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Overview

ID MAG01808
Name HKD2_bin.61
Sample SMP0047
Taxonomy
Kingdom Bacteria
Phylum Acidobacteriota
Class Vicinamibacteria
Order Fen-336
Family Fen-336
Genus
Species
Assembly information
Completeness (%) 68.73
Contamination (%) 3.24
GC content (%) 73.0
N50 (bp) 2,456
Genome size (bp) 2,627,753

Location

Module

Module ID Module name Total genes Total steps Contain genes Contain steps Percentage of genes Percentage of steps

Genes2656

Gene name Description KEGG GOs EC E-value Score Sequence
HKD2_k127_10007796_0 amino acid K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001512 380.0
HKD2_k127_10007796_1 amino acid K03294 - - 0.0000000000000003804 93.0
HKD2_k127_10007796_2 - - - - 0.00000003811 61.0
HKD2_k127_10015877_0 AcrB/AcrD/AcrF family - - - 1.018e-241 792.0
HKD2_k127_10015877_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.00000000000000000000000000000000000000000000000267 190.0
HKD2_k127_10017762_0 PFAM Amino acid permease K03294 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001335 506.0
HKD2_k127_10017762_1 NeuB family K03856 - 2.5.1.54 0.00000000000000000000000000000000000000000000000000000000000000001676 230.0
HKD2_k127_10017910_0 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000000000000000000000000000001723 211.0
HKD2_k127_10017910_1 PFAM peptidase S1 and S6, chymotrypsin Hap K08070 - 1.3.1.74 0.00002406 56.0
HKD2_k127_10032386_0 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.00000000000000000000001444 101.0
HKD2_k127_10032386_1 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016020,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 0.00000000000000000000004113 110.0
HKD2_k127_10032386_2 Type IV pilus biogenesis stability protein PilW K02656 - - 0.0001352 52.0
HKD2_k127_10033299_0 Cytochrome c - - - 1.036e-198 625.0
HKD2_k127_10033299_1 Cytochrome C oxidase subunit II, periplasmic domain K00376 - 1.7.2.4 0.0000000000000000000000005074 111.0
HKD2_k127_10052700_0 COG2366 Protein related to penicillin acylase K07116 - 3.5.1.97 7.78e-313 979.0
HKD2_k127_10052700_1 radical SAM domain protein K04070 - 1.97.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000007444 272.0
HKD2_k127_10052903_0 PFAM Glycosyl transferase, group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000172 219.0
HKD2_k127_10052903_1 Enoyl-(Acyl carrier protein) reductase K03793 - 1.5.1.33 0.00000000000000000000000000000000000000000005819 171.0
HKD2_k127_10052903_2 lipid kinase, YegS Rv2252 BmrU family - - - 0.00000000000000000000000000000000000000002175 173.0
HKD2_k127_10054199_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 496.0
HKD2_k127_10054199_1 Part of the ABC transporter complex PstSACB involved in phosphate import K02040 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010921,GO:0015698,GO:0019220,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031975,GO:0033554,GO:0035303,GO:0042301,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0065007,GO:0065009 - 0.00001043 51.0
HKD2_k127_10088317_0 transcription factor binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000186 468.0
HKD2_k127_10088317_1 Glucose dehydrogenase C-terminus - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001226 266.0
HKD2_k127_10088317_2 alcohol dehydrogenase - - - 0.0000000000000000000002297 99.0
HKD2_k127_10097175_0 TIGRFAM hydrogenase (NiFe) small subunit (hydA) K06282,K18008 - 1.12.2.1,1.12.99.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000725 372.0
HKD2_k127_10097175_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002849 354.0
HKD2_k127_10097175_2 PFAM Polysulphide reductase, NrfD - - - 0.00000000000000000000000000000000000000000009265 163.0
HKD2_k127_10099375_0 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA K01963 - 2.1.3.15,6.4.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002106 357.0
HKD2_k127_10101708_0 Glycosyl hydrolase 36 superfamily, catalytic domain K00702,K13688 - 2.4.1.20 2.679e-317 990.0
HKD2_k127_10101708_1 Glycosyl hydrolase 36 superfamily, catalytic domain K00702,K13688 - 2.4.1.20 0.0000000000000000002613 104.0
HKD2_k127_10105153_0 COG1629 Outer membrane receptor proteins, mostly Fe transport - - - 1.593e-228 732.0
HKD2_k127_10112641_0 Metallo-beta-lactamase superfamily K17837 - 3.5.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001887 316.0
HKD2_k127_10112641_1 rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality K07560 GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - 0.00000000000000000000000000000000000000000000003272 172.0
HKD2_k127_10112641_2 translation initiation inhibitor, yjgF family K04782 - 4.2.99.21 0.0000000000000000000000000000000000000000000001169 171.0
HKD2_k127_10112641_3 AcrB/AcrD/AcrF family K03296 - - 0.0000000001 64.0
HKD2_k127_10112842_0 TIGRFAM RNA polymerase sigma factor, sigma-70 family K03088 - - 0.0000000000000000000000000000000001673 139.0
HKD2_k127_10112842_1 - - - - 0.00000000007836 74.0
HKD2_k127_10112842_2 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000009502 60.0
HKD2_k127_10115535_0 nitrite transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003607 469.0
HKD2_k127_10115535_1 nitrite transmembrane transporter activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003544 271.0
HKD2_k127_10115535_2 Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) K00275 - 1.4.3.5 0.0000000000000000000000000000000000000000000000000000000000000000008697 234.0
HKD2_k127_10115535_3 GAF domain - - - 0.00000000000003996 85.0
HKD2_k127_10115535_4 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.000007771 58.0
HKD2_k127_10118128_0 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000002542 276.0
HKD2_k127_10118128_1 - - - - 0.0000000000000000000000000001248 128.0
HKD2_k127_10119524_0 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001115 358.0
HKD2_k127_10119524_1 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001531 352.0
HKD2_k127_10141240_0 Pfam Transposase IS66 - - - 0.0000000000000000000000000002229 122.0
HKD2_k127_10155677_0 PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP K20276 - - 0.000000000000000000000000000000000000000000000000000000000000000776 229.0
HKD2_k127_10155677_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000001367 118.0
HKD2_k127_10155677_2 Domain of unknown function (DUF362) - - - 0.000000000000000000000000148 119.0
HKD2_k127_10161737_0 AAA ATPase, central domain protein K07478 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004211 513.0
HKD2_k127_10161737_1 PFAM glutamine synthetase catalytic region K01915 - 6.3.1.2 0.000000000000000001257 87.0
HKD2_k127_10173544_0 ERAP1-like C-terminal domain K01256,K01263 - 3.4.11.14,3.4.11.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001411 289.0
HKD2_k127_10173544_1 SMART protein phosphatase 2C domain protein - - - 0.000000000000000000000000000000000000000000000009087 186.0
HKD2_k127_10182627_0 Aldehyde dehydrogenase family K00128,K00135 - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001278 578.0
HKD2_k127_10182627_1 Amidohydrolase family - - - 0.0000000000001454 83.0
HKD2_k127_1027004_0 PFAM Conserved region in glutamate synthase K00265 - 1.4.1.13,1.4.1.14 1.289e-212 672.0
HKD2_k127_1029360_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K03737 - 1.2.7.1 0.0 1121.0
HKD2_k127_1029360_1 RNA polymerase, sigma-24 subunit, ECF subfamily K03088 - - 0.00007818 50.0
HKD2_k127_1036241_0 aminopeptidase activity K01301 - 3.4.17.21 1.312e-249 792.0
HKD2_k127_1036241_1 Rubrerythrin - GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000061 253.0
HKD2_k127_1036241_2 Cysteine-rich domain K00113 - 1.1.5.3 0.000000000000000000000000000000000000000000000000000000001206 203.0
HKD2_k127_1036241_3 Ferric uptake regulator family K03711,K09825 - - 0.0000000000000000000000000000000000000005081 161.0
HKD2_k127_105740_0 SurA N-terminal domain K03770 - 5.2.1.8 0.00000000000000000000000000000000000000000000000000000000000000000004004 255.0
HKD2_k127_105740_1 PFAM FecR protein - - - 0.0000000000000000000000000000000000000001817 166.0
HKD2_k127_1062210_0 PFAM ATP-binding region ATPase domain protein - - - 0.00000000000000000000000000000000000000000005382 181.0
HKD2_k127_1062210_1 peptidyl-tyrosine sulfation - - - 0.000000000007103 75.0
HKD2_k127_1070769_0 COG0577 ABC-type antimicrobial peptide transport system permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 349.0
HKD2_k127_1077221_0 PFAM PfkB domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005171 400.0
HKD2_k127_1077221_1 Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates K00772 GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.28 0.000000000000000000000000000000000000000000000000000000001522 203.0
HKD2_k127_1077221_2 cAMP-dependent protein kinase regulatory subunit K04739 GO:0000166,GO:0000228,GO:0000785,GO:0000790,GO:0001932,GO:0001933,GO:0002831,GO:0002832,GO:0003674,GO:0004857,GO:0004860,GO:0004862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005886,GO:0005952,GO:0006469,GO:0006950,GO:0007154,GO:0008104,GO:0008150,GO:0008277,GO:0008603,GO:0009266,GO:0009267,GO:0009408,GO:0009605,GO:0009607,GO:0009628,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0010563,GO:0010570,GO:0010605,GO:0010646,GO:0010648,GO:0016020,GO:0017076,GO:0019207,GO:0019210,GO:0019220,GO:0019222,GO:0019887,GO:0023051,GO:0023057,GO:0030234,GO:0030291,GO:0030447,GO:0030551,GO:0030552,GO:0030554,GO:0031279,GO:0031281,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0031667,GO:0031668,GO:0031669,GO:0031974,GO:0031981,GO:0032101,GO:0032102,GO:0032104,GO:0032105,GO:0032107,GO:0032108,GO:0032268,GO:0032269,GO:0032386,GO:0032388,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032880,GO:0032991,GO:0033036,GO:0033157,GO:0033554,GO:0033673,GO:0034605,GO:0034613,GO:0036094,GO:0036170,GO:0036180,GO:0040007,GO:0040008,GO:0042325,GO:0042326,GO:0042594,GO:0043085,GO:0043086,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043549,GO:0043949,GO:0043951,GO:0044092,GO:0044093,GO:0044182,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044446,GO:0044454,GO:0044464,GO:0045744,GO:0045761,GO:0045762,GO:0045786,GO:0045859,GO:0045926,GO:0045936,GO:0046578,GO:0046580,GO:0046822,GO:0046824,GO:0046825,GO:0046827,GO:0048518,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051056,GO:0051058,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051246,GO:0051248,GO:0051338,GO:0051339,GO:0051348,GO:0051349,GO:0051445,GO:0051447,GO:0051641,GO:0051716,GO:0051726,GO:0060255,GO:0060258,GO:0060341,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070201,GO:0070727,GO:0071496,GO:0071900,GO:0071901,GO:0071944,GO:0080090,GO:0080134,GO:0090087,GO:0090316,GO:0097159,GO:0097271,GO:0097367,GO:0098772,GO:0106070,GO:0106072,GO:0110033,GO:0110034,GO:1900428,GO:1900429,GO:1900434,GO:1900435,GO:1900443,GO:1900444,GO:1901265,GO:1901363,GO:1902531,GO:1902532,GO:1902659,GO:1902660,GO:1903827,GO:1903829,GO:1904951,GO:2000241,GO:2000242,GO:2000479,GO:2000480 - 0.00000000004793 67.0
HKD2_k127_1086486_0 Amidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003609 298.0
HKD2_k127_1086486_1 PFAM Phosphoglycerate mutase K08296 - - 0.00000000000000000001043 105.0
HKD2_k127_1086486_2 lyase activity - - - 0.000001245 57.0
HKD2_k127_1103705_0 Transport permease protein K01992 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944 - 0.000000000000000000000000000000000000000306 153.0
HKD2_k127_1103705_1 - - - - 0.0000000000000000000000002166 121.0
HKD2_k127_1109742_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 8.449e-229 731.0
HKD2_k127_1127967_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003067 368.0
HKD2_k127_1141156_0 Cytochrome C and Quinol oxidase polypeptide I K00404 - 1.9.3.1 2.337e-206 682.0
HKD2_k127_1141156_1 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002318 523.0
HKD2_k127_1141156_2 Cytochrome C oxidase, mono-heme subunit/FixO K00405 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000195 269.0
HKD2_k127_1141156_3 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.0000000000000000000000001181 107.0
HKD2_k127_1145125_0 Belongs to the DEAD box helicase family K03732,K05592 - 3.6.4.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000002347 271.0
HKD2_k127_1145125_1 - - - - 0.0000792 51.0
HKD2_k127_1159111_0 cAMP biosynthetic process - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003789 362.0
HKD2_k127_1159111_1 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000001269 219.0
HKD2_k127_1159111_2 DinB family - - - 0.000000000000000000000000001505 113.0
HKD2_k127_1159567_0 Exonuclease of the beta-lactamase fold involved in RNA processing K07576 - - 0.0000000000000000000000000000000000000000000000000000000001024 211.0
HKD2_k127_1159567_1 Bacterial membrane protein, YfhO - - - 0.0000007763 58.0
HKD2_k127_1159814_0 Alg9-like mannosyltransferase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000001472 265.0
HKD2_k127_1159814_1 domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001655 254.0
HKD2_k127_1159814_2 HIT domain K02503 - - 0.000000000000000000000000000000000000000000000000000000000001875 209.0
HKD2_k127_1178271_0 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) K02492 - 1.2.1.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004364 353.0
HKD2_k127_1178271_1 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps K01749 GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000008911 310.0
HKD2_k127_1199519_0 Pyridoxal-dependent decarboxylase conserved domain K01593,K13745 - 4.1.1.105,4.1.1.28,4.1.1.86 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001685 447.0
HKD2_k127_1199519_1 COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - 0.00000000000000000000000000000000000000000000000000000000008938 216.0
HKD2_k127_1199519_2 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000005499 215.0
HKD2_k127_1199519_3 - - - - 0.00000000000000000000000000000001489 148.0
HKD2_k127_1199519_4 Pfam:N_methyl_2 - - - 0.000000000005382 74.0
HKD2_k127_1199519_5 lipolytic protein G-D-S-L family - - - 0.00000004537 62.0
HKD2_k127_1201179_0 Phosphofructokinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 623.0
HKD2_k127_121643_0 Putative ATP-binding cassette K01992 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001478 321.0
HKD2_k127_121643_1 AAA domain, putative AbiEii toxin, Type IV TA system K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000004714 294.0
HKD2_k127_121643_2 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate K03526 GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 0.000000000000000000000000000000000000000005327 178.0
HKD2_k127_121643_3 PFAM transglutaminase domain protein - - - 0.000000000000000000000000000000000006656 147.0
HKD2_k127_1220520_0 Rubrerythrin K22405 - 1.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001535 340.0
HKD2_k127_1220520_1 rubredoxin K22405 - 1.6.3.4 0.000000000000000000000000000000000000000002909 160.0
HKD2_k127_1220520_2 Cytochrome c K00405 - - 0.00000000009672 70.0
HKD2_k127_1221385_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002539 409.0
HKD2_k127_1221385_1 flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase K07006 - - 0.000000000000000000000000000000000000000000000000000000000004888 220.0
HKD2_k127_1221385_2 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate K00940 - 2.7.4.6 0.0000000000000000000000000000000000000000000000000000006969 196.0
HKD2_k127_1221385_3 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000001328 65.0
HKD2_k127_1221385_4 Peptidase S9 prolyl oligopeptidase active site domain protein - - - 0.00001983 49.0
HKD2_k127_1256621_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000002147 144.0
HKD2_k127_1256621_1 tetratricopeptide repeat - - - 0.000000000000000001297 96.0
HKD2_k127_1261463_0 PhoH-like protein K06217 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002192 330.0
HKD2_k127_1261463_1 PFAM CBS domain containing protein K06189 - - 0.0000000000000000000000000000000000000000000002274 184.0
HKD2_k127_1261463_2 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA K07042 - - 0.00000000000000000000000000229 126.0
HKD2_k127_1261463_3 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.0000000000000004922 88.0
HKD2_k127_1265049_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 375.0
HKD2_k127_1265049_1 - K11891,K16091 - - 0.00005047 47.0
HKD2_k127_1266585_0 Sigma-54 interaction domain K15836 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000501 361.0
HKD2_k127_1266585_1 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K02030 - - 0.0000000000000000000000000000000000000000000000000000000000000000000006131 249.0
HKD2_k127_1266585_2 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K02030 - - 0.000000000000000000000000000000002571 138.0
HKD2_k127_1270155_0 polygalacturonase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002272 379.0
HKD2_k127_127813_0 PEP-utilising enzyme, mobile domain K01006 - 2.7.9.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006397 510.0
HKD2_k127_127813_1 Glycyl-tRNA synthetase beta subunit K01879 - 6.1.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000001527 262.0
HKD2_k127_1280885_0 Homocysteine S-methyltransferase K00297,K00547,K00548 - 1.5.1.20,2.1.1.10,2.1.1.13 0.000000000000000000000000000000000000000000000000000245 194.0
HKD2_k127_1280885_1 Trimethylamine methyltransferase (MTTB) K14083 - 2.1.1.250 0.000000000000000000000000001562 121.0
HKD2_k127_1280885_2 Vitamin B12 dependent methionine synthase, activation domain - - - 0.0000000001428 74.0
HKD2_k127_1287460_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K15727 - - 0.0000000000000000000000000000000000000000000000000000000000005677 222.0
HKD2_k127_1287460_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000146 204.0
HKD2_k127_1322106_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 3.333e-248 787.0
HKD2_k127_1322106_1 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.000000000000000002085 89.0
HKD2_k127_1324373_0 COGs COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs K12528 - - 6.854e-289 917.0
HKD2_k127_1324373_1 Peroxiredoxin K03386 - 1.11.1.15 0.00000000000000000000000000000000000000000000000000000000003772 209.0
HKD2_k127_1324373_2 PFAM 2Fe-2S -binding K03518,K13483 - 1.2.5.3 0.000000000000000000000000000000000000000000009935 170.0
HKD2_k127_1335117_0 tRNA-splicing ligase RtcB K14415 - 6.5.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001145 460.0
HKD2_k127_1335117_1 3'(2'),5'-bisphosphate nucleotidase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001599 287.0
HKD2_k127_1335117_3 Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) K01265 - 3.4.11.18 0.000000000000000000000000000000000000000000000000337 188.0
HKD2_k127_1335117_4 PFAM Cold-shock protein, DNA-binding K03704 - - 0.000000000000000000000000002904 111.0
HKD2_k127_1335117_5 Dihydrouridine synthase (Dus) - - - 0.0000000004122 62.0
HKD2_k127_1337660_0 Molydopterin dinucleotide binding domain K08352 - 1.8.5.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002208 541.0
HKD2_k127_1357209_0 L-lysine 6-monooxygenase (NADPH-requiring) K00384 - 1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008603 338.0
HKD2_k127_1357209_1 Saccharopine dehydrogenase - - - 0.00000000000000000000000000000000000000000000000000003761 193.0
HKD2_k127_1357209_2 Periplasmic component of the Tol biopolymer transport system - - - 0.00000000000001438 79.0
HKD2_k127_1370680_0 phosphorelay signal transduction system K02481,K07713,K07714 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002608 347.0
HKD2_k127_1370680_1 MASE1 - - - 0.00000000000000000000000000000000000002298 158.0
HKD2_k127_1374141_0 Beta-ketoacyl synthase, C-terminal domain K14660 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003005 398.0
HKD2_k127_1374141_1 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell K02536 - 2.3.1.191 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000007537 295.0
HKD2_k127_1378679_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03040 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004016 464.0
HKD2_k127_1378679_1 Ribosomal protein L17 K02879 - - 0.00000000000000000004024 97.0
HKD2_k127_1378693_0 YcaO cyclodehydratase, ATP-ad Mg2+-binding K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004766 410.0
HKD2_k127_1378693_1 bacteriocin biosynthesis docking scaffold, SagD family K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001138 256.0
HKD2_k127_1382246_0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) K01866 - 6.1.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000004833 277.0
HKD2_k127_1382246_1 esterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001137 258.0
HKD2_k127_1397429_0 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 376.0
HKD2_k127_1397429_1 COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain K02483 - - 0.00000000000000000002109 107.0
HKD2_k127_1399592_0 TonB-dependent Receptor Plug Domain K02014,K16092 - - 0.000000000000000000000000000000000000000006937 170.0
HKD2_k127_1399592_1 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.00000000000000000000000000002542 126.0
HKD2_k127_1399719_0 Protein of unknown function (DUF2490) - - - 0.00000000000000000000002393 108.0
HKD2_k127_1399719_1 BON domain - - - 0.0000000000000000000008909 106.0
HKD2_k127_141628_0 Pfam:Arch_ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000001329 241.0
HKD2_k127_1434894_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K08352 - 1.8.5.5 2.986e-197 622.0
HKD2_k127_1434894_1 4 iron, 4 sulfur cluster binding K04014,K08353,K08358,K16293 GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016661,GO:0016662,GO:0030288,GO:0030313,GO:0031975,GO:0042279,GO:0042597,GO:0044464,GO:0055114,GO:0098809 - 0.0000000000000000000000000000000000000000000000000000000001544 205.0
HKD2_k127_1467742_0 Domain of Unknown Function with PDB structure (DUF3857) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000001771 272.0
HKD2_k127_1467742_1 - - - - 0.00000001249 57.0
HKD2_k127_1468682_0 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01533 - 3.6.3.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001327 421.0
HKD2_k127_1468682_1 4 iron, 4 sulfur cluster binding - - - 0.00000000000000000000000000000006204 134.0
HKD2_k127_1468682_2 Cytochrome C biogenesis protein transmembrane region K09792 - - 0.0000004646 63.0
HKD2_k127_1469574_0 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source K01950 - 6.3.5.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009828 460.0
HKD2_k127_1469574_1 PFAM glycosyl transferase, family 35 K00688 - 2.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003972 341.0
HKD2_k127_1469574_2 response regulator - - - 0.00001446 58.0
HKD2_k127_1498174_0 competence protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000007794 248.0
HKD2_k127_1498174_1 Belongs to the heat shock protein 70 family - - - 0.00000000000007322 73.0
HKD2_k127_1498174_3 - - - - 0.000004655 54.0
HKD2_k127_1498174_4 Glucose sorbosone - - - 0.000008955 54.0
HKD2_k127_1501434_0 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00821,K03918,K07250,K13524 - 2.6.1.11,2.6.1.17,2.6.1.19,2.6.1.22,2.6.1.36 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004097 488.0
HKD2_k127_1501434_1 Dihydrodipicolinate reductase, N-terminus K21672 - 1.4.1.12,1.4.1.26 0.0000000000000000000000000000000000000000000000001822 184.0
HKD2_k127_1501434_2 Cyclic nucleotide-binding domain - - - 0.000000000001529 73.0
HKD2_k127_1509408_0 Bacterial transferase hexapeptide (six repeats) - - - 0.0000000000000000000000000000000000000000000008968 174.0
HKD2_k127_1509408_1 oligopeptide transport K03305 - - 0.0000000000116 69.0
HKD2_k127_1509408_2 Dodecin K09165 - - 0.0000002077 52.0
HKD2_k127_1532940_0 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance K00951 - 2.7.6.5 8.387e-242 762.0
HKD2_k127_1532940_1 MotA TolQ ExbB proton channel K03561,K03562 - - 0.0000000000000000000000000000000000000000000000000000000000000002164 227.0
HKD2_k127_1532940_2 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.000000000000000000000000000000000000000000008528 171.0
HKD2_k127_1532940_3 endoribonuclease L-PSP K09022 - 3.5.99.10 0.00000000000000000000000000000000000000005607 154.0
HKD2_k127_1532940_4 PFAM Biopolymer transport protein ExbD TolR K03559,K03560 - - 0.0000000000000000000000001123 113.0
HKD2_k127_1532940_5 Gram-negative bacterial TonB protein C-terminal K03832 - - 0.0000000000000000000001724 103.0
HKD2_k127_1532940_6 biopolymer transport protein K03559,K03560 - - 0.0000000000000000000008328 100.0
HKD2_k127_1549227_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 8.233e-266 826.0
HKD2_k127_1577915_0 Biotin-lipoyl like K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001503 352.0
HKD2_k127_1577915_1 methyl-accepting chemotaxis protein K07315 - 3.1.3.3 0.000001551 57.0
HKD2_k127_160467_0 Sporulation and spore germination - - - 0.0000000000000000001428 97.0
HKD2_k127_1617117_0 diguanylate cyclase - - - 0.00000000000000000000000000000000001433 154.0
HKD2_k127_1644551_0 Catalyzes the reversible phosphorylation of UMP to UDP K09903 - 2.7.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 323.0
HKD2_k127_1644551_1 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome K02357 GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - 0.00000000000000000000000000000000000000000000000000000000000000000002615 238.0
HKD2_k127_1644551_2 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.00000000000000000000000000000000000000000000000000000002939 210.0
HKD2_k127_1649908_0 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002075 515.0
HKD2_k127_1649908_1 Heat shock 70 kDa protein K04043 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002226 341.0
HKD2_k127_1653305_0 OPT oligopeptide transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006898 508.0
HKD2_k127_1653305_1 Peptidase family S51 K13282 - 3.4.15.6 0.000000000000000000000000000000000000000000000000000002886 213.0
HKD2_k127_1653305_2 Asparaginase K13051 - 3.4.19.5 0.0000000000000000000000000000000000000000000000007418 186.0
HKD2_k127_1653305_3 ferredoxin-NADP+ reductase activity - - - 0.00000000000000000000000000000000000000000000001449 176.0
HKD2_k127_1653305_4 manganese ion transmembrane transporter activity - - - 0.0000000000002627 79.0
HKD2_k127_1657756_0 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001502 486.0
HKD2_k127_1657756_1 Acyclic terpene utilisation family protein AtuA - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004097 445.0
HKD2_k127_1657756_2 Beta-lactamase - - - 0.000000000000000000000000000000000000000000000000506 183.0
HKD2_k127_1666097_0 transporter of a GTP-driven Fe(2 ) uptake system K04759 - - 1.271e-206 662.0
HKD2_k127_1666097_1 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.00000000000000000000000000000000000000000000000000000000000000000000000001044 254.0
HKD2_k127_1666097_2 PFAM iron dependent repressor K03709 - - 0.0000000000000000000000000000000000000000000006493 177.0
HKD2_k127_1666097_3 CBS domain K04767,K07168,K07182 - - 0.000000000000000000001266 100.0
HKD2_k127_1666097_4 Putative outer membrane beta-barrel porin, MtrB/PioB - - - 0.000000000005675 74.0
HKD2_k127_1666097_5 ferrous iron import across plasma membrane - - - 0.000001566 61.0
HKD2_k127_1667432_0 virulence factor Mce family protein K02067 - - 0.000000000000002461 86.0
HKD2_k127_1667432_1 YtxH-like protein - - - 0.00000008168 64.0
HKD2_k127_1676654_0 benzoyl-CoA oxygenase K15512 - 1.14.13.208 7.249e-213 687.0
HKD2_k127_1676654_1 Enoyl-CoA hydratase/isomerase K15513 - 4.1.2.44 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002948 612.0
HKD2_k127_1676654_2 ABC transporter, substrate-binding protein, family 5 - - - 0.00000000000000000000000007498 120.0
HKD2_k127_1682525_0 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006214 419.0
HKD2_k127_1682525_1 (ABC) transporter K06147,K18890 - - 0.0000000000000000000000000000000000000000000000000000000000000000001209 235.0
HKD2_k127_1682525_2 Belongs to the pseudouridine synthase RsuA family K06178,K06183 - 5.4.99.19,5.4.99.22 0.000000000000000000000000000000000000000000000000000000001871 209.0
HKD2_k127_1682525_3 Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs K02372 - 4.2.1.59 0.00000000000000000000000000000000000000002455 156.0
HKD2_k127_1682525_4 phosphatidylinositol metabolic process K13671 - - 0.0001554 54.0
HKD2_k127_1682525_5 PilZ domain - - - 0.0002104 54.0
HKD2_k127_1684817_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005232 341.0
HKD2_k127_1684817_1 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import K02007 - - 0.000000000000000009299 84.0
HKD2_k127_1685600_0 Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen K00525 - 1.17.4.1 1.948e-224 706.0
HKD2_k127_1688390_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001586 490.0
HKD2_k127_1688390_1 HEAT repeats - - - 0.00000000000000000000000009287 113.0
HKD2_k127_169233_0 PFAM RNA polymerase sigma factor 54, interaction - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006802 378.0
HKD2_k127_169233_1 COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006916 274.0
HKD2_k127_1700539_0 Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily K01465 - 3.5.2.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000179 274.0
HKD2_k127_1700539_1 Evidence 4 Homologs of previously reported genes of - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000804 282.0
HKD2_k127_1700539_2 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000008841 243.0
HKD2_k127_1704171_0 Putative diguanylate phosphodiesterase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005118 587.0
HKD2_k127_1704171_1 SPFH domain / Band 7 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003337 301.0
HKD2_k127_1704171_2 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 307.0
HKD2_k127_1704171_3 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 0.000000000005376 66.0
HKD2_k127_1704620_0 amino acid - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002213 490.0
HKD2_k127_1704620_1 DUF218 domain - - - 0.000000000001423 81.0
HKD2_k127_1706206_0 Histone deacetylase domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002603 281.0
HKD2_k127_1706206_1 electron transfer flavoprotein, alpha subunit K03522 - - 0.00000000000000000000000000000000000000000000000000000000000000000003796 237.0
HKD2_k127_1725557_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.000000000000000000000000000000000000000000000000000000000000005125 231.0
HKD2_k127_1725557_1 4Fe-4S dicluster domain - - - 0.00000000000000000000000000000003477 143.0
HKD2_k127_1736817_0 Signal Transduction Histidine Kinase - - - 0.000000000000008621 81.0
HKD2_k127_1755304_0 PA domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005506 299.0
HKD2_k127_1755304_1 - - - - 0.0000000000004512 77.0
HKD2_k127_1765221_0 Histidine kinase K00936,K19622,K20962 - 2.7.13.3,3.1.4.52 0.00000000000000000000000000000000000000000000000002627 193.0
HKD2_k127_1765221_1 ANTAR K22010 - - 0.000000000000000156 88.0
HKD2_k127_1766062_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001422 327.0
HKD2_k127_1766062_1 Flavin reductase like domain - - - 0.000000000004007 69.0
HKD2_k127_1786781_0 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 607.0
HKD2_k127_1786781_1 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.00003261 50.0
HKD2_k127_1786781_2 PFAM Rieske 2Fe-2S domain K02636,K03886 - 1.10.9.1 0.0003245 43.0
HKD2_k127_1800672_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.00000000000000000000000000000000000000000003719 165.0
HKD2_k127_1800672_1 HD domain - - - 0.00000000000000000000000000000000000000000006447 169.0
HKD2_k127_1800672_2 Protein of unknown function (DUF3641) - - - 0.0000000000000000000000000000000000000000214 162.0
HKD2_k127_1800672_3 MreB/Mbl protein K03569 - - 0.000000000000000000000000000001093 137.0
HKD2_k127_1800672_4 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - 0.000000000000000000000000003572 119.0
HKD2_k127_1806326_0 (ABC) transporter K15738 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001689 325.0
HKD2_k127_1806326_1 Sigma-70, region 4 K03088 - - 0.000000000000000000000000000000000000000000000000000000000001891 228.0
HKD2_k127_1806326_2 GTP cyclohydrolase I K01495 - 3.5.4.16 0.000000000000000000000000000000000000000000006356 187.0
HKD2_k127_1814639_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001735 489.0
HKD2_k127_1823050_0 involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane K09774 - - 0.00000001561 67.0
HKD2_k127_1826546_0 cAMP biosynthetic process K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000001317 211.0
HKD2_k127_1826546_1 Endonuclease Exonuclease Phosphatase - - - 0.000005563 50.0
HKD2_k127_1828391_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004491 339.0
HKD2_k127_1828391_1 Aminotransferase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004965 314.0
HKD2_k127_1828391_2 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000000000000000000000000000000000000000000000000000000000283 228.0
HKD2_k127_1850861_0 Mazg nucleotide pyrophosphohydrolase - - - 0.0000000000000378 81.0
HKD2_k127_1850861_1 Transcription factor WhiB - - - 0.0003759 47.0
HKD2_k127_1854616_0 HD domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006717 442.0
HKD2_k127_1854616_1 TonB dependent receptor K02014 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002532 363.0
HKD2_k127_1854616_2 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.00000000000000000000000000000000000000000000000000001494 197.0
HKD2_k127_1854616_3 - - - - 0.0000000000000001117 88.0
HKD2_k127_1855790_0 transcriptional regulatory protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005298 291.0
HKD2_k127_1855790_1 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB K03550 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000006151 196.0
HKD2_k127_1855790_2 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group K01159 - 3.1.22.4 0.000000000000000000000000000000000001638 153.0
HKD2_k127_1855790_3 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing K03551 - 3.6.4.12 0.00000000000000000000000000001618 124.0
HKD2_k127_1855790_4 Spermine/spermidine synthase domain - - - 0.000000000001507 74.0
HKD2_k127_1871911_0 PFAM Sulfatase - - - 0.000005122 53.0
HKD2_k127_1871911_1 GGDEF domain - - - 0.0009708 51.0
HKD2_k127_1876624_0 ABC transporter K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003203 346.0
HKD2_k127_1876624_1 MacB-like periplasmic core domain K02004 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002548 329.0
HKD2_k127_1884928_0 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family K03218 - 2.1.1.185 0.000000000000000000000000000000000000000000000000000000000000001093 232.0
HKD2_k127_1884928_1 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) K01770 - 4.6.1.12 0.0000000000000000000000000000000000000000000000001398 191.0
HKD2_k127_1884928_2 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) K00991 - 2.7.7.60 0.0000000000000000000000000000000000000008682 155.0
HKD2_k127_1914856_0 Large extracellular alpha-helical protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002626 505.0
HKD2_k127_1929726_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 9.721e-288 904.0
HKD2_k127_1929726_1 PFAM membrane bound O-acyl transferase MBOAT K19294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003273 431.0
HKD2_k127_1929726_2 SGNH hydrolase-like domain, acetyltransferase AlgX - - - 0.000000000000000000000000000000000000000481 171.0
HKD2_k127_1929726_3 - - - - 0.0000000000000000000000006249 118.0
HKD2_k127_1929726_4 RNA-binding protein K07574 - - 0.0000000000000000001371 99.0
HKD2_k127_1929726_5 Redoxin K03564 - 1.11.1.15 0.0000000000000959 74.0
HKD2_k127_1932386_0 - - - - 3.358e-235 741.0
HKD2_k127_1932386_1 TGS domain K06944 - - 0.000000000001504 68.0
HKD2_k127_1937908_0 fatty acid beta-oxidation using acyl-CoA dehydrogenase K03522 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001401 348.0
HKD2_k127_1937908_1 Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002585 246.0
HKD2_k127_1937908_2 AdoMet dependent proline di-methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000001646 241.0
HKD2_k127_1937908_3 Protein conserved in bacteria - - - 0.0000000000000000000000000000000000000000000004504 179.0
HKD2_k127_1937908_4 glycolate biosynthetic process K01091,K06019,K13292 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.1.3.18,3.6.1.1 0.0000000000000000000000000000000000006125 147.0
HKD2_k127_1937908_5 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system K09803 - - 0.0000000000000006129 80.0
HKD2_k127_1948096_0 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX K03405 - 6.6.1.1 1.533e-194 619.0
HKD2_k127_1948096_1 von Willebrand factor (vWF) type A domain K07114 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001444 317.0
HKD2_k127_1948096_2 PFAM Adenosine specific kinase K09129 - - 0.0000000000000000000000000000000000000000000000000000000000000006641 222.0
HKD2_k127_1948096_3 Nitroreductase family - - - 0.000000000000000000000000000000000000000000000002337 181.0
HKD2_k127_1948942_0 Aldehyde dehydrogenase family K22445 - 1.2.99.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003595 283.0
HKD2_k127_1948942_1 Thioredoxin - - - 0.000000000000000000848 91.0
HKD2_k127_1959281_0 PFAM Lipocalin family protein K03098 - - 0.0000000000000000000000000000000000000000000017 172.0
HKD2_k127_1959281_1 Cupin domain - - - 0.0000000000000000000000000000000007417 143.0
HKD2_k127_1959281_2 - - - - 0.000000000000000000001895 100.0
HKD2_k127_1959281_3 Acyltransferase - - - 0.00002565 55.0
HKD2_k127_199735_0 Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) K00912 - 2.7.1.130 0.00000000000000000000000000000000000000000000000001362 194.0
HKD2_k127_199735_1 transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.00002852 48.0
HKD2_k127_199735_2 Lipid A biosynthesis acyltransferase K02517 - 2.3.1.241 0.0003908 52.0
HKD2_k127_1998278_0 Protein of unknown function (DUF3501) - - - 0.0000000000000000000000000000000000000000000000000000000000005421 220.0
HKD2_k127_1998278_1 Cysteine-rich domain K00113 - 1.1.5.3 0.0000000000000000000000000000001115 125.0
HKD2_k127_1998278_2 TIGRFAM Diguanylate cyclase - - - 0.00000002701 64.0
HKD2_k127_2000385_0 Carboxyl transferase domain K01966 - 2.1.3.15,6.4.1.3 3.122e-250 781.0
HKD2_k127_2000385_1 Biotin carboxylase C-terminal domain K01961 - 6.3.4.14,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 588.0
HKD2_k127_2000385_2 Biotin-requiring enzyme - - - 0.00000000000000000000000006133 113.0
HKD2_k127_2006478_0 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005928 374.0
HKD2_k127_2006478_1 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000003527 139.0
HKD2_k127_2021842_0 MacB-like periplasmic core domain K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000037 491.0
HKD2_k127_2021842_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007304 413.0
HKD2_k127_2040327_0 ABC-2 family transporter protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009086 326.0
HKD2_k127_2040327_1 translation initiation factor activity K06996 - - 0.000000000000000000000000000003204 137.0
