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Overview

ID MAG01807
Name HKD2_bin.60
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Pseudomonadota
Class Gammaproteobacteria
Order Burkholderiales
Family Burkholderiaceae
Genus JALORV01
Species
Assembly information
Completeness (%) 94.31
Contamination (%) 3.66
GC content (%) 67.0
N50 (bp) 27,016
Genome size (bp) 3,743,704

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes3481

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10037532_0 Belongs to the malic enzymes family K00029 - 1.1.1.40 1.982e-294 918.0
HKD2_k127_10037532_1 - - - - 0.00000000000002089 76.0
HKD2_k127_10096020_0 Bacterial NAD-glutamate dehydrogenase K15371 - 1.4.1.2 0.0 1702.0
HKD2_k127_10096020_1 Heavy metal transport detoxification protein K17686 - 3.6.3.54 7.427e-256 814.0
HKD2_k127_10096020_10 Glycine zipper 2TM domain - - - 0.000000000000000000000000000000000000000000000000000002822 198.0
HKD2_k127_10096020_11 Domain of unknown function (DUF1993) - - - 0.00000000000000000000000000000000000000000000000000001359 198.0
HKD2_k127_10096020_12 Domain of unknown function DUF302 - - - 0.00000000000000000000000000000000000000000000002757 173.0
HKD2_k127_10096020_13 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000013 168.0
HKD2_k127_10096020_14 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.000000000000000000000000000000000000008679 153.0
HKD2_k127_10096020_15 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000002976 139.0
HKD2_k127_10096020_16 Domain of unknown function (DUF1857) - - - 0.0000000000000000000000000000003254 136.0
HKD2_k127_10096020_17 - - - - 0.000000000000000000000000000001559 129.0
HKD2_k127_10096020_18 Cupin 2, conserved barrel domain protein - - - 0.0000000000000000000000000004147 126.0
HKD2_k127_10096020_19 - - - - 0.00000000000000000536 91.0
HKD2_k127_10096020_2 O-methyltransferase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008377 623.0
HKD2_k127_10096020_20 - - - - 0.000005329 58.0
HKD2_k127_10096020_3 PrpF protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003788 466.0
HKD2_k127_10096020_4 GIY-YIG type nucleases (URI domain) K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001536 407.0
HKD2_k127_10096020_5 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) K06920 - 6.3.4.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003052 349.0
HKD2_k127_10096020_6 coenzyme F420-1:gamma-L-glutamate ligase activity K19285,K19286 - 1.5.1.38,1.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 348.0
HKD2_k127_10096020_7 Hydrolases of the alpha beta superfamily K06889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 312.0
HKD2_k127_10096020_8 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000006929 252.0
HKD2_k127_10096020_9 Nuclear protein SET K07117 - - 0.00000000000000000000000000000000000000000000000000000000001904 212.0
HKD2_k127_10098676_0 Sulfatase K01130 - 3.1.6.1 0.0 1512.0
HKD2_k127_10098676_1 Belongs to the GcvT family K00315,K19191 - 1.5.3.19,1.5.8.4 0.0 1155.0
HKD2_k127_10098676_10 AMP-binding enzyme C-terminal domain K01911 - 6.2.1.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004633 477.0
HKD2_k127_10098676_11 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003222 448.0
HKD2_k127_10098676_12 Protein of unknown function (DUF1800) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002435 440.0
HKD2_k127_10098676_13 PFAM conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 376.0
HKD2_k127_10098676_14 Twin-arginine translocation pathway signal sequence - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001237 383.0
HKD2_k127_10098676_15 Peptidase C26 K01658,K07010 - 4.1.3.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 346.0
HKD2_k127_10098676_16 Belongs to the MenA family. Type 1 subfamily K02548 - 2.5.1.74 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006898 334.0
HKD2_k127_10098676_17 Predicted periplasmic protein (DUF2092) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005852 287.0
HKD2_k127_10098676_18 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000007063 263.0
HKD2_k127_10098676_19 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001947 267.0
HKD2_k127_10098676_2 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 3.664e-314 981.0
HKD2_k127_10098676_20 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000001229 258.0
HKD2_k127_10098676_21 Protein of unknown function (DUF502) - - - 0.0000000000000000000000000000000000000000000000000000000000000000002229 236.0
HKD2_k127_10098676_22 - - - - 0.0000000000000000000000000000000000000000000000000000000000000001902 230.0
HKD2_k127_10098676_23 COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase K07305 - 1.8.4.12 0.0000000000000000000000000000000000000000000000000000000000003468 215.0
HKD2_k127_10098676_24 Outer membrane lipoprotein K06077 - - 0.00000000000000000000000000000000000000000000000000000000004123 209.0
HKD2_k127_10098676_25 long-chain fatty acid transport protein - - - 0.00000000000000000000000000000000000000000000000000007289 197.0
HKD2_k127_10098676_26 Sel1-like repeats. K07126 - - 0.000000000000000000000000000000000000314 151.0
HKD2_k127_10098676_27 - - - - 0.00000000000000000000000000000007639 127.0
HKD2_k127_10098676_28 Regulatory protein, FmdB family - - - 0.00000000000000000000000000000483 123.0
HKD2_k127_10098676_3 regulation of DNA-templated transcription, elongation - - - 1.641e-292 921.0
HKD2_k127_10098676_30 - - - - 0.00000000000000000000000003634 112.0
HKD2_k127_10098676_31 - - - - 0.0000000000000002709 90.0
HKD2_k127_10098676_4 Glutamine synthetase, catalytic domain K01915 - 6.3.1.2 7.568e-238 742.0
HKD2_k127_10098676_5 Aldehyde dehydrogenase family - - - 1.389e-209 662.0
HKD2_k127_10098676_6 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 561.0
HKD2_k127_10098676_7 Iron-containing alcohol dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000513 558.0
HKD2_k127_10098676_8 Alanine dehydrogenase/PNT, N-terminal domain K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008747 552.0
HKD2_k127_10098676_9 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661,K07536 - 4.1.3.36 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006065 522.0
HKD2_k127_10103650_0 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K02021,K11085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 566.0
HKD2_k127_10103650_1 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 313.0
HKD2_k127_10103650_2 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003996 334.0
HKD2_k127_10103650_3 PFAM glycosyl transferase family 9 K02849 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008545 292.0
HKD2_k127_10103650_4 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001283 277.0
HKD2_k127_10103650_5 heptosyltransferase K02843 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005304 265.0
HKD2_k127_10103650_6 PFAM Glycosyl transferase, family 25 K07270 - - 0.0000000000000000000000000000000000000000000000000000000000000000007758 245.0
HKD2_k127_10103650_7 PFAM O-Antigen - - - 0.0000000000000000000000000000000000000000000000000004042 204.0
HKD2_k127_10103650_8 Belongs to the UPF0312 family - - - 0.0000000000000000000000000000000000000000000000002081 183.0
HKD2_k127_10122597_0 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme K02302,K02303 - 1.3.1.76,2.1.1.107,4.99.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004175 536.0
HKD2_k127_10122597_1 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001069 344.0
HKD2_k127_10198899_0 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 511.0
HKD2_k127_10198899_1 Belongs to the DapA family K01714 - 4.3.3.7 0.000000000000006982 76.0
HKD2_k127_10209780_0 Belongs to the sulfate adenylyltransferase family K00958 - 2.7.7.4 8.464e-221 691.0
HKD2_k127_10209780_1 2Fe-2S iron-sulfur cluster binding domain K00523 - 1.17.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002812 498.0
HKD2_k127_10209780_2 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 413.0
HKD2_k127_10209780_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001346 340.0
HKD2_k127_10209780_4 reductase beta subunit K00395 - 1.8.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000633 290.0
HKD2_k127_10209780_5 PFAM UspA domain protein K07090 - - 0.00000000000000000000000000000000000000001674 163.0
HKD2_k127_10209780_6 - - - - 0.0000000000000000000000000000002018 134.0
HKD2_k127_1075882_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.0 1000.0
HKD2_k127_1075882_1 Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs K08300 - 3.1.26.12 1.453e-285 904.0
HKD2_k127_1075882_10 Transcriptional regulator K21703 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 416.0
HKD2_k127_1075882_11 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003144 413.0
HKD2_k127_1075882_12 malonyl CoA-acyl carrier protein transacylase K00645,K15355 - 2.3.1.39 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 398.0
HKD2_k127_1075882_13 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008445 398.0
HKD2_k127_1075882_14 Responsible for synthesis of pseudouridine from uracil K06179 - 5.4.99.24 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 384.0
HKD2_k127_1075882_15 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008332 373.0
HKD2_k127_1075882_16 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004481 377.0
HKD2_k127_1075882_17 reductase K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 343.0
HKD2_k127_1075882_18 TatD related DNase K03424 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 334.0
HKD2_k127_1075882_19 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005659 332.0
HKD2_k127_1075882_2 deoxyribodipyrimidine photolyase-related protein K06876 - - 1.687e-236 741.0
HKD2_k127_1075882_20 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002328 315.0
HKD2_k127_1075882_21 Belongs to the GcvT family K06980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000008741 278.0
HKD2_k127_1075882_22 molybdopterin K03750 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001437 274.0
HKD2_k127_1075882_23 Uroporphyrin-iii c tetrapyrrole (Corrin porphyrin) methyltransferase K07056 - 2.1.1.198 0.0000000000000000000000000000000000000000000000000000000000000000000000008688 255.0
HKD2_k127_1075882_24 HAD-superfamily hydrolase, subfamily IA, variant 1 K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000000000000000000000000000006121 250.0
HKD2_k127_1075882_25 negative regulator of sigma E activity K03598 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000137 256.0
HKD2_k127_1075882_26 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis K00943 - 2.7.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000008355 251.0
HKD2_k127_1075882_27 DNA polymerase III, delta' K02341 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000001815 247.0
HKD2_k127_1075882_28 Transport and Golgi organisation 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000007951 237.0
HKD2_k127_1075882_29 Maf-like protein K06287 - - 0.0000000000000000000000000000000000000000000000000000000001428 209.0
HKD2_k127_1075882_3 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00646,K09458 GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0016740,GO:0016746,GO:0016747,GO:0033817 2.3.1.179 2.862e-201 633.0
HKD2_k127_1075882_30 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.00000000000000000000000000000000000000000000000000000000127 220.0
HKD2_k127_1075882_31 PilZ domain K02676 - - 0.000000000000000000000000000000000000000000003829 168.0
HKD2_k127_1075882_32 Rieske [2Fe-2S] domain - - - 0.00000000000000000000000000000000000003495 153.0
HKD2_k127_1075882_33 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000001366 154.0
HKD2_k127_1075882_34 Carrier of the growing fatty acid chain in fatty acid biosynthesis K02078 - - 0.00000000000000000000000000000000004432 136.0
HKD2_k127_1075882_35 Involved in DNA repair and RecF pathway recombination K03584 - - 0.0000000000000000000000000000005324 124.0
HKD2_k127_1075882_36 Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity K03782 - 1.11.1.21 0.0000000000000000000000000000006708 121.0
HKD2_k127_1075882_37 Uncharacterized ACR, COG1399 K07040 - - 0.0000000000000000000000000000008112 131.0
HKD2_k127_1075882_38 Belongs to the bacterial ribosomal protein bL32 family K02911 - - 0.000000000000000000000000002168 112.0
HKD2_k127_1075882_39 Domain of unknown function (DUF4845) - - - 0.00000000000000000000000003285 112.0
HKD2_k127_1075882_4 belongs to the aldehyde dehydrogenase family K00128,K00154 - 1.2.1.3,1.2.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 591.0
HKD2_k127_1075882_40 PFAM Anti sigma-E protein RseA family protein K03597 - - 0.000000005781 66.0
HKD2_k127_1075882_41 Domain of unknown function (DUF4936) - - - 0.0000009266 59.0
HKD2_k127_1075882_5 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001354 552.0
HKD2_k127_1075882_6 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 510.0
HKD2_k127_1075882_7 Na+ dependent nucleoside transporter C-terminus K03317 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 443.0
HKD2_k127_1075882_8 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 420.0
HKD2_k127_1075882_9 Na+-dependent bicarbonate transporter superfamily K07086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 415.0
HKD2_k127_1221499_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 5.381e-257 810.0
HKD2_k127_1221499_1 Belongs to the short-chain dehydrogenases reductases (SDR) family K00019 - 1.1.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009681 395.0
HKD2_k127_1221499_2 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 357.0
HKD2_k127_1221499_3 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 306.0
HKD2_k127_1221499_4 Belongs to the MtfA family K09933 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003221 286.0
HKD2_k127_1221499_5 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.000000000000000000000000000000000000000000000000000000000297 205.0
HKD2_k127_1221499_6 COG0655 Multimeric flavodoxin WrbA - - - 0.000000000000000000000000000000000000000000000000000000000414 207.0
HKD2_k127_1221499_7 PFAM 20S proteasome, A and B subunits K07395 - - 0.000000000000000000000000000000000000000000000000002336 185.0
HKD2_k127_1280499_0 Extracellular solute-binding protein, family 5 middle family protein 22 - - - 9.479e-292 923.0
HKD2_k127_1280499_1 Oligopeptide/dipeptide transporter, C-terminal region K02031,K02032 - - 1.757e-251 796.0
HKD2_k127_1280499_10 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005616 411.0
HKD2_k127_1280499_11 PFAM MotA TolQ ExbB proton channel K03562 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001948 299.0
HKD2_k127_1280499_12 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.00000000000000000000000000000000000000000000000000000000000005502 224.0
HKD2_k127_1280499_13 Belongs to the ompA family K03640 - - 0.000000000000000000000000000000000000000000000000006016 186.0
HKD2_k127_1280499_14 thioesterase K07107 - - 0.000000000000000000000000000000000000009401 151.0
HKD2_k127_1280499_15 Biopolymer transport protein ExbD/TolR K03560 - - 0.0000000000000000000000000000000003743 136.0
HKD2_k127_1280499_16 COG0810 Periplasmic protein TonB, links inner and outer membranes K03646 - - 0.000000000000000000001673 105.0
HKD2_k127_1280499_17 Cytochrome c K17223 - - 0.0000000003163 63.0
HKD2_k127_1280499_2 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001568 584.0
HKD2_k127_1280499_3 TonB dependent receptor K02014 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007072 566.0
HKD2_k127_1280499_4 Involved in the tonB-independent uptake of proteins K03641 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 530.0
HKD2_k127_1280499_5 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 520.0
HKD2_k127_1280499_6 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003114 527.0
HKD2_k127_1280499_7 FAD binding domain K05712 - 1.14.13.127 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002695 507.0
HKD2_k127_1280499_8 Sulphur transport K07112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009418 439.0
HKD2_k127_1280499_9 ubiE/COQ5 methyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000403 439.0
HKD2_k127_1302675_0 AcrB/AcrD/AcrF family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004055 583.0
HKD2_k127_1302675_1 Molybdopterin oxidoreductase Fe4S4 domain K02567 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007013 379.0
HKD2_k127_1302675_2 4Fe-4S binding domain K02574 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 333.0
HKD2_k127_1302675_3 4Fe-4S binding domain K02573 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002411 246.0
HKD2_k127_1302675_4 GYD domain - - - 0.0000000000000000000000000000000000342 139.0
HKD2_k127_1302675_5 Cytochrome c-type biogenesis protein K02200 - - 0.0000000000000000000000000000000001469 144.0
HKD2_k127_1302675_6 Protein of unknown function (DUF2892) - - - 0.000000000000000000000000000000001964 132.0
HKD2_k127_1302675_7 Metal-sensitive transcriptional repressor - - - 0.00000000000000002915 85.0
HKD2_k127_1302675_8 Electron transfer subunit of the periplasmic nitrate reductase complex NapAB K02568 - - 0.000000003656 69.0
HKD2_k127_1318092_0 Peptidase family M13 K07386 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006152 443.0
HKD2_k127_1318092_1 Methyltransferase domain - - - 0.000000000000000000000000000000000000002479 150.0
HKD2_k127_1318690_0 Alkyl hydroperoxide reductase K03387 - - 1.387e-264 824.0
HKD2_k127_1318690_1 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 456.0
HKD2_k127_1318690_10 LemA family K03744 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001364 278.0
HKD2_k127_1318690_11 major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002866 295.0
HKD2_k127_1318690_12 COG1179 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 K22132 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001199 278.0
HKD2_k127_1318690_13 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine K07304 - 1.8.4.11 0.0000000000000000000000000000000000000000000000000000000000000000000000004577 251.0
HKD2_k127_1318690_14 helix_turn_helix, Lux Regulon - - - 0.00000000000000000000000000000000000000000000000000000000000000000001992 239.0
HKD2_k127_1318690_15 Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides K07232 - - 0.00000000000000000000000000000000000000000000000000000000000001594 224.0
HKD2_k127_1318690_16 of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000005374 216.0
HKD2_k127_1318690_17 TPM domain - - - 0.000000000000000000000000000000000000000000000000006523 185.0
HKD2_k127_1318690_18 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000000002128 183.0
HKD2_k127_1318690_19 TPM domain K06872 - - 0.00000000000000000000000000000000000000000000000009585 192.0
HKD2_k127_1318690_2 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03386 - 1.11.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 346.0
HKD2_k127_1318690_20 Redoxin - - - 0.00000000000000000000000000000000000000000000003218 175.0
HKD2_k127_1318690_21 Flavin reductase like domain - - - 0.00000000000000000000000000000000000000000000003964 173.0
HKD2_k127_1318690_22 Rieske 2Fe-2S K00499 - 1.14.15.7 0.00000000000000000000000000000000000000002966 154.0
HKD2_k127_1318690_23 Polysaccharide deacetylase K01452 - 3.5.1.41 0.00000000000000000000000000006067 128.0
HKD2_k127_1318690_24 Domain of unknown function (DUF4266) - - - 0.0000000000000000002293 91.0
HKD2_k127_1318690_25 Hemerythrin HHE cation binding domain K07216 - - 0.000000000000000002988 90.0
HKD2_k127_1318690_26 Hemerythrin HHE cation binding domain K07216 - - 0.00000005952 59.0
HKD2_k127_1318690_3 Universal stress protein family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000354 349.0
HKD2_k127_1318690_4 Protein of unknown function DUF72 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001317 334.0
HKD2_k127_1318690_5 Protein of unknown function (DUF533) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001006 331.0
HKD2_k127_1318690_6 Protein of unknown function (DUF3570) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001671 323.0
HKD2_k127_1318690_7 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 320.0
HKD2_k127_1318690_8 Histidine kinase-like ATPases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002242 323.0
HKD2_k127_1318690_9 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008993 288.0
HKD2_k127_1322998_0 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 4.041e-248 773.0
HKD2_k127_1322998_1 COG0457 FOG TPR repeat - - - 4.363e-238 751.0
HKD2_k127_1322998_10 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006466 351.0
HKD2_k127_1322998_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001613 344.0
HKD2_k127_1322998_12 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006597 279.0
HKD2_k127_1322998_13 Phosphoserine phosphatase K01079 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000497 260.0
HKD2_k127_1322998_14 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.0000000000000000000000000000000000000000000000000000000000000000004937 248.0
HKD2_k127_1322998_15 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.000000000000000000000000000000000000000000000000000000000000000101 231.0
HKD2_k127_1322998_16 PspC domain - - - 0.00000000000000000001169 106.0
HKD2_k127_1322998_17 Helix-hairpin-helix motif - - - 0.000000000000000002941 96.0
HKD2_k127_1322998_18 Protein of unknown function (DUF465) - - - 0.00000000000000006739 81.0
HKD2_k127_1322998_2 Poly(R)-hydroxyalkanoic acid synthase, class I K03821 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 1.935e-214 683.0
HKD2_k127_1322998_3 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 5.75e-196 619.0
HKD2_k127_1322998_4 helicase K03722 - 3.6.4.12 1.276e-195 632.0
HKD2_k127_1322998_5 Belongs to the thiolase family K00626 - 2.3.1.9 7.913e-194 610.0
HKD2_k127_1322998_6 Dehydrogenase E1 component K00164 - 1.2.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000162 553.0
HKD2_k127_1322998_7 PFAM AFG1-family ATPase K06916 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 518.0
HKD2_k127_1322998_8 Belongs to the short-chain dehydrogenases reductases (SDR) family K00023 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 1.1.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005464 441.0
HKD2_k127_1322998_9 Dimerisation domain of Zinc Transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002792 384.0
HKD2_k127_1327544_0 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004748 609.0
HKD2_k127_1327544_1 MgsA AAA+ ATPase C terminal K07478 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000604 596.0
HKD2_k127_1327544_2 PFAM cell divisionFtsK SpoIIIE K03466 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 338.0
HKD2_k127_1327544_3 cation diffusion facilitator family transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006158 336.0
HKD2_k127_1327544_4 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) K03634 - - 0.00000000000000000000000000000000000000000000000000000000000000008029 231.0
HKD2_k127_1327544_5 FKBP-type peptidyl-prolyl cis-trans isomerase K03772,K03773 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000005555 196.0
HKD2_k127_1336532_0 Atp-dependent helicase K03578 - 3.6.4.13 0.0 1642.0
HKD2_k127_1336532_1 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate K01007 - 2.7.9.2 0.0 1221.0
HKD2_k127_1336532_10 Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 K14441 - 2.8.4.4 8.654e-219 686.0
HKD2_k127_1336532_11 Catalyzes the synthesis of GMP from XMP K01951 - 6.3.5.2 1.944e-217 684.0
HKD2_k127_1336532_12 ABC-type Fe3 transport system, periplasmic component - - - 2.259e-201 637.0
HKD2_k127_1336532_13 Belongs to the thiolase family K00626 - 2.3.1.9 1.847e-198 625.0
HKD2_k127_1336532_14 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00382,K00627 - 1.8.1.4,2.3.1.12 4.779e-198 632.0
HKD2_k127_1336532_15 Belongs to the acetyltransferase family. ArgA subfamily K14682 - 2.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004855 596.0
HKD2_k127_1336532_16 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls K01439 - 3.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 544.0
HKD2_k127_1336532_17 PFAM Aminotransferase class I and II K14267 - 2.6.1.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 537.0
HKD2_k127_1336532_18 Aminoglycoside phosphotransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008143 516.0
HKD2_k127_1336532_19 Putative nucleotidyltransferase substrate binding domain K07182 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005099 527.0
HKD2_k127_1336532_2 Required for chromosome condensation and partitioning K03529 - - 0.0 1138.0
HKD2_k127_1336532_20 C-terminal region of band_7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001008 461.0
HKD2_k127_1336532_21 MCM2/3/5 family K03544 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 462.0
HKD2_k127_1336532_22 Metallopeptidase family M24 K01265 GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0140096,GO:1901564 3.4.11.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002959 458.0
HKD2_k127_1336532_23 Type II/IV secretion system protein K02670 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 456.0
HKD2_k127_1336532_24 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02010 - 3.6.3.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005141 473.0
HKD2_k127_1336532_25 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 436.0
HKD2_k127_1336532_26 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001765 439.0
HKD2_k127_1336532_27 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008037 427.0
HKD2_k127_1336532_28 Putative nucleotide-binding of sugar-metabolising enzyme K21948 - 2.7.1.217 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001415 436.0
HKD2_k127_1336532_29 40-residue YVTN family beta-propeller repeat protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001286 423.0
HKD2_k127_1336532_3 Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen K00990 - 2.7.7.59 0.0 1018.0
HKD2_k127_1336532_30 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006556 406.0
HKD2_k127_1336532_31 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 - 1.1.1.267 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002668 410.0
HKD2_k127_1336532_32 X-Pro dipeptidyl-peptidase (S15 family) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001977 402.0
HKD2_k127_1336532_33 Belongs to the universal ribosomal protein uS2 family K02967 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 393.0
HKD2_k127_1336532_34 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation K09773 - 2.7.11.33,2.7.4.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001229 391.0
HKD2_k127_1336532_35 Fatty acid hydroxylase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 396.0
HKD2_k127_1336532_36 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 391.0
HKD2_k127_1336532_37 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00748 - 2.4.1.182 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000207 401.0
HKD2_k127_1336532_38 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue K07320 - 2.1.1.298 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 369.0
HKD2_k127_1336532_39 CoA-transferase family III K01796 - 5.1.99.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001864 376.0
HKD2_k127_1336532_4 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 - 6.5.1.2 1.412e-291 909.0
HKD2_k127_1336532_40 Asp/Glu/Hydantoin racemase K01779 - 5.1.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005553 351.0
HKD2_k127_1336532_41 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003575 334.0
HKD2_k127_1336532_42 Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K00677 - 2.3.1.129 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 336.0
HKD2_k127_1336532_43 Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage K00772 - 2.4.2.28 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001271 327.0
HKD2_k127_1336532_44 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001593 316.0
HKD2_k127_1336532_45 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005152 308.0
HKD2_k127_1336532_46 Protein of unknown function (DUF1326) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005695 306.0
HKD2_k127_1336532_47 xylanase chitin deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 308.0
HKD2_k127_1336532_48 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003616 305.0
HKD2_k127_1336532_49 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009089 284.0
HKD2_k127_1336532_5 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 3.011e-287 902.0
HKD2_k127_1336532_50 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001264 282.0
HKD2_k127_1336532_51 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate K01807 - 5.3.1.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001267 284.0
HKD2_k127_1336532_52 Polyhydroxyalkanoate synthesis repressor PhaR - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001961 272.0
HKD2_k127_1336532_53 PFAM 20S proteasome, A and B subunits K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000009411 269.0
HKD2_k127_1336532_54 Class II Aldolase and Adducin N-terminal domain K22130 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009056,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0019321,GO:0019323,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0071704,GO:1901575 4.1.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000002428 247.0
HKD2_k127_1336532_55 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03470 - 3.1.26.4 0.0000000000000000000000000000000000000000000000000000000000000000001196 242.0
HKD2_k127_1336532_56 Phosphoglycerate mutase - - - 0.00000000000000000000000000000000000000000000000000000000000000008912 243.0
HKD2_k127_1336532_57 the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA K03664 - - 0.0000000000000000000000000000000000000000000000000000000000000002345 223.0
HKD2_k127_1336532_58 COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000006851 226.0
HKD2_k127_1336532_59 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) K09457 - 1.7.1.13 0.0000000000000000000000000000000000000000000000000000000000007951 215.0
HKD2_k127_1336532_6 pyridine nucleotide-disulphide oxidoreductase dimerisation region K00382 - 1.8.1.4 1.368e-282 878.0
HKD2_k127_1336532_60 Belongs to the skp family K06142 - - 0.000000000000000000000000000000000000000000000000000000005326 203.0
HKD2_k127_1336532_61 SpoU rRNA Methylase family K03437 - - 0.00000000000000000000000000000000000000000000000000000006731 205.0
HKD2_k127_1336532_62 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.000000000000000000000000000000000000000000000000000001799 199.0
HKD2_k127_1336532_63 PFAM blue (type 1) copper domain protein - - - 0.0000000000000000000000000000000000000000000000000006611 199.0
HKD2_k127_1336532_64 Oligoketide cyclase lipid transport protein - - - 0.000000000000000000000000000000000000000000000004435 177.0
HKD2_k127_1336532_65 Belongs to the CDS family K00981 - 2.7.7.41 0.00000000000000000000000000000000000000000000005639 180.0
HKD2_k127_1336532_66 Exonuclease K02342 - 2.7.7.7 0.0000000000000000000000000000000000000000000309 169.0
HKD2_k127_1336532_67 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000000000000000000000000000000000006385 171.0
HKD2_k127_1336532_68 Protein of unknown function (DUF2459) - - - 0.0000000000000000000000000000000000000001353 167.0
HKD2_k127_1336532_69 Asp Glu hydantoin racemase - - - 0.0000000000000000000000000000000000000892 149.0
HKD2_k127_1336532_7 ABC-type Fe3 transport system permease component K02011 - - 3.112e-258 807.0
HKD2_k127_1336532_70 Bacterial protein of unknown function (DUF882) - - - 0.00000000000000000000000000000000007 142.0
HKD2_k127_1336532_71 Glutathione S-transferase, N-terminal domain K11208 - - 0.0000000000000000000000000000000002087 142.0
HKD2_k127_1336532_72 Membrane protein implicated in regulation of membrane protease activity - - - 0.00000000000000000000000000000001613 131.0
HKD2_k127_1336532_73 Proteasome subunit - - - 0.00000000000000000000000002805 109.0
HKD2_k127_1336532_74 Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins - - - 0.00000000000000000000003067 112.0
HKD2_k127_1336532_75 - - - - 0.0000000000000000000003048 104.0
HKD2_k127_1336532_76 Domain of unknown function (DUF4124) - - - 0.0000000000000000000003536 105.0
HKD2_k127_1336532_77 Belongs to the UPF0125 (RnfH) family K09801 - - 0.000000000000000009738 87.0
HKD2_k127_1336532_78 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000003347 91.0
HKD2_k127_1336532_79 - - - - 0.000000000000003404 80.0
HKD2_k127_1336532_8 ABC transporter C-terminal domain K06158 - - 9.638e-253 796.0
HKD2_k127_1336532_9 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 6.927e-244 762.0
HKD2_k127_1367483_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370,K17050 - 1.7.5.1 0.0 2356.0
HKD2_k127_1367483_1 nitrite transporter K02575 - - 4.865e-309 952.0
HKD2_k127_1367483_2 Respiratory nitrate reductase beta C-terminal K00371 - 1.7.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001433 407.0
HKD2_k127_1367483_3 GAF domain K07673 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005359 402.0
HKD2_k127_1367483_4 Bacterial regulatory proteins, luxR family K07684 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002198 256.0
HKD2_k127_1367483_5 Cytochrome P450 - - - 0.00000000007056 69.0
HKD2_k127_1369093_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.0 1069.0
HKD2_k127_1369093_1 Fe-S oxidoreductase K21834 - - 9.245e-283 873.0
HKD2_k127_1369093_2 Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source K02224 - 6.3.5.11,6.3.5.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 534.0
HKD2_k127_1369093_3 Sulphur transport K07112 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004716 453.0
HKD2_k127_1369093_4 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 442.0
HKD2_k127_1369093_5 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein K00184 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000526 352.0
HKD2_k127_1369093_6 Nitrate reductase gamma subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007101 331.0
HKD2_k127_1369093_7 - - - - 0.000000000000000000000002265 110.0
HKD2_k127_1369093_8 Belongs to the HesB IscA family K13628 - - 0.00000000000001662 87.0
HKD2_k127_1369093_9 Belongs to the N-Me-Phe pilin family K02650 - - 0.000001963 51.0
HKD2_k127_1376211_0 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner K01873 - 6.1.1.9 0.0 1384.0
HKD2_k127_1376211_1 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain K01872 - 6.1.1.7 0.0 1298.0
HKD2_k127_1376211_10 BNR repeat-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 378.0
HKD2_k127_1376211_11 Bacterial regulatory proteins, crp family K01420 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 357.0
HKD2_k127_1376211_12 cytochrome C oxidase K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000253 330.0
HKD2_k127_1376211_13 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002028 280.0
HKD2_k127_1376211_14 SAD/SRA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002127 265.0
HKD2_k127_1376211_15 PFAM NUDIX hydrolase K03426 - 3.6.1.22 0.0000000000000000000000000000000000000000000000000000000000000009521 222.0
HKD2_k127_1376211_16 Protein of unknown function (DUF1294) - - - 0.0000000000000000000000000000000000000000000000000000000009436 207.0
HKD2_k127_1376211_17 Protein of unknown function (DUF2726) - - - 0.00000000000000000000000000000000000000000000000007928 183.0
HKD2_k127_1376211_18 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000005917 174.0
HKD2_k127_1376211_19 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.000000000000000000000000000000000000000000003522 173.0
HKD2_k127_1376211_2 glutaminyl-tRNA synthetase K01886 - 6.1.1.18 3.045e-274 861.0
HKD2_k127_1376211_20 - - - - 0.0000000000000000000000000000000000000000001005 166.0
HKD2_k127_1376211_21 PFAM GCN5-related N-acetyltransferase K03825 - - 0.000000000000000000000000000000000000000378 156.0
HKD2_k127_1376211_23 Major facilitator Superfamily - - - 0.000000000000000000000000000000000001312 154.0
HKD2_k127_1376211_24 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000002609 142.0
HKD2_k127_1376211_25 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000001182 147.0
HKD2_k127_1376211_26 Belongs to the sulfur carrier protein TusA family K04085 - - 0.00000000000000000000000000000001105 128.0
HKD2_k127_1376211_27 - - - - 0.00000000000000000000000000006117 132.0
HKD2_k127_1376211_28 - - - - 0.000000000000000000000000003705 114.0
HKD2_k127_1376211_29 FixH family K09926 - - 0.00000000000000000000002016 110.0
HKD2_k127_1376211_3 Belongs to the heme-copper respiratory oxidase family K00404 - 1.9.3.1 1.19e-271 840.0
HKD2_k127_1376211_30 cell adhesion involved in biofilm formation - - - 0.000000000000000000005768 104.0
HKD2_k127_1376211_31 Cbb3-type cytochrome oxidase K00407 - - 0.0000000000001418 72.0
HKD2_k127_1376211_32 protein, possibly involved in nitrogen fixation - - - 0.00009764 46.0
HKD2_k127_1376211_4 C-terminal region of peptidase_M24 K01262 - 3.4.11.9 1.316e-253 798.0
HKD2_k127_1376211_5 Protein of unknown function (DUF1254) - - - 5.076e-225 707.0
HKD2_k127_1376211_6 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002103 595.0
HKD2_k127_1376211_7 Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 581.0
HKD2_k127_1376211_8 Heavy-metal-associated domain K01533 - 3.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003147 521.0
HKD2_k127_1376211_9 C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex K00406 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 397.0
HKD2_k127_1428282_0 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 0.0 1030.0
HKD2_k127_1428282_1 PFAM AMP-dependent synthetase and ligase K20034 - 6.2.1.44 1.131e-271 845.0
HKD2_k127_1428282_10 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000001758 246.0
HKD2_k127_1428282_11 Belongs to the BolA IbaG family K05527 - - 0.0000000000000000000000000000236 119.0
HKD2_k127_1428282_12 Outer membrane protein (OmpH-like) K06142 - - 0.0000000000000000000000001201 117.0
HKD2_k127_1428282_2 Belongs to the UPF0061 (SELO) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005169 576.0
HKD2_k127_1428282_3 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 521.0
HKD2_k127_1428282_4 amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004125 511.0
HKD2_k127_1428282_5 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 412.0
HKD2_k127_1428282_6 ABC transporter K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 361.0
HKD2_k127_1428282_7 KR domain K07124 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 302.0
HKD2_k127_1428282_8 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 294.0
HKD2_k127_1428282_9 probably involved in intracellular septation K06190 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005634 252.0
HKD2_k127_1436723_0 Berberine and berberine like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001785 508.0
HKD2_k127_1436723_1 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000007544 248.0
HKD2_k127_143979_0 COG0457 FOG TPR repeat - - - 4.296e-225 722.0
HKD2_k127_143979_1 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002749 528.0
HKD2_k127_143979_10 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000001208 276.0
HKD2_k127_143979_11 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001216 244.0
HKD2_k127_143979_12 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000003951 170.0
HKD2_k127_143979_13 helix_turn_helix, Lux Regulon - - - 0.00000000000005071 79.0
HKD2_k127_143979_2 Major facilitator superfamily K03446,K18926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001313 489.0
HKD2_k127_143979_3 von Willebrand factor, type A K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001307 402.0
HKD2_k127_143979_4 Protein of unknown function (DUF3300) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000818 377.0
HKD2_k127_143979_5 Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity K06188 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 364.0
HKD2_k127_143979_6 Signal transduction histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001611 376.0
HKD2_k127_143979_7 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 378.0
HKD2_k127_143979_8 peptidase S1 and S6, chymotrypsin Hap - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001819 319.0
HKD2_k127_143979_9 Protein of unknown function (DUF2950) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 301.0
HKD2_k127_1456143_0 oxidoreductase K04090 - 1.2.7.8 0.0 1638.0
HKD2_k127_1456143_1 Peptidase family M3 K01284 - 3.4.15.5 6.659e-252 796.0
HKD2_k127_1456143_10 General secretion pathway protein F K02455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 434.0
HKD2_k127_1456143_11 PFAM aromatic amino acid K00500 - 1.14.16.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002606 419.0
HKD2_k127_1456143_12 PFAM peptidase S1 and S6, chymotrypsin Hap - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003682 374.0
HKD2_k127_1456143_13 LytTr DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004698 342.0
HKD2_k127_1456143_14 Protein of unknown function (DUF1211) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001404 310.0
HKD2_k127_1456143_15 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 310.0
HKD2_k127_1456143_16 Di-haem cytochrome c peroxidase K00428 - 1.11.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001786 288.0
HKD2_k127_1456143_17 general secretion pathway protein G K02456 - - 0.00000000000000000000000000000000000000000000000000000000000000002697 228.0
HKD2_k127_1456143_18 helix_turn_helix ASNC type K03719 - - 0.00000000000000000000000000000000000000000000000000000000000005743 216.0
HKD2_k127_1456143_19 Type II secretion system (T2SS), protein K K02460 - - 0.0000000000000000000000000000000000000000000000000000000001471 224.0
HKD2_k127_1456143_2 type II secretion system protein E K02454 - - 8.153e-207 666.0
HKD2_k127_1456143_20 membrane - - - 0.000000000000000000000000000000000000000000000004752 176.0
HKD2_k127_1456143_21 acetyltransferase - - - 0.00000000000000000000000000000000000000000004055 171.0
HKD2_k127_1456143_22 General Secretory Pathway K02463 - - 0.0000000000000000000000000000000000000000005035 167.0
HKD2_k127_1456143_23 Lipocalin-like domain - - - 0.000000000000000000000000005975 116.0
HKD2_k127_1456143_24 PFAM GCN5-related N-acetyltransferase - - - 0.0000000000000000000000003732 112.0
HKD2_k127_1456143_25 - - - - 0.0000000000000000000000004412 113.0
HKD2_k127_1456143_26 EF-hand domain - - - 0.0000000000000000000000009286 117.0
HKD2_k127_1456143_27 General secretion pathway protein L K02461 - - 0.000000000000000000000008507 115.0
HKD2_k127_1456143_28 general secretion pathway protein K02457 - - 0.00000000000000000000003602 107.0
HKD2_k127_1456143_29 General secretion pathway protein I K02458 - - 0.00000000000000000001395 100.0
HKD2_k127_1456143_3 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal K00457 - 1.13.11.27 1.945e-203 638.0
HKD2_k127_1456143_30 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.00000000000000000004866 90.0
HKD2_k127_1456143_31 General secretion pathway K02462 - - 0.000000000000000000062 104.0
HKD2_k127_1456143_32 Protein of unknown function (DUF3108) - - - 0.000000000000000001487 99.0
HKD2_k127_1456143_33 general secretion pathway protein K02459 - - 0.000000000000000002144 94.0
HKD2_k127_1456143_34 PFAM major facilitator superfamily MFS_1 K19577 - - 0.000000000000008132 77.0
HKD2_k127_1456143_35 general secretion pathway protein K02452 - - 0.0000001915 60.0
HKD2_k127_1456143_4 general secretion pathway protein D K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004468 629.0
HKD2_k127_1456143_5 fumarylacetoacetate (FAA) hydrolase K16171 - 3.7.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002212 532.0
HKD2_k127_1456143_6 Belongs to the arginase family K01476,K01480,K12255,K18459 - 3.5.3.1,3.5.3.11,3.5.3.17,3.5.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 520.0
HKD2_k127_1456143_7 peptidase K01389,K01415,K07386 - 3.4.24.11,3.4.24.71 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008615 503.0
HKD2_k127_1456143_8 PFAM Aminotransferase class I and II K00812 - 2.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004198 488.0
HKD2_k127_1456143_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 443.0
HKD2_k127_1486294_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.0 1116.0
HKD2_k127_1486294_1 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 2.04e-270 839.0
HKD2_k127_1486294_10 Preprotein translocase SecG subunit K03075 - - 0.000000000000000000000000001468 117.0
HKD2_k127_1486294_11 Catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive K01652 - 2.2.1.6 0.0000000000000000000001327 97.0
HKD2_k127_1486294_2 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate K00053 - 1.1.1.86 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003032 579.0
HKD2_k127_1486294_3 NADPH quinone oxidoreductase K00344 - 1.6.5.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008731 477.0
HKD2_k127_1486294_4 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 388.0
HKD2_k127_1486294_5 Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) K01613 - 4.1.1.65 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000664 316.0
HKD2_k127_1486294_6 Acetolactate synthase, small subunit K01653 GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003418 290.0
HKD2_k127_1486294_7 Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) K01803 - 5.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000001148 263.0
HKD2_k127_1486294_8 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome K02956 - - 0.00000000000000000000000000000000000003861 144.0
HKD2_k127_1486294_9 Protein of unknown function (DUF541) - - - 0.00000000000000000000000000000004172 136.0
HKD2_k127_1497524_0 PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding K07303 - 1.3.99.16 8.911e-259 820.0
HKD2_k127_1497524_1 alcohol dehydrogenase K19745 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001378 429.0
HKD2_k127_1497524_2 Belongs to the enoyl-CoA hydratase isomerase family K01692,K01715,K07534 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001239 429.0
HKD2_k127_1497524_3 amino acid K03294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002211 413.0
HKD2_k127_1497524_4 Flavin containing amine oxidoreductase K00231,K14266 - 1.14.19.9,1.3.3.15,1.3.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000372 351.0
HKD2_k127_1497524_5 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009187 342.0
HKD2_k127_1497524_6 Histone methylation protein DOT1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000005137 263.0
HKD2_k127_1497524_7 2Fe-2S -binding domain protein K07302 - 1.3.99.16 0.00000000000000000000000000000000000000000000000000000000001225 210.0
HKD2_k127_1497524_8 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.00000000000000000000000000000000000000007328 158.0
HKD2_k127_1529282_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.0 1347.0
HKD2_k127_1529282_1 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 0.0 1283.0
HKD2_k127_1529282_10 Proton-conducting membrane transporter K12141 - - 5.455e-251 782.0
HKD2_k127_1529282_11 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.12 1.319e-250 784.0
HKD2_k127_1529282_12 FAD-dependent pyridine nucleotide-disulfide oxidoreductase K17218 - 1.8.5.4 8.641e-228 711.0
HKD2_k127_1529282_13 Patatin-like phospholipase - - - 1.242e-219 699.0
HKD2_k127_1529282_14 AMP-binding enzyme C-terminal domain K18661 - - 4.247e-218 694.0
HKD2_k127_1529282_15 PFAM extracellular solute-binding protein family 1 K05813 - - 5.642e-218 685.0
HKD2_k127_1529282_16 Acyl-CoA dehydrogenase, C-terminal domain K09456 - - 9.175e-216 683.0
HKD2_k127_1529282_17 Respiratory-chain NADH dehydrogenase, 49 Kd subunit - - - 2.012e-194 642.0
HKD2_k127_1529282_18 PFAM Adenylyl cyclase class-3 4 guanylyl cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 640.0
HKD2_k127_1529282_19 Pilus retraction K02669,K12203 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005182 590.0
HKD2_k127_1529282_2 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.0 1281.0
HKD2_k127_1529282_20 Adenylate cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 601.0
HKD2_k127_1529282_21 Type II/IV secretion system protein K02670 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001877 582.0
HKD2_k127_1529282_22 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate K00147 GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001416 575.0
HKD2_k127_1529282_23 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 550.0
HKD2_k127_1529282_24 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000267 533.0
HKD2_k127_1529282_25 Belongs to the ABC transporter superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001637 524.0
HKD2_k127_1529282_26 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 512.0
HKD2_k127_1529282_27 ATPases associated with a variety of cellular activities K05816,K10111,K10112 - 3.6.3.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002277 489.0
HKD2_k127_1529282_28 Binding-protein-dependent transport system inner membrane component - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005972 467.0
HKD2_k127_1529282_29 Binding-protein-dependent transport system inner membrane component K02025,K05814,K10118,K17242,K17245 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006243 453.0
HKD2_k127_1529282_3 Methylmalonyl-CoA mutase large subunit K01847 - 5.4.99.2 0.0 1069.0
HKD2_k127_1529282_30 NADH dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002287 475.0
HKD2_k127_1529282_31 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004009 437.0
HKD2_k127_1529282_32 XdhC and CoxI family K07402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 433.0
