - 1.3.1.101,1.3.7.11 0.00000000000000001933 91.0
HKD2_k127_7540635_4 Protein of unknown function (DUF3795) - - - 0.00000003929 59.0
HKD2_k127_7550277_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002816 459.0
HKD2_k127_7550277_1 Radical SAM - - - 0.000000000000000000000000000000000000003362 156.0
HKD2_k127_7550277_2 response regulator, receiver K07668,K07669 - - 0.0000000000000000000000000000000005805 134.0
HKD2_k127_7550277_3 cheY-homologous receiver domain K07668 - - 0.0000000000000000000000001039 110.0
HKD2_k127_7550277_4 protein histidine kinase activity - - - 0.000000000000000003217 97.0
HKD2_k127_7573368_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0004832,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 1.979e-222 715.0
HKD2_k127_7573368_2 5'-nucleotidase, C-terminal domain K01119 - 3.1.3.6,3.1.4.16 0.0005396 50.0
HKD2_k127_7590146_0 Peptidase family C25 - - - 0.000000000000000000000000000002379 138.0
HKD2_k127_7590146_1 Major Facilitator Superfamily - - - 0.00000000000001093 86.0
HKD2_k127_7612973_0 Heat shock 70 kDa protein K04043 - - 4.024e-240 757.0
HKD2_k127_7612973_1 TCP-1/cpn60 chaperonin family K22447 GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0044183,GO:0051082,GO:0061077 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005013 490.0
HKD2_k127_7612973_2 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000001413 96.0
HKD2_k127_7612973_3 Universal stress protein family - - - 0.000000000000203 76.0
HKD2_k127_7612973_4 PFAM CBS domain containing protein K04767 - - 0.0000000000002336 75.0
HKD2_k127_7657631_0 agmatine deiminase activity K08589,K10536,K20276 GO:0003674,GO:0003824,GO:0004175,GO:0004197,GO:0004198,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.22.37,3.5.3.12 0.000000000000000117 94.0
HKD2_k127_7667736_0 DNA polymerase X family K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005487 299.0
HKD2_k127_7667736_1 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 0.000000000000000000001312 96.0
HKD2_k127_7701053_0 tRNA-splicing ligase RtcB K14415 GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363 6.5.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002263 449.0
HKD2_k127_7701053_1 Phosphopantothenate/pantothenate synthetase K09722 - 6.3.2.36 0.000000000000000000000000000000000000000000000000000000000000000000000000008307 259.0
HKD2_k127_7701053_2 PAC2 family K06869 - - 0.00000000000000000000000000000000000000000000000000000000000002092 223.0
HKD2_k127_7709039_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000000005583 79.0
HKD2_k127_7709039_1 Belongs to the peptidase S8 family K08651 - 3.4.21.66 0.00000002115 66.0
HKD2_k127_7710787_0 ABC transporter K02028 - 3.6.3.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002367 305.0
HKD2_k127_7710787_1 COG0765 ABC-type amino acid transport system, permease component K02029 - - 0.000000000000000000001171 97.0
HKD2_k127_7714450_0 PFAM periplasmic copper-binding - - - 0.000000000000000000008494 109.0
HKD2_k127_7717647_0 Protein of unknown function (DUF763) K09003 - - 0.00000000000000000000000000000000000000000000000000000000000003915 221.0
HKD2_k127_7717647_1 Protein of unknown function (DUF763) K09003 - - 0.0000000000000000000000000000000001314 134.0
HKD2_k127_7717647_2 Acyl-protein synthetase, LuxE - - - 0.00000000000000000000000000004759 132.0
HKD2_k127_7717647_3 Transglutaminase-like superfamily - - - 0.000000001423 69.0
HKD2_k127_7759671_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1055.0
HKD2_k127_7826577_0 Uncharacterised protein family (UPF0227) K07000 - - 0.0000002574 57.0
HKD2_k127_7879892_0 OsmC-like protein K07397 - - 0.0000000000000000000000000000000000000000001191 164.0
HKD2_k127_7879892_1 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000000000006517 156.0
HKD2_k127_7879892_2 COG0517 FOG CBS domain - - - 0.0000000000000000000000000000007905 135.0
HKD2_k127_7879892_3 PFAM Major Facilitator Superfamily - - - 0.00000000000909 77.0
HKD2_k127_7879892_4 membrane-associated protein domain - - - 0.000008735 54.0
HKD2_k127_7879892_5 lycopene cyclase - - - 0.0005 48.0
HKD2_k127_7879892_6 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 0.0006089 44.0
HKD2_k127_7919743_0 SMART Prolyl 4-hydroxylase, alpha subunit - - - 0.0000000000000000000000000000000000000000000000004833 191.0
HKD2_k127_7919743_1 oxidoreductase activity - - - 0.000000000000000000000000008669 122.0
HKD2_k127_7945814_0 transferase activity, transferring glycosyl groups K05889 - 1.1.2.6 0.00000000000000000000000000000003535 145.0
HKD2_k127_7945814_1 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000000000003253 121.0
HKD2_k127_7945814_2 Circadian clock protein KaiC central region K08482 - - 0.00000000000000000000003485 109.0
HKD2_k127_7945814_3 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00004024 51.0