HKD2_k127_2044683_0 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin K00174 - 1.2.7.11,1.2.7.3 8.288e-246 776.0
HKD2_k127_2044683_1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain K00175 - 1.2.7.11,1.2.7.3 0.00000000000000000000127 96.0
HKD2_k127_2048384_0 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides K01255 - 3.4.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001444 266.0
HKD2_k127_2048384_1 MacB-like periplasmic core domain K02003,K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000002135 267.0
HKD2_k127_2048384_2 ATPases associated with a variety of cellular activities K02003 - - 0.0000000000000000000000000000000000000000000000000000000000000000001674 238.0
HKD2_k127_2048384_3 PFAM Dual specificity protein phosphatase - - - 0.0000000000001243 77.0
HKD2_k127_2051851_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008229 410.0
HKD2_k127_2053714_0 oxidoreductase K00311,K00313 - 1.5.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008415 509.0
HKD2_k127_2053714_1 electron transfer activity K03521 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007958 340.0
HKD2_k127_2056273_0 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain K04042 - 2.3.1.157,2.7.7.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001792 347.0
HKD2_k127_2056273_1 Tetratricopeptide repeat - - - 0.0000000005807 66.0
HKD2_k127_2065716_0 Memo-like protein K06990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002949 308.0
HKD2_k127_2065716_1 Radical SAM superfamily K04069 - 1.97.1.4 0.000000000000000000000000000000000000000000000000000000000000002037 222.0
HKD2_k127_2069241_0 Domain of unknown function (DUF4956) - - - 0.000000000000000000000002025 115.0
HKD2_k127_2069241_1 Acid phosphatase homologues - - - 0.0000000000000002277 89.0
HKD2_k127_2069241_2 - - - - 0.000000000005175 69.0
HKD2_k127_2088200_0 Ami_3 K01448 - 3.5.1.28 0.0000000000000000000000000000000000000000000000000002231 204.0
HKD2_k127_2088200_1 protein conserved in bacteria - - - 0.000000000000000000000000000000000000000000000002651 182.0
HKD2_k127_2104563_0 ABC transporter transmembrane K11085 - - 4.423e-245 769.0
HKD2_k127_2111602_0 TIGRFAM amino acid adenylation domain - - - 1.452e-242 772.0
HKD2_k127_2111602_1 PFAM AMP-dependent synthetase ligase - - - 0.000000000000000002189 88.0
HKD2_k127_2119614_0 threonyl-tRNA aminoacylation K01881 - 6.1.1.15 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005711 467.0
HKD2_k127_2119614_1 membrane protein, TerC K05794 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003958 402.0
HKD2_k127_2143173_0 Acid phosphatase homologues - - - 0.00000004122 63.0
HKD2_k127_2143173_1 Lipid A 3-O-deacylase (PagL) - - - 0.000005839 58.0
HKD2_k127_2155245_0 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006123 382.0
HKD2_k127_2155245_1 Flavin-nucleotide-binding protein K07005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000004849 260.0
HKD2_k127_2184284_0 Ppx GppA phosphatase family K01524 - 3.6.1.11,3.6.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002818 343.0
HKD2_k127_2184284_1 Cytochrome c K02305,K07152 - - 0.0000000000000000605 90.0
HKD2_k127_2184284_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000846 74.0
HKD2_k127_2205712_0 PFAM major facilitator superfamily MFS_1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002467 435.0
HKD2_k127_2205712_1 Fumarase C C-terminus K01744 - 4.3.1.1 0.000000000000000000000000000000000000000000001204 167.0
HKD2_k127_2212236_0 Polysulphide reductase, NrfD K00185 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004116 431.0
HKD2_k127_2212236_1 FAD binding domain - - - 0.0000000000000000000000000000000000000000000000004274 186.0
HKD2_k127_2213241_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000002041 282.0
HKD2_k127_2213241_1 TIGRFAM GTP cyclohydrolase I K01495 - 3.5.4.16 0.0000000000000000000000000000000000000000000000000000000000000000000004768 260.0
HKD2_k127_2213241_2 Radical SAM domain protein - - - 0.0000000000000000000000003025 118.0
HKD2_k127_2213241_3 PFAM Glycosyl transferase family 2 - - - 0.0000000000000000000001895 103.0
HKD2_k127_2213615_0 PFAM Aminotransferase class I and II K00812,K14260 - 2.6.1.1,2.6.1.2,2.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004392 415.0
HKD2_k127_2213615_1 translation release factor activity K15034 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - 0.0000000000000000000001919 99.0
HKD2_k127_2219435_0 Membrane transport protein K07088 - - 0.00000000000000000000000000000000000000000000000000000000000000000004035 243.0
HKD2_k127_2219435_1 Diguanylate cyclase - - - 0.0000000000000000000000000003469 131.0
HKD2_k127_2220012_0 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes K07738 - - 0.000000000000000000000000000000000000000000000000000000000816 217.0
HKD2_k127_2220012_1 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.000000001084 68.0
HKD2_k127_2220891_0 TilS substrate binding domain K04075 - 6.3.4.19 0.0000000000000000000000000000000000000000000000000000000000000007581 236.0
HKD2_k127_2220891_1 Belongs to the ALAD family K01698 GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 0.00000000000000000000000000000000000000000001456 168.0
HKD2_k127_2220891_2 Belongs to the purine pyrimidine phosphoribosyltransferase family K00760 - 2.4.2.8 0.00000000000000000000000000000000006067 153.0
HKD2_k127_2221860_0 Sulfatase - - - 0.00000000000000002854 96.0
HKD2_k127_2222231_0 PFAM Forkhead-associated protein - - - 0.00000000000000008218 89.0
HKD2_k127_2222231_1 PEGA domain - - - 0.000000878 60.0
HKD2_k127_2222231_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.0001967 53.0
HKD2_k127_2224818_0 palmitoyl-(protein) hydrolase activity K06999 - - 0.000000000000000000000000000000000000000000000000000000000001931 226.0
HKD2_k127_2224818_1 YHS domain - - - 0.000007976 48.0
HKD2_k127_2227021_0 reductase K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000003948 192.0
HKD2_k127_2227021_1 Benzoyl-CoA reductase subunit K04115 - 1.3.7.8 0.00000000000000000000000000000000003391 137.0
HKD2_k127_2227021_2 Acetyltransferase (GNAT) family - - - 0.0000000000000000000000000000677 132.0
HKD2_k127_2227021_3 Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins K13643 - - 0.0000000003823 70.0
HKD2_k127_222899_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000009974 153.0
HKD2_k127_222899_1 PQQ enzyme repeat - - - 0.000000000000000000003924 106.0
HKD2_k127_222899_2 MacB-like periplasmic core domain K02004 - - 0.0000004643 60.0
HKD2_k127_2231318_0 Uracil-DNA glycosylase K21929 - 3.2.2.27 0.00000000000000000000000000000000000000000000000000000000000000001256 241.0
HKD2_k127_2231318_1 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.000000000000000000000000000000000000000000000000000000000003209 214.0
HKD2_k127_2231318_2 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 - - 0.00000000000000000000000000000000000002125 155.0
HKD2_k127_2239675_0 oxoglutarate dehydrogenase (succinyl-transferring) activity K00164,K01616 GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2,4.1.1.71 2.788e-219 694.0
HKD2_k127_2247016_0 membrane transporter protein K07090 - - 0.0000000000000000000000000000000000000000000000005345 185.0
HKD2_k127_2247016_1 Thioesterase-like superfamily K01075 - 3.1.2.23 0.000000000000000007279 90.0
HKD2_k127_2247016_2 Protein of unknown function (DUF1634) - - - 0.00001895 55.0
HKD2_k127_2247016_3 Creatinine amidohydrolase K01470 - 3.5.2.10 0.0001959 44.0
HKD2_k127_2254240_0 Protein of unknown function (DUF1579) - - - 0.000000000000000000000000000000000000000009163 161.0
HKD2_k127_2254240_1 COGs COG2380 conserved - - - 0.000000000000000000000003525 113.0
HKD2_k127_2255775_0 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001033 301.0
HKD2_k127_2255775_1 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000005141 278.0
HKD2_k127_2272456_0 ATP synthesis coupled electron transport K00342,K00343,K05568 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001744 551.0
HKD2_k127_2272456_1 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000002599 293.0
HKD2_k127_2278125_0 Cytochrome D1 heme domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008613 509.0
HKD2_k127_2278125_1 Bacterial membrane protein YfhO - - - 0.0000000000000000000000000000000000000002628 172.0
HKD2_k127_2278125_2 Transcriptional regulatory protein, C terminal K02483 - - 0.000000000000000000006899 98.0
HKD2_k127_2278125_3 Sigma factor PP2C-like phosphatases - - - 0.000002046 59.0
HKD2_k127_2278859_0 Natural resistance-associated macrophage protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004904 499.0
HKD2_k127_2278859_1 - - - - 0.00000000000000877 87.0
HKD2_k127_2294759_0 Sodium:solute symporter family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000117 493.0
HKD2_k127_2294759_1 - - - - 0.0000000000000000000000005388 108.0
HKD2_k127_2297253_0 ADP-ribosylglycohydrolase K05521 - 3.2.2.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005799 483.0
HKD2_k127_2301841_0 helicase superfamily c-terminal domain K11927 - 3.6.4.13 0.000000000000000000000000000000000001081 143.0
HKD2_k127_2301841_1 GDSL-like Lipase/Acylhydrolase family - - - 0.00000000000000000000000000000001327 141.0
HKD2_k127_2301841_2 Tetratricopeptide repeat - - - 0.0002845 49.0
HKD2_k127_2304977_0 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0000000000001872 83.0
HKD2_k127_2306132_0 Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007985 292.0
HKD2_k127_2306132_1 Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000006075 203.0
HKD2_k127_2306132_2 Bacterial membrane protein, YfhO - - - 0.0001306 54.0
HKD2_k127_2315781_0 Uncharacterized protein conserved in bacteria (DUF2252) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 445.0
HKD2_k127_2320590_0 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) K02768,K08483,K11183 - 2.7.1.202,2.7.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007126 452.0
HKD2_k127_2320590_1 Mannose-6-phosphate isomerase - - - 0.000000000000000000000000000000000000000000003257 169.0
HKD2_k127_2320590_2 COG1925 Phosphotransferase system, HPr-related proteins K08485,K11189 GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006808,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071704,GO:1901564,GO:1901698 - 0.00000000000000000000971 95.0
HKD2_k127_2320590_3 nuclease K01174 - 3.1.31.1 0.00000007749 61.0
HKD2_k127_2329868_0 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00627 - 2.3.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004236 310.0
HKD2_k127_2329868_1 Glycosyl transferase 4-like domain - - - 0.00000000000000000000000000000000000000000000000000000003901 220.0
HKD2_k127_2329868_2 transferase activity, transferring glycosyl groups - - - 0.0000000000000003362 90.0
HKD2_k127_2331594_0 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 6.276e-242 754.0
HKD2_k127_2331594_1 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.00000000000000000000000000000000000000000008971 160.0
HKD2_k127_2338298_0 GGDEF domain - - - 0.0000000000000000000001422 110.0
HKD2_k127_2338298_1 helix_turn_helix, Lux Regulon - - - 0.0000000000005012 75.0
HKD2_k127_2338594_0 PFAM Rhomboid family - - - 0.000000000000000000000000000000000000000000000000000000000001589 225.0
HKD2_k127_2338594_1 dTDP-4-dehydrorhamnose reductase activity K00067,K01790,K19997 - 1.1.1.133,5.1.3.13,5.1.3.26 0.000000000000000000000000000000000000000000000003003 178.0
HKD2_k127_2338594_2 - - - - 0.0000000007819 62.0
HKD2_k127_234733_0 PFAM Peptidase S41 K03797 - 3.4.21.102 0.000000000000000000000000000000000000000000000000005868 205.0
HKD2_k127_234733_1 Peptidase family M23 K21471 - - 0.000000000000000000000000000000000000009272 150.0
HKD2_k127_234733_2 peptidase - - - 0.0003132 49.0
HKD2_k127_2357896_0 Belongs to the glyceraldehyde-3-phosphate dehydrogenase family K00134 - 1.2.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001116 480.0
HKD2_k127_2357896_1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000005608 199.0
HKD2_k127_2357896_2 Belongs to the phosphoglycerate kinase family K00927 GO:0001871,GO:0002020,GO:0003674,GO:0003824,GO:0004618,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009893,GO:0009986,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019222,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030162,GO:0030193,GO:0030195,GO:0030246,GO:0030247,GO:0030312,GO:0031323,GO:0031325,GO:0032101,GO:0032102,GO:0032268,GO:0032270,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043532,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0045862,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048518,GO:0048519,GO:0048522,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050818,GO:0050819,GO:0050878,GO:0051171,GO:0051173,GO:0051186,GO:0051188,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051917,GO:0051919,GO:0055086,GO:0060255,GO:0061041,GO:0061045,GO:0065007,GO:0065008,GO:0070613,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0080134,GO:0090407,GO:1900046,GO:1900047,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903034,GO:1903035,GO:1903317,GO:1903319,GO:2001065 2.7.2.3 0.000000000000000000000000000000001094 131.0
HKD2_k127_2369665_0 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue K02236,K02278,K02506,K02654,K10966 - 3.4.23.43 0.00000000000000000000000000000000000000000000000000000001124 209.0
HKD2_k127_2369665_1 oligosaccharyl transferase activity - - - 0.000000000000000000000000004256 118.0
HKD2_k127_2373899_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000954 368.0
HKD2_k127_2376509_0 Metallo-beta-lactamase superfamily K01069 - 3.1.2.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001223 431.0
HKD2_k127_2376509_1 Belongs to the GPAT DAPAT family K00631 - 2.3.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000001591 275.0
HKD2_k127_2383666_0 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate K03474 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000002957 308.0
HKD2_k127_2383666_1 Protein serine threonine phosphatase K20074 - 3.1.3.16 0.0000000000000000000000000000000000000000000000000000000000001592 222.0
HKD2_k127_2383666_2 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.000000000000000000000000000000000000000000000001449 178.0
HKD2_k127_2393430_0 PFAM peptidase M48 Ste24p - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007347 351.0
HKD2_k127_2393430_1 Bacterial SH3 domain - - - 0.00000000000000000000000000000000000000000000000000000000000001626 219.0
HKD2_k127_2393430_2 PFAM CHASE2 domain - - - 0.00000000000000000000000000000000001446 140.0
HKD2_k127_239985_0 - - - - 0.000000000000000000000000000000000000000000000002074 181.0
HKD2_k127_239985_1 GNaT family - - - 0.000000000000000000000000000000000000000336 151.0
HKD2_k127_239985_2 Phosphate acyltransferases K00655 - 2.3.1.51 0.00000000000000000000000000000005865 139.0
HKD2_k127_2400049_0 Protein of unknown function (DUF3309) - - - 0.00000000000000009237 88.0
HKD2_k127_2400049_2 nuclear chromosome segregation - - - 0.00002547 53.0
HKD2_k127_2403874_0 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006661 484.0
HKD2_k127_2406969_0 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003277 353.0
HKD2_k127_2409574_0 tartrate metabolic process K01676,K01678 - 4.2.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005082 407.0
HKD2_k127_2418414_0 Serine/Threonine protein kinases, catalytic domain K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000002213 233.0
HKD2_k127_2418414_1 Heat shock protein DnaJ domain protein - - - 0.000000000000000000000000000000000000000000000000000008729 203.0
HKD2_k127_2418414_2 HNH nucleases - - - 0.000000000000000000000000222 107.0
HKD2_k127_242265_0 Beta-agarase K01219 - 3.2.1.81 0.000000000000000000000000000000000000000000000000496 188.0
HKD2_k127_2434826_0 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress K04083 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000009383 271.0
HKD2_k127_2434826_1 Zinc carboxypeptidase - - - 0.000000000000000000000000000000000000000000000003186 181.0
HKD2_k127_2460802_0 Ribonuclease HII K03470 GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008592 277.0
HKD2_k127_2460802_1 - - - - 0.000000000000000000000000000000000000000000005407 166.0
HKD2_k127_246558_0 Polysulphide reductase, NrfD K00185 - - 8.387e-218 685.0
HKD2_k127_246558_1 PFAM 4Fe-4S K00184,K21308 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000809 555.0
HKD2_k127_246558_2 Protein of unknown function (DUF3341) - - - 0.00000000000000000000000000000000000000000000000000000000000000000007086 235.0
HKD2_k127_246558_3 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0000000000000000000000000000000000000000000000000000000000000000007723 243.0
HKD2_k127_2474787_0 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) K01870 - 6.1.1.5 0.0 1027.0
HKD2_k127_2474787_1 This protein specifically catalyzes the removal of signal peptides from prolipoproteins K03101 - 3.4.23.36 0.00000000000000000000000000000000000001831 154.0
HKD2_k127_2474787_2 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins K13292 - - 0.00000000000001603 76.0
HKD2_k127_2475739_0 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) K02275 - 1.9.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002712 364.0
HKD2_k127_2475739_1 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000002863 274.0
HKD2_k127_2476650_0 Glycosyltransferase like family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001899 566.0
HKD2_k127_2481305_0 Pfam:DUF955 K07110 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007406 604.0
HKD2_k127_2481305_1 Malate synthase K01638 - 2.3.3.9 0.0000000000000000000000000000000000000000000000000000000000000000000001878 244.0
HKD2_k127_2481305_2 - - - - 0.00000000000000000000000000000000000000000000000000000000001699 223.0
HKD2_k127_2485080_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000069 270.0
HKD2_k127_2487264_0 5TM C-terminal transporter carbon starvation CstA K06200 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009832 469.0
HKD2_k127_2508813_0 Possible lysine decarboxylase K06966 - 3.2.2.10 0.0000000000000000000000000000000000000000000000000000000000000008149 240.0
HKD2_k127_2508813_1 von Willebrand factor, type A - - - 0.00000000103 61.0
HKD2_k127_2508813_2 - - - - 0.0000006914 60.0
HKD2_k127_2509114_0 Large extracellular alpha-helical protein - - - 2.38e-305 948.0
HKD2_k127_2509770_0 PFAM phospholipid glycerol acyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000004181 305.0
HKD2_k127_2509770_1 PFAM Patatin - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009944 282.0
HKD2_k127_2509770_2 NAD dependent epimerase/dehydratase family K01784 - 5.1.3.2 0.00000000000000000000000000000000000000000000000000000000000000105 230.0
HKD2_k127_2515617_0 amino acid K03294,K13868 - - 0.0000000000000000000000000000000000000000000000000000000000002845 228.0
HKD2_k127_2515617_1 PFAM Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000003512 137.0
HKD2_k127_2518426_0 Zn peptidase - - - 0.000000000000000000000000000000000000000000007661 179.0
HKD2_k127_2518426_1 membrane - - - 0.0001452 49.0
HKD2_k127_2526023_0 damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage K03702,K08999 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001203 485.0
HKD2_k127_2526023_1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00058 - 1.1.1.399,1.1.1.95 0.000000000000000000002411 100.0
HKD2_k127_2526302_0 Oligopeptidase F K08602 GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004147 465.0
HKD2_k127_2526302_1 Male sterility protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002923 327.0
HKD2_k127_2526302_2 Betaine aldehyde dehydrogenase K00130 - 1.2.1.8 0.0000000000000000000000000000004487 137.0
HKD2_k127_2528075_0 lipase activity K15349 - - 0.0000000000000000004946 102.0
HKD2_k127_2531923_0 General secretory system II protein E domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003339 544.0
HKD2_k127_2536352_0 radical SAM domain protein K22318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002646 609.0
HKD2_k127_2536352_1 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006897 332.0
HKD2_k127_2536352_2 Domain in cystathionine beta-synthase and other proteins. - - - 0.0000000000000000000000000000000000473 139.0
HKD2_k127_2536352_3 Aminoacyl-tRNA editing domain K19055 - - 0.000000000000000000000000000003197 125.0
HKD2_k127_2545416_0 Pyridoxal-dependent decarboxylase conserved domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000142 253.0
HKD2_k127_2545416_1 - - - - 0.000000000000000002706 93.0
HKD2_k127_2545416_2 Sugar (and other) transporter - - - 0.0000121 57.0
HKD2_k127_255590_0 Aldehyde dehydrogenase family K02618,K15514 - 1.2.1.77,1.2.1.91,3.3.2.12 2.893e-196 625.0
HKD2_k127_255590_1 PFAM peptidase S9A prolyl oligopeptidase domain protein beta-propeller K01354 - 3.4.21.83 0.000000002386 57.0
HKD2_k127_2557030_0 Aminomethyltransferase folate-binding domain K00605 - 2.1.2.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001125 387.0
HKD2_k127_2557030_1 PFAM type II secretion system protein E K02652 - - 0.0000000000000000000000000000000000000000000000007512 197.0
HKD2_k127_2557030_2 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein K02437 - - 0.000000000000000000000000000000000000001726 165.0
HKD2_k127_2558613_0 Two component regulator propeller - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003289 393.0
HKD2_k127_2558613_1 COG2885 Outer membrane protein and related peptidoglycan-associated (lipo)proteins K03286 - - 0.000001842 59.0
HKD2_k127_2564574_0 PFAM HhH-GPD K07457 - - 0.0000000000000000000000000000000000000000000000000000000000004342 218.0
HKD2_k127_2564574_1 nuclear chromosome segregation - - - 0.000003537 58.0
HKD2_k127_2572431_0 Two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004181 460.0
HKD2_k127_2572431_1 histidine kinase A domain protein K02482 - 2.7.13.3 0.0000000001381 62.0
HKD2_k127_2584627_0 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type K11381 - 1.2.4.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005241 389.0
HKD2_k127_2584627_1 Patatin-like phospholipase K07001 - - 0.00002382 51.0
HKD2_k127_2591700_0 6-phosphofructokinase activity K00850,K00895,K21071 GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008443,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0046872,GO:0047334,GO:0071704,GO:1901135 2.7.1.11,2.7.1.90 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003962 605.0
HKD2_k127_2591700_1 Multidrug transporter - - - 0.000000000004048 69.0
HKD2_k127_261636_0 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose K01711 - 4.2.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000878 402.0
HKD2_k127_261636_1 COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains K02481,K13599 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007264 391.0
HKD2_k127_2618260_0 M3B, thimet oligopeptidase F K08602 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003388 460.0
HKD2_k127_2618634_0 Biotin carboxylase K01959,K01961 - 6.3.4.14,6.4.1.1,6.4.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003975 526.0
HKD2_k127_2618634_1 first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA K02160 - - 0.000000000000000000000000000000000000002504 153.0
HKD2_k127_2618634_2 Roadblock/LC7 domain - - - 0.00000000004749 69.0
HKD2_k127_2624198_0 - - - - 0.00000000000000000000000000000000000657 144.0
HKD2_k127_2624198_1 Outer membrane efflux protein - - - 0.000000000000000000000000000009377 134.0
HKD2_k127_2630232_0 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine K01251 GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 4.654e-244 772.0
HKD2_k127_2630232_1 Belongs to the glycosyl hydrolase 13 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000004829 264.0
HKD2_k127_2630232_2 Methyltransferase type 11 K03892 - - 0.00000000000000000000000000000000000000000000000000000000000000004205 229.0
HKD2_k127_263314_0 Domain of unknown function (DUF4388) K03413 - - 0.0000000000000000000000000002603 130.0
HKD2_k127_263314_1 cheY-homologous receiver domain - - - 0.000000000000000000002185 108.0
HKD2_k127_263314_2 Glutaredoxin K03676 - - 0.000000001481 60.0
HKD2_k127_2635691_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001113 274.0
HKD2_k127_2635691_1 Phosphoesterase, PA-phosphatase related protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003899 274.0
HKD2_k127_2648250_0 Belongs to the aldehyde dehydrogenase family K00128,K22445 - 1.2.1.3,1.2.99.10 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009355 324.0
HKD2_k127_2648250_1 Major Facilitator Superfamily - - - 0.00004621 50.0
HKD2_k127_2654349_0 HD domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003883 280.0
HKD2_k127_2654349_1 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002471 258.0
HKD2_k127_2654349_2 metal-dependent phosphohydrolase, HD sub domain K07814 - - 0.0000000000000000000000000000000000000000000000000000000000001905 235.0
HKD2_k127_2654349_3 Diguanylate cyclase - - - 0.00000000000000000000000000000000000000007411 156.0
HKD2_k127_2654349_4 cheY-homologous receiver domain K11443 - - 0.000000000000000000000000003082 118.0
HKD2_k127_2657445_0 PFAM extracellular solute-binding protein, family 5 K02035 - - 0.0000000000000000000000000000000402 136.0
HKD2_k127_2657445_1 GDSL-like Lipase/Acylhydrolase - - - 0.000000000000000008576 95.0
HKD2_k127_2662111_0 Glycosyl hydrolase 36 superfamily, catalytic domain K00702,K13688 - 2.4.1.20 0.0 1060.0
HKD2_k127_2672393_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002466 559.0
HKD2_k127_2672393_1 4Fe-4S binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009389 340.0
HKD2_k127_2672393_2 Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit - - - 0.0000000000000000000002067 100.0
HKD2_k127_2672393_3 - - - - 0.00001392 57.0
HKD2_k127_2678180_0 integral membrane protein - - - 0.000000000000000000000000000000000000000000000000000000007285 209.0
HKD2_k127_2678180_1 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000000002287 194.0
HKD2_k127_2696332_0 Cytochrome b subunit of the bc complex K00412 - - 1.628e-223 703.0
HKD2_k127_2696332_1 PFAM Rieske 2Fe-2S domain K03886 - - 0.0003341 44.0
HKD2_k127_2710879_0 Protein of unknown function, DUF255 K06888 - - 3.14e-210 666.0
HKD2_k127_2710879_1 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000005072 263.0
HKD2_k127_2710879_2 Serine aminopeptidase, S33 - - - 0.0000000000000000000000000000002653 130.0
HKD2_k127_2714959_0 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) K11785 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001761 342.0
HKD2_k127_2714959_1 - - - - 0.0000191 54.0
HKD2_k127_2714959_2 COG0526 Thiol-disulfide isomerase and thioredoxins - - - 0.00003399 52.0
HKD2_k127_2718464_0 PFAM EAL domain - - - 0.00000000000000000000000000000000000000000000000000000000002687 228.0
HKD2_k127_2718464_1 PFAM EAL domain protein - - - 0.000000000000000000000000000000000000000000007083 171.0
HKD2_k127_2718464_2 PFAM GGDEF domain containing protein - - - 0.00000000000000000000000000005278 127.0
HKD2_k127_2718464_3 PFAM response regulator receiver K07657 - - 0.0000000000000000000000000005699 118.0
HKD2_k127_2721803_0 Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation K07082 - - 0.0000000000000000000000000000000000000000000000000000000000000000003113 243.0
HKD2_k127_2721803_1 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000002545 192.0
HKD2_k127_2721803_2 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA K07447 - - 0.000000000000000000000000000000000000001565 154.0
HKD2_k127_2721803_3 extracellular matrix structural constituent - - - 0.0000000234 66.0
HKD2_k127_2735783_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007429 307.0
HKD2_k127_2735783_1 response to abiotic stimulus K06867 - - 0.00001529 52.0
HKD2_k127_2739976_0 Voltage gated chloride channel K03281 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004106 548.0
HKD2_k127_2739976_1 - - - - 0.0000000000000000000000000000785 120.0
HKD2_k127_2744319_0 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone K03168 - 5.99.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001642 620.0
HKD2_k127_2744319_1 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs K04094 - 2.1.1.74 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002994 526.0
HKD2_k127_2744319_2 Phage integrase, N-terminal SAM-like domain K03733,K04763 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000005104 297.0
HKD2_k127_2753533_0 Alpha-2-Macroglobulin K06894 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003291 350.0
HKD2_k127_2758948_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001538 284.0
HKD2_k127_2758948_1 PFAM MscS Mechanosensitive ion channel K16052 - - 0.0000000000000000000000000000000000001252 149.0
HKD2_k127_2758948_2 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.00000000000000001636 88.0
HKD2_k127_2758948_3 regulator of chromosome condensation, RCC1 - - - 0.000000002946 59.0
HKD2_k127_2760206_0 Elongation factor G, domain IV K02355 - - 2.192e-205 665.0
HKD2_k127_2760206_1 Pilus assembly protein K02662 - - 0.000001136 59.0
HKD2_k127_2767648_1 Spermidine synthase K00797 - 2.5.1.16 0.0000000000004801 72.0
HKD2_k127_2769993_0 Glutamine amidotransferases class-II K00764 - 2.4.2.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001665 593.0
HKD2_k127_2769993_1 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 0.0000000002799 64.0
HKD2_k127_2769993_2 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - 0.000000008757 61.0
HKD2_k127_2771919_0 - K16923 - - 0.0000000000000000000000000000000000000000000000000000000000002387 233.0
HKD2_k127_2771919_1 NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form - - - 0.000000000000000000000000000000000000000001387 159.0
HKD2_k127_2775276_0 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane K03070 GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005722 384.0
HKD2_k127_2775276_1 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001392 302.0
HKD2_k127_2777246_0 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs K03177 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481 5.4.99.25 0.00000000000000000000000000000000000000000000000000000000000002909 225.0
HKD2_k127_2777246_1 chaperone-mediated protein folding - - - 0.0000000000000000000000000000000000000000000001384 190.0
HKD2_k127_2777246_2 Protein of unknown function (DUF502) - GO:0003002,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0007275,GO:0007389,GO:0008150,GO:0010051,GO:0010222,GO:0012505,GO:0016020,GO:0016021,GO:0031224,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0048856 - 0.000000000000000000000000008102 125.0
HKD2_k127_2777246_3 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA K02834 - - 0.0000000000000000000000508 104.0
HKD2_k127_2777246_4 cAMP biosynthetic process - - - 0.0002881 46.0
HKD2_k127_2783925_0 Ras family - - - 0.0000000000000000000000000000000000000000000000000006059 201.0
HKD2_k127_2783925_1 Belongs to the bacterial ribosomal protein bL28 family K02902 - - 0.0000000000000000001501 93.0
HKD2_k127_27967_0 Protein tyrosine kinase K08282,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000004631 282.0
HKD2_k127_2797671_0 Formate dehydrogenase, alpha subunit K00123 - 1.17.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002638 596.0
HKD2_k127_2797671_1 'glutamate synthase - - - 0.000004554 52.0
HKD2_k127_2798328_0 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002487 280.0
HKD2_k127_2798328_1 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.0000000000000000000000000000000000001067 141.0
HKD2_k127_2799904_0 Belongs to the LarC family K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003451 339.0
HKD2_k127_2799904_1 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation K01874 GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 0.000000000000000000000000000000000000000000003155 183.0
HKD2_k127_2818365_0 Mate efflux family protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 361.0
HKD2_k127_2818365_1 Major Facilitator Superfamily - - - 0.00000000000000000000000000000000000000000002217 173.0
HKD2_k127_2838375_0 FeS assembly protein SufB K07033,K09014 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - 1.99e-225 704.0
HKD2_k127_2838375_1 COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component K09014 - - 0.00000000000000000000000003651 107.0
HKD2_k127_2838375_2 ABC transporter K09013 - - 0.00000000000000000000000005608 110.0
HKD2_k127_2850768_0 Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) K00099 GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 426.0
HKD2_k127_2850768_1 Peptidase family M50 K11749 - - 0.0000000000000000000000000000000000000005434 153.0
HKD2_k127_2850768_2 Belongs to the CDS family K00981 - 2.7.7.41 0.0000000000000000000000000000000000001641 145.0
HKD2_k127_2860504_0 tRNA synthetases class II (D, K and N) K04567 - 6.1.1.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001141 536.0
HKD2_k127_2860504_1 MacB-like periplasmic core domain K09808 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004117 361.0
HKD2_k127_2860504_2 Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner K09810 - - 0.000000000000000000000000000000000000001394 166.0
HKD2_k127_2866292_0 Belongs to the heat shock protein 70 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001477 538.0
HKD2_k127_2873481_0 pfkB family carbohydrate kinase K03272 - 2.7.1.167,2.7.7.70 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003106 297.0
HKD2_k127_2873481_1 D,d-heptose 1,7-bisphosphate phosphatase K03273 - 3.1.3.82,3.1.3.83 0.000000000000000000000000000000000000000000000000001155 198.0
HKD2_k127_2873481_2 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose - - - 0.0000000000000000000000000000000000000000000003413 188.0
HKD2_k127_2873481_3 Glycosyltransferase family 9 (heptosyltransferase) K02843 - - 0.000000000000000000000000000000000000000000003728 171.0
HKD2_k127_2873481_4 PFAM glycosyl transferase family 9 K02841 - - 0.000000000002505 77.0
HKD2_k127_2889573_0 serine threonine protein kinase K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000003557 227.0
HKD2_k127_2917447_0 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000001626 132.0
HKD2_k127_2921620_0 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002558 303.0
HKD2_k127_2921620_1 Oxidoreductase NAD-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003541 285.0
HKD2_k127_2921620_2 Belongs to the NiFe NiFeSe hydrogenase large subunit family K14126,K17993 GO:0003674,GO:0005488,GO:0005575,GO:0016151,GO:0032991,GO:0043167,GO:0043169,GO:0044569,GO:0046872,GO:0046914,GO:1902494 1.12.1.3,1.12.1.5,1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000002876 248.0
HKD2_k127_2921620_3 NADH ubiquinone oxidoreductase, 20 Kd subunit K18007 - 1.12.1.2 0.0000000000000000000000000000000000000000000000000000006426 215.0
HKD2_k127_2930719_0 Belongs to the sigma-70 factor family. ECF subfamily - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001436 394.0
HKD2_k127_2930719_1 protein conserved in bacteria - - - 0.00000000000000000000000000000000000000000000001265 186.0
HKD2_k127_2930719_2 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000006417 177.0
HKD2_k127_2946329_0 Leukotriene A4 hydrolase, C-terminal K01254 GO:0003674,GO:0003824,GO:0004177,GO:0004301,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016787,GO:0016801,GO:0016803,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.3.2.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006925 482.0
HKD2_k127_2946329_1 OPT oligopeptide transporter protein - - - 0.0000000000000000000000000000000000000000000000000000000003416 209.0
HKD2_k127_2956300_0 ResB-like family - - - 0.0000000000000000000001166 110.0
HKD2_k127_2956300_1 Forkhead associated domain - - - 0.00000000000000001218 88.0
HKD2_k127_2957733_0 Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane K03980 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001855 517.0
HKD2_k127_2957733_1 Aldo Keto reductase - - - 0.0000168 47.0
HKD2_k127_2958632_0 Beta-eliminating lyase K01668 - 4.1.99.2 0.0000000000000000000000000000000000000000000000000000000000009576 223.0
HKD2_k127_2958632_1 helix_turn_helix ASNC type K03719 - - 0.0000000000000000000000000000000000000000007078 163.0
HKD2_k127_2958632_2 epimerase - - - 0.00003723 46.0
HKD2_k127_295952_0 Cytochrome c7 and related cytochrome c K19405,K19411 GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 2.7.14.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001507 281.0
HKD2_k127_295952_1 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000001803 252.0
HKD2_k127_2959813_0 NAD-dependent epimerase dehydratase K00091 - 1.1.1.219 0.0000000000000000000000000000000000000000000000000000000000000000007988 234.0
HKD2_k127_2959813_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000003052 79.0
HKD2_k127_2965982_0 GDSL-like Lipase/Acylhydrolase family - - - 0.000000000000000001572 99.0
HKD2_k127_2972097_0 two component, sigma54 specific, transcriptional regulator, Fis family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000102 503.0
HKD2_k127_2972097_1 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001331 329.0
HKD2_k127_2976356_0 FabA-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004716 609.0
HKD2_k127_2980839_0 Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force K15987 - 3.6.1.1 1.284e-255 814.0
HKD2_k127_2980839_1 PGAP1-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005305 396.0
HKD2_k127_2980839_2 DNA helicase K03657 - 3.6.4.12 0.000004196 52.0
HKD2_k127_2998649_0 Thioredoxin-like [2Fe-2S] ferredoxin K00334 - 1.6.5.3 0.000000000000000000000000000000000000002264 162.0
HKD2_k127_2998649_1 Iron only hydrogenase large subunit, C-terminal domain - - - 0.0000000000000000000000000003777 120.0
HKD2_k127_2998649_2 Fe-S cluster domain protein - - - 0.00000000000000000001939 104.0
HKD2_k127_3004212_0 Tetratricopeptide repeat - - - 0.000000000000003096 88.0
HKD2_k127_3016081_0 Mur ligase, middle domain K11754 - 6.3.2.12,6.3.2.17 0.00000000000000000000000000000000000000000000005446 187.0
HKD2_k127_3016081_1 Belongs to the MraZ family K03925 GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - 0.00000000000000000000000000000006508 130.0
HKD2_k127_3018026_0 COG4771 Outer membrane receptor for ferrienterochelin and colicins K02014 - - 0.000000000000000000000000000000000000000000000000000000000000000004875 252.0
HKD2_k127_3018026_1 Two component regulator propeller - - - 0.000000000000000000000000000000001396 145.0
HKD2_k127_301924_0 Acetyl-CoA hydrolase/transferase N-terminal domain K01067 - 3.1.2.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009434 553.0
HKD2_k127_301924_1 spore germination - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002052 376.0
HKD2_k127_301924_2 Bacterial regulatory proteins, tetR family - - - 0.000000000000004136 79.0
HKD2_k127_3023322_0 Peptidase family M28 - - - 0.0000000000000000000000000000000000000000000000000000000000000000007891 248.0
HKD2_k127_3032740_0 TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit K00239 - 1.3.5.1,1.3.5.4 0.0 1030.0
HKD2_k127_3032740_1 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001443 409.0