HKD2_k127_1529282_33 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves K05896 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 428.0
HKD2_k127_1529282_34 THUMP domain K07444 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009479 400.0
HKD2_k127_1529282_35 Belongs to the pseudomonas-type ThrB family K02204 - 2.7.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006122 396.0
HKD2_k127_1529282_36 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002623 407.0
HKD2_k127_1529282_37 TIGRFAM 40-residue YVTN family beta-propeller repeat protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 373.0
HKD2_k127_1529282_38 Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate K00215 - 1.17.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004741 361.0
HKD2_k127_1529282_39 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179 - 2.5.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000693 351.0
HKD2_k127_1529282_4 helicase K03657 - 3.6.4.12 0.0 1027.0
HKD2_k127_1529282_40 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003015 348.0
HKD2_k127_1529282_41 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 348.0
HKD2_k127_1529282_42 Di-haem cytochrome c peroxidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 345.0
HKD2_k127_1529282_43 CO dehydrogenase flavoprotein C-terminal domain K03519 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002772 336.0
HKD2_k127_1529282_44 receptor K02014,K16092 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 345.0
HKD2_k127_1529282_45 Belongs to the peptidase S8 family K14645 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004382 346.0
HKD2_k127_1529282_46 ABC-type dipeptide transport system periplasmic component K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000492 321.0
HKD2_k127_1529282_47 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 328.0
HKD2_k127_1529282_48 Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001026 308.0
HKD2_k127_1529282_49 hydrogenase 4 membrane K12140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007487 319.0
HKD2_k127_1529282_5 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 - 6.1.1.10 4.696e-312 970.0
HKD2_k127_1529282_50 response regulator K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000964 294.0
HKD2_k127_1529282_51 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001377 276.0
HKD2_k127_1529282_52 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001875 272.0
HKD2_k127_1529282_53 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline K00286 - 1.5.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001892 273.0
HKD2_k127_1529282_54 Biopolymer transport K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002519 275.0
HKD2_k127_1529282_55 Periplasmic binding protein K02016,K06858 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000473 273.0
HKD2_k127_1529282_56 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000009389 270.0
HKD2_k127_1529282_57 FecCD transport family K02015 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001142 268.0
HKD2_k127_1529282_58 Belongs to the peptidase S8 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001998 278.0
HKD2_k127_1529282_59 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001138 253.0
HKD2_k127_1529282_6 Proton-conducting membrane transporter - - - 2.068e-308 957.0
HKD2_k127_1529282_60 Glutathione peroxidase K00432 - 1.11.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000005976 248.0
HKD2_k127_1529282_61 COG0671 Membrane-associated phospholipid phosphatase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005091 254.0
HKD2_k127_1529282_62 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000002969 242.0
HKD2_k127_1529282_63 EVE domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000008919 237.0
HKD2_k127_1529282_64 carbon monoxide dehydrogenase K03518 - 1.2.5.3 0.00000000000000000000000000000000000000000000000000000000000000000001152 235.0
HKD2_k127_1529282_65 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex K01548 - 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000001574 244.0
HKD2_k127_1529282_66 Sulfate permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000006516 246.0
HKD2_k127_1529282_67 Belongs to the Fur family K03711 - - 0.000000000000000000000000000000000000000000000000000000000000001422 222.0
HKD2_k127_1529282_68 2-hydroxychromene-2-carboxylate isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000003125 222.0
HKD2_k127_1529282_69 protein conserved in bacteria K04750 - - 0.0000000000000000000000000000000000000000000000000000000001397 207.0
HKD2_k127_1529282_7 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 4.716e-302 940.0
HKD2_k127_1529282_70 SMART cyclic nucleotide-binding K10914 - - 0.000000000000000000000000000000000000000000000000000000004326 218.0
HKD2_k127_1529282_71 ATPases associated with a variety of cellular activities K02013 - 3.6.3.34 0.0000000000000000000000000000000000000000000009898 177.0
HKD2_k127_1529282_72 Prokaryotic cytochrome b561 K12262 - - 0.000000000000000000000000000000000000000000004014 171.0
HKD2_k127_1529282_73 PFAM Ankyrin K06867 - - 0.00000000000000000000000000000000000000000004227 168.0
HKD2_k127_1529282_74 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000000000000000000000000000000000001649 151.0
HKD2_k127_1529282_75 Biopolymer transport protein, ExbD K03559 - - 0.00000000000000000000000000000000000002443 150.0
HKD2_k127_1529282_76 GrpB protein - - - 0.0000000000000000000000000000000000003131 147.0
HKD2_k127_1529282_77 - - - - 0.000000000000000000000000000000000002016 148.0
HKD2_k127_1529282_78 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 - - 0.000000000000000000000000000000063 145.0
HKD2_k127_1529282_79 SmpA / OmlA family - - - 0.0000000000000000000000000003684 120.0
HKD2_k127_1529282_8 PQQ enzyme repeat - - - 5.728e-302 932.0
HKD2_k127_1529282_80 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K06186 - - 0.0000000000000000000000001314 114.0
HKD2_k127_1529282_81 COG0790 FOG TPR repeat, SEL1 subfamily K07126 - - 0.0000000000000000000000004997 113.0
HKD2_k127_1529282_82 Cell division protein ZapA K09888 - - 0.000000000000000000002428 100.0
HKD2_k127_1529282_83 Protein of unknown function (DUF4019) - - - 0.000000000000000000003165 102.0
HKD2_k127_1529282_84 PFAM CopG domain protein DNA-binding domain protein - - - 0.0000000000000000006181 90.0
HKD2_k127_1529282_85 - - - - 0.00000000000000001736 89.0
HKD2_k127_1529282_86 Domain of unknown function (DUF1330) - - - 0.00000000000000007963 83.0
HKD2_k127_1529282_87 Protein of unknown function (DUF3460) - - - 0.000000000000002138 80.0
HKD2_k127_1529282_88 Cytochrome c - - - 0.0000000002202 69.0
HKD2_k127_1529282_89 serine threonine protein kinase K03587,K08884,K12132 - 2.7.11.1,3.4.16.4 0.00000002205 63.0
HKD2_k127_1529282_9 Histidine kinase K07646 - 2.7.13.3 2.528e-267 852.0
HKD2_k127_1529282_90 - - - - 0.000001907 53.0
HKD2_k127_1538137_0 transcriptional regulator K07506 - - 0.000000000000000000000000000000000000000000002636 170.0
HKD2_k127_1538137_1 MTH538 TIR-like domain (DUF1863) - - - 0.00000000000000009356 86.0
HKD2_k127_1601930_0 Belongs to the class-II aminoacyl-tRNA synthetase family K04567 - 6.1.1.6 5.274e-230 721.0
HKD2_k127_1601930_1 Tartrate dehydrogenase K07246 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.83,1.1.1.93,4.1.1.73 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007849 603.0
HKD2_k127_1601930_10 NUDIX domain - - - 0.000000000000000000000000000000000000000000001167 177.0
HKD2_k127_1601930_11 5'-nucleotidase, C-terminal domain K01081,K11751 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006213,GO:0006259,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007155,GO:0007159,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009164,GO:0009166,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019362,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0022610,GO:0031974,GO:0031981,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042578,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046135,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:0072524,GO:0072527,GO:0072529,GO:0090304,GO:0098609,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5,3.6.1.45 0.000000000000000000000000000000000000000000003583 168.0
HKD2_k127_1601930_12 Phasin protein - - - 0.0000000000000000000000000000000000000000702 160.0
HKD2_k127_1601930_13 thiolester hydrolase activity K17362 - - 0.0000000000000000000000000000001067 128.0
HKD2_k127_1601930_14 Acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000007012 121.0
HKD2_k127_1601930_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002481 556.0
HKD2_k127_1601930_3 COG2230 Cyclopropane fatty acid synthase and related methyltransferases K00574 - 2.1.1.79 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001623 421.0
HKD2_k127_1601930_4 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005631 370.0
HKD2_k127_1601930_5 Nitroreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000146 370.0
HKD2_k127_1601930_6 Protein of unknown function (DUF2863) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005338 310.0
HKD2_k127_1601930_7 Drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 293.0
HKD2_k127_1601930_8 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000009322 282.0
HKD2_k127_1601930_9 PFAM thioesterase superfamily protein K07107 - - 0.00000000000000000000000000000000000000000000000000000000000000004449 226.0
HKD2_k127_1618683_0 Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway K08967 GO:0000096,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0010309,GO:0016491,GO:0016701,GO:0016702,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0051213,GO:0055114,GO:0071704,GO:1901564,GO:1901605 1.13.11.53,1.13.11.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000003261 268.0
HKD2_k127_1618683_1 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) K08964 - 4.2.1.109 0.000000000000000000000000000000000000000000000000000000000000000000001129 244.0
HKD2_k127_1618683_2 Transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors K12973 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009279,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016409,GO:0016416,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044462,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.251 0.000000000000000000000000000000000000000000000000000000000000000000007089 249.0
HKD2_k127_1618683_3 Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene) K09880 - 3.1.3.77 0.00000000000000000000000000000000000000000000000000000000004127 218.0
HKD2_k127_1618683_4 - - - - 0.000000006416 65.0
HKD2_k127_1618683_5 NADPH-dependent FMN reductase K19784 - - 0.0000004471 51.0
HKD2_k127_1656284_0 PFAM FAD binding domain, FAD linked oxidases, C-terminal domain K00102 - 1.1.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007735 599.0
HKD2_k127_1656284_1 UPF0761 membrane protein K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000006048 302.0
HKD2_k127_1656284_2 Belongs to the WrbA family K03809 - 1.6.5.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003552 270.0
HKD2_k127_1656284_3 - - - - 0.000000000000000000000000000000000000000001489 171.0
HKD2_k127_1656284_4 Lysine exporter protein (LYSE YGGA) - - - 0.00000000000000000000000000000000002063 138.0
HKD2_k127_1656284_5 HlyD membrane-fusion protein of T1SS K02022,K11003 - - 0.00000000000000000000000000000002906 134.0
HKD2_k127_1656284_6 membrane - - - 0.0000000000000000000000023 106.0
HKD2_k127_1661783_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696,K06001 - 4.2.1.20 2.557e-272 841.0
HKD2_k127_1661783_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000007487 289.0
HKD2_k127_1661783_2 Haemolysin-III related K11068 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002012 263.0
HKD2_k127_1661783_3 Spermidine synthase tetramerisation domain K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000004576 203.0
HKD2_k127_1661783_4 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611,K07057 - 2.5.1.128,4.1.1.50 0.000000000000000000000000000000003709 133.0
HKD2_k127_1661783_5 protein involved in exopolysaccharide biosynthesis - - - 0.000000001313 60.0
HKD2_k127_1683555_0 ABC transporter K06147,K06148 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005324 407.0
HKD2_k127_1683555_1 Protein involved in cellulose biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 296.0
HKD2_k127_1683555_2 ATP-grasp - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000636 265.0
HKD2_k127_1683555_3 Belongs to the TPP enzyme family K01652 - 2.2.1.6 0.000000000000000000000000004976 122.0
HKD2_k127_1782232_0 histidine kinase A domain protein - - - 0.0 1303.0
HKD2_k127_1782232_1 DNA polymerase III K02342 - 2.7.7.7 8.318e-282 883.0
HKD2_k127_1782232_10 Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000738 335.0
HKD2_k127_1782232_11 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008994 309.0
HKD2_k127_1782232_12 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides K03118 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005816 307.0
HKD2_k127_1782232_13 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 - 2.5.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005626 279.0
HKD2_k127_1782232_14 Cytochrome C1 K00413 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001209 285.0
HKD2_k127_1782232_15 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00411 - 1.10.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000008636 266.0
HKD2_k127_1782232_16 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 - 2.1.1.297 0.00000000000000000000000000000000000000000000000000000000000000000001287 243.0
HKD2_k127_1782232_17 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP K01496,K11755 - 3.5.4.19,3.6.1.31 0.00000000000000000000000000000000000000000000000000000001705 203.0
HKD2_k127_1782232_18 Psort location Extracellular, score K07126 - - 0.0000000000000000000000000000000000000000000000000008576 201.0
HKD2_k127_1782232_19 Scavenger mRNA decapping enzyme C-term binding K02503 - - 0.0000000000000000000000000000000000000000000000001204 179.0
HKD2_k127_1782232_2 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis K00412 - - 3.719e-216 679.0
HKD2_k127_1782232_20 Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell K03282 - - 0.00000000000000000000000000000000000000000000000378 178.0
HKD2_k127_1782232_21 Response regulator receiver domain - - - 0.000000000000000000000000000000000000000000000004268 187.0
HKD2_k127_1782232_22 Stringent starvation protein B K03600 - - 0.00000000000000000000000000000000000000000000004026 174.0
HKD2_k127_1782232_23 Belongs to the glutaredoxin family. Monothiol subfamily K07390 - - 0.000000000000000000000000000000000000000000001195 173.0
HKD2_k127_1782232_24 Phosphoribosyl-ATP K01523 - 3.6.1.31 0.00000000000000000000000000000000000002424 148.0
HKD2_k127_1782232_25 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation K03117 - - 0.00000000000000000000000000000000000004662 148.0
HKD2_k127_1782232_26 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system K03116 - - 0.00000000000000000000004123 100.0
HKD2_k127_1782232_27 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000002236 92.0
HKD2_k127_1782232_3 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA K02835 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002503 529.0
HKD2_k127_1782232_4 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001148 524.0
HKD2_k127_1782232_5 signal-transduction protein containing cAMP-binding and CBS domains K07182 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002836 531.0
HKD2_k127_1782232_6 Belongs to the peptidase S1C family K04691,K04772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009284 430.0
HKD2_k127_1782232_7 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase K01814 - 5.3.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008767 394.0
HKD2_k127_1782232_8 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004027 395.0
HKD2_k127_1782232_9 Glutathione S-transferase K03599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 370.0
HKD2_k127_1827483_0 Transcriptional regulator K03556 - - 4.789e-243 779.0
HKD2_k127_1827483_1 Belongs to the thiolase family - - - 1.641e-209 656.0
HKD2_k127_1827483_2 PFAM AMP-dependent synthetase and ligase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 599.0
HKD2_k127_1827483_3 Nitronate monooxygenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003915 430.0
HKD2_k127_1827483_4 Nitronate monooxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000002063 240.0
HKD2_k127_1871854_0 nitrite transmembrane transporter activity - - - 1.563e-270 861.0
HKD2_k127_1871854_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 3.251e-241 778.0
HKD2_k127_1871854_10 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000489 443.0
HKD2_k127_1871854_11 COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004613 442.0
HKD2_k127_1871854_12 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003636 445.0
HKD2_k127_1871854_13 Prolyl oligopeptidase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002062 430.0
HKD2_k127_1871854_14 Nitrate reductase K00374 - 1.7.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001171 374.0
HKD2_k127_1871854_15 Reversible hydration of carbon dioxide K01673 GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 366.0
HKD2_k127_1871854_16 transcriptional regulatory protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004158 367.0
HKD2_k127_1871854_17 META domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 351.0
HKD2_k127_1871854_18 ATP ADP translocase K03301 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006561 353.0
HKD2_k127_1871854_19 Virulence factor BrkB K07058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 333.0
HKD2_k127_1871854_2 Bacterial protein of unknown function (DUF853) K06915 - - 1.01e-236 741.0
HKD2_k127_1871854_20 Nitrate reductase delta subunit K00373 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003771 319.0
HKD2_k127_1871854_21 PPIC-type PPIASE domain K03769 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004781 312.0
HKD2_k127_1871854_22 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001222 293.0
HKD2_k127_1871854_23 Beta-lactamase enzyme family K17836 - 3.5.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000004815 254.0
HKD2_k127_1871854_24 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000009054 251.0
HKD2_k127_1871854_25 Maf-like protein K06287 - - 0.00000000000000000000000000000000000000000000000000000000000000007215 229.0
HKD2_k127_1871854_26 NnrS protein K07234 - - 0.0000000000000000000000000000000000000000000000000000000000000002699 239.0
HKD2_k127_1871854_27 PFAM alpha beta hydrolase fold - - - 0.00000000000000000000000000000000000000000000000000000003521 216.0
HKD2_k127_1871854_28 Prokaryotic cytochrome b561 K12262 - - 0.000000000000000000000000000000000000000000000000000000118 199.0
HKD2_k127_1871854_29 alpha-galactosidase K07407 - 3.2.1.22 0.000000000000000000000000000000000000000000000000000002601 203.0
HKD2_k127_1871854_3 ribonuclease, Rne Rng family K08301 - - 2.937e-226 710.0
HKD2_k127_1871854_30 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.00000000000000000000000000000000000000000000000000001929 193.0
HKD2_k127_1871854_31 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA K00783 - 2.1.1.177 0.000000000000000000000000000000000000000000000001559 179.0
HKD2_k127_1871854_32 - - - - 0.00000000000000000000000000000000000000000000001592 183.0
HKD2_k127_1871854_33 Belongs to the UPF0312 family - - - 0.000000000000000000000000000000000000000000009671 168.0
HKD2_k127_1871854_34 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.00000000000000000000000000000000000000004617 164.0
HKD2_k127_1871854_36 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969,K01488 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.5.4.4 0.000000000000000000000000000000001702 139.0
HKD2_k127_1871854_37 Hemerythrin HHE cation binding domain - - - 0.000000000000000000000000000000004013 135.0
HKD2_k127_1871854_38 PEP-CTERM motif - - - 0.0000000000000000000000000000008648 131.0
HKD2_k127_1871854_39 - - - - 0.00000000000000000002003 100.0
HKD2_k127_1871854_4 Belongs to the GARS family K01945 - 6.3.4.13 1.3e-202 640.0
HKD2_k127_1871854_40 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.000000000000000000184 103.0
HKD2_k127_1871854_41 - - - - 0.00000000000000006511 84.0
HKD2_k127_1871854_43 Transglycosylase associated protein - - - 0.0000000000000309 81.0
HKD2_k127_1871854_5 Respiratory nitrate reductase beta C-terminal K00371,K17051 - 1.7.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003161 557.0
HKD2_k127_1871854_6 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 529.0
HKD2_k127_1871854_7 Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX K00228 GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 489.0
HKD2_k127_1871854_8 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002561 462.0
HKD2_k127_1871854_9 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 446.0
HKD2_k127_1878724_0 Transposase (IS116 IS110 IS902 family) - - - 0.0000000000000000000000000000000000000000000000000000001788 210.0
HKD2_k127_1888218_0 Circularly permuted ATP-grasp type 2 - - - 3.295e-246 768.0
HKD2_k127_1888218_1 DHH family K07462 - - 1.88e-219 695.0
HKD2_k127_1888218_10 TatD related DNase K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 293.0
HKD2_k127_1888218_11 protein conserved in bacteria K09928 - - 0.0000000000000000000000000000000000000000000000000001208 191.0
HKD2_k127_1888218_12 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000168 177.0
HKD2_k127_1888218_13 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000002777 186.0
HKD2_k127_1888218_14 protein conserved in bacteria - - - 0.00000000000000000000002915 112.0
HKD2_k127_1888218_2 DNA internalization-related competence protein ComEC Rec2 K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 623.0
HKD2_k127_1888218_3 lipoprotein releasing system, transmembrane protein, LolC E family K09808 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003305 553.0
HKD2_k127_1888218_4 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 563.0
HKD2_k127_1888218_5 A predicted alpha-helical domain with a conserved ER motif. - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005689 454.0
HKD2_k127_1888218_6 PFAM 20S proteasome, A and B subunits K07395 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004283 363.0
HKD2_k127_1888218_7 transglutaminase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001654 303.0
HKD2_k127_1888218_8 transglutaminase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002958 301.0
HKD2_k127_1888218_9 Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 286.0
HKD2_k127_1918810_0 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 353.0
HKD2_k127_1918810_1 glutathione s-transferase K00799 - 2.5.1.18 0.000000000000000001033 87.0
HKD2_k127_1923665_0 C-terminal region of aryl-sulfatase - - - 0.0 1034.0
HKD2_k127_1923665_1 haloacid dehalogenase-like hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006138 509.0
HKD2_k127_1923665_2 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000005572 153.0
HKD2_k127_1923665_3 Radical SAM superfamily K06871 - - 0.0000000000000000000000000006621 115.0
HKD2_k127_1926696_0 Rieske-like [2Fe-2S] domain - - - 5.182e-234 733.0
HKD2_k127_1926696_1 COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component K11959 - - 1.634e-220 692.0
HKD2_k127_1926696_10 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000004616 153.0
HKD2_k127_1926696_11 ATPase family associated with various cellular activities (AAA) - - - 0.000000000001075 76.0
HKD2_k127_1926696_12 DMT(Drug metabolite transporter) superfamily permease - - - 0.0000000008566 63.0
HKD2_k127_1926696_13 PFAM AMP-dependent synthetase and ligase K01907 - 6.2.1.16 0.0002496 43.0
HKD2_k127_1926696_2 TIGRFAM chromate transporter, chromate ion transporter (CHR) family K07240 - - 1.618e-199 631.0
HKD2_k127_1926696_3 Belongs to the binding-protein-dependent transport system permease family K11960 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 572.0
HKD2_k127_1926696_4 Belongs to the binding-protein-dependent transport system permease family K11961 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 514.0
HKD2_k127_1926696_5 ABC1 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003994 399.0
HKD2_k127_1926696_6 Branched-chain amino acid ATP-binding cassette transporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006143 386.0
HKD2_k127_1926696_7 ABC transporter, ATP-binding protein K01996,K11963 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007957 315.0
HKD2_k127_1926696_8 Chromate resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000019 281.0
HKD2_k127_1926696_9 Chromate resistance exported protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000164 266.0
HKD2_k127_1993453_0 Protein of unknown function (DUF1697) - - - 0.0000000000000000000000000000000000000000000000000000001629 205.0
HKD2_k127_1993453_2 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000003117 105.0
HKD2_k127_1993453_3 Domain of unknown function (DUF4345) - - - 0.00000000000000000002962 96.0
HKD2_k127_1993453_4 - - - - 0.000000000000002371 86.0
HKD2_k127_2055547_0 NADH flavin oxidoreductase NADH oxidase K00219 - 1.3.1.34 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003936 521.0
HKD2_k127_2055547_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001679 518.0
HKD2_k127_2055547_10 CAAX protease self-immunity K07052 - - 0.0004271 50.0
HKD2_k127_2055547_2 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate K11752 - 1.1.1.193,3.5.4.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001261 466.0
HKD2_k127_2055547_3 Mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007438 459.0
HKD2_k127_2055547_4 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 415.0
HKD2_k127_2055547_5 Riboflavin synthase K00793 - 2.5.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001423 269.0
HKD2_k127_2055547_6 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000009959 250.0
HKD2_k127_2055547_7 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000000007974 222.0
HKD2_k127_2055547_8 Hsp20/alpha crystallin family - - - 0.00000000000000000000000004479 113.0
HKD2_k127_2055547_9 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.000000000000000000000003525 108.0
HKD2_k127_2082582_0 Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 397.0
HKD2_k127_2082582_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003833 374.0
HKD2_k127_2082582_2 Endonuclease/Exonuclease/phosphatase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 353.0
HKD2_k127_2082582_3 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005596 339.0
HKD2_k127_2082582_4 phenylacetate-CoA ligase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000004495 227.0
HKD2_k127_2082582_5 PFAM NUDIX hydrolase K08310 - 3.6.1.67 0.000000000000000000000000000000000000000000000000000000001057 203.0
HKD2_k127_2082582_6 Catalyzes the sodium-dependent transport of glutamate K03312 - - 0.0000000000000000000000000006175 123.0
HKD2_k127_2099913_0 permease K03303 - - 0.0 1017.0
HKD2_k127_2099913_1 Highly conserved protein containing a thioredoxin domain K06888 - - 3.452e-226 720.0
HKD2_k127_2099913_2 Histidine kinase K07646 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000007196 267.0
HKD2_k127_2099913_3 response regulator K07667 - - 0.000000000000000000000000000000000000000000000000000000000000000000005222 244.0
HKD2_k127_2099913_4 PFAM Adenylate and Guanylate cyclase catalytic domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000003291 244.0
HKD2_k127_2099913_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000002796 225.0
HKD2_k127_2099913_6 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000000000000000000000000009783 208.0
HKD2_k127_2099913_7 Protein of unknown function (DUF1059) - - - 0.000000000000000000000002193 109.0
HKD2_k127_2192330_0 Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control K00970 - 2.7.7.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000262 555.0
HKD2_k127_2192330_1 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006959 532.0
HKD2_k127_2192330_2 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) K00791 - 2.5.1.75 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 348.0
HKD2_k127_2192330_3 COG0477 Permeases of the major facilitator superfamily K07552 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004181 266.0
HKD2_k127_2192330_4 HAD-superfamily hydrolase, subfamily IB, PSPase-like - - - 0.0000000000000000000000000000000000000000000000000000000001616 213.0
HKD2_k127_2192330_5 Bacterial dnaA protein K10763 - - 0.00000000000000000000000000000000000000000000000001033 189.0
HKD2_k127_2192330_6 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.000000000000000000000000000000000000004139 153.0
HKD2_k127_2192330_7 - - - - 0.00000000008673 70.0
HKD2_k127_2284221_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1399.0
HKD2_k127_2284221_1 Belongs to the ClpA ClpB family K03694 - - 0.0 1267.0
HKD2_k127_2284221_10 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 4.79e-226 714.0
HKD2_k127_2284221_11 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003517 579.0
HKD2_k127_2284221_12 SpoVR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 561.0
HKD2_k127_2284221_13 fatty acid desaturase K00507 - 1.14.19.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000634 524.0
HKD2_k127_2284221_14 acetylornithine aminotransferase K00821 - 2.6.1.11,2.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008668 517.0
HKD2_k127_2284221_15 HI0933-like protein K07007 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 509.0
HKD2_k127_2284221_16 Pfam:Nol1_Nop2_Fmu K03500 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0031974,GO:0031981,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0070013,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:1901360 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008765 511.0
HKD2_k127_2284221_17 Sulfide dehydrogenase K05301,K17218 - 1.8.2.1,1.8.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002157 494.0
HKD2_k127_2284221_18 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline K00611 GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007863 484.0
HKD2_k127_2284221_19 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis K03527 - 1.17.7.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 482.0
HKD2_k127_2284221_2 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.0 1019.0
HKD2_k127_2284221_20 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 481.0
HKD2_k127_2284221_21 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 463.0
HKD2_k127_2284221_22 Belongs to the ribF family K11753 - 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008219 407.0
HKD2_k127_2284221_23 TIGRFAM Tyrosine recombinase XerD K04763 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006985 394.0
HKD2_k127_2284221_24 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03601 - 3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 395.0
HKD2_k127_2284221_25 Belongs to the UPF0229 family K09786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007586 393.0
HKD2_k127_2284221_26 Cell wall formation K00075 - 1.3.1.98 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001621 378.0
HKD2_k127_2284221_27 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K03601,K04564 GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004383 363.0
HKD2_k127_2284221_28 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003061 363.0
HKD2_k127_2284221_29 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000641 361.0
HKD2_k127_2284221_3 Orn/Lys/Arg decarboxylase, C-terminal domain K01583 - 4.1.1.19 3.5e-322 999.0
HKD2_k127_2284221_30 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008851 359.0
HKD2_k127_2284221_31 mechanosensitive ion channel - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001601 357.0
HKD2_k127_2284221_32 Belongs to the FPP GGPP synthase family K00795 - 2.5.1.1,2.5.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001873 342.0
HKD2_k127_2284221_33 COG0412 Dienelactone hydrolase K01061 - 3.1.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002843 334.0
HKD2_k127_2284221_34 Rhodanese Homology Domain K01011 - 2.8.1.1,2.8.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004368 333.0
HKD2_k127_2284221_35 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002036 316.0
HKD2_k127_2284221_36 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001551 302.0
HKD2_k127_2284221_37 Divalent heavy-metal cations transporter K16267 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001031 289.0
HKD2_k127_2284221_38 Belongs to the UPF0758 family K03630 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000341 284.0
HKD2_k127_2284221_39 Redoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003694 278.0
HKD2_k127_2284221_4 Malonate decarboxylase, alpha subunit, transporter K01026 - 2.8.3.1 3.042e-310 962.0
HKD2_k127_2284221_40 This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA K01520 - 3.6.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000004844 263.0
HKD2_k127_2284221_41 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000001547 253.0
HKD2_k127_2284221_42 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.000000000000000000000000000000000000000000000000000000000000000000000006045 246.0
HKD2_k127_2284221_43 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate K11175 - 2.1.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000001649 244.0
HKD2_k127_2284221_44 EamA-like transporter family K15270 - - 0.00000000000000000000000000000000000000000000000000000000000000000003698 242.0
HKD2_k127_2284221_45 Belongs to the UPF0234 family K09767 - - 0.0000000000000000000000000000000000000000000000000000000000000001372 225.0
HKD2_k127_2284221_46 Glutamine amidotransferase class-I - - - 0.0000000000000000000000000000000000000000000000000000000000005 220.0
HKD2_k127_2284221_47 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.000000000000000000000000000000000000000000000000000000000002497 219.0
HKD2_k127_2284221_48 MotA/TolQ/ExbB proton channel family K03561 - - 0.00000000000000000000000000000000000000000000000000000000001026 215.0
HKD2_k127_2284221_49 COG1247 Sortase and related acyltransferases K03823 - 2.3.1.183 0.0000000000000000000000000000000000000000000000000000000004987 207.0
HKD2_k127_2284221_5 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 1.017e-308 957.0
HKD2_k127_2284221_50 Phosphate acyltransferases - - - 0.000000000000000000000000000000000000000000000000000000003924 209.0
HKD2_k127_2284221_51 Chalcone isomerase-like - - - 0.0000000000000000000000000000000000000000000000001386 185.0
HKD2_k127_2284221_52 Uncharacterized ACR, COG1430 K09005 - - 0.0000000000000000000000000000000000000000000006337 177.0
HKD2_k127_2284221_53 PFAM Methylated-DNA- protein -cysteine S-methyltransferase DNA binding K00567 - 2.1.1.63 0.000000000000000000000000000000000000000000006401 169.0
HKD2_k127_2284221_54 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation K06891 - - 0.000000000000000000000000000000000000000001247 158.0
HKD2_k127_2284221_55 Peptidyl-prolyl cis-trans K03774 - 5.2.1.8 0.00000000000000000000000000000000000000001167 158.0
HKD2_k127_2284221_56 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.000000000000000000000000000000000000002283 148.0
HKD2_k127_2284221_57 Protein of unknown function (DUF3579) - - - 0.000000000000000000000000000000000001219 153.0
HKD2_k127_2284221_58 'Cold-shock' DNA-binding domain K03704 - - 0.000000000000000000000000000000000003243 138.0
HKD2_k127_2284221_59 Biopolymer transport protein ExbD TolR K03559 - - 0.00000000000000000000000000000003688 136.0
HKD2_k127_2284221_6 PrkA AAA domain K07180 - - 1.603e-278 871.0
HKD2_k127_2284221_60 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.00000000000000000000000006793 114.0
HKD2_k127_2284221_61 Belongs to the bacterial ribosomal protein bL33 family K02913 - - 0.0000000000000000000000009065 104.0
HKD2_k127_2284221_62 Binds directly to 16S ribosomal RNA K02968 - - 0.0000000000000000000001457 100.0
HKD2_k127_2284221_63 Belongs to the UPF0434 family K09791 - - 0.000000000000000000004241 93.0
HKD2_k127_2284221_64 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides K03602 - 3.1.11.6 0.0000000000000000003664 89.0
HKD2_k127_2284221_65 cytochrome K17230 - - 0.0000000000000000005672 93.0
HKD2_k127_2284221_66 META domain - - - 0.000003665 57.0
HKD2_k127_2284221_7 Belongs to the argininosuccinate synthase family. Type 2 subfamily K01940 GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 1.077e-256 796.0
HKD2_k127_2284221_8 Isocitrate dehydrogenase K00031 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 4.563e-237 740.0
HKD2_k127_2284221_9 gamma-glutamyltransferase K00681 - 2.3.2.2,3.4.19.13 1.239e-229 725.0
HKD2_k127_2354857_0 TIGRFAM type I secretion outer membrane protein, TolC family K12340 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004655 261.0
HKD2_k127_2354857_1 transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00000000000000000000000000000000000000000000000000000000000008423 220.0
HKD2_k127_2355335_0 Vitamin B12 dependent methionine synthase activation region K00548 - 2.1.1.13 0.0 1358.0
HKD2_k127_2355335_1 Protein of unknown function (DUF1214) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001269 453.0
HKD2_k127_2355335_2 - - - - 0.00000000000000004218 91.0
HKD2_k127_2355335_3 - - - - 0.0000000000000004847 85.0
HKD2_k127_2413455_0 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 0.0 1429.0
HKD2_k127_2413455_1 Peptidase family M3 K01414 - 3.4.24.70 1.943e-284 888.0
HKD2_k127_2413455_2 PFAM ATP-binding region, ATPase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003404 596.0
HKD2_k127_2413455_3 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate K01491 - 1.5.1.5,3.5.4.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008583 391.0
HKD2_k127_2413455_4 helix_turn_helix, Lux Regulon K13041 GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004896 287.0
HKD2_k127_2413455_5 PFAM Glutaredoxin - - - 0.0000000000000000000000000000000000000002868 155.0
HKD2_k127_2413455_6 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.000000000000000000000000000000000009939 139.0
HKD2_k127_2413455_7 Glutaredoxin - - - 0.000000000000000000000000000000275 132.0
HKD2_k127_2425703_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 1.507e-225 709.0
HKD2_k127_2425703_1 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005339 597.0
HKD2_k127_2425703_10 ANTAR K22010 - - 0.0000000000000000000000000000000000000000000000003498 182.0
HKD2_k127_2425703_11 Response regulator receiver K03413 - - 0.0000000000000000000000000000000000001468 151.0
HKD2_k127_2425703_12 Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways K02403 - - 0.0000000000000000000000000009166 130.0
HKD2_k127_2425703_13 - - - - 0.000000000000000000001609 103.0
HKD2_k127_2425703_14 Cobalt uptake substrate-specific transmembrane region - - - 0.00000000000000000004402 98.0
HKD2_k127_2425703_15 - - - - 0.0000000000000007673 84.0
HKD2_k127_2425703_16 Flagellar protein YcgR - - - 0.00000000000003099 83.0
HKD2_k127_2425703_17 Flagellar protein FliT K02423 - - 0.00000000000188 75.0
HKD2_k127_2425703_18 Flagellar regulator YcgR - - - 0.000000000004935 76.0
HKD2_k127_2425703_2 Aldo/keto reductase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005619 499.0
HKD2_k127_2425703_3 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001514 467.0
HKD2_k127_2425703_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes K02405 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001995 309.0
HKD2_k127_2425703_5 Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways K02402 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000142 289.0
HKD2_k127_2425703_6 PAS fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000014 289.0
HKD2_k127_2425703_7 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006748 272.0
HKD2_k127_2425703_8 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000004757 299.0
HKD2_k127_2425703_9 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000004496 267.0
HKD2_k127_255781_0 Helicase K03722 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009476 326.0
HKD2_k127_255781_1 Protein conserved in bacteria - - - 0.00002681 51.0
HKD2_k127_2584038_0 Peptidase family M3 K01392 - 3.4.24.15 2.208e-195 631.0
HKD2_k127_2584038_1 Thioredoxin K05838 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000105 293.0
HKD2_k127_2584038_2 prohibitin homologues - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003251 261.0
HKD2_k127_2584038_3 Adenosyltransferase K00798 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 0.00000000000000000000000000000000000000000000000000000007181 197.0
HKD2_k127_2584038_4 - - - - 0.00000000000000004457 89.0
HKD2_k127_2584038_5 - - - - 0.000000000000001267 79.0
HKD2_k127_2589244_0 Protein of unknown function (DUF3141) - - - 7.806e-266 831.0
HKD2_k127_2589244_1 Transport of potassium into the cell K03549 - - 1.073e-217 693.0
HKD2_k127_2589244_10 - - - - 0.00000000000000000000000000000008163 131.0
HKD2_k127_2589244_2 Inorganic ion transport and metabolism K03319 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 574.0
HKD2_k127_2589244_3 ABC transporter substrate-binding protein PnrA-like K02058 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000793 501.0
HKD2_k127_2589244_4 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009447 469.0
HKD2_k127_2589244_5 Branched-chain amino acid transport system / permease component K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002092 423.0
HKD2_k127_2589244_6 Belongs to the binding-protein-dependent transport system permease family K02057 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001706 394.0
HKD2_k127_2589244_7 Domain of unknown function (DUF4337) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001945 256.0
HKD2_k127_2589244_8 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000001325 196.0
HKD2_k127_2602538_0 Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily K01890 - 6.1.1.20 1.855e-303 951.0
HKD2_k127_2602538_1 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily K01889 - 6.1.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 550.0
HKD2_k127_2602538_10 Belongs to the bacterial ribosomal protein bL35 family K02916 - - 0.000000000000000000000000005113 113.0
HKD2_k127_2602538_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002302 381.0
HKD2_k127_2602538_3 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates K03787 - 3.1.3.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001696 350.0
HKD2_k127_2602538_4 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins K02520 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005215 267.0
HKD2_k127_2602538_5 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000009654 232.0
HKD2_k127_2602538_6 peptidase K06194 - - 0.00000000000000000000000000000000000000000000000000000000000009635 235.0
HKD2_k127_2602538_7 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit K02887 - - 0.000000000000000000000000000000000000000000000000001513 184.0
HKD2_k127_2602538_8 transcriptional - - - 0.000000000000000000000000000000000000000000000004954 175.0
HKD2_k127_2602538_9 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K04764 - - 0.0000000000000000000000000000000000000000001054 163.0
HKD2_k127_2635387_0 diguanylate cyclase - - - 2.043e-280 894.0
HKD2_k127_2635387_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000006041 234.0
HKD2_k127_2658379_0 Sodium/hydrogen exchanger family K03455,K11745,K11747 - - 8.116e-265 828.0
HKD2_k127_2658379_1 Belongs to the aldehyde dehydrogenase family K00135 - 1.2.1.16,1.2.1.20,1.2.1.79 1.805e-223 707.0
HKD2_k127_2658379_2 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003728 254.0
HKD2_k127_2658379_3 NADPH-quinone reductase (modulator of drug activity B) K00355,K11746,K11748 - 1.6.5.2 0.000000000000000000000000000000000000000000000000000000000000000007717 231.0
HKD2_k127_2662143_0 B12 binding domain K04034 - 1.21.98.3 4.317e-315 970.0
HKD2_k127_2662143_1 Proto-chlorophyllide reductase 57 kD subunit K11335 - 1.3.7.14,1.3.7.15 5.405e-263 827.0
HKD2_k127_2662143_10 phytoene K09845 - 1.3.99.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 561.0
HKD2_k127_2662143_11 Photosynthetic reaction center L subunit K08928 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001539 535.0
HKD2_k127_2662143_12 introduces a magnesium ion into protoporphyrin IX to yield Mg-protoporphyrin IX K03405 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007877 518.0
HKD2_k127_2662143_13 Dehydrogenase K11337 - 1.1.1.396 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 440.0
HKD2_k127_2662143_14 Tat pathway signal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001863 438.0
HKD2_k127_2662143_15 The reaction center of purple bacteria contains a tightly bound cytochrome molecule which re-reduces the photo oxidized primary electron donor K13992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001355 398.0
HKD2_k127_2662143_16 Dimerisation domain K09846 - 2.1.1.210 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005231 379.0
HKD2_k127_2662143_17 Phytoene squalene synthetase K02291 GO:0003674,GO:0003824,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006846 374.0
HKD2_k127_2662143_18 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006947 357.0
HKD2_k127_2662143_19 Serine aminopeptidase, S33 K06049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 352.0
HKD2_k127_2662143_2 Nitrogenase component 1 type Oxidoreductase K11334 - 1.3.7.14,1.3.7.15 4.09e-260 811.0
HKD2_k127_2662143_20 hydroxyneurosporene synthase K09844 - 4.2.1.131 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003921 337.0
HKD2_k127_2662143_21 transcriptional regulator PpsR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 304.0
HKD2_k127_2662143_22 Protein of unknown function (DUF3422) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003749 292.0
HKD2_k127_2662143_23 Protein of unknown function (DUF3623) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004658 256.0
HKD2_k127_2662143_24 Bacteriochlorophyll 4-vinyl reductase K04036 - - 0.000000000000000000000000000000000000000000000000000002188 203.0
HKD2_k127_2662143_25 Heme oxygenase K21480 - 1.14.15.20 0.00000000000000000000000000000000000000000003484 168.0
HKD2_k127_2662143_26 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000000000000000000000000001974 140.0
HKD2_k127_2662143_27 Photosynthetic complex assembly protein - - - 0.0000000000000000000000000000001001 132.0
HKD2_k127_2662143_28 Bacterial PH domain - - - 0.000000000000000000000001316 106.0
HKD2_k127_2662143_29 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.00000000000000000000001347 104.0
HKD2_k127_2662143_3 Flavin containing amine oxidoreductase - - - 2.53e-242 757.0
HKD2_k127_2662143_30 Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers K08926 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000004961 87.0
HKD2_k127_2662143_31 Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers K08927 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000005235 84.0
HKD2_k127_2662143_32 - K08927 - - 0.00000000000002188 75.0
HKD2_k127_2662143_33 PFAM OmpA MotB domain protein - - - 0.0000000007784 72.0
HKD2_k127_2662143_34 CRISPR_assoc K19126 - - 0.0007869 50.0
HKD2_k127_2662143_4 Bacteriophytochrome (Light-regulated signal transduction histidine kinase) - - - 9.845e-239 759.0
HKD2_k127_2662143_5 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) K01662 - 2.2.1.7 3.518e-217 704.0
HKD2_k127_2662143_6 von Willebrand factor type A domain K03404 - 6.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001397 613.0
HKD2_k127_2662143_7 oxidoreductase activity, acting on iron-sulfur proteins as donors K04037,K11333 - 1.3.7.14,1.3.7.15,1.3.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 578.0
HKD2_k127_2662143_8 Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K04035 - 1.14.13.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003536 576.0
HKD2_k127_2662143_9 The reaction center is a membrane-bound complex that mediates the initial photochemical event in the electron transfer process of photosynthesis K08929 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002843 558.0
HKD2_k127_2704022_0 Luciferase-like monooxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 305.0
HKD2_k127_2704022_1 KR domain - - - 0.0000000000000000000000000000000000000000000000000000000000000001101 229.0
HKD2_k127_2782003_0 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K00997,K01207 - 2.7.8.7,3.2.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005053 396.0
HKD2_k127_2782003_1 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 - 2.6.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003218 338.0
HKD2_k127_2782003_2 Involved in DNA repair and RecF pathway recombination K03584 - - 0.000000000000000000000000000000000000000000000000000003509 196.0
HKD2_k127_2782003_3 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.0000000000000000000000000000000000004782 147.0
HKD2_k127_285383_0 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.0 1086.0
HKD2_k127_285383_1 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 7.988e-292 922.0
HKD2_k127_285383_2 Protein of unknown function (DUF1298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002107 578.0
HKD2_k127_285383_3 TIGRFAM acyltransferase, WS DGAT MGAT - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003708 564.0
HKD2_k127_285383_4 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family K00018,K00058 - 1.1.1.29,1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001994 515.0