HKD2_k127_7997161_0 Belongs to the peptidase M48B family K03799 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 329.0
HKD2_k127_7997161_1 - - - - 0.000000000000000000000000000000000000000000004417 165.0
HKD2_k127_7997161_2 Pas domain s-box - - - 0.000000000001521 77.0
HKD2_k127_8027468_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 GO:0002161,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 616.0
HKD2_k127_8027468_1 Helix-turn-helix XRE-family like proteins K07731 - - 0.0000000000000000000000000000000000000000000000000000000000000000002974 237.0
HKD2_k127_8027468_2 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.00000000001708 76.0
HKD2_k127_8027468_3 Ribosomal protein S1-like RNA-binding domain K07463 - - 0.000004537 50.0
HKD2_k127_8027468_4 domain, Protein K21449 - - 0.0007594 51.0
HKD2_k127_8078445_0 Belongs to the class-II aminoacyl-tRNA synthetase family K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002255 370.0
HKD2_k127_8078445_1 Signal peptidase K13280 - 3.4.21.89 0.0000000000000000000000000003143 125.0
HKD2_k127_8078445_2 PIN domain of ribonuclease K07060 - - 0.000000000000000000000000007581 116.0
HKD2_k127_8127942_0 PFAM Radical SAM domain protein K22227 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002824 286.0
HKD2_k127_8127942_2 Nitroreductase family - - - 0.0000000000005237 82.0
HKD2_k127_8127942_3 Peptidase family C25 - - - 0.0000000002659 74.0
HKD2_k127_8127942_4 amino acid activation for nonribosomal peptide biosynthetic process K17713,K20952 - - 0.000000003016 70.0
HKD2_k127_8127942_5 EamA-like transporter family K08978 - - 0.0000003456 61.0
HKD2_k127_8127942_6 PFAM Nitroreductase - - - 0.0000005652 63.0
HKD2_k127_8127942_7 Rhomboid family - - - 0.000002671 60.0
HKD2_k127_8127942_8 cellulase activity - - - 0.00001194 58.0
HKD2_k127_8151695_0 Acyl-CoA reductase (LuxC) - - - 0.000000000000000000000000000000000000000000503 171.0
HKD2_k127_8151695_1 SCP-2 sterol transfer family - - - 0.000000000000000000000000000000000156 136.0
HKD2_k127_8154881_0 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007507 503.0
HKD2_k127_8154881_1 TIGRFAM hydrogenase expression formation protein HypD K04654 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003209 405.0
HKD2_k127_8154881_10 redox protein regulator of disulfide bond formation - - - 0.0000000000000000000000000000002162 124.0
HKD2_k127_8154881_11 Belongs to the Fur family K03711,K09825 - - 0.00000000000000000000000000005136 121.0
HKD2_k127_8154881_12 AraC-like ligand binding domain - - - 0.00000000000000000000000001487 119.0
HKD2_k127_8154881_13 Platelet-activating factor acetylhydrolase, isoform II - - - 0.000000000000000003767 96.0
HKD2_k127_8154881_14 PFAM hydrogenase expression formation protein (HUPF HYPC) K04653 - - 0.000000000000002858 78.0
HKD2_k127_8154881_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001038 349.0
HKD2_k127_8154881_3 Rubredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003965 300.0
HKD2_k127_8154881_4 Rubrerythrin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 286.0
HKD2_k127_8154881_5 ZIP Zinc transporter K07238,K16267 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000837 250.0
HKD2_k127_8154881_6 Ferritin-like domain K02217 - 1.16.3.2 0.00000000000000000000000000000000000000000000000000001958 192.0
HKD2_k127_8154881_7 - K07092 - - 0.0000000000000000000000000000000000000000000001647 169.0
HKD2_k127_8154881_8 Rubrerythrin - - - 0.0000000000000000000000000000000000008347 146.0
HKD2_k127_8154881_9 NifU-like N terminal domain K04488 - - 0.00000000000000000000000000000000002451 136.0
HKD2_k127_8176937_0 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 381.0
HKD2_k127_8176937_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.000000000000000000000000000000000000000000000000000000000002076 220.0
HKD2_k127_8176937_2 Protein of unknown function (DUF1624) - - - 0.00000000000000000000000000000000000000000001429 166.0
HKD2_k127_8184982_0 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001485 309.0
HKD2_k127_8184982_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K05580 - 1.6.5.3 0.000000000000000000000832 98.0
HKD2_k127_8184982_2 hydrogenase maturation protease HycI K08315 - 3.4.23.51 0.000000000000000000002553 99.0
HKD2_k127_8184982_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02121 - - 0.000000000000000003969 90.0
HKD2_k127_8184982_4 PFAM H transporting two-sector ATPase C subunit K02124 - - 0.0000000000004592 72.0
HKD2_k127_8197535_0 PFAM Two component regulator propeller - - - 0.00000000183 70.0
HKD2_k127_819969_0 phosphate ABC transporter, inner membrane subunit PstA K02037,K02038 - - 8.108e-229 726.0
HKD2_k127_819969_1 SMART Elongator protein 3 MiaB NifB K04034 - 1.21.98.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008736 534.0
