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Overview

ID MAG01804
Name HKD2_bin.53
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Chloroflexota
Class Limnocylindria
Order P2-11E
Family P2-11E
Genus CF-39
Species
Assembly information
Completeness (%) 76.76
Contamination (%) 2.74
GC content (%) 69.0
N50 (bp) 11,868
Genome size (bp) 2,287,643

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2161

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10033118_0 Thiamine pyrophosphate enzyme, central domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004937 337.0
HKD2_k127_10033118_1 DNA primase, small subunit K01971 - 6.5.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007979 301.0
HKD2_k127_10033118_2 ATP dependent DNA ligase C terminal region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 295.0
HKD2_k127_10033118_3 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides - - - 0.0000000000000000000000000000000000000000000000005013 184.0
HKD2_k127_10033118_4 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000000007357 107.0
HKD2_k127_10033118_5 Transcriptional regulator, arsR family - - - 0.000000000000001284 81.0
HKD2_k127_10109515_0 Highly conserved protein containing a thioredoxin domain K06888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001329 384.0
HKD2_k127_10109515_1 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000000000009381 155.0
HKD2_k127_10109515_2 Uncharacterized ACR, COG1993 K09137 - - 0.0000000000000000000000000000000000006005 143.0
HKD2_k127_10109515_3 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.00000000000000000000000003067 111.0
HKD2_k127_10109515_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000005735 60.0
HKD2_k127_10109713_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004666 481.0
HKD2_k127_10109713_1 GlcNAc-PI de-N-acetylase - - - 0.0000000000000000000000000000000000000000000000000000000000009026 218.0
HKD2_k127_10109713_2 Helix-hairpin-helix domain K02347 - - 0.0000000000000000000000000000000000000000000000000000003409 199.0
HKD2_k127_10109713_3 GIY-YIG type nucleases (URI domain) K03703 - - 0.0000000000000000000000000000000000000007565 157.0
HKD2_k127_10109713_4 Nudix hydrolase - - - 0.000000000000000000000000000005724 125.0
HKD2_k127_10109713_5 acylphosphatase activity K01512 GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818 3.6.1.7 0.0000000000002529 80.0
HKD2_k127_109925_0 COG0044 Dihydroorotase and related cyclic amidohydrolases K01465 - 3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005181 523.0
HKD2_k127_109925_1 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone K15510 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0019725,GO:0030312,GO:0031406,GO:0036094,GO:0042592,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0046983,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0055114,GO:0065007,GO:0065008,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 1.1.98.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009678 471.0
HKD2_k127_109925_10 Cupin domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000006235 248.0
HKD2_k127_109925_11 ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000002984 244.0
HKD2_k127_109925_12 KR domain K00059,K10617 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000001409 222.0
HKD2_k127_109925_13 Cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000001915 228.0
HKD2_k127_109925_14 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000004437 209.0
HKD2_k127_109925_15 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000001631 196.0
HKD2_k127_109925_16 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000001991 180.0
HKD2_k127_109925_17 Alpha beta hydrolase - - - 0.00000000000000000000000000000001594 142.0
HKD2_k127_109925_18 transcriptional regulator - - - 0.000000000000000000000000000002 132.0
HKD2_k127_109925_19 FCD - - - 0.0000000000000000000000000003822 122.0
HKD2_k127_109925_2 PFAM Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 394.0
HKD2_k127_109925_20 ABC transporter substrate-binding protein K02051 - - 0.00000000001431 76.0
HKD2_k127_109925_21 COG0477 Permeases of the major facilitator superfamily - - - 0.00000000003215 76.0
HKD2_k127_109925_22 PFAM carbon monoxide dehydrogenase subunit G - - - 0.0000000003805 67.0
HKD2_k127_109925_23 electron transfer activity K05337 - - 0.00001871 57.0
HKD2_k127_109925_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003259 369.0
HKD2_k127_109925_4 X-Pro dipeptidyl-peptidase (S15 family) K06889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000468 353.0
HKD2_k127_109925_5 ethanolamine utilization protein K04019 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009642 361.0
HKD2_k127_109925_6 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002032 350.0
HKD2_k127_109925_7 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002179 330.0
HKD2_k127_109925_8 Nitrate ABC transporter ATP-binding protein K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002652 270.0
HKD2_k127_109925_9 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000689 276.0
HKD2_k127_1124787_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 4.786e-234 754.0
HKD2_k127_1124787_1 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004916 424.0
HKD2_k127_1124787_10 PFAM Forkhead-associated protein - - - 0.0000000000000000000000000000000000000000006231 177.0
HKD2_k127_1124787_11 ABC transporter substrate-binding protein K02027 - - 0.000000000000000000000000000000000000000008039 171.0
HKD2_k127_1124787_13 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.0000000000000000000000000000000000003604 141.0
HKD2_k127_1124787_14 - - - - 0.0000000000000000000000000002719 118.0
HKD2_k127_1124787_15 regulatory protein, FmdB family - - - 0.00000000000000000001161 96.0
HKD2_k127_1124787_16 PFAM Forkhead-associated protein - - - 0.000000000000000001847 94.0
HKD2_k127_1124787_17 conserved protein, contains double-stranded beta-helix domain - - - 0.0000000001384 66.0
HKD2_k127_1124787_18 ribonuclease BN K07058 - - 0.0000000001731 71.0
HKD2_k127_1124787_19 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.000000005114 58.0
HKD2_k127_1124787_2 HD domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 392.0
HKD2_k127_1124787_20 SPTR D1C1B9 DinB family protein - - - 0.0000009579 59.0
HKD2_k127_1124787_3 Cell cycle protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 330.0
HKD2_k127_1124787_4 Cell division protein FtsI penicillin-binding protein K05364 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000202 283.0
HKD2_k127_1124787_5 PFAM Binding-protein-dependent transport system inner membrane component K02025 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001731 263.0
HKD2_k127_1124787_6 Major facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000004874 256.0
HKD2_k127_1124787_7 Binding-protein-dependent transport system inner membrane component K02026 - - 0.000000000000000000000000000000000000000000000000000000000000000002436 249.0
HKD2_k127_1124787_8 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.0000000000000000000000000000000000000000000000000000000000000006843 231.0
HKD2_k127_1124787_9 Short-chain dehydrogenase reductase sdr - - - 0.00000000000000000000000000000000000000000000003122 180.0
HKD2_k127_11281_0 - - - - 1.036e-208 695.0
HKD2_k127_11281_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004621 529.0
HKD2_k127_11281_2 BAAT / Acyl-CoA thioester hydrolase C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001016 355.0
HKD2_k127_11281_3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 0.00000000000000000000000000000000000000000000000003298 184.0
HKD2_k127_11281_4 - - - - 0.000009392 54.0
HKD2_k127_1222727_0 Transcriptional regulator, arsR family - - - 0.00000000000000000000007097 102.0
HKD2_k127_1222727_1 Sulfurtransferase TusA - - - 0.0000000000000000308 84.0
HKD2_k127_1222727_2 - K07092 - - 0.0000000000000001253 81.0
HKD2_k127_1222727_3 response regulator - - - 0.000000000189 70.0
HKD2_k127_1222727_4 peptidase C60 sortase A and B - - - 0.0000001649 61.0
HKD2_k127_1239358_0 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000883 321.0
HKD2_k127_1239358_1 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 316.0
HKD2_k127_1239358_2 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 313.0
HKD2_k127_1239358_3 Mur ligase family, catalytic domain K01924 - 6.3.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001199 302.0
HKD2_k127_1239358_4 Cell wall formation K00075 GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0055114,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000001537 244.0
HKD2_k127_1239358_5 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 0.00000000000000000000000000000000000000000000000000000000000000004532 236.0
HKD2_k127_1239358_6 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.0000000000000000000000000000000000000000000000000000000000000005301 234.0
HKD2_k127_1239358_7 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000001958 141.0
HKD2_k127_1286964_0 FAD binding domain K07077 - - 4.376e-241 755.0
HKD2_k127_1286964_1 Peptidase dimerisation domain - - - 1.22e-199 632.0
HKD2_k127_1286964_10 Putative tRNA binding domain K06878 - - 0.000000000000000000000000000000000000001352 156.0
HKD2_k127_1286964_11 - - - - 0.000000000000000000000000000000000001054 156.0
HKD2_k127_1286964_12 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000003487 141.0
HKD2_k127_1286964_13 Protein conserved in bacteria - - - 0.000000000000000000000000000000001527 149.0
HKD2_k127_1286964_14 Serine hydrolase involved in the detoxification of formaldehyde K07214 - - 0.00000000000000000000000000000000678 140.0
HKD2_k127_1286964_15 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000003991 123.0
HKD2_k127_1286964_16 Serine aminopeptidase, S33 K03928 - 3.1.1.1 0.0000000000000000000000000004628 124.0
HKD2_k127_1286964_17 Putative esterase - - - 0.000000000000000000000000003486 129.0
HKD2_k127_1286964_18 ECF sigma factor K03088 - - 0.0000000000000000000000125 108.0
HKD2_k127_1286964_19 Protein of unknown function (DUF971) - - - 0.0000000000000000000004358 107.0
HKD2_k127_1286964_2 Flavin containing amine oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001889 314.0
HKD2_k127_1286964_20 Ferric reductase like transmembrane component K17247 - - 0.000000000000000005976 90.0
HKD2_k127_1286964_22 Tfp pilus assembly protein FimV - - - 0.000001378 59.0
HKD2_k127_1286964_23 mRNA catabolic process K06950,K09163 - - 0.000008414 57.0
HKD2_k127_1286964_3 Vitamin k epoxide reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 301.0
HKD2_k127_1286964_4 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001223 266.0
HKD2_k127_1286964_5 UPF0126 domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005035 256.0
HKD2_k127_1286964_6 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000004765 235.0
HKD2_k127_1286964_7 F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000002996 209.0
HKD2_k127_1286964_8 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000000000000000000000000000000000000000001057 189.0
HKD2_k127_1286964_9 Winged helix DNA-binding domain - - - 0.0000000000000000000000000000000000000000000008565 184.0
HKD2_k127_1320843_0 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002322 411.0
HKD2_k127_1320843_1 PFAM amidohydrolase K01464 - 3.5.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 340.0
HKD2_k127_1320843_2 Protein of unknown function (DUF1385) K09153 - - 0.00000000000000000000000000000000000000000000000001479 188.0
HKD2_k127_1320843_3 DinB superfamily - - - 0.0000005346 59.0
HKD2_k127_1328685_0 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000615 624.0
HKD2_k127_1328685_1 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K12952 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001951 587.0
HKD2_k127_1328685_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009602 565.0
HKD2_k127_1328685_3 ATPase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001893 467.0
HKD2_k127_1328685_4 Alpha galactosidase A C-terminal beta sandwich domain K07407 - 3.2.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 406.0
HKD2_k127_1328685_5 Aminotransferase K00812,K10907 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007301 335.0
HKD2_k127_1328685_6 protein conserved in bacteria - - - 0.0000000000000000000000000000000000002091 155.0
HKD2_k127_1328685_7 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.000000000000000000003314 96.0
HKD2_k127_1328685_8 Diacylglycerol kinase K00901 - 2.7.1.107 0.000000000000005434 84.0
HKD2_k127_1328685_9 VanW like protein - - - 0.000009603 54.0
HKD2_k127_1348968_0 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 1.622e-217 689.0
HKD2_k127_1348968_1 PFAM metal-dependent phosphohydrolase, HD sub domain K01129 - 3.1.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001732 375.0
HKD2_k127_1348968_2 PFAM Dienelactone hydrolase K01061 - 3.1.1.45 0.00000000000000000000000000000000002549 147.0
HKD2_k127_1372167_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 4.951e-248 794.0
HKD2_k127_1372167_1 elongation factor Tu domain 2 protein K06207 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006817 249.0
HKD2_k127_1372167_2 PFAM phosphoesterase, RecJ domain protein K07462 - - 0.0000000000000000000000000000000000000000000000000000000000000000004387 242.0
HKD2_k127_1374860_0 Magnesium chelatase, subunit ChlI K07391 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 466.0
HKD2_k127_1374860_1 tRNA synthetases class I (W and Y) K01867 - 6.1.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 425.0
HKD2_k127_1374860_2 Dienelactone hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005395 419.0
HKD2_k127_1374860_3 Nucleotidyl transferase K00971 - 2.7.7.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000726 308.0
HKD2_k127_1374860_4 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000836 252.0
HKD2_k127_1374860_5 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.000000000000000000000000000000000000000000000000000001484 196.0
HKD2_k127_1374860_6 DNA recombination-mediator protein A K04096 - - 0.000000000000000000000000000000000000001521 161.0
HKD2_k127_1374860_7 Serine aminopeptidase, S33 K07018 - - 0.0000000000000000000002513 106.0
HKD2_k127_1374860_8 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.00003995 50.0
HKD2_k127_137735_0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 7.291e-228 719.0
HKD2_k127_137735_1 Thiamine pyrophosphate enzyme, central domain - - - 1.708e-199 642.0
HKD2_k127_137735_10 CoA-transferase family III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005273 254.0
HKD2_k127_137735_11 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.00000000000000000000000000000000000000000000000000000000000000000000005321 263.0
HKD2_k127_137735_12 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.0000000000000000000000000000000000000000000000000000000000000000001104 241.0
HKD2_k127_137735_13 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000006736 230.0
HKD2_k127_137735_14 Major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000002124 219.0
HKD2_k127_137735_15 Transcriptional regulator K05799 - - 0.00000000000000000000000000000000001346 145.0
HKD2_k127_137735_16 SMART Peptidoglycan-binding LysM - - - 0.0000000000000000000000001549 117.0
HKD2_k127_137735_17 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.000000000000000000000109 106.0
HKD2_k127_137735_18 peptidase K21471 - - 0.00000000000000000009337 103.0
HKD2_k127_137735_19 NMT1-like family - - - 0.0000000000000001775 93.0
HKD2_k127_137735_2 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001707 563.0
HKD2_k127_137735_20 Thiamine pyrophosphate enzyme, central domain - - - 0.00000000000005543 85.0
HKD2_k127_137735_21 NMT1-like family K02051 - - 0.000000000002923 78.0
HKD2_k127_137735_22 Flavin reductase like domain - - - 0.00000000001188 72.0
HKD2_k127_137735_23 Major facilitator superfamily K08153 - - 0.0001918 54.0
HKD2_k127_137735_3 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005381 402.0
HKD2_k127_137735_4 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000658 386.0
HKD2_k127_137735_5 Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) K01823 - 5.3.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000609 343.0
HKD2_k127_137735_6 CoA-transferase family III K07544 - 2.8.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001275 346.0
HKD2_k127_137735_7 COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 308.0
HKD2_k127_137735_8 ATPases associated with a variety of cellular activities K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000301 272.0
HKD2_k127_137735_9 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005676 262.0
HKD2_k127_1377365_0 Voltage gated chloride channel K03281 - - 5.816e-216 689.0
HKD2_k127_1377365_1 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000002099 211.0
HKD2_k127_1377365_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K06996 - - 0.0000000005161 70.0
HKD2_k127_1440026_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 GO:0000049,GO:0000166,GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016020,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046983,GO:0070905,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005583 455.0
HKD2_k127_1440026_1 transferase activity, transferring glycosyl groups K02844 GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005917 294.0
HKD2_k127_1440026_2 -acetyltransferase - - - 0.00000000000000000315 94.0
HKD2_k127_1440026_3 cell adhesion K01278,K03561,K12287,K12686,K20276 GO:0003674,GO:0003824,GO:0016289,GO:0016290,GO:0016787,GO:0016788,GO:0016790,GO:0047617,GO:0052689 3.4.14.5 0.000000000000001664 93.0
HKD2_k127_1440026_4 methyltransferase - - - 0.00000002616 59.0
HKD2_k127_1440026_5 transferase activity, transferring glycosyl groups - - - 0.00005266 58.0
HKD2_k127_1440026_6 domain, Protein - - - 0.000158 56.0
HKD2_k127_1456664_0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III K01835,K01840 - 5.4.2.2,5.4.2.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001179 490.0
HKD2_k127_1456664_1 Bacterial phospho-glucose isomerase C-terminal SIS domain K15916 - 5.3.1.8,5.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000001434 269.0
HKD2_k127_1456664_2 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001684 268.0
HKD2_k127_1456664_3 PFAM NAD-dependent epimerase dehydratase K15856 - 1.1.1.281 0.00000000000000000000000000000000000000000000000000004762 199.0
HKD2_k127_1456664_4 2-phosphosulfolactate phosphatase activity K05979 GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 0.000000000000000000000000000000000000000002097 168.0
HKD2_k127_1456664_5 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000000000000000000000000001711 121.0
HKD2_k127_1456664_6 PFAM zinc finger, SWIM domain protein - - - 0.00000000000000000000002229 103.0
HKD2_k127_1456664_7 NUDIX domain - - - 0.0000000000000000000003049 105.0
HKD2_k127_1456664_8 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07669 - - 0.00000000000000000004038 96.0
HKD2_k127_1467127_0 COGs COG0318 Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 584.0
HKD2_k127_1467127_1 AMP-binding enzyme K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006794 479.0
HKD2_k127_1467127_10 PFAM ABC transporter related - - - 0.0000000000000000000001276 100.0
HKD2_k127_1467127_11 Acetyltransferase (GNAT) family - - - 0.000000000000000007285 95.0
HKD2_k127_1467127_2 AMP-binding enzyme K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004847 451.0
HKD2_k127_1467127_3 Asparaginase K01424,K01444,K13051 GO:0005575,GO:0005623,GO:0042597,GO:0044464 3.4.19.5,3.5.1.1,3.5.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000002289 258.0
HKD2_k127_1467127_4 RibD C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000001349 251.0
HKD2_k127_1467127_5 Transport permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000005279 238.0
HKD2_k127_1467127_6 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000001091 197.0
HKD2_k127_1467127_7 Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma- L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine K20333 - - 0.00000000000000000000000000000001618 134.0
HKD2_k127_1467127_8 GlcNAc-PI de-N-acetylase K22135 - - 0.00000000000000000000000000000003007 134.0
HKD2_k127_1467127_9 COG0491 Zn-dependent hydrolases, including glyoxylases - - - 0.0000000000000000000000000000002026 131.0
HKD2_k127_147595_0 Drug exporters of the RND superfamily K06994 - - 1.672e-195 635.0
HKD2_k127_147595_1 Cytochrome C and Quinol oxidase polypeptide I K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007732 616.0
HKD2_k127_147595_10 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG) K02351 - - 0.000000000000000000000000000000000000000000002247 177.0
HKD2_k127_147595_11 Cytochrome c oxidase subunit III K02276 - 1.9.3.1 0.000000000000000000000000000000000003266 145.0
HKD2_k127_147595_12 Electron transport protein SCO1 SenC K07152 - - 0.00000000000000000000000000000000003192 149.0
HKD2_k127_147595_13 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.00000000000000000000000000000000004475 146.0
HKD2_k127_147595_14 PFAM EamA-like transporter family - - - 0.000000000000000000000000000000004241 131.0
HKD2_k127_147595_15 RDD family - - - 0.00000000000000000000000001284 122.0
HKD2_k127_147595_16 EamA-like transporter family K07790 - - 0.00000000000000000000000004686 119.0
HKD2_k127_147595_17 Domain of unknown function (DUF4350) - - - 0.000000000000000000002509 107.0
HKD2_k127_147595_18 PFAM Penicillinase repressor - - - 0.000000000000000000002928 98.0
HKD2_k127_147595_19 metalloendopeptidase activity - - - 0.0000000000000000001365 100.0
HKD2_k127_147595_2 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007246 429.0
HKD2_k127_147595_20 antibiotic catabolic process K13277 - - 0.000000000000000002152 96.0
HKD2_k127_147595_21 Helix-turn-helix XRE-family like proteins - - - 0.0000000000000001248 93.0
HKD2_k127_147595_22 - - - - 0.0000000000000001294 85.0
HKD2_k127_147595_23 - - - - 0.00000000000001225 81.0
HKD2_k127_147595_25 transferase activity, transferring acyl groups other than amino-acyl groups - - - 0.000000001372 69.0
HKD2_k127_147595_26 Domain of unknown function (DUF4129) - - - 0.0000009469 62.0
HKD2_k127_147595_27 Transcriptional regulator K22298 - - 0.00006738 54.0
HKD2_k127_147595_29 Transcriptional regulatory protein, C terminal - - - 0.0005671 49.0
HKD2_k127_147595_3 ATPase associated with various cellular activities, AAA_3 K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007237 347.0
HKD2_k127_147595_4 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000138 347.0
HKD2_k127_147595_5 PFAM Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004374 320.0
HKD2_k127_147595_6 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005902 279.0
HKD2_k127_147595_7 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000006479 248.0
HKD2_k127_147595_8 Stage II sporulation protein M - - - 0.0000000000000000000000000000000000000000000000000000000001264 216.0
HKD2_k127_147595_9 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000001858 201.0
HKD2_k127_1499878_0 ABC transporter K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001976 598.0
HKD2_k127_1499878_1 ABC transporter, transmembrane K18889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 508.0
HKD2_k127_1499878_2 nucleotide catabolic process K11751 - 3.1.3.5,3.6.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007553 312.0
HKD2_k127_1499878_3 Transmembrane secretion effector - - - 0.0000000000000000000000000000000000757 151.0
HKD2_k127_1499878_4 Bacterial protein of unknown function (DUF881) - - - 0.00000000000000000000000000007992 125.0
HKD2_k127_1499878_5 cyclic nucleotide binding K10914 - - 0.0000000000000000000000000001964 119.0
HKD2_k127_1499878_6 Bacterial protein of unknown function (DUF951) - - - 0.0000000000000000000003419 102.0
HKD2_k127_1499878_7 Bacterial protein of unknown function (DUF881) - - - 0.0000000000001631 79.0
HKD2_k127_1505300_0 Flavin containing amine oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000248 567.0
HKD2_k127_1505300_1 PFAM UBA THIF-type NAD FAD binding protein K21029,K21147 - 2.7.7.80,2.8.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 504.0
HKD2_k127_1505300_10 spore germination - - - 0.00000000000002347 87.0
HKD2_k127_1505300_11 Domain of unknown function (DUF202) K00389 - - 0.0000000001624 67.0
HKD2_k127_1505300_12 PDZ domain (Also known as DHR or GLGF) K03797 - 3.4.21.102 0.00000002291 66.0
HKD2_k127_1505300_13 Domain of unknown function (DUF4149) - - - 0.0001157 51.0
HKD2_k127_1505300_2 Belongs to the peptidase M24B family K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006478 321.0
HKD2_k127_1505300_3 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006453 310.0
HKD2_k127_1505300_4 Adenylate K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000006074 216.0
HKD2_k127_1505300_6 ECF sigma factor K03088 - - 0.00000000000000000000000000000000000001379 152.0
HKD2_k127_1505300_7 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.0000000000000000000000000000000000001009 158.0
HKD2_k127_1505300_8 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 0.0000000000000000000000004475 111.0
HKD2_k127_1505300_9 - - - - 0.00000000000000000002921 104.0
HKD2_k127_1540324_0 ornithine cyclodeaminase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 354.0
HKD2_k127_1540324_1 Protein of unknown function DUF58 - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000007553 247.0
HKD2_k127_1540324_2 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.000000000000000000000000000000000000000000000000000000000007669 223.0
HKD2_k127_1540324_3 PFAM von Willebrand factor type A domain K07114 - - 0.00000000000000000000000000000000000000001177 175.0
HKD2_k127_1540324_5 Uncharacterized conserved protein (DUF2277) - - - 0.00000000000000002745 85.0
HKD2_k127_1540324_6 GAF domain - - - 0.0000000003417 73.0
HKD2_k127_1709174_0 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 520.0
HKD2_k127_1709174_1 Glycosyl hydrolase-like 10 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002533 453.0
HKD2_k127_1709174_10 Domain of unknown function (DUF378) - - - 0.000000000004093 72.0
HKD2_k127_1709174_11 SRPBCC domain-containing protein - - - 0.00000006841 62.0
HKD2_k127_1709174_2 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000778 287.0
HKD2_k127_1709174_3 B12 binding domain K22491 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006824 257.0
HKD2_k127_1709174_4 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002228 242.0
HKD2_k127_1709174_5 metal-dependent hydrolase with the TIM-barrel fold - - - 0.0000000000000000000000000000000000000000000000000002693 195.0
HKD2_k127_1709174_6 PFAM OsmC family protein K04063 - - 0.0000000000000000000000000000000000000000002306 164.0
HKD2_k127_1709174_7 Nodulation protein S (NodS) - - - 0.00000000000000000000000000000000000000001341 159.0
HKD2_k127_1709174_8 tRNA wobble cytosine modification - - - 0.0000000000000000000000000000000000000001469 166.0
HKD2_k127_1709174_9 COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) K05770 - - 0.000000000000000000000000000000000000000211 154.0
HKD2_k127_174129_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006017 454.0
HKD2_k127_174129_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009574 323.0
HKD2_k127_174129_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006008 326.0
HKD2_k127_174129_3 Riboflavin synthase K00793 GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 0.00000000000000000000000000000000000000000000000000000001462 203.0
HKD2_k127_174129_4 Acetyltransferase (GNAT) family - - - 0.00000000000000001277 94.0
HKD2_k127_1769803_0 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004405 493.0
HKD2_k127_1769803_1 Belongs to the GARS family K01945 - 6.3.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004569 346.0
HKD2_k127_1769803_2 Adenylosuccinate lyase K01756 - 4.3.2.2 0.000000000000000000000000000000000000000000000000000006303 198.0
HKD2_k127_1769803_3 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.000000000000000000000000000000000000001936 158.0
HKD2_k127_1791535_0 Alcohol dehydrogenase GroES-like domain K00008,K00060,K08322 - 1.1.1.103,1.1.1.14,1.1.1.380 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003857 375.0
HKD2_k127_1791535_1 LVIVD repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 372.0
HKD2_k127_1791535_10 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000007554 85.0
HKD2_k127_1791535_11 Nitroreductase family - - - 0.0000000000003682 82.0
HKD2_k127_1791535_12 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000005106 77.0
HKD2_k127_1791535_2 periplasmic binding protein LacI transcriptional regulator K02529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000261 256.0
HKD2_k127_1791535_3 ABC transporter K02049 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002122 257.0
HKD2_k127_1791535_4 ABC-type nitrate sulfonate bicarbonate transport system, permease component K02050 - - 0.000000000000000000000000000000000000000000000000000000000006722 229.0
HKD2_k127_1791535_5 PFAM cyclase family protein - - - 0.0000000000000000000000000000000000000000000000000000001711 203.0
HKD2_k127_1791535_6 alcohol dehydrogenase K00008,K08322 - 1.1.1.14,1.1.1.380 0.000000000000000000000000000000000000001143 154.0
HKD2_k127_1791535_7 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000008835 106.0
HKD2_k127_1791535_8 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K01652 - 2.2.1.6 0.00000000000000000000218 97.0
HKD2_k127_1791535_9 PFAM NMT1 THI5 like domain protein K02051 - - 0.0000000000000000008419 101.0
HKD2_k127_1841125_0 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 438.0
HKD2_k127_1841125_1 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 426.0
HKD2_k127_1841125_10 Zincin-like metallopeptidase - - - 0.00000000000000000000000000002156 128.0