HKD2_k127_3032740_2 - K00241 - - 0.00000000000000000000000000000000000000000000000000000000000000000001262 240.0
HKD2_k127_3033375_0 NAD(P)-binding Rossmann-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006931 436.0
HKD2_k127_3033375_1 - - - - 0.0000000000000003206 92.0
HKD2_k127_3049087_0 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005067 520.0
HKD2_k127_3049087_1 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS K01881 - 6.1.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001349 433.0
HKD2_k127_3054199_0 Sulfatase - - - 0.000000000000000000000000000000000000000001404 168.0
HKD2_k127_3063043_0 PFAM Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006128 384.0
HKD2_k127_3063043_1 KR domain - - - 0.0000000000000000000000000000000000000000000001088 176.0
HKD2_k127_3068718_0 Transketolase, pyrimidine binding domain K11381 - 1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008947 494.0
HKD2_k127_3068718_1 Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) K02433 - 6.3.5.6,6.3.5.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002496 423.0
HKD2_k127_3068718_2 LysR substrate binding domain - - - 0.0000000000000000000000000000002724 140.0
HKD2_k127_3068718_3 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - 0.0000000000000000001784 96.0
HKD2_k127_3068718_4 Pfam Adenylate and Guanylate cyclase catalytic domain K01768,K07315 - 3.1.3.3,4.6.1.1 0.000000003148 62.0
HKD2_k127_3090420_0 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity K02886 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004861 407.0
HKD2_k127_3090420_1 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation K02982 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001325 324.0
HKD2_k127_3090420_10 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit K02895 - - 0.000000000000000000000000000000006312 131.0
HKD2_k127_3090420_11 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome K02890 - - 0.0000000000000000000000000001032 120.0
HKD2_k127_3090420_12 One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome K02892 - - 0.0000000000000000000000000004343 119.0
HKD2_k127_3090420_13 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA K02961 - - 0.000000000000000000000001805 106.0
HKD2_k127_3090420_14 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site K02954 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000007668 102.0
HKD2_k127_3090420_15 Forms part of the polypeptide exit tunnel K02926 - - 0.0000000001154 64.0
HKD2_k127_3090420_16 Ribosomal L29 protein K02904 - - 0.000000004256 66.0
HKD2_k127_3090420_2 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits K02931 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000005156 253.0
HKD2_k127_3090420_3 Ribosomal protein L16p/L10e K02878 - - 0.0000000000000000000000000000000000000000000000000000000000000002626 222.0
HKD2_k127_3090420_4 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome K02874 - - 0.0000000000000000000000000000000000000000000000000000001019 196.0
HKD2_k127_3090420_5 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center K02933 - - 0.0000000000000000000000000000000000000000000000000000003257 205.0
HKD2_k127_3090420_6 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit K02994 - - 0.000000000000000000000000000000000000000000000000000104 189.0
HKD2_k127_3090420_7 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000000000001739 159.0
HKD2_k127_3090420_8 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance K02881 - - 0.0000000000000000000000000000000000000007883 152.0
HKD2_k127_3090420_9 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA K02965 - - 0.00000000000000000000000000000000001298 149.0
HKD2_k127_3109166_0 PFAM Thioredoxin domain K03671 - - 0.000000000000000000000000000000000005038 139.0
HKD2_k127_3109166_1 - - - - 0.000000000000000000207 91.0
HKD2_k127_3109166_3 MacB-like periplasmic core domain K02004 - - 0.000000000000002472 75.0
HKD2_k127_3109166_4 COGs COG4773 Outer membrane receptor for ferric coprogen and ferric-rhodotorulic acid K02014 - - 0.00000002417 62.0
HKD2_k127_3119946_0 Elongator protein 3, MiaB family, Radical SAM - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003188 349.0
HKD2_k127_3123777_0 Belongs to the peptidase S1C family K04771 - 3.4.21.107 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001817 367.0
HKD2_k127_3123777_1 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.0000000000000000000000000000000000000000000000000000000000000000000003565 249.0
HKD2_k127_3123777_2 Prokaryotic dksA/traR C4-type zinc finger K06204 - - 0.00000000000005355 79.0
HKD2_k127_3135325_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003911 437.0
HKD2_k127_3138260_0 Sigma-70, region 4 K03088 - - 0.00000000000000000000000000000008765 132.0
HKD2_k127_3138260_1 HD domain - - - 0.000000000000000000000000000006561 126.0
HKD2_k127_3138260_2 Belongs to the anti-sigma-factor antagonist family K04749 - - 0.0000000000000000000000196 104.0
HKD2_k127_3161527_0 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine K01586 - 4.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009551 349.0
HKD2_k127_3161527_1 ABC transporter substrate-binding protein K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000002026 260.0
HKD2_k127_3161527_2 Protein of unknown function (DUF819) - - - 0.0000000000000000000000000000000000001036 149.0
HKD2_k127_3170147_0 RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication K02316 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000006556 316.0
HKD2_k127_3170147_1 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.000000000000000000000000000000000002225 151.0
HKD2_k127_3176252_0 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 7.413e-204 646.0
HKD2_k127_3176252_1 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01667 - 4.1.99.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002563 510.0
HKD2_k127_3178331_0 FabA-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007031 428.0
HKD2_k127_3192411_0 spore germination - - - 0.00000000000000000000000000000000000000000000000000000000000000000000008012 256.0
HKD2_k127_3192411_1 PFAM glycosyl transferase family 9 K02841 - - 0.0000000000000000000000000000000000002458 149.0
HKD2_k127_3192411_2 Phospholipid methyltransferase - - - 0.00000000000000000000000002324 115.0
HKD2_k127_3195130_0 transferase K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000000000000000000005596 182.0
HKD2_k127_3195130_1 Catalyzes a key regulatory step in fatty acid biosynthesis K10780 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.104 0.0000000000000000000000000000000406 128.0
HKD2_k127_3203669_0 zinc metallopeptidase K07054 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008243 365.0
HKD2_k127_3203669_1 Type II/IV secretion system protein - - - 0.0000000000000000000000000000000000000000000003981 174.0
HKD2_k127_3203669_2 competence protein - - - 0.0000000003755 63.0
HKD2_k127_3229323_0 Enoyl-CoA hydratase/isomerase K01715 - 4.2.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003357 307.0
HKD2_k127_3229323_1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.000000000000000000000000000000000000000009129 154.0
HKD2_k127_3229323_2 Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin K00794 - 2.5.1.78 0.0000000000000000000001653 102.0
HKD2_k127_3249650_0 A domain family that is part of the cupin metalloenzyme superfamily. K18850 - 1.14.11.47 0.000000000000000000000000000000000000000000000000000000000002319 219.0
HKD2_k127_3249650_1 Responsible for synthesis of pseudouridine from uracil K06179,K06180 - 5.4.99.23,5.4.99.24 0.00000000000000000000000000000000000005009 151.0
HKD2_k127_3253712_0 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000000000000000000000000000002005 228.0
HKD2_k127_3253712_1 Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway K16148 - 2.4.1.342 0.00007774 45.0
HKD2_k127_3281788_0 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000153 368.0
HKD2_k127_3281788_1 Belongs to the UPF0312 family - - - 0.00000000000000000000000000000000000000000000000000000000000000002057 228.0
HKD2_k127_3281788_2 helix_turn_helix multiple antibiotic resistance protein - - - 0.000000000000000000002883 95.0
HKD2_k127_3283578_0 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor K00281,K00283 - 1.4.4.2 3.931e-245 764.0
HKD2_k127_3283578_1 Acyl- acyl-carrier-protein --UDP-N-acetylglucosamine O-acyltransferase K00677 - 2.3.1.129 0.0000000000000000000000000000000000000000000000000000000000000000000000002613 255.0
HKD2_k127_3286847_0 Efflux ABC transporter permease protein K02004 - - 0.00000000000000000000000000000000000000000000000000000000001888 223.0
HKD2_k127_3286847_1 Efflux ABC transporter permease protein K02004 - - 0.000000000000000000000000000000000001507 159.0
HKD2_k127_3286847_2 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000001984 76.0
HKD2_k127_3287161_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K00266 - 1.4.1.13,1.4.1.14 0.0 1130.0
HKD2_k127_3289866_0 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003873 315.0
HKD2_k127_3289866_1 PFAM flavin reductase domain protein, FMN-binding K14631 - - 0.0000000000000000000000000000000000000202 149.0
HKD2_k127_3289866_2 - - - - 0.00001006 55.0
HKD2_k127_3337190_0 chitin binding - - - 0.000000000000000000000000000000001276 147.0
HKD2_k127_3337190_1 Belongs to the multicopper oxidase YfiH RL5 family K05810 - - 0.000000000000000000000000007299 116.0
HKD2_k127_3337896_0 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001945 450.0
HKD2_k127_3337896_1 Protein involved in outer membrane biogenesis - - - 0.00000000000308 77.0
HKD2_k127_3344133_0 uridine kinase K00876 - 2.7.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001675 509.0
HKD2_k127_3344133_1 protein kinase activity K12132 - 2.7.11.1 0.0000000105 66.0
HKD2_k127_3345425_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 311.0
HKD2_k127_3345425_1 COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases K21564 - - 0.000000001555 66.0
HKD2_k127_3346624_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007137 515.0
HKD2_k127_3351107_0 Inner membrane component of T3SS, cytoplasmic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000002739 278.0
HKD2_k127_3353108_0 Dehydrogenase K15371 GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 1.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008721 341.0
HKD2_k127_3354042_0 Histidine kinase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000009508 262.0
HKD2_k127_335565_0 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) K01876 - 6.1.1.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001961 616.0
HKD2_k127_3356249_0 Penicillin amidase K01434,K07116 - 3.5.1.11,3.5.1.97 0.00000000000000000000000000000000000000000000000000000000005965 214.0
HKD2_k127_3356249_1 NmrA-like family - - - 0.000000000000000000000000000000000000000000000000000408 205.0
HKD2_k127_3360411_0 aminotransferase class V - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001381 347.0
HKD2_k127_3360411_1 D-isomer specific 2-hydroxyacid dehydrogenase K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000001832 207.0
HKD2_k127_3360411_2 Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins K04487 - 2.8.1.7 0.00000005735 55.0
HKD2_k127_3362169_0 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system K02045 - 3.6.3.25 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002227 451.0
HKD2_k127_3362169_1 Binding-protein-dependent transport system inner membrane component K02047 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007163 340.0
HKD2_k127_3362169_2 Binding-protein-dependent transport system inner membrane component K02046 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001189 332.0
HKD2_k127_3367824_0 ABC transporter substrate-binding protein K02035,K13889 - - 0.000000000000000000000000000000000002807 150.0
HKD2_k127_3367824_1 Methyltransferase domain - - - 0.000000000000000000000002351 109.0
HKD2_k127_3368661_0 Sulfite exporter TauE/SafE K07090 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001087 365.0
HKD2_k127_3368661_1 Sulfate permease family K03321 - - 0.00000000000000000000000000002467 120.0
HKD2_k127_3368661_2 membrane - - - 0.0000000000000000000000002052 122.0
HKD2_k127_3368661_3 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) K03594,K04035 - 1.14.13.81,1.16.3.1 0.000000000562 63.0
HKD2_k127_3372694_0 carbamoyl transferase, NodU family K00612 - - 2.784e-212 675.0
HKD2_k127_3372694_1 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA K01962,K01963 - 2.1.3.15,6.4.1.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002568 344.0
HKD2_k127_3375615_0 Aminotransferase class-V K11717 - 2.8.1.7,4.4.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 557.0
HKD2_k127_3375615_1 FeS assembly protein SufD K07033,K09015 GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003687 341.0
HKD2_k127_3375615_2 TIGRFAM FeS assembly SUF system protein SufT - - - 0.0000000000000000000000000000000000000000000000000000000463 200.0
HKD2_k127_3375615_3 SUF system FeS assembly protein, NifU family K04488 - - 0.000000000000000000000000000000000000000000000000001377 206.0
HKD2_k127_3375615_4 Transcriptional regulator - - - 0.00000000000000000000000000000000000001084 164.0
HKD2_k127_3375615_5 Tautomerase enzyme - - - 0.00007865 48.0
HKD2_k127_3376620_0 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay K12574 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002294 465.0
HKD2_k127_3376620_1 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 0.0000000007156 62.0
HKD2_k127_3376620_2 COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins K03466 - - 0.000001659 61.0
HKD2_k127_3376887_0 Peptidase family S49 K04773 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009057 349.0
HKD2_k127_3376887_1 Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - 0.0000000005807 66.0
HKD2_k127_3377921_0 Acetyltransferase (GNAT) domain - - - 0.0000000000000000000000000000000000000001541 163.0
HKD2_k127_3377921_1 Tetratricopeptide repeat - - - 0.0000000000001582 78.0
HKD2_k127_3378607_0 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 1.372e-296 922.0
HKD2_k127_3378607_1 PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001112 501.0
HKD2_k127_3378607_2 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001293 357.0
HKD2_k127_3378607_3 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000002023 174.0
HKD2_k127_3388293_0 CoA enzyme activase uncharacterised domain (DUF2229) - - - 4.51e-291 915.0
HKD2_k127_3391765_0 arylsulfatase activity - - - 0.0000000000000000000000000000000000006309 161.0
HKD2_k127_339604_0 Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA K00639,K00652 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000263 550.0
HKD2_k127_339604_1 CDP-alcohol phosphatidyltransferase - - - 0.0000000000000000000000000000000000000000000000000000000009783 208.0
HKD2_k127_339604_2 - K18475 - - 0.000000000000007302 86.0
HKD2_k127_339604_3 Phospholipid methyltransferase - - - 0.00000000000003579 85.0
HKD2_k127_339604_4 Anti-sigma factor - - - 0.0000166 49.0
HKD2_k127_3400844_0 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00342 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001351 548.0
HKD2_k127_3400844_1 it plays a direct role in the translocation of protons across the membrane K02108 - - 0.00000000000000000000000000000000000000000000000000000002379 212.0
HKD2_k127_3400844_2 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02109 - - 0.000000000000000000001316 104.0
HKD2_k127_3400844_3 ATP hydrolysis coupled proton transport K02110,K02124 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000009778 94.0
HKD2_k127_3400844_4 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L K00341 - 1.6.5.3 0.0000000000299 68.0
HKD2_k127_3405424_0 Belongs to the aspartokinase family K00928 - 2.7.2.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006387 436.0
HKD2_k127_3405424_1 Major Facilitator Superfamily K08218 - - 0.000000000000000000000000000000000000000000000000000000000000000000000001209 265.0
HKD2_k127_3405424_2 Response regulator receiver K07714,K07715 - - 0.0002323 46.0
HKD2_k127_3412314_0 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001147 282.0
HKD2_k127_3412314_1 deoxyhypusine monooxygenase activity - - - 0.000003454 57.0
HKD2_k127_3414870_0 Belongs to the glycosyl hydrolase 18 family - - - 0.0000000000000000000000000000000000000000000005474 184.0
HKD2_k127_3417171_0 PFAM Cys Met metabolism PLP-dependent enzyme K01739 - 2.5.1.48 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007702 417.0
HKD2_k127_3417171_1 hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - 0.00000000000000000000002387 102.0
HKD2_k127_3417171_2 Cyclic nucleotide-monophosphate binding domain - - - 0.000000000002051 77.0
HKD2_k127_3423620_0 Belongs to the beta-ketoacyl-ACP synthases family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002589 561.0
HKD2_k127_3423620_1 AIR synthase related protein, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001437 310.0
HKD2_k127_3423620_2 Heat shock 70 kDa protein - - - 0.00000214 54.0
HKD2_k127_3434226_0 Sulfatase - - - 0.00000000000000000000000000000000000000003499 171.0
HKD2_k127_3434226_1 Penicillin binding protein transpeptidase domain - - - 0.00000000000000000000000000000000000958 139.0
HKD2_k127_3443527_0 Disulphide bond corrector protein DsbC K04084 - 1.8.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007067 596.0
HKD2_k127_3443527_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 0.000000000000000000000000000000000000000000000000000000000000005937 223.0
HKD2_k127_3462971_0 SMART PAS domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000003224 242.0
HKD2_k127_3475614_0 ATP-dependent DNA helicase activity K01144,K07464,K16898 - 3.1.11.5,3.1.12.1,3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000001011 286.0
HKD2_k127_3484309_0 S1 P1 nuclease - - - 0.0000000000000000000000000000000000002487 160.0
HKD2_k127_3484309_1 protein transport across the cell outer membrane K02452,K02463 - - 0.0000000001685 68.0
HKD2_k127_3488686_0 Histidine kinase K13598 - 2.7.13.3 0.0000000000000000000000000000000005814 150.0
HKD2_k127_3488686_1 Polysaccharide lyase family 4, domain II - - - 0.00000000000823 67.0
HKD2_k127_3498091_0 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 2.156e-209 664.0
HKD2_k127_3498091_1 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 - - 0.00000000000000000000000000000000000000000000000000000005357 199.0
HKD2_k127_3520645_0 Chemotaxis sensory transducer K03406 - - 0.0000000000000000004992 102.0
HKD2_k127_3523589_0 Belongs to the UDP-glucose GDP-mannose dehydrogenase family K00012 - 1.1.1.22 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002432 539.0
HKD2_k127_3523589_1 Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation K06147,K11085 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 517.0
HKD2_k127_3523589_2 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine K13038 - 4.1.1.36,6.3.2.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000176 310.0
HKD2_k127_3523589_3 PFAM Glycosyl transferase family 2 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001083 261.0
HKD2_k127_3523589_4 Essential for recycling GMP and indirectly, cGMP K00942 GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 0.0000000000000000000000000000000000000000000000000000007395 199.0
HKD2_k127_3523589_5 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000004023 201.0
HKD2_k127_3523589_6 Domain of unknown function (DUF1732) - - - 0.000000000000000000000000000000000000000000001681 179.0
HKD2_k127_3523589_7 Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits K03060 - 2.7.7.6 0.0000339 55.0
HKD2_k127_3559076_0 PIN domain K07175 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000139 370.0
HKD2_k127_3559076_1 Belongs to the acetyltransferase family. ArgA subfamily - - - 0.000000000000000000000000000000000000000000000002088 183.0
HKD2_k127_3559076_2 acyl-coa-binding protein - - - 0.000000000000001614 76.0
HKD2_k127_3593916_0 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP K01939 GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009749 288.0
HKD2_k127_3593916_1 Histidine kinase A domain protein - - - 0.00000000000000000000000000000000001172 146.0
HKD2_k127_3604459_0 Belongs to the peptidase M16 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001364 434.0
HKD2_k127_3604459_1 Metallo-beta-lactamase superfamily - - - 0.00000000000000000000000000000000000000000000000005135 188.0
HKD2_k127_3608_0 aminopeptidase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004195 326.0
HKD2_k127_3608_1 RDD family - - - 0.00000000000000000003869 98.0
HKD2_k127_3608818_0 FAD dependent oxidoreductase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002938 422.0
HKD2_k127_3608818_1 TonB dependent receptor - - - 0.0000000005797 60.0
HKD2_k127_3618100_0 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000001172 261.0
HKD2_k127_3618100_1 Peptidase, M16 - - - 0.000000000002177 68.0
HKD2_k127_3627139_0 2-Nitropropane dioxygenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008538 542.0
HKD2_k127_3627139_1 transcriptional regulator - - - 0.0000000000000000000000000004166 121.0
HKD2_k127_363283_0 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit K02500 GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001386 261.0
HKD2_k127_363283_1 Histidine biosynthesis bifunctional protein HisIE K11755 - 3.5.4.19,3.6.1.31 0.0000000000000000000000000000000000000000000000000001547 201.0
HKD2_k127_363283_2 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia K01657 GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 0.000000000003288 79.0
HKD2_k127_365000_0 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily K02015 - - 0.000000000000000000000000000000000000000000000000000000000000004217 231.0
HKD2_k127_365000_1 ABC transporter, ATP-binding protein K02013 - 3.6.3.34 0.0000000000000000000000000000000008461 149.0
HKD2_k127_365000_2 ABC-type Fe3 -hydroxamate transport system, periplasmic component K02016 - - 0.0000008514 52.0
HKD2_k127_3651255_0 ABC transporter K01990 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001025 325.0
HKD2_k127_3651255_1 Outer membrane efflux protein - - - 0.0000000000000000000000000002513 129.0
HKD2_k127_365522_0 Enoyl-CoA hydratase/isomerase K01715,K07537 - 4.2.1.100,4.2.1.17 0.00000000000000000000000000000000000000000000000000000000002713 217.0
HKD2_k127_365522_1 Belongs to the thiolase family K00626,K00632 - 2.3.1.16,2.3.1.9 0.000000000000000000000000000000000000000000000000000000005626 202.0
HKD2_k127_365522_2 - - - - 0.0002533 49.0
HKD2_k127_3680582_0 Esterase of the alpha-beta hydrolase superfamily - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000319 436.0
HKD2_k127_3680582_1 Protein kinase domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006897 332.0
HKD2_k127_3682377_0 virulence factor MVIN family protein K03980 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005429 306.0
HKD2_k127_3683761_0 The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis K01056 - 3.1.1.29 0.0000000000000000000000000000000000000000000003444 172.0
HKD2_k127_3683761_1 Ribosomal protein S18 K02963 - - 0.000000000000000000000000031 111.0
HKD2_k127_3683761_2 Binds together with S18 to 16S ribosomal RNA K02990 - - 0.000000000000000000000006598 106.0
HKD2_k127_3687586_0 Iron-sulfur cluster-binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000006925 249.0
HKD2_k127_3687586_1 Glycosyl Transferase - - - 0.00000000001159 78.0
HKD2_k127_3687586_2 - - - - 0.0006143 51.0
HKD2_k127_3688636_0 Belongs to the SOS response-associated peptidase family - - - 0.0000000000000000000000000000000000000000000000000001848 192.0
HKD2_k127_3688636_1 Domain in cystathionine beta-synthase and other proteins. K04767 - - 0.000000000000000000002185 103.0
HKD2_k127_3688636_2 Cellulose synthase operon protein C C-terminus (BCSC_C) K20543 - - 0.0007388 49.0
HKD2_k127_3698472_0 WYL domain K13572 - - 0.0000000000000000000000000000000000000000000000000000000003753 216.0
HKD2_k127_3698472_1 - - - - 0.000000002709 63.0
HKD2_k127_3700665_0 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005203 567.0
HKD2_k127_3705850_0 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family K03215 - 2.1.1.190 0.000000000000000000000000000000000000000000000000000000000008044 225.0
HKD2_k127_3707548_0 Catalyzes the reversible hydration of fumarate to (S)- malate K01676 - 4.2.1.2 9.508e-267 832.0
HKD2_k127_3710307_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 0.0 1296.0
HKD2_k127_3710307_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002998 250.0
HKD2_k127_3710307_2 SMART DNA-directed DNA polymerase B K02336 - 2.7.7.7 0.000000000000000000000000000000000000000002223 162.0
HKD2_k127_3710455_0 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001833 461.0
HKD2_k127_3710455_1 polyketide synthase - - - 0.0000000000003456 82.0
HKD2_k127_3710455_2 histidine kinase A domain protein K02482 - 2.7.13.3 0.00006235 51.0
HKD2_k127_3712096_0 PFAM Peptidase M23 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000002492 250.0
HKD2_k127_3712096_1 Belongs to the UbiD family K03182,K16239 - 4.1.1.61,4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000001481 227.0
HKD2_k127_3714376_0 Bacterial protein of unknown function (DUF885) - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002444 456.0
HKD2_k127_37180_0 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005864 417.0
HKD2_k127_37180_1 Beta-eliminating lyase K01667,K01668 - 4.1.99.1,4.1.99.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002865 276.0
HKD2_k127_37180_2 Uncharacterized conserved protein (COG2071) K09166 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007807 263.0
HKD2_k127_37180_3 Tetratricopeptide repeat - - - 0.00000000000000000000000000000002209 142.0
HKD2_k127_371983_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 GO:0003674,GO:0003824,GO:0004766,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0010487,GO:0016740,GO:0016765,GO:0034641,GO:0042401,GO:0043918,GO:0043919,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0050314,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000013 308.0
HKD2_k127_3724542_0 DNA polymerase LigD polymerase domain K01971 - 6.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008832 416.0
HKD2_k127_3724542_1 Belongs to the NAD(P)-dependent epimerase dehydratase family K01784 - 5.1.3.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001152 352.0
HKD2_k127_3738000_0 DNA-directed DNA polymerase K02337 - 2.7.7.7 1.801e-215 684.0
HKD2_k127_3738000_1 Arginase family K01480 - 3.5.3.11 0.00000000000000001233 87.0
HKD2_k127_3756573_0 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus K00604 - 2.1.2.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000009967 265.0
HKD2_k127_3756573_1 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.0000000000000000000000000000000000000000000000000006241 188.0
HKD2_k127_3756573_2 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system K01736 GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 0.0000000000001949 71.0
HKD2_k127_375659_0 Putative Na+/H+ antiporter - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005841 574.0
HKD2_k127_375659_1 Protein of unknown function (DUF692) K09930 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000097 373.0
HKD2_k127_375659_2 Ribonuclease H K03469 - 3.1.26.4 0.00000000000000000000000000000006009 140.0
HKD2_k127_375659_3 C4-type zinc ribbon domain K07164 - - 0.0000000000000000000000000000006465 131.0
HKD2_k127_375659_4 Putative DNA-binding domain - - - 0.0000000000000000001518 101.0
HKD2_k127_375659_6 Belongs to the multicopper oxidase YfiH RL5 family K05810 GO:0003674,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016679,GO:0016682,GO:0030312,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0046983,GO:0055114,GO:0071944 - 0.00000109 51.0
HKD2_k127_3760535_0 protein with protein kinase and helix-hairpin-helix DNA-binding domains - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 586.0
HKD2_k127_3760535_1 Protein phosphatase 2C - - - 0.0000000000000000000000000000000000000000000003639 178.0
HKD2_k127_3760535_2 von Willebrand factor, type A - - - 0.0000000000000596 72.0
HKD2_k127_3763288_0 outer membrane efflux protein - - - 0.0000000000000000003673 100.0
HKD2_k127_3763288_1 Bacterial regulatory proteins, tetR family K13770 - - 0.00000000000000000823 91.0
HKD2_k127_3763288_2 TIGRFAM YD repeat protein - - - 0.0000000007474 66.0
HKD2_k127_3769628_0 Ferric uptake regulator family K03711 - - 0.000000000004022 68.0
HKD2_k127_3774741_0 L-seryl-tRNA selenium transferase K01042 - 2.9.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002685 395.0
HKD2_k127_3774741_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001934 403.0
HKD2_k127_3774741_2 TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M K00342 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000727 213.0
HKD2_k127_3781007_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 1.783e-214 705.0
HKD2_k127_3781007_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K07799 - - 0.0000000000000000000000000000000000000000000000000000000429 211.0
HKD2_k127_3784265_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003174 531.0
HKD2_k127_3784265_1 Zinc-uptake complex component A periplasmic K02077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005761 404.0
HKD2_k127_3784265_2 ABC 3 transport family K02075 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005855 396.0
HKD2_k127_3784265_3 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001222 268.0
HKD2_k127_3787635_0 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000485 118.0
HKD2_k127_3787635_1 lyase activity - - - 0.00000004991 64.0
HKD2_k127_379479_0 Belongs to the PstS family K02040 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007277 428.0
HKD2_k127_379479_1 Belongs to the PstS family K02040 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000256 393.0
HKD2_k127_379479_2 probably responsible for the translocation of the substrate across the membrane K02037 - - 0.000000000000000000000000000000000000000005342 158.0
HKD2_k127_3798454_0 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002699 308.0
HKD2_k127_3798454_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000002635 111.0
HKD2_k127_3804899_0 PFAM Nitroreductase - - - 0.0000000000000000000000000000000000004638 146.0
HKD2_k127_3804899_1 TrkA-N domain - - - 0.000000000000000000000000001109 124.0
HKD2_k127_3804899_2 PFAM aldo keto reductase - - - 0.00000000000000000000001989 102.0
HKD2_k127_3807123_0 Sugar (and other) transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002781 356.0
HKD2_k127_3807123_1 Acyltransferase family - - - 0.0000000000000005999 83.0
HKD2_k127_3831721_0 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000665 268.0
HKD2_k127_3831721_1 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan K01778 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 0.0000000000000000000000000000000000000000000000000000002263 211.0
HKD2_k127_3831721_2 PFAM Histidine triad (HIT) protein K19710 - 2.7.7.53 0.000000000000000000000000000000000002243 140.0
HKD2_k127_3831721_3 PFAM BNR Asp-box repeat - - - 0.0000000003943 71.0
HKD2_k127_3831721_4 cellulose binding - - - 0.000838 46.0
HKD2_k127_3838434_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007731 360.0
HKD2_k127_3838434_1 Glycosyl transferases group 1 - - - 0.0000000000000000000000000000000000000000000000000000000000000000002604 254.0
HKD2_k127_3839764_0 FAD dependent oxidoreductase K00303 - 1.5.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004304 483.0
HKD2_k127_3839764_1 Acid phosphatase homologues - - - 0.000000000000000000008929 101.0
HKD2_k127_3845302_0 Two component regulator propeller - - - 0.00000000000000000000000000000000000000000000000000000000001667 233.0
HKD2_k127_3848821_0 PFAM aromatic amino acid beta-eliminating lyase threonine aldolase K01620 - 4.1.2.48 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000597 327.0
HKD2_k127_3848821_1 FAD dependent oxidoreductase K00111 - 1.1.5.3 0.00000000000000000000000000000000000000000000000000000000000000001961 248.0
HKD2_k127_3855759_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003539 385.0
HKD2_k127_3855759_1 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000003457 207.0
HKD2_k127_3861223_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043,K13797 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 7.289e-236 742.0
HKD2_k127_3883564_0 Insulinase (Peptidase family M16) K07263 - - 0.0 1231.0
HKD2_k127_3886008_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007191 321.0
HKD2_k127_3886008_1 protein kinase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000307 246.0
HKD2_k127_3896601_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 8.996e-197 625.0
HKD2_k127_3896601_1 COGs COG0667 oxidoreductase (related to aryl-alcohol dehydrogenase) K05275 - 1.1.1.65 0.00000002403 55.0
HKD2_k127_3902692_0 Heat shock 70 kDa protein K04043 - - 3.982e-231 729.0
HKD2_k127_3902692_1 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons K03705 - - 0.00000000000000000000000000000000000000000000000000000000000000000005713 245.0
HKD2_k127_3902692_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K03686 - - 0.00000000000000000000000000000000000000000000000000002668 192.0
HKD2_k127_3902692_3 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ K03687 GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065 - 0.0000000000000000000000000001959 126.0
HKD2_k127_3902692_4 Integral membrane protein CcmA involved in cell shape determination - - - 0.0000000000000000000002635 102.0
HKD2_k127_3902692_5 phosphoglucomutase phosphomannomutase alpha beta alpha domain I K01840 - 5.4.2.8 0.0000000000000000001648 89.0
HKD2_k127_3902692_6 energy transducer activity K03832 - - 0.0002896 45.0
HKD2_k127_3907576_0 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002135 489.0
HKD2_k127_3907576_1 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001343 303.0
HKD2_k127_3907576_2 helix_turn_helix, Lux Regulon - - - 0.0000000000000000000000000000000000000000000000000000000000000002336 228.0
HKD2_k127_3909192_0 PFAM Aminotransferase class-III K01845 - 5.4.3.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000769 437.0
HKD2_k127_3909192_1 Saccharopine dehydrogenase C-terminal domain K00290 - 1.5.1.7 0.0000000000000000000000722 106.0
HKD2_k127_3943280_0 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane K01546 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031420,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001612 382.0
HKD2_k127_3943280_1 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system K01547 - 3.6.3.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001971 346.0
HKD2_k127_3951147_0 Peptidase M64 N-terminus - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001545 536.0
HKD2_k127_3951147_1 diguanylate cyclase - - - 0.00000000000000000000000000000000000002711 155.0
HKD2_k127_3951147_2 - - - - 0.0000368 49.0
HKD2_k127_3966889_0 PFAM Methylamine utilisation protein MauE - - - 0.000000000000001136 87.0
HKD2_k127_3966889_1 Rhodanese Homology Domain - - - 0.0000000000001432 78.0
HKD2_k127_3966889_2 Involved in DNA repair and RecF pathway recombination K03584 GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - 0.0009458 48.0
HKD2_k127_3967754_0 Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain K03320 - - 0.00000000000000000000000000000000000000000000000000001679 203.0
HKD2_k127_3967754_1 - - - - 0.000000000000000000000000002111 127.0
HKD2_k127_3967754_2 protein conserved in bacteria K09766 - - 0.000000000000000005772 94.0
HKD2_k127_3969809_0 positive regulation of growth rate - - - 0.0000000000000000000000002143 115.0
HKD2_k127_3969809_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K05807 - - 0.00000000000000000001005 103.0
HKD2_k127_3973098_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008638 448.0
HKD2_k127_3973098_1 SMART Tetratricopeptide - - - 0.0000000000008039 79.0
HKD2_k127_3981578_0 Bacterial extracellular solute-binding protein K05813 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003425 282.0
HKD2_k127_3981578_1 - - - - 0.0000000000000000000003003 107.0
HKD2_k127_3988708_0 Helix-hairpin-helix class 2 (Pol1 family) motifs - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005938 362.0
HKD2_k127_3988708_1 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000000001653 84.0
HKD2_k127_3988708_2 ATP-dependent helicase K03579 - 3.6.4.13 0.00000003119 61.0
HKD2_k127_3993496_0 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) K01649 - 2.3.3.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001906 487.0
HKD2_k127_3993496_1 His Kinase A (phosphoacceptor) domain K18351 - 2.7.13.3 0.0000001066 53.0
HKD2_k127_4008154_0 carbon-oxygen lyase activity, acting on polysaccharides - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 311.0
HKD2_k127_4008154_1 Cellulose biosynthesis protein BcsQ K03496 - - 0.0000000000000000000000000000000000000000000000000002324 195.0
HKD2_k127_4011369_0 Predicted periplasmic protein (DUF2092) - - - 0.00000000000000000000000000000000000000000000000324 183.0
HKD2_k127_4011369_1 long-chain fatty acid transport protein - - - 0.00000000000000000000000000008675 128.0
HKD2_k127_4011369_2 Glycogen debranching enzyme - - - 0.000000000000000136 81.0
HKD2_k127_4020166_0 Ftsk_gamma K03466 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002172 573.0
HKD2_k127_4024068_0 Patatin-like phospholipase K02282,K07001 - - 0.00000000000000000000000000000002042 135.0
HKD2_k127_4027250_0 Amino acid permease - GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - 7.524e-233 732.0
HKD2_k127_4027250_1 Phenazine biosynthesis-like protein - - - 0.0000000000000000000000001018 107.0
HKD2_k127_4032202_0 O-acyltransferase activity K00661 - 2.3.1.79 0.00000000000000000000000000000006068 129.0
HKD2_k127_4032202_1 Lysylphosphatidylglycerol synthase TM region K07027 - - 0.00000000000000000000000000000008066 137.0
HKD2_k127_4032202_2 PFAM Glycosyl transferases group 1 - - - 0.000000000000008624 87.0
HKD2_k127_4036052_0 HflC and HflK could encode or regulate a protease K04088 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001047 379.0
HKD2_k127_4036052_1 HflC and HflK could regulate a protease K04087 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001579 393.0
HKD2_k127_4036052_2 lipolytic protein G-D-S-L family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001287 295.0
HKD2_k127_4036052_3 membrane - - - 0.0000000000000000000000000000000001016 151.0
HKD2_k127_4048754_0 e3 binding domain K00658 - 2.3.1.61 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006442 283.0
HKD2_k127_4048754_1 Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate K03801 - 2.3.1.181 0.000000000000000000000000000000000000000000000000000000000000003096 228.0
HKD2_k127_4048754_2 phosphorelay sensor kinase activity K07638,K07673,K21009 - 2.7.13.3 0.00000001359 61.0
HKD2_k127_4056699_0 Belongs to the short-chain dehydrogenases reductases (SDR) family K07124 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005797 246.0