HKD2_k127_285383_5 Nitronate monooxygenase K00459 - 1.13.12.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001445 471.0
HKD2_k127_285383_6 PGAP1-like protein - - - 0.00000000000000000000126 108.0
HKD2_k127_285383_7 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.0000000000003085 70.0
HKD2_k127_28576_0 heat shock protein binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 373.0
HKD2_k127_28576_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.00000000000003607 85.0
HKD2_k127_2886069_0 Berberine and berberine like - - - 1.063e-271 839.0
HKD2_k127_2886069_1 PFAM 4Fe-4S K00184,K21308 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 463.0
HKD2_k127_2886069_2 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 434.0
HKD2_k127_2886069_3 DMSO reductase anchor subunit (DmsC) K21309 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006665 396.0
HKD2_k127_2886069_4 Bacterial regulatory proteins, luxR family K07684 - - 0.0000000000000000000000000000000000000000000000000000000000000000000002556 248.0
HKD2_k127_2886069_5 Glutathione S-transferase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000005103 243.0
HKD2_k127_2886069_6 Histidine kinase K07673 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000008936 237.0
HKD2_k127_2933478_0 ABC transporter K06020 - 3.6.3.25 1.594e-300 928.0
HKD2_k127_2933478_1 DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001208 532.0
HKD2_k127_2933478_2 bacterial-type flagellum-dependent cell motility - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 305.0
HKD2_k127_2933478_3 Psort location CytoplasmicMembrane, score 9.46 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009796 264.0
HKD2_k127_2933478_4 GCN5-related N-acetyl-transferase K06975 - - 0.0000000000000000000003063 104.0
HKD2_k127_2933478_5 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 K15461 - 2.1.1.61 0.0000007482 53.0
HKD2_k127_2941498_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1099.0
HKD2_k127_2941498_1 heavy metal translocating P-type ATPase K17686 - 3.6.3.54 3.352e-320 996.0
HKD2_k127_2941498_10 Exodeoxyribonuclease III xth K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002618 365.0
HKD2_k127_2941498_11 gluconolactonase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003252 363.0
HKD2_k127_2941498_12 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989 - 2.7.7.56 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003918 344.0
HKD2_k127_2941498_13 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000885 342.0
HKD2_k127_2941498_14 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001211 329.0
HKD2_k127_2941498_15 Domain of unknown function (DUF1732) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007232 317.0
HKD2_k127_2941498_16 Essential for recycling GMP and indirectly, cGMP K00942 - 2.7.4.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001004 303.0
HKD2_k127_2941498_17 Methyltransferase type 12 K03439 GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008757,GO:0016278,GO:0016740,GO:0016741,GO:0032259 2.1.1.33 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006877 312.0
HKD2_k127_2941498_18 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length K04760 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003736 263.0
HKD2_k127_2941498_19 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.0000000000000000000000000000000000000000000000000000000000000000000000000005291 260.0
HKD2_k127_2941498_2 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K01139 - 2.7.6.5,3.1.7.2 1.088e-294 922.0
HKD2_k127_2941498_20 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001071 265.0
HKD2_k127_2941498_21 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000684 243.0
HKD2_k127_2941498_22 Type VI secretion system effector, Hcp K11903 - - 0.0000000000000000000000000000000000000000000000002426 185.0
HKD2_k127_2941498_23 methyltransferase activity - - - 0.00000000000000000000000000000000000000000000848 170.0
HKD2_k127_2941498_24 Belongs to the peptidase M12A family - - - 0.00000000000000000000000000000000000000002758 157.0
HKD2_k127_2941498_25 - - - - 0.00000000000000000000000000000000000000007899 157.0
HKD2_k127_2941498_26 COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - 0.000000000000000000000000000000000001925 143.0
HKD2_k127_2941498_27 Transcriptional K08365 - - 0.0000000000000000000000000000004129 132.0
HKD2_k127_2941498_28 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.00000000000000000000000000004942 117.0
HKD2_k127_2941498_29 amine dehydrogenase activity K13730 - - 0.000000000000000000000000001138 126.0
HKD2_k127_2941498_3 TIGRFAM glutamine synthetase, type I K01915,K20712 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 1.954e-262 812.0
HKD2_k127_2941498_30 ATP-independent chaperone mediated protein folding - - - 0.00000000000000001749 89.0
HKD2_k127_2941498_31 Protein of unknown function (DUF2933) - - - 0.000000000000001269 82.0
HKD2_k127_2941498_32 member of a two-component regulatory system K02484,K07644 GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0033554,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 0.0000000000058 74.0
HKD2_k127_2941498_33 Caspase domain - - - 0.0000001048 63.0
HKD2_k127_2941498_34 Short C-terminal domain - - - 0.000001669 53.0
HKD2_k127_2941498_36 BRO family, N-terminal domain K07741 - - 0.0005415 49.0
HKD2_k127_2941498_4 Sigma-54 interaction domain K07712 GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - 3.393e-222 700.0
HKD2_k127_2941498_5 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000152 622.0
HKD2_k127_2941498_6 Involved in the biosynthesis of porphyrin-containing compound - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009104 540.0
HKD2_k127_2941498_7 Protein tyrosine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002325 430.0
HKD2_k127_2941498_8 Signal transduction histidine kinase, nitrogen specific K07708 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 423.0
HKD2_k127_2941498_9 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002555 385.0
HKD2_k127_2946880_0 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - 4.186e-284 900.0
HKD2_k127_2946880_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 7.955e-243 769.0
HKD2_k127_2946880_10 COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001067 266.0
HKD2_k127_2946880_11 Belongs to the Dps family K04047 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002575 250.0
HKD2_k127_2946880_12 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001209 261.0
HKD2_k127_2946880_13 Domain of Unknown Function (DUF349) - - - 0.000000000000000000000000000000000000000000000000000000000007598 236.0
HKD2_k127_2946880_14 Protein of unknown function (DUF1499) - - - 0.0000000000000000000000000000000000000000000000000005083 192.0
HKD2_k127_2946880_15 endoribonuclease K09022 - 3.5.99.10 0.000000000000000000000000000000000000000000001167 168.0
HKD2_k127_2946880_16 - - - - 0.00000000000000000000000000000000000000000785 159.0
HKD2_k127_2946880_17 Helix-turn-helix XRE-family like proteins - - - 0.00000000000000000000000000000000000000003611 164.0
HKD2_k127_2946880_18 Cysteine-rich secretory protein family - - - 0.0000000000000000000000000000000000000004642 159.0
HKD2_k127_2946880_19 Glycosyltransferase like family 2 - - - 0.0000000000000000000000000000000000005311 151.0
HKD2_k127_2946880_2 Glucose / Sorbosone dehydrogenase - - - 1.521e-235 733.0
HKD2_k127_2946880_20 Phasin protein - - - 0.0000000000000000000000000000003269 129.0
HKD2_k127_2946880_21 PFAM Cytochrome C K17230 - - 0.00000000000000000000000000005617 120.0
HKD2_k127_2946880_22 F420H(2)-dependent quinone reductase - - - 0.0000000000000006015 86.0
HKD2_k127_2946880_23 epimerase K00091 - 1.1.1.219 0.0000124 56.0
HKD2_k127_2946880_3 TonB-dependent Receptor Plug K02014 - - 4.85e-217 696.0
HKD2_k127_2946880_4 COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases K06016 - 3.5.1.6,3.5.1.87 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 504.0
HKD2_k127_2946880_5 Protein of unknown function (DUF3641) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008685 473.0
HKD2_k127_2946880_6 LysR family K04761 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 458.0
HKD2_k127_2946880_7 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase K00020,K00042 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006573,GO:0006574,GO:0006807,GO:0008150,GO:0008152,GO:0008442,GO:0009056,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0055114,GO:0070013,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.1.1.31,1.1.1.60 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001206 450.0
HKD2_k127_2946880_8 Putative diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 424.0
HKD2_k127_2946880_9 pyridine nucleotide-disulfide oxidoreductase family protein K17218 - 1.8.5.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003214 312.0
HKD2_k127_3052958_0 Helix-turn-helix domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001869 274.0
HKD2_k127_3052958_1 Predicted membrane protein (DUF2157) - - - 0.000000000000000000000000000000000000000000005334 181.0
HKD2_k127_3052958_2 PFAM adenylyl cyclase class-3 4 guanylyl cyclase K01768 - 4.6.1.1 0.000000000001958 69.0
HKD2_k127_3052958_3 GDYXXLXY protein - - - 0.0000003747 63.0
HKD2_k127_3075095_0 NADH flavin oxidoreductase NADH oxidase K10680 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004712 307.0
HKD2_k127_3075095_1 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.00000000000000000000000000000000000000000000000000000000000000000009645 237.0
HKD2_k127_3078614_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 3.587e-300 935.0
HKD2_k127_3078614_1 phosphinothricin N-acetyltransferase activity K03823,K06718 - 2.3.1.178,2.3.1.183 0.00000000000000000000000000000004893 133.0
HKD2_k127_3160116_0 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 368.0
HKD2_k127_3160116_1 Concanavalin A-like lectin/glucanases superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002657 290.0
HKD2_k127_326207_0 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02621 - - 5e-324 1009.0
HKD2_k127_326207_1 Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule K02622 - - 3.097e-319 987.0
HKD2_k127_326207_10 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009809 355.0
HKD2_k127_326207_11 Belongs to the RNA methyltransferase TrmD family K00554 - 2.1.1.228 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003308 321.0
HKD2_k127_326207_12 Pfam:UPF0118 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004325 326.0
HKD2_k127_326207_13 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004807 309.0
HKD2_k127_326207_14 PFAM Rubrerythrin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001849 265.0
HKD2_k127_326207_15 3'-to-5' exoribonuclease specific for small oligoribonucleotides K13288 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004264 271.0
HKD2_k127_326207_16 Protein of unknown function (DUF3501) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003102 254.0
HKD2_k127_326207_17 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000003397 259.0
HKD2_k127_326207_18 PFAM NUDIX hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008576 254.0
HKD2_k127_326207_19 Proline racemase - - - 0.000000000000000000000000000000000000000000000000000000000000000006106 237.0
HKD2_k127_326207_2 Molecular chaperone. Has ATPase activity K04079 - - 5.641e-295 919.0
HKD2_k127_326207_20 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site K02884 - - 0.00000000000000000000000000000000000000000000000000000000000188 211.0
HKD2_k127_326207_21 glycosylase K03649 - 3.2.2.28 0.00000000000000000000000000000000000000000000000000001989 193.0
HKD2_k127_326207_22 Copper resistance protein D - - - 0.0000000000000000000000000000000000001828 145.0
HKD2_k127_326207_23 Pterin 4 alpha carbinolamine dehydratase K01724 - 4.2.1.96 0.00000000000000000000000000000000002734 140.0
HKD2_k127_326207_24 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000000000000000001716 136.0
HKD2_k127_326207_25 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.000000000000000000000000000002068 130.0
HKD2_k127_326207_26 Putative prokaryotic signal transducing protein - - - 0.000000000000000000000000001081 123.0
HKD2_k127_326207_27 membrane - - - 0.00000000000000000000001158 102.0
HKD2_k127_326207_28 TM2 domain - - - 0.00000000000000000006359 96.0
HKD2_k127_326207_3 PFAM Acyl-CoA dehydrogenase N terminal, Acyl-CoA dehydrogenase, C-terminal domain, Acyl-CoA dehydrogenase, middle domain, Acyl-CoA dehydrogenase, N-terminal domain K20035 - - 6.342e-268 836.0
HKD2_k127_326207_4 Cysteine-rich domain - - - 1.54e-206 651.0
HKD2_k127_326207_5 CAAX prenyl protease N-terminal, five membrane helices K06013 - 3.4.24.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 514.0
HKD2_k127_326207_6 Electron transfer flavoprotein, alpha subunit K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 458.0
HKD2_k127_326207_7 Diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 482.0
HKD2_k127_326207_8 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004682 453.0
HKD2_k127_326207_9 PFAM Electron transfer flavoprotein alpha beta-subunit K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001474 420.0
HKD2_k127_3278526_0 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines K05540 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005883 463.0
HKD2_k127_3278526_1 AICARFT/IMPCHase bienzyme K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005835 421.0
HKD2_k127_3278526_2 Nucleotidyl transferase K00992 - 2.7.7.99 0.00000000000000000000000000000000000000000000000000000000000000000000001385 248.0
HKD2_k127_3278526_3 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family K03185 - - 0.00000000000000000000000000000000000000000000000000000000000000000003647 246.0
HKD2_k127_3278526_4 Belongs to the transcriptional regulatory Fis family K03557 - - 0.00000000000000005327 94.0
HKD2_k127_3302154_0 PFAM Adenylate and Guanylate cyclase catalytic domain - - - 0.000000000000000000003377 108.0
HKD2_k127_3307475_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1133.0
HKD2_k127_3307475_1 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 2.318e-303 944.0
HKD2_k127_3307475_10 CoA-binding protein K06929 - - 0.0000000000000000000000000000000000000000000000000000000000000525 217.0
HKD2_k127_3307475_11 - - - - 0.0000000000000000000000000000000000000000000000000000000000006639 222.0
HKD2_k127_3307475_12 Belongs to the ompA family K03286 - - 0.0000000000000000000000000000000000000000000000000005756 186.0
HKD2_k127_3307475_13 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000002104 184.0
HKD2_k127_3307475_14 diguanylate cyclase - - - 0.0000000000000000000000000000000000000008675 166.0
HKD2_k127_3307475_15 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000003046 146.0
HKD2_k127_3307475_16 membrane - - - 0.0000000000000000000000000000917 118.0
HKD2_k127_3307475_17 - - - - 0.0000000000008042 78.0
HKD2_k127_3307475_18 - - - - 0.00000000001071 69.0
HKD2_k127_3307475_19 regulation of single-species biofilm formation - - - 0.0004874 46.0
HKD2_k127_3307475_2 AsmA family - - - 1.175e-233 767.0
HKD2_k127_3307475_3 TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase K01740 - 2.5.1.49 1.817e-202 646.0
HKD2_k127_3307475_4 Domain of unknown function (DUF3482) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008636 502.0
HKD2_k127_3307475_6 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001859 329.0
HKD2_k127_3307475_7 O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002637 325.0
HKD2_k127_3307475_8 Protein of unknown function (DUF2868) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003981 287.0
HKD2_k127_3307475_9 Phosphoglycolate phosphatase K22292 - 3.1.3.105 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001912 271.0
HKD2_k127_3356449_0 Belongs to the aspartokinase family K00928 GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576 2.7.2.4 5.275e-204 641.0
HKD2_k127_3356449_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002288 542.0
HKD2_k127_3356449_2 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine K04075 - 6.3.4.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001409 348.0
HKD2_k127_3356449_3 pathogenesis - - - 0.0000000000000000000000000000000000000000000000005476 183.0
HKD2_k127_3356449_4 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000001566 196.0
HKD2_k127_3356449_5 acetyltransferase - - - 0.000000000000000000000009613 117.0
HKD2_k127_3356449_6 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.0000000000007345 82.0
HKD2_k127_3356449_7 - - - - 0.0000000000223 74.0
HKD2_k127_3358896_0 GntP family permease - - - 3.185e-224 703.0
HKD2_k127_3358896_1 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001882 509.0
HKD2_k127_3358896_10 Bacterial regulatory helix-turn-helix protein, lysR family K02623 - - 0.00000000000000000000000000000000000007623 155.0
HKD2_k127_3358896_11 mechanosensitive ion channel - - - 0.000001268 55.0
HKD2_k127_3358896_12 Chorismate mutase K00014,K00891,K04092,K04516 - 1.1.1.25,2.7.1.71,5.4.99.5 0.00008226 45.0
HKD2_k127_3358896_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001396 417.0
HKD2_k127_3358896_3 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002251 384.0
HKD2_k127_3358896_4 Transcriptional regulator K13634 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002268 382.0
HKD2_k127_3358896_5 Glyoxalase bleomycin resistance protein dioxygenase K08234 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003205 320.0
HKD2_k127_3358896_6 esterase K01432 - 3.5.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001741 313.0
HKD2_k127_3358896_7 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.000000000000000000000000000000000000000000000000000000000000000000000000000002364 273.0
HKD2_k127_3358896_8 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0000000000000000000000000000000000000000000000000000000005462 203.0
HKD2_k127_3358896_9 Phospholipase_D-nuclease N-terminal - - - 0.00000000000000000000000000000000000000000000000004505 180.0
HKD2_k127_3360570_0 PFAM cytochrome bd ubiquinol oxidase subunit I K00425 - 1.10.3.14 8.484e-200 631.0
HKD2_k127_3360570_1 cytochrome d ubiquinol oxidase, subunit II K00426 - 1.10.3.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001712 475.0
HKD2_k127_3360570_2 Thi4 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004842 295.0
HKD2_k127_3360570_3 membrane - - - 0.000000000000000002221 88.0
HKD2_k127_3360570_4 Oxidizes proline to glutamate for use as a carbon and nitrogen source K00249,K00294,K13821 - 1.2.1.88,1.3.8.7,1.5.5.2 0.00007549 48.0
HKD2_k127_3421618_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 8.205e-198 622.0
HKD2_k127_3421618_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003198 486.0
HKD2_k127_3421618_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K02573 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004076 319.0
HKD2_k127_3421618_3 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000000000001053 155.0
HKD2_k127_3421618_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.0000000000000000000000000137 112.0
HKD2_k127_3491357_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007921 320.0
HKD2_k127_3491357_1 Glutathione S-Transferase K00799 - 2.5.1.18 0.0000000000000000000000000000000000000000000000000002566 188.0
HKD2_k127_3491357_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.00000000000000000000000000000000000000000002215 171.0
HKD2_k127_349318_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 GO:0000183,GO:0001302,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007568,GO:0007569,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0016874,GO:0016879,GO:0018130,GO:0019219,GO:0019222,GO:0019357,GO:0019358,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032502,GO:0034641,GO:0034654,GO:0040029,GO:0043094,GO:0043173,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046497,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0051276,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.3.4.21 3.722e-205 644.0
HKD2_k127_349318_1 Branched-chain amino acid transport system / permease component K01997,K01998 - - 2.488e-204 653.0
HKD2_k127_349318_10 D-isomer specific 2-hydroxyacid dehydrogenase K00015,K00090 - 1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000393 377.0
HKD2_k127_349318_11 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate K10773 - 4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009502 336.0
HKD2_k127_349318_12 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003422 263.0
HKD2_k127_349318_13 LUD domain K00782 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003542 251.0
HKD2_k127_349318_14 Peptidase_C39 like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002555 255.0
HKD2_k127_349318_15 Asp/Glu/Hydantoin racemase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005276 249.0
HKD2_k127_349318_16 ABC transporter K01995 - - 0.00000000000000000000000000000000000000000000000000000000000000000000449 260.0
HKD2_k127_349318_17 Part of a membrane complex involved in electron transport K03616 - - 0.000000000000000000000000000000000000000000000000000000000000000000005457 241.0
HKD2_k127_349318_18 ABC-type branched-chain amino acid transport systems ATPase component K01996 - - 0.000000000000000000000000000000000000000000000000000000001667 216.0
HKD2_k127_349318_19 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions K05524 - - 0.00000000000000000000000000000000000000000000000000000002811 201.0
HKD2_k127_349318_2 Extracellular liganD-binding receptor K01999 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 613.0
HKD2_k127_349318_20 Domain of unknown function (DUF1841) - - - 0.0000000000000000000000000000000000000000000000000003992 188.0
HKD2_k127_349318_21 PFAM Cytochrome c, class I - - - 0.00000000000000000000000008728 112.0
HKD2_k127_349318_22 cytochrome - - - 0.000000000000000000000001988 106.0
HKD2_k127_349318_23 - - - - 0.000002502 54.0
HKD2_k127_349318_3 VWA domain containing CoxE-like protein K09989 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002931 568.0
HKD2_k127_349318_4 Sodium proton antiporter, NhaD family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 568.0
HKD2_k127_349318_5 de-polymerase K05973 - 3.1.1.75 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006073 562.0
HKD2_k127_349318_6 type II secretion system protein E K02454,K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000513 546.0
HKD2_k127_349318_7 ATPase associated with various cellular activities, AAA_5 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 491.0
HKD2_k127_349318_8 Pyridoxal-phosphate dependent enzyme K01505,K05396,K17950 - 3.5.99.7,4.4.1.15,4.4.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 475.0
HKD2_k127_349318_9 DegT/DnrJ/EryC1/StrS aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002264 398.0
HKD2_k127_3686403_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003967 597.0
HKD2_k127_3686403_1 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling K09001 - 2.7.1.170 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006842 377.0
HKD2_k127_3686403_10 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 - - 0.00000000000000000000000000000000000000000000000000000003651 201.0
HKD2_k127_3686403_11 Gram-negative porin - GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000005334 205.0
HKD2_k127_3686403_12 Gram-negative porin - - - 0.0000000000000000000000000000000000000000000000004501 193.0
HKD2_k127_3686403_13 - - - - 0.0000000000000000000000000000000000000000000804 168.0
HKD2_k127_3686403_14 Domain of unknown function (DUF4010) - - - 0.00000000000000000000000000000000000003488 148.0
HKD2_k127_3686403_15 Integral membrane protein CcmA involved in cell shape determination - - - 0.000000000000000000000000000000001619 133.0
HKD2_k127_3686403_16 repeat-containing protein - - - 0.00000000000000000000000006463 113.0
HKD2_k127_3686403_2 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001012 367.0
HKD2_k127_3686403_3 Phospholipid-binding protein K06910 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000566 309.0
HKD2_k127_3686403_4 Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol K06134 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001984 256.0
HKD2_k127_3686403_5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 - - 0.00000000000000000000000000000000000000000000000000000000000000000003814 240.0
HKD2_k127_3686403_6 Ribosomal protein S9/S16 K02996 - - 0.0000000000000000000000000000000000000000000000000000000000000007863 221.0
HKD2_k127_3686403_7 Required for insertion of 4Fe-4S clusters K15724 - - 0.00000000000000000000000000000000000000000000000000000000000183 211.0
HKD2_k127_3686403_8 Phosphoglycerate mutase K15634 - 5.4.2.12 0.00000000000000000000000000000000000000000000000000000000007799 214.0
HKD2_k127_3686403_9 redox protein, regulator of disulfide bond formation K07397 - - 0.000000000000000000000000000000000000000000000000000000000513 204.0
HKD2_k127_369919_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 0.0 1540.0
HKD2_k127_369919_1 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 3.195e-289 909.0
HKD2_k127_369919_10 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.000000000000000000000000000000000000000000000000000000000000000000721 234.0
HKD2_k127_369919_12 Chaperone protein TorD - - - 0.00000000000000000000000000000007745 132.0
HKD2_k127_369919_13 Protein of unknown function (DUF3305) - - - 0.0000000000000000000000000235 119.0
HKD2_k127_369919_14 Protein of unknown function (DUF3306) - - - 0.0000000000000000000004333 105.0
HKD2_k127_369919_15 Protein of unknown function (DUF3455) - - - 0.000000000000000000002256 102.0
HKD2_k127_369919_16 PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein K00124,K07307 - - 0.00000007661 55.0
HKD2_k127_369919_2 4Fe-4S dicluster domain - - - 4.418e-227 722.0
HKD2_k127_369919_3 COG1541 Coenzyme F390 synthetase K01912 - 6.2.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001991 582.0
HKD2_k127_369919_4 MoeA domain protein domain I and II K03750,K07219 - 2.10.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000591 580.0
HKD2_k127_369919_5 PFAM regulatory protein, LysR K07219 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006843 448.0
HKD2_k127_369919_6 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH K02379 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003661 395.0
HKD2_k127_369919_7 Bacterial extracellular solute-binding protein K05772 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009345 391.0
HKD2_k127_369919_8 binding-protein-dependent transport systems inner membrane component K05773,K06857 - 3.6.3.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000345 329.0
HKD2_k127_369919_9 Belongs to the ABC transporter superfamily K06857 - 3.6.3.55 0.000000000000000000000000000000000000000000000000000000000000000000007857 242.0
HKD2_k127_3733133_0 Feruloyl esterase - - - 1.124e-195 625.0
HKD2_k127_3733133_1 PFAM Methyltransferase type 11 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000356 394.0
HKD2_k127_3733133_10 - - - - 0.0000000000000000000000000000000000000000000000001135 187.0
HKD2_k127_3733133_11 F420H(2)-dependent quinone reductase - - - 0.000000000000000000000000000000000000132 148.0
HKD2_k127_3733133_12 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 0.0000000000000000000000000000002869 127.0
HKD2_k127_3733133_13 - - - - 0.000000000000000000000000009302 118.0
HKD2_k127_3733133_14 - - - - 0.0000000000000000001319 95.0
HKD2_k127_3733133_2 LysE type translocator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000156 313.0
HKD2_k127_3733133_3 Protein of unknown function (DUF4256) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003505 277.0
HKD2_k127_3733133_4 cyclopropane-fatty-acyl-phospholipid synthase K16868 - 2.1.1.265 0.000000000000000000000000000000000000000000000000000000000000000000002382 240.0
HKD2_k127_3733133_5 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000000000000000000000000000000000000000003771 217.0
HKD2_k127_3733133_6 Glutathione-dependent formaldehyde-activating - - - 0.00000000000000000000000000000000000000000000000000000000004128 208.0
HKD2_k127_3733133_7 Glutathione-dependent formaldehyde-activating - - - 0.0000000000000000000000000000000000000000000000000000001959 196.0
HKD2_k127_3733133_8 SnoaL-like domain - - - 0.000000000000000000000000000000000000000000000000001082 186.0
HKD2_k127_3733133_9 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.00000000000000000000000000000000000000000000000001056 182.0
HKD2_k127_3796079_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - 2.507e-261 814.0
HKD2_k127_3796079_1 Beta-lactamase superfamily domain K00784 - 3.1.26.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 434.0
HKD2_k127_3796079_2 methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004994 320.0
HKD2_k127_3796079_3 hydrolase activity, acting on ester bonds - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002237 317.0
HKD2_k127_3796079_4 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00000000000000000002862 97.0
HKD2_k127_3796079_5 COG2010 Cytochrome c, mono- and diheme variants - - - 0.000000000000000002491 90.0
HKD2_k127_3863642_0 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002807 374.0
HKD2_k127_3863642_1 PFAM thioesterase superfamily protein K10806 - - 0.0000000000000000000000000000000000000000000000000762 179.0
HKD2_k127_3863642_2 3-hydroxyacyl-CoA dehydrogenase K07516 - 1.1.1.35 0.0000000000000000000000008555 108.0
HKD2_k127_3872792_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.0 1126.0
HKD2_k127_3872792_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004046 313.0
HKD2_k127_3872792_2 Tetratricopeptide repeat - - - 0.000000000000000000000000000000009236 140.0
HKD2_k127_3872792_3 Sodium:solute symporter family - - - 0.0000000000000000000000000000003809 128.0
HKD2_k127_3872792_4 membrane - - - 0.000000000000000000000000000002219 122.0
HKD2_k127_3872792_5 Psort location Cytoplasmic, score K07505 - - 0.0000000000000000004118 103.0
HKD2_k127_3872792_6 Psort location Cytoplasmic, score K06919 - - 0.000000000000006762 89.0
HKD2_k127_3872792_7 - - - - 0.00000000007948 67.0
HKD2_k127_3875049_0 synthetase K01907 - 6.2.1.16 8.185e-275 877.0
HKD2_k127_3875049_1 ATPase components of ABC transporters with duplicated ATPase domains K15738 - - 3.076e-200 640.0
HKD2_k127_3875049_2 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004238 529.0
HKD2_k127_3875049_3 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000004528 237.0
HKD2_k127_3875049_4 - - - - 0.000000000000000000000000000000000000000000009161 170.0
HKD2_k127_3875049_5 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000004447 130.0
HKD2_k127_3875049_6 Thiol-disulfide isomerase K00384 - 1.8.1.9 0.00000000000000000000009556 104.0
HKD2_k127_3875049_7 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000002929 80.0
HKD2_k127_3917252_0 molybdopterin cofactor binding K08352 - 1.8.5.5 4.774e-313 973.0
HKD2_k127_3917252_1 COG0457 FOG TPR repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000806 531.0
HKD2_k127_3917252_10 Polysulphide reductase, NrfD - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 318.0
HKD2_k127_3917252_11 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008359 290.0
HKD2_k127_3917252_12 Major Facilitator - - - 0.000000000000000000000000000000000000000000000000000000000000000007558 243.0
HKD2_k127_3917252_13 - K07112 - - 0.0000000000000000000000000000000000000000000004474 173.0
HKD2_k127_3917252_14 alpha/beta hydrolase fold - - - 0.000000000000000000000000000000000000002082 158.0
HKD2_k127_3917252_15 Transglycosylase associated protein - - - 0.0000000000000000000000000000000000006332 141.0
HKD2_k127_3917252_16 translation initiation factor activity K06996 - - 0.00000000000000000000000000000000003462 151.0
HKD2_k127_3917252_17 Rhodanese Homology Domain - - - 0.0000000000000000000000000000000000476 140.0
HKD2_k127_3917252_18 Sulphur transport K07112 - - 0.00000000000000000008501 94.0
HKD2_k127_3917252_19 - - - - 0.000000000000000000278 96.0
HKD2_k127_3917252_2 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 499.0
HKD2_k127_3917252_20 - - - - 0.000000000000001636 85.0
HKD2_k127_3917252_21 Protein of unknown function (DUF4255) - - - 0.0000001062 60.0
HKD2_k127_3917252_3 His Kinase A (phosphoacceptor) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 520.0
HKD2_k127_3917252_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003394 437.0
HKD2_k127_3917252_5 AAA domain K07028 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000178 401.0
HKD2_k127_3917252_6 thiosulfate sulfurtransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001202 387.0
HKD2_k127_3917252_7 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006985 338.0
HKD2_k127_3917252_8 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009166 331.0
HKD2_k127_3917252_9 4 iron, 4 sulfur cluster binding K04014,K08353,K08358,K16293 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001258 312.0
HKD2_k127_3933968_0 Tellurite resistance protein TerB - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009028 309.0
HKD2_k127_3937111_0 Nickel-dependent hydrogenase K06281 - 1.12.99.6 4.684e-318 981.0
HKD2_k127_3937111_1 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 1.928e-302 945.0
HKD2_k127_3937111_10 NAD(P)H-binding - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001106 616.0
HKD2_k127_3937111_11 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003283 609.0
HKD2_k127_3937111_12 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004013 531.0
HKD2_k127_3937111_13 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00244 - 1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001727 494.0
HKD2_k127_3937111_14 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008937 487.0
HKD2_k127_3937111_15 serine protease K07403 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009635 491.0
HKD2_k127_3937111_16 Sodium:sulfate symporter transmembrane region K11106,K14445 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001625 483.0
HKD2_k127_3937111_17 Outer membrane efflux protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003192 449.0
HKD2_k127_3937111_18 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003922 429.0
HKD2_k127_3937111_19 Hydrogenase accessory protein HypB K04652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000802 422.0
HKD2_k127_3937111_2 Fumarase C C-terminus K01744 - 4.3.1.1 5.743e-271 838.0
HKD2_k127_3937111_20 FAD dependent oxidoreductase K19746 - 1.4.99.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002185 415.0
HKD2_k127_3937111_21 2Fe-2S iron-sulfur cluster binding domain K00245 - 1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002097 397.0
HKD2_k127_3937111_22 PFAM band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006336 402.0
HKD2_k127_3937111_23 Biotin-lipoyl like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 388.0
HKD2_k127_3937111_24 hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002354 352.0
HKD2_k127_3937111_25 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004458 322.0
HKD2_k127_3937111_26 phosphatidate phosphatase activity K09474,K19302 - 3.1.3.2,3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000141 287.0
HKD2_k127_3937111_27 Belongs to the peptidase S51 family K05995 - 3.4.13.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000001133 266.0
HKD2_k127_3937111_28 helix_turn_helix, cAMP Regulatory protein K01420 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005429 265.0
HKD2_k127_3937111_29 Prokaryotic cytochrome b561 K03620 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001866 263.0
HKD2_k127_3937111_3 Prolyl oligopeptidase family - - - 5.818e-250 789.0
HKD2_k127_3937111_30 Bacterial periplasmic substrate-binding proteins K02030,K10001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002352 283.0
HKD2_k127_3937111_31 PFAM HupH hydrogenase expression protein K03618 - - 0.00000000000000000000000000000000000000000000000000000000000000008375 237.0
HKD2_k127_3937111_32 phosphinothricin N-acetyltransferase activity K09181 - - 0.0000000000000000000000000000000000000000000000000000000000002096 222.0
HKD2_k127_3937111_33 membrane - - - 0.000000000000000000000000000000000000000000000000000000000002029 216.0
HKD2_k127_3937111_34 Hydrogenase maturation protease K03605 - - 0.000000000000000000000000000000000000000000000000000000000012 213.0
HKD2_k127_3937111_35 Single cache domain 3 - - - 0.0000000000000000000000000000000000000000000000000000000001056 214.0
HKD2_k127_3937111_36 PFAM DinB family - - - 0.000000000000000000000000000000000000000000000000000000006465 204.0
HKD2_k127_3937111_37 Ni,Fe-hydrogenase I large subunit - - - 0.00000000000000000000000000000000000000000000000000000008359 209.0
HKD2_k127_3937111_38 - - - - 0.000000000000000000000000000000000000000000000000000001168 209.0
HKD2_k127_3937111_39 Domain in cystathionine beta-synthase and other proteins. - - - 0.000000000000000000000000000000000000000000000003624 176.0
HKD2_k127_3937111_4 Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane K07791,K07792 - - 7.446e-246 764.0
HKD2_k127_3937111_40 Protein of unknown function (DUF3302) - - - 0.00000000000000000000000000000000001518 142.0
HKD2_k127_3937111_41 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0000000000000000000000000000000007638 133.0
HKD2_k127_3937111_42 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009898,GO:0010467,GO:0016020,GO:0016151,GO:0019538,GO:0019897,GO:0019898,GO:0031234,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1901564 - 0.000000000000000000000000000000004535 141.0
HKD2_k127_3937111_43 Hydrogenase-1 expression protein HyaE - - - 0.000000000000000000000000000000006293 138.0
HKD2_k127_3937111_44 PFAM Cyclic nucleotide-binding - - - 0.000000000000000000000000000001225 128.0
HKD2_k127_3937111_45 [NiFe]-hydrogenase assembly, chaperone, HybE - - - 0.00000000000000000000000000000157 127.0
HKD2_k127_3937111_46 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.000000000000000000000000007016 112.0
HKD2_k127_3937111_47 Protein of unknown function (DUF2892) - - - 0.00000000000000000000000002694 110.0
HKD2_k127_3937111_48 HupF/HypC family K04653 - - 0.000000000000000000000000166 108.0
HKD2_k127_3937111_49 Helix-turn-helix K21498 - - 0.000000000000000000000000971 108.0
HKD2_k127_3937111_5 PFAM Sulfate transporter antisigma-factor antagonist STAS - - - 3.135e-236 743.0
HKD2_k127_3937111_50 Hydrogenase assembly chaperone hypC hupF K04653 - - 0.000000000000000000000001158 106.0
HKD2_k127_3937111_51 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000001696 103.0
HKD2_k127_3937111_52 Belongs to the rubredoxin family - - - 0.0000000000000000000001834 99.0
HKD2_k127_3937111_53 Ion channel - - - 0.000000000000000000001009 100.0
HKD2_k127_3937111_54 - - - - 0.00000000003605 67.0
HKD2_k127_3937111_55 - - - - 0.00000000094 62.0
HKD2_k127_3937111_6 Sodium:sulfate symporter transmembrane region K11106,K14445 - - 1.846e-222 700.0
HKD2_k127_3937111_7 Belongs to the HypD family K04654 - - 6.728e-198 625.0
HKD2_k127_3937111_8 Belongs to the enoyl-CoA hydratase isomerase family K19640 - - 5.74e-197 633.0
HKD2_k127_3937111_9 PFAM peptidase S8 and S53, subtilisin, kexin, sedolisin - - - 1.282e-195 647.0
HKD2_k127_3973174_0 Belongs to the bacterial histone-like protein family - - - 0.00000000000000000000000000000000003513 138.0
HKD2_k127_3973174_1 Protein of unknown function (DUF1203) - - - 0.000000000000000000009335 94.0
HKD2_k127_3973174_2 positive regulation of macromolecule biosynthetic process K03973 - - 0.0000000000008386 76.0
HKD2_k127_3985748_0 elongation factor G K02355 - - 2.5e-305 949.0
HKD2_k127_3985748_1 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 K15461 - 2.1.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007854 490.0
HKD2_k127_3985748_10 - - - - 0.000003462 50.0
HKD2_k127_3985748_2 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001383 398.0
HKD2_k127_3985748_3 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000925 360.0
HKD2_k127_3985748_4 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000145 341.0
HKD2_k127_3985748_5 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001624 327.0
HKD2_k127_3985748_6 fad dependent oxidoreductase K07137 - - 0.00000000000000000000000000000000000000000000000000000000000000000000002131 244.0
HKD2_k127_3985748_7 Patatin phospholipase - - - 0.0000000000000000000000000000000000000000000000000000000000008881 224.0
HKD2_k127_3985748_8 'Cold-shock' DNA-binding domain K03704 - - 0.0000000000000000000000000007535 113.0
HKD2_k127_3985748_9 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.0000000000000000005811 90.0
HKD2_k127_3987816_0 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.0 1451.0
HKD2_k127_3987816_1 2-methylcitrate dehydratase K01720 - 4.2.1.79 7.109e-250 784.0
HKD2_k127_3987816_10 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000129 308.0
HKD2_k127_3987816_11 Permease MlaE K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002978 273.0
HKD2_k127_3987816_12 COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - 0.0000000000000000000000000000000000000000000000000000000000002423 217.0
HKD2_k127_3987816_13 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000000000000000000000002259 207.0
HKD2_k127_3987816_14 Uncharacterized protein conserved in bacteria (DUF2237) K09966 - - 0.0000000000000000000000000000000000000000000000002924 187.0
HKD2_k127_3987816_15 Cupin domain - - - 0.0000000000000000000000000000000000000000000000005714 180.0
HKD2_k127_3987816_16 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000000004177 181.0
HKD2_k127_3987816_17 Succinate dehydrogenase cytochrome b556 subunit K00241 - - 0.0000000000000000000000000000000000000001408 162.0
HKD2_k127_3987816_18 TIGRFAM Succinate dehydrogenase, hydrophobic membrane anchor K00242 - - 0.0000000000000000000000000000000000000476 149.0
HKD2_k127_3987816_19 Carboxymuconolactone decarboxylase family - - - 0.00000000000000000000000000000000005734 138.0
HKD2_k127_3987816_2 X-Pro dipeptidyl-peptidase (S15 family) - - - 1.425e-245 776.0
HKD2_k127_3987816_20 Acetyltransferase (GNAT) domain K00657 - 2.3.1.57 0.00000000000000000000000000000000006567 147.0
HKD2_k127_3987816_21 PIN domain - - - 0.000000000000000000000001898 110.0
HKD2_k127_3987816_22 PFAM helix-turn-helix- domain containing protein AraC type - - - 0.000000000000000000000007285 111.0
HKD2_k127_3987816_23 SnoaL-like domain - - - 0.0000000000000000000003424 104.0
HKD2_k127_3987816_24 ABC-type transport auxiliary lipoprotein component K18480 - - 0.00000000000000000001608 100.0
HKD2_k127_3987816_25 regulation of DNA-templated transcription, elongation - - - 0.000000000000000001373 93.0
HKD2_k127_3987816_26 3' exoribonuclease, RNase T-like - - - 0.000000169 63.0
HKD2_k127_3987816_3 Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily K00239 GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 5.295e-225 705.0
HKD2_k127_3987816_4 Catalyzes the reversible oxidation of malate to oxaloacetate K00024 - 1.1.1.37 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002775 531.0
HKD2_k127_3987816_5 Aminotransferase K14287 - 2.6.1.88 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001128 497.0
HKD2_k127_3987816_6 Zn_pept - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003668 453.0
HKD2_k127_3987816_7 PFAM Alcohol dehydrogenase K13953 - 1.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 441.0
HKD2_k127_3987816_8 leucine binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002465 469.0
HKD2_k127_3987816_9 GntR family K03710 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005767 351.0
HKD2_k127_3991391_0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain K03520 - 1.2.5.3 5.8e-244 775.0
HKD2_k127_3991391_1 Beta-ketoacyl synthase, C-terminal domain K09458 - 2.3.1.179 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003677 453.0
HKD2_k127_3991391_11 Phosphopantetheine attachment site K02078 - - 0.000006251 51.0
HKD2_k127_3991391_2 Bacterial transcriptional activator domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003601 444.0
HKD2_k127_3991391_3 ROK family K00847 - 2.7.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003112 381.0
HKD2_k127_3991391_4 Aerotolerance regulator N-terminal K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003233 325.0
HKD2_k127_3991391_5 protein (some members contain a von Willebrand factor type A (vWA) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002156 298.0
HKD2_k127_3991391_6 PFAM Peptidoglycan-binding domain 1 protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003831 254.0
HKD2_k127_3991391_7 pteridine-dependent deoxygenase - - - 0.000000000000000000000000000000000000000000000000000000000000005738 230.0
HKD2_k127_3995072_0 Nitronate monooxygenase K00459 - 1.13.12.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 512.0
HKD2_k127_3995072_1 Sulfatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001349 274.0
HKD2_k127_3995072_2 acyl-CoA dehydrogenase K20035 - - 0.0000009008 53.0
HKD2_k127_3995072_3 Enoyl-CoA hydratase K01692 - 4.2.1.17 0.0001674 47.0
HKD2_k127_3995072_4 Transposase zinc-binding domain - - - 0.0003881 44.0
HKD2_k127_4006146_0 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004596 309.0
HKD2_k127_4006146_1 DMT(Drug metabolite transporter) superfamily permease - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002137 271.0
HKD2_k127_4006146_2 Molybdopterin oxidoreductase Fe4S4 domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000006261 259.0
HKD2_k127_4006146_3 PFAM cytoplasmic chaperone TorD family protein - - - 0.00000000000000000001013 101.0
HKD2_k127_4020015_0 PFAM Glycosyl transferase, family 20 K00697,K16055 - 2.4.1.15,2.4.1.347,3.1.3.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002458 571.0
HKD2_k127_4020015_1 Las17-binding protein actin regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001307 252.0
HKD2_k127_4020015_2 - - - - 0.0000000000000000000000000000000000000000002157 164.0
HKD2_k127_4020015_4 gag-polyprotein putative aspartyl protease - - - 0.00000001832 56.0
HKD2_k127_4038091_0 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006241 424.0
HKD2_k127_4038091_1 PFAM Imidazoleglycerol-phosphate dehydratase K01693 - 4.2.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007342 320.0
HKD2_k127_4038091_2 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000002294 259.0
HKD2_k127_4038091_3 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR K02501 - - 0.000000000002367 70.0
HKD2_k127_4039083_0 Uncharacterized protein conserved in bacteria (DUF2252) - - - 1.358e-228 715.0
HKD2_k127_4039083_1 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003365 490.0
HKD2_k127_4039083_2 Sulfatase - - - 0.000000000000002591 76.0
HKD2_k127_4059506_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 3.814e-275 851.0
HKD2_k127_4059506_1 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005589 499.0
HKD2_k127_4086189_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0 1305.0
HKD2_k127_4086189_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 9.963e-224 700.0
HKD2_k127_4086189_2 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008976 563.0
HKD2_k127_4086189_3 Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase K03545 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007137 468.0
HKD2_k127_4086189_4 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA K06917 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 412.0
HKD2_k127_4086189_5 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 343.0
HKD2_k127_4086189_6 PFAM lipolytic protein G-D-S-L family K10804 - 3.1.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000003637 267.0
HKD2_k127_4086189_7 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K03530 - - 0.00000000000000000000000000000000000001059 146.0
HKD2_k127_4086189_8 - - - - 0.000000001255 62.0
HKD2_k127_4087265_0 Putative esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 331.0
HKD2_k127_4087265_1 Beta-lactamase superfamily domain - - - 0.000001571 61.0
HKD2_k127_4245377_0 Protein of unknown function (DUF1298) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003101 498.0
HKD2_k127_4245377_1 acyl-coA-binding protein - - - 0.000000000000000000000000000003574 138.0
HKD2_k127_4245377_2 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) - - - 0.00000000000000008424 86.0
HKD2_k127_4245377_3 Threonyl alanyl tRNA synthetase K07050 - - 0.000000000000001189 81.0
HKD2_k127_4265885_0 AMP-binding enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001464 405.0
HKD2_k127_4265885_1 Bacterial lipid A biosynthesis acyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003576 287.0
HKD2_k127_4265885_2 membrane - - - 0.00000000000000000000000000002168 127.0
HKD2_k127_4265885_3 FabA-like domain - - - 0.00000000000004492 78.0
HKD2_k127_4265885_4 Phosphopantetheine attachment site K02078 - - 0.00000000000004569 72.0
HKD2_k127_4307403_0 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455,K11745,K11747 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002892 586.0
HKD2_k127_4307403_1 pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for K15987 - 3.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000119 539.0
HKD2_k127_4307942_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.0 1079.0
HKD2_k127_4307942_1 peptidase S9A, prolyl oligopeptidase domain protein beta-propeller K01354 - 3.4.21.83 1.565e-208 672.0
HKD2_k127_4307942_10 Glutathione S-transferase, N-terminal domain K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000859 350.0
HKD2_k127_4307942_11 binding-protein-dependent transport systems inner membrane component K02053 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002117 357.0
HKD2_k127_4307942_12 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 339.0