HKD2_k127_1841125_11 4Fe-4S dicluster domain - - - 0.0000000000000001451 88.0
HKD2_k127_1841125_12 Protein of unknown function DUF58 - - - 0.0000000000000007782 83.0
HKD2_k127_1841125_13 Acetyltransferase (GNAT) domain - - - 0.000000000000001323 84.0
HKD2_k127_1841125_14 - - - - 0.000000000000001437 80.0
HKD2_k127_1841125_15 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.0000000000002384 78.0
HKD2_k127_1841125_16 Protein of unknown function (DUF1761) - - - 0.0000001041 60.0
HKD2_k127_1841125_17 PFAM metal-dependent phosphohydrolase, HD sub domain K01524,K07012 - 3.6.1.11,3.6.1.40 0.000499 50.0
HKD2_k127_1841125_2 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001347 338.0
HKD2_k127_1841125_3 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 308.0
HKD2_k127_1841125_4 Allantoate amidohydrolase K02083 - 3.5.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004556 286.0
HKD2_k127_1841125_5 PFAM transglutaminase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005001 295.0
HKD2_k127_1841125_6 Ribulose-phosphate 3 epimerase family K01783 GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 0.000000000000000000000000000000000000000000000000000000000000000005367 235.0
HKD2_k127_1841125_7 - - - - 0.000000000000000000000000000000000000000000000002589 182.0
HKD2_k127_1841125_8 Transcription regulator MerR DNA binding K21902 - - 0.000000000000000000000000000000000000000001055 160.0
HKD2_k127_1841125_9 Aminoacyl-tRNA editing domain - - - 0.0000000000000000000000000000000002019 140.0
HKD2_k127_1872828_0 Sensor_kinase_SpoOB-type, alpha-helical domain K02476 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007395 438.0
HKD2_k127_1872828_1 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003317 397.0
HKD2_k127_1872828_10 Receptor family ligand binding region K01999 - - 0.000000000000000000000000000000007789 145.0
HKD2_k127_1872828_11 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.00000000000002154 87.0
HKD2_k127_1872828_12 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.0000000003076 73.0
HKD2_k127_1872828_13 PFAM Transcription regulator LuxR, C-terminal - - - 0.000006537 52.0
HKD2_k127_1872828_14 PFAM Extracellular ligand-binding receptor K01999 - - 0.00003596 56.0
HKD2_k127_1872828_2 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001274 397.0
HKD2_k127_1872828_3 Binding-protein-dependent transport system inner membrane component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003914 349.0
HKD2_k127_1872828_4 3-hydroxyacyl-CoA dehydrogenase domain protein K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006945 347.0
HKD2_k127_1872828_5 ABC transporter, phosphonate, periplasmic substrate-binding protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001941 341.0
HKD2_k127_1872828_6 Dehydrogenase E1 component K00166 - 1.2.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003773 295.0
HKD2_k127_1872828_7 cheY-homologous receiver domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001265 268.0
HKD2_k127_1872828_8 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000004662 262.0
HKD2_k127_1872828_9 beta-lactamase domain protein K13075 - 3.1.1.81 0.00000000000000000000000000000000004284 150.0
HKD2_k127_1877978_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 1.072e-218 706.0
HKD2_k127_1877978_1 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002535 377.0
HKD2_k127_1877978_2 Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) K01433 - 3.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002127 338.0
HKD2_k127_1877978_3 Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003276 301.0
HKD2_k127_1877978_4 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 294.0
HKD2_k127_1877978_5 COG0437 Fe-S-cluster-containing hydrogenase components 1 K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004444 254.0
HKD2_k127_1877978_6 zinc metalloprotease K04771,K11749,K16922 GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0040007,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000002025 234.0
HKD2_k127_1877978_7 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000001826 119.0
HKD2_k127_1877978_8 Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide K00806 - 2.5.1.31 0.0000000000000000001971 88.0
HKD2_k127_1877978_9 Protein of unknown function (DUF664) - - - 0.00000156 60.0
HKD2_k127_2023687_0 GTPase that plays an essential role in the late steps of ribosome biogenesis K00058,K03977 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004893 466.0
HKD2_k127_2023687_1 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006073 426.0
HKD2_k127_2023687_10 Redoxin - - - 0.00000000000000000000000000158 114.0
HKD2_k127_2023687_11 Carboxypeptidase regulatory-like domain - - - 0.00000000000000000000002567 115.0
HKD2_k127_2023687_12 Cysteine-rich secretory protein family - - - 0.0000000000000000000001007 113.0
HKD2_k127_2023687_13 Catalyzes the dephosphorylation of D,L-glyceraldehyde 3- phosphate in vitro K07025 - - 0.00000000000000004901 92.0
HKD2_k127_2023687_14 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0070887 - 0.000000000001309 72.0
HKD2_k127_2023687_15 signal peptide processing - - - 0.000000001133 64.0
HKD2_k127_2023687_16 Redoxin - - - 0.00000000172 60.0
HKD2_k127_2023687_17 Sensory domain found in PocR K07315 - 3.1.3.3 0.00006946 49.0
HKD2_k127_2023687_2 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003709 288.0
HKD2_k127_2023687_3 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000000000000000000000000000000001006 237.0
HKD2_k127_2023687_4 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K02945,K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000001637 236.0
HKD2_k127_2023687_5 deaminated base DNA N-glycosylase activity K03648,K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000002637 191.0
HKD2_k127_2023687_6 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.000000000000000000000000000000000003569 144.0
HKD2_k127_2023687_7 Alternative locus ID K00518 - 1.15.1.1 0.0000000000000000000000000000000001355 136.0
HKD2_k127_2023687_8 Phosphate acyltransferases K00655 - 2.3.1.51 0.000000000000000000000000000000009275 136.0
HKD2_k127_2023687_9 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000005858 131.0
HKD2_k127_2072807_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 388.0
HKD2_k127_2072807_1 PolyA polymerase K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003121 348.0
HKD2_k127_2072807_2 PFAM ABC transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000852 290.0
HKD2_k127_2072807_3 COG0411 ABC-type branched-chain amino acid transport systems, ATPase component K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008934 297.0
HKD2_k127_2072807_4 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002468 285.0
HKD2_k127_2072807_5 Belongs to the binding-protein-dependent transport system permease family K01997,K11956 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004694 279.0
HKD2_k127_2072807_6 DinB family - - - 0.000000000001939 76.0
HKD2_k127_2116173_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002178 351.0
HKD2_k127_2116173_1 Rhodanese Homology Domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000742 243.0
HKD2_k127_2116173_2 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 0.0000000000000000000000000000000000000000000000000000000000000000007141 242.0
HKD2_k127_2116173_3 hydroperoxide reductase activity - - - 0.0000000000000000000000000000001788 133.0
HKD2_k127_2116173_4 recombinase XerD K04763 GO:0008150,GO:0040007 - 0.00000000000000000000000009639 119.0
HKD2_k127_2116173_5 Polymer-forming cytoskeletal - - - 0.00000000000000000006786 95.0
HKD2_k127_2116173_6 - - - - 0.000000000001982 75.0
HKD2_k127_2116173_7 - - - - 0.000000001822 72.0
HKD2_k127_2116173_8 COG0526 Thiol-disulfide isomerase and thioredoxins K00384 - 1.8.1.9 0.0000003136 57.0
HKD2_k127_2116173_9 intermembrane phospholipid transfer K07323 - - 0.000003355 60.0
HKD2_k127_212469_0 Aminotransferase class I and II - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 467.0
HKD2_k127_212469_1 Luciferase-like monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000419 316.0
HKD2_k127_212469_2 Arsenical pump membrane protein K03893 - - 0.000000000000000000000000000000000000000000000000000000000000001292 234.0
HKD2_k127_212469_3 - - - - 0.0000000000000000000000009131 113.0
HKD2_k127_212469_4 Cupin domain - - - 0.0000000000000000007138 89.0
HKD2_k127_212469_5 PFAM regulatory protein TetR - - - 0.0000000000000007687 85.0
HKD2_k127_2137437_0 Histidyl-tRNA synthetase K01892 - 6.1.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000003033 255.0
HKD2_k127_2137437_1 Fumarase C C-terminus K01744 - 4.3.1.1 0.0000000000000000000000000000000000000009081 152.0
HKD2_k127_2137437_2 - - - - 0.00000000000000000000000000000001549 146.0
HKD2_k127_2137437_3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768,K09565 - 5.2.1.8 0.0000000000000000000000000000008183 128.0
HKD2_k127_2137437_4 Cupin - - - 0.000000000000000000000000000191 125.0
HKD2_k127_2181038_0 Crp Fnr family K21564 - - 0.0000000000000000000000000000000000000000000000000000000005583 211.0
HKD2_k127_2181038_1 GDP-mannose mannosyl hydrolase activity K03574 - 3.6.1.55 0.0000000000000000000000000000000000000000002658 163.0
HKD2_k127_2181038_2 Uncharacterized conserved protein (DUF2249) - - - 0.00000000000000000000000000000000003497 150.0
HKD2_k127_2181038_3 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000004857 128.0
HKD2_k127_2181038_4 Metal-sensitive transcriptional repressor K21600 - - 0.00000000000000000000001696 105.0
HKD2_k127_2181038_5 Domain of unknown function (DUF1858) - - - 0.0000000001254 65.0
HKD2_k127_2181038_6 Cation transport ATPase K17686 - 3.6.3.54 0.0000006982 56.0
HKD2_k127_2231926_0 PFAM extracellular solute-binding protein family 5 K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001067 516.0
HKD2_k127_2231926_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 352.0
HKD2_k127_2288856_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001911 413.0
HKD2_k127_2288856_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 332.0
HKD2_k127_2288856_2 Transcriptional regulatory protein, C terminal K07667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000964 285.0
HKD2_k127_2288856_3 Hsp70 protein K04046 - - 0.000000000000000000000000000000000000008239 155.0
HKD2_k127_2288856_4 SPTR D1CGX5 Response regulator receiver protein - - - 0.0000000000000000000000000000000000211 140.0
HKD2_k127_2395521_0 Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) K02549 - 4.2.1.113 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 391.0
HKD2_k127_2395521_1 water channel activity K02440,K06188,K09874 - - 0.00000000000000000000000000000000000000000000000000000003804 203.0
HKD2_k127_2395521_2 carboxylic acid catabolic process - - - 0.00000000000000000000000000000000000000000001014 173.0
HKD2_k127_2395521_3 Formiminotransferase-cyclodeaminase K00603,K01746,K13990 - 2.1.2.5,4.3.1.4 0.000000000000000000000000000000000000000009653 156.0
HKD2_k127_2395521_4 Chromate resistance exported protein - - - 0.00000000000000000000000000000000000279 156.0
HKD2_k127_2395521_5 cyclic nucleotide binding K09766,K10914 - - 0.0000000000000000000000000544 117.0
HKD2_k127_2399702_0 PFAM Adenylyl cyclase class-3 4 guanylyl cyclase - - - 1.302e-196 651.0
HKD2_k127_2399702_1 PFAM Isochorismatase K08281 - 3.5.1.19 0.0000000000000000000000000000000000002459 153.0
HKD2_k127_2399702_2 Domain of unknown function (DU1801) - - - 0.0000000000000000001053 93.0
HKD2_k127_2399702_3 cell adhesion involved in biofilm formation - - - 0.0004635 51.0
HKD2_k127_243369_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 2.496e-251 784.0
HKD2_k127_243369_1 PFAM UvrD REP helicase K03657 - 3.6.4.12 8.477e-205 661.0
HKD2_k127_243369_10 Ferric reductase like transmembrane component - - - 0.0000000000000000000000003756 119.0
HKD2_k127_243369_11 Anti-sigma-K factor rskA - - - 0.000000001145 69.0
HKD2_k127_243369_12 Domain of unknown function (DU1801) - - - 0.00000006015 63.0
HKD2_k127_243369_2 Alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002536 324.0
HKD2_k127_243369_3 Mandelate racemase muconate lactonizing enzyme K01683 - 4.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000001932 263.0
HKD2_k127_243369_4 ECF sigma factor K03088 - - 0.0000000000000000000000000000000000000000000000012 182.0
HKD2_k127_243369_5 Carboxymuconolactone decarboxylase family K01607 - 4.1.1.44 0.0000000000000000000000000000000000000000003982 163.0
HKD2_k127_243369_6 GGDEF domain' - - - 0.000000000000000000000000000000000000000008761 176.0
HKD2_k127_243369_7 PFAM VanW family protein - - - 0.00000000000000000000000000000000000003295 156.0
HKD2_k127_243369_8 PFAM YbaK prolyl-tRNA synthetase associated region K19055 - - 0.00000000000000000000000000000000001423 151.0
HKD2_k127_243369_9 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.00000000000000000000000000000004016 129.0
HKD2_k127_246278_0 Transcriptional regulatory protein, C terminal K02483,K07669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007434 265.0
HKD2_k127_246278_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00184 - - 0.000000000000000000000000000000003687 135.0
HKD2_k127_246278_2 - K07234 - - 0.00000000000000000002472 105.0
HKD2_k127_248514_0 Domain of unknown function (DUF1998) K06877 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004441 520.0
HKD2_k127_248514_1 helicase superfamily c-terminal domain K06877 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002725 393.0
HKD2_k127_248514_2 SMART alpha amylase catalytic sub domain K01187 - 3.2.1.20 0.00000005178 57.0
HKD2_k127_2534061_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002378 412.0
HKD2_k127_2534061_1 Beta-galactosidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 355.0
HKD2_k127_2534061_10 PFAM ABC transporter related K02193 - 3.6.3.41 0.00000000000000000000000000000000000000002658 166.0
HKD2_k127_2534061_11 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000004172 136.0
HKD2_k127_2534061_12 - - - - 0.0000000000000000000003286 109.0
HKD2_k127_2534061_13 hyperosmotic response K04065 - - 0.000000000000000005134 92.0
HKD2_k127_2534061_14 Low affinity iron permease - - - 0.0000000008965 64.0
HKD2_k127_2534061_15 ABC-2 family transporter protein - - - 0.0000002152 61.0
HKD2_k127_2534061_2 Belongs to the GHMP kinase family. GalK subfamily K00849 - 2.7.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001303 323.0
HKD2_k127_2534061_3 Psort location CytoplasmicMembrane, score - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001018 331.0
HKD2_k127_2534061_4 Pyridoxal-phosphate dependent enzyme K01751 - 4.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000001844 237.0
HKD2_k127_2534061_5 - - - - 0.000000000000000000000000000000000000000000000000001262 198.0
HKD2_k127_2534061_6 MFS_1 like family - - - 0.0000000000000000000000000000000000000000000000003 192.0
HKD2_k127_2534061_7 AAA ATPase domain - - - 0.0000000000000000000000000000000000000000000000009318 199.0
HKD2_k127_2534061_8 lactoylglutathione lyase activity K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000001069 177.0
HKD2_k127_2534061_9 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000000000000000000001104 165.0
HKD2_k127_2564368_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 0.0 1314.0
HKD2_k127_2564368_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006968 363.0
HKD2_k127_2564368_10 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000002158 101.0
HKD2_k127_2564368_11 Cyclic nucleotide-monophosphate binding domain - - - 0.0002629 52.0
HKD2_k127_2564368_12 Ribosomally synthesized peptide prototyped by Frankia Franean1_4349. - - - 0.00062 50.0
HKD2_k127_2564368_2 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 308.0
HKD2_k127_2564368_3 Peptidase family M20/M25/M40 K02083,K06016 - 3.5.1.6,3.5.1.87,3.5.3.9 0.000000000000000000000000000000000000000000000000000000000000000000004105 249.0
HKD2_k127_2564368_4 ATPase activity K16922 - - 0.000000000000000000000000000000000000000000000000000009972 216.0
HKD2_k127_2564368_5 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B K02823 - - 0.000000000000000000000000000000000000000000000005676 186.0
HKD2_k127_2564368_6 transcriptional regulator K10914 GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - 0.000000000000000000000000000000000000002884 155.0
HKD2_k127_2564368_7 lactoylglutathione lyase activity - - - 0.0000000000000000000000000000000000004387 148.0
HKD2_k127_2564368_8 Major facilitator Superfamily - - - 0.000000000000000000000003197 115.0
HKD2_k127_2564368_9 - - - - 0.000000000000000000006597 93.0
HKD2_k127_2572645_0 TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC K01531 - 3.6.3.2 5.15e-254 807.0
HKD2_k127_2572645_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 7.888e-248 788.0
HKD2_k127_2572645_10 COG3911 Predicted ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000759 261.0
HKD2_k127_2572645_11 Phage shock protein A K03969 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003175 257.0
HKD2_k127_2572645_12 dienelactone hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001546 243.0
HKD2_k127_2572645_13 PFAM glycosyl transferase, family 51 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001718 249.0
HKD2_k127_2572645_14 Domain present in PSD-95, Dlg, and ZO-1/2. K04771,K08070 - 1.3.1.74,3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000002581 246.0
HKD2_k127_2572645_15 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000002114 243.0
HKD2_k127_2572645_16 Belongs to the peptidase M50B family - - - 0.00000000000000000000000000000000000000000000000000000000000000006372 236.0
HKD2_k127_2572645_17 Belongs to the carbohydrate kinase PfkB family. LacC subfamily K00882 - 2.7.1.56 0.00000000000000000000000000000000000000000000000000000000000237 225.0
HKD2_k127_2572645_18 Arginyl tRNA synthetase N terminal dom K01887 GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 0.000000000000000000000000000000000000000000000000000000000002564 218.0
HKD2_k127_2572645_19 Phosphoribosyl transferase domain - - - 0.000000000000000000000000000000000000000000000000000000000003273 215.0
HKD2_k127_2572645_2 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004319 579.0
HKD2_k127_2572645_20 - - - - 0.00000000000000000000000000000000000000000000000000000002386 204.0
HKD2_k127_2572645_21 TPM domain - - - 0.000000000000000000000000000000000000000000000000000001778 214.0
HKD2_k127_2572645_22 - - - - 0.0000000000000000000000000000000000000000046 163.0
HKD2_k127_2572645_23 Radical SAM superfamily - - - 0.0000000000000000000000000000000000002336 153.0
HKD2_k127_2572645_24 Protein of unknown function (DUF3048) C-terminal domain - - - 0.0000000000000000000000000000000000004784 161.0
HKD2_k127_2572645_25 Negative regulator of - - - 0.0000000000000000000000000000000000006258 154.0
HKD2_k127_2572645_26 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.0000000000000000000000000000000004173 141.0
HKD2_k127_2572645_27 SMART Transport-associated and nodulation region - - - 0.000000000000000000000000000000001148 139.0
HKD2_k127_2572645_28 Major facilitator Superfamily - - - 0.0000000000000000000000000000009969 137.0
HKD2_k127_2572645_29 Histidine kinase - - - 0.0000000000000000000000001476 122.0
HKD2_k127_2572645_3 Alcohol dehydrogenase GroES-like domain K13953 - 1.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 432.0
HKD2_k127_2572645_30 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.00000000000000000000129 107.0
HKD2_k127_2572645_31 Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently - GO:0000394,GO:0003674,GO:0005488,GO:0005509,GO:0006139,GO:0006388,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008380,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:1901360 - 0.000000000000000000002439 107.0
HKD2_k127_2572645_33 AMP binding - - - 0.0000000000000000001785 98.0
HKD2_k127_2572645_34 Peptidase family M23 K21471 - - 0.0000000000000007691 91.0
HKD2_k127_2572645_35 PFAM major facilitator superfamily MFS_1 - - - 0.0000000000002166 82.0
HKD2_k127_2572645_36 FAD linked oxidases, C-terminal domain K00104 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 1.1.3.15 0.000000000007999 76.0
HKD2_k127_2572645_37 hyperosmotic response - - - 0.000000001592 66.0
HKD2_k127_2572645_38 Bulb-type mannose-specific lectin - - - 0.0000000592 66.0
HKD2_k127_2572645_4 Belongs to the glycosyl hydrolase 57 family K22451 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008957 443.0
HKD2_k127_2572645_5 Belongs to the glycosyl hydrolase 57 family K16149 - 2.4.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002658 406.0
HKD2_k127_2572645_6 ABC transporter substrate-binding protein K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001646 390.0
HKD2_k127_2572645_7 Sugar (and other) transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 378.0
HKD2_k127_2572645_8 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 329.0
HKD2_k127_2572645_9 lactoylglutathione lyase activity K01724 - 4.2.1.96 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002108 305.0
HKD2_k127_2623345_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 559.0
HKD2_k127_2623345_1 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00647,K09458 - 2.3.1.179,2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000002507 263.0
HKD2_k127_2623345_2 Peptidase family S51 - - - 0.00000000000000000000000001042 119.0
HKD2_k127_2629958_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 366.0
HKD2_k127_2629958_1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004187 299.0
HKD2_k127_2629958_2 Calcineurin-like phosphoesterase K01077 - 3.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005364 300.0
HKD2_k127_2629958_3 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.000000000000000000000000000000001208 145.0
HKD2_k127_2629958_4 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000008583 78.0
HKD2_k127_2640983_0 Belongs to the amidase family K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002754 455.0
HKD2_k127_2640983_1 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000045 396.0
HKD2_k127_2640983_2 Belongs to the peptidase M24B family K01271,K01274 - 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001925 359.0
HKD2_k127_2640983_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003411 346.0
HKD2_k127_2640983_4 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.0000000000000000000000000000000000000000000000000000000000001338 217.0
HKD2_k127_2640983_5 Small hydrophilic plant seed protein - - - 0.0000000000000000000000000002308 119.0
HKD2_k127_2640983_6 Lytic transglycolase - - - 0.00000000000000001148 93.0
HKD2_k127_2640983_7 Iron-sulphur cluster biosynthesis K15724 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:1901564 - 0.0000000000000000407 87.0
HKD2_k127_2640983_8 peptidase C60 sortase A and B - - - 0.00002057 55.0
HKD2_k127_2643430_0 Pyridoxal-dependent decarboxylase conserved domain K01593 - 4.1.1.105,4.1.1.28 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 536.0
HKD2_k127_2643430_1 Polysaccharide biosynthesis protein K01711,K15856 - 1.1.1.281,4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002439 411.0
HKD2_k127_2643430_2 Double zinc ribbon - - - 0.000000000000000000000000000000002936 134.0
HKD2_k127_2643430_3 alpha-ribazole phosphatase activity K02226,K07814 - 3.1.3.73 0.0000000003456 68.0
HKD2_k127_2643430_4 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.000007049 49.0
HKD2_k127_2665782_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008179 575.0
HKD2_k127_2665782_1 PFAM molybdopterin binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003162 314.0
HKD2_k127_2665782_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003695 295.0
HKD2_k127_2665782_3 VanW like protein - - - 0.00000000000000000000000000000000000002766 164.0
HKD2_k127_2665782_4 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000001785 125.0
HKD2_k127_2665782_5 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000001192 127.0
HKD2_k127_2665782_6 - - - - 0.0000000000000001817 79.0
HKD2_k127_2665782_7 Tfp pilus assembly protein FimV - - - 0.00003397 55.0
HKD2_k127_2665782_8 Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family K10396 GO:0003674,GO:0003774,GO:0003777,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005871,GO:0005875,GO:0006928,GO:0007017,GO:0007018,GO:0008150,GO:0009987,GO:0015630,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044422,GO:0044424,GO:0044430,GO:0044446,GO:0044464 - 0.0008175 45.0
HKD2_k127_2685170_0 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009218 366.0
HKD2_k127_2685170_1 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K09699 - 2.3.1.168 0.00000000000000000000000000000000000000000000000000000000000002177 223.0
HKD2_k127_2685170_2 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.00000000000000000000000000000000000000000000002064 181.0
HKD2_k127_2685170_3 4Fe-4S binding domain - - - 0.0000000000000000000000000000000000002285 141.0
HKD2_k127_2685170_4 GYD domain - - - 0.00000000000000000000000000003384 120.0
HKD2_k127_2685170_5 Uncharacterized conserved protein (DUF2203) - - - 0.00000000000000000001232 95.0
HKD2_k127_2685170_6 hyperosmotic response K04065 - - 0.0000000000000000005803 98.0
HKD2_k127_2693513_0 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 411.0
HKD2_k127_2693513_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002024 319.0
HKD2_k127_2693513_10 periplasmic binding protein K02016 - - 0.00000000000000000000000000000000000000003544 158.0
HKD2_k127_2693513_11 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor K03524 - 6.3.4.15 0.00000000000000000000000000000013 133.0
HKD2_k127_2693513_12 Permease - - - 0.000000000000000000000000000000854 135.0
HKD2_k127_2693513_13 Branched-chain amino acid transport protein (AzlD) - - - 0.0000000000001814 82.0
HKD2_k127_2693513_14 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.0003948 51.0
HKD2_k127_2693513_2 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 293.0
HKD2_k127_2693513_3 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000002768 261.0
HKD2_k127_2693513_4 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001442 255.0
HKD2_k127_2693513_5 Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate K00872 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000003256 228.0
HKD2_k127_2693513_6 AzlC protein - - - 0.00000000000000000000000000000000000000000000000000000000004414 211.0
HKD2_k127_2693513_7 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000001442 218.0
HKD2_k127_2693513_8 ABC transporter K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000000000004317 204.0
HKD2_k127_2693513_9 DegV family - - - 0.00000000000000000000000000000000000000000000000004317 192.0
HKD2_k127_2706077_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.018e-233 751.0
HKD2_k127_2706077_1 Fungal trichothecene efflux pump (TRI12) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001486 428.0
HKD2_k127_2706077_2 ATPases associated with a variety of cellular activities K09812 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004153 278.0
HKD2_k127_2706077_3 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.00000000000000000000000000000000000000000000113 171.0
HKD2_k127_2706077_4 Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation K09811 - - 0.000000000000000000000000000000000000000005563 170.0
HKD2_k127_2706077_5 SH3, type 3 domain protein - - - 0.0000000000000000000000000001276 132.0
HKD2_k127_2710374_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001835 469.0
HKD2_k127_2710374_1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000009105 206.0
HKD2_k127_2710374_2 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000001384 130.0
HKD2_k127_2710374_3 protein histidine kinase activity - - - 0.000000000000000000000007529 113.0
HKD2_k127_2710374_4 - - - - 0.000000000000000006994 94.0
HKD2_k127_2710374_5 photoreceptor activity - - - 0.0000000000002618 84.0
HKD2_k127_2723496_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 4.015e-244 763.0
HKD2_k127_2723496_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 405.0
HKD2_k127_2723496_10 Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities K01782 GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 0.0000000000000000000000000002367 117.0
HKD2_k127_2723496_11 - - - - 0.000000000000000000000000001764 125.0
HKD2_k127_2723496_12 - - - - 0.000000000004163 78.0
HKD2_k127_2723496_13 transcriptional - - - 0.000002294 56.0
HKD2_k127_2723496_14 Two component, sigma54 specific, transcriptional regulator, Fis family K07712 - - 0.000008623 55.0
HKD2_k127_2723496_2 carboxylase K01965,K01968 - 6.4.1.3,6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000172 288.0
HKD2_k127_2723496_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007901 280.0
HKD2_k127_2723496_4 PFAM Enoyl-CoA hydratase isomerase K13766,K15312 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000001166 233.0
HKD2_k127_2723496_5 Bacterial capsule synthesis protein PGA_cap K07282,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000003119 203.0
HKD2_k127_2723496_6 Sodium:sulfate symporter transmembrane region - - - 0.000000000000000000000000000000000000000000001088 187.0
HKD2_k127_2723496_7 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000003782 151.0
HKD2_k127_2723496_8 cyclic nucleotide binding K01420,K10914 - - 0.000000000000000000000000000000001789 139.0
HKD2_k127_2723496_9 MaoC domain protein dehydratase K00634,K17865 - 2.3.1.19,4.2.1.55 0.000000000000000000000000000000038 129.0
HKD2_k127_2730156_0 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 2.145e-289 900.0
HKD2_k127_2730156_1 AMP-binding enzyme C-terminal domain K08295 - 6.2.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003191 565.0
HKD2_k127_2730156_2 Coenzyme A transferase K01039 - 2.8.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002393 353.0