HKD2_k127_819969_2 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001256 391.0
HKD2_k127_819969_3 Plays a role in the regulation of phosphate uptake K02039 - - 0.000000000000000000000000000000000000000000000000000000000000000335 226.0
HKD2_k127_819969_4 COG0226 ABC-type phosphate transport system, periplasmic component K02040 - - 0.00000000000000000000000000000000009652 139.0
HKD2_k127_819969_5 TIGRFAM segregation and condensation protein B K06024 - - 0.000000000000000000000000000000002341 136.0
HKD2_k127_819969_6 deoxyhypusine monooxygenase activity - - - 0.0000001562 57.0
HKD2_k127_819969_7 Glycosyl hydrolases family 18 K01183 - 3.2.1.14 0.0000005016 63.0
HKD2_k127_821065_0 Radical SAM - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003152 269.0
HKD2_k127_821065_1 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611,K09065,K13252 - 2.1.3.3,2.1.3.6,2.1.3.9 0.000000000000000000000000000000000000000000000000001358 189.0
HKD2_k127_821065_2 PQ loop repeat K15383 - - 0.00000000000000000001123 94.0
HKD2_k127_821065_3 Radical SAM - - - 0.0000000007864 70.0
HKD2_k127_821065_4 Methyltransferase domain - - - 0.000000002774 66.0
HKD2_k127_821065_5 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.00000002378 65.0
HKD2_k127_8277477_0 TIGRFAM daunorubicin resistance ABC transporter, inner membrane subunit B K01992 - - 0.00000000000000000000000000000000000000000000000000000001405 204.0
HKD2_k127_8277477_1 ABC transporter K01990 - - 0.00000000000000002706 86.0
HKD2_k127_8292734_0 Mut7-C RNAse domain K09122 - - 0.000000000000000000000000000000003291 134.0
HKD2_k127_8292734_1 Protein of unknown function (DUF424) K09148 - - 0.0000000000000000000000000007661 115.0
HKD2_k127_8292734_2 Papain family cysteine protease - - - 0.00000000000000000000000221 119.0
HKD2_k127_8292734_3 Thermophilic metalloprotease (M29) K19689 - - 0.000000000000002902 75.0
HKD2_k127_8292734_4 Sugar (and other) transporter K08369 - - 0.0000000000837 68.0
HKD2_k127_8292734_5 PFAM Periplasmic copper-binding protein (NosD) K07218 - - 0.0000009118 62.0
HKD2_k127_8294319_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 6.666e-202 646.0
HKD2_k127_8294319_1 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009263 367.0
HKD2_k127_8294319_2 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902494,GO:1903600 4.3.3.6 0.000000000000000000000000000000000000000000000000000000002726 207.0
HKD2_k127_8294319_3 Lrp/AsnC ligand binding domain - - - 0.00000000000000000000000000000002537 126.0
HKD2_k127_8294319_4 - - - - 0.000000000000000000000004478 102.0
HKD2_k127_8294319_5 - - - - 0.0000001573 57.0
HKD2_k127_8314468_0 Alcohol dehydrogenase GroES-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009639 441.0
HKD2_k127_8314468_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 350.0
HKD2_k127_8314468_2 PFAM phosphatidate cytidylyltransferase K18678 - 2.7.1.182 0.0000000000000000000000000000000000000000000000000000000000000835 219.0
HKD2_k127_8314468_3 Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids K17105 - 2.5.1.42 0.0000000000000000000000000000000000000000000000000000000006925 212.0
HKD2_k127_8314468_4 thymidylate kinase K00943 - 2.7.4.9 0.0000000000000000000000000000000000000000000000000000001175 201.0
HKD2_k127_8314468_5 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000005123 180.0
HKD2_k127_8314468_6 - - - - 0.0000000000000000000000001503 112.0
HKD2_k127_8314468_7 Metallophosphoesterase, calcineurin superfamily K07096 - - 0.00000000000000000003778 96.0
HKD2_k127_8314468_8 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04797 - - 0.0000000000001252 76.0
HKD2_k127_8314468_9 oxidoreductase activity K00337,K03333,K04771,K07114 - 1.1.3.6,1.6.5.3,3.4.21.107 0.0000001411 62.0
HKD2_k127_8328187_0 COG3291 FOG PKD repeat - - - 0.000000000000000000000001935 111.0
HKD2_k127_8328187_1 ChaB K06197 - - 0.000000001774 59.0
HKD2_k127_8330448_0 PFAM elongation factor Tu, domain 2 protein - - - 0.00000000000000000000000000000000000000000000000000009512 198.0
HKD2_k127_8330448_1 Flavodoxin - - - 0.00000000000000000000000000000000000000000000001825 176.0
HKD2_k127_8366353_0 Methyltransferase domain K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000001451 108.0
HKD2_k127_8366353_1 Acetyltransferase (GNAT) domain - - - 0.00000000000000000001009 98.0
HKD2_k127_8373521_0 RHS Repeat - - - 0.0001171 52.0
HKD2_k127_8380276_0 Arylsulfotransferase (ASST) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001408 400.0
HKD2_k127_8380276_1 Sulfotransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004149 286.0
HKD2_k127_8380276_2 ABC-2 family transporter protein K01992 - - 0.00000000000001465 78.0
HKD2_k127_8382205_0 Protein of unknown function (DUF996) - - - 0.000000000000000000000000000000000000007994 154.0
HKD2_k127_8382205_1 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.0000000001243 70.0