HKD2_k127_4307942_13 Acetyltransferase (GNAT) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005716 251.0
HKD2_k127_4307942_14 LysR substrate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000006738 250.0
HKD2_k127_4307942_15 DSBA-like thioredoxin domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007358 248.0
HKD2_k127_4307942_16 Bacterial protein of unknown function (DUF882) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001241 245.0
HKD2_k127_4307942_17 Glutathione-dependent formaldehyde-activating enzyme - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003903 254.0
HKD2_k127_4307942_18 TIGRFAM Carbohydrate kinase, thermoresistant glucokinase K00851 - 2.7.1.12 0.000000000000000000000000000000000000000000000000000000001577 205.0
HKD2_k127_4307942_19 3-demethylubiquinone-9 3-methyltransferase K04750 - - 0.0000000000000000000000000000000000000000000000000000187 191.0
HKD2_k127_4307942_2 PFAM Peptidoglycan-binding domain 1 protein K21470 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002394 614.0
HKD2_k127_4307942_20 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000000000000000000000000000000313 190.0
HKD2_k127_4307942_21 Glyoxalase bleomycin resistance protein dioxygenase K06996 - - 0.00000000000000000000000000000000000000000009747 165.0
HKD2_k127_4307942_22 transcriptional regulator - - - 0.000000000000000000000000000000000000001001 170.0
HKD2_k127_4307942_23 COG2513 PEP phosphonomutase and related enzymes K03417 - 4.1.3.30 0.000000000000000000000000000000000000005826 148.0
HKD2_k127_4307942_24 Protein of unknown function (DUF3297) - - - 0.000000000000000000000000000000000004397 141.0
HKD2_k127_4307942_25 Hydroxymethylglutaryl-coenzyme A reductase - - - 0.000000000000000000000000000001095 126.0
HKD2_k127_4307942_26 Hydroxymethylglutaryl-coenzyme A reductase - - - 0.000000000000000000000000002263 114.0
HKD2_k127_4307942_27 GCN5-related N-acetyl-transferase K06975 - - 0.000000000000000000000004219 105.0
HKD2_k127_4307942_3 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K16871 - 2.6.1.96 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000054 556.0
HKD2_k127_4307942_4 Dehydrogenase K00101 - 1.1.2.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000818 549.0
HKD2_k127_4307942_5 PFAM extracellular solute-binding protein family 1 K02055 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 540.0
HKD2_k127_4307942_6 OPT oligopeptide transporter protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008764 496.0
HKD2_k127_4307942_7 Binding-protein-dependent transport system inner membrane component K02054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002506 443.0
HKD2_k127_4307942_8 6-phosphogluconate dehydrogenase K00033 - 1.1.1.343,1.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 431.0
HKD2_k127_4307942_9 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system K02052,K11076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000194 406.0
HKD2_k127_4321867_0 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003279 492.0
HKD2_k127_4321867_1 TIGRFAM decaheme c-type cytochrome, DmsE family - - - 0.0000000000001057 84.0
HKD2_k127_4349967_0 HI0933-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004407 556.0
HKD2_k127_4349967_1 GMP synthase C terminal domain K01951 - 6.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 422.0
HKD2_k127_4351265_0 Malic enzyme K00029 - 1.1.1.40 0.0 1132.0
HKD2_k127_4351265_1 Belongs to the transketolase family K00615 - 2.2.1.1 1.53e-289 904.0
HKD2_k127_4351265_10 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K00014 GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0004764,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0022414,GO:0032501,GO:0032502,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046417,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0055114,GO:0061458,GO:0071704,GO:1901576,GO:1901615 1.1.1.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001216 296.0
HKD2_k127_4351265_11 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000000000000000000000003287 269.0
HKD2_k127_4351265_12 COG0810 Periplasmic protein TonB, links inner and outer membranes K03832 - - 0.0000000000000000000000000000000000000000000000000000000000001871 223.0
HKD2_k127_4351265_13 RNB K01147 - 3.1.13.1 0.0000000000000000000000000000000000000000000000000000002217 199.0
HKD2_k127_4351265_14 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit K09761 - 2.1.1.193 0.0000000000000000000000000000000000000000000000000002812 202.0
HKD2_k127_4351265_15 Transglycosylase SLT domain - - - 0.0000000000000000000000000000000000000000000001241 179.0
HKD2_k127_4351265_16 ribonuclease K01167 - 3.1.27.3 0.00000000000000000000000000000000000001235 149.0
HKD2_k127_4351265_17 KTSC domain - - - 0.00000000000000000000000000002502 117.0
HKD2_k127_4351265_18 Bacterial protein of unknown function (DUF937) - - - 0.0000000000000000000000000002402 119.0
HKD2_k127_4351265_19 Glyoxalase-like domain - - - 0.0000000000000000000000191 105.0
HKD2_k127_4351265_2 Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis K03182 - 4.1.1.98 3.865e-271 840.0
HKD2_k127_4351265_20 Barstar (barnase inhibitor) - - - 0.00000000000000000000209 104.0
HKD2_k127_4351265_21 Rhomboid family - - - 0.000000000000000007476 99.0
HKD2_k127_4351265_3 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 9.383e-215 681.0
HKD2_k127_4351265_4 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005847 610.0
HKD2_k127_4351265_5 Acts as a magnesium transporter K06213 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 602.0
HKD2_k127_4351265_6 Belongs to the phosphoglycerate kinase family K00927 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003377 578.0
HKD2_k127_4351265_7 catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis K01624 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000638 475.0
HKD2_k127_4351265_8 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001715 467.0
HKD2_k127_4351265_9 Belongs to the peptidase S8 family K14645 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 349.0
HKD2_k127_4355313_0 Sulfatase K01130 - 3.1.6.1 2e-323 998.0
HKD2_k127_4355313_1 Iron-sulfur cluster-binding domain K06871 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003823 580.0
HKD2_k127_4355313_2 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661,K07536 - 4.1.3.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001774 510.0
HKD2_k127_4355313_3 AMP-binding enzyme C-terminal domain K01911 - 6.2.1.26 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001694 456.0
HKD2_k127_4355313_4 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000007003 261.0
HKD2_k127_4355313_5 Predicted periplasmic protein (DUF2092) - - - 0.0000000000000000000000000000000000000000000008991 176.0
HKD2_k127_4355313_6 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000006288 111.0
HKD2_k127_4359419_0 DNA polymerase K02337 - 2.7.7.7 0.0 1284.0
HKD2_k127_4359419_1 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) K01885 - 6.1.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003993 599.0
HKD2_k127_4359419_2 Major facilitator superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006663 472.0
HKD2_k127_4359419_3 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000008098 253.0
HKD2_k127_4359419_4 Glycosyl transferase family 2 - - - 0.00000000000000000002347 92.0
HKD2_k127_4359419_7 - - - - 0.00002703 46.0
HKD2_k127_4368898_0 exporter - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 387.0
HKD2_k127_4368898_1 Outer membrane lipoprotein carrier protein LolA - - - 0.00000000000000000000000000000000000000001379 159.0
HKD2_k127_4386340_0 Sulfatase K01130 - 3.1.6.1 0.0 1230.0
HKD2_k127_4391459_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 6.981e-298 935.0
HKD2_k127_4391459_1 it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins K02314 - 3.6.4.12 1.097e-220 692.0
HKD2_k127_4391459_10 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine K02502 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001802 419.0
HKD2_k127_4391459_11 3'-5' exonuclease K07501 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002019 382.0
HKD2_k127_4391459_12 HflC and HflK could regulate a protease K04087 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009498 353.0
HKD2_k127_4391459_13 ATPase related to phosphate starvation-inducible protein PhoH K07175 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009732 334.0
HKD2_k127_4391459_14 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K17713 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001181 325.0
HKD2_k127_4391459_15 RNA polymerase sigma factor RpoS K03087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001164 318.0
HKD2_k127_4391459_16 Specifically methylates the ribose of guanosine 2251 in 23S rRNA K03218 - 2.1.1.185 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002431 276.0
HKD2_k127_4391459_17 PFAM Fatty acid desaturase K00496 - 1.14.15.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000002519 275.0
HKD2_k127_4391459_18 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001102 267.0
HKD2_k127_4391459_19 phosphoribosyltransferase K07101 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001618 261.0
HKD2_k127_4391459_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 - 1.17.7.1,1.17.7.3 3.409e-212 667.0
HKD2_k127_4391459_20 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.000000000000000000000000000000000000000000000000000000000000000000000004735 245.0
HKD2_k127_4391459_21 binds to the 23S rRNA K02939 - - 0.0000000000000000000000000000000000000000000000000000000000003467 214.0
HKD2_k127_4391459_22 Protein of unknown function (DUF456) K09793 - - 0.0000000000000000000000000000000000000000000000000000000000003644 214.0
HKD2_k127_4391459_23 Tetratricopeptide repeat-like domain - - - 0.00000000000000000000000000000000000000000000000000000000008106 211.0
HKD2_k127_4391459_24 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.00000000000000000000000000000000000000000000000000000006759 197.0
HKD2_k127_4391459_25 Tetratricopeptide repeat K02656 - - 0.00000000000000000000000000000000000000000000000000000008228 205.0
HKD2_k127_4391459_26 Protein of unknown function DUF47 K07220 - - 0.0000000000000000000000000000000000000000000004498 189.0
HKD2_k127_4391459_27 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit K02963 - - 0.000000000000000000000000000000000000002697 149.0
HKD2_k127_4391459_28 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs K03666 - - 0.00000000000000000000000000000000000001199 145.0
HKD2_k127_4391459_29 Domain of unknown function (DUF4115) K15539 - - 0.000000000000000000000000004004 123.0
HKD2_k127_4391459_3 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 - 6.3.4.4 7.199e-199 631.0
HKD2_k127_4391459_30 Uncharacterized protein conserved in bacteria (DUF2065) K09937 - - 0.00000000000001803 78.0
HKD2_k127_4391459_31 peptidase K06194 - - 0.0000000000001621 70.0
HKD2_k127_4391459_32 Binds single-stranded DNA at the primosome assembly site (PAS) K02686 - - 0.000000000002893 75.0
HKD2_k127_4391459_4 GTPase that plays an essential role in the late steps of ribosome biogenesis K03977 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003298 606.0
HKD2_k127_4391459_5 Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA K03215 - 2.1.1.190 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001767 588.0
HKD2_k127_4391459_6 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs K06941 - 2.1.1.192 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 561.0
HKD2_k127_4391459_7 histidyl-tRNA synthetase K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003755 559.0
HKD2_k127_4391459_8 HflC and HflK could encode or regulate a protease K04088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002357 466.0
HKD2_k127_4391459_9 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006728 446.0
HKD2_k127_4443702_0 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 2.457e-312 963.0
HKD2_k127_4443702_1 Male sterility protein - - - 1.892e-309 960.0
HKD2_k127_4443702_10 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003408 467.0
HKD2_k127_4443702_11 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006966 443.0
HKD2_k127_4443702_12 esterase of the alpha-beta hydrolase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001388 433.0
HKD2_k127_4443702_13 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 342.0
HKD2_k127_4443702_14 Bacterial transcriptional repressor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008365 313.0
HKD2_k127_4443702_15 Belongs to the 5'-nucleotidase family K01081,K11751 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006195,GO:0006213,GO:0006259,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007155,GO:0007159,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009164,GO:0009166,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0018130,GO:0019362,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0022610,GO:0031974,GO:0031981,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042578,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046135,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0051186,GO:0055086,GO:0070013,GO:0071704,GO:0071944,GO:0072521,GO:0072523,GO:0072524,GO:0072527,GO:0072529,GO:0090304,GO:0098609,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.3.5,3.6.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000006509 292.0
HKD2_k127_4443702_16 RNA polymerase K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002441 273.0
HKD2_k127_4443702_17 ATPase MipZ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000001083 239.0
HKD2_k127_4443702_18 Haloacid dehalogenase, type II K01560 - 3.8.1.2 0.00000000000000000000000000000000000000000000000000000000000000003566 229.0
HKD2_k127_4443702_19 - - - - 0.000000000000000000000000000000000000000000000000000006557 198.0
HKD2_k127_4443702_2 Belongs to the malate synthase family K01638 - 2.3.3.9 2.568e-294 908.0
HKD2_k127_4443702_20 Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions K02553 - - 0.0000000000000000000000000000000000000000000000000151 200.0
HKD2_k127_4443702_21 PGAP1-like protein - - - 0.0000000000000000000000000000000000000008447 164.0
HKD2_k127_4443702_22 PFAM poly granule associated family protein - - - 0.00000000000000000000000000000000000005775 147.0
HKD2_k127_4443702_23 PFAM RDD domain containing protein - - - 0.000000000000000000000000002512 118.0
HKD2_k127_4443702_24 Protein of unknown function (DUF3106) - - - 0.0000000000000000000009013 105.0
HKD2_k127_4443702_25 Protein of unknown function (DUF3619) - - - 0.0000000000000002616 90.0
HKD2_k127_4443702_26 - - - - 0.0000000007791 61.0
HKD2_k127_4443702_3 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 6.619e-280 871.0
HKD2_k127_4443702_4 Isocitrate lyase K01637 - 4.1.3.1 1.794e-255 790.0
HKD2_k127_4443702_5 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 1.23e-246 777.0
HKD2_k127_4443702_6 Belongs to the ABC transporter superfamily K02031,K02032,K10823,K13896,K15583 - - 1.99e-224 709.0
HKD2_k127_4443702_7 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 7.956e-214 679.0
HKD2_k127_4443702_8 Bacterial extracellular solute-binding proteins, family 5 Middle - - - 4.432e-210 689.0
HKD2_k127_4443702_9 Binding-protein-dependent transport system inner membrane component K02034 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 473.0
HKD2_k127_4461541_0 Molybdopterin oxidoreductase Fe4S4 domain K21307 - 1.8.5.6 0.0 1264.0
HKD2_k127_4461541_1 Calcineurin-like phosphoesterase superfamily domain K07095 - - 0.000000000000000000000000000000000000000003728 158.0
HKD2_k127_4476679_0 COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000106 484.0
HKD2_k127_4476679_1 (ABC) transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005762 386.0
HKD2_k127_4476679_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001518 262.0
HKD2_k127_4476679_3 Belongs to the acetyltransferase family. ArgA subfamily K03830 - - 0.0000000000000000000000000000000000000000001177 166.0
HKD2_k127_4552682_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03046 - 2.7.7.6 0.0 1208.0
HKD2_k127_4552682_1 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit K02950 - - 0.000000000000000000000000000000000000000000000000000000000000000000005524 235.0
HKD2_k127_4552682_2 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA K02992 - - 0.000000000000000000000000000000000000000006192 154.0
HKD2_k127_4593566_0 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 - 4.1.3.27 2.132e-213 672.0
HKD2_k127_4593566_1 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) K00766 GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005729 508.0
HKD2_k127_4593566_2 Anthranilate synthase K01658 - 4.1.3.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003713 320.0
HKD2_k127_4593566_3 Acyltransferase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000388 240.0
HKD2_k127_4617089_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1593.0
HKD2_k127_4617089_1 Polyphosphate kinase 2 (PPK2) K22468 - 2.7.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004101 566.0
HKD2_k127_4617089_2 Belongs to the ABC transporter superfamily K02031 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000151 542.0
HKD2_k127_4617089_3 Oligopeptide/dipeptide transporter, C-terminal region K02032 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009731 471.0
HKD2_k127_4617089_4 COG1233 Phytoene dehydrogenase and related proteins K09516,K09835 - 1.3.99.23,5.2.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005003 412.0
HKD2_k127_4617089_5 Protein of unknown function (DUF2891) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001023 372.0
HKD2_k127_4617089_6 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000298 308.0
HKD2_k127_4617089_7 Putative auto-transporter adhesin, head GIN domain - - - 0.0000000000000000000000000000000000127 148.0
HKD2_k127_4617089_8 - - - - 0.000000000000000000000000004589 116.0
HKD2_k127_4617089_9 Psort location Cytoplasmic, score 8.96 - - - 0.0000004087 63.0
HKD2_k127_4642960_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 0.0 1389.0
HKD2_k127_4642960_1 L-serine dehydratase K01752 - 4.3.1.17 1.03e-218 691.0
HKD2_k127_4642960_2 L-carnitine dehydratase bile acid-inducible protein F - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003942 610.0
HKD2_k127_4642960_3 CDGSH-type zinc finger. Function unknown. - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001702 284.0
HKD2_k127_4642960_4 Prolyl oligopeptidase family K06889 - - 0.0000000000000000000000000000000000000000000000000000000008631 211.0
HKD2_k127_4642960_5 Pyruvate carboxyltransferase K01640 - 4.1.3.4 0.00000000000000306 80.0
HKD2_k127_4699195_0 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD K01802 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000003143 229.0
HKD2_k127_4699195_1 Belongs to the enoyl-CoA hydratase isomerase family K15866 - 5.3.3.18 0.000000000000000000000000000000000000000000000000000000003257 212.0
HKD2_k127_4699195_2 translation initiation factor activity K06996 - - 0.0000000000000000000000000000000000000000004066 169.0
HKD2_k127_4699195_3 Domain of unknown function (DUF1840) - - - 0.000000000000000006097 92.0
HKD2_k127_4815858_0 Domain of unknown function (DUF3479) K03403 - 6.6.1.1 0.0 1822.0
HKD2_k127_4815858_1 Major facilitator superfamily K08226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000126 604.0
HKD2_k127_4815858_2 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein K02588 - 1.18.6.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004583 519.0
HKD2_k127_4815858_3 Magnesium-protoporphyrin IX methyltransferase C-terminus K03428 - 2.1.1.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006163 311.0
HKD2_k127_4815858_4 Photosynthetic reaction centre, H-chain N-terminal region K13991 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004429 308.0
HKD2_k127_4815858_5 Bacterial PH domain - - - 0.000000000000000000000000000000006777 142.0
HKD2_k127_482789_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003206 577.0
HKD2_k127_482789_1 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 505.0
HKD2_k127_482789_2 His Kinase A (phosphoacceptor) domain K02484,K07645 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002067 352.0
HKD2_k127_482789_3 Transcriptional regulatory protein, C terminal K02483,K07666 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001724 317.0
HKD2_k127_482789_4 ornithine cyclodeaminase K01750 - 4.3.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000005185 271.0
HKD2_k127_482789_5 SOS response associated peptidase (SRAP) - - - 0.000000000000000000000000000000000000000000000001045 181.0
HKD2_k127_482789_6 BON domain - - - 0.000000000000000000000000000000000001793 151.0
HKD2_k127_482789_7 SNARE associated Golgi protein - - - 0.00000000000000000000000000000000002467 146.0
HKD2_k127_4844569_0 Heat shock 70 kDa protein K04043 GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - 2.446e-321 992.0
HKD2_k127_4844569_1 Catalyzes the ferrous insertion into protoporphyrin IX K01772 - 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001017 466.0
HKD2_k127_4844569_10 PFAM 4Fe-4S ferredoxin iron-sulfur binding - - - 0.000000007006 62.0
HKD2_k127_4844569_2 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006903 427.0
HKD2_k127_4844569_3 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002371 295.0
HKD2_k127_4844569_4 Domain of Unknown function (DUF542) - - - 0.0000000000000000000000000000000000000000000000000000000000000000009285 234.0
HKD2_k127_4844569_5 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 - - 0.000000000000000000000000000000000000000000000000000005325 195.0
HKD2_k127_4844569_6 sister chromatid segregation - - - 0.0000000000000000000000000000000000000000009522 168.0
HKD2_k127_4844569_7 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000001735 156.0
HKD2_k127_4844569_8 Nitrous oxide-stimulated promoter - - - 0.0000000000000000000000000000000004636 138.0
HKD2_k127_4922790_0 Bacterial pre-peptidase C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 591.0
HKD2_k127_4922790_1 Domain present in phytochromes and cGMP-specific phosphodiesterases. K01768 - 4.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 520.0
HKD2_k127_4922790_10 PFAM CDP-alcohol phosphatidyltransferase K08744 - 2.7.8.41 0.00000000000000000000000000000000000001464 151.0
HKD2_k127_4922790_11 pyridoxamine 5-phosphate - - - 0.000000000000000000000000000000501 127.0
HKD2_k127_4922790_12 Protein of unknown function (DUF1289) K06938 - - 0.0000000000000003463 79.0
HKD2_k127_4922790_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001248 442.0
HKD2_k127_4922790_3 Aldo keto - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 336.0
HKD2_k127_4922790_4 beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007873 336.0
HKD2_k127_4922790_5 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000008284 290.0
HKD2_k127_4922790_6 Neisseria PilC beta-propeller domain K02674 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005215 271.0
HKD2_k127_4922790_7 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.000000000000000000000000000000000000000000000000000000000003126 213.0
HKD2_k127_4922790_8 - - - - 0.00000000000000000000000000000000000000000000000000001092 197.0
HKD2_k127_4922790_9 Thioesterase K18700 - 3.1.2.29 0.00000000000000000000000000000000000000000000000004791 181.0
HKD2_k127_49794_0 helicase superfamily c-terminal domain K03724 - - 0.0 1063.0
HKD2_k127_49794_1 SWIB/MDM2 domain K03169 - 5.99.1.2 0.000000000000000000000000000000000000271 143.0
HKD2_k127_49794_2 - - - - 0.000000000000000000000000001857 113.0
HKD2_k127_49794_3 Belongs to the ribose-phosphate pyrophosphokinase family K00948 - 2.7.6.1 0.0000000000000000006598 89.0
HKD2_k127_49794_4 Catalyzes the sodium-dependent transport of glutamate K03312 - - 0.0000000000004037 76.0
HKD2_k127_49794_5 Alpha/beta hydrolase family - - - 0.000000002493 70.0
HKD2_k127_4989919_0 Tripartite ATP-independent periplasmic transporter, DctM component - - - 7.938e-219 697.0
HKD2_k127_4989919_1 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008076 483.0
HKD2_k127_4989919_2 TRAP-type C4-dicarboxylate transport system, small permease component - - - 0.000000000000000000000000000000000000000000000000000000000000005204 221.0
HKD2_k127_5137483_0 PFAM aldo keto reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008371 553.0
HKD2_k127_5137483_1 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006474 410.0
HKD2_k127_5137483_2 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000001882 236.0
HKD2_k127_5137483_3 - - - - 0.000000001939 64.0
HKD2_k127_5145262_0 NADH-quinone oxidoreductase K00336 - 1.6.5.3 0.0 1022.0
HKD2_k127_5145262_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 3.658e-256 792.0
HKD2_k127_5145262_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 3.707e-254 788.0
HKD2_k127_5145262_3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001595 550.0
HKD2_k127_5145262_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001314 298.0
HKD2_k127_5145262_5 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000001339 229.0
HKD2_k127_5147188_0 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 - - 1.727e-272 856.0
HKD2_k127_5147188_1 FAD dependent oxidoreductase K00313 - - 2.446e-233 726.0
HKD2_k127_5147188_10 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002509 383.0
HKD2_k127_5147188_11 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003319 357.0
HKD2_k127_5147188_12 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000006186 272.0
HKD2_k127_5147188_13 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001974 240.0
HKD2_k127_5147188_14 Iron--sulfur cluster insertion protein erpA K15724 - - 0.0000000000000000000000000000000000000000000000000007318 185.0
HKD2_k127_5147188_15 protein maturation by iron-sulfur cluster transfer K22063 GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901564 - 0.000000000000000000000000000000000000000000000000001557 186.0
HKD2_k127_5147188_16 2Fe-2S iron-sulfur cluster binding domain - - - 0.000000000000000000000000000000000000000000000000005144 189.0
HKD2_k127_5147188_17 Could be a 3Fe-4S cluster-containing protein K03855 - - 0.00000000000000000000000000000000000000000000000008635 183.0
HKD2_k127_5147188_18 Rieske-like [2Fe-2S] domain K15762 - - 0.0000000000000000000000000000000000000000000000001386 179.0
HKD2_k127_5147188_19 - - - - 0.000000000000000000000000000000000000000005533 158.0
HKD2_k127_5147188_2 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 1.44e-217 686.0
HKD2_k127_5147188_20 Glutathione S-Transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000009687 151.0
HKD2_k127_5147188_21 Ferredoxin - - - 0.0000000000000000000000000000000000000001301 152.0
HKD2_k127_5147188_22 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000002348 150.0
HKD2_k127_5147188_23 - - - - 0.000000000000000000000000000000000009418 140.0
HKD2_k127_5147188_24 May protect the nitrogenase Fe-Mo protein from oxidative damage K02595 - - 0.000000000000000000000000000000000172 135.0
HKD2_k127_5147188_25 - - - - 0.000000000000000000000001589 105.0
HKD2_k127_5147188_26 - - - - 0.00000000000000000000001465 104.0
HKD2_k127_5147188_27 - - - - 0.00000000000000002584 87.0
HKD2_k127_5147188_3 Belongs to the UPF0061 (SELO) family - - - 8.938e-211 668.0
HKD2_k127_5147188_4 Electron transfer flavoprotein domain K03522 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 599.0
HKD2_k127_5147188_5 Flavin containing amine oxidoreductase K00274 - 1.4.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 570.0
HKD2_k127_5147188_6 Belongs to the alpha-IPM synthase homocitrate synthase family K02594 - 2.3.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 513.0
HKD2_k127_5147188_7 Belongs to the AlaDH PNT family K00259 - 1.4.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008089 494.0
HKD2_k127_5147188_8 Electron transfer flavoprotein K03521 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007103 449.0
HKD2_k127_5147188_9 Fumarylacetoacetate (FAA) hydrolase family K16165 - 3.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005751 411.0
HKD2_k127_5147246_0 Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides K00997,K01207 - 2.7.8.7,3.2.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 350.0
HKD2_k127_5147246_1 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000009255 120.0
HKD2_k127_5172195_0 Forkhead associated domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000001617 241.0
HKD2_k127_5172195_1 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs K05539 GO:0000049,GO:0000166,GO:0002943,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010181,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0032553,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363 - 0.000000000000000000000000000000000000000000000000000001717 195.0
HKD2_k127_5172195_2 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 - 4.1.1.32 0.00000000000000000000000000000000000000171 149.0
HKD2_k127_5200009_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702 - - 0.0 1062.0
HKD2_k127_5200009_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 3.996e-223 699.0
HKD2_k127_5200009_10 Bacterial protein of unknown function (DUF924) - - - 0.00000000000000000000000000000000000000000000000000000000006577 211.0
HKD2_k127_5200009_11 This enzyme acetylates the N-terminal alanine of ribosomal protein S18 K03789 - 2.3.1.128 0.0000000000000000000000000000000000000126 153.0
HKD2_k127_5200009_12 Glycoprotease family K14742 - - 0.0000000000000000000000000000000000001572 151.0
HKD2_k127_5200009_2 PFAM aminotransferase class I and II K00832 - 2.6.1.57 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001413 555.0
HKD2_k127_5200009_3 PFAM major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001427 549.0
HKD2_k127_5200009_4 Phytoene synthase K02291 - 2.5.1.32,2.5.1.99 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008527 402.0
HKD2_k127_5200009_5 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids K01775 - 5.1.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003415 387.0
HKD2_k127_5200009_6 squalene synthase HpnC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 340.0
HKD2_k127_5200009_7 Flavin containing amine oxidoreductase K21677 - 1.17.8.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000825 315.0
HKD2_k127_5200009_8 TIGRFAM phage SPO1 DNA polymerase-related protein K21929 - 3.2.2.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000287 275.0
HKD2_k127_5200009_9 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K01104 GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000003613 263.0
HKD2_k127_5205443_0 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002823 537.0
HKD2_k127_5205443_1 Na h exchange protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 390.0
HKD2_k127_5205443_2 PFAM MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000973 351.0
HKD2_k127_5205443_3 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005755 354.0
HKD2_k127_5205443_4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000005052 274.0
HKD2_k127_5205443_5 Biopolymer transport protein ExbD/TolR K03559 - - 0.00000000000000000000000000000000000000000000000000000001057 201.0
HKD2_k127_5205443_6 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.00000000000000000000000000000000000000000000000000001526 194.0
HKD2_k127_5205443_7 PFAM Biopolymer transport protein ExbD TolR K03559 - - 0.00000000000000000000000000000000000000000000000001856 183.0
HKD2_k127_5205443_8 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000000000000000000000000000000000000000003403 163.0
HKD2_k127_5205443_9 Cytochrome c K17223 - - 0.00000000000000000000000000005581 119.0
HKD2_k127_5255246_0 NADH ubiquinone oxidoreductase subunit 5 (Chain L) Multisubunit Na H antiporter, MnhA subunit K00341,K05559 - 1.6.5.3 4.112e-312 981.0
HKD2_k127_5255246_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 4.687e-309 954.0
HKD2_k127_5255246_10 Belongs to the acetylglutamate kinase family. ArgB subfamily K00930 - 2.7.2.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002448 480.0
HKD2_k127_5255246_11 Formate hydrogenlyase subunit 3 Multisubunit Na H antiporter, MnhD subunit K05561 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005888 450.0
HKD2_k127_5255246_12 RNA polymerase sigma factor RpoH K03089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003638 425.0
HKD2_k127_5255246_13 cytochrome oxidase assembly K02259 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001129 421.0
HKD2_k127_5255246_14 Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group K02257 - 2.5.1.141 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004852 412.0
HKD2_k127_5255246_15 Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily K01834 - 5.4.2.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001479 402.0
HKD2_k127_5255246_16 Heme copper-type cytochrome quinol oxidase, subunit 3 K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 397.0
HKD2_k127_5255246_17 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 394.0
HKD2_k127_5255246_18 ThiF family K21029 - 2.7.7.80 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 366.0
HKD2_k127_5255246_19 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001139 343.0
HKD2_k127_5255246_2 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 - 3.3.1.1 5.579e-254 807.0
HKD2_k127_5255246_20 Bacterial lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002736 322.0
HKD2_k127_5255246_21 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery K01419 - 3.4.25.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000039 308.0
HKD2_k127_5255246_22 Belongs to the 'phage' integrase family. XerC subfamily K03733 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 316.0
HKD2_k127_5255246_23 acyltransferase K02517 - 2.3.1.241 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001063 294.0
HKD2_k127_5255246_24 cytochrome C oxidase K02258 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000207 254.0
HKD2_k127_5255246_25 Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway K02169 - 2.1.1.197 0.0000000000000000000000000000000000000000000000000000000000000000000000000219 261.0
HKD2_k127_5255246_26 Peptidase family M23 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000004998 271.0
HKD2_k127_5255246_27 PFAM regulatory protein TetR K05501 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003254 254.0
HKD2_k127_5255246_28 Electron transport protein SCO1 SenC K07152 - - 0.000000000000000000000000000000000000000000000000000000000000000000003288 239.0
HKD2_k127_5255246_29 response to antibiotic - - - 0.00000000000000000000000000000000000000000000000000000000000000000001424 251.0
HKD2_k127_5255246_3 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 - 2.5.1.6 5.312e-229 714.0
HKD2_k127_5255246_30 Haloacid dehalogenase-like hydrolase K07025 - - 0.0000000000000000000000000000000000000000000000000000000000000000001148 239.0
HKD2_k127_5255246_31 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide K03216 - 2.1.1.207 0.000000000000000000000000000000000000000000000000000000000000000004659 228.0
HKD2_k127_5255246_32 Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters K06204 - - 0.00000000000000000000000000000000000000000000000000000000000001556 226.0
HKD2_k127_5255246_33 Protein of unknown function, DUF484 K09921 - - 0.0000000000000000000000000000000000000000000000000000000000005069 217.0
HKD2_k127_5255246_34 Belongs to the LOG family K06966 - 3.2.2.10 0.000000000000000000000000000000000000000000000000000000000001089 215.0
HKD2_k127_5255246_35 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA K03071 - - 0.00000000000000000000000000000000000000000000000000000004802 203.0
HKD2_k127_5255246_36 Lysin motif - - - 0.0000000000000000000000000000000000000000000000000006926 191.0
HKD2_k127_5255246_37 signal sequence binding - - - 0.0000000000000000000000000000000000000000000000003391 190.0
HKD2_k127_5255246_38 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000001092 183.0
HKD2_k127_5255246_39 Na+/H+ ion antiporter subunit - - - 0.000000000000000000000000000000000000000000003989 175.0
HKD2_k127_5255246_4 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis K03667 - - 1.923e-204 644.0
HKD2_k127_5255246_40 Competence protein - - - 0.0000000000000000000000000000000000000000004589 166.0
HKD2_k127_5255246_41 SURF1-like protein K14998 - - 0.000000000000000000000000000000000000000003486 164.0
HKD2_k127_5255246_42 Copper chaperone PCu(A)C K09796 - - 0.000000000000000000000000000000000000000234 155.0
HKD2_k127_5255246_43 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins K03676 - - 0.000000000000000000000000000000000000003644 147.0
HKD2_k127_5255246_44 oxidoreductase, chain 4L K05560 - - 0.000000000000000000000000000000003486 142.0
HKD2_k127_5255246_45 PFAM Rhodanese domain protein K01011 - 2.8.1.1,2.8.1.2 0.000000000000000000000000000001024 127.0
HKD2_k127_5255246_46 COG1320 Multisubunit Na H antiporter, MnhG subunit K05564 - - 0.00000000000000000000000000001393 126.0
HKD2_k127_5255246_47 Integral membrane protein (DUF2244) - - - 0.000000000000000000000000002537 117.0
HKD2_k127_5255246_48 PFAM multiple resistance and pH regulation protein F K05563 - - 0.000000000000000000000000008014 113.0
HKD2_k127_5255246_49 Protein of unknown function (DUF2970) - - - 0.0000000000000000001345 91.0
HKD2_k127_5255246_5 Peptidase family S49 K04773 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002494 609.0
HKD2_k127_5255246_50 Protein of unknown function (DUF2909) - - - 0.0000000000000000009571 98.0
HKD2_k127_5255246_51 mercury ion transmembrane transporter activity - - - 0.00000386 51.0
HKD2_k127_5255246_52 - - - - 0.00001942 54.0
HKD2_k127_5255246_6 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005871 564.0
HKD2_k127_5255246_7 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002232 516.0
HKD2_k127_5255246_8 Cobalamin biosynthesis protein CobW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007386 509.0
HKD2_k127_5255246_9 S-adenosylmethionine-dependent methyltransferase K06969 - 2.1.1.191 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 505.0
HKD2_k127_5274781_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002663 549.0
HKD2_k127_5274781_1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002043 413.0
HKD2_k127_5274781_2 Yqey-like protein K09117 - - 0.0000000000000000000000000000000000000000000000003153 183.0
HKD2_k127_5274781_3 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 - 2.3.1.234 0.000000000000000000000000000000000000000000000262 169.0
HKD2_k127_5274781_4 Ribosomal protein S21 K02970 - - 0.000000000000000000000000000000007439 127.0
HKD2_k127_5302102_0 Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers K07518 - 3.1.1.22 4.046e-214 688.0
HKD2_k127_5302102_1 Type II secretory pathway, component ExeA K02450 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002116 593.0
HKD2_k127_5302102_2 PFAM regulatory protein LysR - - - 0.00000000000000000000000000000000000000000000000000000000000000000006159 240.0
HKD2_k127_5302102_3 Type II secretion system protein B K02451 - - 0.0000000003245 65.0
HKD2_k127_5305124_0 Adenylate cyclase - - - 2.307e-224 714.0
HKD2_k127_5305124_1 Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers K07518 - 3.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002445 469.0
HKD2_k127_5305124_10 Prokaryotic cytochrome b561 - - - 0.00000000000000000000000000000009084 132.0
HKD2_k127_5305124_11 Protein conserved in bacteria - - - 0.0000000000000000000003099 102.0
HKD2_k127_5305124_2 Methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001154 403.0
HKD2_k127_5305124_3 PFAM Short-chain dehydrogenase reductase SDR - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002655 246.0
HKD2_k127_5305124_4 glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000000000001613 207.0
HKD2_k127_5305124_5 CHRD domain - - - 0.000000000000000000000000000000000000000000000000000000000468 215.0
HKD2_k127_5305124_6 Universal stress protein family - - - 0.000000000000000000000000000000000000000000000000000000003389 207.0
HKD2_k127_5305124_7 Flavodoxin domain K00230 GO:0000166,GO:0003674,GO:0003824,GO:0004729,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0032553,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0042168,GO:0042440,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070818,GO:0070819,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.5.3 0.000000000000000000000000000000000000000000000000007206 187.0
HKD2_k127_5305124_8 OsmC-like protein - - - 0.000000000000000000000000000000000000000000002392 168.0
HKD2_k127_5305124_9 Cupin 2, conserved barrel domain protein - - - 0.00000000000000000000000000000000000001093 150.0
HKD2_k127_5308456_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.0 1405.0
HKD2_k127_5308456_1 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 5.649e-287 887.0
HKD2_k127_5308456_10 Type II transport protein GspH K08084 - - 0.0000000000000002066 87.0
HKD2_k127_5308456_11 TIGRFAM type IV pilus modification protein PilV K02671 - - 0.00000000000001854 81.0
HKD2_k127_5308456_12 type iv pilus assembly protein K02672 - - 0.00000000000005592 83.0
HKD2_k127_5308456_13 COG4968 Tfp pilus assembly protein PilE K02655 - - 0.00000000000008337 79.0
HKD2_k127_5308456_14 Belongs to the ompA family K03286 - - 0.00000000000037 76.0
HKD2_k127_5308456_15 Pilus assembly protein PilX K02673 - - 0.00006266 55.0
HKD2_k127_5308456_2 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817 - 2.6.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003484 519.0
HKD2_k127_5308456_3 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 - 2.5.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 512.0
HKD2_k127_5308456_4 Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine K12960 - 3.5.4.28,3.5.4.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 500.0
HKD2_k127_5308456_5 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001915 487.0
HKD2_k127_5308456_6 TIGRFAM chorismate mutase domain of proteobacterial P-protein, clade 2 K01713,K14170 - 4.2.1.51,4.2.1.91,5.4.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006581 453.0
HKD2_k127_5308456_7 Neisseria PilC beta-propeller domain K02674 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000292 419.0
HKD2_k127_5308456_8 Belongs to the cytidylate kinase family. Type 1 subfamily K00945 - 2.7.4.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000001017 268.0
HKD2_k127_5308456_9 prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000001702 264.0
HKD2_k127_5309993_0 FtsX-like permease family K02004 - - 2.508e-281 887.0
HKD2_k127_5309993_1 Bacterial-like globin K06886 - - 0.0000000000000000000000000000000000000000000000000000003719 196.0
HKD2_k127_5309993_3 Domain of unknown function (DUF4139) - - - 0.0001872 48.0
HKD2_k127_5334411_0 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000009959 250.0
HKD2_k127_5334411_1 Tfp pilus assembly protein tip-associated adhesin K02674 - - 0.000000005495 66.0
HKD2_k127_5363126_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 582.0
HKD2_k127_5363126_1 Putative sensor - - - 0.00000000000000000000000000000000000000000000000000000000001028 217.0
HKD2_k127_5363126_2 PadR family transcriptional regulator K10947 - - 0.0000000000000000000000000000000001654 137.0
HKD2_k127_5363126_3 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000005323 134.0
HKD2_k127_5363126_4 Late embryogenesis abundant protein - - - 0.00000000000001416 87.0
HKD2_k127_5398251_0 ABC transporter K02056 - 3.6.3.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007699 577.0
HKD2_k127_5398251_2 - - - - 0.0000000000000000000004056 100.0
HKD2_k127_5398251_3 Branched-chain amino acid transport system / permease component K02057 - - 0.000000000000000004379 88.0
HKD2_k127_5401519_0 3-hydroxyacyl-coa dehydrogenase K07516 - 1.1.1.35 0.0 1148.0
HKD2_k127_5401519_1 ABC transporter transmembrane region K06147 - - 3.462e-257 809.0
HKD2_k127_5401519_10 FAD dependent oxidoreductase K00244 - 1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000365 379.0
HKD2_k127_5401519_11 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009083 320.0
HKD2_k127_5401519_12 PFAM Enoyl-CoA hydratase isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001914 316.0
HKD2_k127_5401519_13 Amino acid ABC transporter substrate-binding protein K10001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003081 317.0
HKD2_k127_5401519_14 hydroxypyruvate reductase K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002888 310.0
HKD2_k127_5401519_15 Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008021 312.0
HKD2_k127_5401519_16 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009838 293.0
HKD2_k127_5401519_17 Acyl-CoA hydrolase K10806 - - 0.00000000000000000000000000000000000000000000000000000004058 200.0
HKD2_k127_5401519_18 Thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000005467 178.0
HKD2_k127_5401519_19 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000007774 158.0
HKD2_k127_5401519_2 Belongs to the thiolase family K00632 - 2.3.1.16 8.98e-198 622.0
HKD2_k127_5401519_20 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000000000000000000000000000000000001897 162.0
HKD2_k127_5401519_21 Limonene-1,2-epoxide hydrolase catalytic domain - - - 0.000000000000000000000000000009311 125.0
HKD2_k127_5401519_3 O-methyltransferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005653 593.0
HKD2_k127_5401519_4 extracellular solute-binding protein, family 3 K02030,K09969,K10001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003588 543.0
HKD2_k127_5401519_5 TIGRFAM polar amino acid ABC transporter, inner membrane subunit K09971 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001028 544.0
HKD2_k127_5401519_6 PFAM ABC transporter related K02028,K09972 - 3.6.3.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 439.0
HKD2_k127_5401519_7 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004045 439.0
HKD2_k127_5401519_8 Enoyl-(Acyl carrier protein) reductase K13775 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001304 396.0
HKD2_k127_5401519_9 acid transport system permease K09970 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000136 386.0
HKD2_k127_5419854_0 Imidazolone-5-propionate hydrolase K01468 - 3.5.2.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005513 589.0
HKD2_k127_5419854_1 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase K03885 - 1.6.99.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001124 492.0
HKD2_k127_5419854_2 Catalyzes the conversion of N-formimidoyl-L-glutamate to L-glutamate and formamide K01479 - 3.5.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000378 384.0
HKD2_k127_5419854_3 Histidine ammonia-lyase K01745 - 4.3.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003379 354.0
HKD2_k127_5419854_4 DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase K14162 - 2.7.7.7 0.0000000000000000000000000000000000000002356 154.0
HKD2_k127_5434811_0 MotA TolQ ExbB proton channel K03561 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006661 407.0
HKD2_k127_5434811_1 Periplasmic protein TonB, links inner and outer membranes K03832 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001481 253.0
HKD2_k127_5452494_0 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0 1348.0
HKD2_k127_5452494_1 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 2.474e-299 924.0
HKD2_k127_5452494_10 PFAM Citrate transporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004453 443.0
HKD2_k127_5452494_11 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) K01714 - 4.3.3.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002187 416.0
HKD2_k127_5452494_12 Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor K00254 - 1.3.5.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 414.0
HKD2_k127_5452494_13 Cysteine-rich domain K18928 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003538 390.0
HKD2_k127_5452494_14 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 - 2.3.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006905 386.0
HKD2_k127_5452494_15 COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family K01092 - 3.1.3.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002762 382.0
HKD2_k127_5452494_16 helix_turn_helix isocitrate lyase regulation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009894 392.0
HKD2_k127_5452494_17 Serine aminopeptidase, S33 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 376.0
HKD2_k127_5452494_18 Bacterial transferase hexapeptide (six repeats) K00640 - 2.3.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000164 357.0
HKD2_k127_5452494_19 A domain family that is part of the cupin metalloenzyme superfamily. K18850 - 1.14.11.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002004 374.0
HKD2_k127_5452494_2 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 - - 2.505e-289 912.0
HKD2_k127_5452494_20 NlpB/DapX lipoprotein K07287 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 348.0
HKD2_k127_5452494_21 DNA polymerase alpha chain like domain K07053 GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657 3.1.3.97 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002538 334.0
HKD2_k127_5452494_22 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002868 329.0
HKD2_k127_5452494_23 Protein of unknown function (DUF455) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004743 316.0
HKD2_k127_5452494_24 Belongs to the peptidase S11 family K07262 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005365 316.0
HKD2_k127_5452494_25 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine K00684 - 2.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 305.0
HKD2_k127_5452494_26 glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001743 300.0