HKD2_k127_2730156_3 Coenzyme A transferase K01040 - 2.8.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006806 322.0
HKD2_k127_2730156_4 very-long-chain-acyl-CoA dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000001124 248.0
HKD2_k127_2730156_5 Enoyl-CoA hydratase/isomerase - - - 0.00000000000000000000000000000000000000000000001173 176.0
HKD2_k127_2730156_6 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000001895 153.0
HKD2_k127_2730156_8 Belongs to the enoyl-CoA hydratase isomerase family K01692 GO:0003674,GO:0003824,GO:0004300,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0030312,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 4.2.1.17 0.00000000007374 64.0
HKD2_k127_2742239_0 glycyl-tRNA aminoacylation K01880 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004166 518.0
HKD2_k127_2742239_1 Belongs to the PEP-utilizing enzyme family K01006 - 2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008475 452.0
HKD2_k127_2742239_2 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - 0.0000000000000000000000000000000000000000000000004971 185.0
HKD2_k127_2742239_3 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000006312 131.0
HKD2_k127_2742239_4 - - - - 0.0000000000000000001268 98.0
HKD2_k127_2742239_5 Putative Actinobacterial Holin-X, holin superfamily III - - - 0.000001277 56.0
HKD2_k127_2745459_0 exonuclease of the beta-lactamase fold involved in RNA K07576 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002961 369.0
HKD2_k127_2745459_1 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000005116 190.0
HKD2_k127_2745459_2 FecR protein - - - 0.00002448 57.0
HKD2_k127_2746104_0 Succinyl-CoA ligase like flavodoxin domain - - - 2.362e-282 895.0
HKD2_k127_2746104_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 5.577e-236 741.0
HKD2_k127_2746104_2 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00122,K00335 - 1.17.1.9,1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007328 573.0
HKD2_k127_2746104_3 Belongs to the alpha-IPM synthase homocitrate synthase family K01655 - 2.3.3.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006334 506.0
HKD2_k127_2746104_4 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004144 441.0
HKD2_k127_2746104_5 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16792 - 4.2.1.114 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007962 425.0
HKD2_k127_2746104_6 2Fe-2S iron-sulfur cluster binding domain K00336 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001583 358.0
HKD2_k127_2746104_7 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K16793 - 4.2.1.114 0.0000000000000000000000000000000000000000000000000002513 193.0
HKD2_k127_2746104_8 Molydopterin dinucleotide binding domain K00123 - 1.17.1.9 0.00000000000000000000000000133 113.0
HKD2_k127_2746104_9 Domain of unknown function DUF11 - - - 0.000000000003412 79.0
HKD2_k127_293117_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1054.0
HKD2_k127_293117_1 succinate dehydrogenase, flavoprotein subunit K00239 GO:0000104,GO:0000166,GO:0001539,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006091,GO:0006113,GO:0006928,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0022607,GO:0022900,GO:0030030,GO:0030031,GO:0032991,GO:0033554,GO:0036094,GO:0040011,GO:0043167,GO:0043168,GO:0044085,GO:0044237,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044780,GO:0044781,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0048037,GO:0048870,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051674,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0070925,GO:0071840,GO:0071944,GO:0071949,GO:0071973,GO:0097159,GO:0097588,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363 1.3.5.1,1.3.5.4 6.149e-268 837.0
HKD2_k127_293117_10 Isocitrate/isopropylmalate dehydrogenase K00030 - 1.1.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000002265 264.0
HKD2_k127_293117_11 Ion channel K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006539 267.0
HKD2_k127_293117_12 membrane - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004608 257.0
HKD2_k127_293117_13 Cytochrome b(C-terminal)/b6/petD - - - 0.0000000000000000000000000000000000000000000000002215 186.0
HKD2_k127_293117_14 Shikimate kinase - - - 0.00000000000000000000000000000000000000000000001869 178.0
HKD2_k127_293117_15 - - - - 0.00000000000000000000000000000000000000000000007367 183.0
HKD2_k127_293117_16 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 0.00000000000000000000000000000000000000005165 166.0
HKD2_k127_293117_17 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000003289 154.0
HKD2_k127_293117_18 Flagellar regulatory protein FleQ - - - 0.00000000000000000000000001101 116.0
HKD2_k127_293117_19 translation initiation inhibitor, yjgF family - - - 0.00000000000000000000000001527 120.0
HKD2_k127_293117_2 'glutamate synthase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009457 432.0
HKD2_k127_293117_20 PFAM Isoprenylcysteine carboxyl methyltransferase - - - 0.0000000000000000000000009205 108.0
HKD2_k127_293117_21 Protein of unknown function (DUF402) - - - 0.00000000000000000001318 97.0
HKD2_k127_293117_22 PFAM Rieske 2Fe-2S domain K02636 - 1.10.9.1 0.00000000000000003737 90.0
HKD2_k127_293117_23 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000006936 93.0
HKD2_k127_293117_3 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K00240 - 1.3.5.1,1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007469 391.0
HKD2_k127_293117_4 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007289 392.0
HKD2_k127_293117_5 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 362.0
HKD2_k127_293117_6 Cytochrome b(N-terminal)/b6/petB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007691 339.0
HKD2_k127_293117_7 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 369.0
HKD2_k127_293117_8 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009881 345.0
HKD2_k127_293117_9 Transcriptional regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002617 286.0
HKD2_k127_296388_0 PFAM Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 430.0
HKD2_k127_296388_1 PFAM isocitrate isopropylmalate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009234 428.0
HKD2_k127_296388_2 PFAM Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001001 319.0
HKD2_k127_296388_3 spore germination K03298 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001716 249.0
HKD2_k127_296388_4 PFAM Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000002126 193.0
HKD2_k127_296388_5 Peptidase A4 family - - - 0.0000000000000000000004593 110.0
HKD2_k127_2990677_0 Catalyzes the transfer of the amino group of L-glutamate to LysW -aminoadipate 6-semialdehyde, generating LysW -gamma-L- lysine K05830 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003759 435.0
HKD2_k127_2990677_1 Catalyzes the NADPH-dependent reduction of LysW - aminoadipate 6-phosphate to yield LysW -aminoadipate 6- semialdehyde K05829 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007892 295.0
HKD2_k127_2990677_10 HD domain - - - 0.0000000000000000000000000000007775 127.0
HKD2_k127_2990677_11 Protein of unknown function with PCYCGC motif - - - 0.000000000000000000006975 100.0
HKD2_k127_2990677_12 GTP cyclohydrolase I - - - 0.00000000000000000001846 100.0
HKD2_k127_2990677_13 exo-alpha-(2->6)-sialidase activity - - - 0.0000000004461 71.0
HKD2_k127_2990677_14 GGDEF domain K02488 - 2.7.7.65 0.0000001551 58.0
HKD2_k127_2990677_15 Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure - - - 0.0000001658 55.0
HKD2_k127_2990677_2 Catalyzes the release of L-lysine from LysW -gamma-L- lysine K05831 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005101 296.0
HKD2_k127_2990677_3 metal-dependent phosphohydrolase HD region - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002244 296.0
HKD2_k127_2990677_4 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005043 254.0
HKD2_k127_2990677_5 Belongs to the acetylglutamate kinase family. LysZ subfamily K05828 GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.00000000000000000000000000000000000000000000000000000000000000000004218 239.0
HKD2_k127_2990677_6 beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000007266 238.0
HKD2_k127_2990677_7 CHASE2 K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000002775 252.0
HKD2_k127_2990677_8 membrane - - - 0.00000000000000000000000000000000000000000000000001874 190.0
HKD2_k127_2990677_9 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000012 155.0
HKD2_k127_3026105_0 Penicillin-binding Protein dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 389.0
HKD2_k127_3026105_1 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009164 338.0
HKD2_k127_3026105_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000003933 206.0
HKD2_k127_3026105_3 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.0000000000000000000000000000000415 130.0
HKD2_k127_3026105_4 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000001421 70.0
HKD2_k127_309496_0 lipid A export permease ATP-binding protein MsbA K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002936 514.0
HKD2_k127_309496_1 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine K11717 - 2.8.1.7,4.4.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007432 473.0
HKD2_k127_309496_10 Belongs to the ABC transporter superfamily K02032,K10823 - - 0.0000000000000002969 78.0
HKD2_k127_309496_11 Multicopper - - - 0.000000000000007316 82.0
HKD2_k127_309496_2 PFAM ABC transporter related K09013 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 333.0
HKD2_k127_309496_3 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001127 288.0
HKD2_k127_309496_4 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004381 283.0
HKD2_k127_309496_5 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.00000000000000000000000000000000000000000000000000000000000000000001207 253.0
HKD2_k127_309496_6 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000003278 242.0
HKD2_k127_309496_7 endonuclease III - - - 0.00000000000000000000000000000000000000000000000000001473 196.0
HKD2_k127_309496_8 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions - - - 0.000000000000000000000000000000000005158 145.0
HKD2_k127_309496_9 transcriptional regulator, Rrf2 family - - - 0.000000000000000000000000000000002459 141.0
HKD2_k127_3115563_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002336 601.0
HKD2_k127_3115563_1 Amidohydrolase family K06015 - 3.5.1.81 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 509.0
HKD2_k127_3115563_10 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.00000000000000000000000000000000002025 145.0
HKD2_k127_3115563_11 PFAM response regulator receiver K02282 - - 0.00000000000000000000000000000000004843 148.0
HKD2_k127_3115563_12 methyltransferase K21459 - 2.1.1.301 0.0000000000000000000000000000000001162 143.0
HKD2_k127_3115563_13 PFAM Major Facilitator Superfamily - - - 0.0000000000000000000000000002775 132.0
HKD2_k127_3115563_14 COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain K10039 - - 0.000000000000000000000002997 113.0
HKD2_k127_3115563_15 Lanthionine synthetase C family protein - - - 0.00000000000000000000007297 109.0
HKD2_k127_3115563_16 PD-(D/E)XK nuclease superfamily - - - 0.0000000000001108 77.0
HKD2_k127_3115563_17 SMART HNH nuclease - - - 0.000000000008288 73.0
HKD2_k127_3115563_18 Protein of unknown function (DUF1461) - - - 0.0000000009108 70.0
HKD2_k127_3115563_2 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003596 355.0
HKD2_k127_3115563_3 Peptidase dimerisation domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001439 322.0
HKD2_k127_3115563_4 Mandelate racemase / muconate lactonizing enzyme, C-terminal domain K19802 - 5.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000009125 260.0
HKD2_k127_3115563_5 Provides the (R)-glutamate required for cell wall biosynthesis K01776,K02428 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 3.6.1.66,5.1.1.3 0.0000000000000000000000000000000000000000000000000000000000000000009922 236.0
HKD2_k127_3115563_6 Domain of unknown function (DUF1611_N) Rossmann-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000001354 248.0
HKD2_k127_3115563_7 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K00760,K04075 - 2.4.2.8,6.3.4.19 0.00000000000000000000000000000000000000000000000000000639 207.0
HKD2_k127_3115563_8 RmuC family K09760 - - 0.000000000000000000000000000000000000000000000006539 194.0
HKD2_k127_3115563_9 PFAM PfkB domain protein - - - 0.00000000000000000000000000000000001465 152.0
HKD2_k127_3118048_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 4.2.1.33,4.2.1.35 3.2e-211 669.0
HKD2_k127_3118048_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002873 346.0
HKD2_k127_3118048_2 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000001022 227.0
HKD2_k127_3118048_3 G5 domain protein K21688 - - 0.00000000000004113 72.0
HKD2_k127_3118048_4 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000004012 66.0
HKD2_k127_3120543_0 F420-0:Gamma-glutamyl ligase K12234 - 6.3.2.31,6.3.2.34 0.000000000000000000000000000000000000000000000000000000000000000000000000000004299 269.0
HKD2_k127_3120543_1 SIS domain K00820 - 2.6.1.16 0.00000000000000000000000000000000000000000000000000000000000006624 227.0
HKD2_k127_3120543_10 DinB family - - - 0.0000000000000000002683 98.0
HKD2_k127_3120543_11 DinB family - - - 0.00000000000000001481 94.0
HKD2_k127_3120543_12 Acetyltransferase (GNAT) domain - - - 0.000000002249 68.0
HKD2_k127_3120543_13 Acetyltransferase (GNAT) family - - - 0.000000551 61.0
HKD2_k127_3120543_14 PFAM helix-turn-helix domain protein - - - 0.00005568 52.0
HKD2_k127_3120543_2 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000001273 207.0
HKD2_k127_3120543_3 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000007543 196.0
HKD2_k127_3120543_4 lactoylglutathione lyase activity - - - 0.00000000000000000000000000000000000000000001993 168.0
HKD2_k127_3120543_5 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000000000001202 145.0
HKD2_k127_3120543_6 PFAM LmbE family protein K18455 - 3.5.1.115 0.0000000000000000000000000000000000335 145.0
HKD2_k127_3120543_7 pyridoxamine 5'-phosphate K07005 - - 0.0000000000000000000000000000001609 133.0
HKD2_k127_3120543_8 Pyridoxamine 5'-phosphate oxidase - - - 0.0000000000000000000000000000333 131.0
HKD2_k127_3120543_9 PFAM Uncharacterised BCR, COG1649 - - - 0.0000000000000000000001134 106.0
HKD2_k127_3136585_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 1.082e-195 624.0
HKD2_k127_3136585_1 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004561 477.0
HKD2_k127_3136585_2 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000223 228.0
HKD2_k127_3136585_3 Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides K03478 - 3.5.1.105 0.000000000000000000000000006502 119.0
HKD2_k127_3136585_4 Methyltransferase domain K00568 - 2.1.1.222,2.1.1.64 0.000000000000000000001112 109.0
HKD2_k127_3136585_5 SMART helix-turn-helix domain protein - - - 0.00000000000000002811 94.0
HKD2_k127_3136585_6 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000001036 84.0
HKD2_k127_31406_0 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001398 363.0
HKD2_k127_31406_1 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 - 2.7.1.33 0.0000000000000000000000000000000000000000000000000000000000000000000000000001683 263.0
HKD2_k127_31406_2 Glycosyl hydrolases family 43 K01209 - 3.2.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000002548 248.0
HKD2_k127_31406_3 Transmembrane secretion effector - - - 0.000000000000000000000000000000000000000000000000000000000000002187 237.0
HKD2_k127_31406_4 integral membrane protein - - - 0.0000000000000000000000000000000000000001043 166.0
HKD2_k127_31406_5 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000001294 152.0
HKD2_k127_31406_6 Prolyl oligopeptidase family - - - 0.00000000000000000000000000000000257 140.0
HKD2_k127_31406_7 Acetyltransferase (GNAT) family - - - 0.00001163 56.0
HKD2_k127_3232517_0 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686,K05516 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003625 379.0
HKD2_k127_3232517_1 SMART Metal-dependent phosphohydrolase, HD region K07037 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 376.0
HKD2_k127_3232517_10 Ribosomal protein S21 K02970 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000004637 79.0
HKD2_k127_3232517_11 Urate oxidase N-terminal - - - 0.00004319 48.0
HKD2_k127_3232517_2 phosphate starvation-inducible protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 337.0
HKD2_k127_3232517_3 Methylates ribosomal protein L11 K02687 - - 0.00000000000000000000000000000000000000000000000000000001033 209.0
HKD2_k127_3232517_4 Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000003713 140.0
HKD2_k127_3232517_5 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.000000000000000000000000000000001167 142.0
HKD2_k127_3232517_6 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.00000000000000000000000000001885 135.0
HKD2_k127_3232517_7 Yqey-like protein K09117 - - 0.00000000000000000000000000001933 124.0
HKD2_k127_3232517_8 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K01489,K03474,K03595,K07042 GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.6.99.2,3.5.4.5 0.00000000000000000001837 96.0
HKD2_k127_3232517_9 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000009276 95.0
HKD2_k127_3243080_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000807 626.0
HKD2_k127_3243080_1 SAICAR synthetase K01923 - 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 387.0
HKD2_k127_3243080_2 adenylosuccinate lyase K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003402 272.0
HKD2_k127_3243080_3 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000005436 267.0
HKD2_k127_3243080_4 Protein of unknown function DUF86 - - - 0.00000000000000000000000000000000000000000000000000000000000000000006666 240.0
HKD2_k127_3243080_5 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000007554 79.0
HKD2_k127_3243080_6 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 GO:0008150,GO:0040007 2.4.2.14 0.0000000004038 68.0
HKD2_k127_336500_0 PFAM DoxX K16937 - 1.8.5.2 0.00000000000000000000000000000000000000000000000000000000000000000000009581 245.0
HKD2_k127_336500_1 Belongs to the NiCoT transporter (TC 2.A.52) family K07241 - - 0.00000000000000000000000000000000000000000000000000000000000000001475 234.0
HKD2_k127_336500_10 Ferric uptake regulator family K03711 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010035,GO:0010038,GO:0010043,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032991,GO:0032993,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046872,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000001527 90.0
HKD2_k127_336500_11 Histidine kinase - - - 0.0000006233 61.0
HKD2_k127_336500_12 domain, Protein K11904,K12132 - 2.7.11.1 0.000219 53.0
HKD2_k127_336500_2 ABC 3 transport family K09819 - - 0.000000000000000000000000000000000000000000000000000000000000002473 228.0
HKD2_k127_336500_3 Belongs to the bacterial solute-binding protein 9 family K09815,K09818 - - 0.00000000000000000000000000000000000000000000000000002924 202.0
HKD2_k127_336500_4 ABC transporter K11710,K19973 - 3.6.3.35 0.00000000000000000000000000000000000000000000000003823 192.0
HKD2_k127_336500_5 Short repeat of unknown function (DUF308) - - - 0.000000000000000000000000000000000000000005623 162.0
HKD2_k127_336500_6 - - - - 0.00000000000000000000000000000008649 132.0
HKD2_k127_336500_7 CopC domain K14166 - - 0.000000000000000000000000000001156 140.0
HKD2_k127_336500_8 Ferric uptake regulator family K03711,K09825 - - 0.00000000000000000000000001943 115.0
HKD2_k127_336500_9 Cytochrome c K07245,K14166 - - 0.00000000000000000001357 100.0
HKD2_k127_3381992_0 PFAM ABC transporter related - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004075 381.0
HKD2_k127_3381992_1 peptidase K01303 - 3.4.19.1 0.000000000000000000000000000000000000000000000000000000000000000001325 231.0
HKD2_k127_3381992_2 - - - - 0.000000000000000000000000000000003443 138.0
HKD2_k127_3381992_3 FR47-like protein - - - 0.0000000000000000000000000000001115 132.0
HKD2_k127_3381992_4 - - - - 0.00000000000000000004539 102.0
HKD2_k127_3381992_5 Ion transport 2 domain protein K10716 - - 0.0000000001683 71.0
HKD2_k127_3381992_6 - - - - 0.00000117 59.0
HKD2_k127_3414222_0 Dehydrogenase E1 component K00615 - 2.2.1.1 1.472e-215 686.0
HKD2_k127_3414222_1 PFAM Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001534 554.0
HKD2_k127_3414222_10 - - - - 0.000000008819 65.0
HKD2_k127_3414222_2 Serine dehydrogenase proteinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 370.0
HKD2_k127_3414222_3 PFAM aminotransferase class V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004157 276.0
HKD2_k127_3414222_4 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.000000000000000000000000000000000000000000000000000000006165 209.0
HKD2_k127_3414222_5 ABC-type Fe3 transport system, periplasmic component K02012 - - 0.0000000000000000000000000000000000000000000000001491 190.0
HKD2_k127_3414222_6 PFAM alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000008238 165.0
HKD2_k127_3414222_7 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000008204 154.0
HKD2_k127_3414222_8 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000009312 118.0
HKD2_k127_3414222_9 metal-dependent membrane protease K07052 - - 0.000000002141 70.0
HKD2_k127_3417355_0 Toxic component of a toxin-antitoxin (TA) module. An RNase - - - 0.00000000000000000000003164 108.0
HKD2_k127_3417355_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000001308 102.0
HKD2_k127_3417355_2 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000004564 65.0
HKD2_k127_3417355_3 positive regulation of growth - - - 0.000005458 52.0
HKD2_k127_3560886_0 collagen metabolic process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 492.0
HKD2_k127_3560886_1 Phosphate transporter family K03306 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 383.0
HKD2_k127_3560886_2 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001074 315.0
HKD2_k127_3560886_3 Required for morphogenesis under gluconeogenic growth conditions - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002205 286.0
HKD2_k127_3560886_4 Belongs to the peptidase S8 family K17734 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007229 276.0
HKD2_k127_3560886_5 response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000003891 225.0
HKD2_k127_3560886_6 Protein of unknown function DUF47 K07220 - - 0.00000000000000000000000000000000000000000002342 168.0
HKD2_k127_3560886_7 FecR protein - - - 0.0000000000002428 80.0
HKD2_k127_3560886_8 FecR protein - - - 0.000000000001864 76.0
HKD2_k127_357516_0 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 6.974e-211 671.0
HKD2_k127_357516_1 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000134 452.0
HKD2_k127_357516_10 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000000000000000000000000003263 222.0
HKD2_k127_357516_11 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000003422 222.0
HKD2_k127_357516_12 Belongs to the FPP GGPP synthase family K13787 - 2.5.1.1,2.5.1.10,2.5.1.29 0.0000000000000000000000000000000000000000000000000000000000008683 219.0
HKD2_k127_357516_13 TIGRFAM UTP--glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000002251 226.0
HKD2_k127_357516_14 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.0000000000000000000000000000000000000000000000000000000001074 213.0
HKD2_k127_357516_15 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.00000000000000000000000000000000000000000000000000000002787 208.0
HKD2_k127_357516_16 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000009268 200.0
HKD2_k127_357516_17 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.000000000000000000000000000000000000000000000000000005642 195.0
HKD2_k127_357516_18 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000005575 192.0
HKD2_k127_357516_19 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000000004328 186.0
HKD2_k127_357516_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006512 425.0
HKD2_k127_357516_20 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000000000000002286 181.0
HKD2_k127_357516_21 This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis K01489 - 3.5.4.5 0.000000000000000000000000000000000005604 142.0
HKD2_k127_357516_22 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.000000000000000000000000000000000009895 153.0
HKD2_k127_357516_23 Belongs to the universal ribosomal protein uS9 family K02996 - - 0.00000000000000000000000000000000001664 145.0
HKD2_k127_357516_24 binds to the 23S rRNA K02876 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - 0.000000000000000000000000000000000139 141.0
HKD2_k127_357516_25 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065 - 0.0000000000000000000000000000061 121.0
HKD2_k127_357516_26 YbbR-like protein - GO:0008150,GO:0031279,GO:0031281,GO:0043085,GO:0044093,GO:0045761,GO:0045762,GO:0050790,GO:0051339,GO:0051349,GO:0065007,GO:0065009 - 0.00000000000000000000000000001374 136.0
HKD2_k127_357516_27 ribosomal protein l17 K02879 - - 0.000000000000000000000000001981 119.0
HKD2_k127_357516_28 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00000000000000000000000377 117.0
HKD2_k127_357516_29 domain protein K21688 GO:0005575,GO:0005576,GO:0008150,GO:0009892,GO:0009893,GO:0010468,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019222,GO:0022611,GO:0032502,GO:0040008,GO:0040009,GO:0040010,GO:0044111,GO:0044114,GO:0044115,GO:0044403,GO:0044419,GO:0045927,GO:0048518,GO:0048519,GO:0050789,GO:0051704,GO:0060255,GO:0065007,GO:0085016 - 0.000000000000001778 88.0
HKD2_k127_357516_3 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008038 389.0
HKD2_k127_357516_31 HNH endonuclease - - - 0.000000000001598 75.0
HKD2_k127_357516_32 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.00000000003843 63.0
HKD2_k127_357516_33 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000002225 55.0
HKD2_k127_357516_34 ribosomal protein L30 K02907 - - 0.00000005106 63.0
HKD2_k127_357516_35 Bacterial PH domain - - - 0.000001354 59.0
HKD2_k127_357516_36 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00006071 55.0
HKD2_k127_357516_4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 340.0
HKD2_k127_357516_5 Immune inhibitor A peptidase M6 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003353 362.0
HKD2_k127_357516_6 Methionine aminopeptidase K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000907 304.0
HKD2_k127_357516_7 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000014 285.0
HKD2_k127_357516_8 CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000123 272.0
HKD2_k127_357516_9 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004287 243.0
HKD2_k127_3805671_0 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K05365 - 2.4.1.129,3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 462.0
HKD2_k127_3805671_1 pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity K06215 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016829,GO:0016840,GO:0016843,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0040007,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.3.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006479 282.0
HKD2_k127_3805671_10 DNA polymerase III, delta subunit K02341 - 2.7.7.7 0.000000000000000000000000000000000000004059 159.0
HKD2_k127_3805671_11 AAA ATPase K07478 - - 0.0000000000000000000000000000004242 125.0
HKD2_k127_3805671_12 Transglycosylase associated protein - - - 0.00000000000000000001152 96.0
HKD2_k127_3805671_13 transcriptional regulator K03892 - - 0.0000000000000000000345 94.0
HKD2_k127_3805671_2 ATPase domain predominantly from Archaea K06921 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005486 283.0
HKD2_k127_3805671_3 Methyltransferase type 11 K07755 - 2.1.1.137 0.00000000000000000000000000000000000000000000000000000000000000001971 237.0
HKD2_k127_3805671_4 Belongs to the FPP GGPP synthase family K00805 - 2.5.1.30 0.00000000000000000000000000000000000000000000000000000002426 209.0
HKD2_k127_3805671_5 PFAM PSP1 domain protein - - - 0.00000000000000000000000000000000000000000000000000000003765 212.0
HKD2_k127_3805671_6 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes K03118 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.00000000000000000000000000000000000000000000000000001681 196.0
HKD2_k127_3805671_7 HNH endonuclease - - - 0.00000000000000000000000000000000000000000000000000006236 191.0
HKD2_k127_3805671_8 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000005297 205.0
HKD2_k127_3805671_9 transferase activity, transferring glycosyl groups - - - 0.0000000000000000000000000000000000000000002345 172.0
HKD2_k127_3852453_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 8.605e-311 975.0
HKD2_k127_3852453_1 Histidine kinase - - - 0.000004655 57.0
HKD2_k127_3865307_0 tRNA binding K04566 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002073 417.0
HKD2_k127_3865307_1 C-terminal binding-module, SLH-like, of glucodextranase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001598 410.0
HKD2_k127_3865307_2 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000006491 160.0
HKD2_k127_3865307_3 FES K03575 - - 0.0000000000000000000000000000000000000008034 151.0
HKD2_k127_3866370_0 Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 472.0
HKD2_k127_3866370_1 Bacterial DNA topoisomeraes I ATP-binding domain K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002811 299.0
HKD2_k127_3866370_2 PFAM Methicillin resistance protein - - - 0.00000000000000000000000000000000000000000000003439 183.0
HKD2_k127_3866370_3 PFAM Methicillin resistance protein - - - 0.00000000000000000000000000000000000000009775 171.0
HKD2_k127_3866370_4 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000007686 96.0