HKD2_k127_8389807_0 Hydroxymethylglutaryl-CoA reductase, degradative K00054 - 1.1.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009014 511.0
HKD2_k127_8389807_1 PFAM aspartate ornithine carbamoyltransferase carbamoyl-P binding domain K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007534 411.0
HKD2_k127_8389807_2 Involved in allosteric regulation of aspartate carbamoyltransferase K00610 - - 0.0000000000000000000000000000000000000000000000004773 179.0
HKD2_k127_8389807_3 tRNA-splicing ligase RtcB K14415 GO:0000166,GO:0000394,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003972,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0008452,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0017076,GO:0019001,GO:0019002,GO:0030145,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901363 6.5.1.3 0.00000000000000000000000000000000000000000000002891 173.0
HKD2_k127_8389807_4 beta-lactamase domain protein - - - 0.0000000000000000000000000000000000000972 150.0
HKD2_k127_8389807_5 Glyceraldehyde-3-phosphate dehydrogenase K00150 - 1.2.1.59 0.0000000000000000000000008835 106.0
HKD2_k127_8389807_6 Protein of unknown function (DUF504) K09715 - - 0.000000005031 60.0
HKD2_k127_8414723_0 Arylsulfotransferase (ASST) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001361 346.0
HKD2_k127_8414723_1 acetyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000001232 224.0
HKD2_k127_8414723_2 Sulfotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000009541 218.0
HKD2_k127_8418966_0 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007131 314.0
HKD2_k127_8418966_1 bacterial-type flagellum-dependent cell motility - - - 0.000000001182 68.0
HKD2_k127_8437248_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 606.0
HKD2_k127_8437248_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003093 338.0
HKD2_k127_8444341_0 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007096 344.0
HKD2_k127_8444341_1 Pfam matches to PF13186.1 SPASM, and to PF04055.16 Radical_SAM, and to PF13353.1 Fer4_12 - - - 0.000000000000000000000000000000002703 141.0
HKD2_k127_8444341_2 Protein of unknown function (DUF3344) - - - 0.00000000000000000286 98.0
HKD2_k127_8463612_0 NUDIX domain - - - 0.00000000000000000000000000000000001133 139.0
HKD2_k127_8463612_1 dienelactone hydrolase - - - 0.00000000000000000000002021 107.0
HKD2_k127_846774_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 588.0
HKD2_k127_846774_1 Aspartate-ammonia ligase K01914 - 6.3.1.1 0.000000000000000000000000000000000000000005605 157.0
HKD2_k127_846774_2 FKBP-type peptidyl-prolyl cis-trans isomerase K01802 - 5.2.1.8 0.0000000000000000000004614 101.0
HKD2_k127_8534051_0 ubiE/COQ5 methyltransferase family K00574,K07755 - 2.1.1.137,2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006068 336.0
HKD2_k127_8534051_1 Belongs to the pirin family K06911 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 317.0
HKD2_k127_8534051_2 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006862 276.0
HKD2_k127_8534051_3 S-acyltransferase activity K00627,K03310,K03578,K12132 - 2.3.1.12,2.7.11.1,3.6.4.13 0.000000000000000000000000000000000000000000000000000001421 202.0
HKD2_k127_8534051_4 Bacterial periplasmic substrate-binding proteins K02030 - - 0.00000000000000000000000000000000000008814 149.0
HKD2_k127_8534051_5 Predicted SAM-dependent RNA methyltransferase - - - 0.000000000000000000000000000000232 131.0
HKD2_k127_8534051_6 toxin-antitoxin pair type II binding - - - 0.00000000000000000000000000001312 121.0
HKD2_k127_8535933_0 Thiolase, N-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000004355 206.0
HKD2_k127_8535933_1 PFAM PKD domain containing protein - - - 0.0004634 50.0
HKD2_k127_8552944_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 514.0
HKD2_k127_8552944_1 Belongs to the UPF0200 family - - - 0.000000000000000000000000000000000000000001724 162.0
HKD2_k127_8552944_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.000000000000000001068 89.0
HKD2_k127_8560570_0 amine dehydrogenase activity - - - 0.0000000001087 71.0
HKD2_k127_8594152_0 alpha beta - - - 0.00001576 56.0
HKD2_k127_8603321_0 Psort location Cytoplasmic, score K06934 - - 0.00000000000000000000000000000000000000000000006509 172.0
HKD2_k127_8603321_1 COG3039 Transposase and inactivated derivatives, IS5 family - - - 0.0000000116 66.0
HKD2_k127_8609204_0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella - - - 0.00000000000000000000000002418 126.0
HKD2_k127_861280_0 GTPase of unknown function C-terminal K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001725 457.0
HKD2_k127_861280_1 TatD related DNase K07049 - - 0.000000000000005747 79.0
HKD2_k127_8637060_0 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000001042 262.0