HKD2_k127_4056699_1 Helicase K03579 - 3.6.4.13 0.00000000000000000000000000000000000000000003731 173.0
HKD2_k127_4056699_2 Helicase K03579 - 3.6.4.13 0.00000000000000000000000000000000000001076 157.0
HKD2_k127_4063277_0 serine threonine protein kinase K08884,K12132 GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 0.00000000000000000008179 101.0
HKD2_k127_4063277_1 PilZ domain K08884 - 2.7.11.1 0.000000000002001 78.0
HKD2_k127_4063277_2 - - - - 0.000127 51.0
HKD2_k127_4064679_0 Arginase family K01476 - 3.5.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 289.0
HKD2_k127_4064679_1 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000007945 274.0
HKD2_k127_4064679_2 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) K01868 - 6.1.1.3 0.00000000000000000006071 94.0
HKD2_k127_4065354_0 WD40-like Beta Propeller Repeat - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007191 404.0
HKD2_k127_407610_0 3'-5' exonuclease K03684 - 3.1.13.5 0.00000000000000000000000000000000000000000000000003781 197.0
HKD2_k127_407610_1 Bacterial membrane protein YfhO - - - 0.00000000000000000000002574 110.0
HKD2_k127_4079258_0 Mandelate racemase muconate lactonizing enzyme K02549,K19802 - 4.2.1.113,5.1.1.20 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002128 372.0
HKD2_k127_4079258_1 COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000006973 249.0
HKD2_k127_4087909_0 Phosphate acyltransferases K05939 - 2.3.1.40,6.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001309 394.0
HKD2_k127_4087909_1 Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions K21071 - 2.7.1.11,2.7.1.90 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007814 326.0
HKD2_k127_4090561_0 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity K03182 - 4.1.1.98 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002109 404.0
HKD2_k127_4090561_1 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000007207 314.0
HKD2_k127_4094343_0 Dak1 domain K00863,K05878,K05879 - 2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007064 446.0
HKD2_k127_4094343_1 dihydroxyacetone kinase L subunit - - - 0.0000000000000000000000000000000000000000000000004707 184.0
HKD2_k127_4115884_0 Spore coat protein CotH - - - 0.0000000000000000000000000000000000000000000000004169 199.0
HKD2_k127_4115884_1 pathogenesis - - - 0.0000000000000000000000000000000000000000002214 167.0
HKD2_k127_4115884_2 PFAM Phosphate-selective porin O and P K07221 - - 0.0000000000000000005408 100.0
HKD2_k127_4115884_3 acid phosphatase activity K22390 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000008086 74.0
HKD2_k127_4121344_0 Glycosyltransferase Family 4 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003114 269.0
HKD2_k127_4121344_1 Glycosyl transferase family 2 - - - 0.000000000000000000000000000009966 136.0
HKD2_k127_4124311_0 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.000000000000000000000000002251 126.0
HKD2_k127_4124311_1 Pas domain - - - 0.00000000000000000000001377 111.0
HKD2_k127_4128805_0 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis K06997 - - 0.0000000000000000000000000000000000000000000000000003325 191.0
HKD2_k127_4128805_1 protein kinase activity - - - 0.0000000000000906 76.0
HKD2_k127_4128805_2 Eukaryotic integral membrane protein (DUF1751) - - - 0.0000000000001035 80.0
HKD2_k127_4136522_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002341 398.0
HKD2_k127_4136522_1 conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001283 299.0
HKD2_k127_4136522_2 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP K01525 - 3.6.1.41 0.000000000000000000000000000000000000000000004374 173.0
HKD2_k127_4136522_3 - - - - 0.0000000000004943 82.0
HKD2_k127_4136522_4 von Willebrand factor type A domain K07114 - - 0.00001365 57.0
HKD2_k127_4149581_0 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates K03043 - 2.7.7.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000749 366.0
HKD2_k127_4149581_1 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release K02863 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 317.0
HKD2_k127_4149581_2 Participates in transcription elongation, termination and antitermination K02601 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - 0.0000000000000000000000000000000000000000000000000000000000000000000231 241.0
HKD2_k127_4149581_3 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors K02867 GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.00000000000000000000000000000000000000000000000000000000000001747 217.0
HKD2_k127_4149581_4 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation K02935 - - 0.00000000000000000000000000000000000000005346 155.0
HKD2_k127_4149581_5 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors K02864 GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000008107 143.0
HKD2_k127_4149581_6 Ribosomal protein L33 K02913 - - 0.0000000000000004111 79.0
HKD2_k127_4149581_7 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000003397 75.0
HKD2_k127_4149581_8 Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation K03073 - - 0.000000003032 63.0
HKD2_k127_4150952_0 Dodecin K09165 - - 0.0000000000000000000002483 98.0
HKD2_k127_4150952_1 Protein tyrosine kinase - - - 0.0000000000000002808 87.0
HKD2_k127_416589_0 SpoIVB peptidase S55 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004545 328.0
HKD2_k127_4204044_0 GAF domain K01768 - 4.6.1.1 3.265e-261 827.0
HKD2_k127_4218691_0 Domains REC, PAS, PAS, PP2C K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000000004559 240.0
HKD2_k127_4218691_1 anaphase-promoting complex-dependent catabolic process - - - 0.0000000000000000000000000000000000005434 149.0
HKD2_k127_4218691_2 protein F13E9.13, mitochondrial-like K06971 - - 0.00000000000002518 75.0
HKD2_k127_4234055_0 PFAM Permease for cytosine purines, uracil, thiamine, allantoin K03457 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005183 592.0
HKD2_k127_4234055_1 PFAM amidohydrolase K01464 - 3.5.2.2 0.0000000000000000000000000000000000000000000000622 172.0
HKD2_k127_4234055_2 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K15372 - 2.6.1.55 0.0000000000000000000000000000000111 146.0
HKD2_k127_4238133_0 Predicted Permease Membrane Region K07085 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007654 440.0
HKD2_k127_4253311_0 - - - - 0.00000000000000000000000000000000000000000000000000000000001532 227.0
HKD2_k127_4253311_1 Protein of unknown function (DUF1569) - - - 0.000000000000000000000000000003694 126.0
HKD2_k127_4253311_2 Involved in the TonB-independent uptake of proteins K03641 GO:0003674,GO:0005215,GO:0006810,GO:0008150,GO:0019534,GO:0022857,GO:0051179,GO:0051234,GO:0055085,GO:1901998 - 0.00000000000000000000000001275 121.0
HKD2_k127_4271103_0 PFAM Carbamoyl-phosphate synthase L chain K01955 GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 2.523e-207 656.0
HKD2_k127_4271103_1 Belongs to the CarA family K01956 - 6.3.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000003216 248.0
HKD2_k127_4271103_2 Belongs to the peptidase S26 family K03100 - 3.4.21.89 0.0000000000000000000000000000000000000000000000001856 191.0
HKD2_k127_4271103_3 RDD family - - - 0.0000000000001052 78.0
HKD2_k127_4280105_0 Iron permease FTR1 family K07243 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000005354 311.0
HKD2_k127_4287964_0 SPFH domain / Band 7 family - - - 1.15e-224 715.0
HKD2_k127_4291688_0 DNA polymerase III delta subunit K02340 - 2.7.7.7 0.0000000000000000000000000000000000000000000000000000000000000000000108 246.0
HKD2_k127_4291688_1 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair K01356 - 3.4.21.88 0.0000000000000000000000000000000000000000000000000000000002179 207.0
HKD2_k127_4304065_0 Transglycosylase SLT domain K08309 - - 0.0000000000000000000000000000000000000001488 160.0
HKD2_k127_4304065_1 Mitochondrial biogenesis AIM24 - - - 0.000000000000000001371 99.0
HKD2_k127_4324960_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388,K12527 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000026 296.0
HKD2_k127_4324960_1 Cytochrome b(N-terminal)/b6/petB - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008597 283.0
HKD2_k127_4324960_2 Rieske [2Fe-2S] domain K02636,K03886 - 1.10.9.1 0.000000000000000000000000002972 118.0
HKD2_k127_4329909_0 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B K02274 - 1.9.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003563 478.0
HKD2_k127_4329909_1 PFAM cytochrome c oxidase, subunit III K02276 - 1.9.3.1 0.0000000000000000000000000000000000000000000000000000000000000000000000001415 259.0
HKD2_k127_4329909_2 TIGRFAM Caa(3)-type oxidase, subunit IV K02277 - 1.9.3.1 0.000000000000000002882 90.0
HKD2_k127_4334745_0 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000216 314.0
HKD2_k127_4334745_1 Periplasmic copper-binding protein (NosD) - - - 0.000000000000005248 88.0
HKD2_k127_4334745_2 HEAT repeat - - - 0.0007053 52.0
HKD2_k127_437703_0 Prolyl oligopeptidase, N-terminal beta-propeller domain K01354 - 3.4.21.83 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005292 320.0
HKD2_k127_437703_1 Belongs to the arginase family K01480 - 3.5.3.11 0.000000000000000000000000000000001485 133.0
HKD2_k127_437703_2 peptidase inhibitor activity - - - 0.0000000000004039 78.0
HKD2_k127_4403320_0 Flavin containing amine oxidoreductase K09516 - 1.3.99.23 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000708 361.0
HKD2_k127_4403320_1 - - - - 0.00002848 47.0
HKD2_k127_4412925_0 Belongs to the 'phage' integrase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003614 291.0
HKD2_k127_4412925_1 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) K02527 - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 0.0000000000000000000000000000001998 134.0
HKD2_k127_4413447_0 PFAM EAL domain protein - - - 0.00000000000000000000000000000000000001493 158.0
HKD2_k127_4414379_0 TatD family K03424 - - 0.000000000000000000000000000000000000000000000000000000000000000000000002304 253.0
HKD2_k127_4414379_1 Belongs to the UPF0234 family K09767 - - 0.0000000000000000000000000000000000000000000000000000000001896 207.0
HKD2_k127_4414379_2 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000000001565 203.0
HKD2_k127_4414379_3 Belongs to the FPP GGPP synthase family K02523,K13789 - 2.5.1.1,2.5.1.10,2.5.1.29,2.5.1.90 0.000000000000000000000001644 113.0
HKD2_k127_4419916_0 nitrate reductase beta subunit K00371,K17051 - 1.7.5.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001788 400.0
HKD2_k127_4419916_1 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00370,K07306,K17050 - 1.7.5.1,1.8.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002152 377.0
HKD2_k127_4452193_0 TamB, inner membrane protein subunit of TAM complex K09800 - - 0.00000000000000000007241 104.0
HKD2_k127_4454786_0 Urocanase C-terminal domain K01712 - 4.2.1.49 6.061e-271 841.0
HKD2_k127_4458389_0 Phosphomethylpyrimidine kinase K03272 - 2.7.1.167,2.7.7.70 0.000000000000000000000000000000000000000000000000000000000000000000000000000005455 288.0
HKD2_k127_4458389_1 TIGRFAM geranylgeranyl reductase - - - 0.0000000000000000000000000000000003597 152.0
HKD2_k127_4458389_2 O-Antigen ligase K18814 - - 0.000000000000000000001642 108.0
HKD2_k127_4458389_3 Trm112p-like protein K09791 - - 0.0000000000000002256 81.0
HKD2_k127_4458389_4 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000004035 51.0
HKD2_k127_4462216_0 Squalene--hopene cyclase - - - 0.000000000000000000000000000000001645 132.0
HKD2_k127_4462216_1 PFAM blue (type 1) copper domain protein - - - 0.000000000000006878 89.0
HKD2_k127_4462216_2 - - - - 0.000000002096 70.0
HKD2_k127_4470048_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.00000000000000000000000000000000000000007937 171.0
HKD2_k127_4470048_1 Subtilase family - - - 0.000000007143 62.0
HKD2_k127_4476078_0 Reversible hydration of carbon dioxide K01673 GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000009173 251.0
HKD2_k127_4476078_1 oligopeptide transport K03305 - - 0.000000000000000003193 88.0
HKD2_k127_449099_0 Peptidase family S58 K01266 - 3.4.11.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000001195 294.0
HKD2_k127_449099_1 EamA-like transporter family - - - 0.0000000000000000000000000000005907 128.0
HKD2_k127_4505059_0 DJ-1/PfpI family - - - 0.0000000000000000000000000000000000000000000004123 169.0
HKD2_k127_4505059_1 heat shock protein binding - - - 0.0000000000000026 88.0
HKD2_k127_4509212_0 von Willebrand factor, type A K07114 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000434 278.0
HKD2_k127_4509212_1 Putative adhesin - - - 0.00000000000000004963 89.0
HKD2_k127_4517027_0 involved in lipopolysaccharide - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000285 400.0
HKD2_k127_4517027_1 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008184 355.0
HKD2_k127_4517027_2 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000000000000000000000000000000000008363 207.0
HKD2_k127_4517027_3 PFAM NAD-dependent epimerase dehydratase K01710 - 4.2.1.46 0.000000000000000000000000000000000000000000003173 165.0
HKD2_k127_4522079_0 COG0076 Glutamate decarboxylase and related PLP-dependent K01593 - 4.1.1.105,4.1.1.28 5.696e-222 698.0
HKD2_k127_4522079_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008997 306.0
HKD2_k127_4522079_2 thiolester hydrolase activity - - - 0.0000000000000000000000000000000000000000000000000000000007028 208.0
HKD2_k127_4526023_0 membrane organization - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001851 597.0
HKD2_k127_4528922_0 Protein serine threonine phosphatase K20074 - 3.1.3.16 0.00000000000000000000000000000000000000000000000000000000000000000007827 242.0
HKD2_k127_4528922_1 - - - - 0.0000000000000000000000000000009402 126.0
HKD2_k127_4528922_2 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins K05516 - - 0.00000001106 64.0
HKD2_k127_4536119_0 TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family K03296,K18138 - - 1.013e-244 763.0
HKD2_k127_4536119_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003908 433.0
HKD2_k127_4536119_2 MlaD protein K02067 - - 0.000000000000000000000005495 114.0
HKD2_k127_4552176_0 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate K03639 - 4.1.99.22 0.00000000000000000000000000000000000000000000000000004626 194.0
HKD2_k127_4552176_1 actin binding - - - 0.00000000000000000000000000000000000000000000002986 177.0
HKD2_k127_4552176_2 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000000000000008839 85.0
HKD2_k127_4552176_3 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin K21142 - 2.8.1.12 0.000000000003026 70.0
HKD2_k127_4597540_0 Protein of unknown function (DUF2867) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000202 590.0
HKD2_k127_4597540_1 BNR repeat-like domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002681 330.0
HKD2_k127_4597540_2 Bacteriophage replication gene A protein (GPA) - - - 0.000006251 51.0
HKD2_k127_4609681_0 Trypsin - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004398 396.0
HKD2_k127_4609681_1 MFS/sugar transport protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 379.0
HKD2_k127_4609681_2 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - 0.00000000000000000000000000000000000000000000000000000000001922 209.0
HKD2_k127_4609681_3 PFAM Uncharacterised protein family (UPF0153) K18475 - - 0.000000563 61.0
HKD2_k127_460997_0 PFAM NHL repeat containing protein - - - 1.097e-219 721.0
HKD2_k127_460997_1 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000519 332.0
HKD2_k127_460997_2 FAD binding domain K00103,K16653 - 1.1.3.8,1.1.98.3 0.00000000000000000000000000000000000000000002918 169.0
HKD2_k127_460997_3 May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate K21420 GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 0.000000000000000000000000000000000000000002137 161.0
HKD2_k127_460997_4 M6 family metalloprotease domain protein - - - 0.000000000000000000000000000000005507 149.0
HKD2_k127_4621426_0 Sulfite exporter TauE/SafE K07090 - - 0.0000000000000000000000000000000000000000000000000000000009089 211.0
HKD2_k127_4621426_1 TIGRFAM VWFA-related Acidobacterial domain - - - 0.00000003441 66.0
HKD2_k127_4630748_0 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000000000000000000000000000000000002991 233.0
HKD2_k127_4630748_1 peptidyl-tyrosine sulfation - - - 0.0000008299 62.0
HKD2_k127_4656287_0 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY K03106 - 3.6.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001907 469.0
HKD2_k127_4656287_1 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate K14652 - 3.5.4.25,4.1.99.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 385.0
HKD2_k127_4656287_2 Belongs to the bacterial ribosomal protein bS16 family K02959 - - 0.0000000000000000000002003 99.0
HKD2_k127_4656287_3 Belongs to the UPF0109 family K06960 - - 0.000000000000002827 79.0
HKD2_k127_4656287_4 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes K02860 - - 0.000000000008429 70.0
HKD2_k127_466071_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009828 471.0
HKD2_k127_466071_1 Histidine Phosphotransfer domain - - - 0.00000000007996 66.0
HKD2_k127_4660908_0 PFAM peptidase - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000032 278.0
HKD2_k127_4662174_1 COG0840 Methyl-accepting chemotaxis protein K08738 - - 0.00000001982 61.0
HKD2_k127_4675219_0 PFAM Tetratricopeptide TPR_1 repeat-containing protein - - - 0.0000000000000000002873 102.0
HKD2_k127_467804_0 Glycosyl hydrolase-like 10 - - - 0.00000000000000000000000000000003658 138.0
HKD2_k127_467804_1 outer membrane lipoprotein carrier protein LolA K03634 - - 0.000000000000000000000000265 116.0
HKD2_k127_4678949_0 Hydrolase CocE NonD family - - - 5.635e-306 950.0
HKD2_k127_4678949_1 - - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003565 341.0
HKD2_k127_4678949_2 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000003154 145.0
HKD2_k127_4685481_0 Sulfatase - - - 0.000000000000000000000000000000000000000000000000000004129 210.0
HKD2_k127_4697966_0 aminopeptidase - - - 0.00000000000000000000000000000000000000000000005155 192.0
HKD2_k127_4697966_1 (Hpt) domain K20976 - - 0.00000001071 60.0
HKD2_k127_4698133_0 Polysaccharide biosynthesis protein K01784,K08679 - 5.1.3.2,5.1.3.6 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001045 325.0
HKD2_k127_4698133_1 Belongs to the ribulose-phosphate 3-epimerase family K01783 - 5.1.3.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000001079 268.0
HKD2_k127_4698133_2 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA K03500 - 2.1.1.176 0.0000000000000000000000000000000000000000000000000000000000000002151 234.0
HKD2_k127_4698133_3 acyl-CoA thioester hydrolase, YbgC YbaW family K07107 - - 0.000000000000000000000000000001096 134.0
HKD2_k127_4698133_4 serine threonine protein kinase K08884,K12132 GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 0.00006153 53.0
HKD2_k127_4698348_0 Binding-protein-dependent transport system inner membrane component K05773 - - 0.00000000000000000000000000000000000000000000000000000000000000000001832 240.0
HKD2_k127_4698348_1 PBP superfamily domain K05772 - - 0.0000000000000000000000000000000000000000000000004564 179.0
HKD2_k127_4698348_2 tungstate ion transport K06857 - 3.6.3.55 0.0000000000000000000000000000000005336 144.0
HKD2_k127_4703002_0 RibD C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004603 411.0
HKD2_k127_4703002_1 Glucose inhibited division protein A K21401 - 1.3.99.38 0.000000000000000000000000000000000000000000000000000000000000000000000005577 267.0
HKD2_k127_4703002_2 Chalcone and stilbene synthases, C-terminal domain K16167 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006629,GO:0006725,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009273,GO:0009698,GO:0009699,GO:0009714,GO:0009715,GO:0009987,GO:0016020,GO:0016043,GO:0019438,GO:0019748,GO:0022607,GO:0032991,GO:0034081,GO:0042180,GO:0042181,GO:0042546,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0071944,GO:1901360,GO:1901362,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000001224 244.0
HKD2_k127_4703002_3 Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism K03111 - - 0.0000000000000000000000000000000000002778 147.0
HKD2_k127_4703002_4 Methyltransferase domain - - - 0.00000000000000000000000007904 122.0
HKD2_k127_4703002_5 helix_turn_helix, cAMP Regulatory protein K21564 - - 0.00001502 48.0
HKD2_k127_4705537_0 Pterin binding enzyme K00548,K15023 - 2.1.1.13,2.1.1.258 2.048e-287 895.0
HKD2_k127_4722038_0 COG0044 Dihydroorotase and related cyclic amidohydrolases K01464 - 3.5.2.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000245 535.0
HKD2_k127_4722038_1 Dihydroorotate dehydrogenase K17723 GO:0003674,GO:0003824,GO:0003954,GO:0006139,GO:0006206,GO:0006208,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016651,GO:0034641,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.3.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003328 415.0
HKD2_k127_4729717_0 dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000000000000000000000000000000000000000000005456 181.0
HKD2_k127_4729717_1 Histidine kinase-like ATPase domain K04757 - 2.7.11.1 0.000000000000000000000000008933 115.0
HKD2_k127_4747959_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K07787 - - 0.0 1178.0
HKD2_k127_4749215_0 Polysaccharide biosynthesis protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 351.0
HKD2_k127_4749215_1 PFAM Glycosyl transferase, group 1 - - - 0.000000000000000000000000584 118.0
HKD2_k127_4778804_0 Adenylate kinase K00939 - 2.7.4.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001019 385.0
HKD2_k127_4778804_1 Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE K03695 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002163 376.0
HKD2_k127_4808248_0 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine K00831 - 2.6.1.52 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001375 560.0
HKD2_k127_4808248_1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding K00058 - 1.1.1.399,1.1.1.95 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001962 337.0
HKD2_k127_4808248_2 cytochrome complex assembly K02200,K04018 - - 0.0000000000000000000000000000000000004148 151.0
HKD2_k127_4813823_0 energy transducer activity - - - 0.0000001357 64.0
HKD2_k127_4820265_0 Beta-eliminating lyase K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000665 361.0
HKD2_k127_4820265_1 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions K01462 - 3.5.1.88 0.00000000000000000000000000000000000000000000003343 183.0
HKD2_k127_4820265_2 Trypsin-like peptidase domain - - - 0.0000000000000000000001728 102.0
HKD2_k127_4826873_0 PIN domain - - - 0.0000000000002304 77.0
HKD2_k127_4861071_0 Domain of unknown function (DUF4388) - - - 0.000000000000000000000000000000000000000000000000000000003852 214.0
HKD2_k127_4861071_1 Belongs to the ribF family K11753 GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008531,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009124,GO:0009156,GO:0009161,GO:0009165,GO:0009231,GO:0009259,GO:0009260,GO:0009398,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0042364,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046390,GO:0046444,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.26,2.7.7.2 0.0000000000000000000000000000000000001427 148.0
HKD2_k127_4862882_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision K03703 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002244 548.0
HKD2_k127_4862882_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K00995 - 2.7.8.5 0.0000000000000000000000000000000000000000223 160.0
HKD2_k127_4862882_2 Domain of unknown function (DUF4442) - - - 0.000000000000000000000000008133 129.0
HKD2_k127_4862882_3 Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor K03752 - 2.7.7.77 0.00000000006939 69.0
HKD2_k127_486586_0 Amidohydrolase family - - - 0.00000000000000000000000000000000000000000000000000004444 194.0
HKD2_k127_486586_1 Ligated ion channel L-glutamate- and glycine-binding site K02030,K10036 - - 0.000000000000547 81.0
HKD2_k127_486586_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.0001341 45.0
HKD2_k127_4889269_0 ATPase activity K01990,K19340 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001796 301.0
HKD2_k127_4889269_1 ABC-2 family transporter protein K01992 - - 0.000000000000000000001723 109.0
HKD2_k127_4889269_2 - - - - 0.000000000000001099 81.0
HKD2_k127_4889269_4 Putative porin - - - 0.0006192 51.0
HKD2_k127_489923_0 ABC1 family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006004 351.0
HKD2_k127_489923_1 MgtE intracellular N domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001575 273.0
HKD2_k127_489923_2 Belongs to the P-Pant transferase superfamily K06133 - - 0.00000000000000000000000000000000000000000000000000000000000002171 226.0
HKD2_k127_4906210_0 Alpha amylase, catalytic domain - - - 6.426e-217 683.0
HKD2_k127_4906210_1 hydrolase activity, acting on ester bonds - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003156 269.0
HKD2_k127_4914063_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 1.408e-233 731.0
HKD2_k127_4914063_1 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000001736 162.0
HKD2_k127_4916972_0 exonuclease activity K16899 - 3.6.4.12 0.0000000000000000000000001449 121.0
HKD2_k127_4916972_1 Belongs to the CDP-alcohol phosphatidyltransferase class-I family K17103 - 2.7.8.8 0.0000000004695 60.0
HKD2_k127_4919772_0 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis K03665 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001582 385.0
HKD2_k127_4919772_1 Belongs to the SUA5 family K07566 - 2.7.7.87 0.000000000000000000000000000000000000001628 154.0
HKD2_k127_4922309_0 COG2202 FOG PAS PAC domain - - - 0.0000000000000000000000000004046 131.0
HKD2_k127_4922309_1 Elongation factor SelB winged helix K03833 - - 0.000000000000000000000000001594 111.0
HKD2_k127_4922309_2 Diguanylate cyclase - - - 0.000000000000000000002935 109.0
HKD2_k127_4926338_0 Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities K01782 GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 5.433e-203 653.0
HKD2_k127_4926338_1 CoA-transferase family III K01796 - 5.1.99.4 0.0000000000000000000000000000000005153 138.0
HKD2_k127_4947808_0 SMART AAA ATPase K02450 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001002 295.0
HKD2_k127_4947808_1 Alpha/beta hydrolase family K07020 - - 0.000000000000000000000000000000000000001363 156.0
HKD2_k127_4969928_0 Endothelin-converting enzyme K01415,K07386 - 3.4.24.71 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009182 374.0
HKD2_k127_4969928_1 tRNA pseudouridine synthase activity K06173 GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005911 293.0
HKD2_k127_4969928_2 polysaccharide catabolic process K03478 - 3.5.1.105 0.000000000000000000000000000000005771 135.0
HKD2_k127_5001480_0 Dienelactone hydrolase family - - - 6.57e-226 719.0
HKD2_k127_5001480_1 Predicted permease K07089 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 428.0
HKD2_k127_5001480_2 TIGRFAM redox-active disulfide protein 2 - - - 0.00000000000004814 84.0
HKD2_k127_5003614_0 Subtilase family - - - 0.000000000000000000000000008572 126.0
HKD2_k127_5003614_1 cellulase activity - - - 0.00000000000000000000005784 114.0
HKD2_k127_5009282_0 PFAM FGGY family of carbohydrate kinases, N-terminal domain K00854 - 2.7.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001736 315.0
HKD2_k127_5009282_1 PFAM DeoC LacD family aldolase K11645 - 4.1.2.13 0.0000000000000000000000000000000000000000000000000000000000000006844 239.0
HKD2_k127_5014013_0 surface antigen variable number - - - 0.000000000000000000000000000003311 131.0
HKD2_k127_5014013_1 peptidyl-tyrosine sulfation - - - 0.00000000005184 71.0
HKD2_k127_5032379_0 HlyD family secretion protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002016 308.0
HKD2_k127_5032379_1 Outer membrane efflux protein - - - 0.0000000002039 64.0
HKD2_k127_5053103_0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K01955 - 6.3.5.5 2.099e-217 686.0
HKD2_k127_5053103_1 esterase of the alpha-beta hydrolase superfamily K07001 - - 0.000000000000000000002689 104.0
HKD2_k127_5053103_2 Pfam SNARE associated Golgi protein K03975 - - 0.0001975 48.0
HKD2_k127_5056264_0 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL K01952 - 6.3.5.3 6.613e-234 738.0
HKD2_k127_5069414_0 Voltage gated chloride channel K03281 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000009401 290.0
HKD2_k127_5069414_1 Elongator protein 3, MiaB family, Radical SAM - - - 0.0000000000000002732 90.0
HKD2_k127_5087943_0 Transaldolase/Fructose-6-phosphate aldolase - - - 2.678e-219 696.0
HKD2_k127_5087943_1 Ppx GppA phosphatase K01524 - 3.6.1.11,3.6.1.40 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007357 355.0
HKD2_k127_5087943_2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily K01759 - 4.4.1.5 0.000000000000000000000000000000000003404 150.0
HKD2_k127_5087943_3 Signal peptidase (SPase) II K03101 - 3.4.23.36 0.0000000000000000000000002112 119.0
HKD2_k127_5087943_4 TIGRFAM phosphohistidine phosphatase SixA K08296 - - 0.000000000000000000004513 104.0
HKD2_k127_5125956_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296 - - 2.135e-228 727.0
HKD2_k127_5152454_0 Amino acid permease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002674 508.0
HKD2_k127_5161874_0 Belongs to the sigma-70 factor family. ECF subfamily K03088 - - 0.0000000000000000000000000000000000000001428 157.0
HKD2_k127_5161874_1 Pyridoxamine 5'-phosphate oxidase K07006 - - 0.0000000000000000000000000000000000579 137.0
HKD2_k127_5161874_2 Putative zinc-finger - - - 0.000001368 59.0
HKD2_k127_5161874_3 Protein of unknown function (DUF1059) - - - 0.0000413 53.0
HKD2_k127_5162879_0 Phosphoribosylformylglycinamidine cyclo-ligase K01933 - 6.3.3.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004794 313.0
HKD2_k127_5162879_1 Belongs to the FPP GGPP synthase family K13789 - 2.5.1.1,2.5.1.10,2.5.1.29 0.000000000000000000000000000000000000000000000000000000001247 211.0
HKD2_k127_516595_0 Calcineurin-like phosphoesterase - - - 0.000000000000000000000000000000000000000000000000000000000000003463 231.0
HKD2_k127_5175030_0 metal-dependent membrane protease K07052 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005363 251.0
HKD2_k127_5177130_0 lipolytic protein G-D-S-L family - - - 0.000000000000000000000000001394 130.0
HKD2_k127_5177130_1 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.000000000000008466 87.0
HKD2_k127_5177244_0 4Fe-4S dicluster domain K00184 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002785 532.0
HKD2_k127_5177244_1 Cytochrome c7 and related cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000001912 225.0
HKD2_k127_5188592_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000879 241.0
HKD2_k127_5188592_1 Transcriptional regulatory protein, C terminal - - - 0.000000000000000000000000000000000005652 144.0
HKD2_k127_5191139_0 Alpha amylase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008029 322.0
HKD2_k127_5191139_1 Two component, sigma54 specific, transcriptional regulator, Fis family K13599 - - 0.000000000000000000000000005049 115.0
HKD2_k127_5193074_0 B12 binding domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001081 328.0
HKD2_k127_5193074_1 - - - - 0.00000000000000001087 85.0
HKD2_k127_5196242_0 Peptidase family S41 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008091 295.0
HKD2_k127_5208985_1 - - - - 0.000000000000004726 84.0
HKD2_k127_5208985_2 COG0457 FOG TPR repeat - - - 0.00001132 51.0
HKD2_k127_5228342_0 TPR repeat - - - 0.00000000000000000000000000000000000000000000009818 185.0
HKD2_k127_5228342_1 C4-type zinc ribbon domain K07164 - - 0.00000000000006359 76.0
HKD2_k127_5234560_0 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate K03431 - 5.4.2.10 0.0000000000000000000000000000000000000000000000000000000007602 209.0
HKD2_k127_5234560_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria - - - 0.00000000000000000000000000000000000000000000002202 175.0
HKD2_k127_5234560_2 PFAM YbbR family protein - - - 0.0000000000000000000000003974 116.0
HKD2_k127_5238967_0 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 - 2.4.1.129 0.00000000000000000000000000000000000000000000000000000000192 216.0
HKD2_k127_5238967_1 PIN domain - - - 0.00000000000000000009988 95.0
HKD2_k127_5238967_2 Bacterial antitoxin of type II TA system, VapB - - - 0.000000000000002927 80.0
HKD2_k127_5254464_0 ABC transporter K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000894 319.0
HKD2_k127_5254464_1 PFAM Amidohydrolase family K01468 - 3.5.2.7 0.0000000000000000000000000000000000000000000000000000000000000009939 226.0
HKD2_k127_5259830_0 TIGRFAM ribonuclease, Rne Rng family K08300,K08301 - 3.1.26.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006869 506.0
HKD2_k127_5259830_1 Peptidoglycan polymerase that is essential for cell wall elongation K05837 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000006923 293.0
HKD2_k127_5259830_2 Penicillin-binding protein 2 K05515 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 0.00000000000000000001154 95.0
HKD2_k127_5260884_0 Ankyrin repeat - - - 0.0000000000000000003477 98.0
HKD2_k127_5260884_1 Antibiotic biosynthesis monooxygenase K11530 - 5.3.1.32 0.000000000007807 69.0
HKD2_k127_5260884_2 HEAT repeat - - - 0.00000004094 66.0
HKD2_k127_5264341_0 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives K00796,K18824 GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000005164 279.0
HKD2_k127_5264341_1 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria K18672 - 2.7.7.85 0.0000000000000000003429 92.0
HKD2_k127_5264341_2 FtsH Extracellular K03798 - - 0.0002323 46.0
HKD2_k127_5276471_0 Belongs to the peptidase M48B family K03799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 331.0
HKD2_k127_5276471_1 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) K13832 - 1.1.1.25,4.2.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000004815 293.0
HKD2_k127_5276471_2 cheY-homologous receiver domain - - - 0.000000000000000000000000984 105.0
HKD2_k127_5283978_0 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit K01903 - 6.2.1.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008247 482.0
HKD2_k127_5283978_1 FKBP-type peptidyl-prolyl cis-trans isomerase K01802,K03772 - 5.2.1.8 0.0000000000000000000000000000000000000000000000004545 178.0
HKD2_k127_5283978_2 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit K01902 - 6.2.1.5 0.00000000000000000000000001779 124.0
HKD2_k127_5285770_0 purine nucleobase transmembrane transporter activity K06901 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001926 340.0
HKD2_k127_5285770_1 Cytidylyltransferase K07257 - - 0.000000000000000000000000000000000000000000000005544 183.0
HKD2_k127_5287182_0 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome K02355 - - 3.987e-259 811.0
HKD2_k127_5287182_1 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis K02358 - - 0.000000000000000000000000000008165 119.0
HKD2_k127_5301431_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001633 480.0
HKD2_k127_5301431_1 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM K11178 - 1.17.1.4 0.0006993 48.0
HKD2_k127_5308060_0 Type II secretion system (T2SS), protein F K02455,K02653 GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002428 335.0
HKD2_k127_5308060_1 Type II secretion system (T2SS), protein G K02456 - - 0.00000000000000000000000000000008169 141.0
HKD2_k127_5337709_0 AMP-binding enzyme K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000287 571.0
HKD2_k127_5337709_1 LysM domain protein K07261 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000173 261.0
HKD2_k127_5346764_0 cystathionine gamma-synthase activity K01739,K01760,K01761 - 2.5.1.48,4.4.1.11,4.4.1.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001144 403.0
HKD2_k127_5346764_1 Cytochrome c3 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001998 374.0
HKD2_k127_5346764_2 denitrification pathway - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001115 273.0
HKD2_k127_5351122_0 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis K00973 - 2.7.7.24 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001348 415.0
HKD2_k127_5351122_1 4Fe-4S single cluster domain of Ferredoxin I - - - 0.000000000000000000000000000000000000000000000000000000000000000001294 249.0
HKD2_k127_5351122_2 peptidyl-tyrosine sulfation - - - 0.0000002352 64.0
HKD2_k127_5354517_0 CarboxypepD_reg-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001912 270.0
HKD2_k127_5369704_0 cell shape determining protein MreB K03569 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000544 545.0
HKD2_k127_5369704_1 rod shape-determining protein MreC K03570 - - 0.00000000000000000000000000000000002629 145.0
HKD2_k127_5369704_2 shape-determining protein MreD K03571 - - 0.0009541 50.0
HKD2_k127_5369714_0 Bifunctional purine biosynthesis protein PurH K00602 - 2.1.2.3,3.5.4.10 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006684 477.0
HKD2_k127_5378387_0 malonyl CoA-acyl carrier protein transacylase K00645 - 2.3.1.39 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006756 342.0
HKD2_k127_5378387_1 Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA K03621 - 2.3.1.15 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006874 287.0
HKD2_k127_5378387_2 short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.0000000000000000000000000000000000000000000000000000000000000000000000000002551 278.0
HKD2_k127_5416624_0 Belongs to the thiolase family K00626 - 2.3.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000429 448.0
HKD2_k127_5416624_1 Protein of unknown function (DUF721) - - - 0.0003865 49.0
HKD2_k127_5424513_0 Acts as a magnesium transporter K06213 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000553 417.0
HKD2_k127_5424513_1 PFAM Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009117 338.0
HKD2_k127_5427711_0 May be involved in recombinational repair of damaged DNA K03631 - - 0.000000000000000000000000000000000000000000000000000000000000000000002061 248.0
HKD2_k127_5427711_1 MotA/TolQ/ExbB proton channel family K03561,K03562 - - 0.000000002405 64.0
HKD2_k127_5428637_0 Spermine spermidine synthase K00797 - 2.5.1.16 0.0000000000000000000001499 106.0
HKD2_k127_5447620_0 Alpha-glucan phosphorylase K00688 - 2.4.1.1 4.012e-219 697.0
HKD2_k127_5447620_1 A domain family that is part of the cupin metalloenzyme superfamily. K18850 GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0018193,GO:0018195,GO:0019538,GO:0030961,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901564 1.14.11.47 0.0000000000000000000007301 96.0
HKD2_k127_5451613_0 Heat shock 70 kDa protein K04043 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005105 422.0
HKD2_k127_5451613_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005085 407.0
HKD2_k127_5451613_2 Belongs to the small heat shock protein (HSP20) family K13993 - - 0.00000000000000000000000000000000000000000003704 179.0
HKD2_k127_5451613_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 - - 0.0000000000000000000000000000000008864 135.0