HKD2_k127_3866370_5 AAA domain K07028 - - 0.00000000000004697 86.0
HKD2_k127_3866727_0 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008948 358.0
HKD2_k127_3866727_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002768 346.0
HKD2_k127_3866727_2 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 296.0
HKD2_k127_3866727_3 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000144 255.0
HKD2_k127_3866727_4 D-aminopeptidase K16203 - - 0.000000000000000000000000000000000000000000000000000000000000001852 229.0
HKD2_k127_3866727_5 Mate efflux family protein - - - 0.00000000000000000000000000000000000000000000000000000009194 213.0
HKD2_k127_3866727_6 Participates in initiation and elongation during chromosome replication - - - 0.000000007086 66.0
HKD2_k127_3866727_7 Preprotein translocase SecG subunit K03075 - - 0.000003423 59.0
HKD2_k127_3944605_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1368.0
HKD2_k127_3944605_1 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004021 554.0
HKD2_k127_3944605_10 glycine decarboxylation via glycine cleavage system K02437 - - 0.000000000000000000000000000000000000000001379 167.0
HKD2_k127_3944605_11 PFAM Cupin 2, conserved barrel - - - 0.00000000000000000000000000000001158 132.0
HKD2_k127_3944605_12 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363 - 0.0000000000000000000000000000008063 127.0
HKD2_k127_3944605_13 F420H(2)-dependent quinone reductase - - - 0.00000000000000000001885 104.0
HKD2_k127_3944605_14 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000000005051 93.0
HKD2_k127_3944605_15 - - - - 0.0000000000002089 80.0
HKD2_k127_3944605_16 Dienelactone hydrolase family - - - 0.00000125 61.0
HKD2_k127_3944605_2 Fe-S oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 496.0
HKD2_k127_3944605_3 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009107 400.0
HKD2_k127_3944605_4 Lipoate-protein ligase K03800 - 6.3.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005212 338.0
HKD2_k127_3944605_5 PFAM Electron transfer flavoprotein domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007425 282.0
HKD2_k127_3944605_6 Fe-S oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000005241 197.0
HKD2_k127_3944605_7 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000000000004872 183.0
HKD2_k127_3944605_8 DsrE/DsrF/DrsH-like family - - - 0.000000000000000000000000000000000000000000000005519 178.0
HKD2_k127_3944605_9 Rieske [2Fe-2S] domain - - - 0.000000000000000000000000000000000000000000000353 175.0
HKD2_k127_3956644_0 Proline racemase K01777 GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016855,GO:0018112,GO:0019752,GO:0036361,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0050346,GO:0071704,GO:1901564 5.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000212 446.0
HKD2_k127_3956644_1 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001458 387.0
HKD2_k127_3956644_2 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000009235 247.0
HKD2_k127_3956644_3 reductase - - - 0.000000000000000000000000000000000000000000000000000000000000000001106 239.0
HKD2_k127_3956644_4 Signal peptidase, peptidase S26 K03100 - 3.4.21.89 0.0000000000000000000000000000007182 128.0
HKD2_k127_3956644_5 - - - - 0.000000000000000004905 95.0
HKD2_k127_3968266_0 PFAM type II secretion system protein E K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 591.0
HKD2_k127_3968266_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 559.0
HKD2_k127_3968266_10 GTP binding - - - 0.0000000000000000000000000000000000000000000000000688 192.0
HKD2_k127_3968266_11 Phosphotransferase enzyme family - - - 0.0000000000000000000000000000000000000005276 162.0
HKD2_k127_3968266_12 Uncharacterized ACR, COG1430 K09005 - - 0.000000000000000000000000001094 119.0
HKD2_k127_3968266_13 Competence protein - - - 0.00000000000000000000000002027 116.0
HKD2_k127_3968266_14 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000708 116.0
HKD2_k127_3968266_15 RDD family - - - 0.0000000000000000000002271 101.0
HKD2_k127_3968266_16 Peptidase A24A, prepilin type IV K02278 - 3.4.23.43 0.0000000000001615 77.0
HKD2_k127_3968266_17 DNA polymerase alpha chain like domain K04477 - - 0.0000001695 64.0
HKD2_k127_3968266_18 PFAM Flp Fap pilin component K02651 - - 0.0001799 49.0
HKD2_k127_3968266_2 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004481 510.0
HKD2_k127_3968266_3 PFAM response regulator receiver K02282 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 389.0
HKD2_k127_3968266_4 Major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001749 328.0
HKD2_k127_3968266_5 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 311.0
HKD2_k127_3968266_6 ATPases associated with a variety of cellular activities K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009899 308.0
HKD2_k127_3968266_7 ABC-type multidrug transport system, permease component K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007368 265.0
HKD2_k127_3968266_8 Type II secretion system (T2SS), protein F K12510 - - 0.000000000000000000000000000000000000000000000000000000000000000004004 239.0
HKD2_k127_3968266_9 Type II secretion system (T2SS), protein F K12511 - - 0.0000000000000000000000000000000000000000000000000000005773 203.0
HKD2_k127_3994076_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 2.037e-251 791.0
HKD2_k127_3994076_1 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone K00036 - 1.1.1.363,1.1.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 615.0
HKD2_k127_3994076_2 6-phosphogluconate dehydrogenase, C-terminal domain K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006943 413.0
HKD2_k127_3994076_3 Serine/Threonine protein kinases, catalytic domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000001153 224.0
HKD2_k127_3994076_4 C-terminal four TMM region of protein-O-mannosyltransferase K00728 - 2.4.1.109 0.0000000000000000000000000000000000000000000000000000002276 223.0
HKD2_k127_3994076_5 Glucose-6-phosphate dehydrogenase subunit - - - 0.000000000000000000000000000000000000002113 168.0
HKD2_k127_3994076_6 LemA family K03744 - - 0.000000000000000000000000000002963 123.0
HKD2_k127_3994076_7 Sigma factor PP2C-like phosphatases K20074 - 3.1.3.16 0.00000000000000000000000001707 126.0
HKD2_k127_4040029_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 541.0
HKD2_k127_4040029_1 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001506 329.0
HKD2_k127_4040029_10 PFAM ABC-2 type transporter K01992 - - 0.0000000000000009116 91.0
HKD2_k127_4040029_11 - - - - 0.000005866 54.0
HKD2_k127_4040029_2 Displays ATPase and GTPase activities K06958 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004135 274.0
HKD2_k127_4040029_3 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000008628 184.0
HKD2_k127_4040029_4 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate K15633 - 5.4.2.12 0.000000000000000000000000000000000000005697 156.0
HKD2_k127_4040029_5 Protein of unknown function (DUF2089) - - - 0.0000000000000000000000000000000001477 136.0
HKD2_k127_4040029_6 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000001928 129.0
HKD2_k127_4040029_7 May be required for sporulation K09762 - - 0.000000000000000000002782 109.0
HKD2_k127_4040029_8 PFAM Membrane protein of K08972 - - 0.00000000000000001283 87.0
HKD2_k127_4040029_9 domain, Protein - - - 0.00000000000000009839 93.0
HKD2_k127_405071_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002497 563.0
HKD2_k127_405071_1 Belongs to the phosphoglycerate kinase family K00927 GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 451.0
HKD2_k127_405071_2 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004662 430.0
HKD2_k127_405071_3 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000034 327.0
HKD2_k127_4077587_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 376.0
HKD2_k127_4077587_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000000000000000000000000000000000000004735 169.0
HKD2_k127_4077587_2 carboxymethylenebutenolidase activity K01061 - 3.1.1.45 0.0000000000000004647 90.0
HKD2_k127_4077587_3 - - - - 0.000002732 59.0
HKD2_k127_4095271_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000549 438.0
HKD2_k127_4095271_1 Molybdopterin oxidoreductase Fe4S4 domain K00123 - 1.17.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000009287 251.0
HKD2_k127_4095271_2 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.000000000000000000000000000000000002405 139.0
HKD2_k127_4095271_3 - - - - 0.00000000000007114 78.0
HKD2_k127_4148207_0 peptidase dimerisation domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002667 477.0
HKD2_k127_4148207_1 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002835 465.0
HKD2_k127_4148207_10 membrane - - - 0.00000001933 66.0
HKD2_k127_4148207_2 Cys/Met metabolism PLP-dependent enzyme K01739,K01761 - 2.5.1.48,4.4.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 339.0
HKD2_k127_4148207_3 benzoyl-CoA reductase K04112 - 1.3.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000006117 278.0
HKD2_k127_4148207_4 haloacid dehalogenase - - - 0.0000000000000000000000000000000000000000000001349 186.0
HKD2_k127_4148207_5 Two component transcriptional regulator, winged helix family - - - 0.00000000000000000000000006086 121.0
HKD2_k127_4148207_6 PspC domain - - - 0.000000000000000000000006729 107.0
HKD2_k127_4148207_7 general stress protein B in uncultured methanogenic archaeon (Q0W564) - - - 0.000000000000001832 80.0
HKD2_k127_4148207_8 Acetyltransferase (GNAT) domain - - - 0.000000000003651 72.0
HKD2_k127_4148207_9 Benzoyl-CoA reductase 2-hydroxyglutaryl-CoA dehydratase subunit, BcrC BadD HgdB K04113 - 1.3.7.8 0.00000001169 67.0
HKD2_k127_4166949_0 ABC transporter, transmembrane region K06147 - - 8.671e-242 775.0
HKD2_k127_4166949_1 adenylyl cyclase class-3 4 guanylyl cyclase - - - 3.089e-207 682.0
HKD2_k127_4166949_2 ABC transporter, transmembrane region K06147 - - 1.845e-203 649.0
HKD2_k127_4166949_3 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009773 324.0
HKD2_k127_4166949_4 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.000000000000000000000000000000000000000000000000000000000002319 219.0
HKD2_k127_4166949_5 helix_turn_helix multiple antibiotic resistance protein - - - 0.0000007465 57.0
HKD2_k127_4166949_6 Binds directly to 16S ribosomal RNA K02968 - - 0.000001224 55.0
HKD2_k127_4169942_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 - 2.3.1.29,2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003928 572.0
HKD2_k127_4169942_1 Zinc-binding dehydrogenase K00060 - 1.1.1.103 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001733 507.0
HKD2_k127_4169942_2 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000000000000001026 236.0
HKD2_k127_4169942_3 Aldo/keto reductase family - - - 0.00000000000000000000000000000000000000000000000000000000002182 222.0
HKD2_k127_4169942_4 Amidohydrolase family - - - 0.00000000000000000000000000000000000004177 147.0
HKD2_k127_4169942_5 - - - - 0.000000000000001077 86.0
HKD2_k127_417394_0 PFAM Glycoside hydrolase, family 38 K01191,K15524 - 3.2.1.170,3.2.1.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001083 405.0
HKD2_k127_417394_1 SNARE associated Golgi protein - - - 0.0000000000000000000000000000000000000000000000000000000002626 210.0
HKD2_k127_417394_2 PFAM PAP2 superfamily K19302 - 3.6.1.27 0.0000000000003998 83.0
HKD2_k127_4195015_0 SMART Elongator protein 3 MiaB NifB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004965 511.0
HKD2_k127_4195015_1 Flavodoxin domain K00230 - 1.3.5.3 0.00000000000000000000000000000000000000001105 160.0
HKD2_k127_4195015_2 Cupin 2, conserved barrel domain protein - - - 0.000000000000000000000000000271 123.0
HKD2_k127_4195015_3 PFAM Peptidase M23 K21471 - - 0.000000000000000000000000001467 128.0
HKD2_k127_4195015_4 RDD family - - - 0.00000000000000000000003184 104.0
HKD2_k127_4195015_5 SET domain K07117 - - 0.00000000000000008629 85.0
HKD2_k127_4195015_7 GDP-mannose mannosyl hydrolase activity K03574 - 3.6.1.55 0.0008316 44.0
HKD2_k127_4208621_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00283 - 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001495 560.0
HKD2_k127_4208621_1 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00282 GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204 1.4.4.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001909 364.0
HKD2_k127_4208621_10 DNA-templated transcription, initiation K03088 - - 0.0000000000000000000000000000000006587 140.0
HKD2_k127_4208621_11 Glyoxalase-like domain K05606 - 5.1.99.1 0.00000000000000000000000000000005533 132.0
HKD2_k127_4208621_12 NlpC/P60 family - - - 0.000000000000000000000000000002952 131.0
HKD2_k127_4208621_13 Belongs to the Nudix hydrolase family - - - 0.00000000000000000000000003121 123.0
HKD2_k127_4208621_14 Glycoprotease family K14742 - - 0.000000000000001187 86.0
HKD2_k127_4208621_15 - - - - 0.0000000009233 71.0
HKD2_k127_4208621_16 Carbohydrate kinase - - - 0.0000001774 64.0
HKD2_k127_4208621_2 The glycine cleavage system catalyzes the degradation of glycine K00605 - 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005017 361.0
HKD2_k127_4208621_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004585 332.0
HKD2_k127_4208621_4 Metal dependent phosphohydrolases with conserved 'HD' motif. K09163 - - 0.000000000000000000000000000000000000000000000000000000000000000000002581 245.0
HKD2_k127_4208621_5 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000193 179.0
HKD2_k127_4208621_6 Ribosomal-protein-alanine acetyltransferase K03789 - 2.3.1.128 0.000000000000000000000000000000000000000000002944 171.0
HKD2_k127_4208621_7 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.00000000000000000000000000000000000000000001825 164.0
HKD2_k127_4208621_8 Peptidase C26 K07010 - - 0.000000000000000000000000000000000008024 150.0
HKD2_k127_4208621_9 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000000000000000004891 143.0
HKD2_k127_4233783_0 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009214 475.0
HKD2_k127_4233783_1 Cytochrome c oxidase subunit K02275 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000007491 253.0
HKD2_k127_4233783_2 TatD related DNase K03424 - - 0.00000000000000000000000000000000000000000000000000000000565 207.0
HKD2_k127_4233783_3 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000001227 119.0
HKD2_k127_4233783_4 extracellular polysaccharide biosynthetic process K13582 - - 0.000000000000000000000005076 115.0
HKD2_k127_4233783_5 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000003609 109.0
HKD2_k127_4241773_0 Heat shock 70 kDa protein K04043 - - 8.693e-284 886.0
HKD2_k127_4241773_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001017 275.0
HKD2_k127_4241773_2 ferrous iron binding K06990,K15755 - - 0.0000000000000000000000000000000000000000000000000000000008252 210.0
HKD2_k127_4241773_3 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066 - 0.00000000000000000000000000000000000000002131 157.0
HKD2_k127_4241773_4 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.0000000000000000000000000000000004826 140.0
HKD2_k127_4241773_5 Response regulator receiver K02483,K07658,K07668 - - 0.0000000000000000000000000001442 125.0
HKD2_k127_4241773_6 Cation transport regulator - - - 0.0008329 48.0
HKD2_k127_4270118_0 Dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002233 369.0
HKD2_k127_4270118_1 metal ion transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000000000000000000000003565 235.0
HKD2_k127_4270118_2 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.000000000000000000000000000000000000000000000000000000000001471 226.0
HKD2_k127_4270118_3 Flagellar regulatory protein FleQ - - - 0.0000000000000000000003346 100.0
HKD2_k127_4270118_4 glycosyl transferase group 1 - - - 0.0000000000000003252 89.0
HKD2_k127_4329670_0 Cell division protein FtsA K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 458.0
HKD2_k127_4329670_1 COG2931, RTX toxins and related Ca2 -binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000495 246.0
HKD2_k127_4329670_2 Subtilase family K14743 - - 0.000000000000000000000000000000000000000000000000000000000004032 232.0
HKD2_k127_4329670_3 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000005271 150.0
HKD2_k127_4329670_4 Conserved repeat domain - - - 0.000000000000000000000000001719 130.0
HKD2_k127_4329670_5 O-antigen polymerase K18814 - - 0.0000002366 64.0
HKD2_k127_4378872_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 365.0
HKD2_k127_4378872_1 PFAM aspartate ornithine carbamoyltransferase, Asp Orn-binding region K00609 GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006051 347.0
HKD2_k127_4378872_2 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001546 335.0
HKD2_k127_4378872_3 PFAM Phenazine biosynthesis PhzC PhzF protein K06998 - 5.3.3.17 0.000000000000000000000000000000000000000000000000000000000000004452 227.0
HKD2_k127_4378872_4 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant K02825 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000001917 220.0
HKD2_k127_4378872_5 Peptidase, M23 - - - 0.000000000000000000000000000009348 135.0
HKD2_k127_4386701_0 Psort location CytoplasmicMembrane, score - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 325.0
HKD2_k127_4386701_1 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000001613 60.0
HKD2_k127_4388172_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001037 595.0
HKD2_k127_4388172_1 PFAM CoA-transferase family III K07544,K07749,K18702 - 2.8.3.15,2.8.3.16,2.8.3.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006224 417.0
HKD2_k127_4388172_10 beta-keto acid cleavage enzyme - - - 0.0000000000000000000000000000000000000000000000003356 186.0
HKD2_k127_4388172_11 Kdo2-lipid A biosynthetic process K02517,K22311 - 2.3.1.241,2.3.1.265 0.000000000000000000000000000000000000000000007233 188.0
HKD2_k127_4388172_12 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000002839 166.0
HKD2_k127_4388172_13 SMART phosphoesterase PHP domain protein - - - 0.00000000000000000000000000000000000000002823 162.0
HKD2_k127_4388172_14 MgsA AAA+ ATPase C terminal K07478 - - 0.000000000000000000000000000000008282 129.0
HKD2_k127_4388172_15 Bacterial lipid A biosynthesis acyltransferase K02517,K22311 - 2.3.1.241,2.3.1.265 0.000000000000000000000000000000145 141.0
HKD2_k127_4388172_16 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K00999 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 0.000000000000000000004511 101.0
HKD2_k127_4388172_17 DNA-binding transcription factor activity K03892 - - 0.000000000000002984 83.0
HKD2_k127_4388172_2 PFAM Extracellular ligand-binding receptor K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005133 364.0
HKD2_k127_4388172_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002893 312.0
HKD2_k127_4388172_4 Glycosyl transferases group 1 K08256 - 2.4.1.345 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005363 306.0
HKD2_k127_4388172_5 Belongs to the enoyl-CoA hydratase isomerase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002796 281.0
HKD2_k127_4388172_6 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006991 276.0
HKD2_k127_4388172_7 ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000252 274.0
HKD2_k127_4388172_8 transport system permease K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000006286 239.0
HKD2_k127_4388172_9 ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000002146 245.0
HKD2_k127_4391312_0 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005958 585.0
HKD2_k127_4391312_1 PFAM Exonuclease, RNase T and DNA polymerase III K02342,K03722 - 2.7.7.7,3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004243 540.0
HKD2_k127_4391312_2 PFAM band 7 protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001254 307.0
HKD2_k127_4391312_3 NfeD-like C-terminal, partner-binding K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001705 301.0
HKD2_k127_4391312_4 DNA polymerase Ligase (LigD) K01971,K10747 GO:0000166,GO:0000287,GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0003896,GO:0003899,GO:0003909,GO:0003910,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0004652,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006269,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016874,GO:0016886,GO:0016895,GO:0017076,GO:0018130,GO:0019438,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0033554,GO:0034061,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0070566,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0097747,GO:0140097,GO:0140098,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.0000003944 61.0
HKD2_k127_4391312_5 PFAM Flp Fap pilin component K02651 - - 0.000008581 51.0
HKD2_k127_4391312_6 Pfam:DUF385 - - - 0.0004218 51.0
HKD2_k127_4471700_0 Aminotransferase K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007294 304.0
HKD2_k127_4471700_1 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000004632 218.0
HKD2_k127_4471700_2 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000000001757 184.0
HKD2_k127_4471700_3 Belongs to the arginase family K01476 - 3.5.3.1 0.000000000000000000000000657 118.0
HKD2_k127_4471700_4 Ammonium Transporter K03320 - - 0.00000000004782 63.0
HKD2_k127_4477652_0 5'-3' exonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000007095 267.0
HKD2_k127_4477652_1 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 0.000000000000000000000000000000000000000000000000000000001799 208.0
HKD2_k127_4477652_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000005007 211.0
HKD2_k127_4477652_3 phosphatase homologous to the C-terminal domain of histone macroH2A1 - - - 0.00000000000000000000000000000008163 131.0
HKD2_k127_4477652_4 CAAX protease self-immunity K07052 - - 0.00000000000000000000000007061 115.0
HKD2_k127_4504730_0 PFAM ABC-2 type transporter K01992,K09690 - - 0.0000000000000000000000000000000000000000000000000009062 193.0
HKD2_k127_4504730_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) K01055 - 3.1.1.24 0.00000000000000000000000000007465 126.0
HKD2_k127_4504730_2 Acid phosphatase homologues K19302 - 3.6.1.27 0.0000000000001108 77.0
HKD2_k127_4504730_3 - - - - 0.0000006354 60.0
HKD2_k127_4563109_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1286.0
HKD2_k127_4563109_1 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 4.211e-285 891.0
HKD2_k127_4563109_10 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.00000003567 64.0
HKD2_k127_4563109_2 PFAM ABC transporter related K06158 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007241 406.0
HKD2_k127_4563109_3 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000002915 217.0
HKD2_k127_4563109_4 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - 0.00000000000000000000000000000000000000000000000000009388 197.0
HKD2_k127_4563109_5 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000005313 180.0
HKD2_k127_4563109_6 Cysteine-rich secretory protein family - - - 0.00000000000000000000000000000000000000000001393 174.0
HKD2_k127_4563109_7 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.0000000000000000000000000000000000000001129 157.0
HKD2_k127_4563109_8 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000001877 114.0
HKD2_k127_4563109_9 TadE-like protein - - - 0.00000002512 63.0
HKD2_k127_4600846_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003223 516.0
HKD2_k127_4600846_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000001493 207.0
HKD2_k127_4600846_2 PFAM 60 kDa inner membrane insertion protein K03217 - - 0.0000000000000000000000000000000000000000000000003535 188.0
HKD2_k127_4600846_3 R3H domain protein K06346 - - 0.0000000000000000000000000000000044 138.0
HKD2_k127_4600846_4 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.000000000000000000005741 98.0
HKD2_k127_4600846_5 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.000000000004151 68.0
HKD2_k127_4600846_6 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme K03536 - 3.1.26.5 0.0005631 49.0
HKD2_k127_4658123_0 Belongs to the peptidase S8 family - - - 1.107e-278 891.0
HKD2_k127_4658123_1 ABC transporter - - - 2.29e-238 748.0
HKD2_k127_4658123_2 Peptidase M1 membrane alanine aminopeptidase K01256,K08776 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000421 597.0
HKD2_k127_4658123_3 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 464.0
HKD2_k127_4658123_4 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000448 380.0
HKD2_k127_4658123_5 PFAM Integral membrane protein TerC - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001806 289.0
HKD2_k127_4658185_0 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002124 302.0
HKD2_k127_4658185_1 thymidine kinase K00857 - 2.7.1.21 0.00000000000000000000000000000000000000000000000000000000000000000000009017 243.0
HKD2_k127_4658185_2 Beta-lactamase superfamily domain - - - 0.000000000000000000000000000000000000000000000000000000000009832 216.0
HKD2_k127_4658185_4 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000579 139.0
HKD2_k127_4658185_5 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.00000000000000000000000001085 114.0
HKD2_k127_4658185_6 This protein binds to 23S rRNA in the presence of protein L20 K02888 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - 0.000000000000000000000002068 109.0
HKD2_k127_4658185_7 50S ribosomal protein L31 K02909 - - 0.000000000000000000000004318 109.0
HKD2_k127_4658185_8 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000002802 96.0
HKD2_k127_4658185_9 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000009161 49.0
HKD2_k127_4666661_0 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 317.0
HKD2_k127_4666661_1 Protein of unknown function (DUF2891) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003253 267.0
HKD2_k127_4666661_2 ADP-glyceromanno-heptose 6-epimerase activity - - - 0.000000000000000000000000000000000000000000000000000000003583 206.0
HKD2_k127_4666661_3 Thioesterase - - - 0.0000000000000000000000000000000000005123 151.0
HKD2_k127_47394_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003853 571.0
HKD2_k127_47394_1 Mediates influx of magnesium ions K03284 - - 0.0000000000000000000000000000000000000000000000000000000000008548 222.0
HKD2_k127_47394_2 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000006312 138.0
HKD2_k127_47394_3 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000005784 113.0
HKD2_k127_47394_4 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000002895 91.0
HKD2_k127_47394_5 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.0000000000002119 72.0
HKD2_k127_4745644_0 ATPases associated with a variety of cellular activities K16785,K16786,K16787 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003167 527.0
HKD2_k127_4745644_1 Cobalt transport protein K16785 - - 0.00000000000000000000000000000000000000000001648 172.0
HKD2_k127_4745644_2 ABC-type cobalt transport system, permease component K16925 - - 0.00000000000000000000000000000000000000000002467 177.0
HKD2_k127_4745644_3 PFAM Thiamin pyrophosphokinase, catalytic region K00949 - 2.7.6.2 0.000000000000000000000000000000000000004919 155.0
HKD2_k127_4745644_4 Ammonium transporter K03320 - - 0.00000004314 55.0
HKD2_k127_4745644_5 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.0000003852 63.0
HKD2_k127_490883_0 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000009688 252.0
HKD2_k127_490883_1 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 0.0000000000008661 71.0
HKD2_k127_4950506_0 F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001682 302.0
HKD2_k127_4950506_1 Dienelactone hydrolase family K01061 - 3.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000001628 252.0
HKD2_k127_4950506_2 Domain of unknown function (DUF309) K09763 - - 0.0000000000000000000000000005564 120.0
HKD2_k127_4950506_3 NifU domain protein - - - 0.00000000007249 67.0
HKD2_k127_4965200_0 CoA-transferase family III K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006438 460.0
HKD2_k127_4965200_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002214 461.0
HKD2_k127_4965200_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - - 0.0000000000000000000000000000004271 129.0
HKD2_k127_4965200_11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.3 0.000000000000000000000000000001025 136.0
HKD2_k127_4965200_12 - - - - 0.00000000000000003005 91.0
HKD2_k127_4965200_13 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.0000000004122 62.0
HKD2_k127_4965200_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004307 428.0
HKD2_k127_4965200_3 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002204 414.0
HKD2_k127_4965200_4 Binding-protein-dependent transport system inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 329.0
HKD2_k127_4965200_5 pfkB family carbohydrate kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 327.0
HKD2_k127_4965200_6 Extracellular solute-binding protein K02027 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003468 302.0
HKD2_k127_4965200_7 Binding-protein-dependent transport system inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001244 267.0
HKD2_k127_4965200_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000006915 235.0
HKD2_k127_4965200_9 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit K00334 - 1.6.5.3 0.0000000000000000000000000000001845 128.0
HKD2_k127_49770_0 PFAM Polysulphide reductase, NrfD K00185 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001634 322.0
HKD2_k127_49770_1 PFAM Amidohydrolase family K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002839 304.0
HKD2_k127_49770_2 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003547 274.0
HKD2_k127_49770_3 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000414 261.0
HKD2_k127_49770_4 Transcriptional regulatory protein, C terminal K02483,K07669 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009716 246.0
HKD2_k127_49770_5 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000001699 210.0