HKD2_k127_8637060_1 Peptidase family C25 - - - 0.000000001298 71.0
HKD2_k127_8637060_2 Belongs to the peptidase S8 family K13276,K17734 - - 0.000001973 60.0
HKD2_k127_8653931_0 KaiC K08482 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 591.0
HKD2_k127_8689293_0 ABC-type multidrug transport system, ATPase component K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003002 321.0
HKD2_k127_8689293_1 COG1668 ABC-type Na efflux pump, permease component - - - 0.000000002158 67.0
HKD2_k127_8747458_0 DEAD DEAH box helicase domain protein K03724 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002988 461.0
HKD2_k127_8747458_1 Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes K03622 - - 0.000000000000000000000001594 108.0
HKD2_k127_8747458_2 Transposase IS200 like K07491 - - 0.0001212 48.0
HKD2_k127_8765605_0 calcium- and calmodulin-responsive adenylate cyclase activity K01406 - 3.4.24.40 0.0000000000000000000000004279 116.0
HKD2_k127_8765605_1 transferase activity, transferring glycosyl groups K20276 - - 0.0000123 52.0
HKD2_k127_8770550_0 Arylsulfotransferase (ASST) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 347.0
HKD2_k127_8770550_1 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000195 213.0
HKD2_k127_8770550_2 PFAM Activator of Hsp90 ATPase - - - 0.000000000000000000000000000000000000000002087 161.0
HKD2_k127_8770550_3 Kelch repeat - - - 0.0000000000000003179 91.0
HKD2_k127_8770550_4 Ferritin-like domain - - - 0.00000001169 67.0
HKD2_k127_8805414_0 Belongs to the glycosyl hydrolase 8 (cellulase D) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 302.0
HKD2_k127_8805414_1 DNA polymerase beta domain protein region - - - 0.000000005694 61.0
HKD2_k127_8822221_0 Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) K03124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001469 514.0
HKD2_k127_8822221_1 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000006465 124.0
HKD2_k127_8864530_0 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001681 274.0
HKD2_k127_8864530_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002732 271.0
HKD2_k127_8864530_2 Co Zn Cd efflux system component K16264 - - 0.00000000000000000000000000000000000000000000000000000000000000001556 235.0
HKD2_k127_8864530_3 PFAM ATP-binding region, ATPase domain protein - - - 0.000000000000000000000000000000000000000000001926 186.0
HKD2_k127_8864530_4 Lysine methyltransferase K02493 - 2.1.1.297 0.0000000000000000000000000000000005748 139.0
HKD2_k127_8864530_5 Diguanylate cyclase K21084 - 2.7.7.65 0.0000000000000000002619 103.0
HKD2_k127_8864530_6 Predicted membrane protein (DUF2318) - - - 0.0000000000000000009058 88.0
HKD2_k127_8864530_7 methyltransferase activity K00577 - 2.1.1.86 0.000000000000007626 78.0
HKD2_k127_8864530_8 Bacterial Ig-like domain (group 3) - - - 0.00007521 51.0
HKD2_k127_8874601_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001082 494.0
HKD2_k127_8874601_1 Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA K03265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 466.0
HKD2_k127_8874601_2 Beta-Casp domain K07577 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003972 457.0
HKD2_k127_8874601_3 Clp protease K07403 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005579 338.0
HKD2_k127_8874601_4 PFAM band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007253 292.0
HKD2_k127_8874601_5 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000475 286.0
HKD2_k127_8874601_6 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000159 258.0
HKD2_k127_8874601_7 RNA-binding protein of the translin family K07477 - - 0.000000000000000000000000000000000000003981 155.0
HKD2_k127_8874601_8 General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation K03120 - - 0.00000000000000000000000000001227 125.0
HKD2_k127_8938342_0 - - - - 0.0000000000000000000008007 102.0
HKD2_k127_8938342_1 Cold shock K03704 - - 0.000000000000001496 78.0
HKD2_k127_8938342_2 - - - - 0.000000000008116 70.0
HKD2_k127_8938342_3 - - - - 0.00000000002716 70.0
HKD2_k127_9012282_0 DeoC/LacD family aldolase K08321 - 2.3.1.245 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000011 331.0
HKD2_k127_9031719_0 Peptidase family M48 K03799 - - 0.000000000000000000000000000000000000000000000000000000000000003335 229.0
HKD2_k127_9031719_1 LemA family K03744 - - 0.00000000000000000000000000000000000000000000000000000000002964 210.0
HKD2_k127_9031719_2 PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase K08321 - 2.3.1.245 0.0000000000000000000000003213 106.0
HKD2_k127_9031719_3 Flavodoxin - - - 0.00000000000614 72.0
HKD2_k127_9063085_0 Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails K11600 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 307.0
HKD2_k127_9063085_1 Shwachman-Bodian-Diamond syndrome (SBDS) protein K14574 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000000000000000002256 256.0