HKD2_k127_5452494_27 Belongs to the SUA5 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 291.0
HKD2_k127_5452494_28 Peptidase M50 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001095 286.0
HKD2_k127_5452494_29 Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K03269 - 3.6.1.54 0.0000000000000000000000000000000000000000000000000000000000000000000000000004005 273.0
HKD2_k127_5452494_3 AMP-binding enzyme C-terminal domain K01895 - 6.2.1.1 4.432e-255 796.0
HKD2_k127_5452494_30 Belongs to the Nudix hydrolase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000005374 263.0
HKD2_k127_5452494_31 beta-lactamase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000137 261.0
HKD2_k127_5452494_32 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767,K03768 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000001628 245.0
HKD2_k127_5452494_33 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001313 248.0
HKD2_k127_5452494_34 SpoU rRNA Methylase family K02533 - - 0.000000000000000000000000000000000000000000000000000000000000000000007032 242.0
HKD2_k127_5452494_35 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03768 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000002065 240.0
HKD2_k127_5452494_36 Tellurite resistance protein TehB - - - 0.000000000000000000000000000000000000000000000005277 181.0
HKD2_k127_5452494_37 PEP-CTERM motif - - - 0.00000000000000000000000000000000000000000000001842 183.0
HKD2_k127_5452494_38 Domain of unknown function (DUF1330) - - - 0.00000000000000000000000000000000000000000001207 164.0
HKD2_k127_5452494_39 peptidyl-prolyl K03775 - 5.2.1.8 0.0000000000000000000000000000000000000000652 158.0
HKD2_k127_5452494_4 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 2.325e-237 739.0
HKD2_k127_5452494_40 Universal stress protein - - - 0.0000000000000000000000000000000000000001224 155.0
HKD2_k127_5452494_41 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000001013 155.0
HKD2_k127_5452494_42 Outer membrane protein beta-barrel domain - - - 0.000000000000000000000000000000000000601 156.0
HKD2_k127_5452494_43 MaoC like domain - - - 0.000000000000000000000000000000000003255 142.0
HKD2_k127_5452494_44 Universal stress protein - - - 0.00000000000000000000000000000007581 130.0
HKD2_k127_5452494_45 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase K01247 - 3.2.2.21 0.0000000000000000000000000001146 118.0
HKD2_k127_5452494_46 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K05589 - - 0.0000000000000000000000008436 106.0
HKD2_k127_5452494_47 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0008452,GO:0008664,GO:0016787,GO:0016788,GO:0016874,GO:0016886,GO:0042578,GO:0140098 3.1.4.58 0.00000000000000009862 89.0
HKD2_k127_5452494_48 - - - - 0.0000000006823 72.0
HKD2_k127_5452494_5 LUD domain K18929 - - 2.01e-224 711.0
HKD2_k127_5452494_50 - - - - 0.000006198 55.0
HKD2_k127_5452494_6 Tryptophanyl-tRNA synthetase K01867 - 6.1.1.2 1.579e-206 652.0
HKD2_k127_5452494_7 Homoserine dehydrogenase, NAD binding domain-containing protein - - - 1.591e-197 623.0
HKD2_k127_5452494_8 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001898 612.0
HKD2_k127_5452494_9 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase K01627 - 2.5.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006004 485.0
HKD2_k127_5473233_0 Belongs to the ATCase OTCase family K00609 - 2.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002197 512.0
HKD2_k127_5473233_1 dihydroorotase multifunctional complex type K01465 - 3.5.2.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001764 523.0
HKD2_k127_5473233_2 UTP-glucose-1-phosphate uridylyltransferase K00963 - 2.7.7.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 394.0
HKD2_k127_5473233_3 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002753 323.0
HKD2_k127_5473233_4 Belongs to the UPF0301 (AlgH) family K07735 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001954 257.0
HKD2_k127_5473233_5 Belongs to the DNA photolyase family K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000001376 214.0
HKD2_k127_5473233_6 Phosphoribosyl transferase domain K02825 - 2.4.2.9 0.0000000000000000000000000000000000000000000000000001611 192.0
HKD2_k127_5473233_7 Acyltransferase K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000001283 194.0
HKD2_k127_5473233_8 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.0000000000000000000000000000000003818 138.0
HKD2_k127_5473233_9 Glycosyl transferase, family 4 K02851 - 2.7.8.33,2.7.8.35 0.000000000000000000000000000000004207 133.0
HKD2_k127_5483921_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002418 431.0
HKD2_k127_5483921_1 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 396.0
HKD2_k127_5483921_2 Repeat of Unknown Function (DUF347) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 319.0
HKD2_k127_5520684_0 Two-component sensor kinase N-terminal K07649 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007616 387.0
HKD2_k127_5520684_1 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004868 281.0
HKD2_k127_5520684_2 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000001589 257.0
HKD2_k127_5520684_3 Transcriptional regulatory protein, C terminal K02483 - - 0.00000000000000000000000000000000000000000000000000000004873 204.0
HKD2_k127_5520684_4 - - - - 0.0000000000000000000000000003859 126.0
HKD2_k127_5520684_5 Bacterial protein of unknown function (Gcw_chp) - - - 0.00000000000000000003531 100.0
HKD2_k127_5520684_6 Domain of unknown function (DUF4252) - - - 0.0001803 47.0
HKD2_k127_5521679_0 Subtilase family - - - 4.714e-254 799.0
HKD2_k127_5551539_0 Belongs to the CarB family K01955 - 6.3.5.5 0.0 1701.0
HKD2_k127_5551539_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0030163,GO:0042623,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - 0.0 1020.0
HKD2_k127_5551539_10 NMT1-like family K02051 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003262 507.0
HKD2_k127_5551539_11 Pyridoxal-phosphate dependent enzyme K12339 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008477 499.0
HKD2_k127_5551539_12 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001108 493.0
HKD2_k127_5551539_13 PFAM ABC transporter related K02049 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005972 469.0
HKD2_k127_5551539_14 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000431 467.0
HKD2_k127_5551539_15 Binding-protein-dependent transport system inner membrane component K02050 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001015 457.0
HKD2_k127_5551539_16 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002857 451.0
HKD2_k127_5551539_17 Domain of unknown function (DUF3329) K07636 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004471 434.0
HKD2_k127_5551539_18 Phosphate transport system permease K02038 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003533 419.0
HKD2_k127_5551539_19 glycosyl transferase group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001215 416.0
HKD2_k127_5551539_2 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 4.95e-286 889.0
HKD2_k127_5551539_20 glycosyl transferase family 2 K00721 - 2.4.1.83 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001775 424.0
HKD2_k127_5551539_21 PD-(D/E)XK nuclease superfamily K16899 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003846 426.0
HKD2_k127_5551539_22 PFAM metallophosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002406 396.0
HKD2_k127_5551539_23 MatE K03327 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004381 401.0
HKD2_k127_5551539_24 Peptidase family M48 K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001117 391.0
HKD2_k127_5551539_25 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009132 400.0
HKD2_k127_5551539_26 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001839 387.0
HKD2_k127_5551539_27 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway K00616 GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744 2.2.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002743 374.0
HKD2_k127_5551539_28 Dolichyl-phosphate-mannose-protein mannosyltransferase K19302 - 3.6.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004324 330.0
HKD2_k127_5551539_29 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796 - 2.5.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 324.0
HKD2_k127_5551539_3 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 1.352e-247 768.0
HKD2_k127_5551539_30 thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence K02945 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007322 299.0
HKD2_k127_5551539_31 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit K02427 - 2.1.1.166 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002096 284.0
HKD2_k127_5551539_32 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005084 279.0
HKD2_k127_5551539_33 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K07657 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002178 279.0
HKD2_k127_5551539_34 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO K06187 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003673 272.0
HKD2_k127_5551539_35 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002745 263.0
HKD2_k127_5551539_36 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004658 256.0
HKD2_k127_5551539_37 Ion transport protein K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000006694 238.0
HKD2_k127_5551539_38 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides K03624 - - 0.000000000000000000000000000000000000000000000000000000000000001251 224.0
HKD2_k127_5551539_39 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000000000003795 212.0
HKD2_k127_5551539_4 A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA K03582,K16898 - 3.1.11.5,3.6.4.12 3.186e-227 747.0
HKD2_k127_5551539_40 PFAM Rhomboid family protein - - - 0.0000000000000000000000000000000000000000000000000000001856 214.0
HKD2_k127_5551539_41 Belongs to the thioredoxin family K03671 - - 0.0000000000000000000000000000000000000000000000000004332 185.0
HKD2_k127_5551539_42 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection K09747 - - 0.0000000000000000000000000000000000000000005479 176.0
HKD2_k127_5551539_43 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control K05788 - - 0.00000000000000000000000000000000000000001236 155.0
HKD2_k127_5551539_44 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000000000000000000000000000000001078 163.0
HKD2_k127_5551539_45 MAPEG family - - - 0.00000000000000000000000000000000001518 142.0
HKD2_k127_5551539_46 there appears to be two types of ribosomal proteins L31 in bacterial genomes K02909 - - 0.0000000000000000000000000000000009077 135.0
HKD2_k127_5551539_47 CRS1_YhbY K07574 - - 0.00000000000000000000000000005343 123.0
HKD2_k127_5551539_48 - - - - 0.00000000001892 67.0
HKD2_k127_5551539_49 Lipopolysaccharide assembly protein A domain K08992 - - 0.00000002714 61.0
HKD2_k127_5551539_5 acyl-CoA transferases carnitine dehydratase K07749 - 2.8.3.16 2.714e-200 629.0
HKD2_k127_5551539_50 - - - - 0.0000002405 55.0
HKD2_k127_5551539_51 Belongs to the peptidase M12A family - - - 0.0000007424 56.0
HKD2_k127_5551539_52 D-galactarate dehydratase Altronate hydrolase K01708,K16846 - 4.2.1.42,4.4.1.24 0.00001723 55.0
HKD2_k127_5551539_6 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009521 616.0
HKD2_k127_5551539_7 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003686 592.0
HKD2_k127_5551539_8 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009835 562.0
HKD2_k127_5551539_9 Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001322 556.0
HKD2_k127_5571199_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 3.038e-298 940.0
HKD2_k127_5571199_1 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 8.011e-263 820.0
HKD2_k127_5571199_10 Gram-negative porin - - - 0.000000000000000000000000000000000000000000000001317 190.0
HKD2_k127_5571199_11 nucleotidyltransferase activity - - - 0.00000000000000003682 89.0
HKD2_k127_5571199_12 - - - - 0.0000000000000001161 87.0
HKD2_k127_5571199_13 Dienelactone hydrolase - - - 0.000000005354 66.0
HKD2_k127_5571199_14 pathogenesis - - - 0.000004756 56.0
HKD2_k127_5571199_15 - - - - 0.0005617 48.0
HKD2_k127_5571199_2 amidohydrolase K01451 - 3.5.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004026 576.0
HKD2_k127_5571199_3 Belongs to the peptidase M20A family. ArgE subfamily K01438 - 3.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002577 436.0
HKD2_k127_5571199_4 Putative aminopeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001393 380.0
HKD2_k127_5571199_5 coenzyme F390 synthetase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000124 379.0
HKD2_k127_5571199_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009005 362.0
HKD2_k127_5571199_7 Predicted membrane protein (DUF2238) K08984 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002592 295.0
HKD2_k127_5571199_8 COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000002022 238.0
HKD2_k127_5571199_9 depolymerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000002706 243.0
HKD2_k127_5577019_0 DEAD/DEAH box helicase K11927 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002884 550.0
HKD2_k127_5577019_1 Domain of unknown function (DUF3488) K22452 - 2.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 550.0
HKD2_k127_5577019_10 Protein of unknown function DUF58 - - - 0.00000000000000000000000000000000000000000000000000000000000000000003238 256.0
HKD2_k127_5577019_11 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000001179 89.0
HKD2_k127_5577019_12 PFAM histone deacetylase superfamily - - - 0.00000000000003794 74.0
HKD2_k127_5577019_2 ABC-type Fe3 transport system, permease component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003257 529.0
HKD2_k127_5577019_3 Belongs to the ABC transporter superfamily K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 490.0
HKD2_k127_5577019_4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002404 467.0
HKD2_k127_5577019_5 ATPase family associated with various cellular activities (AAA) K03924 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000905 419.0
HKD2_k127_5577019_6 Bacterial extracellular solute-binding protein, family 7 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004659 416.0
HKD2_k127_5577019_7 fumarylacetoacetate (FAA) hydrolase K16165 - 3.7.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001677 344.0
HKD2_k127_5577019_8 TIGRFAM maleylacetoacetate isomerase K01800,K01801 - 5.2.1.2,5.2.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003916 301.0
HKD2_k127_5577019_9 lytic murein transglycosylase K08305 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001873 272.0
HKD2_k127_5594806_0 His Kinase A (phosphoacceptor) domain K07641,K10819 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001284 411.0
HKD2_k127_5594806_1 Protein of unknown function (DUF1302) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 321.0
HKD2_k127_5594806_2 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003617 294.0
HKD2_k127_5594806_3 Two component transcriptional regulator, winged helix family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001181 263.0
HKD2_k127_5617508_0 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - - 3.453e-296 922.0
HKD2_k127_5617508_1 Peptidase C39 family K13409 - - 2.268e-198 639.0
HKD2_k127_5617508_2 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 K01086,K03841 - 3.1.3.11,3.1.3.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001636 583.0
HKD2_k127_5617508_3 Phosphoribulokinase K00855 - 2.7.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002995 499.0
HKD2_k127_5617508_4 ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001205 460.0
HKD2_k127_5617508_5 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001269 261.0
HKD2_k127_5617508_6 HlyD family secretion protein K13408 - - 0.00000000000000000000000000000000000000000000000000000000000000000000009072 255.0
HKD2_k127_5617508_7 PFAM ribulose bisphosphate carboxylase small chain K01602 - 4.1.1.39 0.00000000000000000000000000000000000000000000000000000000000006683 218.0
HKD2_k127_5617508_8 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site K01601 - 4.1.1.39 0.00000000000000000000000001562 108.0
HKD2_k127_5624994_0 Cation transport ATPase (P-type) K01537 - 3.6.3.8 1.917e-273 866.0
HKD2_k127_5624994_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001174 399.0
HKD2_k127_5624994_2 Putative neutral zinc metallopeptidase K07054 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003581 342.0
HKD2_k127_5624994_3 Ring hydroxylating alpha subunit (catalytic domain) K00499 - 1.14.15.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001891 327.0
HKD2_k127_5624994_4 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002683 314.0
HKD2_k127_5624994_5 PFAM NAD-dependent epimerase dehydratase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003324 297.0
HKD2_k127_5624994_6 serine threonine protein kinase - - - 0.0000000000000000000000000000000000000000000000000000000000003735 218.0
HKD2_k127_5624994_7 Phospholipid methyltransferase - - - 0.0000000000000000000000000000000000006007 149.0
HKD2_k127_5624994_8 LTXXQ motif family protein - - - 0.0000000000000001584 87.0
HKD2_k127_5624994_9 - - - - 0.000541 51.0
HKD2_k127_5659998_0 Methionine biosynthesis protein MetW - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001622 422.0
HKD2_k127_5659998_1 Cupin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001663 285.0
HKD2_k127_5659998_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000136 81.0
HKD2_k127_5670009_0 COG1018 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 K02613 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007166 485.0
HKD2_k127_5670009_1 Phenylacetic acid catabolic protein K02611 - 1.14.13.149 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009226 370.0
HKD2_k127_5670009_2 Beta-ketoacyl synthase, N-terminal domain K00626,K00632,K07823 - 2.3.1.16,2.3.1.174,2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000003255 275.0
HKD2_k127_5670009_3 Pfam:DUF59 K02612 - - 0.0000000000000000000000000000000000000000000000000000000000000000000152 235.0
HKD2_k127_5670009_4 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000000000000000000000000000000000003656 209.0
HKD2_k127_573325_0 methylmalonate-semialdehyde dehydrogenase K00140 - 1.2.1.18,1.2.1.27 3.988e-242 756.0
HKD2_k127_573325_1 Vault protein inter-alpha-trypsin domain - - - 2.976e-217 693.0
HKD2_k127_573325_10 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000295 504.0
HKD2_k127_573325_11 Memo-like protein K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005275 508.0
HKD2_k127_573325_12 PFAM ATP-binding region, ATPase domain protein K07641 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001178 446.0
HKD2_k127_573325_13 Belongs to the prokaryotic GSH synthase family K01920 - 6.3.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003631 379.0
HKD2_k127_573325_14 Arabinose-binding domain of AraC transcription regulator, N-term - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002047 341.0
HKD2_k127_573325_15 NHase catalyzes the hydration of various nitrile compounds to the corresponding amides K20807 - 4.2.1.84 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004817 312.0
HKD2_k127_573325_16 Nitrile hydratase, alpha chain K01721 - 4.2.1.84 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005226 289.0
HKD2_k127_573325_17 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001029 315.0
HKD2_k127_573325_18 Transcriptional regulatory protein, C terminal K07663 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002167 273.0
HKD2_k127_573325_19 PFAM glycosyl transferase family 51 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007684 260.0
HKD2_k127_573325_2 ammonium transporter K03320 - - 9.956e-212 670.0
HKD2_k127_573325_20 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000000000000004928 228.0
HKD2_k127_573325_21 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000008357 226.0
HKD2_k127_573325_22 Belongs to the P(II) protein family K04752 - - 0.0000000000000000000000000000000000000000000000000000000000001234 213.0
HKD2_k127_573325_23 Bacterial protein of unknown function (Gcw_chp) - - - 0.000000000000000000000000000000000000000000000000000003575 201.0
HKD2_k127_573325_24 Transmembrane exosortase (Exosortase_EpsH) - - - 0.0000000000000000000000000000000000000000000000000001249 197.0
HKD2_k127_573325_25 PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - 0.00000000000000000000000000000000000000000000000000288 184.0
HKD2_k127_573325_26 response regulator - - - 0.00000000000000000000000000000000000000000000000005859 186.0
HKD2_k127_573325_27 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000585 191.0
HKD2_k127_573325_28 - - - - 0.000000000000000000000000000000000000000001977 163.0
HKD2_k127_573325_29 - - - - 0.000000000000000000000000000000000000104 147.0
HKD2_k127_573325_3 Magnesium chelatase, subunit ChlI C-terminal K07391 - - 2.583e-210 665.0
HKD2_k127_573325_30 pts system fructose subfamily IIa component K02821 - 2.7.1.194 0.00000000000000000000000000000000001032 145.0
HKD2_k127_573325_31 - - - - 0.00000000000000000005051 93.0
HKD2_k127_573325_32 - - - - 0.00000000000000000006829 100.0
HKD2_k127_573325_33 Membrane fusogenic activity K09806 - - 0.000000000000000002767 93.0
HKD2_k127_573325_34 Domain of unknown function (DUF1840) - - - 0.0000000000000006154 87.0
HKD2_k127_573325_35 TIGRFAM phosphocarrier, HPr family K11189 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000009873 82.0
HKD2_k127_573325_4 Glutamate-cysteine ligase K01919 - 6.3.2.2 4.569e-201 636.0
HKD2_k127_573325_5 surface antigen variable number repeat protein K07001 - - 8.601e-201 649.0
HKD2_k127_573325_6 Radical SAM superfamily K04069 - 1.97.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001729 591.0
HKD2_k127_573325_7 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00822 - 2.6.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001357 579.0
HKD2_k127_573325_8 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002391 579.0
HKD2_k127_573325_9 Protein of unknown function (DUF1214) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003063 552.0
HKD2_k127_5787172_0 Thioredoxin - - - 0.000000000000000000000000000000000000000000004806 172.0
HKD2_k127_5787172_1 Membrane - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000001453 162.0
HKD2_k127_5787172_2 - - - - 0.00000000001466 76.0
HKD2_k127_5787172_3 - - - - 0.00000000002526 72.0
HKD2_k127_5795947_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - - 0.0 1564.0
HKD2_k127_5795947_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0 1260.0
HKD2_k127_5795947_10 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003128 473.0
HKD2_k127_5795947_11 PEP-CTERM motif - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 453.0
HKD2_k127_5795947_12 Serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001157 417.0
HKD2_k127_5795947_13 dihydroorotate dehydrogenase activity K00226 - 1.3.98.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006699 372.0
HKD2_k127_5795947_14 major facilitator superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001379 327.0
HKD2_k127_5795947_15 TIGRFAM glutamate synthase (NADPH), homotetrameric K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003385 310.0
HKD2_k127_5795947_16 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009085 304.0
HKD2_k127_5795947_17 fumarate reductase respiratory complex transmembrane subunit K00246 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001292 305.0
HKD2_k127_5795947_18 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K02573 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009653 297.0
HKD2_k127_5795947_19 TIGRFAM NADH-quinone oxidoreductase, E subunit K00334 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000003067 239.0
HKD2_k127_5795947_2 PFAM Malic enzyme, NAD binding domain K00029 - 1.1.1.40 2.387e-269 838.0
HKD2_k127_5795947_20 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000503 210.0
HKD2_k127_5795947_21 NADH dehydrogenase (ubiquinone) activity K00330 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 0.0000000000000000000000000000000000000000001431 166.0
HKD2_k127_5795947_22 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 - 1.6.5.3 0.00000000000000000000000000000000000000007051 158.0
HKD2_k127_5795947_23 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000001312 121.0
HKD2_k127_5795947_24 ferredoxin - - - 0.00000000000000000000000000008061 128.0
HKD2_k127_5795947_3 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus K00341 - 1.6.5.3 9.03e-269 839.0
HKD2_k127_5795947_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00333 - 1.6.5.3 3.113e-236 734.0
HKD2_k127_5795947_5 TIGRFAM NADH-quinone oxidoreductase, chain G K00336 - 1.6.5.3 9.791e-212 672.0
HKD2_k127_5795947_6 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region K00335 - 1.6.5.3 1.495e-209 658.0
HKD2_k127_5795947_7 Fumarate reductase flavoprotein C-term K00244 - 1.3.5.4 3.135e-197 622.0
HKD2_k127_5795947_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001549 578.0
HKD2_k127_5795947_9 NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002525 499.0
HKD2_k127_5824923_0 metal-dependent hydrolase with the TIM-barrel fold - - - 7.455e-243 764.0
HKD2_k127_5824923_1 Cys/Met metabolism PLP-dependent enzyme K01739,K01758,K01760,K01761 - 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003252 603.0
HKD2_k127_5824923_2 Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004472 547.0
HKD2_k127_5824923_3 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 539.0
HKD2_k127_5824923_4 Nad-dependent epimerase dehydratase K22025 - 1.1.1.410 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009641 373.0
HKD2_k127_5824923_5 Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00163 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001172 366.0
HKD2_k127_5824923_6 Protein of unknown function (DUF3025) - - - 0.00000000000000000000000000000000000000000000000000000000003383 228.0
HKD2_k127_5824923_7 AsnC family transcriptional regulator K03719 - - 0.000000000000000000000000000000000000000000000000001607 188.0
HKD2_k127_5824923_8 peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.000000000000000000000000000000000000000000000000003223 191.0
HKD2_k127_5824923_9 - - - - 0.000000000004838 70.0
HKD2_k127_5916730_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002697 509.0
HKD2_k127_5916730_1 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate K01681 - 4.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000728 407.0
HKD2_k127_5916730_2 Protein involved in meta-pathway of phenol degradation - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 342.0
HKD2_k127_5916730_3 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form K12410 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003455 289.0
HKD2_k127_596418_0 Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell K00982 - 2.7.7.42,2.7.7.89 2.927e-286 917.0
HKD2_k127_596418_1 Protein of unknown function - - - 4.418e-239 790.0
HKD2_k127_596418_10 TRAP-type C4-dicarboxylate transport system periplasmic component - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006213 447.0
HKD2_k127_596418_11 Fumarylacetoacetate (FAA) hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002656 436.0
HKD2_k127_596418_12 Fumarylacetoacetate (FAA) hydrolase family K16165 - 3.7.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007682 410.0
HKD2_k127_596418_13 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 406.0
HKD2_k127_596418_14 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K01501,K11206 - 3.5.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005154 363.0
HKD2_k127_596418_15 Belongs to the LDH2 MDH2 oxidoreductase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007395 363.0
HKD2_k127_596418_16 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000661 329.0
HKD2_k127_596418_17 Cytidylyltransferase family K00981 - 2.7.7.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001462 314.0
HKD2_k127_596418_18 Enoyl-(Acyl carrier protein) reductase K00019,K18335 - 1.1.1.30 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000004121 290.0
HKD2_k127_596418_19 KR domain K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001869 289.0
HKD2_k127_596418_2 PFAM D-galactarate dehydratase Altronate hydrolase domain protein K01685,K01708,K16846 - 4.2.1.42,4.2.1.7,4.4.1.24 6.711e-228 740.0
HKD2_k127_596418_20 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003277 280.0
HKD2_k127_596418_21 PFAM Polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001234 263.0
HKD2_k127_596418_22 Regulatory protein GntR HTH - - - 0.000000000000000000000000000000000000000000000000000000000000001048 226.0
HKD2_k127_596418_23 Protein of unknown function (DUF1345) - - - 0.0000000000000000000000000000000000000000000000000000000000009856 217.0
HKD2_k127_596418_24 PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - 0.00000000000000000000000000000000000000000000000000000001389 205.0
HKD2_k127_596418_25 branched-chain amino acid permease (azaleucine resistance) - - - 0.000000000000000000000000000000000000000000000000000002977 201.0
HKD2_k127_596418_26 prohibitin homologues - - - 0.000000000000000000000000000000000000000000000000002647 186.0
HKD2_k127_596418_27 Branched-chain amino acid transport protein (AzlD) - - - 0.0000000000000000001037 97.0
HKD2_k127_596418_28 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.000447 42.0
HKD2_k127_596418_3 Responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase K03568 - - 5.749e-227 713.0
HKD2_k127_596418_4 TRAP C4-dicarboxylate transport system permease DctM subunit K11690 - - 3.384e-224 711.0
HKD2_k127_596418_5 Bacterial extracellular solute-binding protein K02027 - - 9.04e-214 671.0
HKD2_k127_596418_6 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) K01626 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001042 597.0
HKD2_k127_596418_7 Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system K10112 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003501 509.0
HKD2_k127_596418_8 Binding-protein-dependent transport system inner membrane component K02025,K10237 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006038 503.0
HKD2_k127_596418_9 PFAM binding-protein-dependent transport systems inner membrane component K02026 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001194 484.0
HKD2_k127_5992621_0 Catalyzes cross-linking of the peptidoglycan cell wall K05515 - 3.4.16.4 3.546e-255 807.0
HKD2_k127_5992621_1 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02434 - 6.3.5.6,6.3.5.7 4.777e-221 696.0
HKD2_k127_5992621_10 Involved in formation and maintenance of cell shape K03570 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003988 308.0
HKD2_k127_5992621_11 Domain of unknown function (DUF4382) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000009403 294.0
HKD2_k127_5992621_12 LemA family K03744 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001814 278.0
HKD2_k127_5992621_13 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000005594 294.0
HKD2_k127_5992621_14 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 - 2.1.1.198 0.000000000000000000000000000000000000000000000000000000000000000000000000000001311 281.0
HKD2_k127_5992621_15 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001659 268.0
HKD2_k127_5992621_16 rod shape-determining protein MreD K03571 - - 0.000000000000000000000000000000000000000000000000000000000000000000126 241.0
HKD2_k127_5992621_17 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000000000000000000000000000000000000000000006506 231.0
HKD2_k127_5992621_18 PFAM transport-associated - - - 0.000000000000000000000000000000000000000000000004428 182.0
HKD2_k127_5992621_19 - - - - 0.00000000000000000000000000000000000000006661 162.0
HKD2_k127_5992621_2 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 8.137e-207 654.0
HKD2_k127_5992621_20 LppC putative lipoprotein K07121 - - 0.000000000000000000000000000000000000002052 163.0
HKD2_k127_5992621_21 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) K02435 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000003848 117.0
HKD2_k127_5992621_22 Belongs to the UPF0102 family K07460 - - 0.00000000000000000000000001301 119.0
HKD2_k127_5992621_23 - - - - 0.0000000000000000001034 100.0
HKD2_k127_5992621_24 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.000000000005379 65.0
HKD2_k127_5992621_3 Cell shape determining protein, MreB Mrl family K03569 - - 5.139e-201 631.0
HKD2_k127_5992621_4 Major facilitator superfamily K08218 - - 2.885e-197 628.0
HKD2_k127_5992621_5 Prolyl oligopeptidase, N-terminal beta-propeller domain K01322 - 3.4.21.26 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006313 567.0
HKD2_k127_5992621_6 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008276 496.0
HKD2_k127_5992621_7 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003361 474.0
HKD2_k127_5992621_8 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006818 378.0
HKD2_k127_5992621_9 TRAP transporter solute receptor TAXI family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005187 336.0
HKD2_k127_6109374_0 Spermidine synthase K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000002051 238.0
HKD2_k127_6109374_1 Protein of unknown function (DUF1631) - - - 0.000000000000000000000000000000000000000000000000000000003002 224.0
HKD2_k127_6109374_2 Type II secretion system (T2SS), protein E, N-terminal domain K02454 - - 0.000000000000000000000000000000000000000000000000000015 198.0
HKD2_k127_6109374_3 Protein of unknown function (DUF1631) - - - 0.000000000000000000000000000000000000000000000000004571 206.0
HKD2_k127_61995_0 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family K14393 - - 6.428e-275 857.0
HKD2_k127_61995_1 Tripartite ATP-independent periplasmic transporter, DctM component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001138 372.0
HKD2_k127_61995_10 His Kinase A (phosphoacceptor) domain - - - 0.00003723 46.0
HKD2_k127_61995_2 N-formylglutamate amidohydrolase K01458 - 3.5.1.68 0.000000000000000000000000000000000000000000000000000000000000000000000000000000431 273.0
HKD2_k127_61995_3 protein domain associated with - - - 0.000000000000000000000000000000000000000013 158.0
HKD2_k127_61995_4 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000573 134.0
HKD2_k127_61995_5 Protein of unknown function, DUF485 - - - 0.00000000000000000000000000000002661 135.0
HKD2_k127_61995_6 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family - - - 0.000000000000000000005707 103.0
HKD2_k127_61995_7 - - - - 0.00000000000000008782 87.0
HKD2_k127_61995_9 - - - - 0.0000001653 61.0
HKD2_k127_6213407_0 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate K01712 - 4.2.1.49 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002219 515.0
HKD2_k127_6213407_1 Histidine ammonia-lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005031 456.0
HKD2_k127_6302611_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.0 1384.0
HKD2_k127_6302611_1 homoserine dehydrogenase K00003 - 1.1.1.3 1.612e-200 633.0
HKD2_k127_6302611_10 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K03636 - - 0.00000000000000000000008093 104.0
HKD2_k127_6302611_11 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.0000007529 52.0
HKD2_k127_6302611_2 Threonine synthase N terminus K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001434 616.0
HKD2_k127_6302611_3 Probable molybdopterin binding domain K03750 - 2.10.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008069 495.0
HKD2_k127_6302611_4 protein conserved in bacteria K09800 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001484 502.0
HKD2_k127_6302611_5 surface antigen (D15) K07278 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002701 458.0
HKD2_k127_6302611_6 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002309 298.0
HKD2_k127_6302611_7 PFAM molybdopterin biosynthesis MoaE K03635 - 2.8.1.12 0.000000000000000000000000000000000000000000000000000000000000000003675 228.0
HKD2_k127_6302611_8 molybdopterin-guanine dinucleotide biosynthesis protein K03753 - - 0.000000000000000000000000000000000000000000000000000001532 199.0
HKD2_k127_6302611_9 Important for reducing fluoride concentration in the cell, thus reducing its toxicity K06199 - - 0.000000000000000000000000000000000000000002179 158.0
HKD2_k127_6386475_0 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S K03149 - 2.8.1.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 425.0
HKD2_k127_6386475_1 Polyphosphate kinase 2 (PPK2) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008588 414.0
HKD2_k127_6386475_2 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00436 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.12.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000001042 249.0
HKD2_k127_6386475_3 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.000000000000000000000000000000000000000001276 167.0
HKD2_k127_6386475_4 redox protein regulator of disulfide bond formation - - - 0.00000000000000000000000000000000007713 141.0
HKD2_k127_6386475_5 Hydrogenase maturation protease - - - 0.0000000000000000000001998 104.0
HKD2_k127_6386475_6 ThiS family K03154 - - 0.00000000000000000002786 91.0
HKD2_k127_6389852_0 Histidine kinase K07649 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002311 542.0
HKD2_k127_6389852_1 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage K03553 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000131 461.0
HKD2_k127_6389852_2 Transcriptional regulatory protein, C terminal K02483,K07666,K07774 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003165 353.0
HKD2_k127_6389852_3 RND efflux system, outer membrane lipoprotein K18139,K18903 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004081 353.0
HKD2_k127_6389852_4 - - - - 0.0000398 49.0
HKD2_k127_6401152_0 Tripartite tricarboxylate transporter TctA family - - - 1.529e-245 766.0
HKD2_k127_6401152_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072 - - 8.57e-244 768.0
HKD2_k127_6401152_10 Tripartite tricarboxylate transporter family receptor - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001752 413.0
HKD2_k127_6401152_11 Tripartite tricarboxylate transporter family receptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009381 391.0
HKD2_k127_6401152_12 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001193 347.0
HKD2_k127_6401152_13 Glutathione S-transferase K00799 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001594 302.0
HKD2_k127_6401152_14 Glycerophosphoryl diester phosphodiesterase K01126 - 3.1.4.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006824 296.0
HKD2_k127_6401152_15 Deoxynucleoside kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002963 275.0
HKD2_k127_6401152_16 SnoaL-like polyketide cyclase - - - 0.00000000000000000000000000000000000000000000000000000000000000000253 228.0
HKD2_k127_6401152_17 RDD family - - - 0.00000000000000000000000000000000000000000000000000000003715 200.0
HKD2_k127_6401152_18 Protein conserved in bacteria K09922 - - 0.000000000000000000000000000000000000000000000000000009644 190.0
HKD2_k127_6401152_19 Acetyltransferase (GNAT) domain K03790 - 2.3.1.128 0.00000000000000000000000000000000000000000000003089 177.0
HKD2_k127_6401152_2 gamma-glutamyltransferase K00681 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 7.035e-220 694.0
HKD2_k127_6401152_20 enzyme involved in biosynthesis of extracellular polysaccharides - - - 0.00000000000000000000000000000000000000757 147.0
HKD2_k127_6401152_21 Tripartite tricarboxylate transporter TctB family - - - 0.0000000000000000000000000000000007946 136.0
HKD2_k127_6401152_22 TIGRFAM preprotein translocase, YajC subunit K03210 - - 0.000000000000000000000000000000003827 132.0
HKD2_k127_6401152_23 Endoribonuclease L-PSP - - - 0.00000000000000000000000000000002582 129.0
HKD2_k127_6401152_24 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000000001709 128.0
HKD2_k127_6401152_25 Belongs to the acylphosphatase family K01512 - 3.6.1.7 0.00000000000000000008102 101.0
HKD2_k127_6401152_26 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) K00950 - 2.7.6.3 0.00000000003078 64.0
HKD2_k127_6401152_3 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily K01756 - 4.3.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009728 602.0
HKD2_k127_6401152_4 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001339 597.0
HKD2_k127_6401152_5 L-carnitine dehydratase bile acid-inducible protein F K07749 - 2.8.3.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000784 575.0
HKD2_k127_6401152_6 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 550.0
HKD2_k127_6401152_7 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate K01918 - 6.3.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005506 437.0
HKD2_k127_6401152_8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001763 437.0
HKD2_k127_6401152_9 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) K07568 GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006042 427.0
HKD2_k127_6401945_0 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.0000000000000000000000000008979 125.0
HKD2_k127_6401945_1 Bifunctional aspartokinase homoserine dehydrogenase K12524 - 1.1.1.3,2.7.2.4 0.000000000001485 72.0
HKD2_k127_6401945_2 Pfam:Pyridox_oxidase K07006 - - 0.000215 44.0
HKD2_k127_6406516_0 AcrB/AcrD/AcrF family - - - 0.0 1615.0
HKD2_k127_6406516_1 PFAM FAD linked oxidase domain protein K00102,K03777 - 1.1.2.4,1.1.5.12 5.359e-214 674.0
HKD2_k127_6406516_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008814 401.0
HKD2_k127_6406516_3 PFAM Transcriptional regulator, TetR-like, DNA-binding, bacterial archaeal - - - 0.000000000000000000000000000000000000000002315 165.0
HKD2_k127_6406516_4 Adenosyltransferase K00798 GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 0.000000000000000000000000000000000000002458 149.0
HKD2_k127_6413473_0 MBOAT, membrane-bound O-acyltransferase family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 564.0
HKD2_k127_6413473_1 Metallo-beta-lactamase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000581 545.0
HKD2_k127_6413473_2 VIT family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001127 301.0
HKD2_k127_6413473_3 Belongs to the peptidase M16 family K07263 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001239 250.0
HKD2_k127_6413473_4 - - - - 0.0000000000000000000000000000000000000000000000002043 193.0
HKD2_k127_6413473_5 Thioesterase-like superfamily K07107 - - 0.0000000000000000000000000000000000000000000001414 174.0
HKD2_k127_6413473_6 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000001791 163.0
HKD2_k127_6422286_0 Belongs to the peptidase M16 family K07263 - - 1.868e-310 972.0
HKD2_k127_6422286_1 Alpha beta hydrolase - - - 0.000000000000000000000000000000000005823 139.0
HKD2_k127_6438914_0 Urease alpha-subunit, N-terminal domain K01428 - 3.5.1.5 0.0 1032.0
HKD2_k127_6438914_1 Alkyl sulfatase dimerisation - - - 4.84e-322 1002.0
HKD2_k127_6438914_10 UreF K03188 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002924 314.0
HKD2_k127_6438914_11 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly K03187 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006849 313.0
HKD2_k127_6438914_12 permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000791 319.0
HKD2_k127_6438914_13 Phospholipase K01058 GO:0003674,GO:0003824,GO:0004620,GO:0004623,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005623,GO:0008970,GO:0009279,GO:0016020,GO:0016021,GO:0016298,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044462,GO:0044464,GO:0045203,GO:0046872,GO:0046983,GO:0052689,GO:0071944 3.1.1.32,3.1.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001413 284.0
HKD2_k127_6438914_14 Urease beta subunit - - - 0.00000000000000000000000000000000000000000000000000000000002105 209.0
HKD2_k127_6438914_15 Urease, gamma subunit K01430 - 3.5.1.5 0.000000000000000000000000000000000000000000000009907 173.0
HKD2_k127_6438914_16 LysR substrate binding domain - - - 0.000000000000001376 79.0
HKD2_k127_6438914_2 Transketolase, C-terminal domain K00167 - 1.2.4.4 4.425e-195 615.0
HKD2_k127_6438914_3 Dehydrogenase E1 component K00166 - 1.2.4.4 1.861e-194 614.0
HKD2_k127_6438914_4 Serine aminopeptidase, S33 K03928 - 3.1.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000832 623.0
HKD2_k127_6438914_5 Protein of unknown function (DUF1576) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001829 588.0
HKD2_k127_6438914_6 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) component and related enzymes K09699 - 2.3.1.168 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004361 539.0
HKD2_k127_6438914_7 UreD urease accessory protein K03190 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003243 460.0
HKD2_k127_6438914_8 Urea transporter K08717 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 380.0
HKD2_k127_6438914_9 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG K03189 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002501 368.0
HKD2_k127_6455516_0 Parallel beta-helix repeats - - - 0.0 2932.0
HKD2_k127_6455516_1 Multicopper oxidase, type 3 - - - 5.778e-241 754.0
HKD2_k127_6455516_10 Cytochrome c554 and c-prime - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006729 435.0
HKD2_k127_6455516_11 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003933 400.0
HKD2_k127_6455516_12 Belongs to the V-ATPase 116 kDa subunit family K02123 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004962 410.0
HKD2_k127_6455516_13 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000155 359.0
HKD2_k127_6455516_14 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008051 324.0
HKD2_k127_6455516_15 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005271 298.0
HKD2_k127_6455516_16 branched-chain amino acid K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 299.0
HKD2_k127_6455516_17 Type II secretion system (T2SS), protein F K02455 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003473 286.0
HKD2_k127_6455516_18 helix_turn_helix, Lux Regulon K14979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000009137 264.0
HKD2_k127_6455516_19 Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001653 248.0
HKD2_k127_6455516_2 Multicopper oxidase - - - 2.791e-216 685.0
HKD2_k127_6455516_20 Bacterial regulatory proteins, luxR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000024 245.0
HKD2_k127_6455516_21 SCO1/SenC K07152 - - 0.00000000000000000000000000000000000000000000000000000000000000000001052 242.0
HKD2_k127_6455516_22 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000001323 221.0
HKD2_k127_6455516_23 His Kinase A (phospho-acceptor) domain K02484,K07645 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000001609 231.0
HKD2_k127_6455516_24 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000000000000000000000000000000000000000000000000000002887 233.0
HKD2_k127_6455516_25 general secretion pathway protein G K02456 - - 0.00000000000000000000000000000000000000000000000000000001092 202.0
HKD2_k127_6455516_26 Pfam:N_methyl_2 K02456 - - 0.0000000000000000000000000000000000000000000003581 171.0
HKD2_k127_6455516_27 - - - - 0.0000000000000000000000000000000000000000001118 166.0
HKD2_k127_6455516_28 regulator - - - 0.00000000000000000000000000000000000000001582 160.0
HKD2_k127_6455516_29 Transglycosylase SLT domain K08309 - - 0.00000000000000000000000000000000000000005836 161.0
HKD2_k127_6455516_3 Cytochrome c - - - 6.964e-203 647.0
HKD2_k127_6455516_30 Belongs to the peptidase S8 family - - - 0.000000000000000000000000000000000000009107 166.0
HKD2_k127_6455516_31 Prokaryotic N-terminal methylation motif K02456 - - 0.0000000000000000000000000000000000003296 145.0
HKD2_k127_6455516_32 Type II secretory pathway, pseudopilin - - - 0.0000000000000000000000000000000001266 144.0
HKD2_k127_6455516_33 ATP synthase subunit D K02120 - - 0.0000000000000000000000000000000008382 145.0
HKD2_k127_6455516_34 Histidine kinase - - - 0.000000000000000000000000000000005817 141.0
HKD2_k127_6455516_35 Cyclase dehydrase - - - 0.000000000000000000000000000001562 126.0
HKD2_k127_6455516_36 - - - - 0.000000000000000000000004834 109.0
HKD2_k127_6455516_37 Belongs to the V-ATPase proteolipid subunit family K02124 - - 0.0000000000000000000002716 100.0
HKD2_k127_6455516_38 - - - - 0.0000000000000000000005874 104.0
HKD2_k127_6455516_39 - - - - 0.000000000000000000008678 102.0
HKD2_k127_6455516_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit K02118 - - 4.126e-199 632.0
HKD2_k127_6455516_40 - - - - 0.00000000000000001983 91.0
HKD2_k127_6455516_41 Cytochrome c K08738 - - 0.00000000000003954 77.0
HKD2_k127_6455516_42 carbon utilization - - - 0.000000000000382 77.0
HKD2_k127_6455516_43 PFAM Cytochrome c, class I K08738 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - 0.000000000141 66.0
HKD2_k127_6455516_44 CAAX protease self-immunity K07052 - - 0.0000000008015 68.0
HKD2_k127_6455516_45 ATP synthase (F/14-kDa) subunit - - - 0.000001625 53.0
HKD2_k127_6455516_47 - - - - 0.0009509 49.0
HKD2_k127_6455516_5 Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate K08289 - 2.1.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003707 581.0
HKD2_k127_6455516_6 type II secretion system protein E K02454,K02652 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002431 583.0
HKD2_k127_6455516_7 type II and III secretion system protein K02453 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009146 578.0
HKD2_k127_6455516_8 ATPsynthase alpha/beta subunit N-term extension K02117 - 3.6.3.14,3.6.3.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004899 547.0
HKD2_k127_6455516_9 ABC-type branched-chain amino acid transport systems periplasmic component K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004537 511.0