HKD2_k127_49770_6 Formiminotransferase domain, N-terminal subdomain K00603,K13990 - 2.1.2.5,4.3.1.4 0.000000000000000000000000000000000000000000000005387 178.0
HKD2_k127_5127694_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 4.069e-223 701.0
HKD2_k127_5127694_1 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases K00174 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003004 613.0
HKD2_k127_5127694_2 2 iron, 2 sulfur cluster binding K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005169 425.0
HKD2_k127_5127694_3 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 335.0
HKD2_k127_5150621_0 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - 1.04e-315 985.0
HKD2_k127_5150621_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333,K13378 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000269 435.0
HKD2_k127_5150621_2 PFAM Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit K00335,K05587 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000008281 257.0
HKD2_k127_5150621_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000006367 245.0
HKD2_k127_5150621_4 Inositol monophosphatase K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000002958 207.0
HKD2_k127_5150621_5 Putative S-adenosyl-L-methionine-dependent methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000002802 222.0
HKD2_k127_5150621_6 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K14091 - 1.6.5.3 0.000000000000000000000000004781 119.0
HKD2_k127_5236811_0 HMGL-like K01640 - 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004717 351.0
HKD2_k127_5236811_1 Acetyl propionyl-CoA carboxylase, alpha subunit K11263 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 6.3.4.14,6.4.1.2,6.4.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003386 327.0
HKD2_k127_5236811_2 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007327 299.0
HKD2_k127_5236811_3 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009368 278.0
HKD2_k127_5236811_4 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000005367 237.0
HKD2_k127_5249448_0 Belongs to the malate synthase family K01638 - 2.3.3.9 1e-230 725.0
HKD2_k127_5249448_1 KR domain - - - 0.000000000000000000000000000000000000000000000000000000002808 226.0
HKD2_k127_5269128_0 Acetyl-coenzyme A synthetase N-terminus K01895 - 6.2.1.1 1.106e-244 771.0
HKD2_k127_5269128_1 acyl-CoA dehydrogenase K00248 - 1.3.8.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 362.0
HKD2_k127_5269128_3 PFAM thioesterase superfamily K07107 - - 0.00000000000000000004191 96.0
HKD2_k127_5269128_4 Protein of unknown function (DUF983) - - - 0.0000000000000000001766 98.0
HKD2_k127_5269128_5 Cupredoxin-like domain - - - 0.0000000797 65.0
HKD2_k127_5269128_6 integral membrane protein - - - 0.000002082 56.0
HKD2_k127_5269128_7 including yeast histone deacetylase and acetoin utilization protein K04768 - - 0.0001764 46.0
HKD2_k127_5330716_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001716 488.0
HKD2_k127_5330716_1 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) K03110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009034 287.0
HKD2_k127_5330716_10 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000006579 54.0
HKD2_k127_5330716_2 Belongs to the RNA methyltransferase TrmD family K00554 GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005075 285.0
HKD2_k127_5330716_3 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000003237 228.0
HKD2_k127_5330716_4 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000002964 147.0
HKD2_k127_5330716_5 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000002209 151.0
HKD2_k127_5330716_6 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000000001765 109.0
HKD2_k127_5330716_7 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 GO:0008150,GO:0040007 - 0.00000000000000000005347 96.0
HKD2_k127_5330716_8 phosphotransferase activity, carboxyl group as acceptor K03830,K05715 - - 0.00000000000000093 84.0
HKD2_k127_5330716_9 Belongs to the UPF0109 family K06960 - - 0.000000000000008136 88.0
HKD2_k127_5434415_0 Aminotransferase class-III K15372 - 2.6.1.55 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 473.0
HKD2_k127_5434415_1 Belongs to the aldehyde dehydrogenase family K22187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004979 267.0
HKD2_k127_5434415_2 COGs COG2141 Coenzyme F420-dependent N5 N10-methylene tetrahydromethanopterin reductase - - - 0.00000000000000000000000000000000000000000000000001586 192.0
HKD2_k127_5434415_3 Putative stress-induced transcription regulator - - - 0.00000000000000000000000000000000000004044 150.0
HKD2_k127_5434415_4 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000003382 61.0
HKD2_k127_5436499_0 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 4.088e-199 652.0
HKD2_k127_5436499_1 ATP dependent DNA ligase C terminal region K10747 GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.1,6.5.1.6,6.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009907 468.0
HKD2_k127_5436499_10 PFAM Haloacid dehalogenase domain protein hydrolase - - - 0.0000000000000000000000000000000000002992 156.0
HKD2_k127_5436499_11 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family K12527 - 1.97.1.9 0.0008372 50.0
HKD2_k127_5436499_2 Domain of unknown function (DUF2088) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002776 372.0
HKD2_k127_5436499_3 Dehydrogenase K00001,K13954 - 1.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001021 298.0
HKD2_k127_5436499_4 histidine kinase, dimerisation and phosphoacceptor region - - - 0.000000000000000000000000000000000000000000000000000000007132 213.0
HKD2_k127_5436499_5 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000000000000000000000000135 193.0
HKD2_k127_5436499_6 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000006625 198.0
HKD2_k127_5436499_7 HD domain K07814 - - 0.0000000000000000000000000000000000000000000005828 183.0
HKD2_k127_5436499_8 Nitroreductase family - - - 0.00000000000000000000000000000000000000001454 159.0
HKD2_k127_5436499_9 His Kinase A (phosphoacceptor) domain K07636 - 2.7.13.3 0.0000000000000000000000000000000000000001888 173.0
HKD2_k127_5441906_0 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003071 264.0
HKD2_k127_5441906_1 phosphorelay signal transduction system K07667 - - 0.00000000000000000000000000000000000000000000000000000000002934 216.0
HKD2_k127_5441906_10 - - - - 0.00001345 52.0
HKD2_k127_5441906_11 - - - - 0.00011 54.0
HKD2_k127_5441906_2 Aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 0.000000000000000000000000000000000000000000000000000000001013 205.0
HKD2_k127_5441906_3 Prephenate dehydratase K04518,K14170 - 4.2.1.51,5.4.99.5 0.00000000000000000000000000000000000000000000000000000000118 216.0
HKD2_k127_5441906_4 ATPase activity K01990 - - 0.0000000000000000000000000000000000000000000005256 178.0
HKD2_k127_5441906_5 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000106 186.0
HKD2_k127_5441906_6 Histidine kinase K07646 - 2.7.13.3 0.000000000000000000000000000000000000008576 163.0
HKD2_k127_5441906_7 Cys/Met metabolism PLP-dependent enzyme K11325 - - 0.000000000000000000000000000000000003276 154.0
HKD2_k127_5441906_8 anaphase-promoting complex binding K07004 - - 0.000000000000000001922 102.0
HKD2_k127_5441906_9 transmembrane signaling receptor activity - - - 0.00000000006865 72.0
HKD2_k127_5469848_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 8.314e-259 811.0
HKD2_k127_5469848_1 Catalase domain protein K03781 - 1.11.1.6 4.297e-220 692.0
HKD2_k127_5469848_2 Involved in the biosynthesis of porphyrin-containing compound - GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - 0.000000000000000000000000000000000000000000000000000000000000000004974 242.0
HKD2_k127_5469848_3 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.00000000000000000000000000000000000000001617 165.0
HKD2_k127_5469848_5 TRANSCRIPTIONal - - - 0.00000000000000000000002572 111.0
HKD2_k127_5469848_6 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K10697 - - 0.000000000000000000002635 105.0
HKD2_k127_5521509_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system - - - 7.147e-307 954.0
HKD2_k127_5521509_1 Amino acid permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 604.0
HKD2_k127_5521509_2 Osmosensitive K+ channel His kinase sensor domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 391.0
HKD2_k127_5521509_3 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000003383 204.0
HKD2_k127_5521509_4 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex - - - 0.0000000000000000000000000000000000000000000000000007953 197.0
HKD2_k127_5521509_5 PFAM TrkA-N domain protein K03499 - - 0.000000000000000000000000000000000000000000000000008141 187.0
HKD2_k127_5521509_6 TrkA-N domain K03499,K10716 - - 0.000000000000000000000000000000000001225 146.0
HKD2_k127_5521509_7 Universal stress protein family - - - 0.0000000000000000000000008829 110.0
HKD2_k127_5535362_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009546 496.0
HKD2_k127_5535362_1 EamA-like transporter family - - - 0.00000000000000000000000000000000000005006 153.0
HKD2_k127_5535362_2 MarR family transcriptional regulator - - - 0.00000000003291 71.0
HKD2_k127_5535362_3 PRC-barrel domain - - - 0.0002958 51.0
HKD2_k127_5545959_0 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 610.0
HKD2_k127_5545959_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006233 321.0
HKD2_k127_5545959_2 Radical SAM domain protein - - - 0.0000000000000000000000000000000000000000002474 171.0
HKD2_k127_5545959_3 Lysin motif - - - 0.000000000000000000000000000000000005223 153.0
HKD2_k127_5545959_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.000000000000000000000000000000002062 132.0
HKD2_k127_5545959_5 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000009668 116.0
HKD2_k127_5545959_6 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L K00340 GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000003688 107.0
HKD2_k127_5545959_7 Belongs to the complex I subunit 6 family K05578 - 1.6.5.3 0.00000000000000000001803 97.0
HKD2_k127_5573677_0 Glycosyl hydrolase family 65 central catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004903 580.0
HKD2_k127_5573677_1 Cys/Met metabolism PLP-dependent enzyme K01739,K01758,K01760,K01761 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 490.0
HKD2_k127_5573677_10 protein secretion K03116 - - 0.00000000009533 64.0
HKD2_k127_5573677_11 TadE-like protein - - - 0.000003743 58.0
HKD2_k127_5573677_12 Putative Flp pilus-assembly TadE/G-like - - - 0.00001435 58.0
HKD2_k127_5573677_13 Pilus assembly protein CpaB K02279 - - 0.00001964 57.0
HKD2_k127_5573677_14 bacterial-type flagellum organization - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - 0.00003581 56.0
HKD2_k127_5573677_2 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 335.0
HKD2_k127_5573677_3 COG4962 Flp pilus assembly protein, ATPase CpaF K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002077 256.0
HKD2_k127_5573677_4 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000003506 226.0
HKD2_k127_5573677_5 Cysteine synthase K01697,K01738,K12339 - 2.5.1.47,4.2.1.22 0.000000000000000000000000000000000000009099 150.0
HKD2_k127_5573677_6 PFAM cytochrome c biogenesis protein, transmembrane region K06196 - - 0.00000000000000000000000000000000000001661 152.0
HKD2_k127_5573677_7 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.00000000000000000000000002238 122.0
HKD2_k127_5573677_8 phosphorelay signal transduction system - - - 0.000000000000002719 80.0
HKD2_k127_5573677_9 PFAM amino acid-binding ACT domain protein - - - 0.00000000004978 68.0
HKD2_k127_5586160_0 multicopper oxidase type 3 K00368 - 1.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008536 366.0
HKD2_k127_5586160_1 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007066 264.0
HKD2_k127_5586160_2 Uncharacterized conserved protein (DUF2249) - - - 0.00000000000000000000000000000002623 136.0
HKD2_k127_5586160_3 Peptidase family M23 K21471 - - 0.00000000000000000003145 105.0
HKD2_k127_5586160_4 hydrolase, family 3 K01207 - 3.2.1.52 0.000000000000000001357 95.0
HKD2_k127_5586160_5 lipolytic protein G-D-S-L family - - - 0.0000000000000003508 89.0
HKD2_k127_5631006_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001098 335.0
HKD2_k127_5631006_1 Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system K02041 - 3.6.3.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006458 299.0
HKD2_k127_5631006_2 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591,K13421 GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.10,4.1.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000002453 252.0
HKD2_k127_5631006_3 ABC transporter (Permease) K02042 - - 0.0000000000000000000000000000000000000000000008115 186.0
HKD2_k127_5631006_4 ABC-type phosphate phosphonate transport system periplasmic component K02044 - - 0.000000000000000000000000000000000000000002232 168.0
HKD2_k127_5631006_5 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.0000000000001119 76.0
HKD2_k127_5631006_6 WD40-like Beta Propeller Repeat - - - 0.000000000208 68.0
HKD2_k127_5631006_7 protein secretion K03116,K03117 GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - 0.00000002436 61.0
HKD2_k127_566760_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 1.693e-293 909.0
HKD2_k127_566760_1 3-isopropylmalate dehydrogenase activity K00030 - 1.1.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 318.0
HKD2_k127_566760_2 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003856 322.0
HKD2_k127_566760_3 Sigma-54 interaction domain K03696 - - 0.0000000000000000000000000000000000000000000000004265 184.0
HKD2_k127_566760_4 Low molecular weight phosphotyrosine protein phosphatase K03741 - 1.20.4.1 0.0000000000000000000000000000000000000004272 152.0
HKD2_k127_566760_5 LysR substrate binding domain K21703 - - 0.0000000000000000000000000000001727 136.0
HKD2_k127_566760_6 Helix-turn-helix domain - - - 0.00000000000000000000002182 108.0
HKD2_k127_566760_7 Uncharacterised MFS-type transporter YbfB - - - 0.0000000000464 75.0
HKD2_k127_566760_8 - - - - 0.0000001655 64.0
HKD2_k127_567873_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K01848 - 5.4.99.2 1.021e-210 670.0
HKD2_k127_567873_1 PFAM Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006745 379.0
HKD2_k127_567873_2 periplasmic protein kinase ArgK and related GTPases of G3E family K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 323.0
HKD2_k127_567873_3 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000005574 297.0
HKD2_k127_567873_4 TIGRFAM methylmalonyl-CoA mutase C-terminal domain K01849 - 5.4.99.2 0.0000000000000000000000000000000000000000000002751 190.0
HKD2_k127_567873_5 Protein of unknown function (DUF1706) - - - 0.00002444 57.0
HKD2_k127_5686067_0 Catalyzes the transfer of a methyl group to L- homocysteine resulting in methionine formation. The physiological methyl donor is K00549 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0042085,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050667,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002386 390.0
HKD2_k127_5686067_1 redox protein regulator of disulfide bond formation - - - 0.00000000000000000000000000000000000000000000008447 174.0
HKD2_k127_5686067_2 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000005669 106.0
HKD2_k127_5686067_3 Belongs to the UPF0102 family K07460 - - 0.000000000005245 74.0
HKD2_k127_572308_0 PFAM amidohydrolase K01464,K01465 - 3.5.2.2,3.5.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 577.0
HKD2_k127_572308_1 L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000239 547.0
HKD2_k127_572308_10 Amidohydrolase family K12960 - 3.5.4.28,3.5.4.31 0.00000000000000000000000000000000000000000000000000000000008418 223.0
HKD2_k127_572308_11 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.000000000000000000000000000000000000000000000000000005193 214.0
HKD2_k127_572308_12 Bacterial extracellular solute-binding proteins, family 5 Middle K02035,K13889 - - 0.000000000000000000000000000000000000000000000000002318 202.0
HKD2_k127_572308_13 helix_turn_helix isocitrate lyase regulation - - - 0.00000000000000000000000000000000000000000002364 184.0
HKD2_k127_572308_14 Oxidoreductase family, C-terminal alpha/beta domain - - - 0.000000000000000000000007846 113.0
HKD2_k127_572308_15 - - - - 0.0000000000000000000001276 100.0
HKD2_k127_572308_16 Uncharacterised MFS-type transporter YbfB - - - 0.0000000000000000001041 104.0
HKD2_k127_572308_17 - - - - 0.0000000265 65.0
HKD2_k127_572308_2 MmgE/PrpD family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007406 478.0
HKD2_k127_572308_3 FAD binding domain K00244 - 1.3.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 406.0
HKD2_k127_572308_4 Fungal trichothecene efflux pump (TRI12) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002856 344.0
HKD2_k127_572308_5 cyclase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008476 306.0
HKD2_k127_572308_6 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033,K15581 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 288.0
HKD2_k127_572308_7 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007283 285.0
HKD2_k127_572308_8 PFAM amidohydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000004029 235.0
HKD2_k127_572308_9 PFAM amidohydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000002246 230.0
HKD2_k127_5749607_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 454.0
HKD2_k127_5749607_1 PFAM ABC transporter related K10112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001136 454.0
HKD2_k127_5749607_2 PFAM ROK family protein K00845 - 2.7.1.2 0.0000000000000000000000000000000000000000000008349 178.0
HKD2_k127_5749607_3 Phosphoglycerate kinase K00927 GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3 0.0000000001804 61.0
HKD2_k127_5749607_4 Domain of unknown function (DUF4388) - - - 0.00001985 58.0
HKD2_k127_5779100_0 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000002415 241.0
HKD2_k127_5779100_1 Double-stranded RNA binding motif K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.000000000000000000000000000000000000000000002226 173.0
HKD2_k127_5779100_2 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - 0.00000000000000000000000001004 111.0
HKD2_k127_5779100_3 Sigma-70, region 4 - - - 0.000000000000000003327 90.0
HKD2_k127_583227_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002387 605.0
HKD2_k127_583227_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 312.0
HKD2_k127_583227_2 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001737 274.0
HKD2_k127_5836560_0 DEAD DEAH box K03724 - - 0.0 1638.0
HKD2_k127_5836560_1 Winged helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003909 332.0
HKD2_k127_5836560_2 Belongs to the FPG family K05522 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000009792 214.0
HKD2_k127_5836560_3 ABC-type nitrate sulfonate bicarbonate transport system ATPase component K02049 - - 0.0000000000000000000000000000000000000000000000000000000002442 211.0
HKD2_k127_5836560_4 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000004285 182.0
HKD2_k127_5836560_5 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000001295 185.0
HKD2_k127_5836560_6 helix_turn_helix, arabinose operon control protein - - - 0.000000000000000000000000000000000000000000043 169.0
HKD2_k127_5836560_7 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity - - - 0.00000000000000000008567 96.0
HKD2_k127_5836560_8 Domain of unknown function (DU1801) - - - 0.000001784 56.0
HKD2_k127_5937497_0 Permease family K06901 GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015208,GO:0015851,GO:0015854,GO:0016020,GO:0022857,GO:0035344,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098657,GO:0098710,GO:0098739,GO:1903716,GO:1904823 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 362.0
HKD2_k127_5937497_1 Putative pyruvate format-lyase activating enzyme (DUF1786) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000754 347.0
HKD2_k127_5937497_10 PFAM binding-protein-dependent transport systems inner membrane component K02033 - - 0.00000000004069 75.0
HKD2_k127_5937497_2 Amidase K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006633 299.0
HKD2_k127_5937497_3 Protein of unknown function (DUF1015) - - - 0.0000000000000000000000000000000000000000000000000000000003949 222.0
HKD2_k127_5937497_4 - - - - 0.000000000000000000000000000000000000000000000000006544 187.0
HKD2_k127_5937497_5 RNase_H superfamily K07502 - - 0.00000000000000000000000000000000000000000000001498 184.0
HKD2_k127_5937497_6 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.000000000000000000000000000000003602 139.0
HKD2_k127_5937497_7 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000008083 130.0
HKD2_k127_5937497_8 dehydrogenase complex catalyzes the overall conversion of - - - 0.000000000000000000000001474 109.0
HKD2_k127_5937497_9 Binding-protein-dependent transport system inner membrane component K02034 - - 0.00000000000000000001571 108.0
HKD2_k127_603162_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 7.255e-247 781.0
HKD2_k127_603162_1 CobQ CobB MinD ParA nucleotide binding domain K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001147 287.0
HKD2_k127_603162_2 ParB-like nuclease domain K03497 - - 0.00000000000000000000000000000000000000000000000000000000000000000001622 243.0
HKD2_k127_603162_3 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0000000000000000000000000000000000000000000000000000000000000002372 233.0
HKD2_k127_603162_4 Thioesterase superfamily - - - 0.0000000000000000000000000000228 123.0
HKD2_k127_636590_0 COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K04108 - 1.3.7.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008682 385.0
HKD2_k127_636590_1 2Fe-2S -binding domain protein K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000007691 229.0
HKD2_k127_636590_2 response regulator - - - 0.00000000000000001447 95.0
HKD2_k127_636590_3 Histidine kinase - - - 0.0000000000000026 88.0
HKD2_k127_636590_4 helix_turn_helix isocitrate lyase regulation - - - 0.00000000000001796 84.0
HKD2_k127_6399817_0 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000604 580.0
HKD2_k127_6399817_1 Domain of unknown function (DUF4118) K13924 - 2.1.1.80,3.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000251 404.0
HKD2_k127_6399817_2 Peptidase, M20 - - - 0.0000000000000000000000000000000000000000000000000000004406 206.0
HKD2_k127_6411901_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000937 444.0
HKD2_k127_6411901_1 Oligopeptide/dipeptide transporter, C-terminal region K02031 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007545 406.0
HKD2_k127_6411901_10 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000209 104.0
HKD2_k127_6411901_11 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin K01633 - 1.13.11.81,4.1.2.25,5.1.99.8 0.00000000001913 69.0
HKD2_k127_6411901_12 abc transporter, permease K02050 - - 0.00000000008397 64.0
HKD2_k127_6411901_2 Belongs to the ABC transporter superfamily K02032 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007708 392.0
HKD2_k127_6411901_3 peptidase dimerisation domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007796 367.0
HKD2_k127_6411901_4 nitrogen compound transport K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000249 361.0
HKD2_k127_6411901_5 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034,K15582 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001173 292.0
HKD2_k127_6411901_6 PFAM NMT1 THI5 like domain protein K02051,K15598 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001301 295.0
HKD2_k127_6411901_7 Mur ligase family, glutamate ligase domain K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000004969 261.0
HKD2_k127_6411901_8 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000000001122 214.0
HKD2_k127_6411901_9 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000003256 165.0
HKD2_k127_6435381_0 Peptidase S9, prolyl oligopeptidase active site domain protein K01322 - 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008277 392.0
HKD2_k127_6435381_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002243 293.0
HKD2_k127_6435381_2 PFAM ABC-2 type transporter K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008719 283.0
HKD2_k127_6435381_3 'Phosphotransferase - - - 0.0000000000000000000000000000000000000000000000000000000008825 217.0
HKD2_k127_6435381_4 Peptidase, M23 - - - 0.0000000000000000000000000000000564 134.0
HKD2_k127_6435381_5 methylamine metabolic process K15977 - - 0.00000000000000000000000000000008247 131.0
HKD2_k127_6435381_7 Phosphotransferase enzyme family - - - 0.0003457 48.0
HKD2_k127_6489920_0 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002978 306.0
HKD2_k127_6489920_1 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine - - - 0.0000000000000000000000000000000000000000000000000008305 207.0
HKD2_k127_6489920_2 transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000000001586 187.0
HKD2_k127_6489920_3 Endonuclease/Exonuclease/phosphatase family - - - 0.00000000000000000000000000000000000000003858 172.0
HKD2_k127_6489920_4 Thioredoxin-like domain K03671 - - 0.000000000000000000000000000000000000165 146.0
HKD2_k127_6489920_5 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000002539 108.0
HKD2_k127_6489920_6 E1-E2 ATPase K01533,K17686 - 3.6.3.4,3.6.3.54 0.0008026 49.0
HKD2_k127_6506576_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 6.2.1.1 3.579e-318 986.0
HKD2_k127_6506576_1 Sugar (and other) transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009302 491.0
HKD2_k127_6506576_2 May be involved in recombinational repair of damaged DNA K03631 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 329.0
HKD2_k127_6506576_3 ATPase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000008101 296.0
HKD2_k127_6506576_4 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 - 1.8.1.4 0.0000000000000000000000000000000000000000000000000000000001657 212.0
HKD2_k127_6506576_5 regulation of translation K03530 - - 0.0000000000000000000000000000003863 124.0
HKD2_k127_6506576_6 transmembrane transport K01992 - - 0.000000000000000000000000000008495 135.0
HKD2_k127_6506576_7 Acetyltransferase (GNAT) family - - - 0.0000000000000000000001454 109.0
HKD2_k127_6506576_8 CsbD-like - - - 0.0000000002039 64.0
HKD2_k127_6506576_9 - - - - 0.00000001549 61.0
HKD2_k127_6544322_0 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008071 471.0
HKD2_k127_6544322_1 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0030312,GO:0032259,GO:0034641,GO:0035999,GO:0036211,GO:0040007,GO:0042084,GO:0042085,GO:0042558,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0050667,GO:0051186,GO:0071704,GO:0071944,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009541 371.0
HKD2_k127_6544322_2 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.000000000000000000000000000000000008266 140.0
HKD2_k127_6544322_3 Platelet-activating factor acetylhydrolase, isoform II - - - 0.000000000001159 79.0
HKD2_k127_6559851_0 Ferric reductase like transmembrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004074 335.0
HKD2_k127_6559851_1 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000002987 219.0
HKD2_k127_6559851_2 Base excision DNA repair protein K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000001586 191.0
HKD2_k127_6559851_3 Rhodanese Homology Domain - - - 0.000000000000000000000000000000000000000000000009622 182.0
HKD2_k127_6559851_4 RNA polymerase sigma factor K03088 GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - 0.00000000000000000000000000000000000729 139.0
HKD2_k127_6559851_5 FMN_bind - - - 0.000000000000000000004234 99.0
HKD2_k127_6583762_0 Endoribonuclease that initiates mRNA decay K18682 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009917 573.0
HKD2_k127_6583762_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0050896,GO:0051704,GO:0051716,GO:0071496 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001692 466.0
HKD2_k127_6583762_10 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.000000000000000001563 89.0
HKD2_k127_6583762_11 Protein of unknown function (DUF2905) - - - 0.00000000000104 70.0
HKD2_k127_6583762_12 Pfam:DUF59 - - - 0.00000000000525 70.0
HKD2_k127_6583762_2 TIGRFAM metallophosphoesterase, MG_246 BB_0505 family K09769 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002003 275.0
HKD2_k127_6583762_3 DNA polymerase alpha chain like domain K07053 - 3.1.3.97 0.000000000000000000000000000000000000000000000000000000000000000000003912 254.0
HKD2_k127_6583762_4 Peptidyl-prolyl cis-trans K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000001748 160.0
HKD2_k127_6583762_5 aminoglycoside hydroxyurea antibiotic resistance kinase K04343 - 2.7.1.72 0.00000000000000000000000000000004945 136.0
HKD2_k127_6583762_6 PFAM Cobalamin adenosyltransferase K00798 - 2.5.1.17 0.0000000000000000000000000000006864 132.0
HKD2_k127_6583762_7 Major Facilitator Superfamily - - - 0.0000000000000000000000007683 119.0
HKD2_k127_6583762_8 Modulates RecA activity K03565 - - 0.00000000000000000000001047 110.0
HKD2_k127_6583762_9 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.000000000000000000005169 93.0
HKD2_k127_6599216_0 Belongs to the UPF0271 (lamB) family K07160 - - 0.000000000000000000000000000000000000000000000000000000000000000004115 238.0
HKD2_k127_6599216_1 Allophanate hydrolase subunit 2 - - - 0.00000000000000000000000000000000000000000000000009987 188.0
HKD2_k127_6599216_2 Allophanate hydrolase subunit 1 - - - 0.0000000000000000000000000000000000000000000003296 177.0
HKD2_k127_6599216_3 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 0.00000000000000000001019 100.0
HKD2_k127_6599216_4 Involved in the tonB-independent uptake of proteins K03641 - - 0.0002346 53.0
HKD2_k127_6686069_0 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005442 285.0