HKD2_k127_9063085_2 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome K03679 GO:0000178,GO:0000288,GO:0000291,GO:0000459,GO:0000460,GO:0000466,GO:0000467,GO:0000469,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006364,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0019222,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0031126,GO:0032991,GO:0034470,GO:0034472,GO:0034475,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043144,GO:0043170,GO:0043628,GO:0043928,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071034,GO:0071043,GO:0071051,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.0000000000000000000000000000000000000000000000000000000000000004234 226.0
HKD2_k127_9063085_3 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 - - 0.0000000000000000000000000000000000000000000000000000001878 198.0
HKD2_k127_9064602_0 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate K07558 - 2.7.7.72 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 327.0
HKD2_k127_9064602_1 TatD related DNase K07049 - - 0.000000000000000000000000000000000000000006728 157.0
HKD2_k127_9064602_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.0000000000000000000000000000000000000002868 155.0
HKD2_k127_9064602_3 PAP2 superfamily - - - 0.000000000000000000001076 105.0
HKD2_k127_9099312_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K03307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003968 351.0
HKD2_k127_9099312_1 Saccharopine dehydrogenase K19064 - 1.4.1.18 0.000000000001483 71.0
HKD2_k127_9109584_0 by modhmm K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000004474 238.0
HKD2_k127_9109584_1 NADPH-dependent FMN reductase - - - 0.000000000000000000000000000000008485 134.0
HKD2_k127_9109584_2 - - - - 0.0000009018 61.0
HKD2_k127_9172865_0 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.0000000006208 71.0
HKD2_k127_9175539_0 FG-GAP repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000031 350.0
HKD2_k127_9175539_1 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.0000000000000000000000000000000000000000000000000000009973 211.0
HKD2_k127_9175539_2 - - - - 0.000000000000000000000000000000000000000000000000007877 184.0
HKD2_k127_9175539_3 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.0000000000000000000000000002761 121.0
HKD2_k127_9180434_0 TIGRFAM geranylgeranyl reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001007 268.0
HKD2_k127_9180434_1 - - - - 0.00000008822 63.0
HKD2_k127_9227286_0 Cold shock protein domain K03704 - - 0.0000000000000000005752 87.0
HKD2_k127_9227286_1 acid phosphatase activity K22390 - - 0.0000000000347 73.0
HKD2_k127_9227286_2 Belongs to the DEAD box helicase family - - - 0.000001612 50.0
HKD2_k127_9258136_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1117.0
HKD2_k127_9258136_1 Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 K03243 - - 8.286e-211 670.0
HKD2_k127_9258136_2 Produces ATP from ADP in the presence of a proton gradient across the membrane K02120 - - 0.00000000000000000000000000000004028 127.0
HKD2_k127_9258136_3 SIS domain K13831 - 4.1.2.43,5.3.1.27 0.00000004255 55.0
HKD2_k127_9291028_0 ATP-citrate synthase K01648 GO:0000166,GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003878,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005829,GO:0005886,GO:0006066,GO:0006082,GO:0006084,GO:0006085,GO:0006101,GO:0006107,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006694,GO:0006695,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008144,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009893,GO:0009987,GO:0012505,GO:0015936,GO:0016020,GO:0016053,GO:0016125,GO:0016126,GO:0016192,GO:0016740,GO:0016746,GO:0016999,GO:0017076,GO:0017144,GO:0018130,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030141,GO:0030554,GO:0031323,GO:0031325,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032940,GO:0032991,GO:0033500,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0034774,GO:0035337,GO:0035383,GO:0035384,GO:0035578,GO:0035639,GO:0036094,GO:0036230,GO:0042119,GO:0042582,GO:0042592,GO:0042593,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046165,GO:0046390,GO:0046394,GO:0046483,GO:0046903,GO:0046912,GO:0046949,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0055086,GO:0060205,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0071944,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:0101002,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901568,GO:1901570,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653,GO:1904813 2.3.3.8 9.273e-253 794.0