HKD2_k127_6483644_0 o-acetylhomoserine K01740 - 2.5.1.49 4.938e-207 655.0
HKD2_k127_6483644_1 Belongs to the peptidase S33 family K01259 - 3.4.11.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008155 437.0
HKD2_k127_6483644_2 Belongs to the hyi family K01816,K22131 - 5.3.1.22,5.3.1.35 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001405 284.0
HKD2_k127_6483644_3 CBS domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000007742 234.0
HKD2_k127_6483644_4 cyclic nucleotide binding K10914 - - 0.00000000000000000004038 96.0
HKD2_k127_6504827_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006924 542.0
HKD2_k127_6504827_1 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002134 421.0
HKD2_k127_6504827_2 abc transporter K02003,K05685 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000974 342.0
HKD2_k127_6504827_3 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000000000000000000000005096 159.0
HKD2_k127_6504827_4 - - - - 0.0000000000000000000000000008406 123.0
HKD2_k127_6504827_5 Protein of unknown function (DUF1439) - - - 0.000002418 57.0
HKD2_k127_6504827_6 Histidine kinase - - - 0.0005393 53.0
HKD2_k127_6504827_7 Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - 0.0005393 53.0
HKD2_k127_6545068_0 dna topoisomerase III K03169 - 5.99.1.2 0.0 1176.0
HKD2_k127_6545068_1 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 7.352e-302 940.0
HKD2_k127_6545068_10 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004913 338.0
HKD2_k127_6545068_11 LysM domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002001 341.0
HKD2_k127_6545068_12 PFAM alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002878 334.0
HKD2_k127_6545068_13 response regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004525 277.0
HKD2_k127_6545068_14 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009545 285.0
HKD2_k127_6545068_15 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000000000000000000000000001504 252.0
HKD2_k127_6545068_16 signal peptide protein - - - 0.00000000000000000000000000000000000000000000006512 178.0
HKD2_k127_6545068_17 Belongs to the Smg family K03747 - - 0.000000000000000000000000000000000000000002148 160.0
HKD2_k127_6545068_2 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - 6.254e-218 701.0
HKD2_k127_6545068_3 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 6.035e-210 660.0
HKD2_k127_6545068_4 PFAM TrkA-N domain protein K03499 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002596 563.0
HKD2_k127_6545068_5 Protein of unknown function (DUF1298) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000148 479.0
HKD2_k127_6545068_6 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001175 398.0
HKD2_k127_6545068_7 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008643 382.0
HKD2_k127_6545068_8 DNA recombination-mediator protein A K04096 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 382.0
HKD2_k127_6545068_9 Tripartite ATP-independent periplasmic - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006321 353.0
HKD2_k127_6546116_0 Membrane-bound lytic murein transglycosylase K08304 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001661 401.0
HKD2_k127_6546116_1 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process K03981 - 5.3.4.1 0.000000000000000000000000000000000000000000000000000000124 204.0
HKD2_k127_6546116_2 ApaG domain K06195 - - 0.000000000000000000000000000000000000000000000000001484 185.0
HKD2_k127_6546116_3 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.000000000000000000000000000000000000002137 149.0
HKD2_k127_6546116_4 Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family - - - 0.00000000000000000000001383 102.0
HKD2_k127_654748_0 glutamate synthase K00265,K00284 - 1.4.1.13,1.4.1.14,1.4.7.1 0.0 1763.0
HKD2_k127_654748_1 Belongs to the dGTPase family. Type 2 subfamily K01129 - 3.1.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 537.0
HKD2_k127_654748_2 ATP ADP translocase K03301 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 344.0
HKD2_k127_654748_3 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003107 288.0
HKD2_k127_654748_4 Transposase IS200 like K07491 - - 0.00000000000000000000000000000000000000000000000000002483 196.0
HKD2_k127_6608512_0 Histidine kinase K02487,K06596 - - 0.0 1232.0
HKD2_k127_6608512_1 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). K02660 - - 2.33e-215 691.0
HKD2_k127_6608512_2 DNA photolyase K01669 - 4.1.99.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001051 563.0
HKD2_k127_6608512_3 intramolecular transferase activity, transferring amino groups K01845 - 5.4.3.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008467 302.0
HKD2_k127_6608512_4 cheY-homologous receiver domain K02657 - - 0.000000000000000000000000000000000000000000000000000000000006949 214.0
HKD2_k127_6608512_5 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.00000000000000000000000000000000000000000000000000000002733 207.0
HKD2_k127_6608512_6 cheY-homologous receiver domain K02658 - - 0.000000000000000000000000000000000000000000000000000005445 192.0
HKD2_k127_6608512_7 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) - - - 0.000000000000000000000000000000000000000004399 167.0
HKD2_k127_6608512_8 PFAM Rubredoxin-type Fe(Cys)4 protein - - - 0.0000000000000000000000000000005738 123.0
HKD2_k127_6608512_9 Chemotaxis signal transduction protein K02659 - - 0.000000000000000000000000005414 117.0
HKD2_k127_6616184_0 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00525 GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 0.0 1544.0
HKD2_k127_6616184_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 - - 0.0 1296.0
HKD2_k127_6616184_10 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03106 - 3.6.5.4 4.504e-201 647.0
HKD2_k127_6616184_11 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan K01000 - 2.7.8.13 4.987e-198 621.0
HKD2_k127_6616184_12 Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate K02558 - 6.3.2.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006366 594.0
HKD2_k127_6616184_13 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001516 575.0
HKD2_k127_6616184_14 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008558 569.0
HKD2_k127_6616184_15 type II secretion system protein K02653 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 560.0
HKD2_k127_6616184_16 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate K00931 - 2.7.2.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003847 552.0
HKD2_k127_6616184_17 Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein K01929 - 6.3.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001324 563.0
HKD2_k127_6616184_18 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 547.0
HKD2_k127_6616184_19 Sigma-54 interaction domain K02667 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003461 546.0
HKD2_k127_6616184_2 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 2.339e-273 851.0
HKD2_k127_6616184_20 Peptidoglycan polymerase that is essential for cell division K03588 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 526.0
HKD2_k127_6616184_21 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 486.0
HKD2_k127_6616184_22 COG0524 Sugar kinases, ribokinase family K00856 - 2.7.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001438 428.0
HKD2_k127_6616184_23 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001912 438.0
HKD2_k127_6616184_24 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) K02563 - 2.4.1.227 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000103 418.0
HKD2_k127_6616184_25 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535 - 3.5.1.108 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000848 403.0
HKD2_k127_6616184_26 Cell wall formation K01921 - 6.3.2.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 404.0
HKD2_k127_6616184_27 Belongs to the FPP GGPP synthase family K02523 - 2.5.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002553 401.0
HKD2_k127_6616184_28 SMART AAA ATPase K06923 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 370.0
HKD2_k127_6616184_29 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003263 360.0
HKD2_k127_6616184_3 Biotin carboxylase K01961 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 2.238e-253 785.0
HKD2_k127_6616184_30 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02654 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000673 356.0
HKD2_k127_6616184_31 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 - 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007407 355.0
HKD2_k127_6616184_32 His Kinase A (phosphoacceptor) domain K02668,K10125 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009912 338.0
HKD2_k127_6616184_33 Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity K18778 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007532 319.0
HKD2_k127_6616184_34 Methylates ribosomal protein L11 K02687 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001723 332.0
HKD2_k127_6616184_35 Peptidase family M23 K08259 - 3.4.24.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005477 319.0
HKD2_k127_6616184_36 Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage K08311 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001103 299.0
HKD2_k127_6616184_37 Belongs to the Nudix hydrolase family K03574 - 3.6.1.55 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000009822 302.0
HKD2_k127_6616184_38 Predicted integral membrane protein (DUF2189) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001829 278.0
HKD2_k127_6616184_39 Cytochrome c assembly protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004747 246.0
HKD2_k127_6616184_4 Type II secretion system (T2SS), protein E, N-terminal domain K02454,K02504,K02652 - - 1.852e-246 773.0
HKD2_k127_6616184_40 Transglycosylase SLT domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000006401 243.0
HKD2_k127_6616184_41 UPF0056 inner membrane protein K05595 - - 0.00000000000000000000000000000000000000000000000000000000000000007366 230.0
HKD2_k127_6616184_42 Ami_2 K03806 GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000004004 224.0
HKD2_k127_6616184_43 Uncharacterised protein family (UPF0227) K07000 - - 0.000000000000000000000000000000000000000000000000000000000002156 227.0
HKD2_k127_6616184_44 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000000000000000000000000000000000009308 207.0
HKD2_k127_6616184_45 Catalyzes a trans-dehydration via an enolate intermediate K03786 - 4.2.1.10 0.0000000000000000000000000000000000000000000000000000000008865 204.0
HKD2_k127_6616184_46 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.00000000000000000000000000000000000000000000000000002575 191.0
HKD2_k127_6616184_47 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly K03589 - - 0.000000000000000000000000000000000000000000000000004265 192.0
HKD2_k127_6616184_48 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 - 2.7.1.24 0.00000000000000000000000000000000000000000000000002818 189.0
HKD2_k127_6616184_49 Aminoacyl-tRNA editing domain - - - 0.000000000000000000000000000000000000000000007284 167.0
HKD2_k127_6616184_5 Belongs to the MurCDEF family K01924 - 6.3.2.8 2.907e-222 699.0
HKD2_k127_6616184_50 Protein of unknown function (DUF3426) - - - 0.00000000000000000000000000000000000001176 161.0
HKD2_k127_6616184_51 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.00000000000000000000000000000000000001881 146.0
HKD2_k127_6616184_52 mRNA catabolic process - - - 0.0000000000000000000000000000000000007418 149.0
HKD2_k127_6616184_53 Redoxin domain protein - - - 0.00000000000000000000000000000000001682 145.0
HKD2_k127_6616184_54 Belongs to the bacterial ribosomal protein bL27 family K02899 GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - 0.00000000000000000000000000000000008694 134.0
HKD2_k127_6616184_55 YGGT family K02221 - - 0.000000000000000000000000000000001738 137.0
HKD2_k127_6616184_56 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase K09862 - - 0.0000000000000001803 81.0
HKD2_k127_6616184_57 Histone H1-like nucleoprotein HC2 K11275 - - 0.000000000000003307 83.0
HKD2_k127_6616184_58 - K06950 - - 0.00000000004843 70.0
HKD2_k127_6616184_59 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic K03586 - - 0.0000004544 55.0
HKD2_k127_6616184_6 RNB K01147 - 3.1.13.1 4.387e-222 706.0
HKD2_k127_6616184_7 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides K00526 - 1.17.4.1 1.863e-214 670.0
HKD2_k127_6616184_8 Catalyzes cross-linking of the peptidoglycan cell wall at the division septum K03587 - 3.4.16.4 2.456e-205 660.0
HKD2_k127_6616184_9 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 9.343e-205 649.0
HKD2_k127_6635525_0 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004886 500.0
HKD2_k127_6635525_1 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group K02227 - 6.3.1.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000003093 278.0
HKD2_k127_6635525_2 Isochorismatase hydrolase - - - 0.00000000000000000000000000000000000000000000000000002799 193.0
HKD2_k127_6635525_3 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000003984 121.0
HKD2_k127_6635525_4 part of a sulfur-relay system K11179 - - 0.000000000000000000001286 95.0
HKD2_k127_6635525_5 - - - - 0.000000000000000000001468 96.0
HKD2_k127_6635525_6 part of a sulfur-relay system K11179 - - 0.0000000001858 67.0
HKD2_k127_6679839_0 orn lys arg decarboxylase K01584 - 4.1.1.19 0.0 1249.0
HKD2_k127_6679839_1 C-terminal region of aryl-sulfatase - - - 0.0 1019.0
HKD2_k127_6679839_10 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002676 490.0
HKD2_k127_6679839_11 The glycine cleavage system catalyzes the degradation of glycine K00605 GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 2.1.2.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001363 490.0
HKD2_k127_6679839_12 Beta-eliminating lyase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004992 484.0
HKD2_k127_6679839_13 Binding-protein-dependent transport system inner membrane component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005306 473.0
HKD2_k127_6679839_14 COG1840 ABC-type Fe3 transport system, periplasmic component K02055 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 471.0
HKD2_k127_6679839_15 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP K00647,K09458 - 2.3.1.179,2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 471.0
HKD2_k127_6679839_16 TIGRFAM oligopeptide dipeptide ABC transporter, ATPase subunit K02031 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005673 451.0
HKD2_k127_6679839_17 AAA domain (dynein-related subfamily) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004476 430.0
HKD2_k127_6679839_18 VWA domain containing CoxE-like protein K07161 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006329 447.0
HKD2_k127_6679839_19 Adenylyl- / guanylyl cyclase, catalytic domain K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007957 405.0
HKD2_k127_6679839_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.808e-273 853.0
HKD2_k127_6679839_20 Belongs to the ABC transporter superfamily K02052 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 418.0
HKD2_k127_6679839_21 NmrA-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001247 392.0
HKD2_k127_6679839_22 Binding-protein-dependent transport system inner membrane component K02053 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003197 387.0
HKD2_k127_6679839_23 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000306 365.0
HKD2_k127_6679839_24 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis K01494 - 3.5.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003369 359.0
HKD2_k127_6679839_25 Binding-protein-dependent transport system inner membrane component K02053 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004906 366.0
HKD2_k127_6679839_26 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes K03651 - 3.1.4.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001151 351.0
HKD2_k127_6679839_27 Beta-ketoacyl synthase, C-terminal domain K00647 - 2.3.1.41 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004198 352.0
HKD2_k127_6679839_28 Putative serine dehydratase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001649 348.0
HKD2_k127_6679839_29 KR domain K10780 - 1.3.1.104 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000003659 301.0
HKD2_k127_6679839_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 1.057e-234 742.0
HKD2_k127_6679839_30 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000001338 261.0
HKD2_k127_6679839_31 lipid A biosynthesis K02517 - 2.3.1.241 0.00000000000000000000000000000000000000000000000000000000000000002198 240.0
HKD2_k127_6679839_32 - - - - 0.000000000000000000000000000000000000000000000000000000000000003237 224.0
HKD2_k127_6679839_33 with different specificities (related to short-chain alcohol K00059 - 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000006889 232.0
HKD2_k127_6679839_34 LysR substrate binding domain - - - 0.000000000000000000000000000000000000000000000000000000001284 213.0
HKD2_k127_6679839_35 ubiE/COQ5 methyltransferase family - - - 0.00000000000000000000000000000000000000000000000000003867 199.0
HKD2_k127_6679839_36 carbon monoxide dehydrogenase K09386 - - 0.00000000000000000000000000000000000000000000001193 180.0
HKD2_k127_6679839_37 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.0000000000000000000000000000000000000000000009704 169.0
HKD2_k127_6679839_38 Carboxymuconolactone decarboxylase family - - - 0.000000000000000000000000000000000000000000004938 177.0
HKD2_k127_6679839_39 curli production assembly transport component CsgG K06214,K13586 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0019867,GO:0022610,GO:0030288,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0033036,GO:0042597,GO:0042710,GO:0042802,GO:0042886,GO:0044010,GO:0044425,GO:0044462,GO:0044464,GO:0044764,GO:0045184,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098552 - 0.000000000000000000000000000000000000002993 165.0
HKD2_k127_6679839_4 D-amino acid K00285 - 1.4.5.1 7.788e-212 663.0
HKD2_k127_6679839_40 Phosphopantetheine attachment site - - - 0.0000000000000000000000000000000002579 138.0
HKD2_k127_6679839_41 PFAM GYD family protein - - - 0.0000000000000000000000000000000007154 132.0
HKD2_k127_6679839_42 FabA-like domain - - - 0.000000000000000000000902 106.0
HKD2_k127_6679839_43 spectrin binding K15502,K19947 - 1.14.13.225 0.000000000000000002409 100.0
HKD2_k127_6679839_44 Histidine kinase K20976 - - 0.00000000000000002264 97.0
HKD2_k127_6679839_45 - - - - 0.0000000000000851 81.0
HKD2_k127_6679839_46 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00652 - 2.3.1.47 0.00000004182 64.0
HKD2_k127_6679839_47 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281 - 1.4.4.2 0.000001553 52.0
HKD2_k127_6679839_48 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein K00997 - 2.7.8.7 0.00006562 55.0
HKD2_k127_6679839_5 Transmembrane secretion effector - - - 4.04e-200 640.0
HKD2_k127_6679839_6 PhoQ Sensor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006593 661.0
HKD2_k127_6679839_7 Binding-protein-dependent transport system inner membrane component K02033 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003654 512.0
HKD2_k127_6679839_8 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006532 525.0
HKD2_k127_6679839_9 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005651 522.0
HKD2_k127_6680116_0 PFAM Sulfatase - - - 0.0 1210.0
HKD2_k127_6680116_1 MmgE PrpD family protein - - - 8.284e-197 635.0
HKD2_k127_6680116_2 L-carnitine dehydratase bile acid-inducible protein F K18289 - 2.8.3.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001043 371.0
HKD2_k127_6680116_3 OPT oligopeptide transporter protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000001825 237.0
HKD2_k127_6680116_4 Orotidine 5'-phosphate decarboxylase K13831 - 4.1.2.43,5.3.1.27 0.0000000000000000000000000000000000000000001183 170.0
HKD2_k127_6680116_5 Small Multidrug Resistance protein K03297 - - 0.0000000000000000000000000000000000000000006097 159.0
HKD2_k127_6680116_6 LysR substrate binding domain - - - 0.00000000000000000000000000000000102 142.0
HKD2_k127_6711061_0 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002758 522.0
HKD2_k127_6711061_1 membrane - - - 0.0000000000000000000000000000000000001492 145.0
HKD2_k127_6793550_0 acyl-CoA dehydrogenase - - - 8.186e-261 812.0
HKD2_k127_6793550_1 Acyl-CoA synthetase (NDP forming) K09181 - - 1.512e-249 799.0
HKD2_k127_6793550_10 TraB family K09973 - - 0.00000000000000000000000000000000000000000001247 178.0
HKD2_k127_6793550_11 Membrane K15977 - - 0.00000000000000000000000000000000000000000003093 165.0
HKD2_k127_6793550_12 assembly chaperone K07346 - - 0.000000000000000000000001146 113.0
HKD2_k127_6793550_13 Prokaryotic dksA/traR C4-type zinc finger - - - 0.000000000000003996 81.0
HKD2_k127_6793550_14 Belongs to the ompA family K03286 - - 0.00000002829 63.0
HKD2_k127_6793550_15 Secreted protein - - - 0.00000006802 61.0
HKD2_k127_6793550_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001345 439.0
HKD2_k127_6793550_3 Catalytic LigB subunit of aromatic ring-opening dioxygenase K15777 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 301.0
HKD2_k127_6793550_4 Transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000003605 291.0
HKD2_k127_6793550_5 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000006491 262.0
HKD2_k127_6793550_6 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000001619 240.0
HKD2_k127_6793550_7 Class II Aldolase and Adducin N-terminal domain K01628 - 4.1.2.17 0.00000000000000000000000000000000000000000000000000000000000000000007932 242.0
HKD2_k127_6793550_8 Calcineurin-like phosphoesterase K06953 - - 0.0000000000000000000000000000000000000000000000000000000000000000001027 237.0
HKD2_k127_6793550_9 outer membrane usher protein K07347 - - 0.000000000000000000000000000000000000000000000000000000000000005367 238.0
HKD2_k127_6823797_0 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA K03498 - - 2.514e-201 638.0
HKD2_k127_6823797_1 Belongs to the GMC oxidoreductase family K00108 - 1.1.99.1 8.069e-199 633.0
HKD2_k127_6823797_2 B12 binding domain K00548 - 2.1.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006655 580.0
HKD2_k127_6823797_3 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.00000000000000000000000000000000000000000000000000000000000000000000008574 254.0
HKD2_k127_6823797_4 Protein of unknown function (DUF3567) - - - 0.00000000000000000000008889 100.0
HKD2_k127_6823797_5 cobalamin synthesis protein, P47K - GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0008270,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.000004342 55.0
HKD2_k127_6837120_0 Tetratricopeptide repeat K02200 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002291 302.0
HKD2_k127_6837120_1 Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - 0.0000000000000000000000000000000000004438 146.0
HKD2_k127_6858239_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533 4.1.1.32 0.0 1020.0
HKD2_k127_6858239_1 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 K03495 - - 0.0 1003.0
HKD2_k127_6858239_10 Natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007687 597.0
HKD2_k127_6858239_11 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 596.0
HKD2_k127_6858239_12 ABC-type branched-chain amino acid transport system, periplasmic component K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006047 585.0
HKD2_k127_6858239_13 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 K03650 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014 561.0
HKD2_k127_6858239_14 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 - 4.1.1.37 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008272 529.0
HKD2_k127_6858239_15 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002461 489.0
HKD2_k127_6858239_16 Dehydrogenase K00043 - 1.1.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 483.0
HKD2_k127_6858239_17 Multidrug ABC transporter permease K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002804 475.0
HKD2_k127_6858239_18 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001651 463.0
HKD2_k127_6858239_19 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 436.0
HKD2_k127_6858239_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 - 2.6.1.16 4.506e-307 951.0
HKD2_k127_6858239_20 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008999 423.0
HKD2_k127_6858239_21 chromosome partitioning K03496 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004788 404.0
HKD2_k127_6858239_22 Abc transporter K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000302 404.0
HKD2_k127_6858239_23 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 396.0
HKD2_k127_6858239_24 Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) K03183 - 2.1.1.163,2.1.1.201 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 383.0
HKD2_k127_6858239_25 Amino acid amide ABC transporter ATP-binding protein 2, HAAT family K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003171 374.0
HKD2_k127_6858239_26 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008447 371.0
HKD2_k127_6858239_27 Belongs to the ParB family K03497 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 351.0
HKD2_k127_6858239_28 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003649 350.0
HKD2_k127_6858239_29 guanyl-nucleotide exchange factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003997 364.0
HKD2_k127_6858239_3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 1.661e-277 858.0
HKD2_k127_6858239_30 PFAM conserved K07795 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000509 345.0
HKD2_k127_6858239_31 abc transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000407 339.0
HKD2_k127_6858239_32 haloacid dehalogenase-like hydrolase K02203 - 2.7.1.39,3.1.3.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000494 329.0
HKD2_k127_6858239_33 Pfam:AmoA K07120 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 328.0
HKD2_k127_6858239_34 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 301.0
HKD2_k127_6858239_35 His Kinase A (phospho-acceptor) domain K02484,K07645 - 2.7.13.3 0.0000000000000000000000000000000000000000000000000000000000000000000000104 261.0
HKD2_k127_6858239_36 Lysine exporter protein (Lyse ygga) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002573 244.0
HKD2_k127_6858239_37 Transcriptional regulatory protein, C terminal K02483,K07666 - - 0.0000000000000000000000000000000000000000000000000000000000000000000004092 247.0
HKD2_k127_6858239_38 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000000000000000000000000000000000000000000000000000000002991 241.0
HKD2_k127_6858239_39 transmembrane transcriptional regulator (Anti-sigma factor) - - - 0.00000000000000000000000000000000000000000000000000000000000000003087 231.0
HKD2_k127_6858239_4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 1.568e-262 813.0
HKD2_k127_6858239_40 Cytochrome b/b6/petB - - - 0.000000000000000000000000000000000000000000000000000000000000211 220.0
HKD2_k127_6858239_41 import inner membrane translocase, subunit Tim44 - - - 0.0000000000000000000000000000000000000000000000000000001115 207.0
HKD2_k127_6858239_42 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) K02109 - - 0.000000000000000000000000000000000000000000000000000007559 194.0
HKD2_k127_6858239_43 Protein of unknown function (DUF971) - - - 0.00000000000000000000000000000000000000000000000000005481 192.0
HKD2_k127_6858239_44 Produces ATP from ADP in the presence of a proton gradient across the membrane K02114 - - 0.00000000000000000000000000000000000000000000000001131 183.0
HKD2_k127_6858239_45 FR47-like protein - - - 0.0000000000000000000000000000000000000000000000001373 186.0
HKD2_k127_6858239_46 rRNA small subunit methyltransferase G K03501 - 2.1.1.170 0.0000000000000000000000000000000000000000000000005264 183.0
HKD2_k127_6858239_47 Transcriptional regulator K03719 - - 0.00000000000000000000000000000000000000000000001442 196.0
HKD2_k127_6858239_48 Secreted repeat of unknown function - - - 0.00000000000000000000000000000000000000000000003308 173.0
HKD2_k127_6858239_49 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.00000000000000000000000000000000000000000000004418 180.0
HKD2_k127_6858239_5 Tripartite tricarboxylate transporter TctA family K07793 - - 1.187e-215 680.0
HKD2_k127_6858239_50 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000000000000000002601 166.0
HKD2_k127_6858239_51 - - - - 0.000000000000000000000000000000000000000267 164.0
HKD2_k127_6858239_52 Domain of unknown function (DUF1924) - - - 0.000000000000000000000000000000000000001263 152.0
HKD2_k127_6858239_53 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02110 - - 0.0000000000000000000000000000000000001155 142.0
HKD2_k127_6858239_54 PFAM Sterol-binding domain protein K03690 - - 0.000000000000000000000000000000001111 141.0
HKD2_k127_6858239_55 Dihaem cytochrome c - - - 0.00000000000000000000000000000008487 136.0
HKD2_k127_6858239_56 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000001249 131.0
HKD2_k127_6858239_58 'Cold-shock' DNA-binding domain K03704 - - 0.00000000000000000000000002192 109.0
HKD2_k127_6858239_59 Could be involved in insertion of integral membrane proteins into the membrane K08998 - - 0.0000000000000000000000005258 109.0
HKD2_k127_6858239_6 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 1.359e-213 685.0
HKD2_k127_6858239_60 Tripartite tricarboxylate transporter TctB family K07794 - - 0.00000000000000000000000354 109.0
HKD2_k127_6858239_61 Universal stress protein - - - 0.0000000000000000000000404 106.0
HKD2_k127_6858239_62 ATP synthase I chain K02116 - - 0.00000000000000000002365 94.0
HKD2_k127_6858239_63 TonB family K03832 - - 0.0000000000000000001267 95.0
HKD2_k127_6858239_64 Helix-turn-helix XRE-family like proteins K07726 - - 0.00000000000000000169 88.0
HKD2_k127_6858239_65 Belongs to the bacterial ribosomal protein bL34 family K02914 - - 0.0000000000000001481 79.0
HKD2_k127_6858239_66 Belongs to the UPF0235 family K09131 - - 0.0000000000002448 82.0
HKD2_k127_6858239_67 - - - - 0.0000000000852 76.0
HKD2_k127_6858239_68 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme - - - 0.00000009107 60.0
HKD2_k127_6858239_69 Protein involved in outer membrane biogenesis - - - 0.000005681 59.0
HKD2_k127_6858239_7 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis K03688 - - 6.018e-206 652.0
HKD2_k127_6858239_8 Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins K03217 - - 1.538e-203 653.0
HKD2_k127_6858239_9 Sodium:solute symporter family K14392 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000975 619.0
HKD2_k127_6884995_0 transferase activity, transferring glycosyl groups K00754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001669 296.0
HKD2_k127_6884995_1 transferase activity, transferring glycosyl groups - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001023 290.0
HKD2_k127_6884995_2 Polysaccharide pyruvyl transferase - - - 0.000000001252 70.0
HKD2_k127_6896893_0 PFAM AMP-dependent synthetase and ligase K00666 - - 4.824e-266 830.0
HKD2_k127_6896893_1 Aminotransferase class-III K00819 - 2.6.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002112 505.0
HKD2_k127_6896893_2 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005662 486.0
HKD2_k127_6896893_3 Deacetylases including yeast histone deacetylase and acetoin utilization protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002437 421.0
HKD2_k127_6896893_4 PFAM Enoyl-CoA hydratase isomerase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006804 399.0
HKD2_k127_6896893_5 Uncharacterised 5xTM membrane BCR, YitT family COG1284 - - - 0.000000000000000000000000000000000000000000000000000000000000001055 239.0
HKD2_k127_6896893_6 Haem-degrading K11477 - - 0.0000000000000000000000000000000000000000000000000000001429 197.0
HKD2_k127_6896893_7 helix_turn_helix ASNC type - - - 0.000000000000000000000000000000000000000000004867 170.0
HKD2_k127_6896893_8 Conserved Protein - - - 0.0000000000000000000000000000000000000004065 158.0
HKD2_k127_7007810_0 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly K11942 GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 9.571e-312 966.0
HKD2_k127_7144219_0 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000006251 264.0
HKD2_k127_7144219_1 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000000002582 194.0
HKD2_k127_7144219_2 Protein of unknown function (DUF2938) - - - 0.00000000000000000000000000000000000000000000000000000387 194.0
HKD2_k127_7144219_3 PhoD-like phosphatase K01113 - 3.1.3.1 0.0000000000000000000000002226 122.0
HKD2_k127_7144219_4 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.00000000000000000007185 92.0
HKD2_k127_7144219_5 .,Oxidizes proline to glutamate for use as a carbon and nitrogen source - - - 0.00000000000002671 77.0
HKD2_k127_7175561_0 Hydantoinase B/oxoprolinase K01469 - 3.5.2.9 0.0 1770.0
HKD2_k127_7175561_1 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 4.525e-195 617.0
HKD2_k127_7175561_2 D-amino acid K00285 - 1.4.5.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001754 470.0
HKD2_k127_7175561_3 Bacterial extracellular solute-binding protein, family 7 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005971 428.0
HKD2_k127_7175561_4 Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate K01952 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006779 315.0
HKD2_k127_7175561_5 signal transduction protein containing EAL and modified HD-GYP domains - - - 0.000000000000000000000000000000000000000000000000000000000000000000002388 251.0
HKD2_k127_7175561_6 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758 - 4.2.1.136 0.0000000000000000000000000000000000000000000000000000000000000000001483 241.0
HKD2_k127_7175561_7 Tripartite ATP-independent periplasmic transporter DctQ component - - - 0.000000000000000000000000000000000000000004939 160.0
HKD2_k127_7193755_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.0 1523.0
HKD2_k127_7193755_1 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.0000000000000000000000000000000000000000000000000000000000000004633 223.0
HKD2_k127_7193755_2 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991,K12506 - 2.7.7.60,4.6.1.12 0.0000000000000000000000000000000000000000000000000000000003085 210.0
HKD2_k127_7193755_3 Protein of unknown function (DUF4241) - - - 0.0000000000000004305 86.0
HKD2_k127_7221822_0 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001814 327.0
HKD2_k127_7221822_2 - - - - 0.0000000000000003219 81.0
HKD2_k127_7221822_3 COG NOG14552 non supervised orthologous group - - - 0.00009202 45.0
HKD2_k127_7274587_0 PFAM glycosyl transferase family 39 - - - 0.000000000000000000000000000000000002015 152.0
HKD2_k127_7274587_1 Acid phosphatase homologues - - - 0.0000000000000000000000000000000002662 139.0
HKD2_k127_735606_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0 1440.0
HKD2_k127_735606_1 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 4.925e-261 824.0
HKD2_k127_735606_10 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released K03092 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007623 537.0
HKD2_k127_735606_11 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001003 509.0
HKD2_k127_735606_12 TIGRFAM 2-aminoethylphosphonate ABC transport system, 1-aminoethylphosphonate-binding protein component K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000908 496.0
HKD2_k127_735606_13 Ppx/GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 496.0
HKD2_k127_735606_14 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 434.0
HKD2_k127_735606_15 Thioredoxin-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003962 442.0
HKD2_k127_735606_16 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002099 423.0
HKD2_k127_735606_17 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity K06048 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001184 431.0
HKD2_k127_735606_18 ABC transporter K06861 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 394.0
HKD2_k127_735606_19 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 403.0
HKD2_k127_735606_2 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 2.631e-252 796.0
HKD2_k127_735606_20 A G-specific K03575 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000175 394.0
HKD2_k127_735606_21 Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) K06023 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006021 373.0
HKD2_k127_735606_22 Belongs to the ABC transporter superfamily K02010,K02052,K11072 - 3.6.3.30,3.6.3.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003769 347.0
HKD2_k127_735606_23 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates K10563 - 3.2.2.23,4.2.99.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000192 336.0
HKD2_k127_735606_24 Displays ATPase and GTPase activities K06958 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 334.0
HKD2_k127_735606_25 Esterase of the alpha-beta hydrolase superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002241 309.0
HKD2_k127_735606_26 FCD - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007354 297.0
HKD2_k127_735606_27 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate K00954 - 2.7.7.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007387 289.0
HKD2_k127_735606_28 MOSC N-terminal beta barrel domain K07140 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001837 282.0
HKD2_k127_735606_29 PFAM inositol monophosphatase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001526 279.0
HKD2_k127_735606_3 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 9.814e-251 779.0
HKD2_k127_735606_30 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol K00919 - 2.7.1.148 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002421 274.0
HKD2_k127_735606_31 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000001844 259.0
HKD2_k127_735606_32 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance K02897 - - 0.000000000000000000000000000000000000000000000000000000000000000000000005168 250.0
HKD2_k127_735606_33 Metal dependent phosphohydrolases with conserved 'HD' motif. K21196 - 1.13.11.78 0.00000000000000000000000000000000000000000000000000000000000000001078 231.0
HKD2_k127_735606_34 PFAM phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 K02806 - - 0.0000000000000000000000000000000000000000000000000000000000000001641 224.0
HKD2_k127_735606_35 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363 - 0.00000000000000000000000000000000000000000000000000000000000003115 220.0
HKD2_k127_735606_36 Sodium/hydrogen exchanger family - - - 0.0000000000000000000000000000000000000000000000000000000000000422 231.0
HKD2_k127_735606_37 - - - - 0.000000000000000000000000000000000000000000000000001194 193.0
HKD2_k127_735606_38 phosphohistidine phosphatase K08296 - - 0.00000000000000000000000000000000000000000000000003485 192.0
HKD2_k127_735606_39 PFAM peptidase S16 lon domain protein K07157 - - 0.000000000000000000000000000000000000000000000001613 183.0
HKD2_k127_735606_4 Dynamin family - - - 7.974e-197 634.0
HKD2_k127_735606_40 Methyltransferase K08316 - 2.1.1.171 0.00000000000000000000000000000000000000000000005864 190.0
HKD2_k127_735606_41 haloacid dehalogenase-like hydrolase K03270 - 3.1.3.45 0.0000000000000000000000000000000000000000002084 173.0
HKD2_k127_735606_42 Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane K09774 - - 0.000000000000000000000000000000000000000004445 168.0
HKD2_k127_735606_43 cell division ATP-binding protein FtsE K09812 - - 0.00000000000000000000000000000000000000001015 162.0
HKD2_k127_735606_44 Protein of unknown function (DUF418) K07148 - - 0.00000000000000000000000000000000000000009671 166.0
HKD2_k127_735606_45 Acetyltransferase (GNAT) family - - - 0.000000000000000000000000000000000000002239 159.0
HKD2_k127_735606_46 PFAM Acetyltransferase (GNAT) family K00657 - 2.3.1.57 0.0000000000000000000000000000000000003657 147.0
HKD2_k127_735606_47 seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing K05808 - - 0.000000000000000000000000000000000802 136.0
HKD2_k127_735606_48 Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein K02494 - - 0.000000000000000000002358 108.0
HKD2_k127_735606_49 EamA-like transporter family - - - 0.000000048 55.0
HKD2_k127_735606_5 binding-protein-dependent transport systems inner membrane component K02011 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006417 616.0
HKD2_k127_735606_50 Part of the ABC transporter FtsEX involved in cellular division K09811 - - 0.00000007391 63.0
HKD2_k127_735606_52 - - - - 0.0001315 44.0
HKD2_k127_735606_53 Lipopolysaccharide-assembly, LptC-related K11719 - - 0.0005063 50.0
HKD2_k127_735606_6 PFAM type I phosphodiesterase nucleotide pyrophosphatase K19670 - 3.11.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 613.0
HKD2_k127_735606_7 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006231 578.0
HKD2_k127_735606_8 Na Pi-cotransporter II-related protein K03324 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001826 583.0
HKD2_k127_735606_9 Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily K03430 - 2.6.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007525 578.0
HKD2_k127_739902_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1598.0
HKD2_k127_739902_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K07798,K15727 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 527.0
HKD2_k127_739902_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001168 482.0
HKD2_k127_739902_3 PFAM FAD dependent oxidoreductase K00285 - 1.4.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000201 353.0
HKD2_k127_739902_4 COG1538 Outer membrane protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 327.0
HKD2_k127_739902_5 COG2010 Cytochrome c, mono- and diheme variants - - - 0.00000000000000000000000000000000000000000002291 166.0
HKD2_k127_739902_6 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein K03611 - - 0.0000000000000000000000000304 124.0
HKD2_k127_739902_7 PFAM Copper binding periplasmic protein CusF - - - 0.0000000000000000007202 92.0
HKD2_k127_7459360_0 Domain of unknown function (DUF3458_C) ARM repeats K01256 - 3.4.11.2 0.0 1046.0
HKD2_k127_7459360_1 COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component - - - 5.602e-256 802.0
HKD2_k127_7459360_10 Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000562 502.0
HKD2_k127_7459360_11 Belongs to the FBPase class 1 family K03841 - 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002457 510.0
HKD2_k127_7459360_12 TIGRFAM TRAP dicarboxylate transporter, DctP subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005895 484.0
HKD2_k127_7459360_13 NADPH quinone reductase and related Zn-dependent oxidoreductases K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001471 466.0
HKD2_k127_7459360_14 Peptidogalycan biosysnthesis/recognition K09919 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001113 465.0
HKD2_k127_7459360_15 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis K00059 GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000683 400.0
HKD2_k127_7459360_16 TAP-like protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005948 398.0
HKD2_k127_7459360_17 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 - 2.5.1.61 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007212 378.0
HKD2_k127_7459360_18 Belongs to the pirin family K06911 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 378.0
HKD2_k127_7459360_19 Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon K01894 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000506 358.0
HKD2_k127_7459360_2 belongs to the aldehyde dehydrogenase family K00128 - 1.2.1.3 1.063e-231 736.0
HKD2_k127_7459360_20 Molybdenum cofactor biosynthesis protein MogA K03831 - 2.7.7.75 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007615 322.0
HKD2_k127_7459360_21 of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003083 312.0
HKD2_k127_7459360_22 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions K01507 - 3.6.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002853 297.0
HKD2_k127_7459360_23 ABC-2 family transporter protein K09696 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006675 292.0
HKD2_k127_7459360_24 EamA-like transporter family K15268 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003281 282.0
HKD2_k127_7459360_25 Serine hydrolase (FSH1) K06999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005231 285.0
HKD2_k127_7459360_26 formate dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001241 289.0
HKD2_k127_7459360_27 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002584 277.0
HKD2_k127_7459360_28 LytTr DNA-binding domain K08083 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002879 272.0
HKD2_k127_7459360_29 ATPase MipZ K03496 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003056 274.0
HKD2_k127_7459360_3 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01916,K01950 - 6.3.1.5,6.3.5.1 3.362e-219 694.0
HKD2_k127_7459360_30 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000004655 287.0
HKD2_k127_7459360_31 denitrification pathway K15876 GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001195 277.0
HKD2_k127_7459360_32 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000002679 268.0
HKD2_k127_7459360_33 ABC transporter K09697 - 3.6.3.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000304 269.0
HKD2_k127_7459360_34 UPF0126 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001671 250.0
HKD2_k127_7459360_35 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000000001909 240.0
HKD2_k127_7459360_36 Histidine kinase K08082 - 2.7.13.3 0.000000000000000000000000000000000000000000000000000000000000000003831 238.0
HKD2_k127_7459360_37 HemY protein N-terminus K02498 - - 0.000000000000000000000000000000000000000000000000000000000000000003862 250.0
HKD2_k127_7459360_38 Smr protein MutS2 - - - 0.0000000000000000000000000000000000000000000000000000000000000005246 228.0
HKD2_k127_7459360_39 Diguanylate cyclase phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000003243 222.0
HKD2_k127_7459360_4 Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family K03455 - - 3.36e-211 670.0
HKD2_k127_7459360_40 Nitrogen regulatory protein P-II K04751,K04752 - - 0.00000000000000000000000000000000000000000000000000000004275 197.0
HKD2_k127_7459360_41 HemX, putative uroporphyrinogen-III C-methyltransferase K02496,K13543 - 2.1.1.107,4.2.1.75 0.000000000000000000000000000000000000000000000000001393 197.0
HKD2_k127_7459360_42 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.00000000000000000000000000000000000000000000000004947 187.0
HKD2_k127_7459360_43 Haem-degrading - - - 0.000000000000000000000000000000000000000000000003574 181.0
HKD2_k127_7459360_44 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000002025 196.0
HKD2_k127_7459360_45 PFAM DoxX family protein K15977 - - 0.0000000000000000000000000000000000000000004106 161.0
HKD2_k127_7459360_46 Protein tyrosine kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000001344 175.0
HKD2_k127_7459360_47 Belongs to the UPF0307 family K09889 - - 0.000000000000000000000000000000000000001588 153.0
HKD2_k127_7459360_48 Protein of unknown function (DUF423) - - - 0.0000000000000000000000000000000001882 147.0
HKD2_k127_7459360_49 Uroporphyrinogen-III synthase HemD - - - 0.000000000000000000000000000001105 139.0
HKD2_k127_7459360_5 argininosuccinate lyase K01755 - 4.3.2.1 9.643e-211 664.0
HKD2_k127_7459360_50 PFAM small multidrug resistance protein K11741 - - 0.000000000000000000000000000004136 123.0
HKD2_k127_7459360_6 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001467 612.0
HKD2_k127_7459360_7 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002933 607.0
HKD2_k127_7459360_8 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002217 609.0
HKD2_k127_7459360_9 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004219 505.0
HKD2_k127_7472008_0 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004475 476.0
HKD2_k127_7472008_1 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00346 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000161 475.0
HKD2_k127_7472008_2 cyclic nucleotide binding K10914 - - 0.0000000000000000000000000000003572 130.0
HKD2_k127_7472008_3 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol K00348 - 1.6.5.8 0.00000000000000000000004015 105.0
HKD2_k127_7472008_4 Major Facilitator Superfamily - - - 0.000000000000006692 81.0
HKD2_k127_7502113_0 Transglycosylase SLT domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004678 613.0
HKD2_k127_7502113_1 ATPase family associated with various cellular activities (AAA) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 505.0
HKD2_k127_7502113_2 Ribulose bisphosphate carboxylase large chain, catalytic domain K01601 - 4.1.1.39 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009636 320.0
HKD2_k127_7502113_3 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA K03439 - 2.1.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000002491 246.0
HKD2_k127_7502113_4 Cupin 2, conserved barrel domain protein K00450,K00971,K09988,K11312 - 1.13.11.4,2.7.7.13,5.3.1.15 0.0000000000000000000000000000000000000000000001019 187.0
HKD2_k127_7545662_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 6.789e-286 895.0
HKD2_k127_7545662_1 Amino acid amide ABC transporter substrate-binding protein, HAAT family K01999 - - 4.135e-208 657.0
HKD2_k127_7545662_10 Membrane transport protein K07088 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005569 392.0
HKD2_k127_7545662_11 mannose-ethanolamine phosphotransferase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003867 382.0
HKD2_k127_7545662_12 Aldo keto K00011 - 1.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003443 360.0