HKD2_k127_6686069_1 Belongs to the binding-protein-dependent transport system permease family - - - 0.000000000000000000000000000000000000000000000000000000000000000000006871 244.0
HKD2_k127_6686069_2 Branched-chain amino acid ATP-binding cassette transporter - - - 0.00000000000000000000000000000000000000000000000000000000000003989 239.0
HKD2_k127_6686069_3 COG0410 ABC-type branched-chain amino acid transport systems, ATPase component K11963 - - 0.00000000000000000000000000000000000000000000000000000000003901 218.0
HKD2_k127_6686069_4 Branched-chain amino acid transport system / permease component - - - 0.00000000000000000000000000000000000000000000000000000000004491 223.0
HKD2_k127_6686069_5 Thiolase, C-terminal domain - - - 0.00000000000000000000000000000000000000000007324 162.0
HKD2_k127_669665_0 adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005862 464.0
HKD2_k127_669665_1 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 335.0
HKD2_k127_669665_2 Imidazolonepropionase and related amidohydrolases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000005106 276.0
HKD2_k127_669665_3 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000000000000000000000000000000000003005 182.0
HKD2_k127_669665_4 phosphorelay signal transduction system - - - 0.00000000000000000000000000000000000000000001721 169.0
HKD2_k127_669665_5 ATP-binding region, ATPase domain protein - - - 0.000000000000000000000000000000000000000001065 175.0
HKD2_k127_669665_6 ABC-2 family transporter protein - - - 0.00000000000000000000000000000000003443 149.0
HKD2_k127_6725084_0 Sugar (and other) transporter K08369 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005798 482.0
HKD2_k127_6725084_1 Belongs to the aspartate-semialdehyde dehydrogenase family K00133 - 1.2.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 400.0
HKD2_k127_6725084_2 ACT domain K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004597 395.0
HKD2_k127_6725084_3 Hpt domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006519 360.0
HKD2_k127_6725084_4 Homoserine dehydrogenase K00003 - 1.1.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000008698 252.0
HKD2_k127_6725084_5 ABC transporter substrate binding protein K01989 - - 0.0000000000000000000000000000000000000000000364 173.0
HKD2_k127_6725084_6 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.00000000000000000000000000000000000000003716 168.0
HKD2_k127_6725084_7 Transcriptional regulator - - - 0.00000000000000000000000000000000000000005036 167.0
HKD2_k127_6725084_8 ABC transporter substrate binding protein K01989 - - 0.00000000000000000000000000000000911 141.0
HKD2_k127_6725084_9 TIGRFAM competence damage-inducible protein CinA K03742,K03743 - 3.5.1.42 0.0009163 43.0
HKD2_k127_6748644_0 Belongs to the aldehyde dehydrogenase family K22187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001435 436.0
HKD2_k127_6748644_1 helix_turn_helix, Arsenical Resistance Operon Repressor - - - 0.00000000000000000000000000000000000000000002167 164.0
HKD2_k127_6748644_2 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.00000000000000000000000002006 117.0
HKD2_k127_6748644_3 Protein of unknown function (DUF3465) - - - 0.0000000000000000000001899 104.0
HKD2_k127_6748644_4 Glyoxalase-like domain - - - 0.00000000000000001918 85.0
HKD2_k127_675557_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001688 452.0
HKD2_k127_675557_1 Short-chain dehydrogenase reductase SDR K01784,K12454 - 5.1.3.10,5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000001029 229.0
HKD2_k127_675557_2 Probable zinc-ribbon domain - - - 0.000000000000000000000000000003804 121.0
HKD2_k127_675557_3 DUF218 domain - - - 0.00000000000000004721 90.0
HKD2_k127_6771565_0 PFAM regulatory protein LuxR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001089 467.0
HKD2_k127_6771565_1 Belongs to the class-I aminoacyl-tRNA synthetase family K15526 - 6.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001071 340.0
HKD2_k127_6771565_2 Sugar (and other) transporter K08151 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004698 278.0
HKD2_k127_6771565_3 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000006538 172.0
HKD2_k127_6771565_4 succinylglutamate desuccinylase aspartoacylase K06987 - - 0.0000000000000000000000000000000000000005861 164.0
HKD2_k127_6771565_5 Mov34 MPN PAD-1 family K21140 - 3.13.1.6 0.00000000000000000000000000000554 125.0
HKD2_k127_6771565_6 aminopeptidase activity - - - 0.000000000000000000000000000282 128.0
HKD2_k127_6771565_7 Mo-molybdopterin cofactor metabolic process K03636,K21147 - 2.7.7.80,2.8.1.11 0.00005527 51.0
HKD2_k127_6777509_0 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003889 314.0
HKD2_k127_6777509_1 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.00000000000000000000000000000000000000000000000000000000000000000704 231.0
HKD2_k127_6777509_2 FtsJ-like methyltransferase K06442 - 2.1.1.226,2.1.1.227 0.00000000000000000000000000000000000000000000000000000000000000002867 233.0
HKD2_k127_6777509_3 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.000000000000000000000000000000000000000000002697 169.0
HKD2_k127_6777509_4 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000009322 130.0
HKD2_k127_6777509_5 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000004252 119.0
HKD2_k127_6777509_6 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000976 57.0
HKD2_k127_6835961_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000003625 273.0
HKD2_k127_6835961_1 Domain of unknown function (DUF4395) - - - 0.00000000000008906 80.0
HKD2_k127_6835961_2 Domain of unknown function (DUF1992) - - - 0.00001121 57.0
HKD2_k127_6861493_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K09458 - 2.3.1.179 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 502.0
HKD2_k127_6861493_1 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000871 429.0
HKD2_k127_6861493_2 reductase K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005453 289.0
HKD2_k127_6861493_3 Responsible for synthesis of pseudouridine from uracil K06180 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 0.00000000000000000000000000000000000000000000000000000000000000003228 243.0
HKD2_k127_6861493_4 Acyl transferase domain K00645 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000001256 205.0
HKD2_k127_6861493_5 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.000000000000000000000000000000000000009012 153.0
HKD2_k127_6861493_6 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000003563 110.0
HKD2_k127_6883914_0 PFAM Type II IV secretion system protein K02283 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 361.0
HKD2_k127_6883914_1 PFAM CobB CobQ domain protein glutamine amidotransferase K07009 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004486 250.0
HKD2_k127_6883914_2 Major facilitator superfamily - - - 0.000000000000000000000000000000000000000632 154.0
HKD2_k127_6883914_3 TfoX N-terminal domain - - - 0.00000001408 61.0
HKD2_k127_6883914_4 TadE-like protein - - - 0.0000004035 58.0
HKD2_k127_6883914_5 Chromosome partitioning K03496 - - 0.000001075 61.0
HKD2_k127_6883914_6 type II secretion K12511 - - 0.000004171 59.0
HKD2_k127_6883914_7 PFAM Mur ligase, middle domain protein - - - 0.00003522 46.0
HKD2_k127_6887559_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639,K00652 - 2.3.1.29,2.3.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000456 505.0
HKD2_k127_6887559_1 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002583 484.0
HKD2_k127_6887559_10 AraC-like ligand binding domain - - - 0.000000000000006998 81.0
HKD2_k127_6887559_11 PFAM TadE family protein - - - 0.00000000427 65.0
HKD2_k127_6887559_12 - - - - 0.000000004827 65.0
HKD2_k127_6887559_2 Belongs to the glycosyl hydrolase 5 (cellulase A) family K01190 - 3.2.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009804 346.0
HKD2_k127_6887559_3 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 310.0
HKD2_k127_6887559_4 PFAM peptidase M48 Ste24p K03799 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005916 305.0
HKD2_k127_6887559_5 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000000000000000000000000000000000000000000000000000001108 205.0
HKD2_k127_6887559_6 ABC-2 family transporter protein - - - 0.00000000000000000000000000000000000000000000000005264 188.0
HKD2_k127_6887559_7 RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000003132 121.0
HKD2_k127_6887559_8 PFAM TadE family protein - - - 0.00000000000000000000000001426 126.0
HKD2_k127_6887559_9 Ndr family - - - 0.00000000000000000000000004148 114.0
HKD2_k127_69972_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 3.759e-236 751.0
HKD2_k127_69972_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 1.755e-201 647.0
HKD2_k127_69972_10 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885,K15977 - 1.6.99.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004216 302.0
HKD2_k127_69972_11 transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003299 280.0
HKD2_k127_69972_12 Riboflavin kinase K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000033 254.0
HKD2_k127_69972_13 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000002709 205.0
HKD2_k127_69972_14 PFAM phosphoesterase, RecJ domain protein K06881 - 3.1.13.3,3.1.3.7 0.000000000000000000000000000000000000000000000000001824 197.0
HKD2_k127_69972_16 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.0000000000000000000000000000000000000000000003221 182.0
HKD2_k127_69972_17 RibD C-terminal domain K00287 - 1.5.1.3 0.000000000000000000000000000000000000000000001704 186.0
HKD2_k127_69972_18 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000005243 171.0
HKD2_k127_69972_19 Phosphotransferase enzyme family K18817 - 2.7.1.163 0.0000000000000000000000000000000000001093 153.0
HKD2_k127_69972_2 elongation factor G K02355 - - 1.097e-195 631.0
HKD2_k127_69972_20 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000002292 137.0
HKD2_k127_69972_21 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000002476 139.0
HKD2_k127_69972_22 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.0000000000000000000000006147 106.0
HKD2_k127_69972_23 - - - - 0.000000000000000000000002265 110.0
HKD2_k127_69972_24 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.00000000000000000002887 103.0
HKD2_k127_69972_25 Protein of unknown function (DUF448) K07742 - - 0.00000000000000002978 91.0
HKD2_k127_69972_26 NUDIX domain K03574 - 3.6.1.55 0.0000000000000003757 84.0
HKD2_k127_69972_27 COG0457 FOG TPR repeat - - - 0.0000003151 63.0
HKD2_k127_69972_28 Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides K03478 - 3.5.1.105 0.000001127 58.0
HKD2_k127_69972_3 PFAM Prolyl oligopeptidase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008073 621.0
HKD2_k127_69972_4 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001786 500.0
HKD2_k127_69972_5 PFAM glycosyl transferase, family 51 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004241 410.0
HKD2_k127_69972_6 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 391.0
HKD2_k127_69972_7 Binding-protein-dependent transport system inner membrane component K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 385.0
HKD2_k127_69972_8 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000132 373.0
HKD2_k127_69972_9 Participates in both transcription termination and antitermination K02600 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001606 364.0
HKD2_k127_7022754_0 Cytochrome C assembly protein K02198,K04016 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0018193,GO:0018198,GO:0018378,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004412 534.0
HKD2_k127_7022754_1 Cytochrome C assembly protein K02195 - - 0.00000000000000000000000000000000000000000000000000000000000000000513 234.0
HKD2_k127_7022754_10 FecR protein - - - 0.0001462 54.0
HKD2_k127_7022754_11 Cytochrome c-type biogenesis protein K02200 - - 0.000946 51.0
HKD2_k127_7022754_2 Redoxin K02199 - - 0.000000000000000000000000000000000001612 144.0
HKD2_k127_7022754_3 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000007121 137.0
HKD2_k127_7022754_4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system K02193 - 3.6.3.41 0.00000000000000000000000003176 115.0
HKD2_k127_7022754_5 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH K02197 - - 0.00000000000000000001532 98.0
HKD2_k127_7022754_6 subunit of a heme lyase K02200 - - 0.0000000000000000005105 97.0
HKD2_k127_7022754_7 ABC-type transport system involved in cytochrome c biogenesis permease component K02194 - - 0.00000000000000008443 91.0
HKD2_k127_7022754_9 Cytochrome c K05301 - 1.8.2.1 0.00000000178 66.0
HKD2_k127_7025352_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 439.0
HKD2_k127_7025352_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000008588 177.0
HKD2_k127_7025352_2 DsrE/DsrF-like family - - - 0.0000000000000000000000000000000000000001387 160.0
HKD2_k127_7025352_3 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000203 108.0
HKD2_k127_7025352_4 Belongs to the sulfur carrier protein TusA family K04085 - - 0.000000000000000000222 92.0
HKD2_k127_7025352_5 sulfur carrier activity - - - 0.00000000000000001758 87.0
HKD2_k127_7092934_0 Cation transporter/ATPase, N-terminus K01537 - 3.6.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008667 558.0
HKD2_k127_7092934_1 Putative FMN-binding domain K07734 - - 0.000000000000000000000000000000000000000000000000000000000000000003133 233.0
HKD2_k127_7092934_2 homoserine transmembrane transporter activity - - - 0.00000000000000000000000000000000000000000002973 169.0
HKD2_k127_7092934_3 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.000000000000000000000000000000000157 135.0
HKD2_k127_7092934_4 Probable zinc-ribbon domain - - - 0.0000000000000000000000000000000007484 144.0
HKD2_k127_7200646_0 Subtilase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001268 289.0
HKD2_k127_7200646_1 Serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000002168 230.0
HKD2_k127_7200646_2 - - - - 0.000000000000278 82.0
HKD2_k127_7200646_3 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 - 2.4.1.21 0.00000000000108 71.0
HKD2_k127_7223751_0 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides K00088 GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004258 389.0
HKD2_k127_7223751_1 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 0.00000000000000000000000000000000000000000000000000000000000000000006261 237.0
HKD2_k127_7223751_2 signal peptidase K13280 - 3.4.21.89 0.000000000005742 75.0
HKD2_k127_7223751_3 Camelysin metallo-endopeptidase - - - 0.00000698 50.0
HKD2_k127_7223751_4 - - - - 0.000009392 54.0
HKD2_k127_7223751_5 Concanavalin A-like lectin/glucanases superfamily - - - 0.0008932 52.0
HKD2_k127_7272180_0 Cell division protein FtsA K03569 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 437.0
HKD2_k127_7272180_1 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001517 279.0
HKD2_k127_7272180_10 Glycosyltransferase family 87 - - - 0.000001762 60.0
HKD2_k127_7272180_11 Iron permease FTR1 family K07243 - - 0.000002841 50.0
HKD2_k127_7272180_2 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.0000000000000000000000000000000000000000000000000005336 205.0
HKD2_k127_7272180_3 Belongs to the glycosyltransferase 26 family K05946 - 2.4.1.187 0.000000000000000000000000000000000000000000000000007509 190.0
HKD2_k127_7272180_4 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000000000000005475 184.0
HKD2_k127_7272180_5 PHP-associated - - - 0.00000000000000000000000000000000000000000001157 172.0
HKD2_k127_7272180_6 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase K07777 - 2.7.13.3 0.000000000000000000000000000000000000000002352 168.0
HKD2_k127_7272180_7 oligosaccharyl transferase activity - - - 0.0000000000000000000000000000000000000005382 165.0
HKD2_k127_7272180_8 oligosaccharyl transferase activity - - - 0.0000000000000000000002028 112.0
HKD2_k127_73120_0 Flavin-binding monooxygenase-like K07222 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001135 432.0
HKD2_k127_73120_1 Belongs to the RimK family K05827,K05844,K14940,K18310 - 6.3.1.17,6.3.2.32,6.3.2.41,6.3.2.43 0.0000000000000000000000000000000000000000000002266 173.0
HKD2_k127_73120_2 Polysaccharide deacetylase - - - 0.00000000000000000000000000000000000006508 153.0
HKD2_k127_73120_3 lysine biosynthesis protein LysW K05826 - - 0.00000000000001356 75.0
HKD2_k127_7656794_0 ATP-grasp domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001591 355.0
HKD2_k127_7656794_1 transglycosylase - - - 0.0000000000000000000000000000000000000000000000000000000005439 212.0
HKD2_k127_7656794_2 Polyketide cyclase / dehydrase and lipid transport - - - 0.000000648 58.0
HKD2_k127_7685327_0 FAD dependent oxidoreductase K00109,K15736 - 1.1.99.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005843 472.0
HKD2_k127_7685327_1 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.000000000000000000000000000000000000000000000000000006394 205.0
HKD2_k127_7685327_2 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765,K02502 - 2.4.2.17 0.00000000000000000000000000000000000000000000000000001645 195.0
HKD2_k127_7685327_3 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.00000000000000000000000000000000000000001314 154.0
HKD2_k127_7685327_4 YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the K09780 - - 0.00000000000000000000000000000000836 130.0
HKD2_k127_7685327_5 arylformamidase activity - - - 0.00000000000000000000000000000006211 134.0
HKD2_k127_7685327_6 Chromate transporter K07240 - - 0.00000000000000006143 93.0
HKD2_k127_7685327_7 Chromate transport protein K07240 - - 0.0002332 50.0
HKD2_k127_7687057_0 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 590.0
HKD2_k127_7687057_1 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009701 323.0
HKD2_k127_7687057_2 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002029 305.0
HKD2_k127_7706264_0 Major facilitator Superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 361.0
HKD2_k127_7706264_1 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007993 331.0
HKD2_k127_7706264_2 beta-1,4-mannooligosaccharide phosphorylase K20885 - 2.4.1.339,2.4.1.340 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001698 299.0
HKD2_k127_7706264_3 PFAM beta-lactamase domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001576 294.0
HKD2_k127_7706264_4 VIT family - - - 0.00000000000000000000002949 111.0
HKD2_k127_7706264_5 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.00000000000001229 75.0
HKD2_k127_7744879_0 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 300.0
HKD2_k127_7744879_1 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain K07117 - - 0.0000000000000000000000000000004298 128.0
HKD2_k127_7744879_2 Secreted repeat of unknown function - - - 0.0000000000000000000000001577 111.0
HKD2_k127_7744879_3 - - - - 0.000000000208 68.0
HKD2_k127_7769238_0 Heterodisulfide reductase, subunit B K03389 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003143 610.0
HKD2_k127_7769238_1 PFAM Cysteine-rich domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 537.0
HKD2_k127_7769238_2 4fe-4S ferredoxin, iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001182 426.0
HKD2_k127_7769238_3 4Fe-4S dicluster domain K03390 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001295 361.0
HKD2_k127_7769238_4 - - - - 0.00000000000000000000000000000000000000000000000000008703 195.0
HKD2_k127_7769238_5 - K07092 - - 0.0000000000000000000000000000000000002425 142.0
HKD2_k127_77924_0 PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001285 433.0
HKD2_k127_77924_1 Mo-co oxidoreductase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006359 320.0
HKD2_k127_77924_2 COG1472 Beta-glucosidase-related glycosidases K01207 - 3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000002382 275.0
HKD2_k127_77924_3 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate K07106 - 4.2.1.126 0.000000000000000000000000000000000000000000000000000000000000000000000000008659 267.0
HKD2_k127_77924_4 Anhydro-N-acetylmuramic acid kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002952 251.0
HKD2_k127_77924_5 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000003744 195.0
HKD2_k127_77924_6 BadF/BadG/BcrA/BcrD ATPase family - - - 0.0000000000000000000000000000000000001284 158.0
HKD2_k127_77924_7 Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides K02759,K03478 - 2.7.1.196,2.7.1.205,3.5.1.105 0.0000000000000000000000000000000001077 147.0
HKD2_k127_7800653_0 LUD domain - - - 5.653e-216 707.0
HKD2_k127_7800653_1 PFAM FAD linked oxidase domain protein K00102,K00104 - 1.1.2.4,1.1.3.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 548.0
HKD2_k127_7800653_2 L-lactate dehydrogenase K00101,K16422 - 1.1.2.3,1.1.3.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007683 470.0
HKD2_k127_7800653_3 Cysteine-rich domain K11473 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004792 408.0
HKD2_k127_7800653_4 regulator IclR K13641 - - 0.0000000000000000000000000000000000000000000000000000006098 202.0
HKD2_k127_7800653_5 PFAM FAD linked oxidase domain protein K00102,K00104,K11472 - 1.1.2.4,1.1.3.15 0.00000000000000000000000000000000000000000001913 187.0
HKD2_k127_7800653_6 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.000000389 53.0
HKD2_k127_7801851_0 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008512 492.0
HKD2_k127_7801851_1 PFAM Phenylalanine and histidine ammonia-lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008106 477.0
HKD2_k127_7801851_10 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000004093 164.0
HKD2_k127_7801851_11 Ferric reductase like transmembrane component K17247 - - 0.000000000000000001648 95.0
HKD2_k127_7801851_12 - - - - 0.000000002912 67.0
HKD2_k127_7801851_2 Belongs to the peptidase S51 family K05995 - 3.4.13.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007353 339.0
HKD2_k127_7801851_3 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002698 332.0
HKD2_k127_7801851_4 PFAM Haloacid dehalogenase domain protein hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001145 287.0
HKD2_k127_7801851_5 Two component transcriptional regulator, winged helix family K07669,K07672 GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010446,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0023052,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0035556,GO:0043254,GO:0044087,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004674 269.0
HKD2_k127_7801851_6 proline dipeptidase activity K01262 - 3.4.11.9 0.000000000000000000000000000000000000000000000000000000000000000000000000001152 268.0
HKD2_k127_7801851_7 Methyladenine glycosylase K01246 - 3.2.2.20 0.0000000000000000000000000000000000000000000000000000000006738 209.0
HKD2_k127_7801851_8 Transcriptional regulatory protein, C terminal K07670 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016310,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.000000000000000000000000000000000000000000000000001982 191.0
HKD2_k127_7801851_9 STAS-like domain of unknown function (DUF4325) - - - 0.000000000000000000000000000000000000000000000006555 190.0
HKD2_k127_7805272_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 2.738e-196 628.0
HKD2_k127_7805272_1 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000145 204.0
HKD2_k127_7805272_2 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.000000000000000000000000132 113.0
HKD2_k127_7826369_0 DNA polymerase Ligase (LigD) K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 581.0
HKD2_k127_7826369_1 Bacterial protein of unknown function (DUF885) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000648 469.0
HKD2_k127_7826369_2 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 GO:0000726,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050790,GO:0050896,GO:0051340,GO:0051351,GO:0051716,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000000000002117 220.0
HKD2_k127_7826369_3 Two component transcriptional regulator, winged helix family K02483 - - 0.000000000000000000000000000000000000000000000000000000000002377 218.0
HKD2_k127_7826369_4 dna ligase K01971 - 6.5.1.1 0.00000000000000000000000000000004851 137.0
HKD2_k127_7826369_5 hydrolase of the alpha beta-hydrolase fold K07020 - - 0.0000000003012 71.0
HKD2_k127_7826369_6 Response regulator receiver domain protein K07670 GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016310,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044110,GO:0044116,GO:0044117,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - 0.00003266 51.0
HKD2_k127_7826421_0 TIGRFAM Na Pi-cotransporter II-related protein K03324 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003937 370.0
HKD2_k127_7826421_1 Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate K01647 - 2.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 322.0
HKD2_k127_7826421_2 COGs COG1801 conserved - - - 0.0000000000000000000000000000000000000002563 156.0
HKD2_k127_7826421_3 amino acid activation for nonribosomal peptide biosynthetic process - - - 0.00000000004111 74.0
HKD2_k127_783572_0 Stage II sporulation D domain protein K06381 - - 0.00000000000000000000000000000000000000000000001394 191.0
HKD2_k127_783572_1 Histidine kinase K07777 - 2.7.13.3 0.0000000000000000000000000000000000000001166 167.0
HKD2_k127_783572_2 Two component transcriptional regulator, LuxR family - - - 0.00000000000000000000000000000000000000876 147.0
HKD2_k127_783572_3 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.000000000000000000000000000000001618 130.0
HKD2_k127_783572_4 DinB superfamily - - - 0.0000000000005777 81.0
HKD2_k127_7854391_0 Belongs to the ABC transporter superfamily K10823 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006969 506.0
HKD2_k127_7854391_1 Belongs to the ABC transporter superfamily K15583 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 478.0
HKD2_k127_7854391_2 Bacterial extracellular solute-binding proteins, family 5 Middle K15580 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 466.0
HKD2_k127_7854391_3 PFAM binding-protein-dependent transport systems inner membrane component K15582 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004194 308.0
HKD2_k127_7854391_4 Binding-protein-dependent transport system inner membrane component K15581 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000007993 287.0
HKD2_k127_7854391_5 ABC transporter substrate-binding protein K02035 - - 0.0000000000000000000000000000000000002597 158.0
HKD2_k127_7860070_0 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002495 449.0
HKD2_k127_7860070_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K03737 - 1.2.7.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003502 406.0
HKD2_k127_7929044_0 PFAM Uncharacterised protein family UPF0182 K09118 - - 1.137e-202 665.0
HKD2_k127_7929044_1 Belongs to the DEAD box helicase family K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 355.0
HKD2_k127_7929044_10 HIT domain - - - 0.000000000000000000000000000000000000000001919 160.0
HKD2_k127_7929044_11 Bacteriocin-protection, YdeI or OmpD-Associated - - - 0.00000000000000000000000000000000000004916 151.0
HKD2_k127_7929044_12 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000002571 147.0
HKD2_k127_7929044_13 Belongs to the acetyltransferase family. ArgA subfamily K03830 - - 0.0000000000000000000000000001054 121.0
HKD2_k127_7929044_14 PFAM PpiC-type peptidyl-prolyl cis-trans isomerase K03770 - 5.2.1.8 0.000000000000000001424 101.0
HKD2_k127_7929044_15 Acetyltransferase (GNAT) family - - - 0.00000000000000002529 94.0
HKD2_k127_7929044_16 AAA domain - - - 0.000000000000007493 85.0
HKD2_k127_7929044_18 TonB-dependent Receptor Plug - - - 0.0004181 48.0
HKD2_k127_7929044_2 Methyltransferase FkbM domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 305.0
HKD2_k127_7929044_3 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000392 275.0
HKD2_k127_7929044_4 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000001055 270.0
HKD2_k127_7929044_5 GtrA-like protein K00721 - 2.4.1.83 0.0000000000000000000000000000000000000000000000000000000000000002132 233.0
HKD2_k127_7929044_6 Protein of unknown function, DUF488 - - - 0.0000000000000000000000000000000000000000000000000000006969 198.0
HKD2_k127_7929044_7 MazG nucleotide pyrophosphohydrolase domain K02428,K02499,K04765 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66,3.6.1.9 0.00000000000000000000000000000000000000000000000000000103 206.0
HKD2_k127_7929044_8 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000007304 185.0
HKD2_k127_7929044_9 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000001654 170.0
HKD2_k127_7938762_0 PFAM glycosyl transferase family 3 K00756 - 2.4.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 456.0
HKD2_k127_7938762_1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate K03783 - 2.4.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002821 309.0
HKD2_k127_7938762_2 RNA pseudouridylate synthase K06178,K06181 GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.20,5.4.99.22 0.000000000000000000000000000000000000000000000000000000001093 219.0
HKD2_k127_7938762_3 PFAM peptidase - - - 0.00000000000000000000000000000000000000006523 160.0
HKD2_k127_7938762_4 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.0000000000000000000000000000000000000009486 152.0
HKD2_k127_7938762_5 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.000000000000000000000000000000000000006752 156.0
HKD2_k127_7938762_6 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 GO:0003674,GO:0005488,GO:0005515,GO:0042802 - 0.0000000000000008503 87.0
HKD2_k127_7977448_0 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000002624 216.0
HKD2_k127_7977448_1 PFAM Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000002774 202.0
HKD2_k127_7977448_2 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.00000000000000000000000000000000000000000000002026 176.0
HKD2_k127_7977448_3 Bifunctional nuclease K08999 - - 0.00000000000000000000000000000006251 130.0