HKD2_k127_9291028_1 ATP citrate synthase activity K01648 GO:0003674,GO:0003824,GO:0003878,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006084,GO:0006085,GO:0006091,GO:0006101,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046394,GO:0046483,GO:0046912,GO:0051186,GO:0051188,GO:0055086,GO:0071616,GO:0071704,GO:0071944,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.3.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002301 419.0
HKD2_k127_9304506_0 phenylacetate-CoA ligase activity K06046 - 6.2.1.19 0.00000000000001323 86.0
HKD2_k127_9304506_1 Hexapeptide repeat of succinyl-transferase - - - 0.000000000001127 77.0
HKD2_k127_9319594_0 transferase activity, transferring glycosyl groups K01365,K14475 - 3.4.22.15 0.000000000000000000000000000000000000005941 166.0
HKD2_k127_9319594_1 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.0000000000000000000000000000000001913 137.0
HKD2_k127_9319594_2 SMART Elongator protein 3 MiaB NifB - - - 0.0000000000000000005698 88.0
HKD2_k127_9319594_3 Propeptide_C25 - - - 0.000000000000000007945 98.0
HKD2_k127_9340088_0 Fic/DOC family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001724 244.0
HKD2_k127_9340088_1 Domain present in carbohydrate binding proteins and sugar hydrolses - - - 0.000000008654 67.0
HKD2_k127_9410607_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 586.0
HKD2_k127_9410607_1 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000582 64.0
HKD2_k127_9416541_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002716 515.0
HKD2_k127_9416541_1 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002713 354.0
HKD2_k127_9416541_2 PFAM Cold-shock protein, DNA-binding K03704 - - 0.00000000000000007213 83.0
HKD2_k127_94174_0 transmembrane transport K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003843 316.0
HKD2_k127_94174_1 ATPase activity K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002267 306.0
HKD2_k127_94174_2 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids K15888 GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 299.0
HKD2_k127_94174_3 PFAM Major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003603 298.0
HKD2_k127_94174_4 Domain of unknown function (DUF362) - - - 0.0000000000000000000000000000000000000002095 159.0
HKD2_k127_94174_5 Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding K04798 - - 0.00000000002853 66.0
HKD2_k127_9418515_0 - - - - 0.0000000000000000000000001527 114.0
HKD2_k127_9497164_0 PFAM Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000001466 141.0
HKD2_k127_9497164_1 Glycosyl hydrolases family 18 K01183 - 3.2.1.14 0.000154 50.0
HKD2_k127_9508138_0 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain K06978 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001931 469.0
HKD2_k127_9509666_0 FAD linked oxidase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000001382 247.0
HKD2_k127_9509666_1 amino acid activation for nonribosomal peptide biosynthetic process K17713 - - 0.0000000000000000000000000000000000000000000000000004695 204.0
HKD2_k127_9509666_2 esterase K03932 - - 0.0001674 47.0
HKD2_k127_9546084_0 Cadherin-like beta sandwich domain - - - 0.0000003906 61.0
HKD2_k127_9546084_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.000007043 57.0
HKD2_k127_9570213_0 KH, type 1, domain K07041 - - 4.981e-259 812.0
HKD2_k127_9570213_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 310.0
HKD2_k127_9570213_2 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03433 GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0019538,GO:0019774,GO:0030163,GO:0032991,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0070003,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.0000000000000000000000000000000000000000000000000000000000000000000008048 242.0
HKD2_k127_9570213_3 Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair K02683 - - 0.0000000000000000000000000000000003305 139.0
HKD2_k127_9584603_0 Belongs to the eukaryotic ribosomal protein eL15 family K02877 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000001542 223.0
HKD2_k127_9584603_1 peptidase activity, acting on L-amino acid peptides K01337,K05994,K20276 - 3.4.11.10,3.4.21.50 0.00000000000000000000000000000000000002566 163.0
HKD2_k127_9584603_2 PKD domain K19668,K20850 - 3.2.1.157,3.2.1.91 0.000000003125 65.0
HKD2_k127_9584603_3 Universal stress protein family - - - 0.0000001396 56.0
HKD2_k127_9584603_4 PFAM PKD domain containing protein - - - 0.0000005043 63.0
HKD2_k127_9610232_0 deoxyribonuclease I activity K06131,K06915 - - 0.0000000000000000000000000000000000000000000000000000000000000000004498 252.0
HKD2_k127_9610232_1 cell adhesion K11904 - - 0.000000007003 69.0
HKD2_k127_9657226_0 PFAM type II secretion system protein E K07332 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008941 530.0
HKD2_k127_9657226_1 PFAM type II secretion system protein E K07332 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 511.0