HKD2_k127_5453934_0 Dienelactone hydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001047 279.0
HKD2_k127_5453934_1 DDE superfamily endonuclease - - - 0.000000000000000000000000000000000004066 153.0
HKD2_k127_5453934_2 Prolyl 4-hydroxylase alpha subunit homologues. - - - 0.0000000000000000000003259 104.0
HKD2_k127_5453934_3 2OG-Fe(II) oxygenase superfamily - - - 0.000000000000000000002186 100.0
HKD2_k127_5453934_4 beta-lactamase activity - - - 0.000001623 52.0
HKD2_k127_5454214_0 dipeptide transport K02035 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000001341 289.0
HKD2_k127_5465164_0 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001776 579.0
HKD2_k127_5465164_1 Protease prsW family - - - 0.00000000000000000000000000006217 135.0
HKD2_k127_5486364_0 Transposase IS116/IS110/IS902 family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004696 443.0
HKD2_k127_549031_0 4Fe-4S single cluster domain K06937 - - 3.824e-237 739.0
HKD2_k127_5525557_0 Putative citrate transport - - - 0.00000000000000000000000000000000000000000000002516 173.0
HKD2_k127_5525557_1 HAD-hyrolase-like K01091 - 3.1.3.18 0.000000000000000000000000000000000000000000000109 183.0
HKD2_k127_5525557_2 Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif K02493 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 0.000000000000000000000000000000000000000000145 165.0
HKD2_k127_5540246_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005535 468.0
HKD2_k127_5540246_1 Evidence 2b Function of strongly homologous gene - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005505 405.0
HKD2_k127_556263_0 oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor K00311 GO:0003674,GO:0003824,GO:0004174,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016645,GO:0016649,GO:0016722,GO:0017133,GO:0019866,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032592,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043783,GO:0044237,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045251,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070013,GO:0098573,GO:0098798,GO:1902494,GO:1990204 1.5.5.1 1.92e-218 693.0
HKD2_k127_556263_1 peptidyl-lysine modification to peptidyl-hypusine K00809 - 2.5.1.46 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000101 454.0
HKD2_k127_556263_2 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000003836 291.0
HKD2_k127_556263_3 Protein of unknown function (DUF4013) - - - 0.0000000000000000000000004429 114.0
HKD2_k127_556263_4 protein conserved in bacteria - - - 0.0000000000000000009793 97.0
HKD2_k127_556263_5 histone H2A K63-linked ubiquitination - - - 0.0000001315 64.0
HKD2_k127_5572461_0 D-isomer specific 2-hydroxyacid dehydrogenase catalytic K00058 - 1.1.1.399,1.1.1.95 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001191 457.0
HKD2_k127_5572461_1 Protein of unknown function (DUF1015) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004318 431.0
HKD2_k127_5572461_2 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000003576 164.0
HKD2_k127_5572461_3 Diguanylate cyclase phosphodiesterase with PAS PAC - - - 0.0000000000000000000000000000009638 133.0
HKD2_k127_5580675_0 Cytochrome c - - - 0.000000000000000000000000000000000000000000000000000000000886 209.0
HKD2_k127_5580675_1 NUDIX domain - - - 0.0000000000000000000000000000000002968 139.0
HKD2_k127_5580675_2 MoaE protein K03635,K21142 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 0.00000000000000000000003599 101.0
HKD2_k127_5595696_0 Acyl-CoA dehydrogenase, C-terminal domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003423 368.0
HKD2_k127_5595696_1 Methionine biosynthesis protein MetW - - - 0.00000000000000000000000000000000000000000000000000000008212 224.0
HKD2_k127_5595696_2 Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors K03814 GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008955,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.129 0.00000000000000000000000000000000000000000000000435 183.0
HKD2_k127_5595696_3 PFAM CBS domain K04767 - - 0.0000000000000000001616 94.0
HKD2_k127_5603562_0 Domain of unknown function (DUF4388) - - - 0.00000000000008327 84.0
HKD2_k127_5603562_1 transferase activity, transferring acyl groups other than amino-acyl groups K03466 - - 0.0002536 51.0
HKD2_k127_5603562_2 Tetratricopeptide repeat - - - 0.0009864 51.0
HKD2_k127_5607318_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01887 - 6.1.1.19 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004379 527.0
HKD2_k127_5607318_1 PFAM Peptidase C26 K07010 - - 0.00000000000000000000000000000000000000000000000000000000000009705 232.0
HKD2_k127_5610847_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.00000000000000000000000000000000137 137.0
HKD2_k127_5610847_1 Sulfatase K01138 - - 0.000000000000000000000000134 122.0
HKD2_k127_5629151_0 cellulose binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001107 267.0
HKD2_k127_5629151_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000000000000000000000000000000000000000000000002211 226.0
HKD2_k127_5629151_2 HD domain K01768,K02584,K02660,K07315,K08968,K17763 - 1.8.4.14,3.1.3.3,4.6.1.1 0.0000000003274 73.0
HKD2_k127_5638710_0 Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle K01596 GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009607,GO:0009987,GO:0009991,GO:0010106,GO:0016020,GO:0019725,GO:0030003,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043207,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071944,GO:0075136,GO:0098771 4.1.1.32 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001246 568.0
HKD2_k127_5638710_1 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - - 0.000000000000000000000000000000000003312 152.0
HKD2_k127_5652664_0 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP K03544 GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005444 525.0
HKD2_k127_5652664_1 Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins K01358 - 3.4.21.92 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009628 299.0
HKD2_k127_5652664_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.000000000000000000000000000000000000000000000000000000001658 206.0
HKD2_k127_5661930_0 Mechanosensitive ion channel - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000189 271.0
HKD2_k127_5661930_1 - - - - 0.000000000000001363 86.0
HKD2_k127_5661930_2 Domain of unknown function (DUF4115) K15539 - - 0.000000000000001376 81.0
HKD2_k127_5661930_3 peptidyl-tyrosine sulfation - - - 0.00008661 49.0
HKD2_k127_5661930_4 - - - - 0.0001453 51.0
HKD2_k127_5664687_0 Belongs to the NiFe NiFeSe hydrogenase large subunit family K00436 - 1.12.1.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004544 346.0
HKD2_k127_5664687_1 hydrogenase maturation protease - - - 0.000000000000000000000000000003197 125.0
HKD2_k127_5664687_2 Transcriptional regulatory protein, C terminal K02483 - - 0.0000000000009634 75.0
HKD2_k127_5674493_0 Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system K17215 - - 0.0000000000000000000000000000000000000000000000000000000000001314 224.0
HKD2_k127_5674493_1 PFAM periplasmic binding protein LacI transcriptional regulator K10439 - - 0.00004439 54.0
HKD2_k127_5676434_0 CobQ CobB MinD ParA nucleotide binding domain K08252,K13661,K16554,K16692 - 2.7.10.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000003245 308.0
HKD2_k127_5676757_0 TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain K01905,K22224 - 6.2.1.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002054 562.0
HKD2_k127_5676757_1 Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - 0.0001416 53.0
HKD2_k127_5677470_0 Amino acid permease - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003695 417.0
HKD2_k127_5682119_0 Thioredoxin - - - 0.0000000000000000000000000000000000000000000000000000000000000007163 231.0
HKD2_k127_5692441_0 lipoprotein localization to outer membrane K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001005 421.0
HKD2_k127_5692441_1 PFAM ABC transporter - - - 0.000000000000000000000000000000000000000000000000000000000001579 210.0
HKD2_k127_5692441_2 ribonuclease BN K07058 - - 0.0000000000000000001752 102.0
HKD2_k127_5704954_0 translation initiation factor activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003883 348.0
HKD2_k127_5708232_0 Involved in the import of queuosine (Q) precursors, required for Q precursor salvage K09125 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003775 324.0
HKD2_k127_5708232_1 PFAM Transglycosylase-associated protein - - - 0.000000000000000000000003229 104.0
HKD2_k127_5708232_2 acetyltransferase - - - 0.000000000000000002553 92.0
HKD2_k127_5711410_0 Probably functions as a manganese efflux pump - - - 0.000000000000000000000000000000000001831 158.0
HKD2_k127_5711410_1 manganese ion transmembrane transporter activity - - - 0.000000000144 72.0
HKD2_k127_5715353_0 Belongs to the dCTP deaminase family K01494 - 3.5.4.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001131 308.0
HKD2_k127_5715353_1 AAA domain K02450 - - 0.0000000000000000000000000000000000000000000000000000000000000005305 240.0
HKD2_k127_5715353_2 oligopeptide transport K03305 - - 0.00000000000000000000000000009539 119.0
HKD2_k127_5716460_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005,K13888 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001919 294.0
HKD2_k127_5716460_1 Outer membrane drug efflux lipoprotein K18139 - - 0.0000000000000000000000000000000000000000000000000000000000000001283 226.0
HKD2_k127_5716460_2 ABC transporter K02003 - - 0.00003529 49.0
HKD2_k127_5719929_0 Serine threonine protein kinase K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001527 488.0
HKD2_k127_5719929_1 Tetratricopeptide repeats K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003225 347.0
HKD2_k127_5719929_2 Peptidase family M3 K01414 - 3.4.24.70 0.00000000001227 78.0
HKD2_k127_572044_0 Synthesizes alpha-1,4-glucan chains using ADP-glucose K00703 GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 443.0
HKD2_k127_572044_1 Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits K02528 - 2.1.1.182 0.00000000000000000000000000000000000000000001325 168.0
HKD2_k127_572135_0 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - 1.225e-197 631.0
HKD2_k127_572135_1 ABC transporter K02003 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002641 306.0
HKD2_k127_572135_2 WD40 domain protein beta Propeller K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001537 304.0
HKD2_k127_5730457_0 Sigma-70 region 2 K03088 - - 0.00000000000000000007024 91.0
HKD2_k127_5730457_1 Putative adhesin - - - 0.0000000000000001477 93.0
HKD2_k127_5730457_2 - - - - 0.000001158 59.0
HKD2_k127_573305_0 Pyridine nucleotide-disulphide oxidoreductase - - - 0.0 1333.0
HKD2_k127_573305_1 Removes 5-oxoproline from various penultimate amino acid residues except L-proline K01304 - 3.4.19.3 0.0000000000000000000000000000000000000000000000000000000005593 210.0
HKD2_k127_573305_2 - - - - 0.0000000007546 63.0
HKD2_k127_573305_3 Protein of unknown function (DUF979) - - - 0.000009607 47.0
HKD2_k127_5733557_0 ABC-type transport system involved in lysophospholipase L1 biosynthesis ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000000000000000000002464 246.0
HKD2_k127_5733557_1 GDSL-like Lipase/Acylhydrolase family K10804 - 3.1.1.5 0.000000000000000000000000000000000000000000000000000000000000003187 231.0
HKD2_k127_5733557_2 Serine aminopeptidase, S33 K07019 - - 0.00000000000000000000000000000000000000000000002764 184.0
HKD2_k127_5733557_3 FtsX-like permease family K02004 - - 0.0000000000000000000000000000000000001163 158.0
HKD2_k127_5733908_0 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase K02356 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000007605 250.0
HKD2_k127_5733908_1 Thymidine kinase K00857 - 2.7.1.21 0.0000000000000000000000000000000000000000000000000000000000000000002457 237.0
HKD2_k127_5733908_2 Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP K01974 - 6.5.1.4 0.00000000000000000000006883 109.0
HKD2_k127_5733908_3 GHMP kinases N terminal domain K07031 - 2.7.1.168 0.0000000000000000000001468 102.0
HKD2_k127_574325_0 Thiolase, C-terminal domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001395 496.0
HKD2_k127_574325_1 Alpha/beta hydrolase family K01055 - 3.1.1.24 0.00000000000000002229 96.0
HKD2_k127_574325_2 Alpha/beta hydrolase family - - - 0.0005501 52.0
HKD2_k127_5752460_0 two component, sigma54 specific, transcriptional regulator, Fis family K02481,K07713 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001979 373.0
HKD2_k127_5752460_1 GAF domain - - - 0.0000000000000000000000000000000000000000000000000001898 197.0
HKD2_k127_5752460_2 response regulator K02481,K07713 - - 0.000000000000000003622 97.0
HKD2_k127_5758529_0 NADH oxidase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004863 376.0
HKD2_k127_5783540_0 Enoyl-CoA hydratase/isomerase K01692 - 4.2.1.17 0.00000000000000000000000000000000002091 145.0
HKD2_k127_5783540_1 SNARE associated Golgi protein - - - 0.0000000000000000000002233 104.0
HKD2_k127_5783540_2 Elongator protein 3, MiaB family, Radical SAM - - - 0.00000000000000001095 87.0
HKD2_k127_5792148_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000204 362.0
HKD2_k127_5792148_1 Protein of unknown function DUF58 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001901 267.0
HKD2_k127_5792148_2 Lipid A 3-O-deacylase (PagL) - - - 0.00000000000000000000000000000000000000000000000000000002551 201.0
HKD2_k127_5792148_3 Acid phosphatase homologues - - - 0.0000000000000006542 87.0
HKD2_k127_57946_0 Belongs to the MlaE permease family K02066 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002297 265.0
HKD2_k127_57946_1 ABC transporter K02065 - - 0.0000000000000000000000000000000000000000000000000000009073 212.0
HKD2_k127_57946_2 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000004015 188.0
HKD2_k127_57946_3 protein-N-terminal glutamine amidohydrolase activity K21286 GO:0003008,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0007610,GO:0007611,GO:0007612,GO:0007635,GO:0008150,GO:0008152,GO:0008306,GO:0008355,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019538,GO:0030163,GO:0032501,GO:0036211,GO:0042048,GO:0042221,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050877,GO:0050890,GO:0050896,GO:0070773,GO:0071704,GO:1901564,GO:1901565,GO:1901575 3.5.1.122 0.00000000000000000000000000000447 131.0
HKD2_k127_57946_4 RESPONSE REGULATOR receiver - - - 0.000001062 55.0
HKD2_k127_57946_5 PFAM ABC transporter K02028 - 3.6.3.21 0.00001748 50.0
HKD2_k127_5825076_0 phosphoserine phosphatase activity K07315 - 3.1.3.3 0.000000000000000000000000000000000000000000000000000000000000276 231.0
HKD2_k127_5825076_1 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism K03685 - 3.1.26.3 0.000000000000000000000007601 104.0
HKD2_k127_5825741_0 Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate K01679 - 4.2.1.2 1.502e-215 677.0
HKD2_k127_5825741_1 PFAM Helicase conserved C-terminal domain K17675 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000001149 230.0
HKD2_k127_5825741_2 response regulator receiver K03413 - - 0.0000000000000000000000000000000000549 138.0
HKD2_k127_5825741_3 Lrp/AsnC ligand binding domain - - - 0.000000000000000000000000000003096 122.0
HKD2_k127_583438_0 Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily K01710 - 4.2.1.46 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005525 374.0
HKD2_k127_583438_1 Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose K01790 - 5.1.3.13 0.0000000000000000000000000000000000000000000000000000000000000000000003096 243.0
HKD2_k127_583438_2 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - - 0.000000000000000000000000000000000000000000000001102 183.0
HKD2_k127_5842671_0 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002451 463.0
HKD2_k127_5842671_1 to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001476 400.0
HKD2_k127_5842671_2 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan K01928 - 6.3.2.13 0.000000002666 59.0
HKD2_k127_5843475_0 PFAM Cytochrome b b6 domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001562 293.0
HKD2_k127_5843475_1 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000006259 193.0
HKD2_k127_5861352_0 Aromatic amino acid lyase K01745 - 4.3.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001114 547.0
HKD2_k127_5864828_0 Methyltransferase K06969 - 2.1.1.191 0.000000000000000000000000000000000000000000000000000000000000000001772 243.0
HKD2_k127_5864828_1 Serine hydroxymethyltransferase K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000002937 162.0
HKD2_k127_5864828_2 Ribose/Galactose Isomerase K01808 - 5.3.1.6 0.0000000000000000000000000000000000005715 152.0
HKD2_k127_5864828_3 Integral membrane protein CcmA involved in cell shape determination - - - 0.00000003525 65.0
HKD2_k127_586620_0 Phosphoenolpyruvate phosphomutase K01637 - 4.1.3.1 1.863e-211 676.0
HKD2_k127_586620_1 Malate synthase K01638 - 2.3.3.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000892 344.0
HKD2_k127_586880_0 helix_turn_helix gluconate operon transcriptional repressor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002996 378.0
HKD2_k127_586880_1 YjgF/chorismate_mutase-like, putative endoribonuclease - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002469 265.0
HKD2_k127_586880_2 Pyrroline-5-carboxylate reductase K00286 GO:0003674,GO:0003824,GO:0004735,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 0.000008758 48.0
HKD2_k127_586988_0 Replicative DNA helicase K02314 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003367 421.0
HKD2_k127_586988_1 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function K04485 - - 0.00000000000009133 72.0
HKD2_k127_5870614_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00343 - 1.6.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005572 392.0
HKD2_k127_5870614_1 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.00000000000000000000000000000000001929 141.0
HKD2_k127_5870614_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00340,K05576 - 1.6.5.3 0.0000000000000000000000005138 115.0
HKD2_k127_5872711_0 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003091 292.0
HKD2_k127_5873146_0 Protein of unknown function (DUF3999) - - - 0.00000000000000000000000000000000001057 153.0
HKD2_k127_5891832_0 Aconitase C-terminal domain K01703 - 4.2.1.33,4.2.1.35 4.436e-262 818.0
HKD2_k127_5891832_1 Involved in the tonB-independent uptake of proteins - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001498 423.0
HKD2_k127_589751_0 PAS domain - - - 0.000000000000000000000000008923 121.0
HKD2_k127_589751_1 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively K01243 - 3.2.2.9 0.0000003691 61.0
HKD2_k127_5901304_0 COG1333 ResB protein required for cytochrome c biosynthesis K07399 - - 0.00001035 58.0
HKD2_k127_5902104_0 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) K01925 - 6.3.2.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001496 371.0
HKD2_k127_5902104_1 Phospho-N-acetylmuramoyl-pentapeptide-transferase signature 1 K01000 - 2.7.8.13 0.0000000000000000000000000000000000000002159 151.0
HKD2_k127_5902104_2 Belongs to the SEDS family K03588 - - 0.00000000000000000000000000000000004542 154.0
HKD2_k127_5903926_0 Phenazine biosynthesis-like protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000007425 289.0
HKD2_k127_5903926_1 Peptidase family M50 - - - 0.0000000000000000000000000000000000000102 151.0
HKD2_k127_5914814_0 Glycosyl hydrolase 36 superfamily, catalytic domain K00702,K13688 - 2.4.1.20 1.992e-316 979.0
HKD2_k127_5921185_0 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate K00620 - 2.3.1.1,2.3.1.35 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001162 338.0
HKD2_k127_5921185_1 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003283 253.0
HKD2_k127_5923661_0 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates K01937 - 6.3.4.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002015 390.0
HKD2_k127_5923661_1 Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria K00979 - 2.7.7.38 0.00000000000000000000000000000000000000000000000000000131 198.0
HKD2_k127_5930293_0 Metallo-beta-lactamase superfamily K02238 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001004 286.0
HKD2_k127_5949942_0 Amidohydrolase K07045 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001755 262.0
HKD2_k127_5949942_1 bifunctional purine biosynthesis protein purh K00602 GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 0.00000000000000000000000000000000000000000000001122 174.0
HKD2_k127_5952590_0 Acetyl-coenzyme A transporter 1 K08218 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001676 504.0
HKD2_k127_5952590_1 DNA-templated transcription, initiation K03088 - - 0.0002844 47.0
HKD2_k127_5952697_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004622 516.0
HKD2_k127_5952697_1 Short-chain dehydrogenase reductase SDR K00059 - 1.1.1.100 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001282 349.0
HKD2_k127_5952697_2 COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - 0.000000000000000000001607 100.0
HKD2_k127_5952697_3 Carboxypeptidase regulatory-like domain - - - 0.0000000000004742 77.0
HKD2_k127_5952697_4 Carboxypeptidase regulatory-like domain - - - 0.0000002539 60.0
HKD2_k127_5965651_0 Signal transduction histidine kinase - - - 0.00000000000000000004959 102.0
HKD2_k127_5965651_1 deoxyhypusine monooxygenase activity - - - 0.0000000000000000007285 101.0
HKD2_k127_5967340_0 DNA-binding transcription factor activity - - - 0.000000000000000000000009343 105.0
HKD2_k127_5967340_1 Outer membrane efflux protein - - - 0.00000004854 65.0
HKD2_k127_5990577_0 homoserine kinase activity K00823,K07250 - 2.6.1.19,2.6.1.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005064 536.0
HKD2_k127_5990577_1 - - - - 0.000000000001783 80.0
HKD2_k127_5990577_2 YceI-like domain - - - 0.00000000009607 71.0
HKD2_k127_5990577_3 Rieske 2Fe-2S K16937 - 1.8.5.2 0.000000002859 66.0
HKD2_k127_5992842_0 diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003646 277.0
HKD2_k127_5992842_1 Acetyltransferase (GNAT) domain - - - 0.0000000000004942 73.0
HKD2_k127_5992842_2 - - - - 0.0004732 49.0
HKD2_k127_6001970_0 Peptidase MA superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000003862 253.0
HKD2_k127_6001970_1 nuclear chromosome segregation - - - 0.00006551 49.0
HKD2_k127_6006448_0 PFAM Alcohol dehydrogenase K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008333 402.0
HKD2_k127_6006448_1 PFAM Alcohol dehydrogenase K00008 - 1.1.1.14 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003566 358.0
HKD2_k127_6006448_2 Proline dehydrogenase K00318 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000208 259.0
HKD2_k127_6006448_3 metal-dependent phosphohydrolase HD region - - - 0.0000000000000000000000000000000000000000000009026 185.0
HKD2_k127_6007192_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K03296,K18138 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008674 466.0
HKD2_k127_6007192_1 PFAM Chlorite dismutase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003776 260.0
HKD2_k127_6007192_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585,K07799 - - 0.000000000000000000000000000000000000000000000000000000000000001056 232.0
HKD2_k127_6009342_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01883 - 6.1.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004691 443.0
HKD2_k127_6009342_1 Belongs to the glycosyl hydrolase 26 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003794 404.0
HKD2_k127_6009342_2 Belongs to the peptidase S41A family K03797 - 3.4.21.102 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 383.0
HKD2_k127_6009342_3 Sigma factor PP2C-like phosphatases K07315 - 3.1.3.3 0.0000000000000000000000000000000000000000000000000000002182 205.0
HKD2_k127_6009342_4 PFAM SNARE associated Golgi protein - - - 0.0000000000000000000001547 105.0
HKD2_k127_6009342_5 Belongs to the UPF0102 family K07460 - - 0.0000000000000000001412 101.0
HKD2_k127_6011186_0 Peptidase S10 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003902 477.0
HKD2_k127_6011625_0 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA K04066 GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002642 466.0
HKD2_k127_6011625_1 Peptidase family M50 - - - 0.00000000000000000000000000000000000000000000000000000001361 208.0
HKD2_k127_6016095_0 amino acid K03294 - - 2.282e-223 703.0
HKD2_k127_6020160_0 PFAM GGDEF domain containing protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003294 336.0
HKD2_k127_6020160_1 Histidine kinase K11527 - 2.7.13.3 0.000000000000000000000000000004004 130.0
HKD2_k127_6020160_2 Putative regulatory protein - - - 0.0000261 56.0
HKD2_k127_6040604_0 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit K06949 - 3.1.3.100 0.0000000000000001253 81.0
HKD2_k127_6048960_0 PFAM SMP-30 Gluconolaconase - - - 0.000000000000000000000000000000000000000000002542 175.0
HKD2_k127_6048960_1 Glyoxalase-like domain K06996 - - 0.0000000000000000000000000000000000003361 153.0
HKD2_k127_6051407_0 Permease, YjgP YjgQ - - - 0.0000000000000000000000000000000000000000000000000000000000000000015 238.0
HKD2_k127_6051407_1 Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily K03976 - - 0.0000000000000000000000000000000000000000000000000000000000000002669 235.0
HKD2_k127_6051407_2 GtrA-like protein K00995 - 2.7.8.5 0.000000000000000000000000000000000007887 145.0
HKD2_k127_6060411_0 amino acid - - - 1.645e-214 672.0
HKD2_k127_6075570_0 exoribonuclease II activity K01147,K12573 - 3.1.13.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000485 488.0
HKD2_k127_6077565_0 Y_Y_Y domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000009755 292.0
HKD2_k127_6077565_1 response regulator, receiver K00384,K07315 - 1.8.1.9,3.1.3.3 0.0000000000000000000000000000000000000000000000000000000000000000000001526 248.0
HKD2_k127_6078532_0 Cyclic nucleotide-monophosphate binding domain K03301 - - 0.000000000000000000000000000000000000000000005606 181.0
HKD2_k127_6078532_1 nuclease subunit A K16898 - 3.6.4.12 0.0000000000001232 73.0
HKD2_k127_6091607_0 Methylmalonyl-CoA mutase K01848 - 5.4.99.2 1.389e-222 702.0
HKD2_k127_6091607_1 PFAM glycosyl transferase group 1 K15521 - 2.4.1.250 0.00002182 49.0
HKD2_k127_6092887_0 Protein kinase domain K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000005668 195.0
HKD2_k127_6092887_1 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - 0.0000000000000002436 86.0
HKD2_k127_6092887_2 - - - - 0.000000007047 67.0
HKD2_k127_6093175_0 Glycoside hydrolase family 44 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000049 365.0
HKD2_k127_6093175_1 Peptidase family M1 domain - - - 0.00000000000000000000000000000000000000000000000002169 185.0
HKD2_k127_6098596_0 Belongs to the DegT DnrJ EryC1 family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000005758 287.0
HKD2_k127_6098596_1 FG-GAP repeat - - - 0.00000000000000000000000522 108.0
HKD2_k127_6130778_0 PFAM cytochrome bd ubiquinol oxidase subunit II K00426 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005282 349.0
HKD2_k127_6130778_1 Belongs to the transferase hexapeptide repeat family K00674 - 2.3.1.117 0.000000000000000000000000000000000000000000000000000000000000000000000000000000008714 273.0
HKD2_k127_6130778_2 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.00000000000000000000000000005561 118.0
HKD2_k127_6164817_0 Stage II sporulation protein K06381 - - 0.000000000000000000000000000000000008085 152.0
HKD2_k127_6164817_1 Domain of unknown function (DUF4388) - - - 0.0000000000000000000000003637 115.0
HKD2_k127_6179194_0 Pseudouridine synthase K06175 - 5.4.99.26 0.00000000000000000000000000000000000000000000000000000000000001273 233.0
HKD2_k127_6179194_1 SMART Elongator protein 3 MiaB NifB - - - 0.00000000000000000000000000000004797 132.0
HKD2_k127_6179194_2 membrane protein (homolog of Drosophila rhomboid) - - - 0.000000000000000000001281 106.0
HKD2_k127_6194286_0 cyclic diguanylate phosphodiesterase - - - 0.0000000000000000000000000000000000000000000005736 177.0
HKD2_k127_6194286_1 PFAM Cold-shock K03704 - - 0.00000000000000000000000002602 111.0
HKD2_k127_6194286_2 Glycine-rich RNA-binding protein - - - 0.000000000000000000002036 100.0
HKD2_k127_6197075_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 4.469e-258 808.0
HKD2_k127_6206379_0 Iron-sulfur cluster-binding domain K22227 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000115 370.0
HKD2_k127_6206379_1 ResB-like family - - - 0.0000000000000000002429 96.0
HKD2_k127_6206379_2 histidine kinase, dimerisation and phosphoacceptor region K02486 - 2.7.13.3 0.00003055 53.0
HKD2_k127_6230554_0 TIGRFAM drug resistance transporter, EmrB QacA subfamily K03446 - - 6.376e-212 671.0
HKD2_k127_6230554_1 Biotin-lipoyl like K03543 - - 0.0000000000000000000000000000000000000000000000000000000000000000005383 235.0
HKD2_k127_6230554_2 Belongs to the glycosyl hydrolase 2 family K01190 - 3.2.1.23 0.0000000000000000000000000001911 133.0
HKD2_k127_6246768_0 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism K03595 - - 0.00000000000000000000000000000000000000000000000000000000000000002715 230.0
HKD2_k127_6250289_0 Glycosyl transferase, family 2 K00721 - 2.4.1.83 0.00000000000000000000000000000000000000000000000000000000000000000000000000000002583 275.0
HKD2_k127_6250289_1 Methyltransferase domain K00568 - 2.1.1.222,2.1.1.64 0.00000000000000000000000000000000000000000000001758 187.0
HKD2_k127_6250289_2 hopanoid biosynthesis associated protein HpnK - - - 0.0000000000000000000000000000000000005429 156.0
HKD2_k127_6250289_3 PFAM Peptidase M16 inactive domain K07263 - - 0.000000000000000000005536 98.0
HKD2_k127_6285474_0 Salt-induced outer membrane protein K07283 - - 0.0000000002473 70.0
HKD2_k127_6285474_1 META domain K03668 - - 0.0006907 48.0
HKD2_k127_6292127_0 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively K06215 - 4.3.3.6 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001958 335.0
HKD2_k127_6292127_1 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000007951 224.0
HKD2_k127_6307249_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005683 307.0
HKD2_k127_6307249_1 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000141 156.0
HKD2_k127_6307249_2 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body K02988 - - 0.000000000000000000000000000000000001948 139.0
HKD2_k127_6307249_3 Ribosomal protein L30 K02907 - - 0.000000000008322 71.0
HKD2_k127_630804_0 transferase activity, transferring glycosyl groups - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 333.0
HKD2_k127_630804_1 (ABC) transporter K06147 - - 0.0000000000000000000000000000000000000000000314 164.0
HKD2_k127_630804_2 polysaccharide catabolic process K03478 - 3.5.1.105 0.00000000000000000000000000000000000003805 164.0
HKD2_k127_630804_3 arylsulfatase activity - - - 0.00000002081 63.0
HKD2_k127_6332001_0 Calcineurin-like phosphoesterase superfamily domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000002141 242.0
HKD2_k127_6332001_1 DTW - - - 0.000000000000000000000000000000001111 148.0
HKD2_k127_6332001_2 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate K00891 - 2.7.1.71 0.0000000000000000000000000001178 125.0
HKD2_k127_6332001_3 Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate K00800 GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 0.000000000000000000000000105 108.0
HKD2_k127_6332001_4 Calcineurin-like phosphoesterase - - - 0.0000000000009037 73.0
HKD2_k127_6335308_0 Peptidase dimerisation domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005954 469.0
HKD2_k127_6335308_1 Las17-binding protein actin regulator - - - 0.00000000000000000000000000000000000000000000000000008445 211.0
HKD2_k127_6335308_2 arylsulfatase activity - - - 0.0000000000000000000000000000000001229 144.0
HKD2_k127_6353844_0 Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system K02036 - 3.6.3.27 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002631 368.0
HKD2_k127_6353844_1 Plays a role in the regulation of phosphate uptake K02039 - - 0.0000000000000000000000000000000000000000000000000000000000000000003322 235.0
HKD2_k127_6353844_2 phosphate transport system permease K02038 - - 0.000007943 48.0
HKD2_k127_635412_0 TfuA-like protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000003858 263.0
HKD2_k127_635412_1 cytochrome P450 - - - 0.000000000000000000000000000000000000000000000000000000000001019 214.0
HKD2_k127_635412_2 O-methyltransferase - - - 0.000000000000000000000000000000000000000000000000000000000006541 221.0
HKD2_k127_6379978_0 PFAM NHL repeat containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002983 325.0
HKD2_k127_639361_1 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.0000000000000000000007449 109.0
HKD2_k127_6396953_0 Putative peptidoglycan binding domain K21470 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000001318 269.0
HKD2_k127_6402004_0 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001143 328.0
HKD2_k127_6402004_1 Diacylglycerol kinase catalytic domain K07029 GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.107 0.000000000000000000008825 105.0
HKD2_k127_6429649_0 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans K00975 - 2.7.7.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006714 481.0
HKD2_k127_6429649_1 PFAM KDPG and KHG aldolase K01625 - 4.1.2.14,4.1.3.42 0.000000000000000000000000000000001476 138.0
HKD2_k127_6429649_2 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis K01689 - 4.2.1.11 0.000000000000000000007998 93.0
HKD2_k127_6429649_3 Carboxypeptidase regulatory-like domain - - - 0.00009042 53.0
HKD2_k127_6433252_0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000149 391.0
HKD2_k127_6433252_1 lipolytic protein G-D-S-L family - - - 0.000004084 56.0
HKD2_k127_643983_0 ABC transporter - - - 3.111e-224 707.0
HKD2_k127_643983_1 Sortilin, neurotensin receptor 3, - - - 0.000000001794 64.0
HKD2_k127_6447812_0 TRAP transporter T-component - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002149 383.0
HKD2_k127_6447812_1 Vacuole effluxer Atg22 like K06902 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001465 287.0
HKD2_k127_6447812_2 PFAM TRAP dicarboxylate transporter- DctP subunit - - - 0.00000000000000000000000000000000000000000000000000000000001792 224.0
HKD2_k127_6454062_0 ERAP1-like C-terminal domain K01256,K01263 - 3.4.11.14,3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000001287 300.0
HKD2_k127_6459615_0 NADH dehydrogenase (ubiquinone) activity K14089 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000231 261.0
HKD2_k127_6459615_1 NADH ubiquinone oxidoreductase, 20 Kd subunit - - - 0.0000000000000000000000000000000000000000000000000000000000000000000001035 248.0
HKD2_k127_6459615_2 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000000000000002026 216.0
HKD2_k127_6459615_3 - - - - 0.00000000000000000000000000000000000000000000000001128 188.0
HKD2_k127_6460106_0 MASE1 - - - 0.0000000000000000000000000000000000000000000005789 175.0
HKD2_k127_6460106_1 Cupin 2, conserved barrel domain protein - - - 0.0000000000001682 75.0
HKD2_k127_6460106_2 lactoylglutathione lyase activity - - - 0.00000003423 62.0
HKD2_k127_6464734_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337,K05572 GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002409 343.0
HKD2_k127_6464734_1 PFAM NADH-ubiquinone plastoquinone oxidoreductase, chain 6 K00339 - 1.6.5.3 0.0000000000000000000000000000000000007483 144.0
HKD2_k127_6464734_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00338,K03615,K05580 - 1.6.5.3 0.00000000000000000000000000000000002095 154.0
HKD2_k127_6464734_3 ATP synthesis coupled electron transport K00340,K05576 - 1.6.5.3 0.0000000000000000000000001253 116.0
HKD2_k127_6467042_0 Belongs to the GARS family K01945,K01952,K13713 - 6.3.2.6,6.3.4.13,6.3.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002102 374.0
HKD2_k127_6467042_1 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA K07056 GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:1901360 2.1.1.198 0.00006142 47.0
HKD2_k127_6467042_2 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - 0.0002419 54.0
HKD2_k127_6467042_3 - - - - 0.0002646 46.0
HKD2_k127_646853_0 4-alpha-glucanotransferase K00705,K06044 - 2.4.1.25,5.4.99.15 2.81e-219 693.0
HKD2_k127_648192_0 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000003436 203.0
HKD2_k127_6493547_0 PFAM Peptidase M1, membrane alanine aminopeptidase K01256 - 3.4.11.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007423 314.0
HKD2_k127_6532976_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K02005 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000002927 302.0
HKD2_k127_6532976_1 outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000001303 217.0
HKD2_k127_6532976_2 Carboxypeptidase regulatory-like domain - - - 0.000000001205 67.0
HKD2_k127_6534325_0 Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) K00773 - 2.4.2.29 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003164 440.0
HKD2_k127_6534325_1 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03072,K12257 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001086 418.0
HKD2_k127_6534325_2 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA K03074 - - 0.00000000000000000000000000000000000000000000000000000000000000000000001025 253.0
HKD2_k127_6534325_3 Belongs to the D-alanine--D-alanine ligase family K01921 - 6.3.2.4 0.0000000000000000000000000000000000008674 144.0
HKD2_k127_6534325_4 The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF- YajC-YidC subcomplex facilitates these functions K03210 - - 0.000000008018 62.0
HKD2_k127_6559056_0 GDSL-like Lipase/Acylhydrolase family - - - 0.000000000000000002299 98.0
HKD2_k127_6559056_1 manganese ion transmembrane transporter activity - - - 0.0000000619 61.0
HKD2_k127_6561036_0 Acyl-CoA dehydrogenase, C-terminal domain K16173 - 1.3.99.32 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 465.0
HKD2_k127_6561036_1 Bacterial fructose-1,6-bisphosphatase, glpX-encoded K02446 - 3.1.3.11 0.000000000000000000000000000000000000000000000000000000000000000001686 246.0
HKD2_k127_6565769_0 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002962 393.0
HKD2_k127_6565769_1 Carbon-nitrogen hydrolase K03820 - - 0.000000000000000000000000000000000000001843 152.0
HKD2_k127_6565769_2 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA K02836 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - 0.0000000001802 63.0
HKD2_k127_6567177_0 PFAM BNR Asp-box repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004863 318.0
HKD2_k127_6572083_0 Sulfite exporter TauE/SafE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003292 312.0
HKD2_k127_6572083_1 Transcriptional regulator - - - 0.000000000000000000000000000000000000000000000000000000000000001993 226.0
HKD2_k127_6572083_2 Belongs to the proline racemase family K01777,K12658 - 5.1.1.4,5.1.1.8 0.000000000000000000000000000000000000000000000000000000000000001997 224.0
HKD2_k127_6572083_3 Transcriptional regulator sugar kinase K00886 - 2.7.1.63 0.00000000000000000000000000000000000000000000000000000002847 199.0