HKD2_k127_7977448_4 PFAM glycosyl transferase family 2 - - - 0.00000000000000000000000004503 111.0
HKD2_k127_7977448_5 amine dehydrogenase activity - - - 0.000222 55.0
HKD2_k127_8019094_0 TIGRFAM conserved repeat domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006738 575.0
HKD2_k127_8019094_1 Type ii secretion system protein e K02283 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004062 509.0
HKD2_k127_8019094_10 PFAM TadE family protein - - - 0.000000000000000000000000006916 128.0
HKD2_k127_8019094_11 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000005107 124.0
HKD2_k127_8019094_12 Histidine kinase-like ATPases - - - 0.000000000000000000001929 108.0
HKD2_k127_8019094_13 Flp pilus assembly protein RcpC/CpaB K02279 - - 0.00000000000000000002188 102.0
HKD2_k127_8019094_14 Conserved repeat domain - - - 0.00000000006936 77.0
HKD2_k127_8019094_15 response regulator - - - 0.0000000001083 74.0
HKD2_k127_8019094_16 helix_turn_helix, Lux Regulon - - - 0.00000001209 64.0
HKD2_k127_8019094_17 protein secretion K03116 - - 0.000000031 57.0
HKD2_k127_8019094_18 PFAM TadE family protein - - - 0.00000005989 60.0
HKD2_k127_8019094_19 helix_turn_helix, Lux Regulon - - - 0.0000002608 61.0
HKD2_k127_8019094_2 Major Facilitator Superfamily K08177 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002182 417.0
HKD2_k127_8019094_20 PFAM Flp Fap pilin component K02651 - - 0.000006558 49.0
HKD2_k127_8019094_21 TadE-like protein - - - 0.00002338 55.0
HKD2_k127_8019094_3 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03605 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 322.0
HKD2_k127_8019094_4 von Willebrand factor (vWF) type A domain K07114,K12511 - - 0.00000000000000000000000000000000000000000000000000002914 210.0
HKD2_k127_8019094_5 PFAM response regulator receiver K02282 - - 0.00000000000000000000000000000000000000000000002926 185.0
HKD2_k127_8019094_6 Type II secretion system (T2SS), protein F K12510 - - 0.00000000000000000000000000000000000000000001078 179.0
HKD2_k127_8019094_7 response regulator - - - 0.00000000000000000000000000000000002045 147.0
HKD2_k127_8019094_8 - - - - 0.0000000000000000000000000000000003307 154.0
HKD2_k127_8019094_9 Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms K04567 - 6.1.1.6 0.0000000000000000000000000005258 118.0
HKD2_k127_8061519_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 4.393e-204 648.0
HKD2_k127_8061519_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003006 276.0
HKD2_k127_8061519_2 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.0000000000000000000000000000000000000000000000962 175.0
HKD2_k127_8061519_3 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.00000000000000000000000000000000181 138.0
HKD2_k127_8061519_4 Iron permease FTR1 family K07243 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000005164 126.0
HKD2_k127_8061519_5 TIGRFAM 40-residue YVTN family beta-propeller repeat protein - - - 0.0000000000000000003992 100.0
HKD2_k127_8061519_6 NUDIX domain - - - 0.0000000000000003276 84.0
HKD2_k127_8132519_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 3.868e-215 705.0
HKD2_k127_8132519_1 Animal haem peroxidase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005374 490.0
HKD2_k127_8132519_10 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family K07402 - - 0.000000000000000000000000000000000000000000000000000000002848 213.0
HKD2_k127_8132519_11 PFAM 2Fe-2S -binding K03518,K07302,K13483 - 1.2.5.3,1.3.99.16 0.0000000000000000000000000000000000000000000000000000003852 198.0
HKD2_k127_8132519_12 Acetyltransferase (GNAT) domain K03823 - 2.3.1.183 0.000000000000000000000000000000000000000000000000006934 190.0
HKD2_k127_8132519_13 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567 - 2.1.1.63 0.0000000000000000000000000000000000000000000233 171.0
HKD2_k127_8132519_14 - - - - 0.00000000000000000000000000000000000000000002489 179.0
HKD2_k127_8132519_15 Nudix hydrolase K03574 - 3.6.1.55 0.000000000000000000000000000000000002493 143.0
HKD2_k127_8132519_16 YCII-related domain - - - 0.00000000000000000000004642 102.0
HKD2_k127_8132519_17 YCII-related domain - - - 0.00000000000000006981 90.0
HKD2_k127_8132519_18 -acetyltransferase K03828,K17840 - 2.3.1.59 0.000000000000001489 86.0
HKD2_k127_8132519_19 TIGRFAM MoaD family protein K03636 - - 0.000000000000008309 80.0
HKD2_k127_8132519_2 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001183 461.0
HKD2_k127_8132519_20 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000004154 76.0
HKD2_k127_8132519_21 YCII-related domain - - - 0.000000000001522 79.0
HKD2_k127_8132519_22 acetyltransferase - - - 0.0002797 53.0
HKD2_k127_8132519_3 Aminotransferase class-V - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008768 429.0
HKD2_k127_8132519_4 ATPases associated with a variety of cellular activities - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006941 390.0
HKD2_k127_8132519_5 GlcNAc-PI de-N-acetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008806 352.0
HKD2_k127_8132519_6 Amidohydrolase K03392 - 4.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005723 292.0
HKD2_k127_8132519_7 cellulose binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004093 263.0
HKD2_k127_8132519_8 CO dehydrogenase flavoprotein C-terminal domain K11178 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000003549 258.0
HKD2_k127_8132519_9 Uncharacterized protein family UPF0016 - - - 0.0000000000000000000000000000000000000000000000000000000003359 211.0
HKD2_k127_8133295_0 Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway K16329 - 4.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000001999 269.0
HKD2_k127_8133295_1 Belongs to the peptidase M50B family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003785 257.0
HKD2_k127_8133295_2 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000004547 218.0
HKD2_k127_8133295_3 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.000000000000000000000000000000000000000000000000001034 187.0
HKD2_k127_8133295_4 TIGRFAM glutaredoxin-like domain protein - - - 0.000000000000000000000000000000000000001044 155.0
HKD2_k127_8133295_5 TIGRFAM molybdenum cofactor synthesis domain - - - 0.000000000000000000000000000000000000001901 158.0
HKD2_k127_8133295_6 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.000000000000000000000000000000001297 134.0
HKD2_k127_8133295_7 negative regulation of transcription, DNA-templated K21600 - - 0.00000000008929 71.0
HKD2_k127_8142746_0 Belongs to the argininosuccinate synthase family. Type K01940 - 6.3.4.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001321 506.0
HKD2_k127_8142746_1 TIGRFAM argininosuccinate lyase K01755 - 4.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006995 441.0
HKD2_k127_8142746_10 Regulates arginine biosynthesis genes K03402 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.000000000000000000009697 104.0
HKD2_k127_8142746_11 PFAM peptidase M16 domain protein K07263 - - 0.00000000000001253 88.0
HKD2_k127_8142746_12 Belongs to the Glu Leu Phe Val dehydrogenases family K00261 - 1.4.1.3 0.0000000000001255 72.0
HKD2_k127_8142746_13 helix_turn_helix multiple antibiotic resistance protein - - - 0.0002362 49.0
HKD2_k127_8142746_2 Gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 410.0
HKD2_k127_8142746_3 NTF2-like N-terminal transpeptidase domain K05515 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002855 398.0
HKD2_k127_8142746_4 Insulinase (Peptidase family M16) K07263 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000335 347.0
HKD2_k127_8142746_5 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 342.0
HKD2_k127_8142746_6 SERine Proteinase INhibitors K13963 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007665 323.0
HKD2_k127_8142746_7 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006127 310.0
HKD2_k127_8142746_8 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.000000000000000000000000000000000000000000000000001614 193.0
HKD2_k127_8142746_9 PFAM GCN5-related N-acetyltransferase K00619 - 2.3.1.1 0.0000000000000000000000000000000000006327 145.0
HKD2_k127_8144496_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000135 454.0
HKD2_k127_8144496_1 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 348.0
HKD2_k127_8144496_10 Putative heavy-metal-binding - - - 0.00000000000000000000000000000000000009596 145.0
HKD2_k127_8144496_11 Acetyltransferase (GNAT) domain - - - 0.000000002104 68.0
HKD2_k127_8144496_2 Pyridoxal-phosphate dependent enzyme K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001267 331.0
HKD2_k127_8144496_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002522 312.0
HKD2_k127_8144496_4 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 - 5.1.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000001354 272.0
HKD2_k127_8144496_5 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000004391 215.0
HKD2_k127_8144496_6 Histidine biosynthesis bifunctional protein hisIE K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000001074 190.0
HKD2_k127_8144496_7 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000001351 180.0
HKD2_k127_8144496_8 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000002283 190.0
HKD2_k127_8144496_9 PFAM Haloacid dehalogenase domain protein hydrolase K07025,K20862 - 3.1.3.102,3.1.3.104 0.000000000000000000000000000000000000000002413 165.0
HKD2_k127_8172474_0 Amidohydrolase family K06015 - 3.5.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004727 581.0
HKD2_k127_8172474_1 FAD linked oxidases, C-terminal domain K00104 - 1.1.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 446.0
HKD2_k127_8172474_2 Cysteine-rich domain K11473 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 305.0
HKD2_k127_8172474_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001612 246.0
HKD2_k127_8172474_4 - - - - 0.0002886 50.0
HKD2_k127_8197317_0 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001794 377.0
HKD2_k127_8197317_1 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 352.0
HKD2_k127_8197317_2 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.000000000000000000000000000000000000000000000001965 182.0
HKD2_k127_8197317_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000003787 172.0
HKD2_k127_8197317_4 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - 0.000000000000000000000000000001873 124.0
HKD2_k127_8197317_5 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000005224 76.0
HKD2_k127_8197317_6 Belongs to the bacterial ribosomal protein bL35 family K02916 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000002225 72.0
HKD2_k127_8201187_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K04105,K04110 - 6.2.1.25,6.2.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001013 488.0
HKD2_k127_8201187_1 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00303 - 1.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006583 458.0
HKD2_k127_8201187_2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001332 382.0
HKD2_k127_8201187_3 Major facilitator superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001931 261.0
HKD2_k127_8201187_4 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000005816 185.0
HKD2_k127_8201187_5 Dehydrogenase K00087,K03518 - 1.17.1.4,1.2.5.3 0.0000000000000000000000000000000000000000000136 169.0
HKD2_k127_8201187_6 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.000000000000000000000000000000000000199 160.0
HKD2_k127_8201187_7 Carbon monoxide dehydrogenase subunit G (CoxG) - - - 0.0000000000000000000003795 101.0
HKD2_k127_8201187_8 Thiopurine S-methyltransferase (TPMT) - - - 0.0002299 47.0
HKD2_k127_8263284_0 histone deacetylase K04768 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001644 287.0
HKD2_k127_8263284_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009125,GO:0009129,GO:0009130,GO:0009131,GO:0009157,GO:0009159,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009178,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0032259,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042083,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046073,GO:0046078,GO:0046079,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.1.1.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001154 291.0
HKD2_k127_8263284_2 Dihydrofolate reductase K00287 - 1.5.1.3 0.00000000000000000000000000000000000000000000000004749 192.0
HKD2_k127_8263284_3 Beta-lactamase - - - 0.0000000000000000000000000000000000000007348 156.0
HKD2_k127_834877_0 Elongation factor SelB, winged helix K03833 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001837 522.0
HKD2_k127_834877_1 Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis K01042 - 2.9.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001373 419.0
HKD2_k127_834877_2 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005148 351.0
HKD2_k127_834877_3 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 0.00000000000000000000000000000000000000000000001244 176.0
HKD2_k127_834877_4 PFAM diacylglycerol kinase catalytic region - - - 0.00000000000000000000000000000000000000000000002161 183.0
HKD2_k127_834877_5 Endoribonuclease L-PSP K09021,K09022 GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0017144,GO:0019740,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.99.10 0.00000000000000000000000000000000000000000007373 162.0
HKD2_k127_834877_6 Protein of unknown function (DUF4446) - - - 0.000000000000000000000002261 108.0
HKD2_k127_8366983_0 ATPases associated with a variety of cellular activities K01990,K09689,K09691,K09693 - 3.6.3.38,3.6.3.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008496 338.0
HKD2_k127_8366983_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000001234 248.0
HKD2_k127_8366983_2 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000001308 223.0
HKD2_k127_8366983_3 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000004864 202.0
HKD2_k127_8366983_4 Methionine biosynthesis protein MetW K18827 - 2.1.1.294,2.7.1.181 0.000000000000000000000000000009654 138.0
HKD2_k127_8366983_5 Carboxypeptidase regulatory-like domain - - - 0.0000000000001211 85.0
HKD2_k127_8366983_6 Glycosyl transferases group 1 - - - 0.000000000004342 77.0
HKD2_k127_8386396_0 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00169,K19070 GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002715 563.0
HKD2_k127_8386396_1 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009853 521.0
HKD2_k127_8386396_10 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001892 275.0
HKD2_k127_8386396_11 COG0530 Ca2 Na antiporter K07301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000006995 261.0
HKD2_k127_8386396_12 Tripartite tricarboxylate transporter family receptor K07795 - - 0.0000000000000000000000000000000000000000000000000000000001299 218.0
HKD2_k127_8386396_13 GDP-mannose mannosyl hydrolase activity K03574,K13669 - 3.6.1.55 0.000000000000000000000000000000000000000000000000009 184.0
HKD2_k127_8386396_14 PFAM ABC-2 type transporter K01992 - - 0.00000000000000000000000000000000000000000000001593 184.0
HKD2_k127_8386396_15 cell envelope-related transcriptional attenuator - - - 0.0000000000000000000000000000000000000000000001535 190.0
HKD2_k127_8386396_16 Regulatory protein GntR HTH K05799 - - 0.00000000000000000000000000000000000000000001143 171.0
HKD2_k127_8386396_17 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.0000000000000000000000000005866 119.0
HKD2_k127_8386396_18 Tripartite tricarboxylate transporter TctB family - - - 0.00000001782 63.0
HKD2_k127_8386396_2 Tripartite tricarboxylate transporter TctA family K07793 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001264 500.0
HKD2_k127_8386396_3 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00170,K19071 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 491.0
HKD2_k127_8386396_4 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 384.0
HKD2_k127_8386396_5 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor K00171,K00172,K19072 GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575 1.2.7.1,1.2.7.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003236 370.0
HKD2_k127_8386396_6 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000443 317.0
HKD2_k127_8386396_7 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000453 303.0
HKD2_k127_8386396_8 5,10-methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 300.0
HKD2_k127_8386396_9 PFAM Basic membrane lipoprotein K07335 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004599 300.0
HKD2_k127_8399459_0 PFAM DAHP synthetase I KDSA K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008475 416.0
HKD2_k127_8399459_1 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000006327 222.0
HKD2_k127_8399459_2 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000003837 221.0
HKD2_k127_8399459_3 PFAM Chorismate mutase of the AroH class K06208 - 5.4.99.5 0.00000000000000000000000000000000001205 142.0
HKD2_k127_8399459_4 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K04517 - 1.3.1.12 0.00000000000000000000000000135 122.0
HKD2_k127_8410495_0 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005733 457.0
HKD2_k127_8410495_1 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001412 382.0
HKD2_k127_8410495_10 Protein of unknown function (DUF1290) - - - 0.00000000000000000000000000004942 117.0
HKD2_k127_8410495_11 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000003377 120.0
HKD2_k127_8410495_12 PFAM OsmC family protein - - - 0.00000000000000000000000001273 114.0
HKD2_k127_8410495_13 Catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate K22292 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.105 0.000000000000000000009111 102.0
HKD2_k127_8410495_14 Stress-responsive transcriptional regulator K03973 - - 0.0000000000000002916 85.0
HKD2_k127_8410495_15 Transcriptional regulator K10914 - - 0.00000000000107 75.0
HKD2_k127_8410495_16 integral membrane protein K02221 - - 0.0000000005919 69.0
HKD2_k127_8410495_18 Belongs to the UPF0235 family K09131 - - 0.00000004452 61.0
HKD2_k127_8410495_19 nuclear chromosome segregation - - - 0.000000178 61.0
HKD2_k127_8410495_2 Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005955 376.0
HKD2_k127_8410495_20 - - - - 0.000001007 60.0
HKD2_k127_8410495_21 PFAM Cytochrome C - - - 0.00004768 52.0
HKD2_k127_8410495_3 Predicted membrane protein (DUF2207) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001052 350.0
HKD2_k127_8410495_4 Belongs to the dCTP deaminase family K01494 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0019239,GO:0033973,GO:0047429 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000819 264.0
HKD2_k127_8410495_5 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000002175 238.0
HKD2_k127_8410495_6 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000002232 212.0
HKD2_k127_8410495_7 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000215 208.0
HKD2_k127_8410495_8 Histidine kinase - - - 0.0000000000000000000000000000000000000000000003916 183.0
HKD2_k127_8410495_9 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.00000000000000000000000000000000001373 144.0
HKD2_k127_8438479_0 Glycogen debranching enzyme - - - 0.0 1083.0
HKD2_k127_8438479_1 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005972 523.0
HKD2_k127_8438479_10 domain protein - - - 0.00000000000000000005451 99.0
HKD2_k127_8438479_11 helix_turn_helix, Lux Regulon - - - 0.0000000001614 70.0
HKD2_k127_8438479_12 ATPase, P-type (transporting), HAD superfamily, subfamily IC K17686 - 3.6.3.54 0.000000005418 61.0
HKD2_k127_8438479_13 Prokaryotic cytochrome b561 - - - 0.0000004994 61.0
HKD2_k127_8438479_2 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001567 384.0
HKD2_k127_8438479_3 Selenium-dependent molybdenum hydroxylase system protein, YqeB family K07402 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007495 326.0
HKD2_k127_8438479_4 Enoyl-(Acyl carrier protein) reductase K00034 - 1.1.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002858 278.0
HKD2_k127_8438479_5 xanthine dehydrogenase activity K11178 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000001744 238.0
HKD2_k127_8438479_6 [2Fe-2S] binding domain K03518 - 1.2.5.3 0.000000000000000000000000000000000000000000000000002245 189.0
HKD2_k127_8438479_7 amine dehydrogenase activity K09815 - - 0.0000000000000000000000000000000000000000000000002022 190.0
HKD2_k127_8438479_8 Involved in chromosome partitioning - - - 0.00000000000000000000000000000000000001597 154.0
HKD2_k127_8438479_9 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.00000000000000000000000000000626 126.0
HKD2_k127_8444178_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 546.0
HKD2_k127_8444178_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009136 530.0
HKD2_k127_8444178_2 acetyltransferase - - - 0.000000000042 73.0
HKD2_k127_8449952_0 C-terminal, D2-small domain, of ClpB protein K03696 - - 1.324e-321 1004.0
HKD2_k127_8449952_1 Voltage gated chloride channel K03281 - - 5.03e-225 717.0
HKD2_k127_8449952_10 Ribosomal protein S1 K02945 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000008378 255.0
HKD2_k127_8449952_11 PFAM ABC transporter related K02003 - - 0.0000000000000000000000000000000000000000000000000000000000002786 220.0
HKD2_k127_8449952_12 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000002106 229.0
HKD2_k127_8449952_13 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000006659 190.0
HKD2_k127_8449952_14 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase K01057 - 3.1.1.31 0.00000000000000000000000000000000000000000000000009656 184.0
HKD2_k127_8449952_15 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - 0.000000000000000000000000000000000001204 157.0
HKD2_k127_8449952_16 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.00000000000000000000000000000004986 137.0
HKD2_k127_8449952_17 F420H(2)-dependent quinone reductase - - - 0.0000000000000000000002086 113.0
HKD2_k127_8449952_18 DJ-1/PfpI family - - - 0.0001565 53.0
HKD2_k127_8449952_2 luxR family - - - 5.268e-196 623.0
HKD2_k127_8449952_3 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 558.0
HKD2_k127_8449952_4 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003211 502.0
HKD2_k127_8449952_5 GMC oxidoreductase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001784 433.0
HKD2_k127_8449952_6 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001092 415.0
HKD2_k127_8449952_7 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 323.0
HKD2_k127_8449952_8 SMART Nucleotide binding protein, PINc - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005291 293.0
HKD2_k127_8449952_9 transporter K07238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003857 271.0
HKD2_k127_8457424_0 GTP cyclohydrolase I - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000008586 278.0
HKD2_k127_8457424_1 nitrite reductase [NAD(P)H] activity - - - 0.0000000000000000000000000000000000000000000000000004634 195.0
HKD2_k127_8457424_2 Metallo-beta-lactamase superfamily K13075 - 3.1.1.81 0.000000000000000000000000000000000000000000000000001302 191.0
HKD2_k127_8457424_3 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000006665 183.0
HKD2_k127_8457424_4 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K00082,K11752 - 1.1.1.193,3.5.4.26 0.00000000000000000000000000000000000000000001976 178.0
HKD2_k127_8457424_5 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000000000001528 90.0
HKD2_k127_8502995_0 acetyl-CoA carboxylase, biotin carboxylase K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007128 317.0
HKD2_k127_8502995_1 Belongs to the arginase family K01476 GO:0003674,GO:0003824,GO:0004053,GO:0006082,GO:0006520,GO:0006525,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 3.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001039 304.0
HKD2_k127_8502995_2 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000000000000000000000000000000000000001862 151.0
HKD2_k127_8502995_3 Ankyrin repeat K06867 - - 0.0000000000000000000000000001144 125.0
HKD2_k127_8522353_0 Peptidase dimerisation domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007807 489.0
HKD2_k127_8522353_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002484 452.0
HKD2_k127_8522353_10 DoxX K16937 - 1.8.5.2 0.000000000000000000000000000000000000000000000000005267 192.0
HKD2_k127_8522353_11 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000000000000000000002651 182.0
HKD2_k127_8522353_12 GyrI-like small molecule binding domain - - - 0.000000000000000000000000000000000000000000004109 173.0
HKD2_k127_8522353_13 Belongs to the carbamate kinase family K00926 - 2.7.2.2 0.000000000000000000000000000000000000000000006604 176.0
HKD2_k127_8522353_14 histidine kinase, dimerisation and phosphoacceptor region - - - 0.00000000000000000000000000000000000000002986 164.0
HKD2_k127_8522353_15 bacterial OsmY and nodulation domain - - - 0.000000000000000000000000000000000000004836 156.0
HKD2_k127_8522353_16 Pyridoxamine 5'-phosphate oxidase K07005 - - 0.00000000000000000000000000000000001942 140.0
HKD2_k127_8522353_17 membrane - - - 0.00000000000000000000000000000000003316 140.0
HKD2_k127_8522353_18 COG COG0589 Universal stress protein UspA and related nucleotide-binding proteins Signal transduction mechanisms - - - 0.00000000000000000000000171 114.0
HKD2_k127_8522353_19 Prokaryotic dksA/traR C4-type zinc finger - - - 0.0000000000000000001689 97.0
HKD2_k127_8522353_2 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002044 359.0
HKD2_k127_8522353_20 Diacylglycerol kinase catalytic domain (presumed) - - - 0.0000000000000000003863 101.0
HKD2_k127_8522353_21 Domain of unknown function (DUF4342) - - - 0.000000000000001677 82.0
HKD2_k127_8522353_22 Belongs to the universal stress protein A family - - - 0.000000000000003554 86.0
HKD2_k127_8522353_23 Universal stress protein family - - - 0.0000000000002428 80.0
HKD2_k127_8522353_24 negative regulation of growth - - - 0.000000003467 63.0
HKD2_k127_8522353_25 Cation transport ATPase K17686 - 3.6.3.54 0.00000133 54.0
HKD2_k127_8522353_26 Lysin motif - - - 0.000006975 58.0
HKD2_k127_8522353_3 VIT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009749 355.0
HKD2_k127_8522353_4 Von Willebrand factor type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002413 307.0
HKD2_k127_8522353_5 histidine kinase, dimerisation and phosphoacceptor region - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003431 296.0
HKD2_k127_8522353_6 Uracil DNA glycosylase superfamily K21929 - 3.2.2.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003095 274.0
HKD2_k127_8522353_7 response regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000002667 227.0
HKD2_k127_8522353_8 Response regulator receiver - - - 0.0000000000000000000000000000000000000000000000000001598 197.0
HKD2_k127_8522353_9 Trypsin-like peptidase domain - - - 0.000000000000000000000000000000000000000000000000001314 194.0
HKD2_k127_8534033_0 PFAM transferase hexapeptide repeat containing protein K16881 - 2.7.7.13,5.4.2.8 1.58e-280 884.0
HKD2_k127_8534033_1 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005904 441.0
HKD2_k127_8534033_10 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000008401 198.0
HKD2_k127_8534033_11 D-alanyl-D-alanine carboxypeptidase K07260 - 3.4.17.14 0.000000000000000000000000000000000000000000000000000007352 203.0
HKD2_k127_8534033_12 NIPSNAP - - - 0.0000000000000000000000000000000000000002477 164.0
HKD2_k127_8534033_13 Beta-lactamase - - - 0.00000000000000000000000000001895 137.0
HKD2_k127_8534033_14 Lrp/AsnC ligand binding domain - - - 0.0000000000000000000000000009925 116.0
HKD2_k127_8534033_15 heme oxygenase (decyclizing) activity - - - 0.0000000000000000000000344 102.0
HKD2_k127_8534033_16 of nitrite reductase and ring-hydroxylating K05710 - - 0.00000000000000000003223 101.0
HKD2_k127_8534033_17 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - 0.0000000000000000002554 91.0
HKD2_k127_8534033_18 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000004789 92.0
HKD2_k127_8534033_19 Immunoglobulin-like domain of bacterial spore germination - - - 0.000000000000005352 84.0
HKD2_k127_8534033_2 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006747 362.0
HKD2_k127_8534033_21 Crp-like helix-turn-helix domain - - - 0.0002994 52.0
HKD2_k127_8534033_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source K01916 - 6.3.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003265 315.0
HKD2_k127_8534033_4 ligase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 310.0
HKD2_k127_8534033_5 Uncharacterized protein family (UPF0051) K09014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006389 257.0
HKD2_k127_8534033_6 esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003887 261.0
HKD2_k127_8534033_7 Carbon-nitrogen hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007231 252.0
HKD2_k127_8534033_8 Uncharacterized protein family (UPF0051) K09015 - - 0.000000000000000000000000000000000000000000000000000000000000000002207 244.0
HKD2_k127_8534033_9 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.00000000000000000000000000000000000000000000000000000000000000005015 232.0
HKD2_k127_8593330_0 chromosome segregation K03497 - - 0.000000000000000000000000000000000000000000000000000000000000000000003214 248.0
HKD2_k127_8593330_1 GAF domain - - - 0.00000000000000000000000000000000000000000000000000000003074 213.0
HKD2_k127_8593330_2 RIO1 family K07178 - 2.7.11.1 0.0000000000000000000000000000000000000003595 160.0
HKD2_k127_8593330_3 PFAM response regulator receiver - - - 0.000000000000000000000000000006951 124.0
HKD2_k127_8635562_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 470.0
HKD2_k127_8635562_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007704 467.0
HKD2_k127_8635562_2 TIGRFAM gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008954 447.0
HKD2_k127_8882663_0 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003951 381.0