HKD2_k127_7545662_13 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 339.0
HKD2_k127_7545662_14 pyrroloquinoline quinone binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009085 330.0
HKD2_k127_7545662_15 Cyclic nucleotide-binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001069 284.0
HKD2_k127_7545662_16 Cytochrome c - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001765 243.0
HKD2_k127_7545662_17 glyoxalase bleomycin resistance protein dioxygenase K06991 - - 0.0000000000000000000000000000000000000000000000000000000000000000005099 241.0
HKD2_k127_7545662_18 3-demethylubiquinone-9 3-methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000115 228.0
HKD2_k127_7545662_19 - - - - 0.000000000000000000000000000000000000000000000000000000000000009262 221.0
HKD2_k127_7545662_2 protein related to plant photosystem II stability assembly factor - - - 3.648e-202 647.0
HKD2_k127_7545662_20 dithiol-disulfide isomerase involved in polyketide biosynthesis - - - 0.00000000000000000000000000000000000000000000000000000003463 203.0
HKD2_k127_7545662_21 Haem-binding uptake, Tiki superfamily, ChaN - - - 0.000000000000000000000000000000000000000000000000000003032 206.0
HKD2_k127_7545662_22 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000000006736 201.0
HKD2_k127_7545662_23 ThiS family K03636 - - 0.00000000000000000000000000001494 122.0
HKD2_k127_7545662_24 MarR family - - - 0.000000000000000002464 92.0
HKD2_k127_7545662_25 Domain of unknown function (DUF4440) - - - 0.00000000000002673 83.0
HKD2_k127_7545662_26 3-Demethylubiquinone-9 3-methyltransferase K04750 - - 0.00000001899 57.0
HKD2_k127_7545662_27 PFAM ABC transporter related K01996 - - 0.0000001592 61.0
HKD2_k127_7545662_3 Major Facilitator - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000379 535.0
HKD2_k127_7545662_4 Transmembrane secretion effector - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 529.0
HKD2_k127_7545662_5 6-O-methylguanine DNA methyltransferase, DNA binding domain K00567,K10778 GO:0001130,GO:0003674,GO:0003700,GO:0003824,GO:0003908,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006355,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016740,GO:0016741,GO:0018125,GO:0018193,GO:0018198,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044728,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0046872,GO:0046914,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070988,GO:0071704,GO:0080090,GO:0080111,GO:0090304,GO:0140110,GO:1901360,GO:1901564,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 2.1.1.63 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003138 517.0
HKD2_k127_7545662_6 Belongs to the binding-protein-dependent transport system permease family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003473 518.0
HKD2_k127_7545662_7 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 438.0
HKD2_k127_7545662_8 ABC-type branched-chain amino acid transport systems ATPase component K01995 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000125 424.0
HKD2_k127_7545662_9 PFAM glutaredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000274 414.0
HKD2_k127_7631834_0 CBS domain containing protein K06189 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003639 389.0
HKD2_k127_7631834_1 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000028 322.0
HKD2_k127_7631834_2 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.000000000000000000000000000000000000001444 150.0
HKD2_k127_7631834_3 Transfers the fatty acyl group on membrane lipoproteins K03820 - - 0.00000000000000000000000000000000003764 141.0
HKD2_k127_7671891_0 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005249 474.0
HKD2_k127_7671891_1 Glycosyltransferase family 9 (heptosyltransferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007861 477.0
HKD2_k127_7671891_2 HAD-hyrolase-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005051 319.0
HKD2_k127_7671891_3 KR domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000669 317.0
HKD2_k127_7674327_0 Phosphomethylpyrimidine kinase K00941 - 2.7.1.49,2.7.4.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007351 385.0
HKD2_k127_7674327_1 Bacterial transcriptional repressor C-terminal K09017 - - 0.0000000000000000000000000000000000000000000000000000000000000000002508 238.0
HKD2_k127_7684187_0 FAD linked oxidase domain protein - - - 0.0 1993.0
HKD2_k127_7684187_1 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 4.65e-233 731.0
HKD2_k127_7684187_10 HIT domain - - - 0.0000000000000000000000000000000000000000000008968 174.0
HKD2_k127_7684187_11 Uncharacterized protein family, UPF0114 - - - 0.00000000000000000000000000000000000000003005 158.0
HKD2_k127_7684187_12 Biotin protein ligase C terminal domain K03524 - 6.3.4.15 0.000000000000000000000000000000000000004364 157.0
HKD2_k127_7684187_13 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K01947,K03525 - 2.7.1.33,6.3.4.15 0.0000000000000000000000000000000000002599 151.0
HKD2_k127_7684187_14 Belongs to the UPF0250 family K09158 - - 0.00000000000000000000000000000004846 127.0
HKD2_k127_7684187_15 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000001943 117.0
HKD2_k127_7684187_16 Sporulation related domain - - - 0.00000000000009099 80.0
HKD2_k127_7684187_17 - - - - 0.000000002229 65.0
HKD2_k127_7684187_2 A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005446 461.0
HKD2_k127_7684187_3 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001065 350.0
HKD2_k127_7684187_4 Belongs to the peptidase S11 family K01286,K07258 - 3.4.16.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008569 357.0
HKD2_k127_7684187_5 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase K00824 - 2.6.1.21 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007253 300.0
HKD2_k127_7684187_6 VanZ like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003876 298.0
HKD2_k127_7684187_7 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 285.0
HKD2_k127_7684187_8 Serine aminopeptidase, S33 K07018 - - 0.00000000000000000000000000000000000000000000000000000000000000299 229.0
HKD2_k127_7684187_9 Ferredoxin - - - 0.0000000000000000000000000000000000000000000001028 169.0
HKD2_k127_7691708_0 Glycolate oxidase subunit GlcD K00104 - 1.1.3.15 1.232e-233 734.0
HKD2_k127_7691708_1 Glycolate oxidase, iron-sulfur subunit K11473 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002827 589.0
HKD2_k127_7691708_10 regulator - - - 0.00000000000001055 81.0
HKD2_k127_7691708_11 - - - - 0.00000000005943 69.0
HKD2_k127_7691708_12 Platelet-activating factor acetylhydrolase plasma intracellular isoform II - - - 0.0001941 54.0
HKD2_k127_7691708_2 FAD binding domain K11472 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001163 430.0
HKD2_k127_7691708_3 Platelet-activating factor acetylhydrolase plasma intracellular isoform II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001841 396.0
HKD2_k127_7691708_4 PFAM LrgB family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007895 305.0
HKD2_k127_7691708_5 Nicotinamidase K08281 - 3.5.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000008034 283.0
HKD2_k127_7691708_6 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane K00325 - 1.6.1.2 0.0000000000000000000000000000000000000000000000000000003755 194.0
HKD2_k127_7691708_7 LrgA family K06518 - - 0.0000000000000000000000000000008809 128.0
HKD2_k127_7691708_8 Mitomycin resistance protein K07343 - - 0.00000000000000000000000004825 115.0
HKD2_k127_7691708_9 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - 0.000000000000000000000002494 103.0
HKD2_k127_7693808_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006262 566.0
HKD2_k127_7693808_1 Integral membrane protein TerC family K05794 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000584 477.0
HKD2_k127_7693808_2 Predicted permease YjgP/YjgQ family K11720 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000697 355.0
HKD2_k127_7693808_3 Permease YjgP YjgQ family K07091 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003066 339.0
HKD2_k127_7693808_4 - - - - 0.000000000000000000000000000000000000000000000001429 194.0
HKD2_k127_7693808_5 DNA polymerase III (Chi subunit) K02339 - 2.7.7.7 0.000000000000000000000000005615 114.0
HKD2_k127_7693808_6 phosphinothricin N-acetyltransferase activity K03823,K06718 - 2.3.1.178,2.3.1.183 0.00000000000003115 77.0
HKD2_k127_7703025_0 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.4 1.171e-218 691.0
HKD2_k127_7703025_1 Hydroxymethylglutaryl-CoA lyase K01640 GO:0000287,GO:0003674,GO:0003824,GO:0004419,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005782,GO:0005829,GO:0006082,GO:0006091,GO:0006520,GO:0006551,GO:0006552,GO:0006605,GO:0006625,GO:0006629,GO:0006807,GO:0006810,GO:0006886,GO:0006996,GO:0007031,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009081,GO:0009083,GO:0009987,GO:0015031,GO:0015833,GO:0016043,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0017144,GO:0019752,GO:0022607,GO:0030145,GO:0031907,GO:0031974,GO:0033036,GO:0033365,GO:0034613,GO:0042579,GO:0042802,GO:0042803,GO:0042886,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045184,GO:0046395,GO:0046872,GO:0046907,GO:0046914,GO:0046950,GO:0046951,GO:0046983,GO:0051179,GO:0051234,GO:0051259,GO:0051262,GO:0051641,GO:0051649,GO:0065003,GO:0070013,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:1901564,GO:1901565,GO:1901568,GO:1901570,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902224 4.1.3.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002274 435.0
HKD2_k127_7703025_10 Neisseria PilC beta-propeller domain K02674 - - 0.00000001441 66.0
HKD2_k127_7703025_2 PFAM D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K12972 - 1.1.1.79,1.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001595 276.0
HKD2_k127_7703025_3 Type IV Pilus-assembly protein W K02672 - - 0.00000000000000000000000000000000000000000000000000000004241 212.0
HKD2_k127_7703025_4 - - - - 0.000000000000000000000000000000000000000000000492 189.0
HKD2_k127_7703025_5 type IV pilus assembly protein PilV K02671 - - 0.000000000000000000000000000001469 132.0
HKD2_k127_7703025_6 Type IV pilus assembly protein PilE K02655 - - 0.000000000000000000000000000006673 124.0
HKD2_k127_7703025_7 Type II transport protein GspH K08084 - - 0.00000000000000000003374 96.0
HKD2_k127_7703025_9 Pilus assembly protein PilX - - - 0.00000000000000004671 95.0
HKD2_k127_7705451_0 oxidoreductase activity - - - 0.0 1056.0
HKD2_k127_7705451_1 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein K00341 - 1.6.5.3 9.487e-303 942.0
HKD2_k127_7705451_2 Catalyzes the transfer of electrons from NADH to quinone K00342 - 1.6.5.3 7.017e-241 753.0
HKD2_k127_7705451_3 alcohol dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008736 587.0
HKD2_k127_7705451_4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 585.0
HKD2_k127_7705451_5 NUDIX domain K01515 - 3.6.1.13 0.0000000000000000000000000000000000000000000000000000000000000000009552 232.0
HKD2_k127_7705451_6 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000006404 209.0
HKD2_k127_7705451_7 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340 - 1.6.5.3 0.00000000000000000000000000000000000000133 158.0
HKD2_k127_7705451_8 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338 - 1.6.5.3 0.00000000008011 62.0
HKD2_k127_7706068_0 Polysaccharide biosynthesis protein K02473 - 5.1.3.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000177 531.0
HKD2_k127_7706068_1 UDP binding domain K02474 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001165 377.0
HKD2_k127_771210_0 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000008226 246.0
HKD2_k127_771210_1 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template K03628 - - 0.00000000000000000000000000000000000000000000000000000000000000001062 225.0
HKD2_k127_771210_2 Belongs to the GARS family K01945 - 6.3.4.13 0.000000003721 57.0
HKD2_k127_7722613_0 Arginyl-tRNA synthetase K01887 - 6.1.1.19 5.51e-236 747.0
HKD2_k127_7722613_1 DNA helicase K03654 - 3.6.4.12 4.494e-223 716.0
HKD2_k127_7722613_10 Belongs to the short-chain dehydrogenases reductases (SDR) family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007485 308.0
HKD2_k127_7722613_11 DNA polymerase K02347 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004733 309.0
HKD2_k127_7722613_12 PFAM Phosphatidylethanolamine-binding protein K06910 - - 0.0000000000000000000000000000000000000000000000000000000000000003212 224.0
HKD2_k127_7722613_13 CBS domain - - - 0.0000000000000000000000000000000000000000000000000000000000000008455 225.0
HKD2_k127_7722613_14 Thiol disulfide interchange protein K03673 - - 0.00000000000000000000000000000000000000000000000000000000007702 211.0
HKD2_k127_7722613_15 Lysine exporter protein (Lyse ygga) - - - 0.000000000000000000000000000000000000000000000000000000732 206.0
HKD2_k127_7722613_16 Thioesterase superfamily - - - 0.000000000000000000000000000000000000000000000000002911 186.0
HKD2_k127_7722613_17 helix_turn_helix, mercury resistance - - - 0.000000000000000000000000000000000000000000000000004582 185.0
HKD2_k127_7722613_18 cell division protein - - - 0.0000000000000000000000000000000000286 141.0
HKD2_k127_7722613_19 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000009651 137.0
HKD2_k127_7722613_2 Acyl-CoA dehydrogenase, C-terminal domain K00253 - 1.3.8.4 3.062e-220 686.0
HKD2_k127_7722613_20 PFAM CBS domain containing protein - - - 0.0000000000000000000000000000001366 129.0
HKD2_k127_7722613_21 GMC oxidoreductase K03333 - 1.1.3.6 0.000000000000000000000000004803 112.0
HKD2_k127_7722613_22 Protein of unknown function (DUF2799) - - - 0.00000000000000000000000001103 119.0
HKD2_k127_7722613_23 membrane - - - 0.00000000002721 76.0
HKD2_k127_7722613_3 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation K00906 - 2.7.11.5 8.46e-213 676.0
HKD2_k127_7722613_4 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K01426 - 3.5.1.4 3.392e-210 663.0
HKD2_k127_7722613_5 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 531.0
HKD2_k127_7722613_6 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009602 451.0
HKD2_k127_7722613_7 Zn-dependent hydrolases including glyoxylases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004193 436.0
HKD2_k127_7722613_8 Cys/Met metabolism PLP-dependent enzyme K01760 GO:0000096,GO:0000098,GO:0000724,GO:0000725,GO:0003674,GO:0003824,GO:0004121,GO:0006082,GO:0006090,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006520,GO:0006534,GO:0006725,GO:0006790,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009093,GO:0009987,GO:0016054,GO:0016829,GO:0016846,GO:0019448,GO:0019450,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044273,GO:0044281,GO:0044282,GO:0046395,GO:0046439,GO:0046483,GO:0047804,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1990414 4.4.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005727 426.0
HKD2_k127_7722613_9 SMART Extracellular solute-binding protein, family 3 K02030 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000507 322.0
HKD2_k127_7736610_0 Ferredoxin--NADP reductase K00384 - 1.8.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004529 605.0
HKD2_k127_7736610_1 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003208 553.0
HKD2_k127_7736610_10 Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) K03637 - 4.6.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000001238 245.0
HKD2_k127_7736610_11 Prolyl oligopeptidase K01322 - 3.4.21.26 0.0000000000000000000000000000000000000000000000000000000000000000009552 232.0
HKD2_k127_7736610_12 Protein of unknown function (DUF2946) - - - 0.000000000000000000000000000000000000000005346 164.0
HKD2_k127_7736610_13 SnoaL-like domain - - - 0.00000000000000000000000000000001204 138.0
HKD2_k127_7736610_14 Belongs to the IlvD Edd family K13875 - 4.2.1.25 0.0000000000000000000000000000001501 124.0
HKD2_k127_7736610_15 Zinc-finger domain - - - 0.00000000000000000000997 106.0
HKD2_k127_7736610_2 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009627 510.0
HKD2_k127_7736610_3 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002732 467.0
HKD2_k127_7736610_4 Peptidase family M48 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008514 452.0
HKD2_k127_7736610_5 Belongs to the LDH2 MDH2 oxidoreductase family K00016 - 1.1.1.27 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008223 398.0
HKD2_k127_7736610_6 alpha/beta hydrolase fold K07019 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001885 393.0
HKD2_k127_7736610_7 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP K00858 - 2.7.1.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007285 341.0
HKD2_k127_7736610_8 KR domain K21883 - 1.1.1.401 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003439 332.0
HKD2_k127_7736610_9 Ornithine cyclodeaminase/mu-crystallin family K01750 - 4.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005925 285.0
HKD2_k127_7738001_0 Bacterial regulatory helix-turn-helix protein, lysR family K03717 - - 0.0000000000000000000000000000000000000000000000000000000000003048 217.0
HKD2_k127_7738001_1 NADP oxidoreductase coenzyme F420-dependent K06988 - 1.5.1.40 0.000000000000000000000000000000000000000000000000000000007165 200.0
HKD2_k127_7738001_2 membrane protein, TerC K05794 - - 0.00000000000000000000000000000000000000000009801 161.0
HKD2_k127_7738001_3 Sigma 54 modulation protein / S30EA ribosomal protein - - - 0.000000000000000000009551 104.0
HKD2_k127_7747515_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 2.052e-232 729.0
HKD2_k127_7747515_1 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases K00174 - 1.2.7.11,1.2.7.3 9.828e-224 710.0
HKD2_k127_7747515_2 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001185 564.0
HKD2_k127_7747515_3 2 iron, 2 sulfur cluster binding K00266,K00528,K02823 - 1.18.1.2,1.19.1.1,1.4.1.13,1.4.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001884 459.0
HKD2_k127_7747515_4 COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000827 329.0
HKD2_k127_7747515_5 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 0.0000000000000000001947 88.0
HKD2_k127_7764167_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 5.125e-238 750.0
HKD2_k127_7764167_1 PFAM Acyl-CoA dehydrogenase K00252 - 1.3.8.6 7.586e-225 700.0
HKD2_k127_7764167_10 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) K01588 - 5.4.99.18 0.0000000000000000000000000000000000000000000000000000000000000000000000001943 250.0
HKD2_k127_7764167_11 lipase activity - - - 0.0000000000000000000000000000000000000000000000000001437 199.0
HKD2_k127_7764167_12 COG0604 NADPH quinone reductase and related Zn-dependent - - - 0.000000000000000000000000000000000002948 149.0
HKD2_k127_7764167_13 Short repeat of unknown function (DUF308) - - - 0.000000000000000000000000000000006089 135.0
HKD2_k127_7764167_14 Recycling of diacylglycerol produced during the turnover of membrane phospholipid K00901 - 2.7.1.107 0.0000000000000000000000000000047 123.0
HKD2_k127_7764167_2 Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively K01556 - 3.7.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000671 481.0
HKD2_k127_7764167_3 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) K01589 - 6.3.4.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008425 463.0
HKD2_k127_7764167_4 phosphoribosylaminoimidazolesuccinocarboxamide synthase K01923 GO:0003674,GO:0003824,GO:0004639,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006742 441.0
HKD2_k127_7764167_5 Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety K00453 GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009435,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019441,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0020037,GO:0022607,GO:0034641,GO:0034654,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0046906,GO:0048037,GO:0051186,GO:0051188,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 1.13.11.11 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003718 401.0
HKD2_k127_7764167_6 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 334.0
HKD2_k127_7764167_7 Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation K07130 GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004819 291.0
HKD2_k127_7764167_8 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006012 289.0
HKD2_k127_7764167_9 Alpha beta hydrolase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001324 278.0
HKD2_k127_7776999_0 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01703 - 4.2.1.33,4.2.1.35 3.314e-255 793.0
HKD2_k127_7776999_1 Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB K04044 - - 4.939e-253 797.0
HKD2_k127_7776999_10 Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide K01739,K10764 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006633 527.0
HKD2_k127_7776999_11 Malic enzyme, NAD binding domain K00029 - 1.1.1.40 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004289 495.0
HKD2_k127_7776999_12 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003945 481.0
HKD2_k127_7776999_13 LysM domain K08086 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003338 463.0
HKD2_k127_7776999_14 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005516 370.0
HKD2_k127_7776999_15 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate K01704 - 4.2.1.33,4.2.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 350.0
HKD2_k127_7776999_16 Patatin-like phospholipase K07001 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003414 330.0
HKD2_k127_7776999_17 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000825 312.0
HKD2_k127_7776999_18 Zn-dependent protease with chaperone function K07387 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003556 309.0
HKD2_k127_7776999_19 Nucleoside H+ symporter K05820 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004747 297.0
HKD2_k127_7776999_2 Glycerol acyltransferase K05939 - 2.3.1.40,6.2.1.20 1.362e-249 785.0
HKD2_k127_7776999_20 A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters K04488 - - 0.0000000000000000000000000000000000000000000000000000000000000000000003663 239.0
HKD2_k127_7776999_21 Iron-sulfur cluster assembly transcription factor K13643 - - 0.000000000000000000000000000000000000000000000000000000000000000000002306 239.0
HKD2_k127_7776999_22 Belongs to the TrpF family K01817 - 5.3.1.24 0.00000000000000000000000000000000000000000000000000000000000000141 233.0
HKD2_k127_7776999_23 Belongs to the HesB IscA family K13628 - - 0.0000000000000000000000000000000000000000000000000003825 185.0
HKD2_k127_7776999_24 Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA K04082 - - 0.00000000000000000000000000000000000000000000005348 177.0
HKD2_k127_7776999_25 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000247 183.0
HKD2_k127_7776999_26 Ferredoxin, 2Fe-2S type, ISC system K04755 - - 0.00000000000000000000000000000000000000000000803 168.0
HKD2_k127_7776999_27 protocatechuate 3,4-dioxygenase K00449 - 1.13.11.3 0.000000000000000000000000000000000000000002135 163.0
HKD2_k127_7776999_28 Iron-sulphur cluster assembly - - - 0.00000000000000000000000002844 110.0
HKD2_k127_7776999_29 Sporulation related domain K03749 - - 0.00000000000000000001154 101.0
HKD2_k127_7776999_3 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine K00764 - 2.4.2.14 1.1e-248 775.0
HKD2_k127_7776999_30 colicin v production K03558 - - 0.0000000000001936 76.0
HKD2_k127_7776999_31 Entericidin EcnA/B family - - - 0.00002902 50.0
HKD2_k127_7776999_4 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 3.711e-229 716.0
HKD2_k127_7776999_5 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 1.574e-220 688.0
HKD2_k127_7776999_6 Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate K00052 GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001824 604.0
HKD2_k127_7776999_7 Belongs to the folylpolyglutamate synthase family K11754 - 6.3.2.12,6.3.2.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003502 585.0
HKD2_k127_7776999_8 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate K00133 - 1.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006609 566.0
HKD2_k127_7776999_9 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 - 4.2.3.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008532 569.0
HKD2_k127_7822709_0 AcrB/AcrD/AcrF family - - - 0.0 1325.0
HKD2_k127_7822709_1 sulfite reductase, dissimilatory-type alpha subunit K11180 - 1.8.99.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008541 606.0
HKD2_k127_7822709_10 Cas6 Crispr - - - 0.00000000000000000000000000000000000000004499 160.0
HKD2_k127_7822709_11 DsrC like protein K11179 - - 0.0000000000000000000000000000000000000000481 153.0
HKD2_k127_7822709_12 - - - - 0.0000000000000000000000000000000000000002896 158.0
HKD2_k127_7822709_13 Peptidase C14 caspase catalytic subunit p20 - - - 0.00000000000000000000000000000000006938 154.0
HKD2_k127_7822709_14 - - - - 0.000000000000000000000000000000005909 136.0
HKD2_k127_7822709_15 Protein of unknown function (DUF2892) - - - 0.00000000000000000000000000001395 118.0
HKD2_k127_7822709_16 - - - - 0.000000000000000000000000001456 122.0
HKD2_k127_7822709_17 - - - - 0.00000000000000000002015 94.0
HKD2_k127_7822709_18 Metal-sensitive transcriptional repressor K21600 - - 0.00000000000000003315 85.0
HKD2_k127_7822709_19 - - - - 0.00000000000000006866 96.0
HKD2_k127_7822709_2 Patatin-like phospholipase K07001 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004108 417.0
HKD2_k127_7822709_21 Peptidoglycan-binding domain 1 protein - - - 0.0000001131 57.0
HKD2_k127_7822709_3 competence protein COMEC - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008953 375.0
HKD2_k127_7822709_4 Taurine catabolism dioxygenase TauD, TfdA family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001756 334.0
HKD2_k127_7822709_5 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 323.0
HKD2_k127_7822709_6 Astacin (Peptidase family M12A) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000004532 285.0
HKD2_k127_7822709_7 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000005569 258.0
HKD2_k127_7822709_8 Transcriptional regulator K05798 - - 0.0000000000000000000000000000000000000000000009898 177.0
HKD2_k127_7822709_9 Sulfurtransferase TusA - - - 0.000000000000000000000000000000000000000000001571 172.0
HKD2_k127_7835835_0 The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis K00758 - 2.4.2.4 2.359e-228 719.0
HKD2_k127_7835835_1 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002342 599.0
HKD2_k127_7835835_10 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000000000000000008753 119.0
HKD2_k127_7835835_11 OmpA-like transmembrane domain K03286 - - 0.00000000000001387 82.0
HKD2_k127_7835835_12 - - - - 0.00000000001075 78.0
HKD2_k127_7835835_13 PFAM Spore coat protein U - - - 0.000000004959 64.0
HKD2_k127_7835835_2 RNA-metabolising metallo-beta-lactamase K07576 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001832 469.0
HKD2_k127_7835835_3 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000518 311.0
HKD2_k127_7835835_4 Belongs to the ribose-phosphate pyrophosphokinase family K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001167 311.0
HKD2_k127_7835835_5 CHAD domain - - - 0.0000000000000000000000000000000000000000000000000000000007168 221.0
HKD2_k127_7835835_6 Polyketide cyclase / dehydrase and lipid transport - - - 0.0000000000000000000000000000000000000000000000000000007441 198.0
HKD2_k127_7835835_7 HNH endonuclease - - - 0.000000000000000000000000000000000000000000000001282 186.0
HKD2_k127_7835835_8 SWI complex, BAF60b domains - - - 0.00000000000000000000000000000000000008195 146.0
HKD2_k127_7835835_9 Outer membrane usher protein K07347 - - 0.00000000000000000000000000000000000009944 156.0
HKD2_k127_7890985_0 Iron-sulfur cluster-binding domain K06871 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002595 522.0
HKD2_k127_7890985_1 PFAM phosphate acetyl butaryl transferase K00625 - 2.3.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 470.0
HKD2_k127_7890985_2 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 - 2.7.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002848 443.0
HKD2_k127_7890985_3 Poly-beta-hydroxybutyrate polymerase N terminal K03821 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 409.0
HKD2_k127_7890985_4 Belongs to the UPF0271 (lamB) family K07160 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002798 331.0
HKD2_k127_7890985_5 Allophanate hydrolase subunit 2 K06350 - - 0.000000000000000000000000000000000000000000000000000000000000000000000103 257.0
HKD2_k127_7890985_6 Cupin domain - - - 0.00000000000000000000000000000000000000000000000000000000101 203.0
HKD2_k127_7890985_7 Allophanate hydrolase subunit 1 K06351 - - 0.0000000000000000000000000000000000000000000000007584 184.0
HKD2_k127_7906827_0 Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed K00626 - 2.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000165 461.0
HKD2_k127_7906827_1 Bacterial regulatory proteins, tetR family - - - 0.000000000000000000000000004171 114.0
HKD2_k127_7906827_2 COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) K00059 - 1.1.1.100 0.000000001211 60.0
HKD2_k127_7931193_0 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000616 518.0
HKD2_k127_7931193_1 Predicted metal-binding integral membrane protein (DUF2182) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003951 276.0
HKD2_k127_7931193_2 Protein of unknown function (DUF1326) - - - 0.0000000000000000000003616 97.0
HKD2_k127_7931193_3 - - - - 0.00000000000002561 84.0
HKD2_k127_7944212_0 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 3.006e-204 644.0
HKD2_k127_7944212_1 Domain of unknown function DUF21 K03699 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001078 557.0
HKD2_k127_7944212_10 Tripartite ATP-independent periplasmic transporters, DctQ component - - - 0.000000000000000000000000000000000000000000000000000000213 201.0
HKD2_k127_7944212_11 Belongs to the CinA family K03743 - 3.5.1.42 0.000000000000000000000000000000000000000000001344 172.0
HKD2_k127_7944212_12 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons K03625 - - 0.00000000000000000000000000000000000000000001198 170.0
HKD2_k127_7944212_13 Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) K01095 - 3.1.3.27 0.00000000000000000000000000000000000000002445 163.0
HKD2_k127_7944212_14 Bacterial protein of unknown function (DUF883) - - - 0.00000000000000000000000003413 110.0
HKD2_k127_7944212_15 membrane - - - 0.0000000000000183 78.0
HKD2_k127_7944212_16 Protein of unknown function (DUF1800) - - - 0.000000002049 64.0
HKD2_k127_7944212_2 D-Ala-D-Ala carboxypeptidase 3 (S13) family K07259 - 3.4.16.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004636 441.0
HKD2_k127_7944212_3 Belongs to the OMP decarboxylase family. Type 2 subfamily K01591 - 4.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003708 394.0
HKD2_k127_7944212_4 Alpha/beta hydrolase family K01561 - 3.8.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006581 385.0
HKD2_k127_7944212_5 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006567 352.0
HKD2_k127_7944212_6 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 - 2.7.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007951 346.0
HKD2_k127_7944212_7 EamA-like transporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 338.0
HKD2_k127_7944212_8 COG0457 FOG TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001981 336.0
HKD2_k127_7944212_9 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.000000000000000000000000000000000000000000000000000000001824 203.0
HKD2_k127_7966302_0 synthetase K01895 - 6.2.1.1 3.024e-281 880.0
HKD2_k127_7966302_1 PFAM binding-protein-dependent transport systems inner membrane component K02011 - - 2.816e-228 722.0
HKD2_k127_7966302_10 TOBE domain K02010 - 3.6.3.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003662 428.0
HKD2_k127_7966302_11 e3 binding domain K00627 - 2.3.1.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004504 430.0
HKD2_k127_7966302_12 Protein of unknown function (DUF2855) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 401.0
HKD2_k127_7966302_13 transcriptional Regulator, LysR family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000441 347.0
HKD2_k127_7966302_14 Glycerol-3-phosphate dehydrogenase K00057 - 1.1.1.94 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006262 346.0
HKD2_k127_7966302_15 Pyridoxamine 5'-phosphate oxidase-related, FMN binding protein K07006 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003508 312.0
HKD2_k127_7966302_16 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000004811 304.0
HKD2_k127_7966302_17 haloacid dehalogenase-like hydrolase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003984 297.0
HKD2_k127_7966302_18 Membrane transport protein K07088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003566 254.0
HKD2_k127_7966302_19 SNARE associated Golgi protein K03975 - - 0.00000000000000000000000000000000000000000000000000000000000000001141 232.0
HKD2_k127_7966302_2 flavoprotein involved in K transport - - - 5.043e-204 644.0
HKD2_k127_7966302_20 PFAM bifunctional deaminase-reductase domain protein - - - 0.00000000000000000000000000000000000000000000000006904 198.0
HKD2_k127_7966302_21 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000000000000000000000000001956 172.0
HKD2_k127_7966302_23 Threonylcarbamoyl adenosine biosynthesis protein TsaE K06925 - - 0.00000000000000000000000000000000000001352 151.0
HKD2_k127_7966302_24 Protein of unknown function (DUF3175) - - - 0.0000000000000000000000000000000001477 136.0
HKD2_k127_7966302_25 Glutathione-dependent formaldehyde-activating enzyme family protein 4 - - - 0.0000000000000000000000000000000001836 137.0
HKD2_k127_7966302_26 FMN binding - - - 0.0000000000000000000000000000114 125.0
HKD2_k127_7966302_27 ParE toxin of type II toxin-antitoxin system, parDE - - - 0.0000000000000000000000000009785 116.0
HKD2_k127_7966302_28 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH K07746 - - 0.00000000000000000000004688 100.0
HKD2_k127_7966302_29 Phosphopantetheine attachment site - - - 0.000000000000000005619 94.0
HKD2_k127_7966302_3 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 - - 6.787e-197 629.0
HKD2_k127_7966302_30 Phosphopantetheine attachment site - - - 0.0000000000000151 81.0
HKD2_k127_7966302_31 WD-40 repeat - - - 0.000000000005613 78.0
HKD2_k127_7966302_32 Bacterial PH domain - - - 0.00000002527 58.0
HKD2_k127_7966302_34 extracellular matrix structural constituent - - - 0.0002535 50.0
HKD2_k127_7966302_4 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003332 518.0
HKD2_k127_7966302_5 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001787 501.0
HKD2_k127_7966302_6 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) K18979 - 1.17.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001603 480.0
HKD2_k127_7966302_7 LysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008859 468.0
HKD2_k127_7966302_8 Bacterial extracellular solute-binding protein K02012 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007595 457.0
HKD2_k127_7966302_9 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K21416 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001075 458.0
HKD2_k127_7976072_0 Belongs to the binding-protein-dependent transport system permease family K01995,K01998 - - 2.994e-271 865.0
HKD2_k127_7976072_1 amino acid K01999 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002224 571.0
HKD2_k127_7976072_2 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000243 462.0
HKD2_k127_7976072_3 Belongs to the thiolase family K00626,K07823 - 2.3.1.174,2.3.1.9 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000616 378.0
HKD2_k127_7976072_4 ATP-binding cassette (ABC) transporters are multidomain membrane proteins, responsible for the controlled efflux and influx of substances (allocrites) across cellular membranes. ATP-binding protein is for coupling the energy of ATP hydrolysis to conformational changes in the transmembrane domains K01996 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003122 365.0
HKD2_k127_7976072_5 Dienelactone hydrolase family K01061 - 3.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004002 312.0
HKD2_k127_7976072_6 Strictosidine synthase K10440 - - 0.0000000000000000000000000000000000109 138.0
HKD2_k127_7989406_0 Haemolysin-type calcium binding protein related domain - - - 0.0 1379.0
HKD2_k127_7989406_1 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 0.0 1140.0
HKD2_k127_7989406_10 Cupin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002238 430.0
HKD2_k127_7989406_11 Periplasmic domain of Sensor histidine kinase RisS K07638 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004775 416.0
HKD2_k127_7989406_12 response regulator K02483,K07659 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006257 401.0
HKD2_k127_7989406_13 Methionine biosynthesis protein MetW - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009994 417.0
HKD2_k127_7989406_14 Belongs to the GST superfamily K00799,K11209 - 2.5.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001099 385.0
HKD2_k127_7989406_15 Belongs to the pirin family K06911 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008299 388.0
HKD2_k127_7989406_16 Belongs to the pseudouridine synthase RsuA family K06178 - 5.4.99.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 362.0
HKD2_k127_7989406_17 Transcriptional regulator, LysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008834 338.0
HKD2_k127_7989406_18 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 - 5.4.99.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001777 332.0
HKD2_k127_7989406_19 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000887 281.0
HKD2_k127_7989406_2 GTP-binding protein K06207 - - 0.0 1009.0
HKD2_k127_7989406_20 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves K06024 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001823 274.0
HKD2_k127_7989406_21 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995,K08744 - 2.7.8.41,2.7.8.5 0.0000000000000000000000000000000000000000000000000000000000000000000002338 247.0
HKD2_k127_7989406_22 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.000000000000000000000000000000000000000000000000000000000000000000002987 264.0
HKD2_k127_7989406_23 acetyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000008828 231.0
HKD2_k127_7989406_24 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.00000000000000000000000000000000000000000000000000000000000029 232.0
HKD2_k127_7989406_25 Predicted integral membrane protein (DUF2189) - - - 0.0000000000000000000000000000000000000000000000000000000001165 213.0
HKD2_k127_7989406_26 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.00000000000000000000000000000000000000000000000000000001288 208.0
HKD2_k127_7989406_27 Required for maturation of 30S ribosomal subunits K09748 - - 0.000000000000000000000000000000000000000009391 168.0
HKD2_k127_7989406_28 - - - - 0.0000000000000000000000000000000000000003549 151.0
HKD2_k127_7989406_29 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000000000000000000004083 152.0
HKD2_k127_7989406_3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 1.038e-249 786.0
HKD2_k127_7989406_30 Protein of unknown function (DUF1178) - - - 0.000000000000000000000000000000000000001806 152.0
HKD2_k127_7989406_31 Activator of Hsp90 ATPase homolog 1-like protein - - - 0.000000000000000000000000000000000002935 144.0
HKD2_k127_7989406_32 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 0.000000000000000000000000000000001165 134.0
HKD2_k127_7989406_33 calcium- and calmodulin-responsive adenylate cyclase activity - - - 0.00000000000000000000007449 118.0
HKD2_k127_7989406_34 Protein of unknown function (DUF2788) - - - 0.000000000000000000001687 106.0
HKD2_k127_7989406_36 - - - - 0.0000002198 55.0
HKD2_k127_7989406_37 Protein of unknown function (DUF3106) - - - 0.0000008759 59.0
HKD2_k127_7989406_4 TIGRFAM type I secretion system ATPase K06147,K11004,K13409 - - 1.235e-240 765.0
HKD2_k127_7989406_5 Ammonium Transporter Family K03320,K06580 - - 3.602e-217 678.0
HKD2_k127_7989406_6 Participates in both transcription termination and antitermination K02600 - - 5.716e-215 678.0
HKD2_k127_7989406_7 PFAM Acyl-CoA dehydrogenase K00249 - 1.3.8.7 3.634e-211 669.0
HKD2_k127_7989406_8 HlyD membrane-fusion protein of T1SS K02022,K11003 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008248 457.0
HKD2_k127_7989406_9 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 424.0
HKD2_k127_799978_0 PFAM conserved - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005422 359.0
HKD2_k127_799978_1 Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) K01661,K07536 - 4.1.3.36 0.00000000000000000000000000000000000000000001819 177.0
HKD2_k127_799978_2 N-terminal half of MaoC dehydratase - - - 0.0000000000000001878 80.0
HKD2_k127_80247_0 short-chain dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001497 293.0
HKD2_k127_80247_1 Fad linked oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000006384 233.0
HKD2_k127_80247_2 Oxidoreductase - - - 0.00000000000000000000000001705 110.0
HKD2_k127_8044904_0 Oxidizes proline to glutamate for use as a carbon and nitrogen source K00249,K00294,K13821 - 1.2.1.88,1.3.8.7,1.5.5.2 0.0 1529.0
HKD2_k127_8044904_1 Efflux pump K03296,K18138,K18322 - - 0.0 1375.0
HKD2_k127_8044904_10 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346,K03502 GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 483.0
HKD2_k127_8044904_11 Belongs to the HpcH HpaI aldolase family K02510 - 4.1.2.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001848 442.0
HKD2_k127_8044904_12 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002473 445.0
HKD2_k127_8044904_13 Protein of unknown function (DUF692) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 432.0
HKD2_k127_8044904_14 TPR repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003478 454.0
HKD2_k127_8044904_15 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004008 421.0
HKD2_k127_8044904_16 Zinc metalloprotease (Elastase) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008555 413.0
HKD2_k127_8044904_17 Transcriptional regulatory protein, C terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006551 392.0
HKD2_k127_8044904_18 acetyl-CoA hydrolase K18288 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003678 369.0
HKD2_k127_8044904_19 Ion channel K10716 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002508 342.0
HKD2_k127_8044904_2 NADH flavin oxidoreductase NADH oxidase K00219 - 1.3.1.34 0.0 1053.0
HKD2_k127_8044904_20 Bacterial regulatory helix-turn-helix protein, lysR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005009 269.0
HKD2_k127_8044904_21 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000008127 236.0
HKD2_k127_8044904_22 T4-like virus tail tube protein gp19 - - - 0.00000000000000000000000000000000000000000000000000001131 193.0
HKD2_k127_8044904_23 DDE superfamily endonuclease - - - 0.0000000000000000000000000000000000000000000000002482 184.0
HKD2_k127_8044904_25 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000005992 188.0
HKD2_k127_8044904_26 helix_turn_helix, cAMP Regulatory protein K10914 - - 0.000000000000000000000000000000000000000000006966 172.0
HKD2_k127_8044904_27 - - - - 0.00000000000000000000000000000000000002581 146.0
HKD2_k127_8044904_28 - - - - 0.00000000000000000000000000000000001168 140.0
HKD2_k127_8044904_29 CHASE2 K01768 - 4.6.1.1 0.000000000000000000000000000000002785 148.0
HKD2_k127_8044904_3 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 1.399e-314 970.0
HKD2_k127_8044904_30 Amidohydrolase - - - 0.0000000000000000000000000000006968 123.0
HKD2_k127_8044904_31 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000007295 114.0
HKD2_k127_8044904_32 Acetyltransferase (GNAT) domain - - - 0.00000000000000000000001697 114.0
HKD2_k127_8044904_33 - - - - 0.0000000000000007239 85.0
HKD2_k127_8044904_34 Rhodanese-like domain - - - 0.00000000000004354 81.0
HKD2_k127_8044904_35 - - - - 0.0000000000005931 76.0
HKD2_k127_8044904_36 T4-like virus tail tube protein gp19 - - - 0.000000001817 64.0
HKD2_k127_8044904_37 - - - - 0.0000009266 59.0
HKD2_k127_8044904_4 mandelate racemase muconate lactonizing K01706 - 4.2.1.40 1.053e-248 773.0
HKD2_k127_8044904_5 Tartrate dehydrogenase K07246 - 1.1.1.83,1.1.1.93,4.1.1.73 5.166e-202 636.0
HKD2_k127_8044904_6 Thiolase, C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005454 579.0
HKD2_k127_8044904_7 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001455 574.0
HKD2_k127_8044904_8 Tripartite tricarboxylate transporter family receptor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002514 524.0
HKD2_k127_8044904_9 Benzoate membrane transport protein K05782 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000475 521.0
HKD2_k127_8047592_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 1.409e-236 738.0
HKD2_k127_8047592_1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003202 550.0
HKD2_k127_8047592_10 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002201 333.0
HKD2_k127_8047592_11 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit K02986 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002778 328.0
HKD2_k127_8047592_12 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002477 311.0
HKD2_k127_8047592_13 ABC-2 type transporter K09694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001369 295.0
HKD2_k127_8047592_14 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004243 278.0
HKD2_k127_8047592_15 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000009774 263.0
HKD2_k127_8047592_16 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs K02878 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001608 243.0
HKD2_k127_8047592_17 Necessary for normal cell division and for the maintenance of normal septation K03978 - - 0.000000000000000000000000000000000000000000000000000000000000000000001515 242.0
HKD2_k127_8047592_18 PFAM cytochrome c, class I - - - 0.000000000000000000000000000000000000000000000000000000000000000000002452 244.0
HKD2_k127_8047592_19 Binds to the 23S rRNA K02876 - - 0.0000000000000000000000000000000000000000000000000000000000000000002173 234.0
HKD2_k127_8047592_2 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides K00364 - 1.7.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003723 540.0
HKD2_k127_8047592_20 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.000000000000000000000000000000000000000000000000000000000000000006408 228.0
HKD2_k127_8047592_21 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000000000000000000000000000000000000000000000000002276 225.0
HKD2_k127_8047592_22 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.00000000000000000000000000000000000000000000000000000000000007374 218.0
HKD2_k127_8047592_23 Ribosomal protein L17 K02879 - - 0.000000000000000000000000000000000000000000000000000000000005871 212.0
HKD2_k127_8047592_24 Involved in the binding of tRNA to the ribosomes K02946 - - 0.000000000000000000000000000000000000000000000000000000006122 199.0
HKD2_k127_8047592_25 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.0000000000000000000000000000000000000000000000000000003518 196.0
HKD2_k127_8047592_26 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.000000000000000000000000000000000000000000000000000001083 194.0
HKD2_k127_8047592_27 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.00000000000000000000000000000000000000000000000000223 186.0
HKD2_k127_8047592_28 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000000000000000000000454 176.0
HKD2_k127_8047592_29 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.000000000000000000000000000000000000000000000003604 173.0
HKD2_k127_8047592_3 Belongs to the ALAD family K01698 GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002273 526.0
HKD2_k127_8047592_30 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 - - 0.0000000000000000000000000000000000000001762 151.0
HKD2_k127_8047592_31 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 - - 0.000000000000000000000000000000000000000909 149.0
HKD2_k127_8047592_32 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.0000000000000000000000000000000003491 135.0
HKD2_k127_8047592_33 heat shock protein K04762 - - 0.0000000000000000000000000000000005885 140.0
HKD2_k127_8047592_34 tolerance protein K03926 GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914 - 0.000000000000000000000000000000000966 144.0
HKD2_k127_8047592_35 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.000000000000000000000000000000002383 133.0
HKD2_k127_8047592_36 Ribosomal protein L30p/L7e K02907 - - 0.0000000000000000009851 94.0
HKD2_k127_8047592_37 Ribosomal L29 protein K02904 - - 0.00000000000000006382 83.0
HKD2_k127_8047592_38 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - 0.0000000000000001413 79.0
HKD2_k127_8047592_39 Belongs to the bacterial ribosomal protein bL36 family K02919 - - 0.000000000002951 72.0
HKD2_k127_8047592_4 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002012 466.0
HKD2_k127_8047592_40 protein conserved in bacteria K09914 - - 0.0003578 51.0
HKD2_k127_8047592_5 AAA domain, putative AbiEii toxin, Type IV TA system K01990,K09695 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009613 451.0
HKD2_k127_8047592_6 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007724 400.0
HKD2_k127_8047592_7 Forms part of the polypeptide exit tunnel K02926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002355 341.0
HKD2_k127_8047592_8 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001949 342.0
HKD2_k127_8047592_9 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004866 341.0
HKD2_k127_8063024_0 Vacuole effluxer Atg22 like K06902 - - 0.0000000000000000000000000000000000000000000000000000000000002047 233.0
HKD2_k127_8063024_1 Transcriptional regulator, Crp Fnr family K10914 - - 0.00000000000000000000000000001446 127.0