HKD2_k127_6587409_0 PFAM Type II secretion system protein E K02652 - - 3.958e-203 640.0
HKD2_k127_6587409_1 Pilus assembly protein K02662 - - 0.0000000000000003112 93.0
HKD2_k127_6612500_0 Histidine kinase-, DNA gyrase B-, and HSP90-like - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009082 326.0
HKD2_k127_6612500_1 Response regulator receiver - - - 0.000000000000000000000000000000000000000000000000000000003421 203.0
HKD2_k127_6612500_2 polysaccharide export K01991 - - 0.0000000000000000001896 93.0
HKD2_k127_6612500_3 PFAM Polysaccharide export protein K01991 - - 0.0000000000000007543 83.0
HKD2_k127_6612500_4 GGDEF domain K01768 - 4.6.1.1 0.000000000000017 78.0
HKD2_k127_661347_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000113 436.0
HKD2_k127_661347_1 Biotin-lipoyl like K02005 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000006914 254.0
HKD2_k127_661347_2 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000003415 114.0
HKD2_k127_6613500_0 PFAM Serine threonine-protein kinase-like domain K12132 - 2.7.11.1 0.0000000000000000000000000000000000000000000000000000007097 199.0
HKD2_k127_6613500_1 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K01838 - 5.4.2.6 0.00000000000000000000000000000000000000001307 162.0
HKD2_k127_6613500_2 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000009402 106.0
HKD2_k127_6613972_0 Protein kinase domain K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000009666 274.0
HKD2_k127_6613972_1 Diguanylate cyclase - - - 0.00000000000000000000000008732 110.0
HKD2_k127_6614661_0 With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD K10979 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002543 321.0
HKD2_k127_6614661_1 Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000001291 231.0
HKD2_k127_6614661_2 Protein of unknown function DUF72 - - - 0.0000002778 52.0
HKD2_k127_6624849_0 Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - 0.00000000000000000000000005353 119.0
HKD2_k127_6624849_1 Circadian clock protein KaiC K08482 - - 0.0000000005742 69.0
HKD2_k127_6627661_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06131 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001177 476.0
HKD2_k127_6627661_1 Alternative locus ID K01802,K03772 - 5.2.1.8 0.00000000000000004371 81.0
HKD2_k127_6627661_2 Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins K03832 - - 0.000003124 57.0
HKD2_k127_6634272_0 GatB/GatE catalytic domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005185 450.0
HKD2_k127_6634272_1 TIGRFAM drug resistance transporter, EmrB QacA subfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000004861 273.0
HKD2_k127_6636334_0 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis K03525 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.1.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003627 307.0
HKD2_k127_6636334_1 Biotin/lipoate A/B protein ligase family K03524 - 6.3.4.15 0.0000000000000000000000000000003519 132.0
HKD2_k127_6636673_0 - - - - 0.0000000000002177 83.0
HKD2_k127_6641865_0 Metal dependent phosphohydrolases with conserved 'HD' motif. - - - 0.000000000000000000000000000000000000000000000000000000000000009262 221.0
HKD2_k127_6641865_1 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.0000000000000000000000000000000000000000000000000001017 191.0
HKD2_k127_6641865_2 Y_Y_Y domain - - - 0.000000000000000000000000000000001777 143.0
HKD2_k127_6641970_0 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008007 315.0
HKD2_k127_6647645_0 Outer membrane efflux protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000006883 271.0
HKD2_k127_6647645_1 Belongs to the DNA glycosylase MPG family K03652 - 3.2.2.21 0.000000000000000000000000000000000000000008002 156.0
HKD2_k127_6648000_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000616 396.0
HKD2_k127_6650121_0 PFAM membrane protein involved in aromatic hydrocarbon degradation K06076 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001384 378.0
HKD2_k127_6650121_1 cystathionine gamma-synthase activity K01739,K01761 - 2.5.1.48,4.4.1.11 0.0000000000000000000000000000000000000000000000000000000002615 207.0
HKD2_k127_6656120_0 Dolichyl-phosphate-mannose-protein mannosyltransferase - - - 0.000002614 59.0
HKD2_k127_6701529_0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction K01409 GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004208 347.0
HKD2_k127_6701529_1 MOFRL family K11529 - 2.7.1.165 0.000000000000000000000000000000000000000000000000000000000000000005622 238.0
HKD2_k127_6701529_2 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) K08963 - 5.3.1.23 0.00000000000000000000000000000000008451 134.0
HKD2_k127_6713011_0 Amino acid kinase family K00926 - 2.7.2.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006312 336.0
HKD2_k127_6713011_1 Isocitrate/isopropylmalate dehydrogenase K00052 - 1.1.1.85 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001122 322.0
HKD2_k127_6715225_0 Inward rectifier potassium channel K08715 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000003248 299.0
HKD2_k127_6715225_1 Sigma factor PP2C-like phosphatases - - - 0.000000000000000000000000000000000000000000000000000000000000000002017 236.0
HKD2_k127_6715225_2 SelR domain K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000001839 205.0
HKD2_k127_6715225_3 PFAM PBS lyase HEAT-like repeat - - - 0.000000000000000006494 95.0
HKD2_k127_6715225_4 AI-2E family transporter - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - 0.0000000000000005953 89.0
HKD2_k127_6731376_0 K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - 0.0000000000000000000000000000000000002472 144.0
HKD2_k127_6731376_1 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000001618 82.0
HKD2_k127_6731376_2 - - - - 0.00000000000001074 85.0
HKD2_k127_674724_0 transcriptional - - - 0.000000000000000000000000000000000000000000000000000000000000000000000002496 253.0
HKD2_k127_674724_1 protein kinase activity K12132 - 2.7.11.1 0.0000000002799 64.0
HKD2_k127_674724_2 - - - - 0.0000001343 59.0
HKD2_k127_6767264_0 Acetyl propionyl-CoA carboxylase, alpha subunit K01965,K01968 - 6.4.1.3,6.4.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001964 454.0
HKD2_k127_6767264_1 Beta-lactamase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001916 273.0
HKD2_k127_6772016_0 that it carries out the mismatch recognition step. This protein has a weak ATPase activity K03555 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 2.353e-251 802.0
HKD2_k127_6772016_1 Universal bacterial protein YeaZ K14742 - - 0.0000000000000004892 80.0
HKD2_k127_6786669_0 PFAM tRNA synthetase, class II (G, H, P and S) K01892 - 6.1.1.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003091 419.0
HKD2_k127_6786669_1 Bacterial transferase hexapeptide (six repeats) - - - 0.00000000000000000000000000000000000000000000000000000004369 212.0
HKD2_k127_6786669_2 Cytidine and deoxycytidylate deaminase zinc-binding region - - - 0.000000000000008611 83.0
HKD2_k127_6786908_0 response regulator, receiver K01120 - 3.1.4.17 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002282 443.0
HKD2_k127_6786908_1 Glycerophosphoryl diester phosphodiesterase family K01126 - 3.1.4.46 0.00000000000000000000000000000000003226 154.0
HKD2_k127_6792976_0 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex K02519 - - 5.265e-231 732.0
HKD2_k127_6792976_1 Protein of unknown function (DUF503) K09764 - - 0.0000000000000006957 84.0
HKD2_k127_6794107_0 Belongs to the 'phage' integrase family K04763 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000009867 291.0
HKD2_k127_6794107_1 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme K00789 GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 0.0000000000000000001971 88.0
HKD2_k127_6808157_0 (ABC) transporter K15738 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000009122 288.0
HKD2_k127_6808157_1 Bacterial membrane protein, YfhO - - - 0.00000000005226 76.0
HKD2_k127_6820516_0 Peptidase dimerisation domain K01295 - 3.4.17.11 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008385 404.0
HKD2_k127_6820516_1 Endonuclease/Exonuclease/phosphatase family K01142 - 3.1.11.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001262 338.0
HKD2_k127_6820516_2 Belongs to the MsrB Met sulfoxide reductase family K07305 - 1.8.4.12 0.00000000000000000000000000000000000000000000000000000001012 207.0
HKD2_k127_6824962_0 PFAM carboxyl transferase K15052 - 2.1.3.15,6.4.1.3 3.922e-225 710.0
HKD2_k127_6824962_1 Peptidase family M28 - - - 0.00000000000000000000000009263 108.0
HKD2_k127_6836598_0 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs K12573 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001487 467.0
HKD2_k127_6849358_0 Belongs to the beta-ketoacyl-ACP synthases family - - - 2.932e-307 958.0
HKD2_k127_685488_0 response regulator - - - 0.00000000000000000000000000000000000000000000000000000000000000000000007001 252.0
HKD2_k127_685488_1 HAMP domain K02482 - 2.7.13.3 0.00000000000000000000000000000000000000000000000000000000000000008964 227.0
HKD2_k127_685488_2 Peptidase family M54 K06974 - - 0.0000000000000000000000000000000000000000000001663 177.0
HKD2_k127_6873512_0 Aminotransferase K00812 - 2.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003988 506.0
HKD2_k127_6873512_1 amine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001472 297.0
HKD2_k127_6882075_0 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) K00969,K01488 GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.5.4.4 0.00000000000000000000000000000000000001131 155.0
HKD2_k127_6882075_1 Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation K09710 - - 0.0000000000000000000002871 101.0
HKD2_k127_6882075_2 COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - 0.00000000000000000001267 99.0
HKD2_k127_6882075_3 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000001 74.0
HKD2_k127_6885919_0 AlkA N-terminal domain K13529,K13530 - 3.2.2.21 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003762 459.0
HKD2_k127_6885919_1 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated K00567 GO:0003674,GO:0003824,GO:0003908,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 2.1.1.63 0.00000000000000000001341 107.0
HKD2_k127_6896634_0 RnfC Barrel sandwich hybrid domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001627 322.0
HKD2_k127_6896634_1 Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction - - - 0.0000000000000000000000000000000000000000000000000000000000000000000004225 248.0
HKD2_k127_6896634_2 RNA polymerase recycling family C-terminal K03580 - - 0.00000000000000000000000000000000000001382 157.0
HKD2_k127_689694_0 Glucose-1-phosphate cytidylyltransferase K00978 - 2.7.7.33 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004457 312.0
HKD2_k127_689694_1 Polysaccharide biosynthesis protein K01709 - 4.2.1.45 0.0000000000000000000000004161 121.0
HKD2_k127_689694_2 Glycosyl transferases group 1 - - - 0.000000000000000006481 96.0
HKD2_k127_6902917_0 Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000007331 289.0
HKD2_k127_6902917_1 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000007271 289.0
HKD2_k127_6914706_0 bacteriocin biosynthesis docking scaffold, SagD family K09136 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001101 524.0
HKD2_k127_6914706_1 Nitroreductase family - - - 0.000000000000000000003463 109.0
HKD2_k127_6920114_0 Cell shape determining protein MreB Mrl - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003084 322.0
HKD2_k127_6920114_1 N-Acetylmuramoyl-L-alanine amidase K11066,K12287 - 3.5.1.28 0.000001096 54.0
HKD2_k127_6920749_0 Pfam Uncharacterised protein family UPF0047 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 364.0
HKD2_k127_6920749_1 Cys/Met metabolism PLP-dependent enzyme K01739,K01760,K01761 - 2.5.1.48,4.4.1.11,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000003681 237.0
HKD2_k127_6920749_2 Diguanylate cyclase - - - 0.00000000000000000000000004012 109.0
HKD2_k127_6932623_0 Methylenetetrahydrofolate reductase K00297,K00547,K00548 - 1.5.1.20,2.1.1.10,2.1.1.13 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001288 484.0
HKD2_k127_6932623_1 TIGRFAM VWFA-related Acidobacterial domain - - - 0.00000000000000000000001499 113.0
HKD2_k127_6932623_2 - - - - 0.000000000000000000007041 98.0
HKD2_k127_6944147_0 Tetratricopeptide repeat - - - 0.0000000000000000000000000000000000000000000000000001636 207.0
HKD2_k127_6944147_1 SMART Tetratricopeptide domain protein - - - 0.0000000000000000001402 104.0
HKD2_k127_6950666_0 - - - - 0.0000000000000000000000000000000000000000000000000000135 203.0
HKD2_k127_6950666_1 lysine biosynthetic process via aminoadipic acid - - - 0.000000000000000000000000000000000000002799 162.0
HKD2_k127_6951286_0 Adenylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000009183 223.0
HKD2_k127_6951286_1 - - - - 0.0000000000000000000001778 104.0
HKD2_k127_6956307_0 PFAM Molybdopterin dehydrogenase, FAD-binding K11178 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001528 334.0
HKD2_k127_6956307_1 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K11177 - 1.17.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003403 323.0
HKD2_k127_6970708_0 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids K00648 - 2.3.1.180 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001299 357.0
HKD2_k127_6970708_1 Belongs to the FPG family K05522 - 4.2.99.18 0.00000000000000000000000000001791 124.0
HKD2_k127_6972057_0 Putative zinc binding domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001342 340.0
HKD2_k127_6972057_1 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 - 5.1.3.13 0.000000000000000000000000000000000000000000000000004996 199.0
HKD2_k127_6972057_2 polysaccharide biosynthetic process - - - 0.0000000000000000000000008237 119.0
HKD2_k127_6987155_0 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine K00797 - 2.5.1.16 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000159 328.0
HKD2_k127_6987155_1 Amidase - - - 0.0005191 53.0
HKD2_k127_6987704_0 - - - - 0.00000002344 64.0
HKD2_k127_6987704_1 Class III cytochrome C family - - - 0.000003314 61.0
HKD2_k127_6995080_0 glutamate dehydrogenase [NAD(P)+] activity K00262 - 1.4.1.4 4.6e-253 792.0
HKD2_k127_6995080_1 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate K00615 - 2.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006456 363.0
HKD2_k127_6996584_0 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids K00806 - 2.5.1.31 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000004601 301.0
HKD2_k127_6996584_1 PFAM Glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000001563 218.0
HKD2_k127_6996584_2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) K00762 - 2.4.2.10 0.00000000000000000000000000000000000000000000000000000000719 205.0
HKD2_k127_6996584_3 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs K06173 - 5.4.99.12 0.00000000000000000000000000000000000000000000005081 181.0
HKD2_k127_6996584_4 PFAM Glycosyl transferase, group 1 - - - 0.0000002216 63.0
HKD2_k127_7002966_0 FHA domain K07315 - 3.1.3.3 0.0000000000000000000000000000001485 136.0
HKD2_k127_7002966_1 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000005391 94.0
HKD2_k127_7002966_2 Tetratricopeptide repeat - - - 0.00002406 56.0
HKD2_k127_7020994_0 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol K06132 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000003256 294.0
HKD2_k127_7020994_1 Alpha/beta hydrolase family - - - 0.000000000000000000000000000000000234 147.0
HKD2_k127_7023534_0 Glycosyl transferase, family 2 - - - 0.0000000227 66.0
HKD2_k127_7023534_1 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine K01733 - 4.2.3.1 0.00006381 46.0
HKD2_k127_7044303_0 Transketolase, pyrimidine binding domain K00162 - 1.2.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000208 408.0
HKD2_k127_7044303_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381 - 1.2.4.1,1.2.4.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001615 371.0
HKD2_k127_7044303_2 2-oxoacid dehydrogenases acyltransferase (catalytic domain) K00162,K00627 - 1.2.4.1,2.3.1.12 0.0000000000000000000002995 98.0
HKD2_k127_7062662_0 Tetratricopeptide repeat - - - 0.00000000000000000000000000000000000000000000000000000000000000003168 239.0
HKD2_k127_7062662_1 GDSL-like Lipase/Acylhydrolase - - - 0.0000000000000001674 93.0
HKD2_k127_7065827_0 Protein of unknown function (DUF1343) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004806 429.0
HKD2_k127_7065827_1 Carboxypeptidase regulatory-like domain - - - 0.0000000000000000000000000000000000000000000000000000000000000002146 233.0
HKD2_k127_7065827_2 EamA-like transporter family - - - 0.0000000000000000000000000000000000000000000000000000000000002903 229.0
HKD2_k127_7065827_3 diguanylate cyclase - - - 0.00000000000000000000000000000000000000001023 169.0
HKD2_k127_7065827_4 AsnC family - - - 0.000000000000000003237 93.0
HKD2_k127_7065827_5 - - - - 0.0004054 48.0
HKD2_k127_7104392_0 quinone binding K00337 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003251 415.0
HKD2_k127_7104392_1 Respiratory-chain NADH dehydrogenase, 49 Kd subunit K14090 - - 0.000000000000000000000000000000000000000000000000000000000000000000002289 238.0
HKD2_k127_7104392_2 4Fe-4S binding domain K14091 - - 0.0000000000000000000000000000000000000004674 152.0
HKD2_k127_7104392_3 spore germination K00442,K08315 - 3.4.23.51 0.000000000000000000000003655 113.0
HKD2_k127_7104542_0 PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002472 343.0
HKD2_k127_7104542_1 Belongs to the enoyl-CoA hydratase isomerase family K01715 - 4.2.1.17 0.00000000000000000000000000000000000000000000000000000000000000000000005323 250.0
HKD2_k127_7104542_2 Peptidase family M23 - - - 0.0000000000000000000000001922 109.0
HKD2_k127_7108076_0 Probably functions as a manganese efflux pump - - - 0.0000000000000000000000000000000000000000149 177.0
HKD2_k127_7110330_0 Response regulator receiver K07669,K07672 - - 0.000000000002912 76.0
HKD2_k127_7110330_1 SMART Tetratricopeptide repeat - - - 0.00000000003485 77.0
HKD2_k127_7124068_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 1.551e-207 656.0
HKD2_k127_7186761_0 UDP-N-acetylglucosamine 2-epimerase activity K01791,K18429 GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016787,GO:0016798,GO:0044238,GO:0071704,GO:1901576 3.2.1.184,5.1.3.14 0.0000000000000000000000000000000000000000000000000222 188.0
HKD2_k127_7186761_1 Domain of unknown function (DUF4388) - - - 0.000004603 53.0
HKD2_k127_7199969_0 Glycosyl transferase 4-like K00754 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006231 412.0
HKD2_k127_7199969_1 Bacillithiol biosynthesis BshC K22136 - - 0.0000000000000000000000000000000000000000000000000000001924 208.0
HKD2_k127_7221232_0 Formiminotransferase domain, N-terminal subdomain K13990 - 2.1.2.5,4.3.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002021 346.0
HKD2_k127_7221232_1 polysaccharide biosynthetic process - - - 0.0007665 52.0
HKD2_k127_7223673_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000001522 254.0
HKD2_k127_7223673_1 Belongs to the ompA family K03640 - - 0.0000000000000000000000000000007836 125.0
HKD2_k127_722627_0 Binding-protein-dependent transport system inner membrane component K02033 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003494 391.0
HKD2_k127_722627_1 COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components K02034 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000001038 297.0
HKD2_k127_7226325_0 [isocitrate dehydrogenase (NADP+)] phosphatase activity K00906 GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003969 539.0
HKD2_k127_7226325_1 D-isomer specific 2-hydroxyacid dehydrogenase K00058,K16843 - 1.1.1.310,1.1.1.399,1.1.1.95 0.00000000000000000000000166 108.0
HKD2_k127_724677_0 DegT/DnrJ/EryC1/StrS aminotransferase family K04127 - 5.1.1.17 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001699 528.0
HKD2_k127_724677_1 Belongs to the P(II) protein family K04751 - - 0.00000000000000000000000000000000000000000000000000000003427 198.0
HKD2_k127_724677_2 Ketopantoate reductase PanE/ApbA C terminal K00077 - 1.1.1.169 0.0000000000000002356 85.0
HKD2_k127_724677_3 Ammonium Transporter K03320 - - 0.0000002238 53.0
HKD2_k127_7247990_0 Cys/Met metabolism PLP-dependent enzyme K01739,K01758,K01760,K17217 - 2.5.1.48,4.4.1.1,4.4.1.2,4.4.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003623 450.0
HKD2_k127_7247990_1 Belongs to the cysteine synthase cystathionine beta- synthase family K01738 - 2.5.1.47 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001234 299.0
HKD2_k127_7247990_2 EVE domain - - - 0.000000000000000000000000000000000000000006581 158.0
HKD2_k127_7247990_3 protein involved in tolerance to divalent cations K03926 - - 0.000000000000000000000000005885 120.0
HKD2_k127_7249552_0 MacB-like periplasmic core domain K02004 - - 0.00000000000000000000000000000000000004067 149.0
HKD2_k127_7249552_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03767,K03768 - 5.2.1.8 0.0000000000000000000000000000000000003119 150.0
HKD2_k127_7249552_2 cell redox homeostasis - - - 0.0000000000000000000416 97.0
HKD2_k127_7249552_3 PFAM PfkB domain protein - - - 0.0000000000004144 71.0
HKD2_k127_7253167_0 PFAM amidinotransferase K01482 - 3.5.3.18 0.00000000000000000000000000000000000000000000000000000000000000000000003325 250.0
HKD2_k127_7253167_1 adenosine deaminase K01488 - 3.5.4.4 0.00000000000000000000000000000000000000000000003975 182.0
HKD2_k127_7253167_2 AhpC/TSA antioxidant enzyme - - - 0.000002282 55.0
HKD2_k127_7263854_0 Belongs to the peptidase S51 family K05995 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 3.4.13.21 0.0000000000000000000000000000000000000000000000000000000000000000000000000000003119 270.0
HKD2_k127_7263854_1 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000001651 206.0
HKD2_k127_7264059_0 OPT oligopeptide transporter protein - - - 2.001e-199 642.0
HKD2_k127_7266855_0 Major facilitator Superfamily - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000002648 291.0
HKD2_k127_7266855_1 Ndr family - - - 0.0000000000000000000000000000000000000000000000000000000003414 214.0
HKD2_k127_7266855_2 Belongs to the Glu Leu Phe Val dehydrogenases family K00263 - 1.4.1.9 0.0000000000000000000000000000000000000000003382 166.0
HKD2_k127_7276151_0 histidine kinase HAMP region domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001645 342.0
HKD2_k127_7276151_1 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009843 316.0
HKD2_k127_7276151_2 acid phosphatase activity - - - 0.000000000000000495 91.0
HKD2_k127_7284502_0 Enoyl-CoA hydratase/isomerase K01715,K13767 GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 4.2.1.17 0.000000000000000000000000000000000000000000000000000000000000004147 235.0
HKD2_k127_7284502_1 radical SAM domain protein K22318 - - 0.00000000000000000000003456 107.0
HKD2_k127_7295070_0 Myo-inositol-1-phosphate synthase K01858 - 5.5.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005898 587.0
HKD2_k127_7301069_0 Membrane dipeptidase (Peptidase family M19) K01273 - 3.4.13.19 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003123 284.0
HKD2_k127_7301069_1 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000005844 233.0
HKD2_k127_7304737_0 denitrification pathway - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002065 391.0
HKD2_k127_7304737_1 heat shock protein binding - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003077 379.0
HKD2_k127_7304737_2 Histidine kinase K07710,K10125 - 2.7.13.3 0.000000000000000000000000000000000000000000778 162.0
HKD2_k127_730570_0 Predicted Permease Membrane Region K07085 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000003954 270.0
HKD2_k127_730570_1 Cupin 2, conserved barrel domain protein K11477 - - 0.000000000000000001499 92.0
HKD2_k127_7316883_0 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00123 - 1.17.1.9 3.237e-295 921.0
HKD2_k127_7319781_0 Histidine kinase - - - 0.0000000000000000000000000000000000000000000000000001784 202.0
HKD2_k127_7319781_1 Large extracellular alpha-helical protein K06894 - - 0.0000000001698 70.0
HKD2_k127_7326366_0 FAD dependent oxidoreductase K00111 - 1.1.5.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001056 314.0
HKD2_k127_7326366_1 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.0001356 53.0
HKD2_k127_7331124_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008166 402.0
HKD2_k127_7331124_1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.000000000000000000000000000000000000000000000000000000000000000007435 248.0
HKD2_k127_7333066_0 ABC transporter K02065 - - 0.000000000000000000000000000000000000000000000000000000000001673 217.0
HKD2_k127_7333066_1 PFAM thioesterase superfamily - - - 0.0000000000000000000000000000000000000000000000000002772 187.0
HKD2_k127_7333066_2 ABC-type transport system involved in resistance to organic solvents permease component K02066 - - 0.000000000000000000000000000000000000000000003239 174.0
HKD2_k127_7346829_0 Belongs to the GSP D family K02453 - - 0.0000000000000000000000000000000000000000000000000000000000000000000005129 261.0
HKD2_k127_7346829_1 - - - - 0.0005787 45.0
HKD2_k127_7357504_0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain K01491 - 1.5.1.5,3.5.4.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001592 275.0
HKD2_k127_7357504_1 Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A K00859 GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 0.00000000000000000000000000000000000734 154.0
HKD2_k127_7364894_0 the current gene model (or a revised gene model) may contain a frame shift - - - 0.00001287 57.0
HKD2_k127_7366593_0 Nickel-dependent hydrogenase K14126 - 1.8.98.5 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002374 403.0
HKD2_k127_7366593_1 NADH ubiquinone oxidoreductase, 20 Kd subunit K14128 - 1.8.98.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001432 363.0
HKD2_k127_7366593_2 Malic enzyme, NAD binding domain K00027 - 1.1.1.38 0.000000000000000000000000000000000000000000000000000000000000000000000001306 249.0
HKD2_k127_7366593_3 PFAM methyl-viologen-reducing hydrogenase delta subunit K14127 - 1.8.98.5,1.8.98.6 0.0000000000000000000000000000000000000000000000000000000000003562 216.0
HKD2_k127_7366593_4 PFAM Nickel-dependent hydrogenase, large subunit K14126 - 1.8.98.5 0.0000000000000000000000000000000000002565 147.0
HKD2_k127_7366593_5 4Fe-4S ferredoxin iron-sulfur binding domain protein K03388 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 0.000000000562 63.0
HKD2_k127_7371565_0 Large extracellular alpha-helical protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001657 456.0
HKD2_k127_7374842_0 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000009495 237.0
HKD2_k127_7374842_1 Phosphotransferase enzyme family - - - 0.000000000000000000000000000000000000000000000004842 181.0
HKD2_k127_7382841_0 Enoyl-(Acyl carrier protein) reductase - - - 0.00000000000000000000000000000000000000000000000000000009908 201.0
HKD2_k127_7382841_1 cAMP biosynthetic process - - - 0.000000000000000000000000000000000000000000000000008544 192.0
HKD2_k127_7391226_0 Glutamine synthetase, beta-Grasp domain K01915 - 6.3.1.2 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001421 476.0
HKD2_k127_7407705_0 - - - - 0.0000000000000001246 85.0
HKD2_k127_7407705_1 Uncharacterised nucleotidyltransferase - - - 0.0009807 51.0
HKD2_k127_7420264_0 PFAM Hemerythrin HHE cation binding domain K09155 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007178 550.0
HKD2_k127_7420264_1 Uncharacterized conserved protein (DUF2249) - - - 0.00000000000000000004723 91.0
HKD2_k127_7420264_2 hemerythrin HHE cation binding domain - - - 0.00002705 47.0
HKD2_k127_7432897_0 ABC transporter substrate-binding protein K02035,K13889 - - 0.00000000000000000000000000000000000000003955 172.0
HKD2_k127_7433261_0 ABC transporter transmembrane region K06147,K18890 - - 0.00000000000000000000000000000000000000000000000000000000626 216.0
HKD2_k127_7433261_1 4-amino-4-deoxy-L-arabinose transferase activity - - - 0.000000000000000000000000000000000000000000000000002029 202.0
HKD2_k127_744199_0 Prolyl oligopeptidase family - - - 4.777e-207 653.0
HKD2_k127_7444200_0 PFAM glycosyl hydrolase BNR repeat-containing protein - - - 6.682e-198 630.0
HKD2_k127_7473476_0 DJ-1/PfpI family - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002306 274.0
HKD2_k127_7473476_1 Acyltransferase - - - 0.000000000000000000000000000000000000000000000000008077 190.0
HKD2_k127_7473476_2 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 - 0.00000000000000000004112 91.0
HKD2_k127_7475544_0 AMP-binding enzyme C-terminal domain K04110 - 6.2.1.25 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003021 351.0
HKD2_k127_7475544_1 Creatinine amidohydrolase K01470 - 3.5.2.10 0.00000000000000000000000000000000000000000002861 168.0
HKD2_k127_748615_0 cAMP biosynthetic process K01768 - 4.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002256 422.0
HKD2_k127_748615_1 radical SAM domain protein K22226 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001306 307.0
HKD2_k127_748615_2 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.0000000000000000000000000008928 121.0
HKD2_k127_748615_3 Leishmanolysin - - - 0.00003463 54.0
HKD2_k127_7492195_0 NAD(P)H dehydrogenase (quinone) activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000001349 268.0
HKD2_k127_7524631_0 ferredoxin oxidoreductase K00174 GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 2.016e-242 764.0
HKD2_k127_7524631_1 HI0933-like protein K07007 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003795 364.0
HKD2_k127_7524631_2 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit K00175 - 1.2.7.11,1.2.7.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001905 331.0
HKD2_k127_7530126_0 AcrB/AcrD/AcrF family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000005468 243.0
HKD2_k127_7530126_1 Domain of unknown function DUF302 - - - 0.000000000000000000000000000000005292 134.0
HKD2_k127_7530126_2 Protein of unknown function (DUF2892) - - - 0.000000000000000002085 89.0
HKD2_k127_7530126_3 pfam yhs - - - 0.00000000000321 74.0
HKD2_k127_7584309_0 Fe-S cluster domain protein - - - 0.0000000000000000000000000000000000000000000000000000000000000526 227.0
HKD2_k127_7584309_1 Domain in cystathionine beta-synthase and other proteins. K06041 - 5.3.1.13 0.0000000000000000000000000000000001305 143.0
HKD2_k127_7584309_2 DRTGG domain protein - - - 0.0000000000000000000000521 104.0
HKD2_k127_7584309_3 DRTGG domain - - - 0.000000000000001988 81.0
HKD2_k127_7613957_0 Pfam Adenylate and Guanylate cyclase catalytic domain K01768 - 4.6.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003178 424.0
HKD2_k127_7613957_1 COG2143 Thioredoxin-related protein - - - 0.0008 48.0
HKD2_k127_7617143_0 Pfam Transposase IS66 - - - 0.0000000000000000000000000000000000000000000000000000002434 202.0
HKD2_k127_7617143_1 - - - - 0.00000000000000000000000009123 120.0
HKD2_k127_7617143_2 PFAM RNP-1 like RNA-binding protein - - - 0.0000000000000000000000003143 112.0
HKD2_k127_7617143_3 FMN binding K03612 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000001074 109.0
HKD2_k127_761941_0 Protein of unknown function (DUF2490) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000007561 268.0
HKD2_k127_761941_1 Carbonic anhydrase K01673 - 4.2.1.1 0.0000000000000000000000000000000000000000000000000000000000000003879 231.0
HKD2_k127_761941_2 Predicted Permease Membrane Region - - - 0.0000000000000000000000000000000000000000000000000000009558 195.0
HKD2_k127_761941_3 - - - - 0.000000000000001557 85.0
HKD2_k127_761941_4 Bacterial SH3 domain - - - 0.00005674 51.0
HKD2_k127_7624408_0 Chemotaxis sensory transducer K03406 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001978 462.0
HKD2_k127_7624408_1 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000000000000000000000000000000000000000000000000002395 199.0
HKD2_k127_7624408_2 ABC transporter substrate binding protein K01989 - - 0.000000000001668 78.0
HKD2_k127_7661592_0 Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family K11102 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001917 568.0
HKD2_k127_7661592_1 Cytochrome c K17222 - - 0.00000000000000000005822 94.0
HKD2_k127_7661592_2 isochorismatase - - - 0.000000000000000003419 85.0
HKD2_k127_7661592_3 AMP binding - - - 0.0002042 49.0
HKD2_k127_766954_0 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit K02111 - 3.6.3.14 2.692e-231 725.0
HKD2_k127_766954_1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits K02112 - 3.6.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007609 529.0
HKD2_k127_766954_2 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex K02115 GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002624 305.0
HKD2_k127_766954_3 Synthesizes selenophosphate from selenide and ATP K01008 - 2.7.9.3 0.00000000000000000000001881 104.0
HKD2_k127_766954_4 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation K02113 - - 0.0000000000000003823 89.0
HKD2_k127_7676489_0 Transglycosylase K05365 - 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004729 454.0
HKD2_k127_7676489_1 - - - - 0.000000395 61.0
HKD2_k127_767774_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000004347 154.0
HKD2_k127_7689114_0 phospho-N-acetylmuramoyl-pentapeptide-transferase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000002095 246.0
HKD2_k127_7689114_1 SLBB domain K01991 - - 0.0000000000000000000003805 104.0
HKD2_k127_7689661_0 - - - - 0.000000000000000000000000001371 125.0
HKD2_k127_7718876_0 Spermine/spermidine synthase domain K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000000000000000000000000000147 244.0
HKD2_k127_7718876_1 Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another K02838 - - 0.000000000000000000000000000000001141 132.0
HKD2_k127_7725853_0 diguanylate cyclase - - - 0.00000000000000000000000000000000000000000000003007 179.0
HKD2_k127_7725853_1 ATP-independent chaperone mediated protein folding - - - 0.0001597 52.0
HKD2_k127_7735811_0 Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP K00575 - 2.1.1.80 0.000000000000000000000000000000000000000000000000000000000000000000000008136 258.0
HKD2_k127_7735811_1 catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR K03412 - 3.1.1.61,3.5.1.44 0.0000000000000000000000000000000000000000000000000000000000007966 229.0
HKD2_k127_7735811_2 HEAT repeat - - - 0.000000000000000000004635 108.0
HKD2_k127_7745809_0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates K00989,K02428 - 2.7.7.56,3.6.1.66 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001429 328.0
HKD2_k127_7745809_1 Aromatic amino acid lyase K01745 - 4.3.1.3 0.00000000000000000000000000000000000000000000000001418 183.0
HKD2_k127_7745809_2 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions K02428 - 3.6.1.66 0.00000000000000000000000000000000000000000000000007264 184.0
HKD2_k127_7745809_3 PFAM Lytic transglycosylase catalytic K08309 - - 0.0000000000000000000000000000004129 128.0
HKD2_k127_7745809_4 periplasmic protein-like - - - 0.0000000001567 71.0
HKD2_k127_7748154_0 PFAM Tetratricopeptide repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001376 390.0
HKD2_k127_776144_0 lipoprotein localization to outer membrane K02004,K09808 - - 0.000000000000000000000000000000000000000000000000000000000000001247 232.0
HKD2_k127_776144_1 methyltransferase - - - 0.000000007425 61.0
HKD2_k127_7769317_0 Glutamine synthetase type III N terminal K01915 - 6.3.1.2 1.119e-208 661.0
HKD2_k127_7769427_0 - - - - 0.00000000000000000000000000000000000000000001275 171.0
HKD2_k127_7769427_2 - - - - 0.00000009947 64.0
HKD2_k127_7777481_0 binding-protein-dependent transport systems inner membrane component K02025 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000668 303.0
HKD2_k127_7777481_1 Carbohydrate ABC transporter membrane protein 2, CUT1 family K02026 - - 0.0000000000000000000000000000000000000006248 156.0
HKD2_k127_7795572_0 response regulator K02481,K07715 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003016 319.0
HKD2_k127_7795572_2 cytochrome c oxidase subunit II K02275 - 1.9.3.1 0.0000000000005036 74.0
HKD2_k127_7795572_3 Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - 0.00001434 57.0
HKD2_k127_7795572_4 - - - - 0.00005061 52.0
HKD2_k127_7801702_0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 2.857e-201 675.0
HKD2_k127_7801702_1 Pyruvate phosphate dikinase, PEP/pyruvate binding domain K01007 - 2.7.9.2 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001009 548.0
HKD2_k127_7801702_2 glutamate dehydrogenase [NAD(P)+] activity K00260,K00261,K00262 GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.2,1.4.1.3,1.4.1.4 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003297 464.0
HKD2_k127_7844675_0 Diguanylate cyclase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005917 430.0
HKD2_k127_7861953_0 ABC-type antimicrobial peptide transport system, ATPase component K02003 - - 0.000000000000000000000000000000000000000000000000000002148 194.0
HKD2_k127_7861953_1 Thioesterase superfamily - - - 0.000000000000000000000000000001099 132.0
HKD2_k127_7861953_2 Bacterial membrane protein, YfhO - - - 0.000000000000000000000001321 114.0
HKD2_k127_7869205_0 PFAM Alcohol dehydrogenase, zinc-binding K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008546 329.0
HKD2_k127_7869205_1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - 0.000000000000000000000123 98.0
HKD2_k127_7869205_2 - - - - 0.0000000000000000005855 100.0
HKD2_k127_7875087_0 PFAM Integral membrane protein TerC K05794 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003679 428.0
HKD2_k127_7875087_1 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins K03798 - - 0.000000000000000000000000000000000000000007791 173.0
HKD2_k127_7884667_0 Putative esterase - - - 0.0000000000000004942 85.0
HKD2_k127_7884667_1 Bacterial regulatory proteins, tetR family - - - 0.0000000000005978 78.0
HKD2_k127_7884667_2 Serine aminopeptidase, S33 - - - 0.0000003021 61.0
HKD2_k127_7886786_0 - K07018 - - 0.00000000000000000000000000000000000000000000000003613 185.0
HKD2_k127_7886786_1 COG0346 Lactoylglutathione lyase and related lyases - - - 0.00000000000000000000000000001916 122.0
HKD2_k127_7905068_0 Belongs to the peptidase S8 family K14645 - - 0.000000000000000000000000000000000000000000000000000003432 211.0
HKD2_k127_7905068_1 sodium ABC transporter, permease K09696 - - 0.000000006405 67.0
HKD2_k127_7911382_0 copper-translocating P-type ATPase K17686 - 3.6.3.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002706 577.0
HKD2_k127_7922073_0 TIGRFAM molybdenum cofactor synthesis domain K03635 - 2.8.1.12 0.000000000000000005289 86.0
HKD2_k127_7922073_1 PFAM von Willebrand factor type A K07114,K12511 - - 0.00000000000002784 81.0
HKD2_k127_7922073_2 von Willebrand factor, type A K07114 - - 0.00003766 55.0
HKD2_k127_7929647_0 5'-nucleotidase, C-terminal domain K01081 - 3.1.3.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003535 449.0
HKD2_k127_7929647_1 The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) K00161,K11381,K21416 - 1.2.4.1,1.2.4.4 0.000000000007195 74.0