HKD2_k127_9672434_0 by modhmm K03655 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001742 315.0
HKD2_k127_9672434_1 Belongs to the peptidase S8 family K14645 - - 0.000000000000000000008707 108.0
HKD2_k127_9682780_0 Sulfotransferase family - - - 0.000000000000000764 81.0
HKD2_k127_9682780_1 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) K01912 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006082,GO:0006725,GO:0006805,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016054,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0017076,GO:0019439,GO:0019748,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0047475,GO:0050896,GO:0051716,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0097159,GO:0097367,GO:0098754,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 6.2.1.30 0.0000000000001597 79.0
HKD2_k127_9712808_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001366 475.0
HKD2_k127_9712808_1 OsmC-like protein K09136 - - 0.000000000000000000000000000000000000000002729 158.0
HKD2_k127_9712808_2 binds to the 23S rRNA K02921 - - 0.0000000000000000000000002981 108.0
HKD2_k127_9712808_3 Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site K12589 GO:0000177,GO:0000178,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0017091,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902494,GO:1905354 - 0.0000000000000000001424 94.0
HKD2_k127_9712808_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03059 - 2.7.7.6 0.000000009192 57.0
HKD2_k127_9712808_5 Transcription factor Pcc1 K09741 - - 0.00003375 50.0
HKD2_k127_973395_0 Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation K03432 GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 0.000000000000000000000000000000000000000000000000000000000000001378 226.0
HKD2_k127_973395_1 Uncharacterized protein conserved in bacteria (DUF2179) - - - 0.00000000000000000000000000000000000000000000000000000000000001163 220.0
HKD2_k127_973395_2 Ribosomal protein S8e K02995 - - 0.000000000000000000000008626 102.0
HKD2_k127_973395_3 SRP19 protein K03105 GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005786,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006617,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0022607,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0034622,GO:0042886,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0065003,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:0097159,GO:1901363,GO:1990904 - 0.00000000207 63.0
HKD2_k127_9751733_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 440.0
HKD2_k127_9751733_1 calcium proton exchanger K07300 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002506 290.0
HKD2_k127_9751733_2 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS K03151 - 2.8.1.4 0.00000000000000000000000000000000000000000001025 171.0
HKD2_k127_9751733_3 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.0000000000000000000000000000000003299 136.0
HKD2_k127_9751733_4 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000009195 132.0
HKD2_k127_9766018_0 Mycolic acid cyclopropane synthetase - - - 0.0000000000000000000000000000003769 129.0
HKD2_k127_9766018_1 guanyl-nucleotide exchange factor activity K01179,K03929,K09612,K12287,K19701,K19702 GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005623,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0036211,GO:0042597,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.2.1.4,3.4.11.10,3.4.11.24,3.4.11.6 0.0000000001825 68.0
HKD2_k127_9766018_2 Zinc metalloprotease (Elastase) K08603,K20273 - 3.4.24.27 0.0000007102 58.0
HKD2_k127_9766018_3 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.000139 54.0
HKD2_k127_9780973_0 Pas domain - - - 0.000000000000000000000000000000000000000000000003783 184.0
HKD2_k127_9780973_1 aminopeptidase activity K05994 - 3.4.11.10 0.0000000000000000000001591 111.0
HKD2_k127_9780973_2 phosphorelay signal transduction system - - - 0.000000000000000000001141 99.0
HKD2_k127_9780973_3 5-oxoproline from various penultimate amino acid residues except L-proline K01304 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:1901564 3.4.19.3 0.000000000000001742 80.0
HKD2_k127_9780973_4 Removes 5-oxoproline from various penultimate amino acid residues except L-proline K01304 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0071704,GO:1901564 3.4.19.3 0.0000000000009162 72.0
HKD2_k127_9780973_5 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase K19200 - - 0.00000122 61.0
HKD2_k127_9824498_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1440.0
HKD2_k127_9917890_0 helicase superfamily c-terminal domain K03724 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002871 516.0
HKD2_k127_992076_0 Helix-turn-helix K07108 - - 0.000000000000007241 79.0
HKD2_k127_992076_1 protein contain chitin-binding domain type 3 K21606 - 3.2.1.202 0.00002653 57.0