HKD2_k127_8063024_2 Type III secretion system lipoprotein chaperone (YscW) - - - 0.0000000000000000000000004706 110.0
HKD2_k127_8063024_3 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain K01652 - 2.2.1.6 0.0000000000000000009324 87.0
HKD2_k127_8109954_0 AAA domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003191 568.0
HKD2_k127_8109954_1 PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008899 564.0
HKD2_k127_8109954_10 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000005328 242.0
HKD2_k127_8109954_11 Putative DNA-binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000003104 248.0
HKD2_k127_8109954_12 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.00000000000000000000000000000000000000000000000000000000000000001303 231.0
HKD2_k127_8109954_13 DoxX K15977 - - 0.000000000000000000000000000000000000000000000000000000008236 205.0
HKD2_k127_8109954_14 Prokaryotic cytochrome b561 K12262 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000003115 199.0
HKD2_k127_8109954_15 Protein of unknown function (DUF1109) - - - 0.0000000000000000000000000000000000000000000000000001794 196.0
HKD2_k127_8109954_16 PFAM Tripartite ATP-independent periplasmic transporter, DctQ component - - - 0.000000000000000000000000000000000000008186 150.0
HKD2_k127_8109954_17 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000003233 153.0
HKD2_k127_8109954_18 Predicted integral membrane protein (DUF2282) - - - 0.000000000000000000000000002572 123.0
HKD2_k127_8109954_19 HNH endonuclease - - - 0.00000000000000001772 93.0
HKD2_k127_8109954_2 Transketolase, pyrimidine binding domain K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 540.0
HKD2_k127_8109954_3 Transketolase K00615 - 2.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008514 466.0
HKD2_k127_8109954_4 TIGRFAM TRAP dicarboxylate transporter, DctP subunit K21395 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003041 447.0
HKD2_k127_8109954_5 LysR family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006426 418.0
HKD2_k127_8109954_6 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001318 410.0
HKD2_k127_8109954_7 Saccharopine dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009199 415.0
HKD2_k127_8109954_8 D-alanine [D-alanyl carrier protein] ligase activity K00635 - 2.3.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009412 384.0
HKD2_k127_8109954_9 Belongs to the UPF0276 family K09930 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005249 372.0
HKD2_k127_813286_0 Aldehyde dehydrogenase family K00294,K13821 - 1.2.1.88,1.5.5.2 3.461e-222 700.0
HKD2_k127_813286_1 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - 0.00000000000000000000000000000000000000000000000000000000000000000000003194 251.0
HKD2_k127_813286_2 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - 0.00000000000000000000000000000000000006053 165.0
HKD2_k127_8179029_0 Trypsin-like peptidase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008452 354.0
HKD2_k127_8179029_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005644 337.0
HKD2_k127_8179029_2 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003938 252.0
HKD2_k127_8179029_3 Auxin binding protein - - - 0.000000000000000000000000000000000000003459 151.0
HKD2_k127_8179029_4 Cold shock K03704 - - 0.000000000000000000000005032 111.0
HKD2_k127_8184038_0 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007902 620.0
HKD2_k127_8184038_1 Sodium Bile acid symporter family K03325 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009894 537.0
HKD2_k127_8184038_10 glyoxalase bleomycin resistance protein dioxygenase - - - 0.000000000000000000000000000000000000000000000000002031 192.0
HKD2_k127_8184038_11 Protein of unknown function (DUF1810) - - - 0.00000000000000000000000000000000000000000000000001037 185.0
HKD2_k127_8184038_12 helix_turn_helix, Arsenical Resistance Operon Repressor K03892 - - 0.0000000000000000000000000000000001001 136.0
HKD2_k127_8184038_14 COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs K07303 - 1.3.99.16 0.00000000000000000000000000003695 119.0
HKD2_k127_8184038_15 redox-active disulfide protein 2 - - - 0.000000000000000000000000000566 114.0
HKD2_k127_8184038_16 Acetyltransferase (GNAT) domain K00619 - 2.3.1.1 0.00000000000000000000002418 104.0
HKD2_k127_8184038_2 Aminotransferase K09758 - 4.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003853 536.0
HKD2_k127_8184038_3 Predicted permease K07089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 489.0
HKD2_k127_8184038_4 Enoyl-CoA hydratase/isomerase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003314 350.0
HKD2_k127_8184038_5 Reversible hydration of carbon dioxide K01673 - 4.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001197 310.0
HKD2_k127_8184038_6 COG1247 Sortase and related acyltransferases - - - 0.0000000000000000000000000000000000000000000000000000000000000000002024 235.0
HKD2_k127_8184038_7 Belongs to the low molecular weight phosphotyrosine protein phosphatase family K03741 - 1.20.4.1 0.000000000000000000000000000000000000000000000000000000000000000002358 235.0
HKD2_k127_8184038_8 Methyltransferase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000002651 231.0
HKD2_k127_8184038_9 COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs K07302 - 1.3.99.16 0.000000000000000000000000000000000000000000000000000000000000001366 222.0
HKD2_k127_819860_0 Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine K00641 - 2.3.1.31 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003545 608.0
HKD2_k127_819860_1 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K08483 - 2.7.3.9 0.000000000000000000000000000000000000000000000000000000000561 206.0
HKD2_k127_819860_2 Las17-binding protein actin regulator - - - 0.00000000000000000000001419 108.0
HKD2_k127_8206691_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 3.927e-313 972.0
HKD2_k127_8242954_0 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) K01969 - 6.4.1.4 6.535e-288 890.0
HKD2_k127_8242954_1 PFAM acyl-CoA dehydrogenase domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009958 599.0
HKD2_k127_8242954_10 Acetyl propionyl-CoA carboxylase, alpha subunit K01968 - 6.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000005283 224.0
HKD2_k127_8242954_11 Domain of unknown function (DUF4126) - - - 0.000000000000000000000000000000000000000000000000000000000002177 216.0
HKD2_k127_8242954_12 Endoribonuclease L-PSP - - - 0.0000000000000000000000000000000000000000000000000000001609 196.0
HKD2_k127_8242954_13 Lysine exporter protein LysE K11250 - - 0.000000000000000000000000000000000000000000000000001186 190.0
HKD2_k127_8242954_14 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000000009273 184.0
HKD2_k127_8242954_2 Acyl-CoA dehydrogenase, C-terminal domain K00249 - 1.3.8.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008423 520.0
HKD2_k127_8242954_3 Thiolase, C-terminal domain K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001954 491.0
HKD2_k127_8242954_4 Sugar (and other) transporter K08151 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004325 462.0
HKD2_k127_8242954_5 enoyl-CoA hydratase K13766,K15312 - 4.2.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005989 336.0
HKD2_k127_8242954_6 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000003325 245.0
HKD2_k127_8242954_7 short-chain dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000000000000000005632 231.0
HKD2_k127_8242954_8 DSBA-like thioredoxin domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000886 227.0
HKD2_k127_8242954_9 Methyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000001153 232.0
HKD2_k127_8266397_0 NAD(P) transhydrogenase, alpha subunit K00324 - 1.6.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000173 527.0
HKD2_k127_8266397_1 Belongs to the Nudix hydrolase family. NudJ subfamily - - - 0.000000000000000000000000000000000000000000000000000000003802 207.0
HKD2_k127_8278286_0 COG0823 Periplasmic component of the Tol biopolymer transport system - - - 0.0 1409.0
HKD2_k127_8278286_1 Tetratricopeptide repeat - - - 0.0 1143.0
HKD2_k127_8278286_10 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003539 261.0
HKD2_k127_8278286_11 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001271 261.0
HKD2_k127_8278286_12 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002233 252.0
HKD2_k127_8278286_13 Glutathione peroxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000004235 250.0
HKD2_k127_8278286_14 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005034 263.0
HKD2_k127_8278286_16 - - - - 0.000000000000000000000000000000000000000000000000000000000001774 216.0
HKD2_k127_8278286_17 Biopolymer transport protein ExbD/TolR - - - 0.000000000000000000000000000000000000000000000000000001759 197.0
HKD2_k127_8278286_18 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000006729 194.0
HKD2_k127_8278286_19 Biopolymer transport protein ExbD/TolR - - - 0.000000000000000000000000000000000000000000000000001538 187.0
HKD2_k127_8278286_2 PKD domain containing protein K01337,K20276,K21449 - 3.4.21.50 0.0 1107.0
HKD2_k127_8278286_20 Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - 0.000000000000000000000000000000000647 136.0
HKD2_k127_8278286_21 Autotransporter beta-domain - - - 0.000000000000000000000000000000009643 150.0
HKD2_k127_8278286_22 - - - - 0.0000000000000000000000000000005655 127.0
HKD2_k127_8278286_23 response regulator - - - 0.0005817 44.0
HKD2_k127_8278286_3 Tetratricopeptide repeat - - - 8.063e-195 629.0
HKD2_k127_8278286_4 Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein K03734 - 2.7.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001555 435.0
HKD2_k127_8278286_5 Protein of unknown function (DUF3570) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001529 420.0
HKD2_k127_8278286_6 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000174 364.0
HKD2_k127_8278286_7 Bacterial SH3 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000268 330.0
HKD2_k127_8278286_8 MotA/TolQ/ExbB proton channel family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002159 316.0
HKD2_k127_8278286_9 Thiopurine S-methyltransferase (TPMT) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004485 309.0
HKD2_k127_8301976_0 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 334.0
HKD2_k127_8301976_1 Alpha beta hydrolase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000211 273.0
HKD2_k127_8301976_2 Protein of unknown function (DUF3014) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001221 257.0
HKD2_k127_8313787_0 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 5.125e-223 724.0
HKD2_k127_8313787_1 Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K04744 - - 2.325e-214 690.0
HKD2_k127_8313787_10 Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione K01759 - 4.4.1.5 0.00000000000000000000000000000000000000000000000000000000002885 209.0
HKD2_k127_8313787_11 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) K00992 - 2.7.7.99 0.000000000005849 67.0
HKD2_k127_8313787_2 glycyl-tRNA synthetase alpha subunit K01878 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004015 538.0
HKD2_k127_8313787_3 Ferrous iron transport protein B K04759 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 483.0
HKD2_k127_8313787_4 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation K03771 - 5.2.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000584 466.0
HKD2_k127_8313787_5 Aminoglycoside phosphotransferase K07102 - 2.7.1.221 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009024 448.0
HKD2_k127_8313787_6 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) K00097 - 1.1.1.262 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004531 364.0
HKD2_k127_8313787_7 Acyltransferase K00655 - 2.3.1.51 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003967 314.0
HKD2_k127_8313787_8 Ribosomal RNA adenine dimethylases K02528 - 2.1.1.182 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000009197 300.0
HKD2_k127_8313787_9 Metal-dependent hydrolase K07043 - - 0.000000000000000000000000000000000000000000000000000000000000000000000007517 253.0
HKD2_k127_8342396_0 penicillin-binding protein 1A K05366 - 2.4.1.129,3.4.16.4 9.102e-294 923.0
HKD2_k127_8342396_1 Secretin and TonB N terminus short domain K02666 - - 1.308e-242 771.0
HKD2_k127_8342396_10 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) K01735,K13829 - 2.7.1.71,4.2.3.4 0.00000000000000000000000000000000000000000000000708 178.0
HKD2_k127_8342396_11 Belongs to the frataxin family K06202 - - 0.00000000000000000000000000000002361 129.0
HKD2_k127_8342396_2 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008043 552.0
HKD2_k127_8342396_3 Type IV pilus assembly protein PilM; K02662 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006357 473.0
HKD2_k127_8342396_4 Pilus assembly protein, PilO K02664 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001945 256.0
HKD2_k127_8342396_5 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain K17247 - - 0.00000000000000000000000000000000000000000000000000000000000000001889 236.0
HKD2_k127_8342396_6 Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide K07147 - - 0.00000000000000000000000000000000000000000000000000005742 188.0
HKD2_k127_8342396_7 Fimbrial assembly protein (PilN) K02663 - - 0.0000000000000000000000000000000000000000000000000001254 198.0
HKD2_k127_8342396_8 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000000000000000000000000000001499 193.0
HKD2_k127_8342396_9 Pilus assembly protein, PilP K02665 - - 0.0000000000000000000000000000000000000000000000000007847 195.0
HKD2_k127_8391218_0 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001969 511.0
HKD2_k127_8391218_1 Flavin containing amine oxidoreductase K06954 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002766 486.0
HKD2_k127_8391218_10 Belongs to the glutathione peroxidase family K00432 - 1.11.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000001488 249.0
HKD2_k127_8391218_11 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000004703 237.0
HKD2_k127_8391218_12 Protein of unknown function (DUF3833) - - - 0.00000000000000000000000000000000000000000000000000000009087 199.0
HKD2_k127_8391218_13 SnoaL-like domain K01822 - 5.3.3.1 0.000000000000000000000000000000000000000000000000006588 184.0
HKD2_k127_8391218_14 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000005182 197.0
HKD2_k127_8391218_15 Chalcone isomerase-like - - - 0.00000000000000000000000000000000000000005937 163.0
HKD2_k127_8391218_2 cyclopropane-fatty-acyl-phospholipid synthase K00574 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008168,GO:0008610,GO:0008757,GO:0009058,GO:0009059,GO:0009273,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0032787,GO:0034645,GO:0042546,GO:0043170,GO:0043436,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070589,GO:0071554,GO:0071704,GO:0071766,GO:0071767,GO:0071768,GO:0071840,GO:0071944,GO:0072330,GO:1901576 2.1.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004499 483.0
HKD2_k127_8391218_3 MFS/sugar transport protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000849 372.0
HKD2_k127_8391218_4 PFAM L-asparaginase II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006076 361.0
HKD2_k127_8391218_5 Protein of unknown function (DUF1365) K09701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001559 334.0
HKD2_k127_8391218_6 Converts GTP to 7,8-dihydroneopterin triphosphate K01495,K09007 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005142 332.0
HKD2_k127_8391218_7 PFAM major facilitator superfamily MFS_1 K19577 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002728 335.0
HKD2_k127_8391218_8 Enoyl-(Acyl carrier protein) reductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 324.0
HKD2_k127_8391218_9 KR domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002384 299.0
HKD2_k127_8477149_0 PFAM cell divisionFtsK SpoIIIE K03466 - - 5.019e-216 686.0
HKD2_k127_8477149_1 LytTr DNA-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003052 271.0
HKD2_k127_8477149_2 Histidine kinase - - - 0.00000000000000000000000000000000000000000000000000587 197.0
HKD2_k127_8477149_3 Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family K00384 - 1.8.1.9 0.0000000000000000000004673 96.0
HKD2_k127_8477149_4 Histidine kinase - - - 0.000000000000000000001146 108.0
HKD2_k127_85161_0 Biotin carboxylase C-terminal domain K01965 - 6.4.1.3 8.79e-309 958.0
HKD2_k127_85161_1 Belongs to the IlvD Edd family K01687 - 4.2.1.9 1.119e-296 917.0
HKD2_k127_85161_10 Belongs to the binding-protein-dependent transport system permease family K01997 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004814 450.0
HKD2_k127_85161_11 amino acid K01999 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002228 452.0
HKD2_k127_85161_12 ArgK protein K07588 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007746 398.0
HKD2_k127_85161_13 PFAM ABC transporter related K01995 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 394.0
HKD2_k127_85161_14 abc transporter K01996 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003642 371.0
HKD2_k127_85161_15 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde K00145 - 1.2.1.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004549 380.0
HKD2_k127_85161_16 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003157 360.0
HKD2_k127_85161_17 Transglutaminase/protease-like homologues - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002177 319.0
HKD2_k127_85161_18 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.000000000000000000000000000000000000000000000000000000000000000000000002569 248.0
HKD2_k127_85161_19 Tripartite ATP-independent periplasmic transporter dctq component - - - 0.0000000000000000000000000000000000000000000000000001211 197.0
HKD2_k127_85161_2 PFAM carboxyl transferase K01966 - 2.1.3.15,6.4.1.3 1.285e-292 904.0
HKD2_k127_85161_20 RmlD substrate binding domain - - - 0.0000000000000000000000000000000000000000000000002539 179.0
HKD2_k127_85161_21 Transcriptional regulator K07734 - - 0.000000000000000000000000000000000000000000005756 178.0
HKD2_k127_85161_22 RmlD substrate binding domain - - - 0.000000000000000000000000000000000000000002713 162.0
HKD2_k127_85161_23 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000007349 160.0
HKD2_k127_85161_24 Cytochrome c K08738 - - 0.000000000000000000000000000000000001439 141.0
HKD2_k127_85161_25 Bacterial extracellular solute-binding protein, family 7 - - - 0.000000000000008662 78.0
HKD2_k127_85161_26 - - - - 0.000000000004961 69.0
HKD2_k127_85161_3 Methylmalonyl-CoA mutase K01847 - 5.4.99.2 1.617e-241 752.0
HKD2_k127_85161_4 TRAP C4-dicarboxylate transport system permease DctM subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002388 557.0
HKD2_k127_85161_5 Oxidoreductase FAD-binding domain K00523,K18248 - 1.17.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002262 483.0
HKD2_k127_85161_6 Belongs to the binding-protein-dependent transport system permease family K01998 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001034 476.0
HKD2_k127_85161_7 PFAM Transketolase central region K00162,K21417 - 1.2.4.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004482 455.0
HKD2_k127_85161_8 D-amino acid K00285 - 1.4.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001709 460.0
HKD2_k127_85161_9 Dehydrogenase E1 component K00161,K21416 - 1.2.4.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 458.0
HKD2_k127_8599536_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 0.0 1339.0
HKD2_k127_8599536_1 Two component regulator propeller - - - 1.444e-272 859.0
HKD2_k127_8599536_10 ATPase family associated with various cellular activities (AAA) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008427 618.0
HKD2_k127_8599536_11 Phage tail sheath C-terminal domain K06907 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001053 612.0
HKD2_k127_8599536_12 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007802 547.0
HKD2_k127_8599536_13 AMP-binding enzyme C-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008295 524.0
HKD2_k127_8599536_14 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002186 500.0
HKD2_k127_8599536_15 2-nitropropane dioxygenase K00459 - 1.13.12.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002993 488.0
HKD2_k127_8599536_16 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis K00560 - 2.1.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007311 475.0
HKD2_k127_8599536_17 - K06905 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008433 477.0
HKD2_k127_8599536_18 Transglycosylase SLT domain K08307 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001137 451.0
HKD2_k127_8599536_19 Protein of unknown function (DUF4255) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001066 434.0
HKD2_k127_8599536_2 ABC transporter transmembrane region K06147 - - 2.434e-270 843.0
HKD2_k127_8599536_20 Enoyl- acyl-carrier-protein reductase NADH K00208 - 1.3.1.10,1.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001406 419.0
HKD2_k127_8599536_21 Sulfatase-modifying factor enzyme 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004327 420.0
HKD2_k127_8599536_22 Lipocalin-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004895 383.0
HKD2_k127_8599536_23 cellulose binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 378.0
HKD2_k127_8599536_24 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid K01069 - 3.1.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006453 354.0
HKD2_k127_8599536_25 Nucleotidyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007013 349.0
HKD2_k127_8599536_26 EamA-like transporter family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003283 340.0
HKD2_k127_8599536_27 AAA-type ATPase, and DNA-binding domains - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002564 338.0
HKD2_k127_8599536_28 T4-like virus tail tube protein gp19 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003611 322.0
HKD2_k127_8599536_29 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001664 337.0
HKD2_k127_8599536_3 AMP-binding enzyme - - - 1.01e-269 842.0
HKD2_k127_8599536_30 phage tail tape measure protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001217 327.0
HKD2_k127_8599536_31 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001448 317.0
HKD2_k127_8599536_32 NADPH-dependent FMN reductase K19784 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000573 309.0
HKD2_k127_8599536_33 Histidine-specific methyltransferase, SAM-dependent - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000727 328.0
HKD2_k127_8599536_34 PFAM Lysine exporter protein (LYSE YGGA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001457 302.0
HKD2_k127_8599536_35 Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid K18235 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001079 301.0
HKD2_k127_8599536_36 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease K02342 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000006392 300.0
HKD2_k127_8599536_37 Glutathione S-transferase K00799 - 2.5.1.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002941 293.0
HKD2_k127_8599536_38 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005916 282.0
HKD2_k127_8599536_39 CDGSH-type zinc finger. Function unknown. - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000499 265.0
HKD2_k127_8599536_4 Belongs to the TPP enzyme family K01652 - 2.2.1.6 6.545e-268 835.0
HKD2_k127_8599536_40 domain, Protein K01179 - 3.2.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000001545 283.0
HKD2_k127_8599536_41 PFAM ABC transporter related K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001479 260.0
HKD2_k127_8599536_42 PFAM Phage-related baseplate assembly protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000006566 245.0
HKD2_k127_8599536_43 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids K03469 - 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000007617 236.0
HKD2_k127_8599536_44 - - - - 0.00000000000000000000000000000000000000000000000000000000000000004459 228.0
HKD2_k127_8599536_45 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000000005473 215.0
HKD2_k127_8599536_46 Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis K00287 - 1.5.1.3 0.000000000000000000000000000000000000000000000000000004254 199.0
HKD2_k127_8599536_47 - - - - 0.00000000000000000000000000000000000000000000001631 179.0
HKD2_k127_8599536_48 Gene 25-like lysozyme K06903 - - 0.0000000000000000000000000000000000000000000001318 170.0
HKD2_k127_8599536_49 Scavenger mRNA decapping enzyme C-term binding - - - 0.0000000000000000000000000000000000000000004249 162.0
HKD2_k127_8599536_5 COG0474 Cation transport ATPase K01531 - 3.6.3.2 7.679e-262 831.0
HKD2_k127_8599536_50 acetyltransferase - - - 0.000000000000000000000000000000000000002059 154.0
HKD2_k127_8599536_51 - - - - 0.00000000000000000000000000000000000003811 145.0
HKD2_k127_8599536_52 - - - - 0.0000000000000000000000000000000000001295 145.0
HKD2_k127_8599536_53 MAPEG family - - - 0.000000000000000000000000000000000004098 141.0
HKD2_k127_8599536_54 LysM domain - - - 0.000000000000000000000000000000555 124.0
HKD2_k127_8599536_55 enzyme binding - - - 0.00000000000000000000000000002985 124.0
HKD2_k127_8599536_56 YbaK prolyl-tRNA synthetase K19055 - - 0.0000000000000000000000001184 112.0
HKD2_k127_8599536_57 Methyltransferase domain - - - 0.0000000000000000000000007538 115.0
HKD2_k127_8599536_58 Domain of unknown function (DUF4157) - - - 0.0000000000000000000018 106.0
HKD2_k127_8599536_6 homolog of phage Mu protein gp47 - - - 1.859e-251 801.0
HKD2_k127_8599536_61 - - - - 0.0000001239 57.0
HKD2_k127_8599536_7 FtsX-like permease family K02004 - - 3.428e-229 753.0
HKD2_k127_8599536_8 protein, phage tail-like region - - - 2.902e-210 693.0
HKD2_k127_8599536_9 Pro-kumamolisin, activation domain K08677 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003269 610.0
HKD2_k127_8783681_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 1.972e-290 900.0
HKD2_k127_8783681_1 Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex K04039 - 1.3.7.7 1.364e-250 783.0
HKD2_k127_8783681_10 PFAM 2-vinyl bacteriochlorophyllide hydratase K11336 - 4.2.1.165 0.00000000000000000000000000000000000000000000000000000000000000002258 228.0
HKD2_k127_8783681_11 TspO/MBR family K05770 - - 0.00000000000000000000000000000000000000000000000000000000003425 211.0
HKD2_k127_8783681_12 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.000000000000000000000000000000000000000000000583 168.0
HKD2_k127_8783681_13 B12 binding domain - - - 0.00000000000000000000000000000000000000002941 165.0
HKD2_k127_8783681_14 - - - - 0.000000000000004884 78.0
HKD2_k127_8783681_2 Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein (BchN-BchB) is the catalytic component of the complex K04038 - 1.3.7.7 2.723e-202 644.0
HKD2_k127_8783681_3 TIGRFAM geranylgeranyl reductase K10960 - 1.3.1.111,1.3.1.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001655 549.0
HKD2_k127_8783681_4 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 534.0
HKD2_k127_8783681_5 Disulphide bond corrector protein DsbC K04084,K08344 - 1.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009018 532.0
HKD2_k127_8783681_6 Light harvesting pigment Major Facilitator Family (MFS) transporter K08226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005635 488.0
HKD2_k127_8783681_7 Aminotransferase class-III K01845 - 5.4.3.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005784 423.0
HKD2_k127_8783681_8 UbiA prenyltransferase family K04040 - 2.5.1.133,2.5.1.62 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005229 421.0
HKD2_k127_8783681_9 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000000000000000000000000000001807 233.0
HKD2_k127_8994488_0 fad dependent oxidoreductase K07137 - - 7.721e-216 676.0
HKD2_k127_8994488_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002025 415.0
HKD2_k127_9014205_0 acyl-CoA dehydrogenase K00248 - 1.3.8.1 4.419e-281 875.0
HKD2_k127_9014205_1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain K07516 - 1.1.1.35 2.162e-270 851.0
HKD2_k127_9014205_2 PFAM Alcohol dehydrogenase zinc-binding domain protein K07119 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000474 483.0
HKD2_k127_9014205_3 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate K00046 - 1.1.1.69 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000336 397.0
HKD2_k127_9014205_4 PFAM ABC transporter related K01996 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002183 333.0
HKD2_k127_9014205_5 Stress responsive A/B Barrel Domain - - - 0.0000000000000000000000000000000000000000002126 160.0
HKD2_k127_9014205_6 Branched-chain amino acid ATP-binding cassette transporter K01995 - - 0.000000000000007136 74.0
HKD2_k127_9056330_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002169 603.0
HKD2_k127_9056330_1 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002519 411.0
HKD2_k127_9056330_10 VacJ family lipoprotein K04754 - - 0.0000000000000000000000000000000000000000000000000000000000004824 228.0
HKD2_k127_9056330_11 glutamate synthase K00266 - 1.4.1.13,1.4.1.14 0.0000000000000000000000000000000000000000004251 158.0
HKD2_k127_9056330_12 COG2010 Cytochrome c, mono- and diheme variants - - - 0.00000000000000000000000000000000002495 139.0
HKD2_k127_9056330_13 Acyl-ACP thioesterase - - - 0.0000000000000000000000000000000001087 138.0
HKD2_k127_9056330_14 COG2010 Cytochrome c, mono- and diheme variants - - - 0.0000000000000000000000000000003399 127.0
HKD2_k127_9056330_15 Belongs to the BolA IbaG family - - - 0.000000000000000000000000001936 124.0
HKD2_k127_9056330_16 STAS domain K07122 - - 0.00000000005845 66.0
HKD2_k127_9056330_17 Outer membrane lipoprotein K06077 - - 0.000000002987 63.0
HKD2_k127_9056330_2 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 400.0
HKD2_k127_9056330_3 Transport permease protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003035 378.0
HKD2_k127_9056330_4 Permease MlaE K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 376.0
HKD2_k127_9056330_5 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity K00765 - 2.4.2.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002649 327.0
HKD2_k127_9056330_6 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 - 1.1.1.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001155 309.0
HKD2_k127_9056330_7 PFAM extracellular solute-binding protein family 3 K02030,K09969,K10001 - - 0.000000000000000000000000000000000000000000000000000000000000000000008691 243.0
HKD2_k127_9056330_8 MlaC protein K07323 - - 0.000000000000000000000000000000000000000000000000000000000000000006188 231.0
HKD2_k127_9056330_9 MlaD protein K02067 - - 0.00000000000000000000000000000000000000000000000000000000000001195 226.0
HKD2_k127_9098729_0 carboxymethylenebutenolidase activity K01061,K22249 - 3.1.1.45,3.1.1.76 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 360.0
HKD2_k127_9098729_1 TonB C terminal - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006304 372.0
HKD2_k127_9098729_2 SCP-2 sterol transfer family - - - 0.0000000000000000000000000000000000000000000000000000003694 203.0
HKD2_k127_9098729_3 Protein of unknown function, DUF599 - - - 0.0000000000000000000000000000000000000000000000000044 189.0
HKD2_k127_9098729_4 part of a sulfur-relay system K11179 - - 0.0000000000000000000000000000000000000001083 156.0
HKD2_k127_9098729_5 Pilin (bacterial filament) K02650 - - 0.000000000000000000000000000009792 123.0
HKD2_k127_9100503_0 phenylacetic acid degradation protein paaN - - - 1.499e-264 824.0
HKD2_k127_9100503_1 FAD binding domain K05712 - 1.14.13.127 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005542 564.0
HKD2_k127_9100503_2 Enoyl-CoA hydratase/isomerase K15866 - 5.3.3.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004246 351.0
HKD2_k127_9100503_3 Bacterial transferase hexapeptide (six repeats) K02617,K08279 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001035 292.0
HKD2_k127_9100503_4 HIT domain - - - 0.00000000000000000000000000000000000000000000005759 174.0
HKD2_k127_9100503_5 Uncharacterized ACR, COG1993 K09137 - - 0.000000000000000000000000000000000000007635 154.0
HKD2_k127_9100503_6 Protein of unknown function (DUF2783) - - - 0.0000000000000000003013 91.0
HKD2_k127_9105402_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001055 378.0
HKD2_k127_9105402_1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - 0.000000000000000000000000000000000000000000000000000000000000000000001677 245.0
HKD2_k127_9105402_2 4-carboxymuconolactone decarboxylase K01607 - 4.1.1.44 0.000000000000000000000000000000000000000000000000000000000000000000008529 237.0
HKD2_k127_9105402_3 ABC-type branched-chain amino acid transport systems, periplasmic component K01999 - - 0.0000000000000000000007058 97.0
HKD2_k127_9108186_0 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005405 600.0
HKD2_k127_9108186_1 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001386 412.0
HKD2_k127_9113322_0 PFAM extracellular solute-binding protein family 5 K12368 - - 3.123e-295 917.0
HKD2_k127_9113322_1 PFAM extracellular solute-binding protein, family 5 K02035 - - 3.278e-238 746.0
HKD2_k127_9113322_10 Belongs to the NiCoT transporter (TC 2.A.52) family K07241 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001062 344.0
HKD2_k127_9113322_11 Protein of unknown function (DUF3047) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002696 254.0
HKD2_k127_9113322_12 Transcriptional regulator K07722 - - 0.000000000000000000000000000000000000000000000000000000000002199 213.0
HKD2_k127_9113322_13 NAD(P)H-binding - - - 0.0000000000000000000000000000000000000002874 161.0
HKD2_k127_9113322_14 Belongs to the ABC transporter superfamily K02031 - - 0.00000000000000000000000000000000001417 151.0
HKD2_k127_9113322_15 - - - - 0.00000000000000000000000000154 111.0
HKD2_k127_9113322_2 Penicillin amidase K01434 - 3.5.1.11 2.755e-226 726.0
HKD2_k127_9113322_3 PFAM binding-protein-dependent transport systems inner membrane component K02033,K12369 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006747 557.0
HKD2_k127_9113322_4 Metal-dependent amidase aminoacylase carboxypeptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009114 545.0
HKD2_k127_9113322_5 ABC-type dipeptide oligopeptide nickel transport systems, permease components K02033 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001823 492.0
HKD2_k127_9113322_6 Belongs to the ABC transporter superfamily K12371 GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002421 483.0
HKD2_k127_9113322_7 Belongs to the ABC transporter superfamily K12372 GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0006810,GO:0008144,GO:0008150,GO:0009314,GO:0009628,GO:0015232,GO:0015886,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001372 484.0
HKD2_k127_9113322_8 N-terminal TM domain of oligopeptide transport permease C K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002199 452.0
HKD2_k127_9113322_9 PFAM binding-protein-dependent transport systems inner membrane component K02034,K12370 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002329 450.0
HKD2_k127_9136325_0 5'-nucleotidase, C-terminal domain K11751,K17224 - 3.1.3.5,3.6.1.45 1.205e-289 908.0
HKD2_k127_9136325_1 Thiosulfate-oxidizing multienzyme system protein SoxA K17222 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007582 352.0
HKD2_k127_9136325_10 Belongs to the sulfur carrier protein TusA family K04085 - - 0.000000000000000000000000009338 111.0
HKD2_k127_9136325_11 COG0526, thiol-disulfide isomerase and thioredoxins - - - 0.00000000000000000007748 95.0
HKD2_k127_9136325_2 DsrE/DsrF/DrsH-like family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008007 252.0
HKD2_k127_9136325_3 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003148 261.0
HKD2_k127_9136325_4 Cytochrome c K17223 - - 0.00000000000000000000000000000000000000000000000000000000000002228 221.0
HKD2_k127_9136325_5 Sulfur oxidation protein SoxY K17226 - - 0.00000000000000000000000000000000000000000000000000000003205 201.0
HKD2_k127_9136325_6 DsrE/DsrF-like family K09004 - - 0.0000000000000000000000000000000000000000002122 164.0
HKD2_k127_9136325_7 oxidation protein K17227 - - 0.0000000000000000000000000000000000000001261 153.0
HKD2_k127_9136325_8 Thioredoxin-like - - - 0.00000000000000000000000000000000000007005 148.0
HKD2_k127_9136325_9 Peptidase S24-like - - - 0.0000000000000000000000000000005655 127.0
HKD2_k127_9148770_0 Ion channel K10716 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003944 284.0
HKD2_k127_9148770_1 Thioesterase superfamily K19222 - 3.1.2.28 0.000000000000000000000000000000000000000002623 166.0
HKD2_k127_9148770_2 PFAM binding-protein-dependent transport systems inner membrane component K02050,K15552 - - 0.0000000000000000000000000001069 115.0
HKD2_k127_9188566_0 Peptidase M61 - - - 2.478e-221 705.0
HKD2_k127_9188566_1 Belongs to the TrpC family K01609 - 4.1.1.48 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 340.0
HKD2_k127_9188566_2 Protein of unknown function, DUF599 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001766 325.0
HKD2_k127_9188566_3 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine K03648 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000000000000004233 256.0
HKD2_k127_9188566_4 MobA-like NTP transferase domain K07141 - 2.7.7.76 0.00000000000000001632 83.0
HKD2_k127_9188566_5 Acetyltransferase K03828 - - 0.0002151 49.0
HKD2_k127_9191810_0 Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates K00179 - 1.2.7.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003885 512.0
HKD2_k127_9191810_1 Pyruvate ferredoxin/flavodoxin oxidoreductase K00179,K00180 - 1.2.7.8 0.0000000000000000000000000000000000000000000005415 185.0
HKD2_k127_9238550_0 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 1.061e-207 677.0
HKD2_k127_9238550_1 PFAM methyltransferase - - - 0.00000000000000000000000000000000000002465 146.0
HKD2_k127_9260891_0 Secretin and TonB N terminus short domain K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002189 434.0
HKD2_k127_9260891_1 Prokaryotic N-terminal methylation motif K02456 - - 0.00000000000000000000000000000000000000000000000000001475 203.0
HKD2_k127_9260891_2 Type II secretory pathway pseudopilin - - - 0.0000000000000000000000000000000000000001278 155.0
HKD2_k127_9260891_3 Type II secretion system protein G K02456 - - 0.000000000000000000000000000000000000001224 160.0
HKD2_k127_9285317_0 Major Facilitator Superfamily K08177 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007304 601.0
HKD2_k127_9285317_1 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II K18661 - - 0.0000000000000000000000000000000000004438 146.0
HKD2_k127_9288560_0 Oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000199 445.0
HKD2_k127_9288560_1 Bacterial extracellular solute-binding protein K02012 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000163 430.0
HKD2_k127_9288560_2 Serine aminopeptidase, S33 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001284 278.0
HKD2_k127_9288560_3 Iron-storage protein K03594 - 1.16.3.1 0.0000000000000000000000000000000000000000000000000000000000000000001517 233.0
HKD2_k127_9288560_4 COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.00000000000000000000000000000000000000000000000000000000004885 221.0
HKD2_k127_9288560_5 PFAM NLP P60 protein - - - 0.0000000000000000000000000000000000000004028 157.0
HKD2_k127_9288560_6 radical SAM domain protein - - - 0.000000000000000001014 94.0
HKD2_k127_9288560_7 2Fe-2S -binding domain protein K02192 - - 0.000000002547 65.0
HKD2_k127_9288560_8 radical SAM domain protein - - - 0.000000009193 62.0
HKD2_k127_9427978_0 Transcriptional regulator K03603,K05799 - - 2.088e-250 804.0
HKD2_k127_9427978_1 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine K06168 - 2.8.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008418 494.0
HKD2_k127_9427978_2 PFAM PhoH family protein K06217 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003177 435.0
HKD2_k127_9427978_3 Uncharacterized protein family UPF0054 K07042 - - 0.00000008262 57.0
HKD2_k127_9517757_0 Patatin-like phospholipase K07001 - - 3.882e-245 783.0
HKD2_k127_9517757_1 exo-alpha-(2->6)-sialidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009881 345.0
HKD2_k127_9517757_2 sister chromatid segregation - - - 0.00000000000000000000000000000000000000000000000000000000000000000008427 241.0
HKD2_k127_9517757_3 Major Facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000001769 175.0
HKD2_k127_9517757_4 cellulase activity - - - 0.000000001145 69.0
HKD2_k127_9562081_0 Beta-ketoacyl synthase, N-terminal domain K00647 - 2.3.1.41 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 473.0
HKD2_k127_9562081_1 PFAM Glycosyl transferase, family 2 K00786 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 357.0
HKD2_k127_9562081_2 ubiE/COQ5 methyltransferase family K03183 - 2.1.1.163,2.1.1.201 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005842 346.0
HKD2_k127_9562081_3 Beta-ketoacyl synthase, N-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003874 286.0
HKD2_k127_9562081_4 Phosphate acyltransferases - - - 0.00000000000000000000000000000000000000000000000004809 184.0
HKD2_k127_9562081_5 dehydratase - - - 0.000000000000000000000000000000000000000001208 162.0
HKD2_k127_9562081_6 Serine hydrolase involved in the detoxification of formaldehyde - - - 0.0000000000000000000000000000001717 133.0
HKD2_k127_9562081_7 - - - - 0.00000000000000000000000001486 114.0
HKD2_k127_9562081_8 - - - - 0.000000000000000749 84.0
HKD2_k127_9562081_9 MMPL family - - - 0.0000004698 52.0
HKD2_k127_9661083_0 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3) component and related enzymes K00382 - 1.8.1.4 3.766e-210 662.0
HKD2_k127_9661083_1 Class II Aldolase and Adducin N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000545 436.0
HKD2_k127_9661083_2 PFAM peptidase U61, LD-carboxypeptidase A K01297 - 3.4.17.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000005312 278.0
HKD2_k127_9661083_3 Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) K01563,K11991 - 3.5.4.33,3.8.1.5 0.0000000000000000000000000000000000000000000000000000000000000000007939 240.0
HKD2_k127_9661083_4 PFAM regulatory protein TetR - - - 0.0000000000000000000000000000000000000000000000000000000000000005734 224.0
HKD2_k127_9661083_5 PFAM ABC transporter related K01996 - - 0.000000000000000000000000000000000000000000000000000000008806 199.0
HKD2_k127_9661083_6 Spore Coat Protein U domain - - - 0.0006801 49.0
HKD2_k127_9673425_0 Belongs to the RtcB family K14415,K18148 - 6.5.1.3 1.428e-224 704.0
HKD2_k127_9673425_1 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation K00549 - 2.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 550.0
HKD2_k127_9673425_10 Methyltransferase domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001265 324.0
HKD2_k127_9673425_11 Protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001666 332.0
HKD2_k127_9673425_12 ATPase family associated with various cellular activities (AAA) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 303.0
HKD2_k127_9673425_13 Biotin-lipoyl like K01993 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004871 283.0
HKD2_k127_9673425_14 ABC-2 type transporter K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000009575 271.0
HKD2_k127_9673425_15 NnrU protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000005329 253.0
HKD2_k127_9673425_16 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins K00573 - 2.1.1.77 0.00000000000000000000000000000000000000000000000000000000000000000000000008292 256.0
HKD2_k127_9673425_17 Dienelactone hydrolase K07100 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001821 253.0
HKD2_k127_9673425_18 phosphoribosyltransferase K07100 - - 0.000000000000000000000000000000000000000000000000000000000000000000001826 242.0
HKD2_k127_9673425_19 Sensors of blue-light using FAD - - - 0.000000000000000000000000000000000000000000000000000000000000000004659 228.0
HKD2_k127_9673425_2 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007858 516.0
HKD2_k127_9673425_20 Transcriptional regulator K21747 - - 0.000000000000000000000000000000000000000000000000000000000001684 227.0
HKD2_k127_9673425_21 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000001221 209.0
HKD2_k127_9673425_22 Nuclease (SNase domain protein) - - - 0.0000000000000000000000000000000000000000000002308 172.0
HKD2_k127_9673425_23 tetR family - - - 0.00000000000000000000000000000000000000000000403 171.0
HKD2_k127_9673425_24 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.0000000000000000000000000000000000000000000734 167.0
HKD2_k127_9673425_25 Archease protein family (MTH1598/TM1083) - - - 0.0000000000000000000000000000000000000000008309 162.0
HKD2_k127_9673425_26 Acyl dehydratase - - - 0.0000000000000000000000000000000000000005001 155.0
HKD2_k127_9673425_27 Tellurite resistance protein TerB - - - 0.0000000000000000000000000000000000001847 161.0
HKD2_k127_9673425_28 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate K03179,K17105 - 2.5.1.39,2.5.1.42 0.00000000000000000000000000000000000032 155.0
HKD2_k127_9673425_29 Glycine-zipper domain - - - 0.0000000000000000000000000000000000008198 149.0
HKD2_k127_9673425_3 Nicotinate phosphoribosyltransferase (NAPRTase) family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003413 527.0
HKD2_k127_9673425_30 COG2010 Cytochrome c, mono- and diheme variants - - - 0.000000000000000000000000000000000004262 142.0
HKD2_k127_9673425_31 Diacylglycerol kinase catalytic domain - - - 0.0000000000000000000000000000000002595 147.0
HKD2_k127_9673425_32 HicA toxin of bacterial toxin-antitoxin, - - - 0.000000000000000000000000001316 116.0
HKD2_k127_9673425_33 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 K00946 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 0.000000000000000000000008168 115.0
HKD2_k127_9673425_34 - - - - 0.000000000000000000003297 96.0
HKD2_k127_9673425_35 Protein of unknown function (DUF4236) - - - 0.00000000000000000003673 103.0
HKD2_k127_9673425_36 - - - - 0.0000000000000001163 84.0
HKD2_k127_9673425_37 Cysteine-rich CWC - - - 0.00000001294 60.0
HKD2_k127_9673425_4 Catalyzes the formation of 2-oxobutanoate from L-threonine or the formation of pyruvate from serine K01754 - 4.3.1.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005644 498.0
HKD2_k127_9673425_5 aldo keto reductase K19265 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001153 494.0
HKD2_k127_9673425_6 PFAM ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007281 407.0
HKD2_k127_9673425_7 GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007324 374.0
HKD2_k127_9673425_8 Acyl-transferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002745 365.0
HKD2_k127_9673425_9 Phosphoribosyl synthetase-associated domain K00948 - 2.7.6.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002314 339.0
HKD2_k127_9677927_0 dehydrogenase, E1 component K00164 - 1.2.4.2 0.0 1555.0
HKD2_k127_9677927_1 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 1.01e-319 989.0
HKD2_k127_9677927_2 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg K00174 - 1.2.7.11,1.2.7.3 3.872e-305 951.0
HKD2_k127_9677927_3 The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004706 599.0
HKD2_k127_9677927_4 Dehydrogenase K00382 GO:0003674,GO:0003824,GO:0004148,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006139,GO:0006163,GO:0006164,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018130,GO:0018335,GO:0019362,GO:0019438,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0031974,GO:0031981,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036211,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0046390,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061732,GO:0070013,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0072524,GO:0090407,GO:0106077,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902494,GO:1990204,GO:1990234 1.8.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003498 368.0
HKD2_k127_9677927_5 PFAM Thiamine pyrophosphate K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000000000000000000002721 143.0
HKD2_k127_9717495_0 ERAP1-like C-terminal domain K01256 - 3.4.11.2 1.219e-207 676.0
HKD2_k127_9717495_10 Domain of unknown function (DUF4124) - - - 0.0008962 48.0
HKD2_k127_9717495_2 PFAM AAA ATPase central domain protein K01338 - 3.4.21.53 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002104 436.0
HKD2_k127_9717495_3 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000283 391.0
HKD2_k127_9717495_4 cytochrome P450 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002205 377.0
HKD2_k127_9717495_5 - - - - 0.0000000000000000000000000000000000000000000000000000001801 215.0
HKD2_k127_9717495_6 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000000000000000000000000000000000003016 164.0
HKD2_k127_9717495_7 COG3278 Cbb3-type cytochrome oxidase, subunit 1 - - - 0.0000000000000000000000000000002268 128.0
HKD2_k127_9717495_8 Type IV pilus biogenesis stability protein PilW - - - 0.0000000000000000000000000008708 116.0
HKD2_k127_9717495_9 KTSC domain - - - 0.0000000000000002381 93.0
HKD2_k127_9770860_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 1.358e-216 683.0
HKD2_k127_9770860_1 PFAM conserved - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005086 424.0
HKD2_k127_9770860_2 FAD dependent oxidoreductase K00111 - 1.1.5.3 0.00000000002376 66.0
HKD2_k127_9911055_0 efflux pump K18138 - - 1.11e-286 913.0
HKD2_k127_9911055_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 295.0
HKD2_k127_9911055_2 Prolyl 4-hydroxylase alpha subunit homologues. K00472 - 1.14.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000002165 263.0
HKD2_k127_9911055_3 RND efflux system, outer membrane lipoprotein, NodT family K18139 - - 0.00000001208 68.0