HKD2_k127_7935841_0 ATPase family associated with various cellular activities (AAA) K03924 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000196 407.0
HKD2_k127_7935841_1 Transglutaminase-like superfamily - - - 0.00000000000000000000000000000000000000000000000000000001225 207.0
HKD2_k127_7944342_0 PFAM Nucleotidyl transferase K00963 - 2.7.7.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002258 409.0
HKD2_k127_7944342_1 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity K02335 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002627 355.0
HKD2_k127_7944342_2 Regulatory protein, FmdB - - - 0.0000000000000000001575 92.0
HKD2_k127_7944342_3 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) K01875 - 6.1.1.11 0.0005154 48.0
HKD2_k127_7952206_0 Involved in the tonB-independent uptake of proteins - - - 0.0000000000000000000000000000000002435 140.0
HKD2_k127_7952206_1 PFAM Extracellular ligand-binding receptor - - - 0.000000000000000000000000000000001561 149.0
HKD2_k127_7952206_2 Diguanylate cyclase - - - 0.0001698 55.0
HKD2_k127_7959244_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - 9.767e-282 898.0
HKD2_k127_7959244_1 NADH ubiquinone oxidoreductase, NADH-binding K00124,K00335,K18331 - 1.12.1.3,1.6.5.3 8.563e-236 739.0
HKD2_k127_7959636_0 ATPase (AAA - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000003041 268.0
HKD2_k127_7959636_1 peptidyl-tyrosine sulfation - - - 0.0000000000000000000000000003229 125.0
HKD2_k127_7961608_0 Domain of unknown function (DUF1998) K06877 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003129 563.0
HKD2_k127_7961608_1 cAMP biosynthetic process K03641 - - 0.000006537 52.0
HKD2_k127_7963595_0 Glycosyl hydrolases family 2, TIM barrel domain K01190 - 3.2.1.23 0.00000000000000000000000000000000000000000000000000000000000001297 237.0
HKD2_k127_7963595_1 histidine kinase A domain protein K07677 - 2.7.13.3 0.000000000001414 81.0
HKD2_k127_7974417_0 ABC-type transport system involved in cytochrome c biogenesis permease component - - - 0.00000000000000000000000000000000000000000000000000000000000000002452 245.0
HKD2_k127_7974417_1 ResB-like family - - - 0.00000000000586 79.0
HKD2_k127_7979068_0 Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis K21071 - 2.7.1.11,2.7.1.90 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003809 520.0
HKD2_k127_7979068_1 4Fe-4S dicluster domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000008188 298.0
HKD2_k127_7979068_2 Rieske [2Fe-2S] domain - - - 0.0000000000000000000000000000000000000000000000000000000000008178 227.0
HKD2_k127_7979068_3 YwiC-like protein - - - 0.00000000000000000000000000000000000000000000000000000000006871 218.0
HKD2_k127_7979068_5 Belongs to the prokaryotic molybdopterin-containing oxidoreductase family K00372 - - 0.00000000000000000000000004622 109.0
HKD2_k127_7982618_0 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02469 - 5.99.1.3 1.229e-260 827.0
HKD2_k127_7982618_1 PFAM UvrD REP helicase K03657 - 3.6.4.12 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004137 586.0
HKD2_k127_7982618_2 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source K00820 GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004256 414.0
HKD2_k127_7982618_3 peptidyl-tyrosine sulfation - - - 0.00000000000000000000000000000000000000000000000000000000000001266 232.0
HKD2_k127_7982618_4 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner K02470 - 5.99.1.3 0.0000000000000000000000000000000001428 136.0
HKD2_k127_7998826_0 Inner membrane component of T3SS, cytoplasmic domain - GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - 0.0002417 53.0
HKD2_k127_8015906_0 A G-specific adenine glycosylase K03575 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000169 288.0
HKD2_k127_8015906_1 serine threonine protein kinase K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000001556 257.0
HKD2_k127_8015906_2 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine K00790 - 2.5.1.7 0.0000000000000000000000000000000000000000000000000000000000001226 217.0
HKD2_k127_8015906_3 Histidine triad (HIT) protein K02503 - - 0.000000000000000000000000000000000000000732 151.0
HKD2_k127_8015906_4 Protein conserved in bacteria - - - 0.00000000000000001239 97.0
HKD2_k127_8021714_0 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase K00322 - 1.6.1.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001574 346.0
HKD2_k127_8021714_1 Acyltransferase family - - - 0.00000000000000000000000000000001092 141.0
HKD2_k127_8021714_2 Protein of unknown function (DUF507) K09804 - - 0.0000000000001919 74.0
HKD2_k127_8021714_3 Protein of unknown function (DUF507) K09804 - - 0.0000000000002324 78.0
HKD2_k127_8031596_0 iron dependent repressor - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003438 555.0
HKD2_k127_8038602_0 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001222 292.0
HKD2_k127_8038602_1 Peptidase family M50 K11749 - - 0.00000000000000000000000000006244 125.0
HKD2_k127_8044861_0 GAF domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000002342 289.0
HKD2_k127_8044861_1 cell shape determining protein MreB K03569 - - 0.000000000000000000000000000000000000000006055 156.0
HKD2_k127_8053594_0 Protein of unknown function (DUF2400) K10773 - 4.2.99.18 0.00000000000000000000000000000000000000000000000000000000000000000000000003453 258.0
HKD2_k127_8070657_0 Domain of unknown function (DUF4178) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001337 336.0
HKD2_k127_8070657_1 Domain of Unknown Function (DUF350) - - - 0.00000000000324 71.0
HKD2_k127_8071202_0 Acetyl-coenzyme A synthetase N-terminus K01908 - 6.2.1.17 4.622e-317 979.0
HKD2_k127_8079683_0 Belongs to the MurCDEF family K02558 - 6.3.2.45 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002304 427.0
HKD2_k127_8079683_1 Glycoside hydrolase family 3 K01207 - 3.2.1.52 0.0000000000000000000000000000000001317 138.0
HKD2_k127_8079683_2 TonB dependent receptor K02014 - - 0.000000000000000000000000000008741 132.0
HKD2_k127_8080417_0 class II (D K K01893 - 6.1.1.22 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 603.0
HKD2_k127_8080417_1 Sulfatase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000778 261.0
HKD2_k127_8080417_2 phosphotransferase related to Ser Thr protein kinases K07102 - 2.7.1.221 0.000000000000000000000000000000000000000000000000000000000105 218.0
HKD2_k127_8080417_3 CAAX protease self-immunity - - - 0.000000000000000000000000000000000000000004072 158.0
HKD2_k127_8080417_4 Transglutaminase/protease-like homologues K01406 - 3.4.24.40 0.00000000002449 74.0
HKD2_k127_8081226_0 serine-type endopeptidase activity K04771 - 3.4.21.107 0.00000000000000000000000000000000000000000000000000001112 207.0
HKD2_k127_8082631_0 protein kinase activity K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008301 343.0
HKD2_k127_8101111_0 polysaccharide deacetylase - - - 0.00000000000000000006564 96.0
HKD2_k127_8101111_1 Polysaccharide biosynthesis protein - - - 0.000000304 63.0
HKD2_k127_8101111_2 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner K01338 - 3.4.21.53 0.00001036 57.0
HKD2_k127_8108725_0 ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner K06942 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002436 327.0
HKD2_k127_8108725_1 Glycosyl transferase family 2 - - - 0.000000000001493 78.0
HKD2_k127_8132639_0 PFAM NAD-dependent epimerase dehydratase K01784 - 5.1.3.2 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005331 448.0
HKD2_k127_8132639_1 CMP-N-acetylneuraminic acid synthetase - - - 0.00000000000000000000000000000000000000000000000000000000000002485 237.0
HKD2_k127_8132639_2 Polysaccharide biosynthesis protein - - - 0.00000000000000000000000000000000003316 153.0
HKD2_k127_8132639_3 Destroys radicals which are normally produced within the cells and which are toxic to biological systems K04565 - 1.15.1.1 0.000000000000001454 79.0
HKD2_k127_8132639_4 SAF domain K01654,K15898,K18430 - 2.5.1.101,2.5.1.56,2.5.1.97 0.0000000000008448 68.0
HKD2_k127_8138856_0 4 iron, 4 sulfur cluster binding - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002634 297.0
HKD2_k127_8138856_1 Calcineurin-like phosphoesterase K07099 - - 0.000000000000000000000000000000000000000003052 162.0
HKD2_k127_8151788_0 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA K01895 - 6.2.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002056 545.0
HKD2_k127_8151788_1 Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide K00639 - 2.3.1.29 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001459 471.0
HKD2_k127_8151788_2 COG2939 Carboxypeptidase C (cathepsin A) - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003132 336.0
HKD2_k127_8151788_4 acyl carrier protein - - - 0.00000003618 58.0
HKD2_k127_8160355_0 Belongs to the LarC family K09121 - 4.99.1.12 0.000000000000000000000000000000000000000000000000000000001132 209.0
HKD2_k127_8160355_1 Part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K02008 - - 0.00000000000000000000000000002191 132.0
HKD2_k127_8160355_2 ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates K16787 GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015238,GO:0015711,GO:0015893,GO:0016020,GO:0022857,GO:0032217,GO:0032218,GO:0034220,GO:0035461,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051180,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0090482,GO:0098656 - 0.00000000000524 78.0
HKD2_k127_8161227_0 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction K00925 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.7.2.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007379 463.0
HKD2_k127_8161227_1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain K00074 - 1.1.1.157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003406 319.0
HKD2_k127_8166917_0 Threonine/Serine exporter, ThrE - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003452 327.0
HKD2_k127_8166917_1 Methylmuconolactone methyl-isomerase - - - 0.000000000000001636 85.0
HKD2_k127_817784_0 Belongs to the 5'-nucleotidase family K11751 - 3.1.3.5,3.6.1.45 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002014 428.0
HKD2_k127_817784_1 Nucleotidyl transferase K00966 - 2.7.7.13 0.000000000000000000000000000000000000000000000002819 186.0
HKD2_k127_817784_2 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K01802,K03768 - 5.2.1.8 0.0000000000000000000000000000000007238 131.0
HKD2_k127_817784_3 PFAM Adenylate cyclase K05873 - 4.6.1.1 0.00000000000000000000000917 114.0
HKD2_k127_8186215_0 LytB protein K03527 - 1.17.7.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001524 339.0
HKD2_k127_8186215_1 Enoyl- acyl-carrier-protein reductase NADH K00208 GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0033554,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055114,GO:0065003,GO:0070417,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.10,1.3.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005643 292.0
HKD2_k127_8193336_0 PFAM Spermine spermidine synthase - - - 0.00000000000000000000000000000000009846 140.0
HKD2_k127_8193336_1 - - - - 0.00000000000000000042 96.0
HKD2_k127_8193336_2 Cytochrome C oxidase, cbb3-type, subunit III - - - 0.000000000001884 74.0
HKD2_k127_8226030_0 Belongs to the DNA polymerase type-C family. DnaE2 subfamily K14162 - 2.7.7.7 8.623e-291 912.0
HKD2_k127_8226030_1 His Kinase A (phosphoacceptor) domain - - - 0.0000000000000000000000000000775 125.0
HKD2_k127_8236497_0 - - - - 0.0000000000000000000000000000000000000000007078 163.0
HKD2_k127_8236497_1 Arm DNA-binding domain - - - 0.000000000000000000000000000000001828 139.0
HKD2_k127_8236497_2 Helix-turn-helix XRE-family like proteins K21498 - - 0.0000000000000168 76.0
HKD2_k127_8236497_3 - - - - 0.00005166 50.0
HKD2_k127_8236497_4 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase - - - 0.0002207 45.0
HKD2_k127_8237366_0 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit K02906 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000003197 252.0
HKD2_k127_8237366_1 One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome K02926 - - 0.00000000000000000000000000000000000000000000000000003104 197.0
HKD2_k127_8237366_2 Involved in the binding of tRNA to the ribosomes K02946 - - 0.0000000000000000000000000000000000000000000000000005936 186.0
HKD2_k127_8237534_0 PFAM Alcohol dehydrogenase zinc-binding domain protein K00344 - 1.6.5.5 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002693 409.0
HKD2_k127_8237534_1 Sortilin, neurotensin receptor 3, - - - 0.0000000000000000000000000000002529 128.0
HKD2_k127_8260099_0 ABC transporter C-terminal domain K06158 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001244 619.0
HKD2_k127_8260099_1 Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - 0.00000000002643 64.0
HKD2_k127_8263917_0 ABC transporter, transmembrane K18889 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006268 329.0
HKD2_k127_8263917_1 Deoxynucleoside kinase K15518 - 2.7.1.113 0.00000000000000000000000000000000000000000000000000000003399 202.0
HKD2_k127_8263917_2 nucleotide metabolic process - - - 0.0000000000000000000000000000000000000007328 165.0
HKD2_k127_8279133_0 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 5.87e-202 655.0
HKD2_k127_8279133_1 UvrD/REP helicase N-terminal domain K03657,K07465 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000003967 222.0
HKD2_k127_8279133_2 Surface antigen - - - 0.000000000000000000000000000000000000000000008218 171.0
HKD2_k127_8279133_3 Psort location Cytoplasmic, score 8.96 - - - 0.0000000000004198 72.0
HKD2_k127_8297678_0 Haem-degrading - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002155 344.0
HKD2_k127_8297678_1 Cytochrome c554 and c-prime - - - 0.0002081 53.0
HKD2_k127_8301443_0 Maf-like protein K06287 - - 0.000000000000000000000007396 104.0
HKD2_k127_8301704_0 COG1063 Threonine dehydrogenase and related Zn-dependent K00008 - 1.1.1.14 0.000000000000000000000000000000000000000000000000000000000000000000000000000000006302 274.0
HKD2_k127_8301704_1 CAAX protease self-immunity K07052 - - 0.0000000000000000000000000000000000000000000000000000005179 203.0
HKD2_k127_8312518_0 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity K00316 - 1.5.99.6 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009464 621.0
HKD2_k127_8312518_1 Belongs to the aldehyde dehydrogenase family K00128,K00130,K00146,K10217 - 1.2.1.3,1.2.1.32,1.2.1.39,1.2.1.8,1.2.1.85 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006113 508.0
HKD2_k127_8312640_0 Bacterial extracellular solute-binding proteins, family 5 Middle K02035 - - 0.000000000000000000000000000000000000000000000000000000000009431 226.0
HKD2_k127_8312640_1 PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen K03564 - 1.11.1.15 0.0002031 44.0
HKD2_k127_8324566_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007265 521.0
HKD2_k127_8324566_1 synthetase (ADP forming), alpha K01905,K09181,K22224 - 6.2.1.13 0.00000000000002565 77.0
HKD2_k127_8334494_0 PFAM Band 7 protein - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006144 324.0
HKD2_k127_8334494_1 NfeD-like C-terminal, partner-binding K07403 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000008887 259.0
HKD2_k127_835798_0 Outer membrane protein transport protein (OMPP1/FadL/TodX) K06076 - - 0.00000000000000000000000000000000000000000000001678 192.0
HKD2_k127_835798_1 lipase activity K15349 - - 0.0000000000000000000000000000004277 134.0
HKD2_k127_8378866_0 Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide K04656 - - 5.851e-207 656.0
HKD2_k127_8379217_0 PFAM Polysulphide reductase, NrfD - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002454 478.0
HKD2_k127_8379217_1 4Fe-4S dicluster domain - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001059 340.0
HKD2_k127_8379217_2 Glycine cleavage H-protein - - - 0.000000000000000000000000000000000005721 143.0
HKD2_k127_8385784_0 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily K00817,K04720 - 2.6.1.9,4.1.1.81 0.0000000000000000000000000000000000000000000000000000000000000000000002171 258.0
HKD2_k127_8385784_1 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine K00013 GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 0.000000000000000000000000000000000000000002223 162.0
HKD2_k127_8386601_0 Cation efflux family K16264 - - 0.000000000000000000000000000000000000000000000000000000000000000000000003404 250.0
HKD2_k127_8386601_1 Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin K06153 - 3.6.1.27 0.000000000000000000000000000000000000000000000000000000000000000000000038 252.0
HKD2_k127_8386601_2 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration K17758,K17759 - 4.2.1.136,5.1.99.6 0.0000000000000006145 90.0
HKD2_k127_8394838_0 Aminotransferase class I and II - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001341 505.0
HKD2_k127_8394838_1 Sulfatase - - - 0.000000000000000000000000000000000000009814 166.0
HKD2_k127_8405684_0 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle K01595 - 4.1.1.31 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001134 420.0
HKD2_k127_8405684_1 Lysozyme inhibitor LprI - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006717 417.0
HKD2_k127_8417924_0 Transcriptional regulatory protein, C terminal - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000001781 306.0
HKD2_k127_8417924_1 PhoQ Sensor - - - 0.000000000000000000000000000000000003095 140.0
HKD2_k127_8417924_2 Type II secretion system (T2SS), protein F K02455,K02653 - - 0.000000000000000000000000000000007278 136.0
HKD2_k127_8448812_0 Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily K17828 - 1.3.1.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000001041 287.0
HKD2_k127_8448812_1 Oxidoreductase NAD-binding domain K02823 - - 0.0000000000000000000000000000000000000000000000000005822 194.0
HKD2_k127_8448812_2 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.000005418 57.0
HKD2_k127_845515_0 Zn-dependent hydrolases including glyoxylases - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000289 376.0
HKD2_k127_845515_1 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000003368 296.0
HKD2_k127_845515_2 SMART helicase c2 K03722 - 3.6.4.12 0.0000000000000000000000000000000000000000000000000000000000000000000000000004239 268.0
HKD2_k127_8461118_0 DNA polymerase K02337 GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004199 557.0
HKD2_k127_8461118_1 endonuclease activity K07451 - - 0.000000000000000000000001919 109.0
HKD2_k127_8466683_0 Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties K00688 - 2.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002866 598.0
HKD2_k127_8466683_1 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides K03767 - 5.2.1.8 0.0000000000000000000000000000000000000000000000000000000000000000000001103 246.0
HKD2_k127_846954_0 Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP K03593 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002123 305.0
HKD2_k127_846954_1 Thioredoxin-like - - - 0.00000000000000000000000002042 119.0
HKD2_k127_846954_2 Putative regulatory protein - - - 0.0000000393 58.0
HKD2_k127_8470062_0 The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently K03076 GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002469 587.0
HKD2_k127_8470062_1 TIGRFAM methionine aminopeptidase, type I K01265 - 3.4.11.18 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002103 287.0
HKD2_k127_8470062_2 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism K00939 - 2.7.4.3 0.0000000000000000000000000000000000000000000000000000000000000111 224.0
HKD2_k127_8470062_3 Binds to the 23S rRNA K02876 - - 0.000000000000000000000000000000000000000000000000002124 186.0
HKD2_k127_8470062_4 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits K02952 - - 0.00000000000000000000000000000000000000000000000009641 179.0
HKD2_k127_8470062_5 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome K02948 - - 0.00000000000000000001824 93.0
HKD2_k127_8470062_6 Ribosomal protein L36 K02919 - - 0.0000000005847 61.0
HKD2_k127_8470062_7 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex K02518 GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - 0.0000001625 56.0
HKD2_k127_8475101_0 Citrate transporter - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004586 372.0
HKD2_k127_8475101_1 Dolichyl-phosphate-mannose-protein mannosyltransferase K00728 - 2.4.1.109 0.00000000000000000000000000000000000000000000000000001384 202.0
HKD2_k127_8475101_2 Thioredoxin domain - - - 0.0000000000000000000000000000001818 129.0
HKD2_k127_8475101_3 alkyl hydroperoxide reductase activity - - - 0.000000000000001198 78.0
HKD2_k127_8475101_4 Membrane - - - 0.000000003502 68.0
HKD2_k127_8479060_0 Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA K03438 GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000005626 298.0
HKD2_k127_8479060_1 Belongs to the MraZ family K03925 - - 0.00000000000000000000000000001003 121.0
HKD2_k127_8479060_2 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic - - - 0.0000002245 63.0
HKD2_k127_8479060_3 Penicillin-binding protein, dimerisation domain K03587 - 3.4.16.4 0.0007342 50.0
HKD2_k127_8487398_0 - - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002198 589.0
HKD2_k127_8490948_0 Membrane - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005489 454.0
HKD2_k127_8499109_0 Acyl-CoA dehydrogenase, N-terminal domain - - - 6.556e-202 643.0
HKD2_k127_8499828_0 transport, permease protein K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001219 312.0
HKD2_k127_8499828_1 ABC-2 family transporter protein - - - 0.000000000000000000000000000000000000000005355 164.0
HKD2_k127_8515497_0 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008223 494.0
HKD2_k127_8515497_1 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family K00826 - 2.6.1.42 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005413 436.0
HKD2_k127_8518783_0 2Fe-2S iron-sulfur cluster binding domain K00240 - 1.3.5.1,1.3.5.4 0.00000000000000000000000000000000000000000000000000000000000000000000000001898 259.0
HKD2_k127_8518783_1 Histidine kinase - - - 0.0000000000000000000001718 102.0
HKD2_k127_8518783_2 succinate dehydrogenase activity K00242,K00246 - - 0.000009166 53.0
HKD2_k127_8548300_0 Acyl-CoA dehydrogenase, middle domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002832 482.0
HKD2_k127_8548300_1 Protein of unknown function (DUF1572) - - - 0.0000000000000000000000000001336 121.0
HKD2_k127_8549822_0 Prolyl oligopeptidase family - - - 5.13e-276 866.0
HKD2_k127_8549822_1 PFAM sigma-54 factor interaction domain-containing protein K02584 - - 0.0000000000000000000000000000000000000000000000000000000000000000000001253 246.0
HKD2_k127_8549822_2 aminopeptidase N - - - 0.000000000000292 83.0
HKD2_k127_8553081_0 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) K03655 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000223 362.0
HKD2_k127_856295_0 aldehyde oxidase and xanthine dehydrogenase, a b hammerhead K20447 - 1.17.1.5 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005247 501.0
HKD2_k127_856295_1 Protein of unknown function (DUF1684) K09164 - - 0.000000000000000000000000000000000000000000000000000000372 197.0
HKD2_k127_856295_2 Protein of unknown function (DUF1684) K09164 - - 0.0000000000005358 75.0
HKD2_k127_8585685_0 Outer membrane efflux protein - - - 0.0000000000000000000000000000000005976 150.0
HKD2_k127_8585685_1 Bacterial regulatory proteins, tetR family - - - 0.00000000000000000001579 97.0
HKD2_k127_8585685_2 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - 0.000000001071 72.0
HKD2_k127_8585760_0 Involved in the tonB-independent uptake of proteins K08884,K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004006 321.0
HKD2_k127_8585760_1 Pirin K06911 - - 0.000000000000000000000000000000000000000000000000000000000007245 218.0
HKD2_k127_8591628_0 diguanylate cyclase - - - 0.000000000000000000000000000000000000000000000000000000000002563 230.0
HKD2_k127_8591628_1 - - - - 0.00000000000000000000000000000000004308 145.0
HKD2_k127_8591628_2 PFAM amine oxidase K21677 - 1.17.8.1 0.000000000039 66.0
HKD2_k127_8596980_0 acyl-CoA dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002738 448.0
HKD2_k127_8596980_1 Belongs to the helicase family. UvrD subfamily - - - 0.0000000000000000000000000000000000002656 151.0
HKD2_k127_8605508_0 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity K02343 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006253 384.0
HKD2_k127_8605623_0 Carbamoyltransferase C-terminus K00612 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007294 453.0
HKD2_k127_8605623_1 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - 0.00000000131 65.0
HKD2_k127_8605623_2 - - - - 0.00003901 51.0
HKD2_k127_8630087_0 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001142 376.0
HKD2_k127_8631926_0 Cellulose biosynthesis protein BcsQ K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001227 258.0
HKD2_k127_8631926_1 peroxiredoxin activity - - - 0.000000002294 58.0
HKD2_k127_863709_0 GAF domain - - - 0.0000000000000001647 94.0
HKD2_k127_863709_1 Histidine kinase K02480 - 2.7.13.3 0.00007719 56.0
HKD2_k127_8639369_0 Protein of unknown function (DUF1298) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002635 418.0
HKD2_k127_8639369_1 acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - 0.000000000003997 70.0
HKD2_k127_8640116_0 Molybdopterin oxidoreductase - - - 1.814e-230 728.0
HKD2_k127_8640116_1 surface antigen K07277,K07278 - - 0.000000000144 72.0
HKD2_k127_8661602_0 Type II/IV secretion system protein K02669 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002482 570.0
HKD2_k127_8661602_1 PFAM type II secretion system K02653 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002034 459.0
HKD2_k127_8661602_2 PFAM Type II secretion system protein E K02454,K02504,K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000007859 269.0
HKD2_k127_8661602_3 His Kinase A (phosphoacceptor) domain K02668 - 2.7.13.3 0.000000000000000000000000000000000000000000000000001821 201.0
HKD2_k127_8662138_0 Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate K00606 - 2.1.2.11 0.0000000000000000000000000000000000000000000000001646 181.0
HKD2_k127_8662138_1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid K00077 - 1.1.1.169 0.00000000000000000000000000000000000000000001415 179.0
HKD2_k127_8662499_0 Belongs to the class-I aminoacyl-tRNA synthetase family K01869 - 6.1.1.4 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003185 410.0
HKD2_k127_8662499_1 Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane K03643 GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264 - 0.00000000000000000007461 104.0
HKD2_k127_8670037_0 Amino acid permease - GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009376 337.0
HKD2_k127_8670037_1 Response regulator, receiver - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001718 329.0
HKD2_k127_8680765_0 Type II secretion system (T2SS), protein E, N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000008255 263.0
HKD2_k127_8680765_1 Trypsin K04771,K04772 - 3.4.21.107 0.000000002205 62.0
HKD2_k127_8683781_0 Belongs to the FPG family K10563 - 3.2.2.23,4.2.99.18 0.0000000000000000000000000000000000000000000000000000000000000000143 233.0
HKD2_k127_8683781_2 - - - - 0.000000000000000000000000346 110.0
HKD2_k127_8689033_0 Belongs to the DapA family K21062 - 3.5.4.22 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002334 421.0
HKD2_k127_8689033_1 FAD dependent oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000003361 263.0
HKD2_k127_869354_0 CarboxypepD_reg-like domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001711 533.0
HKD2_k127_8704327_0 AAA ATPase domain - - - 0.00000000000000000000000000000000000000000000003309 193.0
HKD2_k127_8715925_0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine K01696 - 4.2.1.20 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002826 481.0
HKD2_k127_8715925_1 The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate K01695 - 4.2.1.20 0.000000000000000000000000000000000000000001764 163.0
HKD2_k127_8715925_2 Belongs to the TrpF family K01817 - 5.3.1.24 0.000000000000000000000000000000001961 134.0
HKD2_k127_8725100_0 Pyridine nucleotide-disulphide oxidoreductase K00384,K21567 - 1.18.1.2,1.19.1.1,1.8.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003641 408.0
HKD2_k127_8725100_1 - - - - 0.0000000000000000000000000000000000000006382 164.0
HKD2_k127_8729556_0 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids K02313 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003082 492.0
HKD2_k127_8729556_1 Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria K02338 - 2.7.7.7 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002621 309.0
HKD2_k127_8729556_2 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP K03629 - - 0.00000000000000000001074 98.0
HKD2_k127_8733224_0 Asparaginase K01424 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.5.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005541 398.0
HKD2_k127_8736069_0 queuine tRNA-ribosyltransferase activity K00773 - 2.4.2.29 2.223e-274 863.0
HKD2_k127_8736069_1 Gamma-glutamyltranspeptidase K00681 - 2.3.2.2,3.4.19.13 8.045e-263 828.0
HKD2_k127_8736069_2 peptidase activity - - - 0.000000000000000000000000000000000000000000000000000000000000001379 238.0
HKD2_k127_8736069_3 Nodulation protein S (NodS) - - - 0.0000000000000000000000000000000000000000000000000000003687 198.0
HKD2_k127_8736069_4 Cobyrinic acid ac-diamide synthase K03496 - - 0.00000000000000000000000000000000000000000000000007156 180.0
HKD2_k127_8736069_5 FHA domain K07315 - 3.1.3.3 0.0000000001316 74.0
HKD2_k127_8736069_6 Metallo-beta-lactamase superfamily - - - 0.000000001963 66.0
HKD2_k127_8736984_0 Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine K04487 - 2.8.1.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002943 359.0
HKD2_k127_8736984_1 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives K03644 - 2.8.1.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003893 337.0
HKD2_k127_8742043_0 ABC transporter K06147,K18890 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001663 439.0
HKD2_k127_8742043_1 ABC transporter transmembrane region K18889 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000144 255.0
HKD2_k127_8751109_0 Calcineurin-like phosphoesterase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004348 335.0
HKD2_k127_8751109_1 MacB-like periplasmic core domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000939 231.0
HKD2_k127_8751109_2 - - - - 0.0000000000000008331 78.0
HKD2_k127_8765879_0 PFAM membrane bound O-acyl transferase, MBOAT family protein K19294 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003622 437.0
HKD2_k127_8765879_2 SGNH hydrolase-like domain, acetyltransferase AlgX - - - 0.000000000000000000000000007355 127.0
HKD2_k127_877202_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K15726 - - 0.0 1033.0
HKD2_k127_8780527_0 3-isopropylmalate dehydratase activity K01703 - 4.2.1.33,4.2.1.35 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007453 466.0
HKD2_k127_8780527_1 3-isopropylmalate dehydratase activity K01704 - 4.2.1.33,4.2.1.35 0.0000000000000000000000000000000000000000000000000000006678 210.0
HKD2_k127_8780925_0 CarD-like/TRCF domain K07736 - - 0.0000000000000000000000000000000000001009 150.0
HKD2_k127_8780925_1 Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions K05788 - - 0.0000000000000000000000008046 107.0
HKD2_k127_8780925_2 Aminotransferase class-V - - - 0.0000000000000000000005622 100.0
HKD2_k127_8780925_3 Domain of unknown function (DUF4388) - - - 0.00000000000000001297 91.0
HKD2_k127_8780925_4 Aminotransferase class-V - - - 0.000000000006159 71.0
HKD2_k127_8795326_0 Required for chromosome condensation and partitioning K03529 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000635 297.0
HKD2_k127_8796452_0 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site K03723 - - 6.448e-215 681.0
HKD2_k127_8796452_1 SurA N-terminal domain K03771 - 5.2.1.8 0.00000000000000000000000000005185 130.0
HKD2_k127_8796452_2 SurA N-terminal domain K03769 - 5.2.1.8 0.000000000000000000000007716 115.0
HKD2_k127_8796452_3 methylated DNA-protein cysteine methyltransferase K07443 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0005488,GO:0005515,GO:0019899,GO:0097159,GO:1901363 - 0.0000000000000000007326 90.0
HKD2_k127_8808412_0 COGs COG1022 Long-chain acyl-CoA synthetase (AMP-forming) K01897 - 6.2.1.3 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002434 512.0
HKD2_k127_8808412_1 Bacterial regulatory proteins, tetR family K13770 - - 0.000000000000000000000000000000000000000000000000003526 191.0
HKD2_k127_8810679_0 alanine dehydrogenase activity K00259 GO:0000286,GO:0001666,GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009628,GO:0009653,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030312,GO:0030435,GO:0032502,GO:0036293,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0050896,GO:0055114,GO:0070482,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.1.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000891 302.0
HKD2_k127_8810679_1 PFAM Thiamine pyrophosphate K00175,K00187 - 1.2.7.11,1.2.7.3,1.2.7.7 0.00000987 48.0
HKD2_k127_8815297_0 transport system involved in gliding motility, auxiliary K01992 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007495 325.0
HKD2_k127_8815297_1 ABC-2 family transporter protein K01992 - - 0.0000000000000000000000000000000000000000000000000000000008027 218.0
HKD2_k127_8815297_2 ABC transporter K01990 - - 0.0000000000000000000000000000000000000000000000000000003409 199.0
HKD2_k127_8824327_0 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate K00864 GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004786 474.0
HKD2_k127_8824327_1 Thioredoxin K03672 - 1.8.1.8 0.0000000000000000000000000000000000000000000000001797 197.0
HKD2_k127_8824327_2 Cyclic nucleotide-monophosphate binding domain K04739 - - 0.0000000000000000007517 99.0
HKD2_k127_8827254_0 Acyl-CoA dehydrogenase, N-terminal - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000002471 255.0
HKD2_k127_8827254_1 ABC-type nitrate sulfonate bicarbonate transport system ATPase component K02049,K15555 - - 0.0000000000000000000000000000000000000000000000000000000000000000007891 248.0
HKD2_k127_8827254_2 NMT1/THI5 like - - - 0.000000000000000000000000000000000000000000000000000000000000000009566 245.0
HKD2_k127_8827254_3 ABC-type nitrate sulfonate bicarbonate transport system permease component K02050 - - 0.00000000000000000000000000000000000000000000000000008765 196.0
HKD2_k127_8827737_0 3-hydroxyisobutyrate dehydrogenase K00020 - 1.1.1.31 0.0000000000000000000000000000000000000000000000000000000003008 220.0
HKD2_k127_8827737_1 RmuC family K09760 - - 0.00000000000000000000000000000000000000001981 167.0
HKD2_k127_8827737_2 Calcineurin-like phosphoesterase - - - 0.00000000000000000000000313 107.0
HKD2_k127_8827737_3 Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) K01770,K12506 - 2.7.7.60,4.6.1.12 0.000000000000000009307 87.0
HKD2_k127_8838705_0 Histone deacetylase domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000001296 262.0
HKD2_k127_8838705_1 methyltransferase - - - 0.00000000000000000000000000000000000000000000000000000000000000000000002435 251.0
HKD2_k127_88389_0 DJ-1/PfpI family K05520 - 3.5.1.124 0.000000000000004593 76.0
HKD2_k127_88389_1 to Shigella flexneri,and Shigella flexneri 2A IS10 orf S0034 or Cp0027 SWALL Q9AFX7 (EMBL AF348706) (407 aa) fasta scores E() - - - 0.000000281 63.0
HKD2_k127_886161_0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - 0.000000000000000000000000000000000000000000000000000000000000000003879 250.0
HKD2_k127_8890378_0 Pyridoxal-phosphate dependent enzyme K01738 - 2.5.1.47 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005472 456.0
HKD2_k127_8890378_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001452 407.0
HKD2_k127_8907882_0 GTP-binding protein TypA K06207 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003098 355.0
HKD2_k127_8907882_1 Sigma-54 interaction domain K11384 - - 0.000000000000000000000000000000001553 135.0
HKD2_k127_8907882_2 Iron-sulfur cluster-binding domain - - - 0.00000000000000000125 100.0
HKD2_k127_8912326_0 Acyl transferase domain - - - 1.116e-281 880.0
HKD2_k127_8912326_1 TIGRFAM PfaD family protein - - - 0.00000000000000000003418 90.0
HKD2_k127_8929812_0 Cyclic nucleotide-monophosphate binding domain - - - 0.00000000000000000000000000000000000002515 149.0
HKD2_k127_8929812_1 cheY-homologous receiver domain K07315 - 3.1.3.3 0.000000000000000000000000000004136 123.0
HKD2_k127_8929812_2 - - - - 0.0000000000000000000005029 109.0
HKD2_k127_8932047_0 glucose-6-phosphate isomerase activity K01810 - 5.3.1.9 4.391e-243 777.0
HKD2_k127_8932047_1 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family K00823 - 2.6.1.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001156 380.0
HKD2_k127_8932047_2 Belongs to the peptidase S26 family - - - 0.0000000000000000000000000000002281 130.0
HKD2_k127_8950993_0 Trypsin - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003905 568.0
HKD2_k127_8965182_0 PFAM Glycosyl transferases group 1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000001218 300.0
HKD2_k127_8971352_0 His Kinase A (phosphoacceptor) domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000001963 252.0
HKD2_k127_8971352_1 PFAM aldo keto reductase K05882 - 1.1.1.91 0.000000000000000000000000000000001865 133.0
HKD2_k127_8976232_0 Adenylyl- / guanylyl cyclase, catalytic domain - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005596 344.0
HKD2_k127_8976232_1 HD domain - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001521 344.0
HKD2_k127_8976232_2 NAD-dependent glycerol-3-phosphate dehydrogenase domain protein K00057 - 1.1.1.94 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001702 314.0
HKD2_k127_8976232_3 Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP K08591 - 2.3.1.15 0.0000000000000000000000000000000000008177 151.0
HKD2_k127_8976232_4 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components K03110 - - 0.000000000000000001469 94.0
HKD2_k127_8976232_5 Tetratricopeptide repeat - - - 0.0000000000000004595 93.0
HKD2_k127_8976232_6 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester K01975 - 3.1.4.58 0.00000000000002379 76.0
HKD2_k127_8976232_7 Roadblock/LC7 domain - - - 0.000000006063 62.0
HKD2_k127_8984116_0 Aminotransferase class-III - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007984 325.0
HKD2_k127_8984116_1 Aldehyde dehydrogenase family K00140 - 1.2.1.18,1.2.1.27 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002345 310.0
HKD2_k127_8998038_0 Putative heavy-metal-binding - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009243 373.0
HKD2_k127_8998038_1 - - - - 0.00001182 53.0
HKD2_k127_9005049_0 TIGRFAM Hydrogenase accessory protein HypB K04652 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000003651 300.0
HKD2_k127_9005049_1 hydrogenase expression formation protein HypE K04655 - - 0.0000000000000000000000000000000000000000000000000000000000002638 217.0