HKD2_k127_8882663_1 Protein of unknown function DUF72 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001371 308.0
HKD2_k127_8882663_2 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate K00761 - 2.4.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000258 285.0
HKD2_k127_8882663_3 transferase K02851 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914 2.7.8.33,2.7.8.35 0.0000000000000000000000000000000000000000000000000000000000000004549 234.0
HKD2_k127_8882663_4 ATP-binding region, ATPase domain protein K02487,K03407,K06596 - 2.7.13.3 0.000000000000002405 84.0
HKD2_k127_8882663_5 Hint domain - - - 0.00001387 57.0
HKD2_k127_8882663_6 - - - - 0.000031 53.0
HKD2_k127_8882663_7 Serine aminopeptidase, S33 - - - 0.00004497 55.0
HKD2_k127_8987764_0 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007591 290.0
HKD2_k127_8987764_1 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004885 263.0
HKD2_k127_8987764_2 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000009432 253.0
HKD2_k127_8987764_3 Ribosomal L28 family K02902 - - 0.0000003244 56.0
HKD2_k127_8987764_4 Dak1_2 K07030 - - 0.0002948 47.0
HKD2_k127_8989099_0 PFAM glycosyl hydrolase BNR repeat-containing protein - - - 0.0 1393.0
HKD2_k127_8989099_1 Delta-aminolevulinic acid dehydratase K01698 - 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004876 377.0
HKD2_k127_8989099_2 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001016 281.0
HKD2_k127_8989099_3 Radical SAM - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001553 257.0
HKD2_k127_8989099_4 PFAM thioesterase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000003076 226.0
HKD2_k127_8989099_5 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0040007,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.000000000000000000000000000000000000000000000000000000000005729 225.0
HKD2_k127_8989099_6 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000006137 169.0
HKD2_k127_8989099_7 3-demethylubiquinone-9 3-O-methyltransferase activity K03428 - 2.1.1.11 0.00000000000000000000000000000000000000006287 160.0
HKD2_k127_8989099_8 FtsZ-dependent cytokinesis - - - 0.000000000000005121 85.0
HKD2_k127_8989099_9 Uroporphyrinogen-III synthase K01719 GO:0003674,GO:0003824,GO:0004852,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009507,GO:0009536,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.75 0.000000009025 66.0
HKD2_k127_9027433_0 transferase activity, transferring glycosyl groups K09118,K13693,K21349 - 2.4.1.266,2.4.1.268 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003947 499.0
HKD2_k127_9027433_1 Amylo-alpha-1,6-glucosidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009769 464.0
HKD2_k127_9027433_2 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000001114 278.0
HKD2_k127_9027433_3 Glycosyltransferase Family 4 K21369 - 2.4.1.270 0.00000000000000000000000000000000000000000000000000000000000005039 231.0
HKD2_k127_9027433_4 Bacterial regulatory proteins, tetR family - - - 0.00000001368 58.0
HKD2_k127_9068093_0 Neutral zinc metallopeptidase K07054 GO:0005575,GO:0005576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003009 323.0
HKD2_k127_9068093_1 GMC oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006287 309.0
HKD2_k127_9068093_2 Cytochrome c K00406,K03889 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000003936 199.0
HKD2_k127_9068093_3 Sodium/calcium exchanger protein K07300 - - 0.00000000000000000000000000000000000000000000000001894 195.0
HKD2_k127_9068093_4 YceI-like domain - - - 0.000000000000000000000000000000000001548 147.0
HKD2_k127_9068093_5 Pfam:DUF385 - - - 0.0000000000000000000000000000000001931 146.0
HKD2_k127_9068093_6 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.0000000000000158 73.0
HKD2_k127_9092777_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001853 327.0
HKD2_k127_9092777_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766,K13497 GO:0000162,GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0004048,GO:0004049,GO:0004425,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016829,GO:0016830,GO:0016831,GO:0016833,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042401,GO:0042430,GO:0042435,GO:0042451,GO:0042455,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046129,GO:0046219,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901657,GO:1901659,GO:1902494 2.4.2.18,4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007427 329.0
HKD2_k127_9092777_2 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004064 278.0
HKD2_k127_9092777_3 Peptidase C26 K01658,K01664 GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 0.0000000000000000000000000000000000000000000000000000001982 207.0
HKD2_k127_9092777_4 Indole-3-glycerol phosphate synthase K01609 GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 0.000000000000000000000000000000000000000000123 173.0
HKD2_k127_9146127_0 Prolyl oligopeptidase family K01303 - 3.4.19.1 9.128e-206 656.0
HKD2_k127_9146127_1 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 503.0
HKD2_k127_9146127_2 alpha beta K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001343 250.0
HKD2_k127_9146127_3 Elongation factor G C-terminus K06207 GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - 0.0000000000000000000000000000000000000000000000007447 177.0
HKD2_k127_9185137_0 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001631 500.0
HKD2_k127_9185137_1 Urocanase C-terminal domain K01712 - 4.2.1.49 0.00000000000000000000000935 107.0
HKD2_k127_9185137_2 Alpha beta hydrolase - - - 0.0000000000000000002572 100.0
HKD2_k127_9228042_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.0 1464.0
HKD2_k127_9228042_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1450.0
HKD2_k127_9228042_2 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 590.0
HKD2_k127_9228042_3 PFAM ABC transporter related K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002008 424.0
HKD2_k127_9228042_4 Protein of unknown function (DUF1501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005093 291.0
HKD2_k127_9228042_5 Protein of unknown function (DUF1800) - - - 0.0000000000000000000000000000000000000000000000000000000000005347 230.0
HKD2_k127_9228042_6 - - - - 0.0000000000000000000000000000000000000000000000000002249 197.0
HKD2_k127_9228042_7 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000007189 184.0
HKD2_k127_9228042_8 transcriptional regulator - - - 0.000000000000000000000000000000000000000000002125 174.0
HKD2_k127_9228042_9 Activator of hsp90 atpase 1 family protein - - - 0.00000000001787 73.0
HKD2_k127_9233521_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 1.269e-194 647.0
HKD2_k127_9233521_1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000001768 245.0
HKD2_k127_9233521_2 PFAM sigma-70 region 2 domain protein K03088 - - 0.0000000000000000000002344 101.0
HKD2_k127_9233521_3 ABC transporter K06158 - - 0.000000000000000001659 92.0
HKD2_k127_9233521_4 Domain of unknown function (DUF4349) - - - 0.0000038 56.0
HKD2_k127_9291964_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 3.601e-314 982.0
HKD2_k127_9291964_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 1.292e-217 688.0
HKD2_k127_9291964_10 Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins K03571 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - 0.00000001153 63.0
HKD2_k127_9291964_2 PFAM penicillin-binding protein transpeptidase K05515 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006529 364.0
HKD2_k127_9291964_3 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009738 281.0
HKD2_k127_9291964_4 Transaldolase/Fructose-6-phosphate aldolase K00616 - 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000004083 254.0
HKD2_k127_9291964_5 PFAM ComEC Rec2-related protein K02238 - - 0.000000000000000000000000000000000000000000000000000000000007662 232.0
HKD2_k127_9291964_6 AI-2E family transporter - - - 0.00000000000000000000000000000000000000000000000000002288 202.0
HKD2_k127_9291964_7 Competence protein ComEA K02237 - - 0.00000000000000000000000000005382 124.0
HKD2_k127_9291964_8 - - - - 0.000000001499 64.0
HKD2_k127_9291964_9 DNA polymerase III, delta subunit K02340 - 2.7.7.7 0.0000000112 68.0
HKD2_k127_9317523_0 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007525 504.0
HKD2_k127_9317523_1 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.00000000000000000000000000000000000000000000000009994 188.0
HKD2_k127_9317523_2 peroxidase activity - - - 0.00000000000000000000000000000000000000000006845 176.0
HKD2_k127_9317523_3 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.0000000000000000000000000000000000005434 149.0
HKD2_k127_9334384_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 6.088e-239 749.0
HKD2_k127_9334384_1 PFAM peptidase S45 penicillin amidase K01434 - 3.5.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004641 527.0
HKD2_k127_9334384_2 PFAM Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007891 434.0
HKD2_k127_9334384_3 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009187 387.0
HKD2_k127_9334384_4 formate dehydrogenase, beta subunit K00124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001947 349.0
HKD2_k127_9334384_5 Polysulphide reductase, NrfD - - - 0.0000000000000000000000000000000000000000000000000000000000000000002687 241.0
HKD2_k127_9334384_6 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.0000000000000000000000000000000000001104 147.0
HKD2_k127_9334384_7 Biotin-requiring enzyme K01960 - 6.4.1.1 0.0000000000002855 80.0
HKD2_k127_9356465_0 TIGRFAM DNA polymerase III, alpha subunit K02337 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008056 512.0
HKD2_k127_9356465_1 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000002671 130.0
HKD2_k127_9360409_0 5TM C-terminal transporter carbon starvation CstA K06200 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007154,GO:0008150,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - 7.66e-222 703.0
HKD2_k127_9360409_1 Aldehyde dehydrogenase family K00294,K13821 - 1.2.1.88,1.5.5.2 1.405e-201 659.0
HKD2_k127_9360409_10 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001214 333.0
HKD2_k127_9360409_11 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009653 303.0
HKD2_k127_9360409_12 ABC transporter permease K02034 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001472 289.0
HKD2_k127_9360409_13 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004507 288.0
HKD2_k127_9360409_14 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006386 291.0
HKD2_k127_9360409_15 ABC transporter substrate-binding protein K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004834 280.0
HKD2_k127_9360409_16 SnoaL-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000002745 229.0
HKD2_k127_9360409_17 Creatinase/Prolidase N-terminal domain K01271 - 3.4.13.9 0.0000000000000000000000000000000000000000000000000000001391 209.0
HKD2_k127_9360409_18 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000002431 205.0
HKD2_k127_9360409_19 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.0000000000000000000000000000000000000000000000000013 199.0
HKD2_k127_9360409_2 Pfam Anion-transporting ATPase K01551 - 3.6.3.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004367 472.0
HKD2_k127_9360409_20 Sodium/hydrogen exchanger family K03316 - - 0.0000000000000000000000000000000000000000000008866 180.0
HKD2_k127_9360409_21 - - - - 0.000000000000000000000000000000000000000000001432 166.0
HKD2_k127_9360409_22 Iron dependent repressor, N-terminal DNA binding domain - - - 0.00000000000000000000000000000000000000007145 159.0
HKD2_k127_9360409_23 PFAM pyridoxamine 5'-phosphate oxidase-related - - - 0.00000000000000000000000000002111 134.0
HKD2_k127_9360409_24 Dinitrogenase iron-molybdenum cofactor - - - 0.0000000000000000000000000005815 116.0
HKD2_k127_9360409_25 peptidase dimerisation domain protein K01439 - 3.5.1.18 0.000000000000000000000003999 117.0
HKD2_k127_9360409_26 Transcriptional regulatory protein, C terminal K07669 - - 0.000000000000000001685 96.0
HKD2_k127_9360409_28 Carbon monoxide dehydrogenase subunit G (CoxG) K03518 - 1.2.5.3 0.00000000009555 73.0
HKD2_k127_9360409_29 - - - - 0.000000003938 64.0
HKD2_k127_9360409_3 Pfam Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001895 453.0
HKD2_k127_9360409_30 PFAM response regulator receiver K02483,K07658 - - 0.00000001514 63.0
HKD2_k127_9360409_31 Protein of unknown function (DUF2892) - - - 0.0000003018 56.0
HKD2_k127_9360409_4 Aldehyde dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008496 409.0
HKD2_k127_9360409_5 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009671 396.0
HKD2_k127_9360409_6 amidase activity K02433 - 6.3.5.6,6.3.5.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006601 370.0
HKD2_k127_9360409_7 NAD(P)-binding Rossmann-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006829 363.0
HKD2_k127_9360409_8 Belongs to the TPP enzyme family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 368.0
HKD2_k127_9360409_9 Thiamine pyrophosphate enzyme, central domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 348.0
HKD2_k127_941005_0 FMN-dependent dehydrogenase K00101,K00467 - 1.1.2.3,1.13.12.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003549 559.0
HKD2_k127_941005_1 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001227 369.0
HKD2_k127_941005_2 luxR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006029 331.0
HKD2_k127_941005_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004856 303.0
HKD2_k127_941005_4 PFAM Polysulphide reductase, NrfD K00185 - - 0.0000000000000000000000000000000001161 141.0
HKD2_k127_941005_5 Cytochrome c - - - 0.0000000000001242 78.0
HKD2_k127_9545282_0 belongs to the aldehyde dehydrogenase family K00135,K08324 GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0032787,GO:0034641,GO:0042133,GO:0042135,GO:0042402,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.16,1.2.1.20,1.2.1.24,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 608.0
HKD2_k127_9545282_1 Acyl-CoA dehydrogenase, N-terminal domain K00248,K00249,K18244 - 1.3.8.1,1.3.8.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009032 514.0
HKD2_k127_9545282_10 Thioredoxin - - - 0.000000000000000000000000000000000000000000004161 173.0
HKD2_k127_9545282_11 PFAM flavin reductase domain protein, FMN-binding K21297,K21727 - 1.5.1.36 0.00000000000000000000000000000000000000000003951 166.0
HKD2_k127_9545282_12 MaoC like domain K18290 - 4.2.1.56 0.000000000000000000000000000000000000000008363 159.0
HKD2_k127_9545282_13 quinone binding - - - 0.0000000000000000000000000006543 121.0
HKD2_k127_9545282_2 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001738 479.0
HKD2_k127_9545282_3 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000336 427.0
HKD2_k127_9545282_4 Fumarylacetoacetate (FAA) hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006519 307.0
HKD2_k127_9545282_5 Negative regulator of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000008976 250.0
HKD2_k127_9545282_6 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000001537 247.0
HKD2_k127_9545282_7 coenzyme F420-1:gamma-L-glutamate ligase activity - - - 0.00000000000000000000000000000000000000000000000000000004452 205.0
HKD2_k127_9545282_8 Beta-lactamase superfamily domain - - - 0.0000000000000000000000000000000000000000000000000001104 194.0
HKD2_k127_9545282_9 Belongs to the HpcH HpaI aldolase family K01644 - 4.1.3.34 0.0000000000000000000000000000000000000000000000005628 191.0
HKD2_k127_9547748_0 glycosidase K20885 - 2.4.1.339,2.4.1.340 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001686 293.0
HKD2_k127_9547748_1 DNA polymerase Ligase (LigD) - - - 0.00000000000000000000000000000000000000000000000000000000000000000001322 244.0
HKD2_k127_9547748_2 ATP dependent DNA ligase domain protein K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000005991 227.0
HKD2_k127_9547748_3 DNA ligase K01971 - 6.5.1.1 0.000000000000000000000000000000000000000000000000000000185 203.0
HKD2_k127_9547748_4 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000004319 184.0
HKD2_k127_9547748_5 Natural resistance-associated macrophage protein - - - 0.0000000000000000000000000000000000000127 150.0
HKD2_k127_9547748_6 Small integral membrane protein - - - 0.00000000000000000000000000002618 129.0
HKD2_k127_9547748_7 Hemerythrin HHE cation binding domain - - - 0.0000000000000000000000001515 113.0
HKD2_k127_9547748_8 - - - - 0.000000001186 70.0
HKD2_k127_9581295_0 aminopeptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002441 270.0
HKD2_k127_9581295_1 Polysaccharide deacetylase K22278 - 3.5.1.104 0.0000000000000000000000000000000000000000000000000000000000000004433 242.0
HKD2_k127_9581295_2 Conserved repeat domain - - - 0.00000000000000000000003901 115.0
HKD2_k127_9581295_3 positive regulation of growth K19687 - - 0.000000001563 71.0
HKD2_k127_9671568_0 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 1.6e-214 683.0
HKD2_k127_9671568_1 Peptidase U62 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 428.0
HKD2_k127_9671568_10 Sulfite exporter TauE/SafE K07090 - - 0.00000000000000004576 96.0
HKD2_k127_9671568_11 - - - - 0.0000000009437 70.0
HKD2_k127_9671568_12 - - - - 0.000001849 57.0
HKD2_k127_9671568_13 - - - - 0.00002617 55.0
HKD2_k127_9671568_2 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 340.0
HKD2_k127_9671568_3 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005313 327.0
HKD2_k127_9671568_4 Dehydrogenase reductase sdr K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000002728 271.0
HKD2_k127_9671568_5 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000001133 206.0
HKD2_k127_9671568_6 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000003606 199.0
HKD2_k127_9671568_7 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine K07566 GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 0.000000000000000000000000000000000000001053 155.0
HKD2_k127_9671568_8 Uncharacterised protein family UPF0047 - - - 0.000000000000000000000000000000000000122 148.0
HKD2_k127_9671568_9 PFAM Ribose galactose isomerase K01808 - 5.3.1.6 0.00000000000000000000000000000003223 131.0
HKD2_k127_9725002_0 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004474 314.0
HKD2_k127_9725002_1 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000002589 180.0
HKD2_k127_9725002_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.00000000000000000000000000000000196 142.0
HKD2_k127_9725002_3 PFAM Binding-protein-dependent transport system inner membrane component K02034 - - 0.0000000000000003796 79.0
HKD2_k127_9758880_0 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.000000000000000000000000000000000000000008406 160.0
HKD2_k127_9758880_1 PFAM cyclic nucleotide-binding K16922 - - 0.0000000000000000000000000002033 133.0
HKD2_k127_9758880_2 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000000000000009624 105.0
HKD2_k127_9758880_3 cGMP-dependent protein kinase activity K07376 GO:0000302,GO:0001558,GO:0002164,GO:0003008,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004690,GO:0004692,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007275,GO:0007525,GO:0007526,GO:0007568,GO:0007600,GO:0007606,GO:0007610,GO:0007611,GO:0007612,GO:0007631,GO:0007635,GO:0008150,GO:0008152,GO:0008286,GO:0008306,GO:0008340,GO:0008355,GO:0009605,GO:0009606,GO:0009628,GO:0009636,GO:0009719,GO:0009725,GO:0009791,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010259,GO:0010468,GO:0010469,GO:0010646,GO:0010647,GO:0010648,GO:0010752,GO:0010753,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017015,GO:0018105,GO:0018193,GO:0018209,GO:0019222,GO:0019538,GO:0022898,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030308,GO:0030431,GO:0030512,GO:0030536,GO:0030537,GO:0030545,GO:0032101,GO:0032103,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032501,GO:0032502,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0036211,GO:0040008,GO:0040011,GO:0040012,GO:0040014,GO:0040015,GO:0040017,GO:0042048,GO:0042056,GO:0042221,GO:0042330,GO:0042493,GO:0042542,GO:0043085,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043269,GO:0043271,GO:0043412,GO:0043434,GO:0043577,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045926,GO:0046620,GO:0046621,GO:0046662,GO:0046677,GO:0048018,GO:0048513,GO:0048518,GO:0048519,GO:0048520,GO:0048522,GO:0048523,GO:0048569,GO:0048580,GO:0048581,GO:0048583,GO:0048584,GO:0048585,GO:0048638,GO:0048640,GO:0048731,GO:0048856,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050795,GO:0050848,GO:0050849,GO:0050877,GO:0050890,GO:0050896,GO:0050909,GO:0050913,GO:0050918,GO:0050920,GO:0050921,GO:0051049,GO:0051051,GO:0051093,GO:0051128,GO:0051239,GO:0051240,GO:0051241,GO:0051336,GO:0051342,GO:0051343,GO:0051345,GO:0051716,GO:0060255,GO:0060259,GO:0061061,GO:0061062,GO:0061064,GO:0061065,GO:0061067,GO:0065007,GO:0065009,GO:0070482,GO:0070887,GO:0071310,GO:0071375,GO:0071417,GO:0071495,GO:0071704,GO:0090092,GO:0090101,GO:0090287,GO:0090288,GO:0097305,GO:0098772,GO:0140096,GO:1901046,GO:1901419,GO:1901421,GO:1901564,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902159,GO:1902160,GO:1902531,GO:1902532,GO:1902533,GO:1903844,GO:1903845,GO:1903998,GO:1905957,GO:1905959,GO:1990335,GO:1990834,GO:2000026,GO:2000241,GO:2000243 2.7.11.12 0.0000000000000008235 92.0
HKD2_k127_9758880_4 Domain of unknown function (DUF4395) - - - 0.00000000008281 71.0
HKD2_k127_9766735_0 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000001372 141.0
HKD2_k127_9766735_1 Peptidase family M28 - - - 0.00000000000000000000000000000002308 145.0
HKD2_k127_9766735_2 diguanylate cyclase - - - 0.00000000000008113 83.0
HKD2_k127_9766735_3 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.0007449 52.0
HKD2_k127_9769798_0 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 3.568e-265 835.0
HKD2_k127_9769798_1 PFAM aminotransferase class I and II K10907 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002967 504.0
HKD2_k127_9769798_10 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - 0.000000000000000000000000000000000000000000000000000000000000008383 229.0
HKD2_k127_9769798_11 COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III K00784 - 3.1.26.11 0.0000000000000000000000000000000000000000000000000000000000006402 222.0
HKD2_k127_9769798_12 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 0.000000000000000000000000000000000000000000000004842 181.0
HKD2_k127_9769798_13 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000009581 169.0
HKD2_k127_9769798_14 Belongs to the ALAD family K01698 - 4.2.1.24 0.00000000000000000000000000000000000000004059 164.0
HKD2_k127_9769798_15 Hydrolase of X-linked nucleoside diphosphate N terminal - - - 0.0000000000000000000000000000001449 131.0
HKD2_k127_9769798_16 Peptidase_C39 like family - - - 0.00000000000000000000000004441 121.0
HKD2_k127_9769798_17 Glycosyl transferase family 2 K00721 - 2.4.1.83 0.00000000000000000008578 105.0
HKD2_k127_9769798_18 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.00000000006695 76.0
HKD2_k127_9769798_19 PFAM TadE family protein - - - 0.0000002132 59.0
HKD2_k127_9769798_2 Involved in galactofuranosyl biosynthesis converts UDO-GlcP to UDP-GalP catalytic activity UDP- glucopyranose UDP-galactopyranose - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002985 467.0
HKD2_k127_9769798_20 TadE-like protein - - - 0.000002372 59.0
HKD2_k127_9769798_21 PFAM Cysteine-rich secretory protein family - - - 0.000005418 57.0
HKD2_k127_9769798_22 TadE-like protein - - - 0.00002046 53.0
HKD2_k127_9769798_23 Putative Flp pilus-assembly TadE/G-like - - - 0.00005949 55.0
HKD2_k127_9769798_3 UDP binding domain K02472 - 1.1.1.336 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008633 420.0
HKD2_k127_9769798_4 TIGRFAM RNA polymerase sigma-54 factor, RpoN K03092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002411 370.0
HKD2_k127_9769798_5 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002216 327.0
HKD2_k127_9769798_6 aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008391 325.0
HKD2_k127_9769798_7 WD40-like Beta Propeller Repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003011 267.0
HKD2_k127_9769798_8 Glycosyl transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000006392 244.0
HKD2_k127_9769798_9 Protein of unknown function (DUF554) K07150 - - 0.000000000000000000000000000000000000000000000000000000000000007711 224.0
HKD2_k127_9810519_0 Methylenetetrahydrofolate reductase K00297 - 1.5.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001625 286.0
HKD2_k127_9810519_1 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.000000000000000000000000000000000000000000000000000002526 211.0
HKD2_k127_9810519_2 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003871,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0030312,GO:0032259,GO:0034641,GO:0035999,GO:0036211,GO:0040007,GO:0042084,GO:0042085,GO:0042558,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0050667,GO:0051186,GO:0071704,GO:0071944,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.14 0.00000000000000000000000000000000000000000000000000009812 197.0
HKD2_k127_9810519_3 PFAM Formiminotransferase-cyclodeaminase - - - 0.000000000000000002687 93.0
HKD2_k127_9810519_4 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.0001065 51.0
HKD2_k127_9816680_0 R3H domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001253 596.0
HKD2_k127_9816680_1 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001374 296.0
HKD2_k127_9816680_2 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS K08681 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000003932 231.0
HKD2_k127_9816680_3 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 0.00000000000000000000000000000000000000000000001312 178.0
HKD2_k127_9816680_4 Cyclic-di-AMP receptor - - - 0.000000000000000000000000000000002703 132.0
HKD2_k127_9816680_5 luxR family - - - 0.0000000000006889 74.0
HKD2_k127_9880810_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 1.64e-274 880.0
HKD2_k127_9880810_1 Endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000253 143.0
HKD2_k127_9880810_2 Phosphoglycerate mutase family - - - 0.0000000000000000000000005274 112.0
HKD2_k127_9880810_3 Abortive infection protein K07052 - - 0.0000000000000001886 90.0
HKD2_k127_9880810_4 Belongs to the 5'(3')-deoxyribonucleotidase family K05967 - - 0.0000000000004399 77.0
HKD2_k127_9886992_0 modulator of DNA gyrase K03568 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001989 359.0
HKD2_k127_9886992_1 extracellular solute-binding protein, family 1 K05772 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002031 287.0
HKD2_k127_9886992_2 Putative modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000007677 231.0
HKD2_k127_9886992_3 PFAM Conserved TM helix repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000146 181.0
HKD2_k127_9886992_4 NYN domain - - - 0.000003133 59.0
HKD2_k127_9898914_0 YibE F family protein - - - 0.00000000000000000000000000000000001135 148.0
HKD2_k127_9898914_1 phosphatidylinositol metabolic process K13671 - - 0.0000000000000000000000000000000002799 151.0
HKD2_k127_9898914_2 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000002096 128.0
HKD2_k127_9898914_3 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000003739 116.0
HKD2_k127_9898914_4 PFAM Polyketide cyclase dehydrase - - - 0.0000001529 59.0
HKD2_k127_9915268_0 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03404,K03405 - 6.6.1.1 1.152e-198 632.0
HKD2_k127_9915268_1 PFAM FAD linked oxidase domain protein K00104 - 1.1.3.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001757 429.0
HKD2_k127_9915268_10 ParB-like nuclease domain - - - 0.000000000004225 72.0
HKD2_k127_9915268_2 Amidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001123 407.0
HKD2_k127_9915268_3 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000195 362.0
HKD2_k127_9915268_4 CBS domain-containing protein K03699 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 343.0
HKD2_k127_9915268_5 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03635,K21142 - 2.8.1.12 0.00000000000000000000000000000000000000000000000001013 191.0
HKD2_k127_9915268_6 PFAM FAD linked oxidase domain protein K11472 - - 0.000000000000000000000000000000000000000000000003259 193.0
HKD2_k127_9915268_7 F420-dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000005075 189.0
HKD2_k127_9915268_8 type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis - - - 0.00000000000000000000000000000000000000000003325 175.0
HKD2_k127_9915268_9 von Willebrand factor (vWF) type A domain - - - 0.0000000000000000291 85.0
HKD2_k127_9925315_0 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 2.192e-235 758.0
HKD2_k127_9925315_1 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 369.0
HKD2_k127_9925315_10 PFAM nitrogen-fixing NifU domain protein K04488 - - 0.0000005435 59.0
HKD2_k127_9925315_11 gas vesicle protein - - - 0.0002689 46.0
HKD2_k127_9925315_2 Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 K00566 - 2.8.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002686 314.0
HKD2_k127_9925315_3 phosphatidylinositol metabolic process K13671 - - 0.00000000000000000000000000000000000000000000000000000000000002971 231.0
HKD2_k127_9925315_4 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.000000000000000000000000000000000000000000000000000000001037 219.0
HKD2_k127_9925315_5 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 0.0000000000000000000000000000000000000000000000000003266 194.0
HKD2_k127_9925315_6 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.000000000000000000000000000000000000000000000002409 186.0
HKD2_k127_9925315_7 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000000000000000000000000000000000001442 147.0
HKD2_k127_9925315_8 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - 0.00000000000000000165 89.0
HKD2_k127_9925315_9 Baseplate J-like protein K01218 - 3.2.1.78 0.000000000001941 80.0