HKD2_k127_9005049_2 Probably plays a role in a hydrogenase nickel cofactor insertion step K04651 - - 0.000000000000000000000000000000388 125.0
HKD2_k127_901204_0 ATP-dependent Clp protease ATP-binding subunit ClpA K03694 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002764 546.0
HKD2_k127_901204_1 ATP-dependent Clp protease adaptor protein ClpS K06891 - - 0.000000000000000000000000000000001146 132.0
HKD2_k127_901204_2 Fatty acid hydroxylase superfamily - - - 0.00000000000001057 82.0
HKD2_k127_9034044_0 Glycosyl transferases group 1 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003457 388.0
HKD2_k127_9034044_1 penicillin-binding protein K05367 - 2.4.1.129 0.000000000000000000321 93.0
HKD2_k127_9045742_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004162 427.0
HKD2_k127_9045742_1 Ribosomal_S15 K02956 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - 0.0000000000000000000000000000000000002792 142.0
HKD2_k127_905865_0 MazG nucleotide pyrophosphohydrolase domain K02428,K02499 GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66 0.000000000000000000000000000000000000000000000000000000000000000000000001471 258.0
HKD2_k127_905865_1 3'-5' exonuclease K03684 - 3.1.13.5 0.0000000000000000000000000000000000000000000000000000000000002772 233.0
HKD2_k127_905865_2 ABC nitrate sulphonate bicarbonate family transporter, ATPase subunit K02049 - - 0.000000000000000000000000000007955 121.0
HKD2_k127_9066303_0 PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003822 397.0
HKD2_k127_9066303_1 Homocysteine S-methyltransferase K00547 - 2.1.1.10 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000007582 300.0
HKD2_k127_9100349_0 5'-nucleotidase, C-terminal domain K11751 - 3.1.3.5,3.6.1.45 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002447 490.0
HKD2_k127_9116151_0 Putative stress-induced transcription regulator - - - 0.000000000000000000000001707 106.0
HKD2_k127_9116151_1 manganese ion transmembrane transporter activity - - - 0.00000000000000000005944 104.0
HKD2_k127_9116151_2 Alpha beta hydrolase - - - 0.0000000000000000002397 97.0
HKD2_k127_9136348_0 PFAM glycosyl transferase family 2 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001225 358.0
HKD2_k127_9136348_1 Glycosyltransferase Family 4 - - - 0.00000000000000000000000000000000000007165 163.0
HKD2_k127_9136348_2 His Kinase A (phosphoacceptor) domain - - - 0.0000000001647 73.0
HKD2_k127_9136348_3 NmrA-like family - - - 0.0006429 45.0
HKD2_k127_9138136_0 Part of an ABC transporter complex. Responsible for energy coupling to the transport system K02006,K02008 - - 0.00000000000000000000000000000000000000000000000000000000000000000000008081 263.0
HKD2_k127_9138136_1 Cobalt transport protein K02008 - - 0.0000000000000000000004378 103.0
HKD2_k127_9138136_2 PDGLE domain K02007 - - 0.00000000000000000002094 97.0
HKD2_k127_9138136_3 - - - - 0.00003924 55.0
HKD2_k127_9140669_0 Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis K02535,K13599 - 3.5.1.108 0.00000000000000000000000000000000000000000000000000000002701 202.0
HKD2_k127_9140669_1 RNA polymerase sigma factor K03088 - - 0.00000000000000000000000000000000000000007813 162.0
HKD2_k127_9140669_2 S1 P1 Nuclease - - - 0.000000000000000000001593 106.0
HKD2_k127_9140669_3 COG NOG19146 non supervised orthologous group - - - 0.00000000009958 71.0
HKD2_k127_9140669_4 Competence protein - GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575 - 0.00002569 47.0
HKD2_k127_9140669_5 STAS domain K04749 - - 0.0003061 52.0
HKD2_k127_9156471_0 arylsulfatase activity - - - 0.000000000000000000000000000000000000000000000001516 192.0
HKD2_k127_9160223_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain K00335 - 1.6.5.3 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000447 547.0
HKD2_k127_9160223_1 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 K00330 - 1.6.5.3 0.0000000000000000000000000000000005255 136.0
HKD2_k127_9160223_2 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone K00337 - 1.6.5.3 0.00000000000000000000000002577 111.0
HKD2_k127_9160242_0 Methylenetetrahydrofolate reductase K00297,K00547,K00548 - 1.5.1.20,2.1.1.10,2.1.1.13 0.00000000000000000000000000000000001745 143.0
HKD2_k127_9176393_0 Belongs to the glycosyl hydrolase 57 family K16149 - 2.4.1.18 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001973 586.0
HKD2_k127_9176393_1 Memo-like protein K06990 - - 0.00000000000000000000000000000000000000000000000000000004577 207.0
HKD2_k127_9176393_2 AMMECR1 K09141 - - 0.000000000000000000000000000000000000007472 160.0
HKD2_k127_9183293_0 Glycosyl transferase family 1 - - - 0.00000000000000000000000000000000000000000000000000000000001114 220.0
HKD2_k127_9183293_1 PhoQ Sensor - - - 0.00000000000000000002869 106.0
HKD2_k127_9183293_2 Uncharacterized protein family UPF0004 K14441 - 2.8.4.4 0.0000000000000002659 85.0
HKD2_k127_9205380_0 aminopeptidase activity K01266 - 3.4.11.19 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001758 421.0
HKD2_k127_9205380_1 DinB superfamily - - - 0.0000000000000000000000000000000000000000000002911 174.0
HKD2_k127_9205380_2 Pfam Adenylate and Guanylate cyclase catalytic domain - - - 0.00000000000485 68.0
HKD2_k127_9215012_0 subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali K05568 GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000796 312.0
HKD2_k127_9215012_1 NADH dehydrogenase - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000006743 289.0
HKD2_k127_9215012_2 Hydrogenase 4 membrane K12140 - - 0.0000000000000000000000000000000000000000004949 166.0
HKD2_k127_9215012_3 PFAM NADH Ubiquinone plastoquinone (complex I) - - - 0.0000000000000000000002443 102.0
HKD2_k127_9220706_0 Belongs to the SIS family. GutQ KpsF subfamily K06041 - 5.3.1.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006192 372.0
HKD2_k127_9220706_1 TIGRFAM 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 - 3.1.3.45 0.0000000000000000000000000000000000000002922 167.0
HKD2_k127_9220706_2 Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane K19804 - - 0.000004126 54.0
HKD2_k127_9224481_0 Major facilitator superfamily MFS_1 - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008286 380.0
HKD2_k127_9224481_1 Major facilitator superfamily K05939 - 2.3.1.40,6.2.1.20 0.00000000000000000005602 94.0
HKD2_k127_9247837_0 PFAM Patatin - - - 0.000000000000000000000000000000000000001449 165.0
HKD2_k127_9248648_0 PFAM alanine racemase domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005093 320.0
HKD2_k127_9248648_1 Belongs to the radical SAM superfamily. RlmN family K06941 - 2.1.1.192 0.00000000000000000000000000000284 124.0
HKD2_k127_9258408_0 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000007224 498.0
HKD2_k127_9258408_1 ATP-independent chaperone mediated protein folding - - - 0.0000000000000000000001007 101.0
HKD2_k127_9258408_2 - - - - 0.0000000000000000000001472 107.0
HKD2_k127_9267124_0 Sortilin, neurotensin receptor 3, - - - 0.0 1058.0
HKD2_k127_9270279_0 PFAM peptidase U62 modulator of DNA gyrase K03592 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 446.0
HKD2_k127_9270279_1 WD40-like Beta Propeller Repeat - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002074 344.0
HKD2_k127_9270279_2 Metallopeptidase family M24 K14213 GO:0003674,GO:0003824,GO:0004180,GO:0004181,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016787,GO:0019538,GO:0019752,GO:0031974,GO:0031981,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0070011,GO:0070013,GO:0071704,GO:0140096,GO:1901564 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000002105 304.0
HKD2_k127_9278865_0 NUBPL iron-transfer P-loop NTPase K03496 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001748 312.0
HKD2_k127_9278865_1 Belongs to the ParB family K03497 - - 0.00000000000000000000000000000000000000000000003604 173.0
HKD2_k127_9278865_2 Specifically methylates the N7 position of a guanine in 16S rRNA K03501 - 2.1.1.170 0.000000000000000002321 97.0
HKD2_k127_9278865_3 R3H domain protein K06346 - - 0.000000001555 66.0
HKD2_k127_9285749_0 PFAM AMP-dependent synthetase and ligase K01897 - 6.2.1.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008899 593.0
HKD2_k127_9285749_1 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII K02346 - 2.7.7.7 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003316 387.0
HKD2_k127_9285749_2 ethanolamine utilization protein EutN carboxysome structural protein Ccml K04028 GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - 0.0000000000000000002222 90.0
HKD2_k127_9285749_3 Ethanolamine utilisation protein EutN/carboxysome K04028 - - 0.0001499 45.0
HKD2_k127_9315184_0 Alpha-2-Macroglobulin K06894 - - 0.00000000000000000000000000000000000000000000000000000000000000001864 239.0
HKD2_k127_9315184_1 Penicillin-Binding Protein C-terminus Family K05367 - 2.4.1.129 0.000000000000000000000000000000905 128.0
HKD2_k127_9330834_0 His Kinase A (phosphoacceptor - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001578 344.0
HKD2_k127_9335175_0 Aldehyde dehydrogenase family K00294 - 1.2.1.88 2.802e-238 744.0
HKD2_k127_933633_0 ABC-type dipeptide transport system periplasmic component K02035 - - 0.0000000000000000000000000000000000000000000000000000001609 211.0
HKD2_k127_933633_1 DEAD DEAH box helicase - - - 0.000000000000000000000000000001235 123.0
HKD2_k127_935629_0 ABC transporter, ATP-binding protein K01990 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000805 276.0
HKD2_k127_935629_1 - - - - 0.00000000000000000000000000000000000001764 159.0
HKD2_k127_935629_2 Pfam:N_methyl_2 - - - 0.000000000000001401 84.0
HKD2_k127_9356607_0 Radical SAM K18537,K21224 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004375 319.0
HKD2_k127_9367657_0 membrane organization K07277,K09800 - - 0.0000000000000000000000006695 107.0
HKD2_k127_9373730_0 Heat shock 70 kDa protein K04043 - - 1.84e-209 659.0
HKD2_k127_9373730_1 DnaJ C terminal domain - - - 0.0000000000000001803 81.0
HKD2_k127_9384754_0 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002805 398.0
HKD2_k127_9384754_1 ABC-type antimicrobial peptide transport system, permease component K02004 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006034 375.0
HKD2_k127_9384754_2 Barrel-sandwich domain of CusB or HlyD membrane-fusion K02005 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002507 295.0
HKD2_k127_9384754_3 ABC transporter K02003 - - 0.000000000000000000000000000000000000006686 165.0
HKD2_k127_9385137_0 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004584 534.0
HKD2_k127_9385137_1 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions K04077 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000006406 288.0
HKD2_k127_9385137_2 LysR substrate binding domain K03717 - - 0.00000000000000000000000000000000000000001514 156.0
HKD2_k127_9385137_3 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter K04078 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - 0.00000000000000000000000000000000002003 143.0
HKD2_k127_939778_0 PFAM peptidase M13 K01415 - 3.4.24.71 6.506e-201 661.0
HKD2_k127_939778_1 Asparaginase K01424 - 3.5.1.1 0.00000000000000000000000000001951 117.0
HKD2_k127_939778_2 - - - - 0.000000000000000000001441 102.0
HKD2_k127_9405159_0 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth K03086 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002442 336.0
HKD2_k127_9412937_0 3-oxoacid CoA-transferase, a subunit K01027,K01028,K01031,K01034 - 2.8.3.5,2.8.3.6,2.8.3.8,2.8.3.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004007 557.0
HKD2_k127_9412937_1 spermidine synthase activity - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001672 410.0
HKD2_k127_9412937_2 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) K12944 GO:0003674,GO:0003824,GO:0004170,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0047429,GO:0047840 - 0.000000000000007626 78.0
HKD2_k127_9412937_3 histone H2A K63-linked ubiquitination - - - 0.0001777 46.0
HKD2_k127_9416922_0 tungstate binding K02020 GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0030288,GO:0030313,GO:0030973,GO:0031975,GO:0040007,GO:0042597,GO:0043167,GO:0043168,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0051704 - 0.000000000000000000000000000000000000000000000000003475 193.0
HKD2_k127_9416922_1 Sigma-54 interaction domain - - - 0.00000000000000000007806 98.0
HKD2_k127_9416922_2 Belongs to the DegT DnrJ EryC1 family - - - 0.00000000000003007 74.0
HKD2_k127_9416922_3 UDP-4-amino-4-deoxy-L-arabinose aminotransferase - - - 0.0003215 45.0
HKD2_k127_9427673_0 ATPase activity K01990,K13926 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000001976 293.0
HKD2_k127_9427673_1 HlyD family secretion protein K01993 - - 0.00000000000000000000000000000000000000000000000000000001122 217.0
HKD2_k127_9427673_2 Bacterial regulatory proteins, tetR family - - - 0.0000000000000000000000000418 115.0
HKD2_k127_9428057_0 PFAM WD40 domain protein beta Propeller - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005076 383.0
HKD2_k127_9428057_1 response regulator, receiver - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004663 266.0
HKD2_k127_9428057_2 Histidine kinase - - - 0.000000000000000000000000000000008802 133.0
HKD2_k127_9438178_0 Aminopeptidase P, N-terminal domain K01262 - 3.4.11.9 0.0000000000000000000000000000000000000000002261 171.0
HKD2_k127_9438178_1 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.0000000000000000000000001061 120.0
HKD2_k127_9441122_0 Acetyltransferase (GNAT) domain - - - 0.000000000000000000000000000000000000000000000000000209 198.0
HKD2_k127_9441122_1 Fatty acid hydroxylase superfamily - - - 0.00000000000000364 82.0
HKD2_k127_9448125_0 TrkA-C domain K03499 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000008501 281.0
HKD2_k127_9448125_1 TrkA-N domain K03499,K10716 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000002148 267.0
HKD2_k127_9448125_2 Amino acid permease - GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - 0.00000000000000000000000000000000000000002439 154.0
HKD2_k127_9448125_3 PFAM Response regulator receiver domain K07662 - - 0.0000000000000000000002405 100.0
HKD2_k127_9450263_0 - - - - 0.000000000000000000000000000000000000000000005008 175.0
HKD2_k127_9450263_1 Ferredoxin - - - 0.0000000000000000000000009662 106.0
HKD2_k127_9454239_0 Aldehyde dehydrogenase K00131 - 1.2.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001352 492.0
HKD2_k127_9454239_1 PAP2 superfamily C-terminal - - - 0.0000000000000000000000000000000000000000000000001487 189.0
HKD2_k127_9454239_2 Phosphate acyltransferases - - - 0.0002279 49.0
HKD2_k127_945616_0 Acyl-CoA dehydrogenase, C-terminal domain K00248 - 1.3.8.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001815 600.0
HKD2_k127_9457603_0 PFAM glycoside hydrolase, family 77 K00705 - 2.4.1.25 9.632e-194 620.0
HKD2_k127_9457603_1 MFS/sugar transport protein K16211 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003274 535.0
HKD2_k127_9457603_2 tRNA processing K06864,K09121 - 4.99.1.12 0.0000000000000000000000000000000000000000000000000000000000000001192 234.0
HKD2_k127_9457603_3 AIR carboxylase K06898 - - 0.0008219 51.0
HKD2_k127_9465203_0 Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring K03590 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001505 549.0
HKD2_k127_9465203_1 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity K03531 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000003523 286.0
HKD2_k127_9466348_0 MMPL family K03296 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009303 535.0
HKD2_k127_9466348_1 Biotin-lipoyl like K07799 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000008049 311.0
HKD2_k127_9466348_2 Transglycosylase K05366 GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 0.000000000000000000000000000000000000000009832 158.0
HKD2_k127_9466348_3 helix_turn_helix multiple antibiotic resistance protein - - - 0.00002305 53.0
HKD2_k127_9468604_0 Glycosyl transferase family 21 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001228 264.0
HKD2_k127_9468604_1 Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity K07456 - - 0.00000000000000000000000000000000000000000000000000000000000000000000006039 254.0
HKD2_k127_9477778_0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster K03388,K12527 - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9 0.000000000000000000000000000000000000000000000000000000000000000000000000000001738 269.0
HKD2_k127_9477778_1 Polysaccharide lyase family 4, domain II - - - 0.000000000000000000000000000000000000000000000000908 180.0
HKD2_k127_9488298_0 NHLM bacteriocin system ABC transporter, peptidase ATP-binding protein - - - 3.801e-256 805.0
HKD2_k127_9488298_1 NHLM bacteriocin system ABC transporter, ATP-binding protein K06148 - - 2.405e-221 719.0
HKD2_k127_9491958_0 Belongs to the PEP-utilizing enzyme family K01006,K22424 - 2.7.3.13,2.7.9.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002143 600.0
HKD2_k127_9491958_1 Mediates influx of magnesium ions K03284 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000001388 270.0
HKD2_k127_9491958_2 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex K03572 GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - 0.00000000000000000000000000000000000000001512 156.0
HKD2_k127_950758_0 NeuB family K03856 - 2.5.1.54 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001238 430.0
HKD2_k127_950758_1 ATPases associated with a variety of cellular activities K01990 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002835 279.0
HKD2_k127_950758_2 Prephenate dehydrogenase K04517 - 1.3.1.12 0.0000000000000000000000000000000004225 152.0
HKD2_k127_950758_3 - K01992 - - 0.00002164 58.0
HKD2_k127_9512274_0 Amidohydrolase family - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001811 627.0
HKD2_k127_9516638_0 PFAM Type II secretion system protein E K02652 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002773 402.0
HKD2_k127_9518544_0 membrane protein involved in D-alanine - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000001404 254.0
HKD2_k127_9518544_1 Protein kinase domain K12132 - 2.7.11.1 0.00000000000000000000000000000000000000000000000000000000000000000006593 239.0
HKD2_k127_9522054_0 Molybdopterin oxidoreductase K07812,K08352 - 1.7.2.3,1.8.5.5 1.95e-219 703.0
HKD2_k127_9522054_1 COG0437 Fe-S-cluster-containing hydrogenase components 1 K00184 - - 0.0000000000000000000000000000000000000000000000000414 188.0
HKD2_k127_9522351_0 Radical SAM domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000003203 267.0
HKD2_k127_9522351_2 Peptidase family C25 - - - 0.0000000001112 64.0
HKD2_k127_9523404_0 NAD binding K00333,K13378 - 1.6.5.3 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003287 477.0
HKD2_k127_9523404_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00332 - 1.6.5.3 0.0000000000000000000000000000000000000000003512 164.0
HKD2_k127_952964_0 AIR synthase related protein, C-terminal domain - - - 0.00000000000000000000000000000000005552 138.0
HKD2_k127_952964_1 Dual specificity phosphatase, catalytic domain - - - 0.0000000000000001921 91.0
HKD2_k127_9530747_0 Bacterial membrane protein, YfhO - - - 0.000000000000000000005461 108.0
HKD2_k127_9535600_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 7.873e-199 629.0
HKD2_k127_9535600_1 Cytochrome c biogenesis protein K06196 - - 0.0000000000000000000000000000000000000000000000000000000000000001419 234.0
HKD2_k127_9535600_2 Pas domain - - - 0.0000000000000001226 94.0
HKD2_k127_9536197_0 GGDEF domain containing protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008954 395.0
HKD2_k127_9536197_1 PFAM aldo keto reductase - - - 0.000000000000000000000000000000000000000000008084 166.0
HKD2_k127_9537293_0 Dna alkylation repair - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000004294 266.0
HKD2_k127_9537293_1 dCMP deaminase activity K01493 - 3.5.4.12 0.000000000000000000000000000000000000000001303 160.0
HKD2_k127_9537293_2 GYD domain - - - 0.000000000000000000000000005779 122.0
HKD2_k127_9537293_3 Belongs to the phosphoglycerate mutase family K01834,K22306 GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0042578,GO:0044237 3.1.3.85,5.4.2.11 0.0000000000002114 83.0
HKD2_k127_9551585_0 Insulinase (Peptidase family M16) K07263 - - 3.359e-198 627.0
HKD2_k127_9551585_1 Peptidase, M16 - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003892 376.0
HKD2_k127_9551748_0 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III K01599 GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002546 442.0
HKD2_k127_9551748_1 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX K00231 - 1.3.3.15,1.3.3.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008725 351.0
HKD2_k127_9551748_2 Catalyzes the ferrous insertion into protoporphyrin IX K01772 GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 0.00000000000000000000000000000000000000000000000000000000000000000000007518 265.0
HKD2_k127_9551748_3 TonB-dependent Receptor Plug Domain K02014,K16092 - - 0.00000000000000000002184 100.0
HKD2_k127_9564991_0 Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN K03186 GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.129 0.000000000000000000000000000000000000000000000000000000000000000000009606 241.0
HKD2_k127_9564991_1 Domain of unknown function (DUF4178) - - - 0.0000000000000000000000000000000000000000000000000000000000109 224.0
HKD2_k127_9564991_2 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine K01611 - 4.1.1.50 0.000000000000000000000000000000003978 141.0
HKD2_k127_9568845_0 protein conserved in bacteria K09927 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001311 484.0
HKD2_k127_9568845_1 PFAM Short-chain dehydrogenase reductase SDR - - - 0.000000000000000000000000000000000786 132.0
HKD2_k127_9577953_0 PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase K11206 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000004272 295.0
HKD2_k127_9577953_1 Belongs to the universal ribosomal protein uS2 family K02967 GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.000000000000000000000000000000000000000000000000000000000000000000000000008283 263.0
HKD2_k127_9577953_2 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly K02871 GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - 0.0000000000000000000000000000000000000000000000002803 182.0
HKD2_k127_9577953_3 structural constituent of ribosome K02996 - - 0.000000000000000000000000000000000000000004287 158.0
HKD2_k127_9597634_0 - - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003347 347.0
HKD2_k127_960007_0 - - - - 0.000000000004315 72.0
HKD2_k127_960007_1 Condensation domain - - - 0.0000002529 61.0
HKD2_k127_960007_2 Phosphopantetheine attachment site K02078 - - 0.0004348 51.0
HKD2_k127_9601399_0 acyl-CoA dehydrogenase activity K00249 - 1.3.8.7 7.596e-249 779.0
HKD2_k127_9601399_1 oligopeptide transport K03305 - - 0.000000000000000000000000000000000000000000000000000000000000001075 241.0
HKD2_k127_9601399_2 Putative zinc- or iron-chelating domain K06940 - - 0.00000002573 58.0
HKD2_k127_9603473_0 PspA/IM30 family K03969 - - 0.0000000000000000000000000000000000000000000000000000000000000000002832 241.0
HKD2_k127_9603473_1 ribose 5-phosphate isomerase B K01808 - 5.3.1.6 0.00000000000000000000000000000000000000000000001351 179.0
HKD2_k127_9603473_2 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism K00600 - 2.1.2.1 0.0000000000000000000000000003887 116.0
HKD2_k127_9605016_0 saccharopine dehydrogenase activity - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002188 323.0
HKD2_k127_9605016_1 AAA domain - - - 0.000000000000000000000000000004894 130.0
HKD2_k127_9605016_2 Responsible for synthesis of pseudouridine from uracil K06180 - 5.4.99.23 0.0007783 46.0
HKD2_k127_9623641_0 arylsulfatase activity - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000005434 293.0
HKD2_k127_9623641_1 COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes K00164 - 1.2.4.2 0.00000000000000000000000000002475 120.0
HKD2_k127_9628557_0 NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004667 582.0
HKD2_k127_9628557_1 Belongs to the complex I subunit 6 family K00339 - 1.6.5.3 0.0000000000000000000000000008296 120.0
HKD2_k127_9628557_2 Multisubunit Na H antiporter MnhC subunit K00340,K05567 - 1.6.5.3 0.0000000000000000002845 97.0
HKD2_k127_9632734_0 dihydrolipoamide dehydrogenase K00382 - 1.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001523 386.0
HKD2_k127_9632734_1 Transporter associated domain K03699,K06189 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002312 312.0
HKD2_k127_9646138_0 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control K03979 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004435 351.0
HKD2_k127_9646138_1 WD40-like Beta Propeller Repeat K03641,K07277 - - 0.00000000000000000000000000000000000000000000002774 182.0
HKD2_k127_9646138_2 Belongs to the bacterial ribosomal protein bL27 family K02899 - - 0.0000000000000000000000000000008448 123.0
HKD2_k127_9646138_3 This protein binds to 23S rRNA in the presence of protein L20 K02888 - - 0.000000000000000000000000000001641 124.0
HKD2_k127_9649373_0 HAD-hyrolase-like K01091 - 3.1.3.18 0.000000000000000000000000000000000000000007789 163.0
HKD2_k127_9649373_1 PFAM metal-dependent phosphohydrolase, HD sub domain K01120 - 3.1.4.17 0.0000000000000009716 85.0
HKD2_k127_9650033_0 FAD linked oxidase domain protein K00102 - 1.1.2.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001816 535.0
HKD2_k127_9650033_1 DUF1338 - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000211 347.0
HKD2_k127_965010_0 transcriptional regulator - - - 0.0000000000000000000000000000000000000000000000000004095 194.0
HKD2_k127_965010_1 Spermine spermidine synthase K00797 - 2.5.1.16 0.0000000000000000000000000000000000000000915 163.0
HKD2_k127_965010_2 Transcriptional regulator - - - 0.000000000000000000327 88.0
HKD2_k127_9651449_0 Belongs to the MurCDEF family K01924 - 6.3.2.8 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001273 540.0
HKD2_k127_9653925_0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane K07277 - - 0.000000000009796 78.0
HKD2_k127_966212_0 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity K03429 - 2.4.1.315 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000376 336.0
HKD2_k127_966212_1 - - - - 0.00000000000000000000002047 103.0
HKD2_k127_9663109_0 Metallopeptidase family M24 - - - 0.0000000000000000004039 101.0
HKD2_k127_9663109_1 polysaccharide deacetylase K00365,K01452,K16842,K22278 GO:0000003,GO:0000272,GO:0003006,GO:0005575,GO:0005618,GO:0005619,GO:0005623,GO:0005631,GO:0005975,GO:0005976,GO:0006022,GO:0006026,GO:0006030,GO:0006032,GO:0006037,GO:0006039,GO:0006040,GO:0006807,GO:0007049,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009272,GO:0009277,GO:0009653,GO:0009987,GO:0010383,GO:0010927,GO:0016043,GO:0016052,GO:0016998,GO:0017144,GO:0019953,GO:0022402,GO:0022411,GO:0022413,GO:0022414,GO:0022607,GO:0030154,GO:0030312,GO:0030435,GO:0030437,GO:0030476,GO:0031160,GO:0031505,GO:0032502,GO:0032505,GO:0032989,GO:0034218,GO:0034232,GO:0034293,GO:0042244,GO:0042546,GO:0042737,GO:0043170,GO:0043934,GO:0043935,GO:0044036,GO:0044085,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044277,GO:0044426,GO:0044462,GO:0044464,GO:0044703,GO:0045229,GO:0046348,GO:0048468,GO:0048646,GO:0048856,GO:0048869,GO:0051321,GO:0051704,GO:0070590,GO:0070591,GO:0070726,GO:0070910,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071852,GO:0071853,GO:0071854,GO:0071940,GO:0071944,GO:0071966,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575,GO:1903046 1.7.3.3,3.5.1.104,3.5.1.41,3.5.2.5 0.00000001023 66.0
HKD2_k127_9663109_2 Cytidylate kinase-like family - - - 0.00001097 57.0
HKD2_k127_9667924_0 Belongs to the pyruvate kinase family K00873 - 2.7.1.40 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002908 449.0
HKD2_k127_9667924_1 RelE-like toxin of type II toxin-antitoxin system HigB K07334 - - 0.0000000000000000000000000000004349 124.0
HKD2_k127_9667924_2 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides K03642 - - 0.000000000000000000000001211 120.0
HKD2_k127_9667924_3 TIGRFAM Addiction module antidote protein, HigA K21498 - - 0.00000000000000000001428 95.0
HKD2_k127_9679945_0 Ankyrin repeats (many copies) - - - 0.00000000004941 71.0
HKD2_k127_9684348_0 cytochrome c peroxidase K00428 - 1.11.1.5 0.00000000000000000000000000000000000000000000000000000009506 201.0
HKD2_k127_9684348_1 Putative zinc-finger - - - 0.000000000000000000000000000000000000004058 162.0
HKD2_k127_9684348_2 RNA polymerase sigma factor K03088 - - 0.00000000000000000000000000000001415 133.0
HKD2_k127_9689253_0 efflux transmembrane transporter activity K02004 - - 0.000000000000000000000000000000000000000000000000000000000000000000000000002076 270.0
HKD2_k127_9689253_1 ABC transporter K02003 - - 0.00000000000000000002005 91.0
HKD2_k127_9689253_2 MacB-like periplasmic core domain - - - 0.000000000000000006258 87.0
HKD2_k127_9690040_0 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth K00088 - 1.1.1.205 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001382 497.0
HKD2_k127_9690040_1 Cytochrome bd terminal oxidase subunit I K00425 - 1.10.3.14 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001161 340.0
HKD2_k127_9690040_2 radical SAM domain protein - - - 0.00000000000000000000000000000000001507 157.0
HKD2_k127_9707628_0 HELICc2 K03722 - 3.6.4.12 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002524 332.0
HKD2_k127_9707628_1 UPF0678 fatty acid-binding protein-like protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - 0.0000000000000000000004705 105.0
HKD2_k127_9707628_3 COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - 0.00000000000002762 75.0
HKD2_k127_9708135_0 Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction K00962 - 2.7.7.8 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000009399 447.0
HKD2_k127_9708135_1 PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000000000003544 274.0
HKD2_k127_9708135_2 Mycothiol maleylpyruvate isomerase N-terminal domain - - - 0.000000000000000000000000000000000000000000000000000000000000000001446 231.0
HKD2_k127_9708135_3 Cupredoxin-like domain - - - 0.0001744 49.0
HKD2_k127_9728943_0 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology K07025 - - 0.000000000000000000000000000000000000004749 154.0
HKD2_k127_9728943_1 Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - 0.00000000000000859 89.0
HKD2_k127_9728943_2 Tfp pilus assembly protein FimV - - - 0.00000000003386 68.0
HKD2_k127_9790045_0 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) K00937 - 2.7.4.1 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005889 587.0
HKD2_k127_9802870_0 LamB/YcsF family K07160 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006988 311.0
HKD2_k127_9802870_1 Protein of unknown function (DUF969) - - - 0.000000000000000000000000000000000000000000000000000000000000000000000000003178 271.0
HKD2_k127_9802870_2 Allophanate hydrolase subunit 2 K01457 - 3.5.1.54 0.000000000000001057 79.0
HKD2_k127_9802870_3 Membrane - - - 0.000000923 61.0
HKD2_k127_9803837_0 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family K03585 - - 0.0000000000000000000000000000000000000000000000000000000003706 209.0
HKD2_k127_9803837_1 Belongs to the low molecular weight phosphotyrosine protein phosphatase family - - - 0.00000000000223 76.0
HKD2_k127_9803837_2 MarR family - - - 0.00003552 53.0
HKD2_k127_98055_0 Catalyzes the biosynthesis of agmatine from arginine K01585 - 4.1.1.19 7.738e-238 752.0
HKD2_k127_98055_1 tRNA thio-modification K03151 GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004271 342.0
HKD2_k127_98055_2 PFAM NUDIX domain - - - 0.000000000000000000000000000000000000000000000001887 185.0
HKD2_k127_98055_3 PFAM thioesterase superfamily protein K07107 - - 0.00000000000000000000002277 112.0
HKD2_k127_9806565_0 polysaccharide deacetylase - - - 0.000000000000000000000000000000000000000000000001581 196.0
HKD2_k127_9806565_1 phosphinothricin N-acetyltransferase activity - - - 0.000000000000000000000000000000907 137.0
HKD2_k127_9806565_2 Glycosyl transferases group 1 - - - 0.00000000000000001727 95.0
HKD2_k127_9807055_0 oligopeptide transport K03305 - - 0.00000000000000000000000000000000000000000000000000007341 211.0
HKD2_k127_9807055_1 Type I phosphodiesterase / nucleotide pyrophosphatase - - - 0.0000000000000000000001224 114.0
HKD2_k127_9808390_0 3-beta hydroxysteroid dehydrogenase isomerase - - - 0.000000000000000000000000000000000000000000003211 175.0
HKD2_k127_9808390_1 Serine/threonine phosphatases, family 2C, catalytic domain K20074 - 3.1.3.16 0.00000000000000000000000000000000000000001668 165.0
HKD2_k127_9808390_2 phosphatidate phosphatase activity K00901,K01096,K19302 - 2.7.1.107,3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27 0.0000000000000000000000000000007322 139.0
HKD2_k127_9808390_3 Thioesterase superfamily K10806 - - 0.0000000000000000000000000002194 119.0
HKD2_k127_9808390_5 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA K01972 GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 0.0000000000003674 77.0
HKD2_k127_9813980_0 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate K03701 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003421 399.0
HKD2_k127_9813980_1 helix_turn_helix multiple antibiotic resistance protein - - - 0.00000000000000000000000000000000000000002818 162.0
HKD2_k127_9813980_2 dUTP diphosphatase activity K01520,K13038 GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23,4.1.1.36,6.3.2.5 0.0000000000000000000000000000000006016 134.0
HKD2_k127_9813980_3 Response regulator receiver domain K03413 - - 0.00000000000000000001636 101.0
HKD2_k127_9814747_0 membrane protein involved in D-alanine K19294 - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001094 414.0
HKD2_k127_9833581_0 Protein of unknown function (DUF3417) K00688 - 2.4.1.1 0.00000000000000000000000000000000000000000000000000000000000000000000000002466 260.0
HKD2_k127_9833581_1 TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 K01838 - 5.4.2.6 0.00000000000000000000000000000000000000000000000000000001526 218.0
HKD2_k127_9836469_0 serine threonine protein kinase K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006712 326.0
HKD2_k127_9841598_1 Belongs to the ATCase OTCase family - GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0019627,GO:0034641,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576 - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001937 317.0
HKD2_k127_9841598_2 Thioredoxin-like - - - 0.00000000000000000000000000000000000000000000000109 179.0
HKD2_k127_9841994_0 DEAD DEAH box K03724 - - 1.259e-196 629.0
HKD2_k127_986372_0 Belongs to the GarS family - - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000004192 533.0
HKD2_k127_986372_1 Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases K00974 - 2.7.7.72 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000001789 287.0
HKD2_k127_9869766_0 Phosphopantetheine attachment site - - - 1.174e-227 738.0
HKD2_k127_9869766_1 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA K01754 - 4.3.1.19 0.00000000000000000000000000000000000000000000000000000000000001144 228.0
HKD2_k127_9873122_0 Acyltransferase family - - - 0.000000000000000000000000000000000000000002122 167.0
HKD2_k127_9873122_1 Sulfatase - - - 0.00000000000000000000003394 108.0
HKD2_k127_9885236_0 Resolvase, RNase H domain protein fold K06959 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000008297 624.0
HKD2_k127_9909573_0 Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner K03596 - - 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000003608 488.0
HKD2_k127_9909573_1 Trypsin domain PDZ domain protein - - - 0.000000000000000000000000000000000000000000009801 169.0
HKD2_k127_9910164_0 Cytochrome c - - - 0.00000000000000000000000000000000000000000000000000000000000000000002849 250.0
HKD2_k127_9910164_1 B12 binding domain K14084 - - 0.000000000000000000000000000000000000000000003211 175.0
HKD2_k127_9910353_0 aminotransferase class I and II K00812 - 2.6.1.1 0.00000000000000000000000004976 124.0
HKD2_k127_9910353_1 Histidine kinase-like ATPase domain - - - 0.0000000007082 61.0
HKD2_k127_9941413_0 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP K00763 - 6.3.4.21 1.8e-199 632.0
HKD2_k127_9941413_1 Ribose-phosphate pyrophosphokinase K00948 - 2.7.6.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006704 340.0
HKD2_k127_9943197_0 Catalyzes the synthesis of activated sulfate K00958 - 2.7.7.4 7.736e-232 726.0
HKD2_k127_9943558_0 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family K18138 - - 1.825e-224 707.0
HKD2_k127_9943989_0 WD40 domain protein beta Propeller K08884,K12132 - 2.7.11.1 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000001648 475.0
HKD2_k127_9950546_0 xaa-Pro dipeptidase K06106,K14213 GO:0003674,GO:0003824,GO:0004177,GO:0004180,GO:0004181,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008239,GO:0009987,GO:0016787,GO:0019538,GO:0019752,GO:0031974,GO:0031981,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0070011,GO:0070013,GO:0071704,GO:0140096,GO:1901564 3.4.13.9 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000198 320.0
HKD2_k127_9952530_0 Belongs to the ompA family - - - 0.0000000000000000000000000000000000008841 147.0
HKD2_k127_9952530_1 PFAM von Willebrand factor type A - - - 0.0000000000000000000003855 106.0
HKD2_k127_9952530_2 DNA-templated transcription, initiation K03088 - - 0.00000000000000000009321 95.0
HKD2_k127_9969210_0 Protein involved in meta-pathway of phenol degradation - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000258 382.0
HKD2_k127_9969210_1 Bacterial periplasmic substrate-binding proteins K01713 - 4.2.1.51,4.2.1.91 0.000000000000000000000000009453 113.0
HKD2_k127_9969210_2 TIGRFAM diguanylate cyclase - - - 0.00004956 48.0
HKD2_k127_9984635_0 PFAM Glutamyl glutaminyl-tRNA synthetase, class Ic, catalytic K01886 - 6.1.1.18 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002854 411.0
HKD2_k127_9984635_1 Protein of unknown function (DUF423) - - - 0.0000000000000000000000000000003912 129.0
HKD2_k127_9984635_2 Protein tyrosine kinase K12132 - 2.7.11.1 0.00000000000000000000000001586 117.0
HKD2_k127_9989743_0 AAA domain - - - 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000001126 322.0
HKD2_k127_9989743_1 PFAM Anion-transporting ATPase K01551 - 3.6.3.16 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000002066 308.0
HKD2_k127_9989743_2 Anion-transporting ATPase K01551 - 3.6.3.16 0.00000000000000000000000000000000000000000000000003964 191.0
HKD2_k127_9989743_3 PBS lyase HEAT domain protein repeat-containing protein - - - 0.0000000002508 64.0
HKD2_k127_9996979_0 DEAD-like helicases superfamily K05592 - 3.6.4.13 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000002851 557.0
HKD2_k127_9996979_1 Sir2 family - - - 0.0000000000000000000000000000000000000000000000000000000002773 208.0
HKD2_k127_9998045_0 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00331 - 1.6.5.3 0.00000000000000000000000000000000000000000000002336 175.0
HKD2_k127_9998045_1 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient K00330 - 1.6.5.3 0.00000000000000000000000000000000001952 139.0